Page last updated: 2024-09-04

sk&f 100330-a and gamma-aminobutyric acid

sk&f 100330-a has been researched along with gamma-aminobutyric acid in 15 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(sk&f 100330-a)
Trials
(sk&f 100330-a)
Recent Studies (post-2010)
(sk&f 100330-a)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
200040,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomysk&f 100330-a (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19909 (60.00)18.7374
1990's5 (33.33)18.2507
2000's1 (6.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ali, FE; Bondinell, WE; Dandridge, PA; Frazee, JS; Garvey, E; Girard, GR; Kaiser, C; Ku, TW; Lafferty, JJ; Moonsammy, GI1
Agmo, A; Gutiérrez, M; Guzmán, M; Pruneda, R1
Enna, SJ; Ferkany, JW; Karbon, EW1
Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD1
Falch, E; Krogsgaard-Larsen, P1
Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A1
Bonanno, G; Raiteri, M2
Bennett, JP; Cruz, CJ; Ferrari, MB1
Löscher, W1
Löscher, W; Schwark, WS1
Enna, SJ; Zorn, SH1
Agmo, A; Soria, P1
Golovanevsky, V; Kanner, BI1
Bonanno, G; Raiteri, L; Raiteri, M; Stigliani, S; Zedda, L1

Other Studies

15 other study(ies) available for sk&f 100330-a and gamma-aminobutyric acid

ArticleYear
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:5

    Topics: 4-Aminobutyrate Transaminase; Administration, Oral; Alkylation; Amino Acids; Animals; Brain; Carboxylic Acids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes

1985
GABAergic drugs and conflict behavior in the rat: lack of similarities with the actions of benzodiazepines.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:3

    Topics: Alkynes; Aminocaproates; Animals; Baclofen; Behavior, Animal; Benzodiazepines; Bicuculline; Brain; Conflict, Psychological; Drug Interactions; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1991
Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice.
    Neuropharmacology, 1991, Volume: 30, Issue:11

    Topics: Animals; Anticonvulsants; Catalepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Receptors, Dopamine; Receptors, GABA-A; Time Factors

1991
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
    European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3

    Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tiagabine

1991
GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
    Drug design and delivery, 1989, Volume: 4, Issue:3

    Topics: Anticonvulsants; gamma-Aminobutyric Acid; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Structure-Activity Relationship; Synaptosomes

1989
Kinetic characterization of inhibition of gamma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine.
    Journal of neurochemistry, 1988, Volume: 50, Issue:3

    Topics: Animals; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Chemical Phenomena; Chemistry; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Neurons; Nicotinic Acids; Nipecotic Acids; Proline

1988
Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain.
    British journal of pharmacology, 1987, Volume: 91, Issue:1

    Topics: Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Dopamine; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nerve Endings; Nicotinic Acids; Nipecotic Acids; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes

1987
Presence of a gamma-aminobutyric acid (GABA) uptake system on cholinergic terminals of rat hippocampus: evidence for neuronal coexistence of acetylcholine and GABA?
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1

    Topics: Acetylcholine; Animals; Choline; Cholinergic Fibers; gamma-Aminobutyric Acid; Hemicholinium 3; Hippocampus; Male; Neurons; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains

1987
GABA-mimetic drugs enhance apomorphine-induced contralateral turning in rats with unilateral nigrostriatal dopamine denervation: implications for the therapy of Parkinson's disease.
    Annals of neurology, 1987, Volume: 21, Issue:1

    Topics: Alkynes; Aminocaproates; Animals; Antiparkinson Agents; Apomorphine; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Nicotinic Acids; Parkinson Disease; Rats; Rats, Inbred Strains

1987
Anticonvulsant action in the epileptic gerbil of novel inhibitors of GABA uptake.
    European journal of pharmacology, 1985, Mar-26, Volume: 110, Issue:1

    Topics: Animals; Anticonvulsants; Depression, Chemical; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Male; Nicotinic Acids; Nipecotic Acids

1985
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1985, Volume: 329, Issue:4

    Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains; Seizures

1985
GABA uptake inhibitors produce a greater antinociceptive response in the mouse tail-immersion assay than other types of GABAergic drugs.
    Life sciences, 1985, Nov-18, Volume: 37, Issue:20

    Topics: Analgesics; Animals; Biological Transport; Brain; Corpus Striatum; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Nicotinic Acids; Nipecotic Acids; Oxotremorine; Pain; Tail

1985
GABAergic drugs and sexual motivation, receptivity and exploratory behaviors in the female rat.
    Psychopharmacology, 1997, Volume: 129, Issue:4

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Exploratory Behavior; Female; gamma-Aminobutyric Acid; Male; Nicotinic Acids; Rats; Rats, Wistar; Sexual Behavior, Animal

1997
The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive. Identification of a major target residue.
    The Journal of biological chemistry, 1999, Aug-13, Volume: 274, Issue:33

    Topics: Carrier Proteins; Ethyl Methanesulfonate; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; HeLa Cells; Humans; Membrane Proteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nicotinic Acids; Organic Anion Transporters; Protein Structure, Secondary; Sulfhydryl Reagents

1999
Multiple mechanisms of transmitter release evoked by "pathologically" elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calcium.
    Journal of neurochemistry, 2002, Volume: 80, Issue:4

    Topics: Animals; Anticonvulsants; Brain Chemistry; Calcium; Carrier Proteins; Cerebral Cortex; Chelating Agents; Clonazepam; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Extracellular Space; Fluorescent Dyes; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Membrane Proteins; Membrane Transport Proteins; Nicotinic Acids; Organic Anion Transporters; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Synaptosomes; Thiazepines; Tritium

2002