sivelestat has been researched along with glycine in 310 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 67 (21.61) | 18.2507 |
2000's | 112 (36.13) | 29.6817 |
2010's | 115 (37.10) | 24.3611 |
2020's | 16 (5.16) | 2.80 |
Authors | Studies |
---|---|
Hecker, M; Kaw, S; Southan, GJ; Vane, JR; Warner, TD | 1 |
Imaki, K; Kawabata, K; Miyamoto, T; Sugitani, M; Suzuki, M; Toda, M | 1 |
Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
Aoshiba, K; Kakuta, Y; Konno, K; Nagai, A; Ozawa, Y; Yasui, S | 1 |
Fujimoto, K; Kobayashi, T; Kubo, K; Matsuzawa, Y; Okada, K; Shinozaki, S; Sugane, K | 1 |
Isohama, Y; Kai, H; Miyata, T; Takahama, K; Yoshitake, K | 1 |
Guo, L; Ikei, S; Ogawa, M; Sugita, H; Yamaguchi, Y | 1 |
Kakimoto, K; Matsukawa, A; Nakamura, H; Yoshinaga, M | 1 |
Hayano, T; Honda, T; Kobayashi, T; Koizumi, T; Kubo, K; Sakai, A; Sekiguchi, M | 1 |
Aishita, H; Nakagawa, T; Sawada, M; Shintani, T; Takamoto, M | 1 |
Homma, T; Kobayashi, T; Koyama, S; Nakagawa, S; Yoshimura, K | 1 |
Maeda, T; Matsukawa, A; Ohkawara, S; Takagi, K; Yoshinaga, M | 1 |
Iwamura, H; Moore, AR; Willoughby, DA | 1 |
Hasegawa, N; Ishizaka, A; Kanazawa, M; Nakagawa, N; Nakamura, H; Obata, T; Sakamaki, F; Sato, K; Sayama, K; Tasaka, S; Terashima, T; Urano, T; Waki, Y | 1 |
Johno, M; Murakami, K; Nakagaki, T; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
Akizuki, E; Goto, M; Ichiguchi, O; Miyanari, N; Mori, K; Ogawa, M; Wang, FS; Yamada, S; Yamaguchi, Y | 1 |
Ichikawa, H; Iino, Y; Kamoshita, N; Kobayashi, J; Morishita, Y; Ohwada, S; Ohya, T; Takahashi, T; Tomizawa, N | 1 |
Ichikawa, H; Iino, Y; Izumi, M; Kamoshita, N; Kobayashi, J; Morishita, Y; Nakamura, S; Ogawa, T; Ohwada, S; Ohya, T; Takahashi, T; Tomizawa, N | 1 |
Binder, BR; Kushimoto, S; Okabe, H; Okajima, K | 1 |
Harada, N; Kushimoto, S; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
Amino, T; Imaki, K; Kawamura, M; Kobayashi, K; Mohri, T; Nagao, Y; Nakai, H; Nakayama, Y; Okada, T; Sakai, Y | 1 |
Akizuki, E; Goto, M; Ichiguchi, O; Matsumura, F; Miyanari, N; Mori, K; Ogawa, M; Yamada, S; Yamaguchi, Y | 1 |
Harada, N; Johno, M; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
Furuno, T; Hara, N; Hidaka, K; Mitsuyama, T; Tanaka, T | 1 |
Harada, N; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Tanaka, K; Uchiba, M | 1 |
Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M; Takao, Y | 1 |
Higashi, Y; Kato, A; Murakami, T; Sato, M; Watanabe, F; Yata, N | 1 |
Kitamura, S | 2 |
Kitamura, S; Kobayashi, J | 1 |
Hiyama, K; Ishioka, S; Maeda, A; Taooka, Y; Yamakido, M | 1 |
Kondo, M; Nagai, A; Takeda, Y; Tamaoki, J; Yamawaki, I | 1 |
Hattori, S; Kaneko, K; Kudoh, I; Ohara, M; Okumura, F; Wiener-Kronish, J; Yamada, H | 1 |
Harada, N; Liu, W; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
Inada, M; Ogawa, M; Yamashita, J | 1 |
Ishioka, S | 1 |
Ishihara, H; Kudoh, A; Kudoh, E; Matsuki, A | 1 |
An, XY; Kamohara, H; Mita, S; Ogawa, M; Sakamoto, K | 1 |
Matsumura, F; Ogawa, M; Yamaguchi, Y | 1 |
Inoue, T; Kyi, M; Miyake, S; Miyazaki, Y; Sawada, M; Yoshizawa, Y | 1 |
Isohama, Y; Kai, H; Kido, T; Miyata, T; Tai, S; Takahama, K | 1 |
Matsukawa, A; Matsuura, K; Okamura, H; Tanaka, N; Ujioka, T; Yoshinaga, M | 1 |
Haga, Y; Ogawa, M | 1 |
Fujimura, M; Matsuda, T; Matsushima, K; Myou, S; Tachibana, H; Tsujiura, M; Xiu, Q | 1 |
Arakawa, M; Gejyo, F; Imai, N; Kazama, JJ; Kimura, H; Kuroda, T; Suzuki, S | 1 |
Higashi, Y; Higashikawa, F; Murakami, T; Okochi, A; Sato, M; Takano, M; Yata, N | 1 |
Akizuki, E; Horiuchi, T; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Wang, FS; Yamada, S; Yamaguchi, Y | 1 |
Abe, T; Handa, M; Ohya, N; Sakuma, T; Takahashi, K; Usuda, K | 1 |
Fujita, T; Mori, H; Nishiyama, K; Shichino, Y; Shimizu, K; Shinomiya, K; Suzuki, Y; Ueda, H; Yamaguchi, K; Yanagi, H; Yonezawa, H | 1 |
Fujita, T; Mori, H; Nishibata, K; Nishiyama, K; Oida, H; Shichino, Y; Shimizu, K; Shinomiya, K; Suzuki, Y; Tanaka, M; Ueda, H; Yamaguchi, K; Yanagi, H; Yonezawa, H | 1 |
Fujita, T; Mori, H; Nishibata, K; Nishiyama, K; Oida, H; Shichino, Y; Shimizu, K; Suzuki, Y; Tanaka, M; Yamaguchi, K; Yanagi, H; Yonezawa, H | 1 |
Aze, Y; Fujita, T; Mori, H; Nanba, T; Nishibata, K; Nishiyama, K; Oida, H; Oku, H; Shichino, Y; Shimizu, K; Shinomiya, K; Suzuki, Y; Tanaka, M; Ueda, H; Yamaguchi, K; Yanagizawa, Y; Yonezawa, H | 1 |
Fujita, T; Ide, M; Ishii, T; Katsumata, T; Numata, H; Okamoto, M; Suzuki, H; Tamura, K | 1 |
Aze, Y; Chihara, N; Fujita, T; Kitagawa, T; Nakagawa, Y; Nishimura, T; Ozeki, Y; Sakamoto, T; Shinomiya, K; Shirakawa, R; Sugai, S | 1 |
Aze, Y; Chihara, N; Fujita, T; Ikeda, Y; Nakagawa, Y; Nishimura, T; Ozeki, Y; Sakamoto, T; Shinomiya, K; Shirakawa, R; Sugai, S | 1 |
Chihara, N; Fujita, T; Ikeda, Y; Itagaki, I; Nakagawa, Y; Nishimura, T; Ozeki, Y; Sakai, M; Sakamoto, T; Shinomiya, K; Shirakawa, R; Sugai, S | 1 |
Harada, N; Irie, T; Isobe, H; Liu, W; Murakami, K; Okajima, K | 1 |
Kawashima, Y; Morishita, Y; Ohwada, S; Ohya, T; Takeyoshi, I; Tomizawa, N | 1 |
Imamura, M; Mikami, Y; Takahashi, H; Yamauchi, H | 1 |
Aoshiba, K; Kondo, M; Nagai, A; Nakata, J; Tagaya, E; Tamaoki, J; Yamawaki, I | 1 |
Adachi, M; Kawashima, Y; Morishita, Y; Ogawa, T; Ohwada, S; Ohya, T; Takeyoshi, I; Tomizawa, N | 1 |
Nishizaki, T; Soejima, Y; Sugimachi, K; Uchiyama, H; Yanaga, K; Yoshizumi, T | 1 |
Chen, HM; Chen, JC; Chen, MF; Chi, CP; Chi, TY; Fan, LL; Hwang, TL; Shyr, MH | 1 |
Ishihara, K; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Yamaguchi, Y | 1 |
Aizawa, H; Hara, N; Inoue, H; Koto, H; Matsumoto, K; Nakano, H | 1 |
Ooshima, H; Usui, A; Watanabe, T; Yamazaki, T; Yasuura, K | 1 |
Ikeda, Y; Kamanaka, Y; Kondo, K; Shimakura, A; Suzuki, Y; Umemura, K | 1 |
Euzger, HS; Flower, RJ; Goulding, NJ; Perretti, M | 1 |
Aizawa, H; Hara, N; Hirose, T; Koto, H; Matsumoto, K; Miyazaki, H; Nakano, H; Nishima, S; Nogami, H | 1 |
Aze, Y; Hagio, T; Kawabata, K; Matsumoto, S; Nakao, S; Ohno, H; Orita, S | 1 |
Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ | 1 |
Fujimoto, J; Fukushima, J; Kudoh, I; Miyazaki, H; Ohara, M; Okumura, F; Tazawa, T; Yamada, H | 1 |
Hanaoka, M; Kaneki, T; Koizumi, T; Kubo, K; Yamamoto, H | 1 |
Kawamura, Y; Nakatani, K; Sekine, I; Takeshita, S; Tsujimoto, H | 1 |
Fukumoto, Y; Moriyama, Y; Nakamura, K; Sakasegawa, K; Sakata, R; Toda, R; Ueno, M; Yamamoto, H; Yotsumoto, G | 1 |
Hagio, T; Kawabata, K; Matsumoto, S; Matsuoka, H; Nakao, S; Ohno, H | 1 |
Muraguchi, M; Murata, K; Nishisho, T; Ohmoto, Y; Ohsaki, H; Shiba, K; Takeda, E; Taketani, Y; Tonai, T | 1 |
Ishibashi, M; Ishii, H; Kuraki, T; Nishida, T; Takayama, M; Yoshida, M | 1 |
Ichikawa, H; Naito, Y; Nakamura, Y; Ochiai, J; Sugimoto, N; Yoshida, N; Yoshikawa, T | 1 |
Kawabata, K; Matsuoka, S; Repine, JE; Zeiher, BG | 1 |
Fujita, S; Hamanaka, N; Matsuoka, S; Nakai, H; Nakayama, Y; Odagaki, Y; Toda, M | 1 |
Ishii, K; Ito, Y; Kakita, A; Katagiri, H; Majima, M; Matsumoto, Y | 1 |
Doi, K; Horiuchi, T; Kimura, N; Tabo, T; Tanaka, K; Uchinami, M; Yokomachi, J; Yoshida, M | 1 |
Hayashi, N; Kato, S; Kondo, K; Ogawa, M; Tanaka, E; Yamashita, J | 1 |
Ishikawa, N; Kawaguchi, M; Oda, M; Tsunezuka, Y; Watanabe, G | 1 |
Hagio, T; Kawabata, K; Matsuoka, S | 1 |
Miyate, Y; Sato, K; Segawa, Y; Soma, J; Suzuki, M | 1 |
Hiwasa, T; Ikeda, K; Iwamoto, I; Nakajima, H; Saito, Y; Suzuki, K; Tamachi, T | 1 |
Abiru, T; Hagio, T; Kawabata, K; Matsumoto, S; Nakao, S; Ohno, H | 1 |
Bellomo, R; Naka, T; Uchino, S; Wan, L | 1 |
Harada, N; Mori, M; Okajima, K; Uchiba, M | 1 |
Artigas, A; Bernard, G; Dmitrienko, A; Jackson, K; Thompson, BT; Vincent, JL; Zeiher, BG | 1 |
Goto, F; Hinohara, H; Ieta, K; Kadoi, Y; Kosaka, T; Kunimoto, F; Saito, S | 1 |
Abiru, T; Aikawa, N; Hamada, C; Hirasawa, H; Ishizaka, A; Kubota, T; Matsuoka, S; Ogawa, M; Taenaka, N; Tamakuma, S | 1 |
Sugahara, K; Takara, I; Tokumine, J; Tomiyama, H | 1 |
Arinobu, Y; Himeji, D; Kikuchi, I; Kojima, T; Oguma, A; Ueda, A | 1 |
Kotake, Y; Matsumoto, M; Morisaki, H; Takeda, J; Yamamoto, M | 1 |
Abiru, T; Aikawa, N; Fujishima, S; Kobayashi, M; Matsuoka, S | 1 |
Hagio, T; Kawabata, K; Matsumoto, S; Matsuoka, S; Nakao, S | 1 |
Hiramatsu, Y; Homma, S; Matsuzaki, K; Sakakibara, Y; Sato, S; Shigeta, O | 1 |
Abe, M; Imai, K; Inagaki, N; Ishikawa, M; Kadoyama, T; Kurokawa, J; Nakagawa, T; Soga, Y; Suzuki, T; Takeda, M | 1 |
Akimau, P; Inoue, Y; Nishino, M; Seiyama, A; Shimazu, T; Sugimoto, H; Tanaka, H; Ukai, I | 1 |
Hinohara, H; Kadoi, Y; Kunimoto, F; Kuwano, H; Ogata, K; Yamaki, E | 1 |
Andoh, K; Hoshi, K; Kaise, A; Kato, M; Kurosawa, S; Satoh, D | 1 |
Endo, K; Hayashi, K; Kimura, Y; Mitsui, M; Shimoyama, M; Takano, K; Tsukahara, A | 1 |
Fujimoto, K; Jian, MY; Koizumi, T; Kubo, K; Tsushima, K | 1 |
Imabayashi, T; Kakihana, Y; Kanmura, Y; Matsunaga, A; Okayama, N; Omae, T; Setoguchi, D | 1 |
Takayama, N; Uchida, K | 1 |
Chida, K; Enomoto, N; Imokawa, S; Nagayama, M; Sano, T; Suda, T; Todate, A; Uchiyama, H; Yasuda, K | 1 |
Abe, K; Hiroshi, T; Matsuda, H; Matsumiya, G; Sakurai, M; Sawa, Y; Yamauchi, T | 1 |
Arroliga, AC; Diaz Guzman Zavala, E; Santacruz, JF | 1 |
Fujino, Y; Hata, H; Iwai, S; Matsuda, H; Matsumiya, G; Nishimura, M; Ono, M; Ryugo, M; Sawa, Y; Takano, H; Yamauchi, T | 1 |
Fujino, Y; Fujita, Y; Maeda, Y; Mashimo, T; Nishimura, M; Uchiyama, A | 1 |
Fujita, K; Hosotsubo, H; Inoue, Y; Ogura, H; Shimazu, T; Sugimoto, H; Tanaka, H; Ukai, I | 1 |
Chinen, H; Hibi, T; Hisamatsu, T; Inoue, N; Iwao, Y; Kamada, N; Matsuoka, K; Morohoshi, Y; Ogata, H; Okamoto, S; Sato, T; Takaishi, H | 1 |
Hashimoto, S; Shime, N | 1 |
Fukunaga, M; Iba, T; Kidokoro, A; Sugimotoa, K; Takuhiro, K; Yoshikawa, S | 1 |
Du, GH; Gao, F | 1 |
Mikawa, K; Misumi, T; Morikawa, O; Nishina, K; Obara, H; Tanaka, T | 1 |
Kito, K; Minami, T | 1 |
Hihara, J; Konishi, K; Mizuiri, H; Suzuki, T; Tanabe, K; Taomoto, J; Ukon, K; Wada, Y; Yoshida, K | 1 |
Akaike, H; Kawasaki, K; Miyauchi, A; Ouchi, K | 1 |
Amano, J; Fukui, D; Furusawa, T; Sakaguchi, M; Seto, T; Terasaki, T; Tsukioka, K; Wada, Y | 1 |
Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Takemoto, Y; Tanaka, T; Tsuchida, K; Yoshimura, R | 1 |
Furuhashi, T; Ishihara, K; Kihara, S; Mori, K; Ogawa, M; Uchino, S; Yamada, S; Yamaguchi, Y | 1 |
Dobashi, K; Hisada, T; Ishizuka, T; Mori, M; Shimizu, Y; Utsugi, M | 1 |
Katashima, S; Kikuchi, T; Kugimiya, T | 1 |
Ando, M; Ashihara, Y; Fukami, T; Hiroshige, S; Kumamoto, T; Miyazaki, E; Noguchi, T; Ohishi, K; Okubo, T; Sugisaki, K; Tsuda, T; Ueo, M; Yoshitake, S | 1 |
Hamai, Y; Hihara, J; Mizuiri, H; Oeda, M; Sanada, Y; Shigematsu, H; Suzuki, T; Tanabe, K; Tsutani, Y; Ukon, K; Wada, Y; Yoshida, K | 1 |
Nakajima, H; Nakajima, S; Sawaguchi, H | 1 |
