Page last updated: 2024-08-26

sivelestat and glycine

sivelestat has been researched along with glycine in 310 studies

Research

Studies (310)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's67 (21.61)18.2507
2000's112 (36.13)29.6817
2010's115 (37.10)24.3611
2020's16 (5.16)2.80

Authors

AuthorsStudies
Hecker, M; Kaw, S; Southan, GJ; Vane, JR; Warner, TD1
Imaki, K; Kawabata, K; Miyamoto, T; Sugitani, M; Suzuki, M; Toda, M1
Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M1
Aoshiba, K; Kakuta, Y; Konno, K; Nagai, A; Ozawa, Y; Yasui, S1
Fujimoto, K; Kobayashi, T; Kubo, K; Matsuzawa, Y; Okada, K; Shinozaki, S; Sugane, K1
Isohama, Y; Kai, H; Miyata, T; Takahama, K; Yoshitake, K1
Guo, L; Ikei, S; Ogawa, M; Sugita, H; Yamaguchi, Y1
Kakimoto, K; Matsukawa, A; Nakamura, H; Yoshinaga, M1
Hayano, T; Honda, T; Kobayashi, T; Koizumi, T; Kubo, K; Sakai, A; Sekiguchi, M1
Aishita, H; Nakagawa, T; Sawada, M; Shintani, T; Takamoto, M1
Homma, T; Kobayashi, T; Koyama, S; Nakagawa, S; Yoshimura, K1
Maeda, T; Matsukawa, A; Ohkawara, S; Takagi, K; Yoshinaga, M1
Iwamura, H; Moore, AR; Willoughby, DA1
Hasegawa, N; Ishizaka, A; Kanazawa, M; Nakagawa, N; Nakamura, H; Obata, T; Sakamaki, F; Sato, K; Sayama, K; Tasaka, S; Terashima, T; Urano, T; Waki, Y1
Johno, M; Murakami, K; Nakagaki, T; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M1
Akizuki, E; Goto, M; Ichiguchi, O; Miyanari, N; Mori, K; Ogawa, M; Wang, FS; Yamada, S; Yamaguchi, Y1
Ichikawa, H; Iino, Y; Kamoshita, N; Kobayashi, J; Morishita, Y; Ohwada, S; Ohya, T; Takahashi, T; Tomizawa, N1
Ichikawa, H; Iino, Y; Izumi, M; Kamoshita, N; Kobayashi, J; Morishita, Y; Nakamura, S; Ogawa, T; Ohwada, S; Ohya, T; Takahashi, T; Tomizawa, N1
Binder, BR; Kushimoto, S; Okabe, H; Okajima, K1
Harada, N; Kushimoto, S; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M1
Amino, T; Imaki, K; Kawamura, M; Kobayashi, K; Mohri, T; Nagao, Y; Nakai, H; Nakayama, Y; Okada, T; Sakai, Y1
Akizuki, E; Goto, M; Ichiguchi, O; Matsumura, F; Miyanari, N; Mori, K; Ogawa, M; Yamada, S; Yamaguchi, Y1
Harada, N; Johno, M; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M1
Furuno, T; Hara, N; Hidaka, K; Mitsuyama, T; Tanaka, T1
Harada, N; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Tanaka, K; Uchiba, M1
Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M; Takao, Y1
Higashi, Y; Kato, A; Murakami, T; Sato, M; Watanabe, F; Yata, N1
Kitamura, S2
Kitamura, S; Kobayashi, J1
Hiyama, K; Ishioka, S; Maeda, A; Taooka, Y; Yamakido, M1
Kondo, M; Nagai, A; Takeda, Y; Tamaoki, J; Yamawaki, I1
Hattori, S; Kaneko, K; Kudoh, I; Ohara, M; Okumura, F; Wiener-Kronish, J; Yamada, H1
Harada, N; Liu, W; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M1
Inada, M; Ogawa, M; Yamashita, J1
Ishioka, S1
Ishihara, H; Kudoh, A; Kudoh, E; Matsuki, A1
An, XY; Kamohara, H; Mita, S; Ogawa, M; Sakamoto, K1
Matsumura, F; Ogawa, M; Yamaguchi, Y1
Inoue, T; Kyi, M; Miyake, S; Miyazaki, Y; Sawada, M; Yoshizawa, Y1
Isohama, Y; Kai, H; Kido, T; Miyata, T; Tai, S; Takahama, K1
Matsukawa, A; Matsuura, K; Okamura, H; Tanaka, N; Ujioka, T; Yoshinaga, M1
Haga, Y; Ogawa, M1
Fujimura, M; Matsuda, T; Matsushima, K; Myou, S; Tachibana, H; Tsujiura, M; Xiu, Q1
Arakawa, M; Gejyo, F; Imai, N; Kazama, JJ; Kimura, H; Kuroda, T; Suzuki, S1
Higashi, Y; Higashikawa, F; Murakami, T; Okochi, A; Sato, M; Takano, M; Yata, N1
Akizuki, E; Horiuchi, T; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Wang, FS; Yamada, S; Yamaguchi, Y1
Abe, T; Handa, M; Ohya, N; Sakuma, T; Takahashi, K; Usuda, K1
Fujita, T; Mori, H; Nishiyama, K; Shichino, Y; Shimizu, K; Shinomiya, K; Suzuki, Y; Ueda, H; Yamaguchi, K; Yanagi, H; Yonezawa, H1
Fujita, T; Mori, H; Nishibata, K; Nishiyama, K; Oida, H; Shichino, Y; Shimizu, K; Shinomiya, K; Suzuki, Y; Tanaka, M; Ueda, H; Yamaguchi, K; Yanagi, H; Yonezawa, H1
Fujita, T; Mori, H; Nishibata, K; Nishiyama, K; Oida, H; Shichino, Y; Shimizu, K; Suzuki, Y; Tanaka, M; Yamaguchi, K; Yanagi, H; Yonezawa, H1
Aze, Y; Fujita, T; Mori, H; Nanba, T; Nishibata, K; Nishiyama, K; Oida, H; Oku, H; Shichino, Y; Shimizu, K; Shinomiya, K; Suzuki, Y; Tanaka, M; Ueda, H; Yamaguchi, K; Yanagizawa, Y; Yonezawa, H1
Fujita, T; Ide, M; Ishii, T; Katsumata, T; Numata, H; Okamoto, M; Suzuki, H; Tamura, K1
Aze, Y; Chihara, N; Fujita, T; Kitagawa, T; Nakagawa, Y; Nishimura, T; Ozeki, Y; Sakamoto, T; Shinomiya, K; Shirakawa, R; Sugai, S1
Aze, Y; Chihara, N; Fujita, T; Ikeda, Y; Nakagawa, Y; Nishimura, T; Ozeki, Y; Sakamoto, T; Shinomiya, K; Shirakawa, R; Sugai, S1
Chihara, N; Fujita, T; Ikeda, Y; Itagaki, I; Nakagawa, Y; Nishimura, T; Ozeki, Y; Sakai, M; Sakamoto, T; Shinomiya, K; Shirakawa, R; Sugai, S1
Harada, N; Irie, T; Isobe, H; Liu, W; Murakami, K; Okajima, K1
Kawashima, Y; Morishita, Y; Ohwada, S; Ohya, T; Takeyoshi, I; Tomizawa, N1
Imamura, M; Mikami, Y; Takahashi, H; Yamauchi, H1
Aoshiba, K; Kondo, M; Nagai, A; Nakata, J; Tagaya, E; Tamaoki, J; Yamawaki, I1
Adachi, M; Kawashima, Y; Morishita, Y; Ogawa, T; Ohwada, S; Ohya, T; Takeyoshi, I; Tomizawa, N1
Nishizaki, T; Soejima, Y; Sugimachi, K; Uchiyama, H; Yanaga, K; Yoshizumi, T1
Chen, HM; Chen, JC; Chen, MF; Chi, CP; Chi, TY; Fan, LL; Hwang, TL; Shyr, MH1
Ishihara, K; Liang, J; Matsuda, T; Matsumura, F; Mori, K; Ogawa, M; Ohshiro, H; Okabe, K; Yamaguchi, Y1
Aizawa, H; Hara, N; Inoue, H; Koto, H; Matsumoto, K; Nakano, H1
Ooshima, H; Usui, A; Watanabe, T; Yamazaki, T; Yasuura, K1
Ikeda, Y; Kamanaka, Y; Kondo, K; Shimakura, A; Suzuki, Y; Umemura, K1
Euzger, HS; Flower, RJ; Goulding, NJ; Perretti, M1
Aizawa, H; Hara, N; Hirose, T; Koto, H; Matsumoto, K; Miyazaki, H; Nakano, H; Nishima, S; Nogami, H1
Aze, Y; Hagio, T; Kawabata, K; Matsumoto, S; Nakao, S; Ohno, H; Orita, S1
Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ1
Fujimoto, J; Fukushima, J; Kudoh, I; Miyazaki, H; Ohara, M; Okumura, F; Tazawa, T; Yamada, H1
Hanaoka, M; Kaneki, T; Koizumi, T; Kubo, K; Yamamoto, H1
Kawamura, Y; Nakatani, K; Sekine, I; Takeshita, S; Tsujimoto, H1
Fukumoto, Y; Moriyama, Y; Nakamura, K; Sakasegawa, K; Sakata, R; Toda, R; Ueno, M; Yamamoto, H; Yotsumoto, G1
Hagio, T; Kawabata, K; Matsumoto, S; Matsuoka, H; Nakao, S; Ohno, H1
Muraguchi, M; Murata, K; Nishisho, T; Ohmoto, Y; Ohsaki, H; Shiba, K; Takeda, E; Taketani, Y; Tonai, T1
Ishibashi, M; Ishii, H; Kuraki, T; Nishida, T; Takayama, M; Yoshida, M1
Ichikawa, H; Naito, Y; Nakamura, Y; Ochiai, J; Sugimoto, N; Yoshida, N; Yoshikawa, T1
Kawabata, K; Matsuoka, S; Repine, JE; Zeiher, BG1
Fujita, S; Hamanaka, N; Matsuoka, S; Nakai, H; Nakayama, Y; Odagaki, Y; Toda, M1
Ishii, K; Ito, Y; Kakita, A; Katagiri, H; Majima, M; Matsumoto, Y1
Doi, K; Horiuchi, T; Kimura, N; Tabo, T; Tanaka, K; Uchinami, M; Yokomachi, J; Yoshida, M1
Hayashi, N; Kato, S; Kondo, K; Ogawa, M; Tanaka, E; Yamashita, J1
Ishikawa, N; Kawaguchi, M; Oda, M; Tsunezuka, Y; Watanabe, G1
Hagio, T; Kawabata, K; Matsuoka, S1
Miyate, Y; Sato, K; Segawa, Y; Soma, J; Suzuki, M1
Hiwasa, T; Ikeda, K; Iwamoto, I; Nakajima, H; Saito, Y; Suzuki, K; Tamachi, T1
Abiru, T; Hagio, T; Kawabata, K; Matsumoto, S; Nakao, S; Ohno, H1
Bellomo, R; Naka, T; Uchino, S; Wan, L1
Harada, N; Mori, M; Okajima, K; Uchiba, M1
Artigas, A; Bernard, G; Dmitrienko, A; Jackson, K; Thompson, BT; Vincent, JL; Zeiher, BG1
Goto, F; Hinohara, H; Ieta, K; Kadoi, Y; Kosaka, T; Kunimoto, F; Saito, S1
Abiru, T; Aikawa, N; Hamada, C; Hirasawa, H; Ishizaka, A; Kubota, T; Matsuoka, S; Ogawa, M; Taenaka, N; Tamakuma, S1
Sugahara, K; Takara, I; Tokumine, J; Tomiyama, H1
Arinobu, Y; Himeji, D; Kikuchi, I; Kojima, T; Oguma, A; Ueda, A1
Kotake, Y; Matsumoto, M; Morisaki, H; Takeda, J; Yamamoto, M1
Abiru, T; Aikawa, N; Fujishima, S; Kobayashi, M; Matsuoka, S1
Hagio, T; Kawabata, K; Matsumoto, S; Matsuoka, S; Nakao, S1
Hiramatsu, Y; Homma, S; Matsuzaki, K; Sakakibara, Y; Sato, S; Shigeta, O1
Abe, M; Imai, K; Inagaki, N; Ishikawa, M; Kadoyama, T; Kurokawa, J; Nakagawa, T; Soga, Y; Suzuki, T; Takeda, M1
Akimau, P; Inoue, Y; Nishino, M; Seiyama, A; Shimazu, T; Sugimoto, H; Tanaka, H; Ukai, I1
Hinohara, H; Kadoi, Y; Kunimoto, F; Kuwano, H; Ogata, K; Yamaki, E1
Andoh, K; Hoshi, K; Kaise, A; Kato, M; Kurosawa, S; Satoh, D1
Endo, K; Hayashi, K; Kimura, Y; Mitsui, M; Shimoyama, M; Takano, K; Tsukahara, A1
Fujimoto, K; Jian, MY; Koizumi, T; Kubo, K; Tsushima, K1
Imabayashi, T; Kakihana, Y; Kanmura, Y; Matsunaga, A; Okayama, N; Omae, T; Setoguchi, D1
Takayama, N; Uchida, K1
Chida, K; Enomoto, N; Imokawa, S; Nagayama, M; Sano, T; Suda, T; Todate, A; Uchiyama, H; Yasuda, K1
Abe, K; Hiroshi, T; Matsuda, H; Matsumiya, G; Sakurai, M; Sawa, Y; Yamauchi, T1
