sivelestat has been researched along with interleukin-8 in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsukawa, A; Matsuura, K; Okamura, H; Tanaka, N; Ujioka, T; Yoshinaga, M | 1 |
| Fujimura, M; Matsuda, T; Matsushima, K; Myou, S; Tachibana, H; Tsujiura, M; Xiu, Q | 1 |
| Ooshima, H; Usui, A; Watanabe, T; Yamazaki, T; Yasuura, K | 1 |
| Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ | 1 |
| Muraguchi, M; Murata, K; Nishisho, T; Ohmoto, Y; Ohsaki, H; Shiba, K; Takeda, E; Taketani, Y; Tonai, T | 1 |
| Hiramatsu, Y; Homma, S; Matsuzaki, K; Sakakibara, Y; Sato, S; Shigeta, O | 1 |
| Hinohara, H; Kadoi, Y; Kunimoto, F; Kuwano, H; Ogata, K; Yamaki, E | 1 |
| Fujino, Y; Hata, H; Iwai, S; Matsuda, H; Matsumiya, G; Nishimura, M; Ono, M; Ryugo, M; Sawa, Y; Takano, H; Yamauchi, T | 1 |
| Mikawa, K; Misumi, T; Morikawa, O; Nishina, K; Obara, H; Tanaka, T | 1 |
| Fukuda, I; Kondo, N; Suzuki, Y; Wakayama, F | 1 |
| Kondo, T; Niikawa, H; Oishi, H; Sugawara, T; Suzuki, S; Tabata, T | 1 |
| Aoki, H; Endo, S; Inoue, Y; Kojika, M; Nakadate, T; Sato, N; Suzuki, Y; Yaegashi, Y; Yamada, Y; Yoshida, Y | 1 |
| Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H | 1 |
| Bessho, R; Fujii, M; Miyagi, Y; Nitta, T; Ochi, M; Shimizu, K | 1 |
| Endo, S; Inada, K; Shibata, S; Shioya, N; Takahashi, G | 1 |
| Inada, E; Iwanuma, Y; Kajiyama, Y; Kugimiya, T; Kumakura, S; Nagaoka, I; Sugasawa, Y; Takeuchi, K; Tsurumaru, M; Yamaguchi, K | 1 |
| Masaoka, N; Nakajima, Y | 1 |
| Cai, JH; Chai, JK; Chi, YF; Deng, HP; Feng, R; Hu, QG; Liu, W; Ma, L; Shen, CA; Yin, HN; Zhang, XB; Zou, XF | 1 |
| Eguchi, T; Hamanaka, K; Hasegawa, J; Koizumi, T; Komatsu, Y; Kondo, R; Kubo, K; Shiina, T; Yamamoto, H; Yoshida, K | 1 |
| Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H | 1 |
| Huang, P; Li, QG; Xiao, XG; Zu, HG | 1 |
6 trial(s) available for sivelestat and interleukin-8
| Article | Year |
|---|---|
[Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].
Topics: Cytokines; Esophageal Neoplasms; Esophagectomy; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Lung Diseases; Postoperative Complications; Postoperative Period; Respiration, Artificial; Serpins; Sulfonamides; Time Factors | 2005 |
Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
Topics: Acute Disease; Aged; Cardiopulmonary Bypass; Female; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Perfusion; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2006 |
Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction.
Topics: Acute Disease; Adolescent; Adult; Aged; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Leukocytes; Middle Aged; Oxygen; Pulmonary Circulation; Pulmonary Surfactant-Associated Protein D; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Systemic Inflammatory Response Syndrome; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
Topics: Acute Lung Injury; Aged; Anti-Inflammatory Agents; Aortic Valve; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cardiopulmonary Bypass; Female; Glycine; Heart Valve Prosthesis Implantation; Humans; Inflammation Mediators; Infusions, Intravenous; Interleukin-6; Interleukin-8; Leukocyte Elastase; Lung; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Pulmonary Gas Exchange; Sulfonamides; Time Factors; Treatment Outcome | 2010 |
Effects of sivelestat on bronchial inflammatory responses after esophagectomy.