Fukuda, I; Kondo, N; Suzuki, Y; Wakayama, F | 1 |
Jessen, ME | 1 |
Akagi, R; Inoue, K; Maeshima, K; Morimatsu, H; Morita, K; Omori, E; Shimizu, H; Takahashi, T; Takeuchi, M; Toda, Y | 1 |
Kaji, A; Rinka, H; Yoshida, T | 1 |
Kwon, AH; Qiu, Z | 1 |
Kondo, T; Niikawa, H; Oishi, H; Sugawara, T; Suzuki, S; Tabata, T | 1 |
Fukuda, Y; Hirakata, Y; Izumikawa, K; Kamhira, S; Kohno, S; Miyazaki, Y; Seki, M; Tsukamoto, K; Yamada, Y; Yanagihara, K | 1 |
Akamoto, S; Izuishi, K; Okano, K; Sano, T; Suzuki, Y; Usuki, H; Wakabayashi, H; Yachida, S | 1 |
Dangerfield, J; Nourshargh, S; Voisin, MB; Wang, S; Young, RE | 1 |
Funakoshi, Y; Ishizaka, A; Katori, N; Kawabata, K; Kotake, Y; Morisaki, H; Nakamura, N; Suzuki, T; Takeda, J; Yajima, S; Yamada, S | 1 |
Hato, F; Kato, N; Kato, T; Kitagawa, S; Kodama, T; Yukioka, H | 1 |
Hida, N; Horiuchi, N; Kunikane, H; Naoki, K; Narita, Y; Okamoto, H; Watanabe, K | 1 |
Kobayashi, K; Kotani, Y; Nishimura, Y; Nishiuma, T; Sakashita, A; Takenaka, K; Yokoyama, M | 1 |
Kozawa, S; Miyazawa, N; Nakamura, M; Ogura, T; Tagawa, A; Takahashi, H; Watanuki, Y | 1 |
Hanada, N; Hori, K; Kusano, S; Momi, H | 1 |
Date, H; Kotani, K; Mori, H; Nagahiro, I; Nakanishi, H; Osaragi, T; Sano, Y; Shimizu, N | 1 |
Ai, S; Cheng, XW; Iguchi, A; Inoue, A; Kuzuya, M; Murohara, T; Nakamura, K; Okumura, K | 1 |
Funakoshi, Y; Hashimoto, S; Ishizaka, A; Kitagawa, Y; Kitajima, M; Maruyama, I; Miyasho, T; Okamoto, M; Ozawa, S; Saikawa, Y; Suda, K; Tasaka, S; Ueda, M; Yamada, S; Yokota, H | 1 |
Furuya, H; Morioka, M; Morooka, T; Nomura, Y | 1 |
Aoki, H; Endo, S; Inoue, Y; Kojika, M; Nakadate, T; Sato, N; Suzuki, Y; Yaegashi, Y; Yamada, Y; Yoshida, Y | 1 |
Inomata, T; Narabayashi, I; Shimbo, T; Sonobe, H; Takahashi, M; Tatsumi, T; Uesugi, Y | 1 |
Kono, T; Okada, S; Saito, M | 1 |
Fujita, T; Kumasaka, R; Murakami, R; Nakamura, N; Okumura, K; Osawa, H; Shimada, M; Yamabe, H | 1 |
Hara, S; Kubota, M; Kuno, M; Nemoto, K; Ninomiya, N; Yamamoto, Y | 1 |
Iwasaki, Y; Kubota, K; Okada, T; Sawada, T; Shimoda, M | 1 |
Iwasaki, T; Kimura, H; Kitada, S; Maekura, R; Mori, M; Naka, N; Nakagawa, M; Nakazawa, Y; Namba, Y; Niinaka, M; Okada, T; Yano, Y; Yokota, S | 1 |
Amaya, F; Funakoshi, Y; Hashimoto, S; Ishizaka, A; Kawabata, K; Kimura, A; Okayama, Y; Shime, N | 1 |
Harada, H; Iwasaki, H; Kunisawa, T; Kurosawa, A; Nagashima, M; Takahashi, K; Takahata, O | 1 |
Ehara, N; Fukushima, K; Izumikawa, K; Kakeya, H; Kohno, S; Saito, A; Seki, M; Yamamoto, Y; Yanagihara, K | 1 |
Guo, F; Kishi, H; Kobayashi, S; Maeda, Y; Matsuo, S; Mitsumizo, S; Nakashima, M | 1 |
Kapoor, S | 1 |
Kunihara, T; Matsui, Y; Matsuzaki, K; Murashita, T; Shiiya, N; Shingu, Y | 1 |
Hagiwara, S; Iwasaka, H; Noguchi, T; Togo, K | 1 |
Chida, K; Fujisawa, T; Harada, M; Imokawa, S; Mori, K; Sagisaka, S; Sano, T; Suda, T; Uchiyama, H; Ukita, T; Yasuda, K | 1 |
Ando, M; Murai, T; Takahashi, Y | 1 |
Hiroshima, K; Iyoda, A; Moriya, Y; Shibuya, K; Yoshino, I | 1 |
Dardik, A; Kainuma, M; Kondo, Y; Muto, A; Nishibe, T; Ohara, Y; Takeda, K | 1 |
Asano, M; Matsumori, M; Morimoto, K; Morimoto, N; Morimoto, Y; Okada, K; Okita, Y; Takahashi, H | 1 |
Hagio, T; Hasegawa, N; Hashimoto, S; Ishizaka, A; Kawabata, K; Kishikawa, K; Tasaka, S | 1 |
Hatori, F; Shimizu, A; Takagi, T; Toyama, S | 1 |
Izumikawa, K; Kakeya, H; Kohno, S; Mukae, H; Nakamura, S; Seki, M; Tashiro, T; Yamamoto, Y; Yanagihara, K | 1 |
Gondo, T; Hirata, T; Ishida, K; Matayoshi, H; Matsumoto, M; Mizukami, Y; Sakabe, T; Yamashita, S | 1 |
Hagiwara, S; Hasegawa, A; Hidaka, S; Iwasaka, H; Noguchi, T | 1 |
Bessho, R; Fujii, M; Kambe, M; Ochi, M; Shimizu, K | 1 |
Goto, M; Higashi, A; Iguro, Y; Iwamoto, S; Sakata, R; Ueno, T | 1 |
Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Matsumoto, S; Noguchi, T; Shingu, C | 1 |
Abe, T; Akita, T; Oshima, H; Ueda, Y; Usui, A | 1 |
Fukunaga, K; Kondo, T; Matsuo, R; Murata, S; Nakano, Y; Ohkohchi, N | 1 |
Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T | 1 |
Fujimura, T; Funaki, H; Fushida, S; Inaba, H; Kawahara, Y; Kayahara, M; Nakagawara, H; Ninomiya, I; Oyama, K; Tajima, H; Takamura, H | 1 |
Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H | 1 |
Kang, CM; Kim, YK; Moon, HS; Park, SH; Rhee, CK; Song, JS; Yoon, HK | 1 |
Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Koga, H; Matsumoto, S; Noguchi, T; Shingu, C; Yokoi, I | 1 |
Busuttil, RW; Freitas, MC; Kupiec-Weglinski, JW; Uchida, Y; Zhao, D | 1 |
Kobayashi, N; Koizumi, T; Kubo, K; Tsushima, K; Urushihata, K; Ushiki, A; Yokoyama, T | 1 |
Fukunaga, K; Kondo, T; Murata, S; Nakano, Y; Oda, T; Ohkohchi, N; Pak, S; Sasaki, R | 1 |
Bessho, R; Fujii, M; Miyagi, Y; Nitta, T; Ochi, M; Shimizu, K | 1 |
Fujita, K; Hata, M; Minami, K; Niino, T; Osaka, S; Sezai, A; Shimura, K; Unosawa, S; Yoshitake, I | 1 |
Akiyama, D; Cho, S; Hara, T; Maekawa, T; Sumikawa, K; Yoshitomi, O | 1 |
Harada, N; Kawai, M; Okajima, K; Takeyama, H | 1 |
Hayashi, S; Ikegame, Y; Iwama, T; Nakashima, S; Yamashita, K; Yoshimura, S | 1 |
Koizumi, T; Kubo, K; Tsushima, K; Yoshikawa, S | 1 |
Dimitriadis, F; Kinoshita, Y; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Shomori, K; Tsounapi, P | 1 |
Kaido, T; Uemoto, S | 1 |
Dohi, M; Doi, K; Fujita, T; Imamura, M; Ishii, T; Noiri, E; Okamoto, K; Yamamoto, K | 1 |
Hao, F; Yan, H; Yang, X; Ye, Q; Zhai, Z; Zhong, B | 1 |
Araki, N; Izumikawa, K; Kakeya, H; Kamihira, S; Kohno, S; Morinaga, Y; Seki, M; Yamada, K; Yamada, Y; Yamamoto, Y; Yanagihara, K | 1 |
Fukatsu, K; Maeshima, Y; Omata, J; Saitoh, D; Tanabe, K; Yasuhara, H | 1 |
Endo, S; Inada, K; Shibata, S; Shioya, N; Takahashi, G | 1 |
Harada, N; Harimoto, N; Kakeji, Y; Koga, T; Maehara, Y; Miyazaki, M; Morita, M; Nagata, S; Oki, E; Saeki, H | 1 |
Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K | 1 |
Araki, Y; Kaibori, M; Kwon, AH; Matsumiya, M; Matsuura, T; Nishizawa, M; Okumura, T | 1 |
Masaoka, N; Nakajima, Y; Watanabe, M | 1 |
Iwahashi, M; Naka, T; Nakamori, M; Nakamura, M; Ojima, T; Yamaue, H | 1 |
Aikawa, N; Endo, S; Hirasawa, H; Ikeda, T; Ishizaka, A; Kawasaki, Y; Shimazaki, S; Shinozaki, M; Sugimoto, H; Taenaka, N; Yamamoto, Y | 1 |
Akiyama, H; Endo, I; Kosaka, T; Kunisaki, C; Makino, H; Morita, S | 1 |
Inada, E; Iwanuma, Y; Kajiyama, Y; Kugimiya, T; Kumakura, S; Nagaoka, I; Sugasawa, Y; Takeuchi, K; Tsurumaru, M; Yamaguchi, K | 1 |
Fujishima, S; Hayashida, K; Hori, S; Kitano, M; Orita, T; Sasao, K; Toyoda, Y | 1 |
Costa, E; Guedes, RC; Lucas, SD; Moreira, R | 1 |
Amemori, H; Maeda, Y; Nakashima, M; Torikai, A | 1 |
Churg, A; Ekholm, K; Falk-Håkansson, H; Gränse, M; Jungar, C; Kozma, V; Lal, H; Lindahl, M; Ottosson, T; Sanfridson, A; Stevens, T; Wright, JL | 1 |
Maeta, H; Miyasaka, S; Morimoto, K; Nishimura, K; Taniguchi, I | 1 |
Inoue, T; Kano, H; Okada, K; Okita, Y; Omura, A; Sakamoto, T; Tanaka, A | 1 |
Fujino, N; He, M; Kubo, H; Ota, C; Suzuki, T; Takahashi, T; Yamada, M; Yamaya, M | 1 |
Ando, S; Hirasawa, M; Makuuchi, H; Matsuda, M; Nishiyama, J; Suzuki, T | 1 |
Miao, QB; Shu, YS; Tao, W; Zhu, YB | 1 |
Futamura, M; Kawaguchi, Y; Morimitsu, K; Nawa, M; Nonaka, K; Osada, S; Yoshida, K | 1 |
Chen, HI; Kao, SJ; Lin, CC; Liu, PH | 1 |
Bhattacharya, K; Khatua, B; Mandal, C | 1 |
Axtell, RC; de Jong, BA; Dunn, C; Dunn, J; Goodyear, AL; Han, MH; Herges, K; Killestein, J; Ko, RM; Kolkowitz, I; Maini, A; Mandelbaum, G; Polman, C; Steinman, L | 1 |
Hanazaki, K; Kobayashi, M; Okabayashi, T; Shiga, M; Sugimoto, T; Takezaki, Y; Tsujii, S | 1 |
Fukuda, T; Ishii, Y; Takemasa, A | 1 |
Bao, R; Chen, H; Deng, X; Hou, J; Li, J; Liu, Y; Sun, L; Wang, J; Yang, T; Zhang, J; Zhu, X | 1 |
Feng, L; Huang, C; Li, Y; Zhu, W | 1 |
Du, W; Fujimura, N; Itano, O; Kawasako, K; Kitagawa, Y; Kitago, M; Maruyama, I; Matsuda, S; Matsumoto, K; Miyasho, T; Obara, H; Ono, S; Sakamoto, M; Shinoda, M; Suda, K; Takeuchi, H; Tanabe, M; Yagi, H; Yamada, S | 1 |
Masaoka, N; Nakajima, Y | 1 |
Fox, J; Haston, CK | 1 |
Cai, JH; Chai, JK; Chi, YF; Deng, HP; Feng, R; Hu, QG; Liu, W; Ma, L; Shen, CA; Yin, HN; Zhang, XB; Zou, XF | 1 |
Chen, L; Tang, AM; Wang, HH; Zhou, MT | 1 |
Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E | 1 |
Abe, C; Binh, NH; Cuong, NT; Hara, A; Morita, H; Ogura, S | 1 |
Fuchimoto, Y; Gelfand, EW; Ikeda, G; Kanehiro, A; Kataoka, M; Koga, H; Miyahara, N; Ono, K; Tanimoto, M; Tanimoto, Y; Waseda, K | 1 |
Akita, K; Inomata, T; Narumi, Y; Okada, Y; Shimbo, T; Takahashi, M; Uesugi, Y; Yoshikawa, N | 1 |
Baba, H; Baba, Y; Hirashima, K; Iwatsuki, M; Karashima, R; Kinoshita, K; Kurashige, J; Nagai, Y; Watanabe, M | 1 |
Hwang, JJ; Kim, DH; Kim, KD; Lee, SK; Son, BS | 1 |
Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T | 1 |
Angelos, MG; Aune, SE; Khan, M; Kuppusamy, ML; Kuppusamy, P; Yeh, ST | 1 |
Fujishima, S; Izumida, H | 1 |
Inoue, N; Itatani, K; Kitamura, T; Miyaji, K; Oka, N; Shibata, K; Tomoyasu, T | 1 |
Cao, J; Liu, Q | 1 |
Gao, YM; Hu, XX; Liu, BZ; Ma, PP; Wang, H; Zhang, X; Zhong, L; Zhu, D; Zhu, XY | 1 |
Fujii, M; Hanayama, N; Inoue, N; Itatani, K; Kitamura, T; Kohira, S; Miyaji, K; Oka, N; Oshima, H; Takeda, A; Tojo, K; Yoshitake, S | 1 |
Eguchi, T; Hamanaka, K; Hasegawa, J; Koizumi, T; Komatsu, Y; Kondo, R; Kubo, K; Shiina, T; Yamamoto, H; Yoshida, K | 1 |
Fukuda, K; Kawakubo, H; Kitagawa, Y; Kumagai, K; Miyasho, T; Nakamura, R; Saikawa, Y; Suda, K; Takahashi, T; Takeuchi, H; Wada, N | 1 |
Asano, M; Mishima, A; Nakayama, T; Nomura, N; Saito, T | 1 |
Choi, SY; Kim, H; Park, JS; Park, KH | 1 |
Fujimura, T; Fushida, S; Hayashi, H; Kitagawa, H; Makino, I; Miyashita, T; Munesue, S; Nakagawara, H; Nakanuma, S; Ohta, T; Saito, H; Sakai, S; Tajima, H; Yamamoto, Y | 1 |
Chen, K; Feng, L; Guo, F; Huang, C; Li, Y; Liu, X; Wang, R; Wu, Y; Zhu, W | 1 |
Chang, J; Chen, CH; Cheng, CC; Ho, AS; Lien, GS; Lin, HC; Luo, TY; Wang, CC | 1 |
Fang, QH; Jiang, YW; Yuan, Q | 1 |
Ito, H; Nakayama, H; Yamada, K; Yokose, T | 1 |
Hayashi, N; Matsumoto, S; Okamoto, H; Otsuka, T; Sakai, M; Takenami, T; Yoshino, K | 1 |
Katakura, K; Ohira, H; Shioya, Y | 1 |
Horai, T; Inoue, N; Itatani, K; Kitamura, T; Kohira, S; Miyaji, K; Oka, N; Oshima, H; Tojo, K; Yoshitake, S | 1 |
Chen, L; Gong, H; Ma, P; Tang, A; Wang, H; Wang, S | 1 |
Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H | 1 |
Aibiki, M; Dote, K; Hamada, H; Higaki, J; Ito, R; Katayama, H; Miyoshi, S; Okura, T | 1 |
Cai, J; Chen, LQ; Niu, ZX; Wang, WP; Wang, ZQ; Yang, YS; Yuan, Y | 1 |
Belcastro, R; Jankov, RP; Kantores, C; Li, J; Lopez, L; Masood, A; Tanswell, AK; Yi, M | 1 |
Bo, R; Hasegawa, Y; Ishige, N; Kobayashi, H; Nakamura, M; Takahashi, T; Yamada, K; Yamaguchi, S | 1 |
Dimitriadis, F; Hikita, K; Honda, M; Muraoka, K; Saito, M; Sejima, T; Shimizu, S; Sofikitis, N; Takenaka, A; Tomita, S; Tsounapi, P | 1 |