Arroliga, AC; Diaz Guzman Zavala, E; Santacruz, JF1
Fujino, Y; Hata, H; Iwai, S; Matsuda, H; Matsumiya, G; Nishimura, M; Ono, M; Ryugo, M; Sawa, Y; Takano, H; Yamauchi, T1
Fujino, Y; Fujita, Y; Maeda, Y; Mashimo, T; Nishimura, M; Uchiyama, A1
Fujita, K; Hosotsubo, H; Inoue, Y; Ogura, H; Shimazu, T; Sugimoto, H; Tanaka, H; Ukai, I1
Chinen, H; Hibi, T; Hisamatsu, T; Inoue, N; Iwao, Y; Kamada, N; Matsuoka, K; Morohoshi, Y; Ogata, H; Okamoto, S; Sato, T; Takaishi, H1
Hashimoto, S; Shime, N1
Fukunaga, M; Iba, T; Kidokoro, A; Sugimotoa, K; Takuhiro, K; Yoshikawa, S1
Du, GH; Gao, F1
Mikawa, K; Misumi, T; Morikawa, O; Nishina, K; Obara, H; Tanaka, T1
Kito, K; Minami, T1
Hihara, J; Konishi, K; Mizuiri, H; Suzuki, T; Tanabe, K; Taomoto, J; Ukon, K; Wada, Y; Yoshida, K1
Akaike, H; Kawasaki, K; Miyauchi, A; Ouchi, K1
Amano, J; Fukui, D; Furusawa, T; Sakaguchi, M; Seto, T; Terasaki, T; Tsukioka, K; Wada, Y1
Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Takemoto, Y; Tanaka, T; Tsuchida, K; Yoshimura, R1
Furuhashi, T; Ishihara, K; Kihara, S; Mori, K; Ogawa, M; Uchino, S; Yamada, S; Yamaguchi, Y1
Dobashi, K; Hisada, T; Ishizuka, T; Mori, M; Shimizu, Y; Utsugi, M1
Katashima, S; Kikuchi, T; Kugimiya, T1
Ando, M; Ashihara, Y; Fukami, T; Hiroshige, S; Kumamoto, T; Miyazaki, E; Noguchi, T; Ohishi, K; Okubo, T; Sugisaki, K; Tsuda, T; Ueo, M; Yoshitake, S1
Hamai, Y; Hihara, J; Mizuiri, H; Oeda, M; Sanada, Y; Shigematsu, H; Suzuki, T; Tanabe, K; Tsutani, Y; Ukon, K; Wada, Y; Yoshida, K1
Nakajima, H; Nakajima, S; Sawaguchi, H1
Fukuda, I; Kondo, N; Suzuki, Y; Wakayama, F1
Jessen, ME1
Akagi, R; Inoue, K; Maeshima, K; Morimatsu, H; Morita, K; Omori, E; Shimizu, H; Takahashi, T; Takeuchi, M; Toda, Y1
Kaji, A; Rinka, H; Yoshida, T1
Kwon, AH; Qiu, Z1
Kondo, T; Niikawa, H; Oishi, H; Sugawara, T; Suzuki, S; Tabata, T1
Fukuda, Y; Hirakata, Y; Izumikawa, K; Kamhira, S; Kohno, S; Miyazaki, Y; Seki, M; Tsukamoto, K; Yamada, Y; Yanagihara, K1
Akamoto, S; Izuishi, K; Okano, K; Sano, T; Suzuki, Y; Usuki, H; Wakabayashi, H; Yachida, S1
Dangerfield, J; Nourshargh, S; Voisin, MB; Wang, S; Young, RE1
Funakoshi, Y; Ishizaka, A; Katori, N; Kawabata, K; Kotake, Y; Morisaki, H; Nakamura, N; Suzuki, T; Takeda, J; Yajima, S; Yamada, S1
Hato, F; Kato, N; Kato, T; Kitagawa, S; Kodama, T; Yukioka, H1
Hida, N; Horiuchi, N; Kunikane, H; Naoki, K; Narita, Y; Okamoto, H; Watanabe, K1
Kobayashi, K; Kotani, Y; Nishimura, Y; Nishiuma, T; Sakashita, A; Takenaka, K; Yokoyama, M1
Kozawa, S; Miyazawa, N; Nakamura, M; Ogura, T; Tagawa, A; Takahashi, H; Watanuki, Y1
Hanada, N; Hori, K; Kusano, S; Momi, H1
Date, H; Kotani, K; Mori, H; Nagahiro, I; Nakanishi, H; Osaragi, T; Sano, Y; Shimizu, N1
Ai, S; Cheng, XW; Iguchi, A; Inoue, A; Kuzuya, M; Murohara, T; Nakamura, K; Okumura, K1
Funakoshi, Y; Hashimoto, S; Ishizaka, A; Kitagawa, Y; Kitajima, M; Maruyama, I; Miyasho, T; Okamoto, M; Ozawa, S; Saikawa, Y; Suda, K; Tasaka, S; Ueda, M; Yamada, S; Yokota, H1
Furuya, H; Morioka, M; Morooka, T; Nomura, Y1
Aoki, H; Endo, S; Inoue, Y; Kojika, M; Nakadate, T; Sato, N; Suzuki, Y; Yaegashi, Y; Yamada, Y; Yoshida, Y1
Inomata, T; Narabayashi, I; Shimbo, T; Sonobe, H; Takahashi, M; Tatsumi, T; Uesugi, Y1
Kono, T; Okada, S; Saito, M1
Fujita, T; Kumasaka, R; Murakami, R; Nakamura, N; Okumura, K; Osawa, H; Shimada, M; Yamabe, H1
Hara, S; Kubota, M; Kuno, M; Nemoto, K; Ninomiya, N; Yamamoto, Y1
Iwasaki, Y; Kubota, K; Okada, T; Sawada, T; Shimoda, M1
Iwasaki, T; Kimura, H; Kitada, S; Maekura, R; Mori, M; Naka, N; Nakagawa, M; Nakazawa, Y; Namba, Y; Niinaka, M; Okada, T; Yano, Y; Yokota, S1
Amaya, F; Funakoshi, Y; Hashimoto, S; Ishizaka, A; Kawabata, K; Kimura, A; Okayama, Y; Shime, N1
Harada, H; Iwasaki, H; Kunisawa, T; Kurosawa, A; Nagashima, M; Takahashi, K; Takahata, O1
Ehara, N; Fukushima, K; Izumikawa, K; Kakeya, H; Kohno, S; Saito, A; Seki, M; Yamamoto, Y; Yanagihara, K1
Guo, F; Kishi, H; Kobayashi, S; Maeda, Y; Matsuo, S; Mitsumizo, S; Nakashima, M1
Kapoor, S1
Kunihara, T; Matsui, Y; Matsuzaki, K; Murashita, T; Shiiya, N; Shingu, Y1
Hagiwara, S; Iwasaka, H; Noguchi, T; Togo, K1
Chida, K; Fujisawa, T; Harada, M; Imokawa, S; Mori, K; Sagisaka, S; Sano, T; Suda, T; Uchiyama, H; Ukita, T; Yasuda, K1
Ando, M; Murai, T; Takahashi, Y1
Hiroshima, K; Iyoda, A; Moriya, Y; Shibuya, K; Yoshino, I1
Dardik, A; Kainuma, M; Kondo, Y; Muto, A; Nishibe, T; Ohara, Y; Takeda, K1
Asano, M; Matsumori, M; Morimoto, K; Morimoto, N; Morimoto, Y; Okada, K; Okita, Y; Takahashi, H1
Hagio, T; Hasegawa, N; Hashimoto, S; Ishizaka, A; Kawabata, K; Kishikawa, K; Tasaka, S1
Hatori, F; Shimizu, A; Takagi, T; Toyama, S1
Izumikawa, K; Kakeya, H; Kohno, S; Mukae, H; Nakamura, S; Seki, M; Tashiro, T; Yamamoto, Y; Yanagihara, K1
Gondo, T; Hirata, T; Ishida, K; Matayoshi, H; Matsumoto, M; Mizukami, Y; Sakabe, T; Yamashita, S1
Hagiwara, S; Hasegawa, A; Hidaka, S; Iwasaka, H; Noguchi, T1
Bessho, R; Fujii, M; Kambe, M; Ochi, M; Shimizu, K1
Goto, M; Higashi, A; Iguro, Y; Iwamoto, S; Sakata, R; Ueno, T1
Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Matsumoto, S; Noguchi, T; Shingu, C1
Abe, T; Akita, T; Oshima, H; Ueda, Y; Usui, A1
Fukunaga, K; Kondo, T; Matsuo, R; Murata, S; Nakano, Y; Ohkohchi, N1
Gando, S; Hayakawa, M; Hoshino, H; Katabami, K; Sawamura, A; Sugano, M; Wada, T1
Fujimura, T; Funaki, H; Fushida, S; Inaba, H; Kawahara, Y; Kayahara, M; Nakagawara, H; Ninomiya, I; Oyama, K; Tajima, H; Takamura, H1
Fukunaga, K; Funakoshi, Y; Hagiwara, T; Hashimoto, S; Ishizaka, A; Kawasako, K; Kitagawa, Y; Maruyama, I; Miyasho, T; Okamoto, M; Saikawa, Y; Suda, K; Suganuma, K; Takeuchi, H; Wada, N; Yamada, S; Yokota, H1
Kang, CM; Kim, YK; Moon, HS; Park, SH; Rhee, CK; Song, JS; Yoon, HK1
Goto, K; Hagiwara, S; Hidaka, S; Iwasaka, H; Koga, H; Matsumoto, S; Noguchi, T; Shingu, C; Yokoi, I1
Busuttil, RW; Freitas, MC; Kupiec-Weglinski, JW; Uchida, Y; Zhao, D1
Kobayashi, N; Koizumi, T; Kubo, K; Tsushima, K; Urushihata, K; Ushiki, A; Yokoyama, T1
Fukunaga, K; Kondo, T; Murata, S; Nakano, Y; Oda, T; Ohkohchi, N; Pak, S; Sasaki, R1
Bessho, R; Fujii, M; Miyagi, Y; Nitta, T; Ochi, M; Shimizu, K1
Fujita, K; Hata, M; Minami, K; Niino, T; Osaka, S; Sezai, A; Shimura, K; Unosawa, S; Yoshitake, I1
Akiyama, D; Cho, S; Hara, T; Maekawa, T; Sumikawa, K; Yoshitomi, O1
Harada, N; Kawai, M; Okajima, K; Takeyama, H1
Hayashi, S; Ikegame, Y; Iwama, T; Nakashima, S; Yamashita, K; Yoshimura, S1
Koizumi, T; Kubo, K; Tsushima, K; Yoshikawa, S1
Dimitriadis, F; Kinoshita, Y; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Shomori, K; Tsounapi, P1
Kaido, T; Uemoto, S1
Dohi, M; Doi, K; Fujita, T; Imamura, M; Ishii, T; Noiri, E; Okamoto, K; Yamamoto, K1
Hao, F; Yan, H; Yang, X; Ye, Q; Zhai, Z; Zhong, B1
Araki, N; Izumikawa, K; Kakeya, H; Kamihira, S; Kohno, S; Morinaga, Y; Seki, M; Yamada, K; Yamada, Y; Yamamoto, Y; Yanagihara, K1
Fukatsu, K; Maeshima, Y; Omata, J; Saitoh, D; Tanabe, K; Yasuhara, H1
Endo, S; Inada, K; Shibata, S; Shioya, N; Takahashi, G1
Harada, N; Harimoto, N; Kakeji, Y; Koga, T; Maehara, Y; Miyazaki, M; Morita, M; Nagata, S; Oki, E; Saeki, H1
Doi, A; Gremillion, DH; Igarashi, W; Iwata, K; Oba, Y; Ohji, G; Oka, H; Shimada, T; Takimoto, K1
Araki, Y; Kaibori, M; Kwon, AH; Matsumiya, M; Matsuura, T; Nishizawa, M; Okumura, T1
Masaoka, N; Nakajima, Y; Watanabe, M1
Iwahashi, M; Naka, T; Nakamori, M; Nakamura, M; Ojima, T; Yamaue, H1
Aikawa, N; Endo, S; Hirasawa, H; Ikeda, T; Ishizaka, A; Kawasaki, Y; Shimazaki, S; Shinozaki, M; Sugimoto, H; Taenaka, N; Yamamoto, Y1
Akiyama, H; Endo, I; Kosaka, T; Kunisaki, C; Makino, H; Morita, S1
Inada, E; Iwanuma, Y; Kajiyama, Y; Kugimiya, T; Kumakura, S; Nagaoka, I; Sugasawa, Y; Takeuchi, K; Tsurumaru, M; Yamaguchi, K1
Fujishima, S; Hayashida, K; Hori, S; Kitano, M; Orita, T; Sasao, K; Toyoda, Y1
Costa, E; Guedes, RC; Lucas, SD; Moreira, R1
Amemori, H; Maeda, Y; Nakashima, M; Torikai, A1
Churg, A; Ekholm, K; Falk-Håkansson, H; Gränse, M; Jungar, C; Kozma, V; Lal, H; Lindahl, M; Ottosson, T; Sanfridson, A; Stevens, T; Wright, JL1
Maeta, H; Miyasaka, S; Morimoto, K; Nishimura, K; Taniguchi, I1
Inoue, T; Kano, H; Okada, K; Okita, Y; Omura, A; Sakamoto, T; Tanaka, A1
Fujino, N; He, M; Kubo, H; Ota, C; Suzuki, T; Takahashi, T; Yamada, M; Yamaya, M1
Ando, S; Hirasawa, M; Makuuchi, H; Matsuda, M; Nishiyama, J; Suzuki, T1
Miao, QB; Shu, YS; Tao, W; Zhu, YB1
Futamura, M; Kawaguchi, Y; Morimitsu, K; Nawa, M; Nonaka, K; Osada, S; Yoshida, K1
Chen, HI; Kao, SJ; Lin, CC; Liu, PH1
Bhattacharya, K; Khatua, B; Mandal, C1