Topics: Acute Lung Injury; Aged; Bronchitis; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Postoperative Complications; Premedication; Respiratory Distress Syndrome; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2011 |
Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung re-expansion following one-lung ventilation during thoracic surgery.
Topics: Actin Cytoskeleton; Actins; Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Interleukin-8; Lung; Male; Malondialdehyde; Middle Aged; Neutrophils; One-Lung Ventilation; Oxygen; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgical Procedures | 2013 |
15 other study(ies) available for sivelestat and interleukin-8
| Article | Year |
|---|---|
Interleukin-8 as an essential factor in the human chorionic gonadotropin-induced rabbit ovulatory process: interleukin-8 induces neutrophil accumulation and activation in ovulation.
Topics: Animals; Chorionic Gonadotropin; Female; Glycine; Humans; Interleukin-8; Neutrophil Activation; Neutrophils; Ovary; Ovulation; Peroxidase; Rabbits; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Role of leukotriene B4 in bronchial hyperresponsiveness induced by interleukin-8.
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Glycine; Guinea Pigs; Immunosuppressive Agents; Interleukin-8; Leukocyte Elastase; Leukotriene B4; Male; Neutrophils; Phenylpropionates; Sulfonamides | 1998 |
Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury.
Topics: Animals; Cardiopulmonary Bypass; Dogs; Extravascular Lung Water; Glycine; Hemodynamics; Interleukin-6; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Lung; Oxygen; Protective Agents; Pulmonary Circulation; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance | 1999 |
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 2000 |
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
Topics: Animals; Blood-Brain Barrier; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Gene Expression; Glycine; Growth Substances; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interleukin-8; Leukocyte Elastase; Motor Activity; Peroxidase; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Serine Proteinase Inhibitors; Spinal Cord; Spinal Cord Injuries; Sulfonamides | 2001 |
Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation.
Topics: Actins; CD11b Antigen; Cell Adhesion Molecules; Chemotactic Factors; Chemotaxis, Leukocyte; Extracorporeal Circulation; Glycine; Humans; Inflammation Mediators; Interleukin-8; L-Selectin; Leukocyte Elastase; Models, Cardiovascular; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides | 2005 |
Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.
Topics: Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Endotoxins; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Glycine; Humans; In Vitro Techniques; Interleukin-8; Polymerase Chain Reaction; Pulmonary Alveoli; Respiratory Mucosa; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Topics: Animals; Cardiopulmonary Bypass; Glycine; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Neutrophils; Peroxidase; Rabbits; Respiratory Distress Syndrome; Sulfonamides | 2007 |
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
Topics: Animals; Cytokines; Endotoxins; Escherichia coli; Glycine; Injections, Intraperitoneal; Interleukin-8; Leukocyte Elastase; Lung; Lung Transplantation; Male; Neutrophils; Pneumonia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Tissue and Organ Harvesting; Tumor Necrosis Factor-alpha | 2007 |
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis | 2010 |
Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture.
Topics: Acute Lung Injury; Flow Cytometry; Glycine; Granulocytes; Humans; In Vitro Techniques; Interleukin-8; Lipopolysaccharides; Monocytes; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Tumor Necrosis Factor-alpha | 2010 |
Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.
Topics: Adult; Amniotic Fluid; Female; Fetal Membranes, Premature Rupture; Glycine; Humans; Injections, Intravenous; Interleukin-6; Interleukin-8; Magnesium Sulfate; Obstetric Labor, Premature; Pregnancy; Ritodrine; Serine Proteinase Inhibitors; Sulfonamides; Tocolytic Agents; Young Adult | 2012 |
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Topics: Animals; Blast Injuries; Bronchoalveolar Lavage Fluid; Burns; Carbon Dioxide; Disease Models, Animal; Glycine; Interleukin-8; Leukocyte Elastase; Lung Injury; Male; Oxygen; Partial Pressure; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2013 |
[Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury].
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Capillary Permeability; Dogs; Extravascular Lung Water; Glycine; Infusions, Intravenous; Interleukin-8; Male; Pulmonary Edema; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2014 |
Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-8; Leukocyte Elastase; Lung; Rats; Rats, Sprague-Dawley; Sulfonamides; Systemic Inflammatory Response Syndrome | 2016 |