Carneiro, FS; de Caux, TR; Galvão, I; Lima, GL; Lima, KM; Nunes, FF; Perretti, M; Pinho, V; Ribeiro, AL; Sousa, LP; Sugimoto, MA; Tavares, LP; Teixeira, MM; Vago, JP | 1 |
Chen, XY; Dai, XJ; Wang, J; Wu, YL; Zhang, YF; Zhong, DF | 1 |
Huang, P; Li, QG; Xiao, XG; Zu, HG | 1 |
Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S | 1 |
Dong, HL; Huo, J; Ma, R; Su, BX; Zhu, XL | 1 |
Liu, J; Liu, Y; Luo, Y; Ma, X; Shi, J; Wang, L; Xun, Y; Yang, W; Ye, D; Zang, S; Zhao, F; Zhu, G; Zhuang, Z | 1 |
Guo, Y; Li, T; Ma, L; Sun, R; Zhang, F | 1 |
Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X | 1 |
Imai, Y; Kawahara, M; Kuba, K; Mizushima, T; Sugizaki, T; Tamura, F; Tanaka, KI | 1 |
Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K | 1 |
Kim, IK; Kim, JW; Lee, DG; Lee, HY; Lee, JM; Lee, SH; Rhee, CK; Yeo, CD | 1 |
Imamura, T; Inoue, S; Kawaguchi, M; Kishimoto, M; Matsui, H; Myojin, T; Noda, T; Yamana, H; Yasunaga, H | 1 |
Arimura-Omori, M; Hamada, N; Harada, E; Ikeda-Harada, C; Mikumo, H; Nakanishi, Y; Ogata-Suetsugu, S; Suzuki, K; Yanagihara, T; Yokoyama, T | 1 |
Ando, K; Fukui, M; Matsunaga, T; Oh, S; Suzuki, K; Takamochi, K | 1 |
Krustev, E; McDougall, JJ; Muley, MM; Reid, AR | 1 |
Bali, KK; Kuner, R | 1 |
Bonno, M; Hokuto, I; Iida, K; Ito, M; Kageyama, M; Kato, Y; Matsumoto, N; Mori, R; Nakata, Y; Namba, F; Nishimura, Y; Ogawa, R; Oshiro, M; Takahashi, N; Tanaka, T; Uchida, Y | 1 |
Arakaki, R; Kise, Y; Kuniyoshi, Y; Yamashiro, S | 1 |
Bajorath, J; Blaut, M; Braune, A; Gilberg, E; Girbl, T; Gütschow, M; Nourshargh, S; Schulz-Fincke, AC; Tikhomirov, AS | 1 |
Attia, Z; Boyaka, PN; Cormet-Boyaka, E; Hassan, H; Kim, E; Rowe, JC; Satoskar, AR; Steiner, HE; Varikuti, S; Zaghawa, A | 1 |
Domon, H; Hiyoshi, T; Kawabata, S; Maekawa, T; Nagai, K; Oda, M; Takeda, W; Tamura, H; Terao, Y; Yamaguchi, M; Yonezawa, D | 1 |
Azuma, A; Bando, M; Date, H; Ebina, M; Fukuoka, J; Gemma, A; Goto, Y; Hasegawa, Y; Hattori, N; Homma, S; Inase, N; Inoue, Y; Ishii, Y; Izumi, S; Johkoh, T; Kido, T; Kishaba, T; Kishi, K; Miyamoto, A; Mukae, H; Nakayama, T; Nishioka, Y; Ogura, T; Sakamoto, S; Sasaki, S; Suda, T; Sugino, K; Taguchi, Y; Takahashi, H; Takahashi, K; Taniguchi, H; Watanabe, K; Yokoyama, A; Yoshino, I | 1 |
Dai, J; Fu, Z; Hu, J; Liu, E; Liu, J; Luo, Z; Niu, C; Tian, D; Wang, T; Xiong, Y; Ying, L; Zhang, M; Zou, L; Zou, W | 1 |
Ban, E; Bonanomi, D; Choi, H; Han, I; Jo, MJ; Joshi, HP; Kim, A; Kim, KT; Kim, SB; Kumar, H; Lee, SH; Muttigi, M; Sohn, S; Zeng, X | 1 |
Cai, J; Chen, J; Guan, J; Han, X; Hei, Z; Wu, S; Yao, W; Yuan, D | 1 |
Ageyama, N; Goto, Y; Hiramatsu, Y; Kitazawa, S; Mathis, BJ; Matsubara, M; Sakamoto, H; Sato, S; Sato, Y | 1 |
Kawakami, K; Kawasaki, Y; Kuwauchi, A; Nahara, I; Takeda, C; Takeuchi, M; Tanaka, S; Yonekura, H; Yoshida, S | 1 |
Bi, HW; Li, J; Zhang, GR; Zheng, JQ | 1 |
Domon, H; Hiyoshi, T; Maekawa, T; Miyoshi, T; Nagai, K; Tabeta, K; Takahashi, N; Tamura, H; Terao, Y; Yonezawa, D; Yoshida, A | 1 |
Ebata, R; Hamada, H; Hanaoka, H; Higashi, K; Homma, J; Kobayashi, H; Kohno, Y; Nagai, K; Okunushi, K; Saito, N; Saito, Y; Shimojo, N; Takada, N; Takechi, F; Yasukawa, K | 1 |
Fukuta, T; Kawaguchi, T; Kuroda, A; Maekawa, Y; Matsuo, S; Miyazaki, N; Morishita, K; Oda, K; Ogura, S; Okada, H; Sampei, S; Suzuki, K; Takada, C; Takemura, G; Tomita, H; Uchida, A; Ushikoshi, H; Watanabe, T; Yano, H; Yoshida, S; Yoshida, T; Zaikokuji, R | 1 |
Hayashi, H; Horinokita, I; Mizumura, R; Oteki, R; Takagi, N; Usui, A; Yamaguchi, T; Yuan, B | 1 |
Doi, T; Fukuda, H; Fukuta, T; Hotta, Y; Kuroda, A; Maekawa, Y; Matsuo, S; Miyazaki, N; Morishita, K; Muraki, I; Nishio, A; Oda, K; Ogura, S; Okada, H; Sampei, S; Suzuki, A; Suzuki, K; Takada, C; Takemura, G; Tomita, H; Uchida, A; Ushikoshi, H; Watanabe, T; Yamada, N; Yano, H; Yoshida, S; Yoshida, T; Zaikokuji, R | 1 |
Bessho, R; Fujii, M | 1 |
Colle, I; Debacker, PJ; Devisscher, L; Geerts, A; Lefere, S; Raevens, S; Van Campenhout, S; Van Vlierberghe, H; Verhelst, X | 1 |
Cheng, IY; Ho, WC; Hsu, HS; Hsu, JW; Hsu, TW; Hung, SC; Li, AF; Lin, JH; Liu, CC | 1 |
Arai, H; Ishikawa, Y; Ito, H; Maehara, T; Masuda, M; Morita, S; Morohoshi, T; Nagashima, T; Nakayama, H; Nishii, T; Tajiri, M; Watanabe, K; Woo, T; Yamamoto, T; Yokose, T | 1 |
Hu, S; Jin, J; Li, B; Li, T; Liu, Y; Liu, Z; Ma, S; Novakovic, VA; Shi, J; Sun, Q; Tian, J; Zhang, S; Zhao, H; Zhou, P | 1 |
Anahtar, MN; Bhatia, SN; Chan, LW; Hern, KE; Kunz, RR; Ong, TH | 1 |
Becker, C; Benoliel, JJ; Elbim, C; Frère, C; Hémadi, M; Laforge, M; Massaad, C; Nuss, P | 1 |
Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z | 1 |
Al-Rejaie, S; ElMasry, G; Kishk, RM; Kishk, SM; Nafie, MS; Nemr, NA; Simons, C; Yassen, ASA | 1 |
Ahmad, A; Khan, MA; Khan, R; Mishra, RK; Prakash, R; Raza, SS | 1 |
Hayashi, H; Horinokita, I; Ichiyanagi, M; Imamura, Y; Iwatani, Y; Takagi, N; Yoshizawa, R | 1 |
Aykan, S; Colakerol, A; Gonultas, S; Kandırali, E; Kucuk, SH; Ozsoy, S; Semercioz, A; Suzan, S; Temiz, MZ; Yuruk, E | 1 |
Gao, X; Guo, X; Huang, L; Lei, Z; Tian, J; Yang, Y; Zhang, R | 1 |
Cui, Y; Ding, X; Li, H; Liang, H; Liu, S; Sun, T; Sun, Y; Wang, D; Wang, H; Zhang, X | 1 |
Banno-Terada, R; Endo, M; Fujii, T; Kohno, T; Maekawa, A; Mamiya, R; Nagi-Miura, N; Ohno, N; Takada, M; Takagaki, N; Tanaka, A; Tsuji, T; Yamada, A; Yoshida, Y | 1 |
Dong, T; Tian, W | 1 |
14 review(s) available for sivelestat and glycine
Article | Year |
---|---|
[Pathophysiology of acute lung injury].
Topics: Acute Disease; Animals; Biomarkers; Capillary Permeability; Cell Adhesion Molecules; Clinical Trials as Topic; Glycine; Humans; Leukocyte Elastase; Lung; Lung Diseases; Nitric Oxide; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
[How can we monitor and treat patients with acute exacerbations of idiopathic interstitial pneumonia].
Topics: Acute-Phase Reaction; Anti-Inflammatory Agents; Antigens; Antigens, Neoplasm; Biomarkers; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Glycine; Glycoproteins; Humans; Lung Diseases, Interstitial; Methylprednisolone; Monitoring, Physiologic; Mucin-1; Mucins; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation].
Topics: Animals; Antineoplastic Agents; Bleomycin; Drug Administration Schedule; Glycine; Humans; Lung Diseases, Interstitial; Lung Neoplasms; Methylprednisolone; Mice; Prednisolone; Pulmonary Fibrosis; Radiation Injuries; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
[The 74th Annual Meeting President Lecture. Pathogenesis and therapy of acute lung injury].
Topics: Glycine; Humans; Leukocyte Elastase; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides | 1999 |
[Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate].
Topics: Animals; Clinical Trials, Phase III as Topic; Disease Models, Animal; Glycine; Humans; Leukocyte Elastase; Serpins; Sulfonamides; Systemic Inflammatory Response Syndrome | 2003 |
Update in ARDS management: recent randomized controlled trials that changed our practice.
Topics: Glycine; High-Frequency Ventilation; Humans; Liquid Ventilation; Nitric Oxide; Ohio; Positive-Pressure Respiration; Prone Position; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Tidal Volume | 2006 |
[Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports].
Topics: Aged; Aged, 80 and over; Female; Glycine; Humans; Male; Middle Aged; Pneumonia, Aspiration; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Ventilator Weaning | 2006 |
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
Topics: Acute Lung Injury; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sulfonamides | 2010 |
Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase.
Topics: Enzyme Inhibitors; Glycine; Humans; Molecular Weight; Proteinase Inhibitory Proteins, Secretory; Pulmonary Disease, Chronic Obstructive; Serine Proteinase Inhibitors; Sulfonamides | 2013 |
[Pharmacological therapies for ARDS].
Topics: Animals; Anticoagulants; Atracurium; Disseminated Intravascular Coagulation; Glycine; Humans; Meta-Analysis as Topic; Methylprednisolone; Neuromuscular Blocking Agents; Protein C; Proteinase Inhibitory Proteins, Secretory; Pulse Therapy, Drug; Randomized Controlled Trials as Topic; Recombinant Proteins; Respiratory Distress Syndrome; Sulfonamides | 2013 |
Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: a systematic review and meta-analysis.
Topics: Acute Lung Injury; Aged; Esophagectomy; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Odds Ratio; Respiration, Artificial; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome | 2015 |
[Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis].
Topics: Acute Lung Injury; China; Glycine; Humans; Intensive Care Units; Length of Stay; Prognosis; Randomized Controlled Trials as Topic; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides | 2015 |
Japanese guideline for the treatment of idiopathic pulmonary fibrosis.
Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Comorbidity; Disease Progression; Drug Therapy, Combination; Evidence-Based Medicine; Glycine; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Indoles; Japan; Lung Neoplasms; Meta-Analysis as Topic; Practice Guidelines as Topic; Prognosis; Pyridones; Quality of Health Care; Sulfonamides; Survival Rate | 2018 |
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
Topics: Acute Lung Injury; COVID-19; COVID-19 Drug Treatment; Disseminated Intravascular Coagulation; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sulfonamides; Treatment Outcome | 2020 |
28 trial(s) available for sivelestat and glycine
Article | Year |
---|---|
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.
Topics: Australia; Belgium; Canada; Double-Blind Method; Female; Follow-Up Studies; Glycine; Guideline Adherence; Humans; Infusions, Intravenous; Leukocyte Elastase; Male; Middle Aged; New Zealand; Outcome and Process Assessment, Health Care; Prospective Studies; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Spain; Sulfonamides; Survival Analysis; Tidal Volume; Time; Treatment Outcome; United States | 2004 |
Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.
Topics: Adult; Aged; Cytokines; Double-Blind Method; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Pilot Projects; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides | 2004 |
Relationship between neutrophil elastase and acute lung injury in humans.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glycine; Humans; Intensive Care Units; Length of Stay; Leukocyte Elastase; Male; Middle Aged; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Ventilator Weaning | 2004 |
[Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].