Axtell, RC; de Jong, BA; Dunn, C; Dunn, J; Goodyear, AL; Han, MH; Herges, K; Killestein, J; Ko, RM; Kolkowitz, I; Maini, A; Mandelbaum, G; Polman, C; Steinman, L1
Hanazaki, K; Kobayashi, M; Okabayashi, T; Shiga, M; Sugimoto, T; Takezaki, Y; Tsujii, S1
Fukuda, T; Ishii, Y; Takemasa, A1
Bao, R; Chen, H; Deng, X; Hou, J; Li, J; Liu, Y; Sun, L; Wang, J; Yang, T; Zhang, J; Zhu, X1
Feng, L; Huang, C; Li, Y; Zhu, W1
Du, W; Fujimura, N; Itano, O; Kawasako, K; Kitagawa, Y; Kitago, M; Maruyama, I; Matsuda, S; Matsumoto, K; Miyasho, T; Obara, H; Ono, S; Sakamoto, M; Shinoda, M; Suda, K; Takeuchi, H; Tanabe, M; Yagi, H; Yamada, S1
Masaoka, N; Nakajima, Y1
Fox, J; Haston, CK1
Cai, JH; Chai, JK; Chi, YF; Deng, HP; Feng, R; Hu, QG; Liu, W; Ma, L; Shen, CA; Yin, HN; Zhang, XB; Zou, XF1
Chen, L; Tang, AM; Wang, HH; Zhou, MT1
Mii, S; Nakazato, K; Sakamoto, A; Takeda, S; Tanaka, K; Tsuboko, Y; Uchida, E1
Abe, C; Binh, NH; Cuong, NT; Hara, A; Morita, H; Ogura, S1
Fuchimoto, Y; Gelfand, EW; Ikeda, G; Kanehiro, A; Kataoka, M; Koga, H; Miyahara, N; Ono, K; Tanimoto, M; Tanimoto, Y; Waseda, K1
Akita, K; Inomata, T; Narumi, Y; Okada, Y; Shimbo, T; Takahashi, M; Uesugi, Y; Yoshikawa, N1
Baba, H; Baba, Y; Hirashima, K; Iwatsuki, M; Karashima, R; Kinoshita, K; Kurashige, J; Nagai, Y; Watanabe, M1
Hwang, JJ; Kim, DH; Kim, KD; Lee, SK; Son, BS1
Aibiki, M; Dote, K; Hamada, H; Higaki, J; Irifune, K; Ito, R; Kanematsu, T; Katayama, H; Miyoshi, S; Nakanishi, N; Okura, T; Suwaki, T1
Angelos, MG; Aune, SE; Khan, M; Kuppusamy, ML; Kuppusamy, P; Yeh, ST1
Fujishima, S; Izumida, H1
Inoue, N; Itatani, K; Kitamura, T; Miyaji, K; Oka, N; Shibata, K; Tomoyasu, T1
Cao, J; Liu, Q1
Gao, YM; Hu, XX; Liu, BZ; Ma, PP; Wang, H; Zhang, X; Zhong, L; Zhu, D; Zhu, XY1
Fujii, M; Hanayama, N; Inoue, N; Itatani, K; Kitamura, T; Kohira, S; Miyaji, K; Oka, N; Oshima, H; Takeda, A; Tojo, K; Yoshitake, S1
Eguchi, T; Hamanaka, K; Hasegawa, J; Koizumi, T; Komatsu, Y; Kondo, R; Kubo, K; Shiina, T; Yamamoto, H; Yoshida, K1
Fukuda, K; Kawakubo, H; Kitagawa, Y; Kumagai, K; Miyasho, T; Nakamura, R; Saikawa, Y; Suda, K; Takahashi, T; Takeuchi, H; Wada, N1
Asano, M; Mishima, A; Nakayama, T; Nomura, N; Saito, T1
Choi, SY; Kim, H; Park, JS; Park, KH1
Fujimura, T; Fushida, S; Hayashi, H; Kitagawa, H; Makino, I; Miyashita, T; Munesue, S; Nakagawara, H; Nakanuma, S; Ohta, T; Saito, H; Sakai, S; Tajima, H; Yamamoto, Y1
Chen, K; Feng, L; Guo, F; Huang, C; Li, Y; Liu, X; Wang, R; Wu, Y; Zhu, W1
Chang, J; Chen, CH; Cheng, CC; Ho, AS; Lien, GS; Lin, HC; Luo, TY; Wang, CC1
Fang, QH; Jiang, YW; Yuan, Q1
Ito, H; Nakayama, H; Yamada, K; Yokose, T1
Hayashi, N; Matsumoto, S; Okamoto, H; Otsuka, T; Sakai, M; Takenami, T; Yoshino, K1
Katakura, K; Ohira, H; Shioya, Y1
Horai, T; Inoue, N; Itatani, K; Kitamura, T; Kohira, S; Miyaji, K; Oka, N; Oshima, H; Tojo, K; Yoshitake, S1
Chen, L; Gong, H; Ma, P; Tang, A; Wang, H; Wang, S1
Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H1
Aibiki, M; Dote, K; Hamada, H; Higaki, J; Ito, R; Katayama, H; Miyoshi, S; Okura, T1
Cai, J; Chen, LQ; Niu, ZX; Wang, WP; Wang, ZQ; Yang, YS; Yuan, Y1
Belcastro, R; Jankov, RP; Kantores, C; Li, J; Lopez, L; Masood, A; Tanswell, AK; Yi, M1
Bo, R; Hasegawa, Y; Ishige, N; Kobayashi, H; Nakamura, M; Takahashi, T; Yamada, K; Yamaguchi, S1
Dimitriadis, F; Hikita, K; Honda, M; Muraoka, K; Saito, M; Sejima, T; Shimizu, S; Sofikitis, N; Takenaka, A; Tomita, S; Tsounapi, P1
Carneiro, FS; de Caux, TR; Galvão, I; Lima, GL; Lima, KM; Nunes, FF; Perretti, M; Pinho, V; Ribeiro, AL; Sousa, LP; Sugimoto, MA; Tavares, LP; Teixeira, MM; Vago, JP1
Chen, XY; Dai, XJ; Wang, J; Wu, YL; Zhang, YF; Zhong, DF1
Huang, P; Li, QG; Xiao, XG; Zu, HG1
Shang, Y; Sun, Z; Xia, H; Yang, Y; Yao, S1
Dong, HL; Huo, J; Ma, R; Su, BX; Zhu, XL1
Liu, J; Liu, Y; Luo, Y; Ma, X; Shi, J; Wang, L; Xun, Y; Yang, W; Ye, D; Zang, S; Zhao, F; Zhu, G; Zhuang, Z1
Guo, Y; Li, T; Ma, L; Sun, R; Zhang, F1
Gong, X; Ji, K; Jia, J; Li, G; Wang, H; Wang, R; Zang, B; Zhang, X1
Imai, Y; Kawahara, M; Kuba, K; Mizushima, T; Sugizaki, T; Tamura, F; Tanaka, KI1
Asakawa, T; Fujino, Y; Kido, T; Kubo, T; Matsuda, S; Mayumi, T; Mukae, H; Muramatsu, K; Otsubo, H; Yatera, K1
Kim, IK; Kim, JW; Lee, DG; Lee, HY; Lee, JM; Lee, SH; Rhee, CK; Yeo, CD1
Imamura, T; Inoue, S; Kawaguchi, M; Kishimoto, M; Matsui, H; Myojin, T; Noda, T; Yamana, H; Yasunaga, H1
Arimura-Omori, M; Hamada, N; Harada, E; Ikeda-Harada, C; Mikumo, H; Nakanishi, Y; Ogata-Suetsugu, S; Suzuki, K; Yanagihara, T; Yokoyama, T1
Ando, K; Fukui, M; Matsunaga, T; Oh, S; Suzuki, K; Takamochi, K1
Krustev, E; McDougall, JJ; Muley, MM; Reid, AR1
Bali, KK; Kuner, R1
Bonno, M; Hokuto, I; Iida, K; Ito, M; Kageyama, M; Kato, Y; Matsumoto, N; Mori, R; Nakata, Y; Namba, F; Nishimura, Y; Ogawa, R; Oshiro, M; Takahashi, N; Tanaka, T; Uchida, Y1
Arakaki, R; Kise, Y; Kuniyoshi, Y; Yamashiro, S1
Bajorath, J; Blaut, M; Braune, A; Gilberg, E; Girbl, T; Gütschow, M; Nourshargh, S; Schulz-Fincke, AC; Tikhomirov, AS1
Attia, Z; Boyaka, PN; Cormet-Boyaka, E; Hassan, H; Kim, E; Rowe, JC; Satoskar, AR; Steiner, HE; Varikuti, S; Zaghawa, A1
Domon, H; Hiyoshi, T; Kawabata, S; Maekawa, T; Nagai, K; Oda, M; Takeda, W; Tamura, H; Terao, Y; Yamaguchi, M; Yonezawa, D1
Azuma, A; Bando, M; Date, H; Ebina, M; Fukuoka, J; Gemma, A; Goto, Y; Hasegawa, Y; Hattori, N; Homma, S; Inase, N; Inoue, Y; Ishii, Y; Izumi, S; Johkoh, T; Kido, T; Kishaba, T; Kishi, K; Miyamoto, A; Mukae, H; Nakayama, T; Nishioka, Y; Ogura, T; Sakamoto, S; Sasaki, S; Suda, T; Sugino, K; Taguchi, Y; Takahashi, H; Takahashi, K; Taniguchi, H; Watanabe, K; Yokoyama, A; Yoshino, I1
Dai, J; Fu, Z; Hu, J; Liu, E; Liu, J; Luo, Z; Niu, C; Tian, D; Wang, T; Xiong, Y; Ying, L; Zhang, M; Zou, L; Zou, W1
Ban, E; Bonanomi, D; Choi, H; Han, I; Jo, MJ; Joshi, HP; Kim, A; Kim, KT; Kim, SB; Kumar, H; Lee, SH; Muttigi, M; Sohn, S; Zeng, X1
Cai, J; Chen, J; Guan, J; Han, X; Hei, Z; Wu, S; Yao, W; Yuan, D1
Ageyama, N; Goto, Y; Hiramatsu, Y; Kitazawa, S; Mathis, BJ; Matsubara, M; Sakamoto, H; Sato, S; Sato, Y1
Kawakami, K; Kawasaki, Y; Kuwauchi, A; Nahara, I; Takeda, C; Takeuchi, M; Tanaka, S; Yonekura, H; Yoshida, S1
Bi, HW; Li, J; Zhang, GR; Zheng, JQ1
Domon, H; Hiyoshi, T; Maekawa, T; Miyoshi, T; Nagai, K; Tabeta, K; Takahashi, N; Tamura, H; Terao, Y; Yonezawa, D; Yoshida, A1
Ebata, R; Hamada, H; Hanaoka, H; Higashi, K; Homma, J; Kobayashi, H; Kohno, Y; Nagai, K; Okunushi, K; Saito, N; Saito, Y; Shimojo, N; Takada, N; Takechi, F; Yasukawa, K1
Fukuta, T; Kawaguchi, T; Kuroda, A; Maekawa, Y; Matsuo, S; Miyazaki, N; Morishita, K; Oda, K; Ogura, S; Okada, H; Sampei, S; Suzuki, K; Takada, C; Takemura, G; Tomita, H; Uchida, A; Ushikoshi, H; Watanabe, T; Yano, H; Yoshida, S; Yoshida, T; Zaikokuji, R1
Hayashi, H; Horinokita, I; Mizumura, R; Oteki, R; Takagi, N; Usui, A; Yamaguchi, T; Yuan, B1
Doi, T; Fukuda, H; Fukuta, T; Hotta, Y; Kuroda, A; Maekawa, Y; Matsuo, S; Miyazaki, N; Morishita, K; Muraki, I; Nishio, A; Oda, K; Ogura, S; Okada, H; Sampei, S; Suzuki, A; Suzuki, K; Takada, C; Takemura, G; Tomita, H; Uchida, A; Ushikoshi, H; Watanabe, T; Yamada, N; Yano, H; Yoshida, S; Yoshida, T; Zaikokuji, R1
Bessho, R; Fujii, M1
Colle, I; Debacker, PJ; Devisscher, L; Geerts, A; Lefere, S; Raevens, S; Van Campenhout, S; Van Vlierberghe, H; Verhelst, X1
Cheng, IY; Ho, WC; Hsu, HS; Hsu, JW; Hsu, TW; Hung, SC; Li, AF; Lin, JH; Liu, CC1
Arai, H; Ishikawa, Y; Ito, H; Maehara, T; Masuda, M; Morita, S; Morohoshi, T; Nagashima, T; Nakayama, H; Nishii, T; Tajiri, M; Watanabe, K; Woo, T; Yamamoto, T; Yokose, T1
Hu, S; Jin, J; Li, B; Li, T; Liu, Y; Liu, Z; Ma, S; Novakovic, VA; Shi, J; Sun, Q; Tian, J; Zhang, S; Zhao, H; Zhou, P1
Anahtar, MN; Bhatia, SN; Chan, LW; Hern, KE; Kunz, RR; Ong, TH1
Becker, C; Benoliel, JJ; Elbim, C; Frère, C; Hémadi, M; Laforge, M; Massaad, C; Nuss, P1
Avan, R; Bagheri, M; Habtemariam, S; Khataminia, M; Rezai Ghaleno, H; Sadremomtaz, A; Safdari, M; Saghafi, F; Sahebnasagh, A; Talaei, Z1
Al-Rejaie, S; ElMasry, G; Kishk, RM; Kishk, SM; Nafie, MS; Nemr, NA; Simons, C; Yassen, ASA1
Ahmad, A; Khan, MA; Khan, R; Mishra, RK; Prakash, R; Raza, SS1
Hayashi, H; Horinokita, I; Ichiyanagi, M; Imamura, Y; Iwatani, Y; Takagi, N; Yoshizawa, R1
Aykan, S; Colakerol, A; Gonultas, S; Kandırali, E; Kucuk, SH; Ozsoy, S; Semercioz, A; Suzan, S; Temiz, MZ; Yuruk, E1
Gao, X; Guo, X; Huang, L; Lei, Z; Tian, J; Yang, Y; Zhang, R1
Cui, Y; Ding, X; Li, H; Liang, H; Liu, S; Sun, T; Sun, Y; Wang, D; Wang, H; Zhang, X1
Banno-Terada, R; Endo, M; Fujii, T; Kohno, T; Maekawa, A; Mamiya, R; Nagi-Miura, N; Ohno, N; Takada, M; Takagaki, N; Tanaka, A; Tsuji, T; Yamada, A; Yoshida, Y1
Dong, T; Tian, W1

Reviews

14 review(s) available for sivelestat and glycine

ArticleYear
[Pathophysiology of acute lung injury].
    Nihon Kyobu Shikkan Gakkai zasshi, 1996, Volume: 34 Suppl

    Topics: Acute Disease; Animals; Biomarkers; Capillary Permeability; Cell Adhesion Molecules; Clinical Trials as Topic; Glycine; Humans; Leukocyte Elastase; Lung; Lung Diseases; Nitric Oxide; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sulfonamides

1996
[How can we monitor and treat patients with acute exacerbations of idiopathic interstitial pneumonia].
    Nihon Kyobu Shikkan Gakkai zasshi, 1996, Volume: 34 Suppl

    Topics: Acute-Phase Reaction; Anti-Inflammatory Agents; Antigens; Antigens, Neoplasm; Biomarkers; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Glycine; Glycoproteins; Humans; Lung Diseases, Interstitial; Methylprednisolone; Monitoring, Physiologic; Mucin-1; Mucins; Serine Proteinase Inhibitors; Sulfonamides

1996
[Strategy of therapy for interstitial lung disease due to chemotherapeutic drugs or radiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24 Suppl 3

    Topics: Animals; Antineoplastic Agents; Bleomycin; Drug Administration Schedule; Glycine; Humans; Lung Diseases, Interstitial; Lung Neoplasms; Methylprednisolone; Mice; Prednisolone; Pulmonary Fibrosis; Radiation Injuries; Serine Proteinase Inhibitors; Sulfonamides

1997
[The 74th Annual Meeting President Lecture. Pathogenesis and therapy of acute lung injury].
    Kekkaku : [Tuberculosis], 1999, Volume: 74, Issue:9

    Topics: Glycine; Humans; Leukocyte Elastase; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides

1999
[Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2003, Volume: 122, Issue:2

    Topics: Animals; Clinical Trials, Phase III as Topic; Disease Models, Animal; Glycine; Humans; Leukocyte Elastase; Serpins; Sulfonamides; Systemic Inflammatory Response Syndrome

2003
Update in ARDS management: recent randomized controlled trials that changed our practice.
    Cleveland Clinic journal of medicine, 2006, Volume: 73, Issue:3

    Topics: Glycine; High-Frequency Ventilation; Humans; Liquid Ventilation; Nitric Oxide; Ohio; Positive-Pressure Respiration; Prone Position; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Tidal Volume

2006
[Sivelestat sodium for aspiration-related acute lung injury: a review and analysis of published case reports].
    Masui. The Japanese journal of anesthesiology, 2006, Volume: 55, Issue:6

    Topics: Aged; Aged, 80 and over; Female; Glycine; Humans; Male; Middle Aged; Pneumonia, Aspiration; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Ventilator Weaning

2006
Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.
    Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:22

    Topics: Acute Lung Injury; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sulfonamides

2010
Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase.
    Medicinal research reviews, 2013, Volume: 33 Suppl 1

    Topics: Enzyme Inhibitors; Glycine; Humans; Molecular Weight; Proteinase Inhibitory Proteins, Secretory; Pulmonary Disease, Chronic Obstructive; Serine Proteinase Inhibitors; Sulfonamides

2013
[Pharmacological therapies for ARDS].
    Masui. The Japanese journal of anesthesiology, 2013, Volume: 62, Issue:5

    Topics: Animals; Anticoagulants; Atracurium; Disseminated Intravascular Coagulation; Glycine; Humans; Meta-Analysis as Topic; Methylprednisolone; Neuromuscular Blocking Agents; Protein C; Proteinase Inhibitory Proteins, Secretory; Pulse Therapy, Drug; Randomized Controlled Trials as Topic; Recombinant Proteins; Respiratory Distress Syndrome; Sulfonamides

2013
Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy: a systematic review and meta-analysis.
    World journal of gastroenterology, 2015, Mar-28, Volume: 21, Issue:12

    Topics: Acute Lung Injury; Aged; Esophagectomy; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Odds Ratio; Respiration, Artificial; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome

2015
[Effect of sivelestat sodium on the prognosis of patients with acute lung injury and acute respiratory distress syndrome: a meta-analysis].
    Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:10

    Topics: Acute Lung Injury; China; Glycine; Humans; Intensive Care Units; Length of Stay; Prognosis; Randomized Controlled Trials as Topic; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides

2015
Japanese guideline for the treatment of idiopathic pulmonary fibrosis.
    Respiratory investigation, 2018, Volume: 56, Issue:4

    Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Comorbidity; Disease Progression; Drug Therapy, Combination; Evidence-Based Medicine; Glycine; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Indoles; Japan; Lung Neoplasms; Meta-Analysis as Topic; Practice Guidelines as Topic; Prognosis; Pyridones; Quality of Health Care; Sulfonamides; Survival Rate

2018
Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
    Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:6

    Topics: Acute Lung Injury; COVID-19; COVID-19 Drug Treatment; Disseminated Intravascular Coagulation; Glycine; Humans; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sulfonamides; Treatment Outcome

2020

Trials

28 trial(s) available for sivelestat and glycine

ArticleYear
Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study.
    Critical care medicine, 2004, Volume: 32, Issue:8

    Topics: Australia; Belgium; Canada; Double-Blind Method; Female; Follow-Up Studies; Glycine; Guideline Adherence; Humans; Infusions, Intravenous; Leukocyte Elastase; Male; Middle Aged; New Zealand; Outcome and Process Assessment, Health Care; Prospective Studies; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Spain; Sulfonamides; Survival Analysis; Tidal Volume; Time; Treatment Outcome; United States

2004
Pilot study of the effects of ONO-5046 in patients with acute respiratory distress syndrome.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:3

    Topics: Adult; Aged; Cytokines; Double-Blind Method; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Pilot Projects; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides

2004
Relationship between neutrophil elastase and acute lung injury in humans.
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glycine; Humans; Intensive Care Units; Length of Stay; Leukocyte Elastase; Male; Middle Aged; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Ventilator Weaning

2004
[Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].
    Masui. The Japanese journal of anesthesiology, 2005, Volume: 54, Issue:8

    Topics: Cytokines; Esophageal Neoplasms; Esophagectomy; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Lung Diseases; Postoperative Complications; Postoperative Period; Respiration, Artificial; Serpins; Sulfonamides; Time Factors

2005
Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
    Surgery today, 2006, Volume: 36, Issue:4

    Topics: Acute Disease; Aged; Cardiopulmonary Bypass; Female; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Perfusion; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome

2006
A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury.
    The Journal of trauma, 2006, Volume: 60, Issue:5

    Topics: Adult; Aged; APACHE; C-Reactive Protein; Cell Membrane; Elasticity; Female; Glycine; Humans; Leukocyte Count; Leukocyte Elastase; Leukocytes; Lung; Lung Injury; Male; Microcirculation; Middle Aged; Norepinephrine; Oxygen; Positive-Pressure Respiration; Respiratory Distress Syndrome; Rheology; Sulfonamides; Systemic Inflammatory Response Syndrome; Total Lung Capacity

2006
Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery.
    Surgery today, 2007, Volume: 37, Issue:5

    Topics: Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Digestive System Neoplasms; Digestive System Surgical Procedures; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Leukocyte Elastase; Liver Neoplasms; Male; Middle Aged; Pancreaticoduodenectomy; Postoperative Period; Prospective Studies; Serine Proteinase Inhibitors; Single-Blind Method; Stress, Physiological; Sulfonamides; Th1 Cells; Th2 Cells

2007
Neutrophil elastase as a predicting factor for development of acute lung injury.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Predictive Value of Tests; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome

2007
Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction.
    Research communications in molecular pathology and pharmacology, 2006, Volume: 119, Issue:1-6

    Topics: Acute Disease; Adolescent; Adult; Aged; Glycine; Humans; Interleukin-8; Leukocyte Elastase; Leukocytes; Middle Aged; Oxygen; Pulmonary Circulation; Pulmonary Surfactant-Associated Protein D; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Systemic Inflammatory Response Syndrome; Treatment Outcome; Tumor Necrosis Factor-alpha

2006
[Effect of sivelestat sodium on acute lung injury after acute aortic dissection].
    Kyobu geka. The Japanese journal of thoracic surgery, 2008, Volume: 61, Issue:6

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aortic Aneurysm; Aortic Dissection; Female; Glycine; Humans; Infusions, Intravenous; Leukocyte Elastase; Logistic Models; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Respiratory Insufficiency; Sulfonamides

2008
A pilot randomized study of the neutrophil elastase inhibitor, Sivelestat, in patients undergoing cardiac surgery.
    Interactive cardiovascular and thoracic surgery, 2009, Volume: 9, Issue:2

    Topics: Aged; Atrial Fibrillation; Cardiopulmonary Bypass; Coronary Artery Bypass; Feasibility Studies; Female; Glycine; Humans; Infusions, Intravenous; Length of Stay; Leukocyte Elastase; Lung Compliance; Lung Injury; Male; Middle Aged; Pilot Projects; Pulmonary Circulation; Serine Proteinase Inhibitors; Sulfonamides; Surgical Wound Infection; Time Factors; Treatment Outcome

2009
Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2010, Volume: 23, Issue:4

    Topics: Acute Lung Injury; Aged; Double-Blind Method; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Male; Middle Aged; Perioperative Care; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgery, Video-Assisted

2010
Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass.
    Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:6

    Topics: Acute Lung Injury; Aged; Anti-Inflammatory Agents; Aortic Valve; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cardiopulmonary Bypass; Female; Glycine; Heart Valve Prosthesis Implantation; Humans; Inflammation Mediators; Infusions, Intravenous; Interleukin-6; Interleukin-8; Leukocyte Elastase; Lung; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Pulmonary Gas Exchange; Sulfonamides; Time Factors; Treatment Outcome

2010
Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation.
    Transplantation, 2010, Aug-15, Volume: 90, Issue:3

    Topics: Acute Lung Injury; Glycine; Humans; Infusions, Intravenous; Leukocyte Elastase; Liver Transplantation; Pilot Projects; Prospective Studies; Protease Inhibitors; Sulfonamides; Time Factors; Treatment Outcome

2010
Optimal period for the prophylactic administration of neutrophil elastase inhibitor for patients with esophageal cancer undergoing esophagectomy.
    World journal of surgery, 2011, Volume: 35, Issue:7

    Topics: Aged; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Lung Diseases; Male; Middle Aged; Postoperative Care; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

2011
Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study.
    Pulmonary pharmacology & therapeutics, 2011, Volume: 24, Issue:5

    Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Infusions, Intravenous; Male; Middle Aged; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Systemic Inflammatory Response Syndrome; Ventilator Weaning

2011
Perioperative use of a neutrophil elastase inhibitor in video-assisted thoracoscopic oesophagectomy for cancer.
    The British journal of surgery, 2011, Volume: 98, Issue:7

    Topics: Aged; Critical Care; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Intraoperative Care; Length of Stay; Lymph Node Excision; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Thoracic Surgery, Video-Assisted

2011
Effects of sivelestat on bronchial inflammatory responses after esophagectomy.
    International journal of molecular medicine, 2011, Volume: 28, Issue:2

    Topics: Acute Lung Injury; Aged; Bronchitis; Esophagectomy; Female; Glycine; Humans; Interleukin-6; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; Postoperative Complications; Premedication; Respiratory Distress Syndrome; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome

2011
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2011, Volume: 17, Issue:4

    Topics: Aged; Aged, 80 and over; Aorta, Thoracic; Chi-Square Distribution; Female; Glycine; Hospital Mortality; Humans; Hypothermia, Induced; Infusions, Parenteral; Intensive Care Units; Japan; Length of Stay; Leukocyte Elastase; Lung; Male; Respiration, Artificial; Respiratory Insufficiency; Serine Proteinase Inhibitors; Severity of Illness Index; Sulfonamides; Time Factors; Treatment Outcome; Vascular Surgical Procedures; Ventilator Weaning

2011
The effect of the neutrophil elastase inhibitor sivelestat on early injury after liver resection.
    World journal of surgery, 2012, Volume: 36, Issue:5

    Topics: Aged; Biomarkers; Drug Administration Schedule; Female; Glycine; Hepatectomy; HMGB1 Protein; Humans; Interleukin-6; Leukocyte Elastase; Liver; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2012
Neutrophil elastase inhibitor sivelestat attenuates perioperative inflammatory response in pediatric heart surgery with cardiopulmonary bypass.
    International heart journal, 2013, Volume: 54, Issue:3

    Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Female; Glycine; Humans; Infant; Inflammation; Male; Neutrophils; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome

2013
Effect of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass: a prospective randomized study.
    Artificial organs, 2013, Volume: 37, Issue:12

    Topics: Age Factors; Anti-Inflammatory Agents; Blood Coagulation; Blood Loss, Surgical; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Double-Blind Method; Elective Surgical Procedures; Glycine; Humans; Infant; Inflammation; Inflammation Mediators; Infusions, Intravenous; Japan; Leukocyte Count; Leukocyte Elastase; Platelet Count; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome

2013
Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung re-expansion following one-lung ventilation during thoracic surgery.
    Inflammation, 2013, Volume: 36, Issue:6

    Topics: Actin Cytoskeleton; Actins; Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Interleukin-8; Lung; Male; Malondialdehyde; Middle Aged; Neutrophils; One-Lung Ventilation; Oxygen; Serine Proteinase Inhibitors; Sulfonamides; Thoracic Surgical Procedures

2013
Sivelestat attenuates lung injury in surgery for congenital heart disease with pulmonary hypertension.
    The Annals of thoracic surgery, 2013, Volume: 96, Issue:6

    Topics: Blood Pressure; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Glycine; Heart Septal Defects, Ventricular; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Intraoperative Period; Lung Injury; Male; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome; Vascular Resistance

2013
Prophylaxis for acute exacerbation of interstitial pneumonia after lung resection.
    Asian cardiovascular & thoracic annals, 2014, Volume: 22, Issue:8

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Glucocorticoids; Glycine; Humans; Idiopathic Interstitial Pneumonias; Infusions, Intravenous; Injections, Intravenous; Japan; Lung Neoplasms; Male; Methylprednisolone; Middle Aged; Pilot Projects; Pneumonectomy; Preoperative Care; Prospective Studies; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tomography, X-Ray Computed; Treatment Outcome

2014
Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias.
    The Annals of thoracic surgery, 2017, Volume: 103, Issue:6

    Topics: Aged; Biomarkers; Female; Glycine; Humans; Idiopathic Interstitial Pneumonias; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Perioperative Care; Pneumonectomy; Postoperative Complications; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Secondary Prevention; Sulfonamides; Survival Analysis