Topics: Cytokines; Esophageal Neoplasms; Esophagectomy; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Lung Diseases; Postoperative Complications; Postoperative Period; Respiration, Artificial; Serpins; Sulfonamides; Time Factors | 2005 |
Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
Topics: Acute Disease; Aged; Cardiopulmonary Bypass; Female; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Perfusion; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2006 |
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
Topics: Adult; Aged; APACHE; C-Reactive Protein; Cell Membrane; Elasticity; Female; Glycine; Humans; Leukocyte Count; Leukocyte Elastase; Leukocytes; Lung; Lung Injury; Male; Microcirculation; Middle Aged; Norepinephrine; Oxygen; Positive-Pressure Respiration; Respiratory Distress Syndrome; Rheology; Sulfonamides; Systemic Inflammatory Response Syndrome; Total Lung Capacity | 2006 |
Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.
Topics: Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Digestive System Neoplasms; Digestive System Surgical Procedures; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Leukocyte Elastase; Liver Neoplasms; Male; Middle Aged; Pancreaticoduodenectomy; Postoperative Period; Prospective Studies; Serine Proteinase Inhibitors; Single-Blind Method; Stress, Physiological; Sulfonamides; Th1 Cells; Th2 Cells | 2007 |
Neutrophil elastase as a predicting factor for development of acute lung injury.
Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Predictive Value of Tests; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2007 |
Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction.
Topics: Acute Disease; Adolescent; Adult; Aged; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Leukocytes; Middle Aged; Oxygen; Pulmonary Circulation; Pulmonary Surfactant-Associated Protein D; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Systemic Inflammatory Response Syndrome; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
[Effect of sivelestat sodium on acute lung injury after acute aortic dissection].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aortic Aneurysm; Aortic Dissection; Female; Glycine; Humans; Infusions, Intravenous; Leukocyte Elastase; Logistic Models; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Respiratory Insufficiency; Sulfonamides | 2008 |
A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery.
Topics: Aged; Atrial Fibrillation; Cardiopulmonary Bypass; Coronary Artery Bypass; Feasibility Studies; Female; Glycine; Humans; Infusions, Intravenous; Length of Stay; Leukocyte Elastase; Lung Compliance; Lung Injury; Male; Middle Aged; Pilot Projects; Pulmonary Circulation; Serine Proteinase Inhibitors; Sulfonamides; Surgical Wound Infection; Time Factors; Treatment Outcome | 2009 |
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
Topics: Acute Lung Injury; Aged; Double-Blind Method; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Male; Middle Aged; Perioperative Care; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgery, Video-Assisted | 2010 |
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
Topics: Acute Lung Injury; Aged; Anti-Inflammatory Agents; Aortic Valve; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cardiopulmonary Bypass; Female; Glycine; Heart Valve Prosthesis Implantation; Humans; Inflammation Mediators; Infusions, Intravenous; Interleukin-6; Interleukin-8; Leukocyte Elastase; Lung; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Pulmonary Gas Exchange; Sulfonamides; Time Factors; Treatment Outcome | 2010 |
Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.
Topics: Acute Lung Injury; Glycine; Humans; Infusions, Intravenous; Leukocyte Elastase; Liver Transplantation; Pilot Projects; Prospective Studies; Protease Inhibitors; Sulfonamides; Time Factors; Treatment Outcome | 2010 |
Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy.
Topics: Aged; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Lung Diseases; Male; Middle Aged; Postoperative Care; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 2011 |
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.
Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Infusions, Intravenous; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Systemic Inflammatory Response Syndrome; Ventilator Weaning | 2011 |
Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.
Topics: Aged; Critical Care; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Intraoperative Care; Length of Stay; Lymph Node Excision; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Thoracic Surgery, Video-Assisted | 2011 |
Effects of sivelestat on bronchial inflammatory responses after esophagectomy.
Topics: Acute Lung Injury; Aged; Bronchitis; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Postoperative Complications; Premedication; Respiratory Distress Syndrome; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2011 |
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
Topics: Aged; Aged, 80 and over; Aorta, Thoracic; Chi-Square Distribution; Female; Glycine; Hospital Mortality; Humans; Hypothermia, Induced; Infusions, Parenteral; Intensive Care Units; Japan; Length of Stay; Leukocyte Elastase; Lung; Male; Respiration, Artificial; Respiratory Insufficiency; Serine Proteinase Inhibitors; Severity of Illness Index; Sulfonamides; Time Factors; Treatment Outcome; Vascular Surgical Procedures; Ventilator Weaning | 2011 |
The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection.
Topics: Aged; Biomarkers; Drug Administration Schedule; Female; Glycine; Hepatectomy; HMGB1 Protein; Humans; Interleukin-6; Leukocyte Elastase; Liver; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2012 |
Neutrophil elastase inhibitor sivelestat attenuates perioperative inflammatory response in pediatric heart surgery with cardiopulmonary bypass.
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Female; Glycine; Humans; Infant; Inflammation; Male; Neutrophils; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2013 |
Effect of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass: a prospective randomized study.
Topics: Age Factors; Anti-Inflammatory Agents; Blood Coagulation; Blood Loss, Surgical; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Elective Surgical Procedures; Glycine; Humans; Infant; Inflammation; Inflammation Mediators; Infusions, Intravenous; Japan; Leukocyte Count; Leukocyte Elastase; Platelet Count; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome | 2013 |
Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung re-expansion following one-lung ventilation during thoracic surgery.
Topics: Actin Cytoskeleton; Actins; Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Interleukin-8; Lung; Male; Malondialdehyde; Middle Aged; Neutrophils; One-Lung Ventilation; Oxygen; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgical Procedures | 2013 |
Sivelestat attenuates lung injury in surgery for congenital heart disease with pulmonary hypertension.
Topics: Blood Pressure; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Glycine; Heart Septal Defects, Ventricular; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Intraoperative Period; Lung Injury; Male; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome; Vascular Resistance | 2013 |
Prophylaxis for acute exacerbation of interstitial pneumonia after lung resection.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Glucocorticoids; Glycine; Humans; Idiopathic Interstitial Pneumonias; Infusions, Intravenous; Injections, Intravenous; Japan; Lung Neoplasms; Male; Methylprednisolone; Middle Aged; Pilot Projects; Pneumonectomy; Preoperative Care; Prospective Studies; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias.
Topics: Aged; Biomarkers; Female; Glycine; Humans; Idiopathic Interstitial Pneumonias; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Perioperative Care; Pneumonectomy; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Secondary Prevention; Sulfonamides; Survival Analysis | 2017 |
Sivelestat sodium hydrate treatment for refractory Kawasaki disease.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Glycine; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant; Male; Mucocutaneous Lymph Node Syndrome; Pilot Projects; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2019 |
A prophylaxis study of acute exacerbation of interstitial pneumonia after lung cancer surgery.
Topics: Aged; Anti-Inflammatory Agents; Female; Glycine; Humans; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Male; Methylprednisolone; Postoperative Complications; Preoperative Care; Prospective Studies; Sulfonamides; Survival Rate; Symptom Flare Up | 2020 |
268 other study(ies) available for sivelestat and glycine
Article | Year |
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Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes.
Topics: Cathepsin G; Cathepsins; Chromatography, High Pressure Liquid; Coumarins; Cytosol; Endothelin-1; Endothelins; Glycine; Humans; Isocoumarins; Leukocyte Elastase; Mass Spectrometry; Neutrophils; Pancreatic Elastase; Protein Precursors; Serine Endopeptidases; Sulfonamides | 1992 |
ONO-5046, a novel inhibitor of human neutrophil elastase.
Topics: Animals; Binding, Competitive; Capillary Permeability; Cricetinae; Glycine; Guinea Pigs; Hemorrhage; Humans; Lung Diseases; Male; Mesocricetus; Mice; Neutrophils; Pancreatic Elastase; Rabbits; Rats; Skin Diseases; Sulfonamides | 1991 |
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Anticoagulants; Antithrombin III; Capillary Permeability; Dansyl Compounds; Endotoxins; Factor Xa; Fibrin Fibrinogen Degradation Products; Glycine; Heparin; Injections, Intravenous; Leukocyte Elastase; Leukopenia; Lipopolysaccharides; Lung; Male; Methotrexate; Molecular Sequence Data; Neutrophils; Pancreatic Elastase; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Wistar; Shock, Septic; Specific Pathogen-Free Organisms; Sulfonamides | 1995 |
A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemotaxis, Leukocyte; Cricetinae; Glycine; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Mesocricetus; Neutrophils; Organ Size; Pancreatic Elastase; Pneumonia; Respiratory Distress Syndrome; Sulfonamides | 1995 |
Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep.
Topics: Airway Resistance; Animals; Antigens; Asthma; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Glycine; Heterocyclic Compounds; Leukocyte Elastase; Leukocytes; Leukotriene B4; Masoprocol; Methacholine Chloride; Pancreatic Elastase; Polycyclic Compounds; Sheep; Sulfonamides; Thromboxane B2 | 1995 |
Substance P stimulates the loss of cell-associated high molecular weight glycoconjugates from cultured hamster tracheal epithelial cells through polymorphonuclear leucocytes activation.
Topics: Animals; Cells, Cultured; Cricetinae; Epithelial Cells; Epithelium; Glycine; Glycoconjugates; Male; Mesocricetus; Molecular Weight; Mucous Membrane; Neutrophil Activation; Pancreatic Elastase; Serine Proteinase Inhibitors; Substance P; Sulfonamides; Trachea | 1995 |
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
Topics: Animals; Ceruletide; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Hemorrhage; Leukocyte Elastase; Lipopolysaccharides; Lung Diseases; Macrophages, Peritoneal; Male; Organ Size; Pancreas; Pancreatic Elastase; Pancreatitis; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 1995 |
Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.
Topics: Animals; Antibody Formation; Arthritis, Experimental; Collagen; Female; Glycine; Immunity, Cellular; Male; Mice; Mice, Inbred DBA; Rats; Rats, Inbred BB; Serine Proteinase Inhibitors; Sulfonamides | 1995 |
Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bacteremia; Blood Gas Analysis; Endotoxins; Escherichia coli Infections; Esterases; Glycine; Hypertension, Pulmonary; Leukocytes; Lung Diseases; Lymph; Neutrophils; Pulmonary Circulation; Sheep; Sulfonamides; Thromboxane B2 | 1994 |
Simultaneous determination of human neutrophil elastase inhibitor (ONO-5046) and its metabolite in plasma and urine by direct injection column-switching HPLC.
Topics: Chromatography, High Pressure Liquid; Glycine; Humans; Leukocyte Elastase; Pancreatic Elastase; Reproducibility of Results; Sulfonamides | 1994 |
Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit.
Topics: Animals; Capillary Permeability; Female; Glycine; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Lung Diseases; Male; Neutrophils; Organ Size; Pancreatic Elastase; Pulmonary Circulation; Pulmonary Edema; Rabbits; Sulfonamides; Superoxide Dismutase; Superoxides | 1994 |
Production of IL-1 and IL-1 receptor antagonist and the pathological significance in lipopolysaccharide-induced arthritis in rabbits.
Topics: Animals; Arthritis; Female; Glycine; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Leukocyte Elastase; Leukopenia; Lipopolysaccharides; Pancreatic Elastase; Proteoglycans; Rabbits; Sialoglycoproteins; Sulfonamides | 1993 |
Interaction between neutrophil-derived elastase and reactive oxygen species in cartilage degradation.
Topics: Animals; Cartilage; Cathepsin G; Cathepsins; Cattle; Cells, Cultured; Enzyme Activation; Glucuronidase; Glycine; Leukocyte Elastase; Luminescent Measurements; Pancreatic Elastase; Rats; Reactive Oxygen Species; Serine Endopeptidases; Sulfonamides | 1993 |
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemotaxis; Escherichia coli; Glycine; Guinea Pigs; In Vitro Techniques; Leukocyte Elastase; Lipopolysaccharides; Lung; Lung Diseases; Male; Neutrophils; Pancreatic Elastase; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Anticoagulants; Antithrombin III; Capillary Permeability; Chemotaxis, Leukocyte; Disseminated Intravascular Coagulation; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Factor Xa; Fibrin Fibrinogen Degradation Products; Fibrinogen; Glycine; Heparin; Leukocyte Elastase; Leukopenia; Lipopolysaccharides; Lung; Male; Molecular Sequence Data; Pancreatic Elastase; Peroxidase; Protein C; Pulmonary Circulation; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Sulfonamides; Thrombin; Tumor Necrosis Factor-alpha | 1996 |
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
Topics: Animals; Chemokines, CXC; Chemotactic Factors; Duodenum; Glycine; Growth Substances; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Male; Pancreas Transplantation; Pancreatic Elastase; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
Effects of neutrophil elastase inhibitor on reperfusion injury in the canine liver.
Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Glycine; Hyaluronic Acid; Ischemia; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver; Pancreatic Elastase; Purine-Nucleoside Phosphorylase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 1996 |
Effects of a specific neutrophil elastase inhibitor (ONO-5046 Na) and neutrophil depletion using a G-1 column on lung reperfusion injury in dogs.
Topics: Animals; Chromatography; Dogs; Glycine; Graft Survival; Ischemia; Leukapheresis; Leukocyte Count; Leukocyte Elastase; Lung; Lung Transplantation; Neutrophils; Pancreatic Elastase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1996 |
Role of granulocyte elastase in the formation of hemorrhagic shock-induced gastric mucosal lesions in the rat.
Topics: Animals; Cells, Cultured; Endothelium, Vascular; Gastric Mucosa; Glycine; Humans; Leukocyte Elastase; Male; Pancreatic Elastase; Phlebotomy; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Shock, Hemorrhagic; Stomach Ulcer; Sulfonamides | 1996 |
Role of granulocyte elastase in ischemia/reperfusion injury of rat liver.
Topics: Animals; Bile; Coloring Agents; Glycine; Indocyanine Green; Leukocyte Elastase; Liver; Male; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Transaminases | 1996 |
Non-peptidic inhibitors of human neutrophil elastase: the design and synthesis of sulfonanilide-containing inhibitors.
Topics: Aniline Compounds; Animals; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Glycine; Guinea Pigs; Humans; Leukocyte Elastase; Male; Neutrophils; Serine Proteinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Sulfonamides | 1996 |
Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver.
Topics: Animals; Antithrombin III; Aspartate Aminotransferases; Chemokines, CXC; Chemotactic Factors; Drug Synergism; Glycine; Growth Substances; Heparin; Intercellular Signaling Peptides and Proteins; Ischemia; Leukocyte Count; Leukocyte Elastase; Liver; Liver Circulation; Male; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidine; Gastric Mucosa; Glycine; Humans; In Vitro Techniques; Indomethacin; Leukocyte Elastase; Male; Neutrophil Activation; Neutrophils; Peroxidase; Quinolones; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
The role of neutrophil elastase in human pulmonary artery endothelial cell injury.
Topics: Endothelium, Vascular; Erythromycin; Glycine; Humans; L-Lactate Dehydrogenase; Leukocyte Elastase; Neutrophils; Pulmonary Artery; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
Leukocyte depletion and ONO-5046, a specific inhibitor of granulocyte elastase, prevent a stress-induced decrease in gastric prostaglandin I2 in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Gastric Mucosa; Glycine; Iloprost; Leukocyte Elastase; Leukocytes; Leukopenia; Male; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Stress, Physiological; Sulfonamides | 1997 |
ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits.
Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Endotoxins; Escherichia coli; Glycine; Hemodynamics; Leukocyte Count; Lung; Lung Compliance; Male; Organ Size; Pancreatic Elastase; Platelet Count; Rabbits; Respiratory Distress Syndrome; Sulfonamides | 1997 |
First-pass metabolism of ONO-5046 (N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino]benzoyl]aminoacetic acid), a novel elastase inhibitor, in rats.
Topics: Animals; Biological Availability; Duodenum; Glycine; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Pancreatic Elastase; Portal Vein; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Bleomycin; Glycine; Leukocyte Elastase; Male; Mice; Neutrophils; Pulmonary Fibrosis; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
[Role of neutrophil elastase in allergen-induced airway microvascular leakage in sensitized guinea pigs].