2017
Sivelestat sodium hydrate treatment for refractory Kawasaki disease.
    Pediatrics international : official journal of the Japan Pediatric Society, 2019, Volume: 61, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Glycine; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant; Male; Mucocutaneous Lymph Node Syndrome; Pilot Projects; Prospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2019
A prophylaxis study of acute exacerbation of interstitial pneumonia after lung cancer surgery.
    Japanese journal of clinical oncology, 2020, Feb-17, Volume: 50, Issue:2

    Topics: Aged; Anti-Inflammatory Agents; Female; Glycine; Humans; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Male; Methylprednisolone; Postoperative Complications; Preoperative Care; Prospective Studies; Sulfonamides; Survival Rate; Symptom Flare Up

2020

Other Studies

268 other study(ies) available for sivelestat and glycine

ArticleYear
Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes.
    Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 12

    Topics: Cathepsin G; Cathepsins; Chromatography, High Pressure Liquid; Coumarins; Cytosol; Endothelin-1; Endothelins; Glycine; Humans; Isocoumarins; Leukocyte Elastase; Mass Spectrometry; Neutrophils; Pancreatic Elastase; Protein Precursors; Serine Endopeptidases; Sulfonamides

1992
ONO-5046, a novel inhibitor of human neutrophil elastase.
    Biochemical and biophysical research communications, 1991, Jun-14, Volume: 177, Issue:2

    Topics: Animals; Binding, Competitive; Capillary Permeability; Cricetinae; Glycine; Guinea Pigs; Hemorrhage; Humans; Lung Diseases; Male; Mesocricetus; Mice; Neutrophils; Pancreatic Elastase; Rabbits; Rats; Skin Diseases; Sulfonamides

1991
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
    Thrombosis research, 1995, Apr-15, Volume: 78, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Anticoagulants; Antithrombin III; Capillary Permeability; Dansyl Compounds; Endotoxins; Factor Xa; Fibrin Fibrinogen Degradation Products; Glycine; Heparin; Injections, Intravenous; Leukocyte Elastase; Leukopenia; Lipopolysaccharides; Lung; Male; Methotrexate; Molecular Sequence Data; Neutrophils; Pancreatic Elastase; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Wistar; Shock, Septic; Specific Pathogen-Free Organisms; Sulfonamides

1995
A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster.
    The European respiratory journal, 1995, Volume: 8, Issue:8

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemotaxis, Leukocyte; Cricetinae; Glycine; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Mesocricetus; Neutrophils; Organ Size; Pancreatic Elastase; Pneumonia; Respiratory Distress Syndrome; Sulfonamides

1995
Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep.
    Respiration physiology, 1995, Volume: 100, Issue:1

    Topics: Airway Resistance; Animals; Antigens; Asthma; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Glycine; Heterocyclic Compounds; Leukocyte Elastase; Leukocytes; Leukotriene B4; Masoprocol; Methacholine Chloride; Pancreatic Elastase; Polycyclic Compounds; Sheep; Sulfonamides; Thromboxane B2

1995
Substance P stimulates the loss of cell-associated high molecular weight glycoconjugates from cultured hamster tracheal epithelial cells through polymorphonuclear leucocytes activation.
    Biochemistry and molecular biology international, 1995, Volume: 36, Issue:5

    Topics: Animals; Cells, Cultured; Cricetinae; Epithelial Cells; Epithelium; Glycine; Glycoconjugates; Male; Mesocricetus; Molecular Weight; Mucous Membrane; Neutrophil Activation; Pancreatic Elastase; Serine Proteinase Inhibitors; Substance P; Sulfonamides; Trachea

1995
Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:10

    Topics: Animals; Ceruletide; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Hemorrhage; Leukocyte Elastase; Lipopolysaccharides; Lung Diseases; Macrophages, Peritoneal; Male; Organ Size; Pancreas; Pancreatic Elastase; Pancreatitis; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha

1995
Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis.
    Cellular immunology, 1995, Oct-01, Volume: 165, Issue:1

    Topics: Animals; Antibody Formation; Arthritis, Experimental; Collagen; Female; Glycine; Immunity, Cellular; Male; Mice; Mice, Inbred DBA; Rats; Rats, Inbred BB; Serine Proteinase Inhibitors; Sulfonamides

1995
Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bacteremia; Blood Gas Analysis; Endotoxins; Escherichia coli Infections; Esterases; Glycine; Hypertension, Pulmonary; Leukocytes; Lung Diseases; Lymph; Neutrophils; Pulmonary Circulation; Sheep; Sulfonamides; Thromboxane B2

1994
Simultaneous determination of human neutrophil elastase inhibitor (ONO-5046) and its metabolite in plasma and urine by direct injection column-switching HPLC.
    Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:3

    Topics: Chromatography, High Pressure Liquid; Glycine; Humans; Leukocyte Elastase; Pancreatic Elastase; Reproducibility of Results; Sulfonamides

1994
Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:1

    Topics: Animals; Capillary Permeability; Female; Glycine; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Lung Diseases; Male; Neutrophils; Organ Size; Pancreatic Elastase; Pulmonary Circulation; Pulmonary Edema; Rabbits; Sulfonamides; Superoxide Dismutase; Superoxides

1994
Production of IL-1 and IL-1 receptor antagonist and the pathological significance in lipopolysaccharide-induced arthritis in rabbits.
    Clinical and experimental immunology, 1993, Volume: 93, Issue:2

    Topics: Animals; Arthritis; Female; Glycine; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Leukocyte Elastase; Leukopenia; Lipopolysaccharides; Pancreatic Elastase; Proteoglycans; Rabbits; Sialoglycoproteins; Sulfonamides

1993
Interaction between neutrophil-derived elastase and reactive oxygen species in cartilage degradation.
    Biochimica et biophysica acta, 1993, Mar-21, Volume: 1156, Issue:3

    Topics: Animals; Cartilage; Cathepsin G; Cathepsins; Cattle; Cells, Cultured; Enzyme Activation; Glucuronidase; Glycine; Leukocyte Elastase; Luminescent Measurements; Pancreatic Elastase; Rats; Reactive Oxygen Species; Serine Endopeptidases; Sulfonamides

1993
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
    American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:1

    Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemotaxis; Escherichia coli; Glycine; Guinea Pigs; In Vitro Techniques; Leukocyte Elastase; Lipopolysaccharides; Lung; Lung Diseases; Male; Neutrophils; Pancreatic Elastase; Serine Proteinase Inhibitors; Sulfonamides

1996
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
    Blood, 1996, Jan-15, Volume: 87, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Animals; Anticoagulants; Antithrombin III; Capillary Permeability; Chemotaxis, Leukocyte; Disseminated Intravascular Coagulation; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Factor Xa; Fibrin Fibrinogen Degradation Products; Fibrinogen; Glycine; Heparin; Leukocyte Elastase; Leukopenia; Lipopolysaccharides; Lung; Male; Molecular Sequence Data; Pancreatic Elastase; Peroxidase; Protein C; Pulmonary Circulation; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Sulfonamides; Thrombin; Tumor Necrosis Factor-alpha

1996
Neutrophil elastase inhibitor (ONO-5046) decreases cytokine-induced neutrophil chemoattractant after reperfusion of pancreaticoduodenal transplantation in rats.
    Transplantation, 1996, Apr-15, Volume: 61, Issue:7

    Topics: Animals; Chemokines, CXC; Chemotactic Factors; Duodenum; Glycine; Growth Substances; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Male; Pancreas Transplantation; Pancreatic Elastase; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

1996
Effects of neutrophil elastase inhibitor on reperfusion injury in the canine liver.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Glycine; Hyaluronic Acid; Ischemia; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver; Pancreatic Elastase; Purine-Nucleoside Phosphorylase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

1996
Effects of a specific neutrophil elastase inhibitor (ONO-5046 Na) and neutrophil depletion using a G-1 column on lung reperfusion injury in dogs.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Animals; Chromatography; Dogs; Glycine; Graft Survival; Ischemia; Leukapheresis; Leukocyte Count; Leukocyte Elastase; Lung; Lung Transplantation; Neutrophils; Pancreatic Elastase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

1996
Role of granulocyte elastase in the formation of hemorrhagic shock-induced gastric mucosal lesions in the rat.
    Critical care medicine, 1996, Volume: 24, Issue:6

    Topics: Animals; Cells, Cultured; Endothelium, Vascular; Gastric Mucosa; Glycine; Humans; Leukocyte Elastase; Male; Pancreatic Elastase; Phlebotomy; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Shock, Hemorrhagic; Stomach Ulcer; Sulfonamides

1996
Role of granulocyte elastase in ischemia/reperfusion injury of rat liver.
    Critical care medicine, 1996, Volume: 24, Issue:11

    Topics: Animals; Bile; Coloring Agents; Glycine; Indocyanine Green; Leukocyte Elastase; Liver; Male; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Transaminases

1996
Non-peptidic inhibitors of human neutrophil elastase: the design and synthesis of sulfonanilide-containing inhibitors.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:12

    Topics: Aniline Compounds; Animals; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Glycine; Guinea Pigs; Humans; Leukocyte Elastase; Male; Neutrophils; Serine Proteinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Sulfonamides

1996
Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver.
    Gastroenterology, 1997, Volume: 112, Issue:2

    Topics: Animals; Antithrombin III; Aspartate Aminotransferases; Chemokines, CXC; Chemotactic Factors; Drug Synergism; Glycine; Growth Substances; Heparin; Intercellular Signaling Peptides and Proteins; Ischemia; Leukocyte Count; Leukocyte Elastase; Liver; Liver Circulation; Male; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides

1997
Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:2

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidine; Gastric Mucosa; Glycine; Humans; In Vitro Techniques; Indomethacin; Leukocyte Elastase; Male; Neutrophil Activation; Neutrophils; Peroxidase; Quinolones; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides

1997
The role of neutrophil elastase in human pulmonary artery endothelial cell injury.
    International archives of allergy and immunology, 1997, Volume: 112, Issue:3

    Topics: Endothelium, Vascular; Erythromycin; Glycine; Humans; L-Lactate Dehydrogenase; Leukocyte Elastase; Neutrophils; Pulmonary Artery; Serine Proteinase Inhibitors; Sulfonamides

1997
Leukocyte depletion and ONO-5046, a specific inhibitor of granulocyte elastase, prevent a stress-induced decrease in gastric prostaglandin I2 in rats.
    Biochemical and biophysical research communications, 1997, Feb-03, Volume: 231, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Gastric Mucosa; Glycine; Iloprost; Leukocyte Elastase; Leukocytes; Leukopenia; Male; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Stress, Physiological; Sulfonamides

1997
ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:5

    Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Endotoxins; Escherichia coli; Glycine; Hemodynamics; Leukocyte Count; Lung; Lung Compliance; Male; Organ Size; Pancreatic Elastase; Platelet Count; Rabbits; Respiratory Distress Syndrome; Sulfonamides

1997
First-pass metabolism of ONO-5046 (N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino]benzoyl]aminoacetic acid), a novel elastase inhibitor, in rats.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:4

    Topics: Animals; Biological Availability; Duodenum; Glycine; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Pancreatic Elastase; Portal Vein; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides

1997
Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice.
    American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:1

    Topics: Animals; Bleomycin; Glycine; Leukocyte Elastase; Male; Mice; Neutrophils; Pulmonary Fibrosis; Serine Proteinase Inhibitors; Sulfonamides

1997
[Role of neutrophil elastase in allergen-induced airway microvascular leakage in sensitized guinea pigs].
    Arerugi = [Allergy], 1997, Volume: 46, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Dose-Response Relationship, Drug; Glycine; Guinea Pigs; Humans; Hypersensitivity, Immediate; Leukocyte Count; Leukocyte Elastase; Male; Ovalbumin; Sulfonamides

1997
Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits.
    Anesthesiology, 1997, Volume: 87, Issue:3

    Topics: Animals; Bronchoalveolar Lavage Fluid; Glycine; Hemodynamics; Leukocyte Count; Leukocyte Elastase; Neutrophils; Peroxidase; Pneumonia, Aspiration; Rabbits; Serine Proteinase Inhibitors; Sulfonamides

1997
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
    The Journal of laboratory and clinical medicine, 1997, Volume: 130, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cephalosporins; Cimetidine; Gastric Mucosa; Glycine; Granulocytes; Indomethacin; Leukocyte Elastase; Male; Methotrexate; Microcirculation; Neutrophil Activation; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Specific Pathogen-Free Organisms; Stomach Diseases; Sulfonamides

1997
Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Division; Female; Glycine; Humans; Leukocyte Elastase; Lung Neoplasms; Mice; Mice, SCID; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Tumor Cells, Cultured

1997
ONO-5046, an elastase inhibitor, attenuates liver mitochondrial dysfunction after endotoxin.
    Critical care medicine, 1998, Volume: 26, Issue:1

    Topics: Adenosine Diphosphate; Animals; Blood Pressure; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Escherichia coli; Glycine; Guinea Pigs; Ketone Bodies; Leukocyte Elastase; Lipopolysaccharides; Liver Diseases; Male; Mitochondria, Liver; Oxygen; Phosphorylation; Respiration; Serine Proteinase Inhibitors; Sulfonamides

1998
Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 98, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Movement; Chemotaxis; Glycine; Humans; Leukocyte Elastase; Pancreatic Neoplasms; Serine Proteinase Inhibitors; Sulfonamides; Tumor Cells, Cultured

1997
Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na).
    Research communications in molecular pathology and pharmacology, 1997, Volume: 98, Issue:1

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Endothelium, Vascular; Glycine; Humans; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lung Neoplasms; Rats; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured

1997
Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs.
    American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:1

    Topics: Animals; Capillary Permeability; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Infusions, Intravenous; Leukocyte Elastase; Neutrophil Activation; Pulmonary Wedge Pressure; Rabbits; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

1998
Effect of human neutrophil elastase on tracheal mucociliary transport in anesthetized quails.
    Japanese journal of pharmacology, 1997, Volume: 75, Issue:4

    Topics: Animals; Bronchoalveolar Lavage Fluid; DNA; Dose-Response Relationship, Drug; Fucose; Glycine; Humans; Leukocyte Elastase; Male; Mucociliary Clearance; Mucous Membrane; Proteins; Quail; Serine Proteinase Inhibitors; Sulfonamides; Trachea