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Dose-Response Relationship, Drug; Glycine; Guinea Pigs; Humans; Hypersensitivity, Immediate; Leukocyte Count; Leukocyte Elastase; Male; Ovalbumin; Sulfonamides | 1997 |
Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits.
Topics: Animals; Bronchoalveolar Lavage Fluid; Glycine; Hemodynamics; Leukocyte Count; Leukocyte Elastase; Neutrophils; Peroxidase; Pneumonia, Aspiration; Rabbits; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cephalosporins; Cimetidine; Gastric Mucosa; Glycine; Granulocytes; Indomethacin; Leukocyte Elastase; Male; Methotrexate; Microcirculation; Neutrophil Activation; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Specific Pathogen-Free Organisms; Stomach Diseases; Sulfonamides | 1997 |
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Division; Female; Glycine; Humans; Leukocyte Elastase; Lung Neoplasms; Mice; Mice, SCID; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Tumor Cells, Cultured | 1997 |
ONO-5046, an elastase inhibitor, attenuates liver mitochondrial dysfunction after endotoxin.
Topics: Adenosine Diphosphate; Animals; Blood Pressure; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Escherichia coli; Glycine; Guinea Pigs; Ketone Bodies; Leukocyte Elastase; Lipopolysaccharides; Liver Diseases; Male; Mitochondria, Liver; Oxygen; Phosphorylation; Respiration; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Movement; Chemotaxis; Glycine; Humans; Leukocyte Elastase; Pancreatic Neoplasms; Serine Proteinase Inhibitors; Sulfonamides; Tumor Cells, Cultured | 1997 |
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Endothelium, Vascular; Glycine; Humans; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lung Neoplasms; Rats; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
Topics: Animals; Capillary Permeability; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Infusions, Intravenous; Leukocyte Elastase; Neutrophil Activation; Pulmonary Wedge Pressure; Rabbits; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Effect of human neutrophil elastase on tracheal mucociliary transport in anesthetized quails.
Topics: Animals; Bronchoalveolar Lavage Fluid; DNA; Dose-Response Relationship, Drug; Fucose; Glycine; Humans; Leukocyte Elastase; Male; Mucociliary Clearance; Mucous Membrane; Proteins; Quail; Serine Proteinase Inhibitors; Sulfonamides; Trachea | 1997 |
Interleukin-8 as an essential factor in the human chorionic gonadotropin-induced rabbit ovulatory process: interleukin-8 induces neutrophil accumulation and activation in ovulation.
Topics: Animals; Chorionic Gonadotropin; Female; Glycine; Humans; Interleukin-8; Neutrophil Activation; Neutrophils; Ovary; Ovulation; Peroxidase; Rabbits; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Neutrophil elastase inhibitor (ONO-5046.Na) decreases production of proinflammatory cytokines by lipopolysaccharide-stimulated human monocytes.
Topics: Cells, Cultured; Cytokines; Glycine; Humans; Interleukin-1; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Monocytes; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 1997 |
Role of leukotriene B4 in bronchial hyperresponsiveness induced by interleukin-8.
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Glycine; Guinea Pigs; Immunosuppressive Agents; Interleukin-8; Leukocyte Elastase; Leukotriene B4; Male; Neutrophils; Phenylpropionates; Sulfonamides | 1998 |
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Topics: Animals; Antibodies, Heterophile; Basement Membrane; Disease Models, Animal; Glycine; Hematuria; Humans; Kidney Glomerulus; Leukocyte Elastase; Macrophages; Male; Monocytes; Nephritis; Proteinuria; Rats; Rats, Inbred WKY; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver.
Topics: Animals; Drug Stability; Glycine; Half-Life; In Vitro Techniques; Leukocyte Elastase; Liver; Male; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Neutrophil elastase enhances intercellular adhesion molecule-1 expression.
Topics: Animals; Calcium; Cells, Cultured; Endothelium, Vascular; Glycine; Humans; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Male; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Sulfonamides; Type C Phospholipases | 1998 |
ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy.
Topics: alpha 1-Antitrypsin; Glycine; Humans; Leukocyte Elastase; Pleural Effusion; Pneumonectomy; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (1). Single-dose intravenous toxicity studies in rats and dogs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Weight; Bronchi; Dogs; Eating; Female; Glycine; Injections, Intravenous; L-Lactate Dehydrogenase; Lethal Dose 50; Lung; Male; Motor Activity; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (2). 4-week repeated dose intravenous toxicity study in rats with 4-week recovery test].
Topics: Animals; Blood; Body Weight; Eating; Eye; Female; Glycine; Injections, Intravenous; Kidney; Lung; Male; Motor Activity; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1998 |
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). 4-week repeated dose intravenous toxicity study in dogs with 4-week recovery test].
Topics: Animals; Cardiovascular System; Dogs; Erythrocyte Count; Female; Glycine; Injections, Intravenous; Kidney; Lung; Male; No-Observed-Adverse-Effect Level; Organ Size; Retina; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (4). 6-month repeated dose intravenous toxicity study in rats with 1-month recovery test].
Topics: Animals; Blood Cell Count; Female; Glycine; Heart; Injections, Intravenous; Lung; Male; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Urinary Bladder | 1998 |
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (5). 6-month repeated dose intravenous toxicity study in dogs with 1-month recovery test].
Topics: Animals; Body Weight; Dogs; Ear, External; Female; Gait; Glycine; Injections, Intravenous; Male; No-Observed-Adverse-Effect Level; Organ Size; Respiration; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1998 |
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na (1). Fertility study in rats].
Topics: Animals; Body Weight; Embryonic and Fetal Development; Female; Fertility; Glycine; Injections, Intravenous; Male; No-Observed-Adverse-Effect Level; Organ Size; Pituitary Gland; Pregnancy; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (2). Study for effects on pre- and postnatal development in rats, including maternal function
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Female; Glycine; Injections, Intravenous; Learning; Male; No-Observed-Adverse-Effect Level; Organ Size; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Reproduction; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). Teratogenicity study in rabbits].
Topics: Animals; Body Weight; Eating; Embryonic and Fetal Development; Female; Glycine; Injections, Intravenous; No-Observed-Adverse-Effect Level; Pregnancy; Pregnancy, Animal; Rabbits; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
Topics: Animals; Capillary Permeability; Cephalosporins; Disease Models, Animal; Gastric Mucosa; Glycine; Leukocyte Elastase; Leukopenia; Male; Mechlorethamine; Neutrophils; Peptic Ulcer; Peroxidase; Rats; Rats, Wistar; Restraint, Physical; Serine Proteinase Inhibitors; Specific Pathogen-Free Organisms; Stress, Physiological; Sulfonamides | 1998 |
The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs.
Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Endothelium, Vascular; Glycine; Hemorrhage; Hepatectomy; Hyaluronic Acid; Ischemia; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver; Liver Circulation; Portal System; Purine-Nucleoside Phosphorylase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 1999 |
Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
Topics: alpha-Macroglobulins; Amylases; Animals; Blood Pressure; Calcium; Disease Models, Animal; Dogs; Glycine; Hematocrit; Hemorrhage; Leukocyte Count; Lipopolysaccharides; Multiple Organ Failure; Organ Size; Pancreatitis; Serine Proteinase Inhibitors; Sulfonamides | 1998 |
Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways.
Topics: Animals; Anti-Allergic Agents; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Movement; Cyclophosphamide; Dose-Response Relationship, Drug; Glycine; Leukocyte Elastase; Male; Microcirculation; Neutrophils; Phthalazines; Platelet Activating Factor; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Sulfonamides | 1999 |
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Glycine; Hemodynamics; Leukapheresis; Leukocyte Elastase; Lung; Neutrophils; Organ Size; Random Allocation; Recombinant Proteins; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1999 |
Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation.
Topics: Adenine Nucleotides; Animals; Bile; Glycine; Hyaluronic Acid; Ischemia; Leukocyte Elastase; Liver; Liver Circulation; Liver Transplantation; Male; Rats; Rats, Inbred Lew; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1999 |
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Glycine; Hemodynamics; Ischemia; Laser-Doppler Flowmetry; Leukocyte Elastase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Microcirculation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Ultrasonography | 1999 |
Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein- expression after ischemia/reperfusion in rat liver.
Topics: Animals; Antithrombin III; Cell Hypoxia; Cells, Cultured; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glycine; Humans; Hydrogen Peroxide; Ischemia; Kupffer Cells; Leukocyte Elastase; Liver; Macrophages, Peritoneal; Male; Rats; Rats, Wistar; Reperfusion; Serine Proteinase Inhibitors; Sulfonamides; Superoxides; Transcription, Genetic | 1999 |
Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Glycine; Guinea Pigs; Leukocyte Elastase; Male; Oxidants, Photochemical; Ozone; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 1999 |
Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury.
Topics: Animals; Cardiopulmonary Bypass; Dogs; Extravascular Lung Water; Glycine; Hemodynamics; Interleukin-6; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Lung; Oxygen; Protective Agents; Pulmonary Circulation; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance | 1999 |
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
Topics: Animals; Antilymphocyte Serum; Brain Edema; Brain Ischemia; Cell Count; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glycine; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Leukocyte Elastase; Male; Neutrophils; Rats; Rats, Wistar; Rose Bengal; Serine Proteinase Inhibitors; Sulfonamides | 2000 |
Differential modulation of annexin I binding sites on monocytes and neutrophils.
Topics: Amino Acid Sequence; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Endopeptidases; Flow Cytometry; Glycine; Humans; In Vitro Techniques; Molecular Sequence Data; Monocytes; Neutrophils; Peptide Fragments; Peptides; Respiratory Burst; Serine Proteinase Inhibitors; Sulfonamides | 1999 |
Neutrophil elastase inhibitor, ONO-5046 suppresses ozone-induced airway mucus hypersecretion in guinea pigs.
Topics: Animals; Bronchoalveolar Lavage Fluid; Enzyme Inhibitors; Glycine; Glycoproteins; Guinea Pigs; In Vitro Techniques; Leukocyte Elastase; Macrophages, Alveolar; Mucus; Oxidants, Photochemical; Ozone; Respiratory Mucosa; Sulfonamides; Trachea | 2000 |
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cricetinae; Disease Progression; Endotoxins; Glycine; Leukocyte Count; Leukocyte Elastase; Lung; Male; Mesocricetus; Neutrophils; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides | 2000 |
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 2000 |
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa].
Topics: Animals; Disease Models, Animal; Glycine; Hydrochloric Acid; Leukocyte Elastase; Male; Pneumonia, Aspiration; Pneumonia, Bacterial; Pseudomonas Infections; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides | 2000 |
Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat.
Topics: Albumins; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Glycine; Hyperoxia; Leukocyte Elastase; Lung; Lung Diseases; Neutrophils; Rats; Rats, Sprague-Dawley; Sulfonamides; Superoxide Dismutase | 2000 |
Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.
Topics: Cells, Cultured; Drug Combinations; Endothelium, Vascular; Flow Cytometry; Glycine; Glycoproteins; Humans; Interferon-gamma; Interleukin-1; Intracellular Fluid; Leukocyte Elastase; Lipopolysaccharides; Microscopy, Confocal; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Trypsin Inhibitors; Tumor Necrosis Factor-alpha; Umbilical Veins | 2001 |
Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model.
Topics: Animals; Cytokines; Dogs; Glycine; Heart Transplantation; Inflammation Mediators; Leukocyte Elastase; Neutrophil Activation; Reperfusion Injury; Serine Proteinase Inhibitors; Stroke Volume; Sulfonamides; Transplantation, Heterotopic | 2001 |
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Catalase; Complement Activation; Cricetinae; Dose-Response Relationship, Drug; Elapid Venoms; Glycine; Leukocyte Elastase; Lung; Lung Diseases; Male; Mesocricetus; Neutrophils; Peroxidase; Proteins; Serine Proteinase Inhibitors; Sulfonamides; Time Factors | 2001 |
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
Topics: Animals; Blood-Brain Barrier; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Gene Expression; Glycine; Growth Substances; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interleukin-8; Leukocyte Elastase; Motor Activity; Peroxidase; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Serine Proteinase Inhibitors; Spinal Cord; Spinal Cord Injuries; Sulfonamides | 2001 |
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Extravascular Lung Water; Glycine; Growth Substances; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Intestines; Leukocyte Count; Leukocyte Elastase; Lung; Male; Microcirculation; Neutrophil Infiltration; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2001 |
Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.
Topics: Animals; Aspirin; Catalase; Free Radical Scavengers; Gastric Mucosa; Gerbillinae; Glycine; Helicobacter Infections; Helicobacter pylori; Leukocyte Elastase; Male; Peroxidase; Reactive Oxygen Species; Stomach Ulcer; Sulfonamides; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2002 |
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
Topics: Animals; Endothelium, Vascular; Glycine; Humans; Leukocyte Elastase; Oxidative Stress; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Xanthine Oxidase | 2002 |
Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.
Topics: Acylation; Chromatography, High Pressure Liquid; Glycine; Humans; Isoenzymes; Pancreatic Elastase; Serine Proteinase Inhibitors; Spectrometry, Mass, Electrospray Ionization; Sputum; Sulfonamides | 2002 |
Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice.
Topics: Analysis of Variance; Animals; Benzoates; Cytokines; Disease Models, Animal; Drug Interactions; Glycine; Injections, Intravenous; Interleukin-1; Lipopolysaccharides; Liver Circulation; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microcirculation; Microscopy; Probability; Pyrrolidines; Random Allocation; Reference Values; Sensitivity and Specificity; Sulfonamides; Treatment Outcome; Tumor Necrosis Factor-alpha | 2002 |
Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.
Topics: Animals; Glycine; Liver Circulation; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Reperfusion Injury; Serpins; Sulfonamides | 2002 |
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Female; Glycine; Immunohistochemistry; Leukocyte Elastase; Lung Neoplasms; Mice; Mice, SCID; Sulfonamides; Tumor Cells, Cultured | 2003 |
The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.
Topics: Animals; Cardiac Output; Female; Glycine; Leukocyte Elastase; Lung Diseases; Lung Transplantation; Oxygen; Pulmonary Circulation; Pulmonary Wedge Pressure; Rabbits; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance | 2003 |
Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis.
Topics: Female; Glomerulonephritis; Glycine; Humans; Leukocyte Elastase; Middle Aged; Serine Proteinase Inhibitors; Sulfonamides | 2003 |
Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046.
Topics: Animals; Base Sequence; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Glycine; Mice; Mice, Inbred C57BL; Milk Proteins; Pancreatic Elastase; Reverse Transcriptase Polymerase Chain Reaction; STAT5 Transcription Factor; STAT6 Transcription Factor; Sulfonamides; Trans-Activators | 2003 |
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycine; Hemorrhage; Hydrochloric Acid; In Vitro Techniques; Leukocyte Count; Leukocyte Elastase; Lung; Male; Mesocricetus; Neutrophils; Peroxidase; Pneumonia, Aspiration; Respiratory Insufficiency; Sulfonamides; Survival Analysis | 2004 |
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glycine; Humans; Japan; Methylprednisolone; Multicenter Studies as Topic; Periodicals as Topic; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2004 |
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Cephalosporins; Chemokines, CXC; Cyclooxygenase Inhibitors; Endothelium; Enzyme Inhibitors; Epoprostenol; Glycine; Iloprost; Indomethacin; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Liver; Liver Circulation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Transaminases; Vasodilator Agents | 2004 |
[Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy].
Topics: Antigens; Antigens, Neoplasm; Arthritis, Rheumatoid; Biomarkers; Female; Glycine; Glycoproteins; Humans; Leukocyte Elastase; Methylprednisolone; Middle Aged; Mucin-1; Mucins; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein D; Pulse Therapy, Drug; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2004 |
[A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin].
Topics: Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Erythromycin; Glycine; Humans; Infusions, Intravenous; Legionnaires' Disease; Male; Methylprednisolone; Middle Aged; Respiratory Distress Syndrome; Sulfonamides | 2004 |
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
Topics: Acetylglucosaminidase; Animals; Bronchoalveolar Lavage Fluid; Glycine; Ischemia; L-Lactate Dehydrogenase; Lactates; Leukocyte Elastase; Lipid Peroxides; Liver; Luminescent Measurements; Male; Neutrophils; Rabbits; Reperfusion Injury; Serine Proteinase Inhibitors; Stomach; Sulfonamides; Time Factors; Transaminases | 2005 |
Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cost Savings; Female; Glycine; Health Care Costs; Humans; Male; Markov Chains; Middle Aged; Respiratory Distress Syndrome; Sulfonamides; Systemic Inflammatory Response Syndrome | 2005 |
Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
Topics: Acute Disease; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Glycine; Hemorrhage; Injections, Intravenous; Leukocyte Elastase; Lung; Male; Organ Size; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Proteins; Pulmonary Alveoli; Pulmonary Edema; Rabbits; Respiratory Insufficiency; Sulfonamides; Tetradecanoylphorbol Acetate | 2005 |
Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation.
Topics: Actins; CD11b Antigen; Cell Adhesion Molecules; Chemotactic Factors; Chemotaxis, Leukocyte; Extracorporeal Circulation; Glycine; Humans; Inflammation Mediators; Interleukin-8; L-Selectin; Leukocyte Elastase; Models, Cardiovascular; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides | 2005 |
Case with bromine exposure leading to respiratory insufficiency.
Topics: Adult; Bromine; Burns, Chemical; Burns, Inhalation; Glycine; Humans; Inhalation Exposure; Male; Methylprednisolone; Prednisolone; Pulmonary Edema; Respiration, Artificial; Respiratory Insufficiency; Sulfonamides; Volatilization | 2005 |
Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
Topics: Analysis of Variance; Animals; Cell Adhesion; Glycine; Hemodynamics; Leukocyte Elastase; Leukocytes; Lipopolysaccharides; Male; Microcirculation; Microscopy, Polarization; Microscopy, Video; Microspectrophotometry; Pulmonary Circulation; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides | 2005 |
Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients.
Topics: Aged; Aged, 80 and over; Critical Illness; Female; Glycine; Hospitals, University; Hospitals, Urban; Humans; Intensive Care Units; Japan; Length of Stay; Leukocyte Elastase; Male; Middle Aged; Multiple Organ Failure; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Treatment Outcome | 2005 |
[Clinical experience of sivelestat sodium hydrate for severe reexpansion pulmonary edema; report of a case].
Topics: Aged; Aged, 80 and over; Drainage; Glycine; Humans; Male; Methylprednisolone; Pneumothorax; Pulmonary Edema; Pulse Therapy, Drug; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides | 2005 |
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Glycine; Granulocyte Colony-Stimulating Factor; Hydrochloric Acid; Leukocyte Elastase; Lung; Lung Injury; Male; Pneumonia, Aspiration; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors | 2004 |
Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.
Topics: Aged; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2006 |
Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs.
Topics: Animals; Bronchi; Glycine; Guinea Pigs; In Vitro Techniques; Indomethacin; Leukocyte Elastase; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Prostaglandins; Respiratory Mucosa; Respiratory System; Serine Proteinase Inhibitors; Substance P; Sulfonamides; Tachykinins; Trachea | 2005 |
[Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy].
Topics: Acute Disease; Aged; Drug Therapy, Combination; Female; Glycine; Humans; Lung Diseases, Interstitial; Male; Methylprednisolone; Middle Aged; Prednisolone; Respiratory Insufficiency; Serine Proteinase Inhibitors; Sulfonamides | 2006 |
ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits.
Topics: Animals; Brain-Derived Neurotrophic Factor; Caspase 3; Caspases; Cell Death; Extracellular Signal-Regulated MAP Kinases; Glycine; Leukocyte Elastase; Male; Motor Neurons; Phosphorylation; Rabbits; Spinal Cord Ischemia; Sulfonamides; Time Factors | 2006 |
Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.
Topics: Animals; Blood Gas Analysis; Cytokines; Glycine; Lung; Lung Diseases; Male; Pancreatic Elastase; Protease Inhibitors; Rats; Rats, Wistar; Respiration, Artificial; Sulfonamides; Tidal Volume | 2006 |
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
Topics: Adult; Animals; Biomarkers; Cells, Cultured; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Glycine; Humans; Intestinal Mucosa; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides | 2006 |
Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters.
Topics: Acute Disease; Animals; Cricetinae; Glycine; Leukocyte Elastase; Lipopolysaccharides; Male; Microcirculation; Pneumonia; Pulmonary Alveoli; Pulmonary Circulation; Serine Proteinase Inhibitors; Sulfonamides | 2006 |
Application of chemical arrays in screening elastase inhibitors.
Topics: Bromphenol Blue; Catalytic Domain; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Glycine; Kinetics; Pancreatic Elastase; Protein Array Analysis; Sensitivity and Specificity; Substrate Specificity; Sulfonamides | 2006 |
Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.
Topics: Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Endotoxins; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Glycine; Humans; In Vitro Techniques; Interleukin-8; Polymerase Chain Reaction; Pulmonary Alveoli; Respiratory Mucosa; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study].
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Thoracic; Cardiopulmonary Bypass; Female; Glycine; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Proteins; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Systemic Inflammatory Response Syndrome | 2006 |
Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.
Topics: Animals; Carcinoma; ErbB Receptors; Female; Glycine; Humans; Leukocyte Elastase; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 3; Neoplasm Transplantation; Phosphorylation; Serine Proteinase Inhibitors; Stomach Neoplasms; Sulfonamides; Transforming Growth Factor alpha; Xenograft Model Antitumor Assays | 2006 |
Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytoprotection; Dexamethasone; Female; Glycine; Humans; Intracranial Hemorrhages; Leukemia, Promyelocytic, Acute; Male; Prospective Studies; Radiography; Randomized Controlled Trials as Topic; Remission Induction; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tretinoin | 2006 |
The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
Topics: Acute Disease; Aged; Aortic Aneurysm; Aortic Dissection; Cardiopulmonary Bypass; Female; Glycine; Humans; Male; Postoperative Care; Proteinase Inhibitory Proteins, Secretory; Respiratory Insufficiency; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides | 2006 |
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Functional Laterality; Glycine; Leukocyte Elastase; Male; Rats; Rats, Inbred Lew; Renal Artery; Renal Circulation; Renal Veins; Reperfusion Injury; Sulfonamides; Survival Analysis | 2006 |
ICAM-1 signal transduction in cells stimulated with neutrophil elastase.
Topics: alpha 1-Antitrypsin; Animals; Blotting, Northern; Dose-Response Relationship, Drug; Endothelial Cells; Glycine; Immunohistochemistry; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Male; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Sulfonamides | 2006 |
Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate.
Topics: Antitubercular Agents; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Tuberculosis, Miliary | 2006 |
Usefulness of sivelestat sodium administration in patients with aspiration pneumonia.
Topics: Anti-Bacterial Agents; C-Reactive Protein; Child; Child, Preschool; Glycine; Humans; Leukocyte Elastase; Leukocytes; Male; Meropenem; Middle Aged; Pneumonia, Aspiration; Radiography; Serine Proteinase Inhibitors; Sulfonamides; Thienamycins | 2006 |
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).
Topics: Acute Kidney Injury; Adult; Antibodies, Viral; Bronchi; Carcinoma; Combined Modality Therapy; Female; gamma-Globulins; Glycine; Granulocyte Colony-Stimulating Factor; Humans; Immunocompromised Host; Immunosuppressive Agents; Influenza A Virus, H3N2 Subtype; Influenza, Human; Lymphohistiocytosis, Hemophagocytic; Methylprednisolone; Myocarditis; Postoperative Complications; Respiration, Artificial; Respiratory Insufficiency; Sulfonamides; Tongue Neoplasms | 2006 |
Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines.
Topics: Cell Growth Processes; Cell Line, Tumor; Cell Movement; ErbB Receptors; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Glycine; Humans; Leukocyte Elastase; MAP Kinase Signaling System; Platelet-Derived Growth Factor; Sulfonamides; Transforming Growth Factor alpha; Vascular Endothelial Growth Factor A | 2007 |
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].
Topics: Adult; Alcoholism; Feeding and Eating Disorders; Female; Glycine; Humans; Leukocyte Elastase; Malnutrition; Pneumonia, Pneumococcal; Respiratory Distress Syndrome; Sulfonamides | 2006 |
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
Topics: Animals; Cardiopulmonary Bypass; Glycine; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Neutrophils; Peroxidase; Rabbits; Respiratory Distress Syndrome; Sulfonamides | 2007 |
Invited commentary.
Topics: Animals; Cardiopulmonary Bypass; Glycine; Leukocyte Elastase; Lipopolysaccharides; Rabbits; Respiratory Distress Syndrome; Sulfonamides | 2007 |
A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.
Topics: Animals; DNA; Gene Expression Regulation; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lung; Lung Injury; Male; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Protein Binding; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Sulfonamides; Tumor Necrosis Factor-alpha | 2007 |
[A case of idiopathic ARDS treated by sivelestat sodium and fluid management based on extravascular lung water index].
Topics: Aged; Extravascular Lung Water; Female; Fluid Therapy; Glycine; Humans; Leukocyte Elastase; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides | 2006 |
Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Glycine; Hepatectomy; Humans; Leukocyte Elastase; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 2007 |
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
Topics: Animals; Cytokines; Endotoxins; Escherichia coli; Glycine; Injections, Intraperitoneal; Interleukin-8; Leukocyte Elastase; Lung; Lung Transplantation; Male; Neutrophils; Pneumonia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Tissue and Organ Harvesting; Tumor Necrosis Factor-alpha | 2007 |
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
Topics: Animals; Blood; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Female; Glycine; Leukocyte Elastase; Lung; Mice; Mice, Inbred CBA; Pneumonia, Pneumococcal; Serine Proteinase Inhibitors; Streptococcus pneumoniae; Sulfonamides; Survival Rate | 2007 |
Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
Topics: Animals; Basement Membrane; Bone Marrow Cells; Cell Movement; Chemotaxis, Leukocyte; Enzyme Inhibitors; Glycine; Leukocyte Elastase; Leukotriene B4; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neutrophils; Platelet Activating Factor; Sulfonamides; Venules | 2007 |
Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits.
Topics: Acute Disease; Animals; Glycine; HMGB1 Protein; Hypoxia; Intestinal Mucosa; Leukocyte Elastase; Male; Neutrophils; Permeability; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rabbits; Sulfonamides | 2007 |
[A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat].
Topics: Acute Kidney Injury; Glucocorticoids; Glycine; Humans; Legionnaires' Disease; Male; Methylprednisolone; Middle Aged; Respiratory Distress Syndrome; Sulfonamides | 2007 |
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
Topics: Animals; Apoptosis; Blotting, Western; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Chemokines, CXC; Enzyme-Linked Immunosorbent Assay; Glycine; Injections, Intraperitoneal; Interleukin-6; Leukocyte Elastase; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neutrophil Infiltration; Neutrophils; Pulmonary Edema; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha; Ventilators, Mechanical | 2007 |
[Outcome of patients with acute exacerbation of idiopathic interstitial fibrosis (IPF) treated with sivelestat and the prognostic value of serum KL-6 and surfactant protein D].
Topics: Acute Disease; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers; Chronic Disease; Disease Progression; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Mucin-1; Mucins; Pulmonary Fibrosis; Pulmonary Surfactant-Associated Protein D; Respiratory Insufficiency; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2007 |
[Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Drug Administration Schedule; Drug Combinations; Glycine; Humans; Male; Neutropenia; Oxonic Acid; Paclitaxel; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tegafur | 2007 |
Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
Topics: Animals; Glycine; Leukocyte Elastase; Lung; Lung Transplantation; Male; Models, Animal; Organ Preservation; Organ Preservation Solutions; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2007 |
Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase.
Topics: Animals; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Fibroblast Growth Factor 2; Glycine; Humans; In Vitro Techniques; Leukocyte Elastase; Mice; Neovascularization, Physiologic; Sulfonamides; Vascular Endothelial Growth Factor A | 2007 |
Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.
Topics: Aged; Combined Modality Therapy; Enzyme Inhibitors; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Postoperative Period; Sulfonamides; Treatment Outcome | 2007 |
[Case of fulminant idiopathic interstitial pneumonia treated by sodium siverlestat (Elaspol) and steroid pulse therapy following extracorporeal lung assist (ECLA)].
Topics: Extracorporeal Membrane Oxygenation; Glycine; Humans; Lung Diseases, Interstitial; Male; Methylprednisolone; Middle Aged; Pulse Therapy, Drug; Sulfonamides; Treatment Outcome | 2007 |
Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis.
Topics: Animals; Female; Glycine; Leukocyte Elastase; Lung; Mice; Mice, Inbred C57BL; Radiation Pneumonitis; Serine Proteinase Inhibitors; Sulfonamides | 2007 |
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.
Topics: Animals; Glycine; Leukocyte Elastase; Male; Malondialdehyde; Nitrates; Nitrites; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Sulfonamides; Urinary Bladder | 2008 |
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
Topics: Animals; Disease Models, Animal; Glycine; Kidney Glomerulus; Male; Microscopy, Electron; Microscopy, Fluorescence; Nephritis; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Thy-1 Antigens; Treatment Outcome | 2008 |
Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.
Topics: Animals; Consciousness; Gastrointestinal Motility; Glycine; Guinea Pigs; Hypotension; Infusions, Intravenous; Intestinal Diseases; Lipopolysaccharides; Male; Sulfonamides | 2008 |
Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.
Topics: Animals; Aspartate Aminotransferases; Blood Pressure; Cell Line; Enzyme Inhibitors; Glycine; Heart Rate; Hepatectomy; Hepatocytes; In Situ Nick-End Labeling; In Vitro Techniques; Leukocyte Elastase; Lipopolysaccharides; Liver Diseases; Nitric Oxide Synthase Type II; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Sulfonamides; Swine; Tumor Necrosis Factor-alpha | 2008 |
[A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib].
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Gefitinib; Glycine; Humans; Lung Diseases; Lung Neoplasms; Male; Prednisolone; Quinazolines; Serine Proteinase Inhibitors; Sulfonamides | 2008 |
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Topics: Aged; alpha 1-Antitrypsin; Enzyme Inhibitors; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Respiratory Distress Syndrome; Sulfonamides | 2008 |
[Case of severe transfusion-related acute lung injury during coronary artery bypass surgery].
Topics: Aged; Angina Pectoris; Antibodies; Coronary Artery Bypass; Glycine; Granulocytes; HLA Antigens; Humans; Intraoperative Complications; Male; Respiratory Distress Syndrome; Severity of Illness Index; Sulfonamides; Transfusion Reaction | 2008 |
Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.
Topics: Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Erythromycin; Fluoroquinolones; Glycine; Humans; Legionnaires' Disease; Male; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2008 |
Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium; Coronary Vessels; Endothelium, Vascular; Glycine; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Sulfonamides; Swine; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Sivelestat and its role in tissue reperfusion injury.
Topics: Glycine; Humans; Leukocyte Elastase; Lung; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2008 |
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
Topics: Animals; Glycine; HMGB1 Protein; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Lung; Lung Injury; Male; NF-kappa B; Nitrates; Nitrites; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Shock, Septic; Sulfonamides; Tumor Necrosis Factor-alpha | 2008 |
[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate].
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; Drug Therapy, Combination; Ganciclovir; Glycine; Humans; Male; Methylprednisolone; Pneumonia, Pneumocystis; Proteinase Inhibitory Proteins, Secretory; Pulse Therapy, Drug; Respiratory Insufficiency; Severity of Illness Index; Sulfonamides; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2008 |
The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model.
Topics: Animals; Animals, Newborn; Cardiopulmonary Bypass; Disease Models, Animal; Drug Administration Schedule; Glycine; Leukocyte Elastase; Lung; Lung Diseases; Neutrophil Activation; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Swine; Time Factors | 2008 |
Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.