1997
Interleukin-8 as an essential factor in the human chorionic gonadotropin-induced rabbit ovulatory process: interleukin-8 induces neutrophil accumulation and activation in ovulation.
    Biology of reproduction, 1998, Volume: 58, Issue:2

    Topics: Animals; Chorionic Gonadotropin; Female; Glycine; Humans; Interleukin-8; Neutrophil Activation; Neutrophils; Ovary; Ovulation; Peroxidase; Rabbits; Serine Proteinase Inhibitors; Sulfonamides

1998
Neutrophil elastase inhibitor (ONO-5046.Na) decreases production of proinflammatory cytokines by lipopolysaccharide-stimulated human monocytes.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 98, Issue:3

    Topics: Cells, Cultured; Cytokines; Glycine; Humans; Interleukin-1; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Monocytes; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha

1997
Role of leukotriene B4 in bronchial hyperresponsiveness induced by interleukin-8.
    The European respiratory journal, 1998, Volume: 11, Issue:2

    Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Glycine; Guinea Pigs; Immunosuppressive Agents; Interleukin-8; Leukocyte Elastase; Leukotriene B4; Male; Neutrophils; Phenylpropionates; Sulfonamides

1998
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
    Kidney international, 1998, Volume: 53, Issue:5

    Topics: Animals; Antibodies, Heterophile; Basement Membrane; Disease Models, Animal; Glycine; Hematuria; Humans; Kidney Glomerulus; Leukocyte Elastase; Macrophages; Male; Monocytes; Nephritis; Proteinuria; Rats; Rats, Inbred WKY; Serine Proteinase Inhibitors; Sulfonamides

1998
Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:4

    Topics: Animals; Drug Stability; Glycine; Half-Life; In Vitro Techniques; Leukocyte Elastase; Liver; Male; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides

1998
Neutrophil elastase enhances intercellular adhesion molecule-1 expression.
    Transplantation, 1998, Jun-27, Volume: 65, Issue:12

    Topics: Animals; Calcium; Cells, Cultured; Endothelium, Vascular; Glycine; Humans; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Male; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Sulfonamides; Type C Phospholipases

1998
ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy.
    European journal of pharmacology, 1998, Jul-24, Volume: 353, Issue:2-3

    Topics: alpha 1-Antitrypsin; Glycine; Humans; Leukocyte Elastase; Pleural Effusion; Pneumonectomy; Serine Proteinase Inhibitors; Sulfonamides

1998
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (1). Single-dose intravenous toxicity studies in rats and dogs].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Weight; Bronchi; Dogs; Eating; Female; Glycine; Injections, Intravenous; L-Lactate Dehydrogenase; Lethal Dose 50; Lung; Male; Motor Activity; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides

1998
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (2). 4-week repeated dose intravenous toxicity study in rats with 4-week recovery test].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Blood; Body Weight; Eating; Eye; Female; Glycine; Injections, Intravenous; Kidney; Lung; Male; Motor Activity; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

1998
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). 4-week repeated dose intravenous toxicity study in dogs with 4-week recovery test].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Cardiovascular System; Dogs; Erythrocyte Count; Female; Glycine; Injections, Intravenous; Kidney; Lung; Male; No-Observed-Adverse-Effect Level; Organ Size; Retina; Serine Proteinase Inhibitors; Sulfonamides

1998
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (4). 6-month repeated dose intravenous toxicity study in rats with 1-month recovery test].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Blood Cell Count; Female; Glycine; Heart; Injections, Intravenous; Lung; Male; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Urinary Bladder

1998
[Toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (5). 6-month repeated dose intravenous toxicity study in dogs with 1-month recovery test].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Body Weight; Dogs; Ear, External; Female; Gait; Glycine; Injections, Intravenous; Male; No-Observed-Adverse-Effect Level; Organ Size; Respiration; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

1998
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na (1). Fertility study in rats].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Body Weight; Embryonic and Fetal Development; Female; Fertility; Glycine; Injections, Intravenous; Male; No-Observed-Adverse-Effect Level; Organ Size; Pituitary Gland; Pregnancy; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides

1998
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (2). Study for effects on pre- and postnatal development in rats, including maternal function
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Female; Glycine; Injections, Intravenous; Learning; Male; No-Observed-Adverse-Effect Level; Organ Size; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Reproduction; Serine Proteinase Inhibitors; Sulfonamides

1998
[Reproductive and developmental toxicity study of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na) (3). Teratogenicity study in rabbits].
    The Journal of toxicological sciences, 1998, Volume: 23 Suppl 3

    Topics: Animals; Body Weight; Eating; Embryonic and Fetal Development; Female; Glycine; Injections, Intravenous; No-Observed-Adverse-Effect Level; Pregnancy; Pregnancy, Animal; Rabbits; Serine Proteinase Inhibitors; Sulfonamides

1998
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
    The Journal of laboratory and clinical medicine, 1998, Volume: 132, Issue:5

    Topics: Animals; Capillary Permeability; Cephalosporins; Disease Models, Animal; Gastric Mucosa; Glycine; Leukocyte Elastase; Leukopenia; Male; Mechlorethamine; Neutrophils; Peptic Ulcer; Peroxidase; Rats; Rats, Wistar; Restraint, Physical; Serine Proteinase Inhibitors; Specific Pathogen-Free Organisms; Stress, Physiological; Sulfonamides

1998
The effect of neutrophil elastase inhibitor in hepatectomy with ischemia in dogs.
    The Journal of surgical research, 1999, Volume: 81, Issue:2

    Topics: Alanine Transaminase; Animals; Biomarkers; Dogs; Endothelium, Vascular; Glycine; Hemorrhage; Hepatectomy; Hyaluronic Acid; Ischemia; L-Lactate Dehydrogenase; Leukocyte Elastase; Liver; Liver Circulation; Portal System; Purine-Nucleoside Phosphorylase; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

1999
Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
    Journal of hepato-biliary-pancreatic surgery, 1998, Volume: 5, Issue:4

    Topics: alpha-Macroglobulins; Amylases; Animals; Blood Pressure; Calcium; Disease Models, Animal; Dogs; Glycine; Hematocrit; Hemorrhage; Leukocyte Count; Lipopolysaccharides; Multiple Organ Failure; Organ Size; Pancreatitis; Serine Proteinase Inhibitors; Sulfonamides

1998
Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways.
    The American journal of physiology, 1999, Volume: 276, Issue:2

    Topics: Animals; Anti-Allergic Agents; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Movement; Cyclophosphamide; Dose-Response Relationship, Drug; Glycine; Leukocyte Elastase; Male; Microcirculation; Neutrophils; Phthalazines; Platelet Activating Factor; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Sulfonamides

1999
The effects of a neutrophil elastase inhibitor (ONO-5046.Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:7

    Topics: Animals; Dogs; Drug Evaluation, Preclinical; Glycine; Hemodynamics; Leukapheresis; Leukocyte Elastase; Lung; Neutrophils; Organ Size; Random Allocation; Recombinant Proteins; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

1999
Effect of specific neutrophil elastase inhibitor on ischemia/reperfusion injury in rat liver transplantation.
    The Journal of surgical research, 1999, Volume: 86, Issue:1

    Topics: Adenine Nucleotides; Animals; Bile; Glycine; Hyaluronic Acid; Ischemia; Leukocyte Elastase; Liver; Liver Circulation; Liver Transplantation; Male; Rats; Rats, Inbred Lew; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

1999
Neutrophil elastase inhibitor (ONO-5046) attenuates reperfusion-induced hepatic microcirculatory derangement, energy depletion and lipid peroxidation in rats.
    Shock (Augusta, Ga.), 1999, Volume: 12, Issue:6

    Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Glycine; Hemodynamics; Ischemia; Laser-Doppler Flowmetry; Leukocyte Elastase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Microcirculation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Ultrasonography

1999
Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein- expression after ischemia/reperfusion in rat liver.
    Transplantation, 1999, Nov-27, Volume: 68, Issue:10

    Topics: Animals; Antithrombin III; Cell Hypoxia; Cells, Cultured; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glycine; Humans; Hydrogen Peroxide; Ischemia; Kupffer Cells; Leukocyte Elastase; Liver; Macrophages, Peritoneal; Male; Rats; Rats, Wistar; Reperfusion; Serine Proteinase Inhibitors; Sulfonamides; Superoxides; Transcription, Genetic

1999
Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs.
    The European respiratory journal, 1999, Volume: 14, Issue:5

    Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Glycine; Guinea Pigs; Leukocyte Elastase; Male; Oxidants, Photochemical; Ozone; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

1999
Protective effects of ONO-5046*Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury.
    The Annals of thoracic surgery, 1999, Volume: 68, Issue:6

    Topics: Animals; Cardiopulmonary Bypass; Dogs; Extravascular Lung Water; Glycine; Hemodynamics; Interleukin-6; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Lung; Oxygen; Protective Agents; Pulmonary Circulation; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance

1999
Neutrophil elastase inhibition reduces cerebral ischemic damage in the middle cerebral artery occlusion.
    Brain research, 2000, Mar-06, Volume: 858, Issue:1

    Topics: Animals; Antilymphocyte Serum; Brain Edema; Brain Ischemia; Cell Count; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glycine; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Leukocyte Elastase; Male; Neutrophils; Rats; Rats, Wistar; Rose Bengal; Serine Proteinase Inhibitors; Sulfonamides

2000
Differential modulation of annexin I binding sites on monocytes and neutrophils.
    Mediators of inflammation, 1999, Volume: 8, Issue:1

    Topics: Amino Acid Sequence; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Endopeptidases; Flow Cytometry; Glycine; Humans; In Vitro Techniques; Molecular Sequence Data; Monocytes; Neutrophils; Peptide Fragments; Peptides; Respiratory Burst; Serine Proteinase Inhibitors; Sulfonamides

1999
Neutrophil elastase inhibitor, ONO-5046 suppresses ozone-induced airway mucus hypersecretion in guinea pigs.
    European journal of pharmacology, 2000, Feb-25, Volume: 390, Issue:1-2

    Topics: Animals; Bronchoalveolar Lavage Fluid; Enzyme Inhibitors; Glycine; Glycoproteins; Guinea Pigs; In Vitro Techniques; Leukocyte Elastase; Macrophages, Alveolar; Mucus; Oxidants, Photochemical; Ozone; Respiratory Mucosa; Sulfonamides; Trachea

2000
Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.
    American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cricetinae; Disease Progression; Endotoxins; Glycine; Leukocyte Count; Leukocyte Elastase; Lung; Male; Mesocricetus; Neutrophils; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides

2000
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
    American journal of respiratory cell and molecular biology, 2000, Volume: 23, Issue:2

    Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes

2000
[Pretreatment of acid-induced lung injury with specific neutrophil elastase inhibitor ONO-5046 did not exasperate the subsequent bacterial lung infection by Pseudomonas aeruginosa].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:7

    Topics: Animals; Disease Models, Animal; Glycine; Hydrochloric Acid; Leukocyte Elastase; Male; Pneumonia, Aspiration; Pneumonia, Bacterial; Pseudomonas Infections; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides

2000
Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat.
    European journal of pharmacology, 2000, Dec-08, Volume: 409, Issue:2

    Topics: Albumins; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Glycine; Hyperoxia; Leukocyte Elastase; Lung; Lung Diseases; Neutrophils; Rats; Rats, Sprague-Dawley; Sulfonamides; Superoxide Dismutase

2000
Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.
    Journal of leukocyte biology, 2001, Volume: 69, Issue:2

    Topics: Cells, Cultured; Drug Combinations; Endothelium, Vascular; Flow Cytometry; Glycine; Glycoproteins; Humans; Interferon-gamma; Interleukin-1; Intracellular Fluid; Leukocyte Elastase; Lipopolysaccharides; Microscopy, Confocal; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Trypsin Inhibitors; Tumor Necrosis Factor-alpha; Umbilical Veins

2001
Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2001, Volume: 20, Issue:8

    Topics: Animals; Cytokines; Dogs; Glycine; Heart Transplantation; Inflammation Mediators; Leukocyte Elastase; Neutrophil Activation; Reperfusion Injury; Serine Proteinase Inhibitors; Stroke Volume; Sulfonamides; Transplantation, Heterotopic

2001
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.
    European journal of pharmacology, 2001, Aug-24, Volume: 426, Issue:1-2

    Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Catalase; Complement Activation; Cricetinae; Dose-Response Relationship, Drug; Elapid Venoms; Glycine; Leukocyte Elastase; Lung; Lung Diseases; Male; Mesocricetus; Neutrophils; Peroxidase; Proteins; Serine Proteinase Inhibitors; Sulfonamides; Time Factors

2001
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
    Journal of neurochemistry, 2001, Volume: 78, Issue:5

    Topics: Animals; Blood-Brain Barrier; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Gene Expression; Glycine; Growth Substances; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Interleukin-8; Leukocyte Elastase; Motor Activity; Peroxidase; Rats; Rats, Wistar; Recovery of Function; RNA, Messenger; Serine Proteinase Inhibitors; Spinal Cord; Spinal Cord Injuries; Sulfonamides

2001
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion.
    Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 91, Issue:4

    Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Extravascular Lung Water; Glycine; Growth Substances; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Intestines; Leukocyte Count; Leukocyte Elastase; Lung; Male; Microcirculation; Neutrophil Infiltration; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2001
Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 2

    Topics: Animals; Aspirin; Catalase; Free Radical Scavengers; Gastric Mucosa; Gerbillinae; Glycine; Helicobacter Infections; Helicobacter pylori; Leukocyte Elastase; Male; Peroxidase; Reactive Oxygen Species; Stomach Ulcer; Sulfonamides; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2002
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics.
    Critical care medicine, 2002, Volume: 30, Issue:5 Suppl

    Topics: Animals; Endothelium, Vascular; Glycine; Humans; Leukocyte Elastase; Oxidative Stress; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Xanthine Oxidase

2002
Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.
    Bioorganic & medicinal chemistry letters, 2002, Sep-02, Volume: 12, Issue:17