Topics: Adrenal Cortex Hormones; Aged; Drug Therapy, Combination; Glycine; Humans; Lung Neoplasms; Male; Pneumonectomy; Proteinase Inhibitory Proteins, Secretory; Radiography, Thoracic; Respiratory Distress Syndrome; Sulfonamides; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study.
Topics: Acute Disease; Analysis of Variance; Aortic Aneurysm, Thoracic; Aortic Dissection; Cardiopulmonary Bypass; Chi-Square Distribution; Female; Glycine; Humans; Leukocyte Count; Lung Diseases; Male; Pilot Projects; Postoperative Complications; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2008 |
Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.
Topics: Aged; Aged, 80 and over; Aorta, Thoracic; Aortic Aneurysm; Blood Vessel Prosthesis Implantation; C-Reactive Protein; Cardiopulmonary Bypass; Female; Glycine; Hemodynamics; Humans; Hypothermia, Induced; Lung Diseases; Male; Middle Aged; Oxygen; Oxygen Consumption; Partial Pressure; Postoperative Complications; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2008 |
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; Cricetinae; Disease Models, Animal; Glycine; Leukocyte Elastase; Mesocricetus; Pneumonia, Pneumococcal; Proteinase Inhibitory Proteins, Secretory; Pulmonary Surfactant-Associated Protein D; Streptococcus pneumoniae; Sulfonamides; Time Factors | 2008 |
A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass.
Topics: Anesthesia, Inhalation; Cardiopulmonary Bypass; Female; Glycine; Heart; Heart Septal Defects, Ventricular; Hematocrit; Humans; Hypertension, Pulmonary; Infant; Intensive Care Units, Pediatric; Leukocyte Count; Male; Oxygen; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Respiratory Mechanics; Retrospective Studies; Sulfonamides; Vascular Surgical Procedures; Ventricular Function, Left | 2008 |
[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome].
Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Pneumonia, Bacterial; Retrospective Studies; Serine Proteinase Inhibitors; Severity of Illness Index; Sulfonamides; Systemic Inflammatory Response Syndrome | 2008 |
Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Caspase 7; Cell Survival; Endothelium; Extracellular Space; Glycine; Leukocyte Elastase; Male; Neurons; Neuroprotective Agents; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Wistar; Reperfusion; Sulfonamides; Time Factors | 2009 |
Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB.
Topics: Animals; Cell Line; Cytokines; Glycine; HMGB1 Protein; Leukocyte Elastase; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides | 2009 |
Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia.
Topics: Acetylcholine; Animals; Cardiotonic Agents; Coronary Circulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Glycine; In Vitro Techniques; Leukocyte Elastase; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Troponin T; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure | 2009 |
Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Glycine; Infusions, Intra-Arterial; Leukocyte Elastase; Motor Activity; Motor Neurons; Neuroprotective Agents; Paraplegia; Rabbits; Serine Proteinase Inhibitors; Spinal Cord Injuries; Spinal Cord Ischemia; Sulfonamides | 2009 |
Sivelestat treatment for acute respiratory distress syndrome in an infant.
Topics: Anti-Inflammatory Agents; C-Reactive Protein; Cardiopulmonary Resuscitation; Glycine; Humans; Hypoxia, Brain; Immunosuppressive Agents; Infant; Leukocyte Count; Leukocyte Elastase; Male; Oxygen; Positive-Pressure Respiration; Protein Kinase Inhibitors; Radiography; Respiratory Distress Syndrome; Sulfonamides | 2009 |
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Glycine; Leukocytes; Lipid Peroxidation; Liver; Male; Microcirculation; Models, Animal; Pancreatic Elastase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2009 |
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2010 |
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis | 2010 |
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.
Topics: Animals; Apoptosis; Bleomycin; Bronchoalveolar Lavage Fluid; Caspase 3; Caspase 9; Cell Line; Chemotaxis, Leukocyte; Cytokines; Epithelial Cells; Glycine; Humans; Hydroxyproline; Leukocyte Elastase; Lung; Male; Neutrophils; Poly(ADP-ribose) Polymerases; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 2009 |
The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
Topics: Acute Lung Injury; Adult; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dehydroascorbic Acid; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Female; Glycine; Humans; Male; Middle Aged; Oxidative Stress; Point-of-Care Systems; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2010 |
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
Topics: Animals; Chemokine CXCL1; DNA Primers; Glycine; Humans; Immunohistochemistry; Inflammation; Interleukin-6; Leukocyte Elastase; Liver; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Polymerase Chain Reaction; Proteinase Inhibitory Proteins, Secretory; Reperfusion Injury; RNA; Sulfonamides; Tumor Necrosis Factor-alpha | 2010 |
Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus.
Topics: Acute Lung Injury; Adult; Antiviral Agents; Female; Glycine; Hemorrhage; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung Diseases; Oseltamivir; Sulfonamides; Treatment Outcome | 2010 |
Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion.
Topics: Animals; Blood Platelets; Cytokines; Glycine; Liver; Liver Circulation; Liver Diseases; Male; Neutrophils; Platelet Adhesiveness; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2010 |
Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection.
Topics: Acute Disease; Aged; Antithrombin III; Aortic Aneurysm; Aortic Dissection; Blood Vessel Prosthesis Implantation; C-Reactive Protein; Female; Glycine; Humans; Infusions, Intravenous; International Normalized Ratio; Leukocyte Count; Leukocyte Elastase; Lung; Male; Middle Aged; Partial Thromboplastin Time; Platelet Count; Postoperative Hemorrhage; Prothrombin Time; Respiratory Function Tests; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome | 2010 |
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.
Topics: Animals; Coronary Circulation; Female; Glycine; Interleukin-6; Male; Myocardial Ischemia; Myocardial Stunning; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Swine | 2010 |
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Cephalosporins; Glycine; Hepatic Artery; Iloprost; Indomethacin; Insulin-Like Growth Factor I; Leukocyte Elastase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Peroxidase; Platelet Aggregation Inhibitors; Portal Vein; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides | 2010 |
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.
Topics: Acute Disease; Angiopoietin-1; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cells, Cultured; Glycine; Humans; Hypoxia-Ischemia, Brain; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Microvessels; Proteinase Inhibitory Proteins, Secretory; Sulfonamides | 2010 |
Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Gabexate; Glycine; Hydrochloric Acid; Leukocyte Count; Lung Injury; Male; Neutrophils; Protease Inhibitors; Proteinase Inhibitory Proteins, Secretory; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium; Sulfonamides | 2010 |
Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats.
Topics: Animals; Glycine; HSP70 Heat-Shock Proteins; Male; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Testis; Testosterone | 2011 |
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
Topics: Acute Lung Injury; Animals; Blotting, Western; Chemokines; Glycine; Interleukin-6; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Nephrectomy; Neutrophil Activation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Tumor Necrosis Factor-alpha | 2010 |
Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.
Topics: Cell Line; Cell Proliferation; Glycine; Humans; Ki-67 Antigen; Leukocyte Elastase; Organ Culture Techniques; Psoriasis; Sulfonamides; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Therapy, Combination; Fluoroquinolones; Glycine; Legionella pneumophila; Legionnaires' Disease; Leukocyte Elastase; Longevity; Lung; Male; Mice; Mice, Inbred Strains; Oxazines; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2010 |
Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Gastrointestinal Tract; Glycine; Interleukin-6; Intestinal Mucosa; Ischemia; Leukocyte Elastase; Lymphocyte Count; Lymphocyte Subsets; Male; Mice; Mice, Inbred ICR; Reperfusion; Sulfonamides; Survival Analysis | 2010 |
Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture.
Topics: Acute Lung Injury; Flow Cytometry; Glycine; Granulocytes; Humans; In Vitro Techniques; Interleukin-8; Lipopolysaccharides; Monocytes; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Tumor Necrosis Factor-alpha | 2010 |
A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Health Status; Health Surveys; Humans; Inflammation; Japan; Lung Diseases; Male; Middle Aged; Postoperative Complications; Risk Factors; Serine Proteinase Inhibitors; Stress, Psychological; Sulfonamides; Systemic Inflammatory Response Syndrome | 2010 |
Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes.
Topics: Animals; Cells, Cultured; Cytokines; Gene Expression Regulation, Enzymologic; Glycine; Hepatocytes; Male; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides | 2011 |
The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.
Topics: Animals; Chorioamnionitis; Cytokines; Dinoprostone; Disease Models, Animal; Female; Fetal Blood; Glycine; Lipopolysaccharides; Obstetric Labor, Premature; Pregnancy; Random Allocation; Serine Proteinase Inhibitors; Sheep; Sulfonamides; Uterine Contraction | 2011 |
Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.
Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Laryngopharyngeal Reflux; Male; Middle Aged; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Time Factors; Treatment Outcome | 2011 |
Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.
Topics: Aged; Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Hemodynamics; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Stomach; Sulfonamides; Vasoconstriction; Vasodilation; Vasodilator Agents | 2011 |
AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Dogs; Dose-Response Relationship, Drug; Emphysema; Female; Glycine; Guinea Pigs; Humans; Kinetics; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Oxadiazoles; Pneumonia; Protein Binding; Pyridones; Pyrimidinones; Rats; Serine Proteinase Inhibitors; Species Specificity; Substrate Specificity; Sulfonamides; Sulfones; Swine; Tobacco Smoke Pollution | 2011 |
Recent advancements of total aortic arch replacement.
Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Vessel Prosthesis Implantation; Body Temperature Regulation; Cardiopulmonary Bypass; Chi-Square Distribution; Emergency Treatment; Female; Glycine; Hospital Mortality; Humans; Male; Postoperative Complications; Retrospective Studies; Risk Factors; Serine Proteinase Inhibitors; Sternotomy; Sulfonamides; Survival Rate; Treatment Outcome | 2012 |
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Glycine; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Smad2 Protein; Smad3 Protein; Sulfonamides; Transforming Growth Factor beta1 | 2012 |
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
Topics: Acute Lung Injury; Aged; C-Reactive Protein; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Inflammation; Length of Stay; Male; Middle Aged; Oxygen; Perioperative Period; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sulfonamides; Survival Rate | 2012 |
Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
Topics: Acute Lung Injury; Administration, Inhalation; Albumins; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cell Count; Extravascular Lung Water; Female; Glycine; Injections, Intravenous; Leukocyte Count; Leukocyte Elastase; Oleic Acid; Ovalbumin; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Survival Analysis | 2012 |
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glycine; Humans; Leukocyte Elastase; Receptor, ErbB-2; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides; Transforming Growth Factor alpha; Trastuzumab | 2012 |
Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Embolism, Fat; Glycine; In Vitro Techniques; Inflammation Mediators; Leukocyte Elastase; Lung; Male; Neutrophil Activation; Neutrophils; Pulmonary Embolism; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate | 2012 |
Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9.
Topics: Acetylcysteine; Adult; Animals; Antigens, CD; Cell Line; CHO Cells; Cricetinae; Cricetulus; Female; Free Radical Scavengers; Glycine; Humans; Immune Evasion; Immunity, Innate; Lectins; Leukosialin; Male; Neutrophils; Phagocytosis; Pseudomonas aeruginosa; Pseudomonas Infections; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sialic Acid Binding Immunoglobulin-like Lectins; Sulfonamides | 2012 |
Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Glycine; Glycoproteins; Humans; Interferon-beta; Male; Mice; Mice, Inbred C57BL; Middle Aged; Myelin-Oligodendrocyte Glycoprotein; Neuromyelitis Optica; Pancreatic Elastase; Peptide Fragments; Serine Proteinase Inhibitors; Sulfonamides; Th1 Cells; Th17 Cells; Young Adult | 2012 |
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage; Collagen; Fibrosis; Glycine; Inflammation; Leukocyte Elastase; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Pulmonary Fibrosis; Serine Proteinase Inhibitors; Smad2 Protein; Sulfonamides; Time Factors; Transforming Growth Factor beta1 | 2012 |
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Antipyrine; Drug Combinations; Edaravone; Free Radical Scavengers; Glycine; Interleukin-6; Lipopolysaccharides; Male; Malondialdehyde; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Necrosis Factor-alpha | 2012 |
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
Topics: Glycine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Leukocyte Elastase; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Sulfonamides | 2012 |
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Constriction; Glycine; Intestines; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate | 2013 |
Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.
Topics: Adult; Amniotic Fluid; Female; Fetal Membranes, Premature Rupture; Glycine; Humans; Injections, Intravenous; Interleukin-6; Interleukin-8; Magnesium Sulfate; Obstetric Labor, Premature; Pregnancy; Ritodrine; Serine Proteinase Inhibitors; Sulfonamides; Tocolytic Agents; Young Adult | 2012 |
CXC receptor 1 and 2 and neutrophil elastase inhibitors alter radiation-induced lung disease in the mouse.
Topics: Animals; Female; Glycine; Male; Mice; Neutrophils; Proteinase Inhibitory Proteins, Secretory; Radiation Injuries, Experimental; Radiation Pneumonitis; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Sex Factors; Sulfonamides | 2013 |
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
Topics: Animals; Blast Injuries; Bronchoalveolar Lavage Fluid; Burns; Carbon Dioxide; Disease Models, Animal; Glycine; Interleukin-8; Leukocyte Elastase; Lung Injury; Male; Oxygen; Partial Pressure; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2013 |
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Lung; Lung Injury; Male; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides | 2012 |
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sepsis; Sulfonamides; Ventilator Weaning | 2012 |
Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats.
Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Dioxide; Combined Modality Therapy; Crush Syndrome; Drug Evaluation, Preclinical; Fluid Therapy; Glycine; HMGB1 Protein; Liver; Lung; Male; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhabdomyolysis; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Treatment Outcome | 2013 |
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses.
Topics: Allergens; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines; Cytokines; Female; Flow Cytometry; Glycine; Immunohistochemistry; Inflammation; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ovalbumin; Proteinase Inhibitory Proteins, Secretory; Receptor, PAR-2; Respiratory Hypersensitivity; Sulfonamides | 2013 |
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
Topics: Abnormalities, Radiation-Induced; Animals; Glycine; Humans; Inflammation; Leukocyte Elastase; Lung; Lung Injury; Mice; Radiation-Protective Agents; Sulfonamides | 2013 |
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Drug Administration Schedule; Drug Therapy, Combination; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Intraoperative Care; Male; Methylprednisolone; Middle Aged; Postoperative Care; Postoperative Complications; Respiratory Distress Syndrome; Respiratory Function Tests; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2013 |
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
Topics: Acute Lung Injury; Adult; Aged; Combined Modality Therapy; Drug Administration Schedule; Glycine; Humans; Infusions, Intravenous; Male; Middle Aged; Pneumonectomy; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Treatment Outcome | 2013 |
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Precursors; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate | 2013 |
Sivelestat attenuates myocardial reperfusion injury during brief low flow postischemic infusion.
Topics: Animals; Aorta; Cardiotonic Agents; Cattle; Coronary Circulation; Creatine Kinase; Electron Spin Resonance Spectroscopy; Endothelial Cells; Glycine; Heart Ventricles; In Vitro Techniques; Male; Models, Cardiovascular; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfonamides; Superoxides; Vasoconstriction; Ventricular Function, Left | 2013 |
Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model.
Topics: Amylases; Animals; Antioxidants; Ceruletide; Corticosterone; Disease Models, Animal; Glycine; Inflammation; Interleukin-1beta; Interleukin-4; Lipase; Male; Oxidative Stress; Pancreas; Pancreatitis, Acute Necrotizing; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Survival; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2013 |
[Neutrophil elastase inhibitor on proliferation and apoptosis of U937 cells].
Topics: Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Glycine; Humans; Leukocyte Elastase; Piperidines; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; U937 Cells | 2013 |
The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.
Topics: Animals; Cecum; Cell Division; Cell Line; Gastrointestinal Neoplasms; Glycine; Leukocyte Elastase; Ligation; Mice; Mice, Inbred C57BL; Peritonitis; Serine Proteinase Inhibitors; Sulfonamides | 2013 |
Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats.
Topics: Acute Lung Injury; Animals; Glycine; Histological Techniques; Injections, Intraperitoneal; Interleukin-6; Lung; Male; Neutrophil Activation; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Sulfonamides; Tumor Necrosis Factor-alpha | 2014 |
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
Topics: Animals; Cell Adhesion; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Immune System Diseases; Leukocyte Disorders; Liver Diseases; Male; Neutrophils; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome | 2014 |
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Glycine; Humans; Kinetics; Leukocyte Elastase; Mice, Inbred BALB C; Molecular Docking Simulation; Pentacyclic Triterpenes; Pneumonia; Proton Magnetic Resonance Spectroscopy; Saponins; Smoking; Sulfonamides; Triterpenes; Ursolic Acid | 2013 |
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
Topics: Amino Acid Sequence; Animals; Biomarkers, Tumor; Colorectal Neoplasms; Glycine; Humans; Leukocyte Elastase; Mice; Mice, Nude; Molecular Sequence Data; Molecular Targeted Therapy; Serine Proteinase Inhibitors; Sulfonamides; Xenograft Model Antitumor Assays | 2014 |
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Pulmonary Edema; Rats; Rats, Wistar; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Transcription Factor RelA | 2014 |
[Anesthetic management of posterior lumbar spinal fusion in a patient suspected of having acute exacerbation of chronic interstitial pneumonia].
Topics: Acute-Phase Reaction; Aged; Airway Management; Anesthesia; Chronic Disease; Disease Progression; Emergency Medical Services; Female; Glycine; Humans; Lumbar Vertebrae; Lung Diseases, Interstitial; Perioperative Care; Postoperative Complications; Respiration Disorders; Spinal Fusion; Spinal Stenosis; Sulfonamides | 2014 |
Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis.
Topics: Animals; Chemokines; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Glycine; Interleukin-17; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Peroxidase; Proteinase Inhibitory Proteins, Secretory; RNA, Messenger; Sulfonamides | 2014 |
Effect of additional preoperative administration of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass.
Topics: C-Reactive Protein; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Glycine; Heart Septal Defects, Ventricular; Humans; Infant; Inflammation; Leukocyte Count; Male; Neutrophils; Pancreatic Elastase; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome | 2014 |
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
Topics: Acute Disease; Amylases; Animals; Arterial Pressure; Bronchoalveolar Lavage Fluid; Glycine; Interleukin-6; Leukocyte Elastase; Lung; Lung Injury; Male; Oxygen; Pancreatitis; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Stilbenes; Sulfonamides | 2014 |
[Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury].
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Capillary Permeability; Dogs; Extravascular Lung Water; Glycine; Infusions, Intravenous; Interleukin-8; Male; Pulmonary Edema; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2014 |
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
Topics: Aged; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Glycine; Humans; Male; Middle Aged; Recombinant Proteins; Respiratory Distress Syndrome; Retrospective Studies; Solubility; Sulfonamides; Thrombomodulin | 2014 |
Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.
Topics: Animals; Animals, Newborn; Cell Movement; Elafin; Elastin; Female; Glycine; Leukocyte Elastase; Lung; Lung Injury; Macrophages; Maternal Exposure; Neutrophils; Oxygen; Peroxynitrous Acid; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8B; Sulfonamides; Triazoles; Vascular Remodeling | 2015 |
Elevation of pivaloylcarnitine by sivelestat sodium in two children.
Topics: Amino Acid Metabolism, Inborn Errors; Cardiomyopathies; Carnitine; Child, Preschool; Chromatography, Liquid; Female; Glycine; Humans; Hyperammonemia; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Muscular Diseases; Neonatal Screening; Serine Proteinase Inhibitors; Sulfonamides; Tandem Mass Spectrometry | 2015 |
Post-fertilization effect of bilateral primary testicular damage induced by unilateral cryptorchidism in the rat model.
Topics: Animals; Animals, Newborn; Antioxidants; Cryptorchidism; Embryonic Development; Female; Fertility; Glycine; Male; Rats; Rats, Wistar; Sulfonamides; Taurine; Testis | 2016 |
Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1.
Topics: Animals; Annexin A1; Apoptosis; Blotting, Western; Flow Cytometry; Glycine; Humans; Inflammation; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neutrophils; Protease Inhibitors; Secretory Leukocyte Peptidase Inhibitor; Sulfonamides | 2016 |
[Simultaneous determination of sivelestat and its metabolite XW-IMP-A in human plasma using HPLC-MS/MS].
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Glycine; Humans; Inosine Monophosphate; Reproducibility of Results; Sulfonamides; Tandem Mass Spectrometry | 2015 |
Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-8; Leukocyte Elastase; Lung; Rats; Rats, Sprague-Dawley; Sulfonamides; Systemic Inflammatory Response Syndrome | 2016 |
GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycine; Interleukin-1beta; Male; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Nuclear Proteins; Random Allocation; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Sulfonamides; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases | 2016 |
Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apolipoproteins E; Chemokine CCL2; Diet, High-Fat; Disease Models, Animal; Glycine; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Kupffer Cells; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Non-alcoholic Fatty Liver Disease; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha | 2015 |
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-6; Leukocyte Count; Leukocyte Elastase; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neutrophils; Sulfonamides; Survival Analysis; Tetracyclines; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factors | 2016 |
The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Glomerular Filtration Rate; Glycine; HMGB1 Protein; Injections, Intraperitoneal; Interleukin-1beta; Kaplan-Meier Estimate; Kidney; Leukocyte Elastase; Lipocalin-2; Male; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha | 2016 |
Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
Topics: Animals; Cecum; Dexamethasone; Disease Models, Animal; Glycine; Ligation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred ICR; Multiple Organ Failure; Phosphatidylcholines; Punctures; Reactive Oxygen Species; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides; Superoxide Dismutase | 2017 |
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
Topics: Acute Lung Injury; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glycine; Humans; Male; Prognosis; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome | 2017 |
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Female; Glycine; Intercellular Adhesion Molecule-1; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Lung; Mice; Mice, Inbred ICR; Neutropenia; Neutrophils; Pulmonary Edema; Sulfonamides; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2017 |
Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: propensity score analysis of a Japanese nationwide database.
Topics: Adult; Aged; Aged, 80 and over; Databases, Factual; Female; Glycine; Humans; Japan; Male; Middle Aged; Pneumonia; Propensity Score; Respiration, Artificial; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides | 2017 |
Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Female; Gefitinib; Glycine; Humans; Kaplan-Meier Estimate; Leukocyte Count; Leukocyte Elastase; Lung; Mice, Inbred C57BL; Naphthalenes; Neutrophils; Pneumonia; Quinazolines; Serine Proteinase Inhibitors; Sulfonamides; Weight Loss | 2017 |
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Topics: Animals; Chronic Pain; Glycine; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Osteoarthritis; Pre-Exposure Prophylaxis; Serine Proteinase Inhibitors; Sulfonamides | 2017 |
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
Topics: Analgesics; Animals; Cancer Pain; Chronic Pain; Cyclic S-Oxides; Disease Models, Animal; Female; Glycine; Hyperalgesia; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Pregabalin; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles | 2017 |
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study.
Topics: Bronchopulmonary Dysplasia; Drug Administration Schedule; Female; Glycine; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Male; Serine Proteinase Inhibitors; Sulfonamides | 2017 |
Prevention of Pulmonary Edema after Minimally Invasive Cardiac Surgery with Mini-Thoracotomy Using Neutrophil Elastase Inhibitor.
Topics: Adult; Aged; Cardiac Surgical Procedures; Female; Glycine; Humans; Infusions, Intravenous; Length of Stay; Leukocyte Elastase; Male; Middle Aged; One-Lung Ventilation; Pulmonary Edema; Retrospective Studies; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Thoracotomy; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2018 |
Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.
Topics: Animals; Cattle; Cysteine Proteases; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Glycine; HEK293 Cells; Humans; Leukocyte Elastase; Neutrophil Activation; Neutrophils; Serine Proteases; Sulfonamides; Swine | 2018 |
Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG- and IgA-producing cells.
Topics: Animals; B-Cell Activating Factor; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Glycine; Immunoglobulin A; Immunoglobulin G; Interleukin-10; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Neutrophils; Pancreatic Elastase; RNA, Messenger; Serine Proteinase Inhibitors; Spleen; Sulfonamides; Syndecan-1; Tumor Necrosis Factor Ligand Superfamily Member 13 | 2018 |
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Glycine; Humans; Immunity, Innate; Leukocyte Elastase; Male; Mice, Inbred BALB C; NF-kappa B; Pneumonia, Pneumococcal; Serine Proteinase Inhibitors; Streptococcus pneumoniae; Sulfonamides; THP-1 Cells; Toll-Like Receptors | 2018 |
Enhanced pause correlates with airway neutrophils and airway-epithelial injury in asthmatic mice treated with dexamethasone.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Eosinophils; Female; Glycine; Inflammation; Lymphocytes; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyroglyphidae; Respiratory Mucosa; Respiratory System; Sulfonamides | 2019 |
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Cicatrix; Cytokines; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Glycine; Humans; Laminin; Leukocyte Elastase; Nerve Tissue Proteins; Nociceptin; Occludin; Opioid Peptides; Rats; Rats, Sprague-Dawley; Recovery of Function; Serine Proteinase Inhibitors; Spinal Cord Injuries; Sulfonamides; Transforming Growth Factor beta1; Zonula Occludens-1 Protein | 2018 |
ONO-5046 suppresses reactive oxidative species-associated formation of neutrophil extracellular traps.
Topics: Adult; Cells, Cultured; Extracellular Traps; Glycine; Humans; Inflammation; Lipopolysaccharides; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sulfonamides | 2018 |
Rolipram plus Sivelestat inhibits bone marrow-derived leukocytic lung recruitment after cardiopulmonary bypass in a primate model.
Topics: Animals; Bone Marrow Cells; Cardiopulmonary Bypass; Chemotaxis, Leukocyte; Disease Models, Animal; Glycine; Lung; Macaca fascicularis; Male; Neutrophils; Phosphodiesterase 4 Inhibitors; Rolipram; Serine Proteinase Inhibitors; Sulfonamides | 2019 |
Prophylactic sivelestat for esophagectomy and in-hospital mortality: a propensity score-matched analysis of claims database.
Topics: Aged; Databases, Factual; Esophagectomy; Female; Glycine; Hospitals; Humans; Japan; Male; Middle Aged; Postoperative Complications; Propensity Score; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides | 2019 |
Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Glycine; Humans; Kelch-Like ECH-Associated Protein 1; Leukocyte Elastase; Male; NF-E2-Related Factor 2; Obesity; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides | 2019 |
Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.
Topics: Aggregatibacter actinomycetemcomitans; Cell Death; Cell Line; Epithelial Cells; Exotoxins; Fibroblasts; Gingiva; Glycine; Humans; Leukocyte Elastase; Neutrophils; Periodontitis; Sulfonamides; Virulence Factors | 2019 |
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
Topics: Animals; Endothelium; Endotoxemia; Glycine; Glycocalyx; Leukocyte Elastase; Lipopolysaccharides; Lung; Mice; Mice, Knockout; Sulfonamides | 2019 |
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cytokines; Disease Models, Animal; Glycine; Granulins; Leukocyte Elastase; Male; Microglia; Progranulins; Rats; Sulfonamides; Up-Regulation | 2019 |
Neutrophil Elastase Inhibition Ameliorates Endotoxin-induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx.
Topics: Animals; Endotoxemia; Endotoxins; Glycine; Glycocalyx; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-6; Leukocyte Elastase; Male; Mice; Mice, Knockout; Microscopy, Electron; Sulfonamides; Troponin I | 2020 |
Neutrophil Elastase Inhibitor Sivelestat Attenuates Myocardial Injury after Cardioplegic Arrest in Rat Hearts.
Topics: Animals; Disease Models, Animal; Glycine; Heart Arrest, Induced; Isolated Heart Preparation; Leukocyte Elastase; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Troponin T; Ventricular Function, Left; Ventricular Pressure | 2020 |
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Free Radical Scavengers; Glycine; Inflammation; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides | 2020 |
Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis.
Topics: Actins; Animals; Bleomycin; Cells, Cultured; Chemokine CXCL1; Chemotaxis; Collagen; Glycine; Humans; Male; Mice; Mice, Inbred C57BL; Neutrophils; Particulate Matter; Pulmonary Fibrosis; Smad Proteins; Sulfonamides | 2019 |
Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Coagulation; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Internal; Cell-Derived Microparticles; Extracellular Traps; Female; Fibrin; Glycine; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Neutrophils; Phosphatidylserines; Platelet Activation; Stroke; Sulfonamides; Thrombin | 2020 |
Engineering synthetic breath biomarkers for respiratory disease.
Topics: alpha 1-Antitrypsin Deficiency; Animals; Biomarkers; Breath Tests; Computer Simulation; Dose-Response Relationship, Drug; Drug Carriers; Female; Glycine; Humans; Leukocyte Elastase; Lung Diseases; Mass Spectrometry; Mice, Inbred Strains; Mice, Knockout; Nanostructures; Polyethylene Glycols; Pseudomonas Infections; Sulfonamides; Volatile Organic Compounds | 2020 |
Tissue damage from neutrophil-induced oxidative stress in COVID-19.
Topics: Acetylcysteine; Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokines; Drug Therapy, Combination; Extracellular Traps; Gene Expression Regulation; Glycine; Host-Pathogen Interactions; Humans; Immunity, Innate; Lung; Lymphocytes; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pandemics; Pneumonia, Viral; Proteinase Inhibitory Proteins, Secretory; Reactive Oxygen Species; SARS-CoV-2; Severity of Illness Index; Sulfonamides; Superoxide Dismutase | 2020 |
Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
Topics: Antiviral Agents; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; Esters; Gabexate; Glycine; Guanidines; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Pandemics; Pneumonia, Viral; Protein Structure, Tertiary; SARS-CoV-2; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfonamides | 2020 |
Sivelestat-loaded nanostructured lipid carriers modulate oxidative and inflammatory stress in human dental pulp and mesenchymal stem cells subjected to oxygen-glucose deprivation.
Topics: Dental Pulp; Drug Carriers; Glucose; Glycine; Humans; Lipids; Mesenchymal Stem Cells; Nanostructures; Oxidative Stress; Oxygen; Sulfonamides | 2021 |
Possible involvement of progranulin in the protective effect of elastase inhibitor on cerebral ischemic injuries of neuronal and glial cells.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cytokines; Glycine; Male; Neuroglia; Neurons; Pancreatic Elastase; Progranulins; Rats; Rats, Wistar; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides | 2021 |
Tissue neutrophil elastase contributes to extracorporeal shock wave lithotripsy-induced kidney damage and the neutrophil elastase inhibitor, sivelestat, attenuates kidney damage with gratifying immunohistopathological and biochemical findings: an experime
Topics: Animals; Glycine; Kidney; Kidney Calculi; Leukocyte Elastase; Lithotripsy; Proteinase Inhibitory Proteins, Secretory; Rats; Sulfonamides | 2022 |
Efficacy, safety, and pharmacoeconomics of sivelestat sodium in the treatment of septic acute respiratory distress syndrome: a retrospective cohort study.
Topics: Economics, Pharmaceutical; Glycine; Humans; Respiratory Distress Syndrome; Retrospective Studies; Sodium; Sulfonamides | 2021 |
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
Topics: Animals; Gastrointestinal Microbiome; Glycine; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides | 2022 |
Sivelestat's effect on Candida albicans water-soluble fraction-induced vasculitis.
Topics: Animals; Candida albicans; Glycine; Humans; Intercellular Adhesion Molecule-1; Mice; Mucocutaneous Lymph Node Syndrome; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha; Vasculitis | 2022 |
[Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats].
Topics: Acute Lung Injury; Animals; Drugs, Chinese Herbal; Glycine; Interleukin-6; Lipopolysaccharides; Lung; Male; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sulfonamides | 2022 |