    Topics: Acylation; Chromatography, High Pressure Liquid; Glycine; Humans; Isoenzymes; Pancreatic Elastase; Serine Proteinase Inhibitors; Spectrometry, Mass, Electrospray Ionization; Sputum; Sulfonamides

2002
Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice.
    Shock (Augusta, Ga.), 2002, Volume: 18, Issue:2

    Topics: Analysis of Variance; Animals; Benzoates; Cytokines; Disease Models, Animal; Drug Interactions; Glycine; Injections, Intravenous; Interleukin-1; Lipopolysaccharides; Liver Circulation; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Microcirculation; Microscopy; Probability; Pyrrolidines; Random Allocation; Reference Values; Sensitivity and Specificity; Sulfonamides; Treatment Outcome; Tumor Necrosis Factor-alpha

2002
Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats.
    The European journal of surgery = Acta chirurgica, 2002, Volume: 168, Issue:8-9

    Topics: Animals; Glycine; Liver Circulation; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Reperfusion Injury; Serpins; Sulfonamides

2002
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice.
    Chest, 2003, Volume: 123, Issue:4

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Female; Glycine; Immunohistochemistry; Leukocyte Elastase; Lung Neoplasms; Mice; Mice, SCID; Sulfonamides; Tumor Cells, Cultured

2003
The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury.
    Transplant international : official journal of the European Society for Organ Transplantation, 2003, Volume: 16, Issue:5

    Topics: Animals; Cardiac Output; Female; Glycine; Leukocyte Elastase; Lung Diseases; Lung Transplantation; Oxygen; Pulmonary Circulation; Pulmonary Wedge Pressure; Rabbits; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Vascular Resistance

2003
Effect of sivelestat, an inhibitor of neutrophil elastase, on rapidly progressive glomerulonephritis.
    Clinical nephrology, 2003, Volume: 60, Issue:2

    Topics: Female; Glomerulonephritis; Glycine; Humans; Leukocyte Elastase; Middle Aged; Serine Proteinase Inhibitors; Sulfonamides

2003
Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046.
    Biochemical and biophysical research communications, 2003, Oct-03, Volume: 309, Issue:4

    Topics: Animals; Base Sequence; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Glycine; Mice; Mice, Inbred C57BL; Milk Proteins; Pancreatic Elastase; Reverse Transcriptase Polymerase Chain Reaction; STAT5 Transcription Factor; STAT6 Transcription Factor; Sulfonamides; Trans-Activators

2003
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
    European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycine; Hemorrhage; Hydrochloric Acid; In Vitro Techniques; Leukocyte Count; Leukocyte Elastase; Lung; Male; Mesocricetus; Neutrophils; Peroxidase; Pneumonia, Aspiration; Respiratory Insufficiency; Sulfonamides; Survival Analysis

2004
Hidden evidence to the West: multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals.
    Intensive care medicine, 2004, Volume: 30, Issue:5

    Topics: Anti-Inflammatory Agents; Communication Barriers; Double-Blind Method; Evidence-Based Medicine; Glycine; Humans; Japan; Methylprednisolone; Multicenter Studies as Topic; Periodicals as Topic; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome

2004
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Cephalosporins; Chemokines, CXC; Cyclooxygenase Inhibitors; Endothelium; Enzyme Inhibitors; Epoprostenol; Glycine; Iloprost; Indomethacin; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Liver; Liver Circulation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Transaminases; Vasodilator Agents

2004
[Sivelestat sodium hydrate was effective for ARDS in a patient suffering from chronic rheumatoid arthritis with acute exacerbation after failing to respond to high dose steroid pulse therapy].
    Masui. The Japanese journal of anesthesiology, 2004, Volume: 53, Issue:9

    Topics: Antigens; Antigens, Neoplasm; Arthritis, Rheumatoid; Biomarkers; Female; Glycine; Glycoproteins; Humans; Leukocyte Elastase; Methylprednisolone; Middle Aged; Mucin-1; Mucins; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein D; Pulse Therapy, Drug; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2004
[A case of Legionella pneumonia complicated with acute respiratory distress syndrome treated with methylprednisolone and sivelestat sodium in combination with intravenous erythromycin and ciprofloxacin].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2004, Volume: 42, Issue:11

    Topics: Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Erythromycin; Glycine; Humans; Infusions, Intravenous; Legionnaires' Disease; Male; Methylprednisolone; Middle Aged; Respiratory Distress Syndrome; Sulfonamides

2004
Sivelestat, a neutrophil elastase inhibitor, attenuates neutrophil priming after hepatoenteric ischemia in rabbits.
    Shock (Augusta, Ga.), 2005, Volume: 23, Issue:2

    Topics: Acetylglucosaminidase; Animals; Bronchoalveolar Lavage Fluid; Glycine; Ischemia; L-Lactate Dehydrogenase; Lactates; Leukocyte Elastase; Lipid Peroxides; Liver; Luminescent Measurements; Male; Neutrophils; Rabbits; Reperfusion Injury; Serine Proteinase Inhibitors; Stomach; Sulfonamides; Time Factors; Transaminases

2005
Cost-minimisation analysis of sivelestat for acute lung injury associated with systemic inflammatory response syndrome.
    PharmacoEconomics, 2005, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cost Savings; Female; Glycine; Health Care Costs; Humans; Male; Markov Chains; Middle Aged; Respiratory Distress Syndrome; Sulfonamides; Systemic Inflammatory Response Syndrome

2005
Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits.
    Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:4

    Topics: Acute Disease; Animals; Body Weight; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Glycine; Hemorrhage; Injections, Intravenous; Leukocyte Elastase; Lung; Male; Organ Size; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Proteins; Pulmonary Alveoli; Pulmonary Edema; Rabbits; Respiratory Insufficiency; Sulfonamides; Tetradecanoylphorbol Acetate

2005
Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation.
    The Annals of thoracic surgery, 2005, Volume: 80, Issue:2

    Topics: Actins; CD11b Antigen; Cell Adhesion Molecules; Chemotactic Factors; Chemotaxis, Leukocyte; Extracorporeal Circulation; Glycine; Humans; Inflammation Mediators; Interleukin-8; L-Selectin; Leukocyte Elastase; Models, Cardiovascular; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides

2005
Case with bromine exposure leading to respiratory insufficiency.
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2005, Volume: 18, Issue:2

    Topics: Adult; Bromine; Burns, Chemical; Burns, Inhalation; Glycine; Humans; Inhalation Exposure; Male; Methylprednisolone; Prednisolone; Pulmonary Edema; Respiration, Artificial; Respiratory Insufficiency; Sulfonamides; Volatilization

2005
Protective effects of a selective neutrophil elastase inhibitor (sivelestat) on lipopolysaccharide-induced acute dysfunction of the pulmonary microcirculation.
    Critical care medicine, 2005, Volume: 33, Issue:8

    Topics: Analysis of Variance; Animals; Cell Adhesion; Glycine; Hemodynamics; Leukocyte Elastase; Leukocytes; Lipopolysaccharides; Male; Microcirculation; Microscopy, Polarization; Microscopy, Video; Microspectrophotometry; Pulmonary Circulation; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides

2005
Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients.
    The Tohoku journal of experimental medicine, 2005, Volume: 207, Issue:2

    Topics: Aged; Aged, 80 and over; Critical Illness; Female; Glycine; Hospitals, University; Hospitals, Urban; Humans; Intensive Care Units; Japan; Length of Stay; Leukocyte Elastase; Male; Middle Aged; Multiple Organ Failure; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Treatment Outcome

2005
[Clinical experience of sivelestat sodium hydrate for severe reexpansion pulmonary edema; report of a case].
    Kyobu geka. The Japanese journal of thoracic surgery, 2005, Volume: 58, Issue:11

    Topics: Aged; Aged, 80 and over; Drainage; Glycine; Humans; Male; Methylprednisolone; Pneumothorax; Pulmonary Edema; Pulse Therapy, Drug; Respiration, Artificial; Serine Proteinase Inhibitors; Sulfonamides

2005
Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats.
    Inflammation, 2004, Volume: 28, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Glycine; Granulocyte Colony-Stimulating Factor; Hydrochloric Acid; Leukocyte Elastase; Lung; Lung Injury; Male; Pneumonia, Aspiration; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors

2004
Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome.
    Journal of anesthesia, 2006, Volume: 20, Issue:1

    Topics: Aged; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome

2006
Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2005, Volume: 41, Issue:5

    Topics: Animals; Bronchi; Glycine; Guinea Pigs; In Vitro Techniques; Indomethacin; Leukocyte Elastase; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Prostaglandins; Respiratory Mucosa; Respiratory System; Serine Proteinase Inhibitors; Substance P; Sulfonamides; Tachykinins; Trachea

2005
[Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2006, Volume: 44, Issue:1

    Topics: Acute Disease; Aged; Drug Therapy, Combination; Female; Glycine; Humans; Lung Diseases, Interstitial; Male; Methylprednisolone; Middle Aged; Prednisolone; Respiratory Insufficiency; Serine Proteinase Inhibitors; Sulfonamides

2006
ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor, phosphorylated extracellular signal-regulated kinase, and caspase3 after spinal cord ischemia in rabbits.
    The Journal of thoracic and cardiovascular surgery, 2006, Volume: 131, Issue:3

    Topics: Animals; Brain-Derived Neurotrophic Factor; Caspase 3; Caspases; Cell Death; Extracellular Signal-Regulated MAP Kinases; Glycine; Leukocyte Elastase; Male; Motor Neurons; Phosphorylation; Rabbits; Spinal Cord Ischemia; Sulfonamides; Time Factors

2006
Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.
    Journal of anesthesia, 2006, Volume: 20, Issue:2

    Topics: Animals; Blood Gas Analysis; Cytokines; Glycine; Lung; Lung Diseases; Male; Pancreatic Elastase; Protease Inhibitors; Rats; Rats, Wistar; Respiration, Artificial; Sulfonamides; Tidal Volume

2006
Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.
    Journal of gastroenterology, 2006, Volume: 41, Issue:4

    Topics: Adult; Animals; Biomarkers; Cells, Cultured; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Glycine; Humans; Intestinal Mucosa; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides

2006
Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters.
    Shock (Augusta, Ga.), 2006, Volume: 26, Issue:1

    Topics: Acute Disease; Animals; Cricetinae; Glycine; Leukocyte Elastase; Lipopolysaccharides; Male; Microcirculation; Pneumonia; Pulmonary Alveoli; Pulmonary Circulation; Serine Proteinase Inhibitors; Sulfonamides

2006
Application of chemical arrays in screening elastase inhibitors.
    Combinatorial chemistry & high throughput screening, 2006, Volume: 9, Issue:5

    Topics: Bromphenol Blue; Catalytic Domain; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Glycine; Kinetics; Pancreatic Elastase; Protein Array Analysis; Sensitivity and Specificity; Substrate Specificity; Sulfonamides

2006
Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.
    Journal of anesthesia, 2006, Volume: 20, Issue:3

    Topics: Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Endotoxins; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Glycine; Humans; In Vitro Techniques; Interleukin-8; Polymerase Chain Reaction; Pulmonary Alveoli; Respiratory Mucosa; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha

2006
[Prophylactic effects of neutrophil elastase inhibitor for patients undergoing surgery for thoracic aortic aneurysm: a retrospective study].
    Masui. The Japanese journal of anesthesiology, 2006, Volume: 55, Issue:8

    Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Thoracic; Cardiopulmonary Bypass; Female; Glycine; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Proteins; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Systemic Inflammatory Response Syndrome

2006
Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha.
    Cancer science, 2006, Volume: 97, Issue:10

    Topics: Animals; Carcinoma; ErbB Receptors; Female; Glycine; Humans; Leukocyte Elastase; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 3; Neoplasm Transplantation; Phosphorylation; Serine Proteinase Inhibitors; Stomach Neoplasms; Sulfonamides; Transforming Growth Factor alpha; Xenograft Model Antitumor Assays

2006
Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases.
    European journal of haematology, 2006, Volume: 77, Issue:5

    Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytoprotection; Dexamethasone; Female; Glycine; Humans; Intracranial Hemorrhages; Leukemia, Promyelocytic, Acute; Male; Prospective Studies; Radiography; Randomized Controlled Trials as Topic; Remission Induction; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tretinoin

2006
The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection.
    The Thoracic and cardiovascular surgeon, 2006, Volume: 54, Issue:6

    Topics: Acute Disease; Aged; Aortic Aneurysm; Aortic Dissection; Cardiopulmonary Bypass; Female; Glycine; Humans; Male; Postoperative Care; Proteinase Inhibitory Proteins, Secretory; Respiratory Insufficiency; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides

2006
Benefical effect of neutrophil elastase inhibitor on renal warm ischemia-reperfusion injury in the rat.
    Transplantation proceedings, 2006, Volume: 38, Issue:7

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Functional Laterality; Glycine; Leukocyte Elastase; Male; Rats; Rats, Inbred Lew; Renal Artery; Renal Circulation; Renal Veins; Reperfusion Injury; Sulfonamides; Survival Analysis

2006
ICAM-1 signal transduction in cells stimulated with neutrophil elastase.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:11

    Topics: alpha 1-Antitrypsin; Animals; Blotting, Northern; Dose-Response Relationship, Drug; Endothelial Cells; Glycine; Immunohistochemistry; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Male; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Sulfonamides

2006
Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate.
    Internal medicine (Tokyo, Japan), 2006, Volume: 45, Issue:18

    Topics: Antitubercular Agents; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Tuberculosis, Miliary

2006
Usefulness of sivelestat sodium administration in patients with aspiration pneumonia.
    Journal of anesthesia, 2006, Volume: 20, Issue:4

    Topics: Anti-Bacterial Agents; C-Reactive Protein; Child; Child, Preschool; Glycine; Humans; Leukocyte Elastase; Leukocytes; Male; Meropenem; Middle Aged; Pneumonia, Aspiration; Radiography; Serine Proteinase Inhibitors; Sulfonamides; Thienamycins

2006
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).
    Internal medicine (Tokyo, Japan), 2006, Volume: 45, Issue:20

    Topics: Acute Kidney Injury; Adult; Antibodies, Viral; Bronchi; Carcinoma; Combined Modality Therapy; Female; gamma-Globulins; Glycine; Granulocyte Colony-Stimulating Factor; Humans; Immunocompromised Host; Immunosuppressive Agents; Influenza A Virus, H3N2 Subtype; Influenza, Human; Lymphohistiocytosis, Hemophagocytic; Methylprednisolone; Myocarditis; Postoperative Complications; Respiration, Artificial; Respiratory Insufficiency; Sulfonamides; Tongue Neoplasms

2006
Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines.
    Oncology reports, 2007, Volume: 17, Issue:1

    Topics: Cell Growth Processes; Cell Line, Tumor; Cell Movement; ErbB Receptors; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Glycine; Humans; Leukocyte Elastase; MAP Kinase Signaling System; Platelet-Derived Growth Factor; Sulfonamides; Transforming Growth Factor alpha; Vascular Endothelial Growth Factor A

2007
[Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2006, Volume: 80, Issue:6

    Topics: Adult; Alcoholism; Feeding and Eating Disorders; Female; Glycine; Humans; Leukocyte Elastase; Malnutrition; Pneumonia, Pneumococcal; Respiratory Distress Syndrome; Sulfonamides

2006
Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model.
    The Annals of thoracic surgery, 2007, Volume: 83, Issue:1

    Topics: Animals; Cardiopulmonary Bypass; Glycine; Interleukin-8; Leukocyte Elastase; Lipopolysaccharides; Neutrophils; Peroxidase; Rabbits; Respiratory Distress Syndrome; Sulfonamides

2007
Invited commentary.
    The Annals of thoracic surgery, 2007, Volume: 83, Issue:1

    Topics: Animals; Cardiopulmonary Bypass; Glycine; Leukocyte Elastase; Lipopolysaccharides; Rabbits; Respiratory Distress Syndrome; Sulfonamides

2007
A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.
    International journal of molecular medicine, 2007, Volume: 19, Issue:2

    Topics: Animals; DNA; Gene Expression Regulation; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lung; Lung Injury; Male; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Protein Binding; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Sulfonamides; Tumor Necrosis Factor-alpha

2007
[A case of idiopathic ARDS treated by sivelestat sodium and fluid management based on extravascular lung water index].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2006, Volume: 44, Issue:12

    Topics: Aged; Extravascular Lung Water; Female; Fluid Therapy; Glycine; Humans; Leukocyte Elastase; Respiration, Artificial; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides

2006
Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy.
    The British journal of surgery, 2007, Volume: 94, Issue:5

    Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Glycine; Hepatectomy; Humans; Leukocyte Elastase; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides

2007
Sivelestat reduces reperfusion injury of lungs harvested from endotoxin-primed rats by inhibition of neutrophil-mediated inflammation.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:4

    Topics: Animals; Cytokines; Endotoxins; Escherichia coli; Glycine; Injections, Intraperitoneal; Interleukin-8; Leukocyte Elastase; Lung; Lung Transplantation; Male; Neutrophils; Pneumonia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Tissue and Organ Harvesting; Tumor Necrosis Factor-alpha

2007
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia.
    Experimental lung research, 2007, Volume: 33, Issue:2

    Topics: Animals; Blood; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Female; Glycine; Leukocyte Elastase; Lung; Mice; Mice, Inbred CBA; Pneumonia, Pneumococcal; Serine Proteinase Inhibitors; Streptococcus pneumoniae; Sulfonamides; Survival Rate

2007
Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
    British journal of pharmacology, 2007, Volume: 151, Issue:5

    Topics: Animals; Basement Membrane; Bone Marrow Cells; Cell Movement; Chemotaxis, Leukocyte; Enzyme Inhibitors; Glycine; Leukocyte Elastase; Leukotriene B4; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neutrophils; Platelet Activating Factor; Sulfonamides; Venules

2007
Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits.
    Shock (Augusta, Ga.), 2007, Volume: 28, Issue:1

    Topics: Acute Disease; Animals; Glycine; HMGB1 Protein; Hypoxia; Intestinal Mucosa; Leukocyte Elastase; Male; Neutrophils; Permeability; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rabbits; Sulfonamides

2007
[A case of legionella pneumonia associated with acute respiratory distress syndrome (ARDS) and acute renal failure treated with methylprednisolone and sivelestat].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2007, Volume: 45, Issue:5

    Topics: Acute Kidney Injury; Glucocorticoids; Glycine; Humans; Legionnaires' Disease; Male; Methylprednisolone; Middle Aged; Respiratory Distress Syndrome; Sulfonamides

2007
Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice.
    European journal of pharmacology, 2007, Sep-24, Volume: 571, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Chemokines, CXC; Enzyme-Linked Immunosorbent Assay; Glycine; Injections, Intraperitoneal; Interleukin-6; Leukocyte Elastase; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neutrophil Infiltration; Neutrophils; Pulmonary Edema; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha; Ventilators, Mechanical

2007
[Outcome of patients with acute exacerbation of idiopathic interstitial fibrosis (IPF) treated with sivelestat and the prognostic value of serum KL-6 and surfactant protein D].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2007, Volume: 45, Issue:6

    Topics: Acute Disease; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers; Chronic Disease; Disease Progression; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Mucin-1; Mucins; Pulmonary Fibrosis; Pulmonary Surfactant-Associated Protein D; Respiratory Insufficiency; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2007
[Good response in ARDS treated with sivelestat sodium hydrate during chemotherapy for cholangiocarcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Drug Administration Schedule; Drug Combinations; Glycine; Humans; Male; Neutropenia; Oxonic Acid; Paclitaxel; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Tegafur

2007
Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2007, Volume: 32, Issue:5

    Topics: Animals; Glycine; Leukocyte Elastase; Lung; Lung Transplantation; Male; Models, Animal; Organ Preservation; Organ Preservation Solutions; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2007
Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase.
    Biochemical and biophysical research communications, 2007, Dec-14, Volume: 364, Issue:2

    Topics: Animals; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Fibroblast Growth Factor 2; Glycine; Humans; In Vitro Techniques; Leukocyte Elastase; Mice; Neovascularization, Physiologic; Sulfonamides; Vascular Endothelial Growth Factor A

2007
Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2007, Volume: 20, Issue:6

    Topics: Aged; Combined Modality Therapy; Enzyme Inhibitors; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Postoperative Period; Sulfonamides; Treatment Outcome

2007
[Case of fulminant idiopathic interstitial pneumonia treated by sodium siverlestat (Elaspol) and steroid pulse therapy following extracorporeal lung assist (ECLA)].
    Masui. The Japanese journal of anesthesiology, 2007, Volume: 56, Issue:10

    Topics: Extracorporeal Membrane Oxygenation; Glycine; Humans; Lung Diseases, Interstitial; Male; Methylprednisolone; Middle Aged; Pulse Therapy, Drug; Sulfonamides; Treatment Outcome

2007
Effects of sivelestat sodium hydrate on the reduction of radiation pneumonitis.
    International journal of molecular medicine, 2007, Volume: 20, Issue:6

    Topics: Animals; Female; Glycine; Leukocyte Elastase; Lung; Mice; Mice, Inbred C57BL; Radiation Pneumonitis; Serine Proteinase Inhibitors; Sulfonamides

2007
Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.
    Molecular and cellular biochemistry, 2008, Volume: 311, Issue:1-2

    Topics: Animals; Glycine; Leukocyte Elastase; Male; Malondialdehyde; Nitrates; Nitrites; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Sulfonamides; Urinary Bladder

2008
Beneficial effect of neutrophil elastase inhibitor on anti-Thy1.1 nephritis in rats.
    Nephrology (Carlton, Vic.), 2008, Volume: 13, Issue:1

    Topics: Animals; Disease Models, Animal; Glycine; Kidney Glomerulus; Male; Microscopy, Electron; Microscopy, Fluorescence; Nephritis; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Thy-1 Antigens; Treatment Outcome

2008
Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:7

    Topics: Animals; Consciousness; Gastrointestinal Motility; Glycine; Guinea Pigs; Hypotension; Infusions, Intravenous; Intestinal Diseases; Lipopolysaccharides; Male; Sulfonamides

2008
Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Aspartate Aminotransferases; Blood Pressure; Cell Line; Enzyme Inhibitors; Glycine; Heart Rate; Hepatectomy; Hepatocytes; In Situ Nick-End Labeling; In Vitro Techniques; Leukocyte Elastase; Lipopolysaccharides; Liver Diseases; Nitric Oxide Synthase Type II; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Sulfonamides; Swine; Tumor Necrosis Factor-alpha

2008
[A case of lung adenocarcinoma effectively treated with sivelestat and corcicosteroid for drug-induced lung disease due to gefitinib].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2008, Volume: 46, Issue:3

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Gefitinib; Glycine; Humans; Lung Diseases; Lung Neoplasms; Male; Prednisolone; Quinazolines; Serine Proteinase Inhibitors; Sulfonamides

2008
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
    Respirology (Carlton, Vic.), 2008, Volume: 13, Issue:4

    Topics: Aged; alpha 1-Antitrypsin; Enzyme Inhibitors; Female; Glycine; Humans; Leukocyte Elastase; Male; Middle Aged; Respiratory Distress Syndrome; Sulfonamides

2008
[Case of severe transfusion-related acute lung injury during coronary artery bypass surgery].
    Masui. The Japanese journal of anesthesiology, 2008, Volume: 57, Issue:4

    Topics: Aged; Angina Pectoris; Antibodies; Coronary Artery Bypass; Glycine; Granulocytes; HLA Antigens; Humans; Intraoperative Complications; Male; Respiratory Distress Syndrome; Severity of Illness Index; Sulfonamides; Transfusion Reaction

2008
Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat.
    Internal medicine (Tokyo, Japan), 2008, Volume: 47, Issue:8

    Topics: Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Erythromycin; Fluoroquinolones; Glycine; Humans; Legionnaires' Disease; Male; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2008
Sivelestat relaxes porcine coronary artery via inhibition of Ca2+ sensitization induced by a receptor agonist.
    Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium; Coronary Vessels; Endothelium, Vascular; Glycine; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Sulfonamides; Swine; Vasoconstrictor Agents; Vasodilator Agents

2008
Sivelestat and its role in tissue reperfusion injury.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 33, Issue:6

    Topics: Glycine; Humans; Leukocyte Elastase; Lung; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2008
A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
    Inflammation, 2008, Volume: 31, Issue:4

    Topics: Animals; Glycine; HMGB1 Protein; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Lung; Lung Injury; Male; NF-kappa B; Nitrates; Nitrites; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Shock, Septic; Sulfonamides; Tumor Necrosis Factor-alpha

2008
[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2008, Volume: 46, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; Drug Therapy, Combination; Ganciclovir; Glycine; Humans; Male; Methylprednisolone; Pneumonia, Pneumocystis; Proteinase Inhibitory Proteins, Secretory; Pulse Therapy, Drug; Respiratory Insufficiency; Severity of Illness Index; Sulfonamides; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination

2008
The effect of sivelestat sodium on post-cardiopulmonary bypass acute lung injury in a neonatal piglet model.
    Interactive cardiovascular and thoracic surgery, 2008, Volume: 7, Issue:5

    Topics: Animals; Animals, Newborn; Cardiopulmonary Bypass; Disease Models, Animal; Drug Administration Schedule; Glycine; Leukocyte Elastase; Lung; Lung Diseases; Neutrophil Activation; Neutrophils; Serine Proteinase Inhibitors; Sulfonamides; Swine; Time Factors

2008
Successful management of postoperative acute respiratory distress syndrome in a patient with lung cancer.
    General thoracic and cardiovascular surgery, 2008, Volume: 56, Issue:7

    Topics: Adrenal Cortex Hormones; Aged; Drug Therapy, Combination; Glycine; Humans; Lung Neoplasms; Male; Pneumonectomy; Proteinase Inhibitory Proteins, Secretory; Radiography, Thoracic; Respiratory Distress Syndrome; Sulfonamides; Tomography, X-Ray Computed; Treatment Outcome

2008
Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study.
    The Journal of cardiovascular surgery, 2008, Volume: 49, Issue:5

    Topics: Acute Disease; Analysis of Variance; Aortic Aneurysm, Thoracic; Aortic Dissection; Cardiopulmonary Bypass; Chi-Square Distribution; Female; Glycine; Humans; Leukocyte Count; Lung Diseases; Male; Pilot Projects; Postoperative Complications; Respiratory Function Tests; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2008
Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:4

    Topics: Aged; Aged, 80 and over; Aorta, Thoracic; Aortic Aneurysm; Blood Vessel Prosthesis Implantation; C-Reactive Protein; Cardiopulmonary Bypass; Female; Glycine; Hemodynamics; Humans; Hypothermia, Induced; Lung Diseases; Male; Middle Aged; Oxygen; Oxygen Consumption; Partial Pressure; Postoperative Complications; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2008
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:6

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Colony Count, Microbial; Cricetinae; Disease Models, Animal; Glycine; Leukocyte Elastase; Mesocricetus; Pneumonia, Pneumococcal; Proteinase Inhibitory Proteins, Secretory; Pulmonary Surfactant-Associated Protein D; Streptococcus pneumoniae; Sulfonamides; Time Factors

2008
A neutrophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardiopulmonary bypass.
    Journal of anesthesia, 2008, Volume: 22, Issue:4

    Topics: Anesthesia, Inhalation; Cardiopulmonary Bypass; Female; Glycine; Heart; Heart Septal Defects, Ventricular; Hematocrit; Humans; Hypertension, Pulmonary; Infant; Intensive Care Units, Pediatric; Leukocyte Count; Male; Oxygen; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Respiratory Mechanics; Retrospective Studies; Sulfonamides; Vascular Surgical Procedures; Ventricular Function, Left

2008
[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2008, Volume: 46, Issue:10

    Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Leukocyte Elastase; Male; Pneumonia, Bacterial; Retrospective Studies; Serine Proteinase Inhibitors; Severity of Illness Index; Sulfonamides; Systemic Inflammatory Response Syndrome

2008
Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.
    Brain research, 2009, Mar-09, Volume: 1259

    Topics: Animals; Brain; Brain Ischemia; Caspase 3; Caspase 7; Cell Survival; Endothelium; Extracellular Space; Glycine; Leukocyte Elastase; Male; Neurons; Neuroprotective Agents; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Wistar; Reperfusion; Sulfonamides; Time Factors

2009
Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009, Volume: 58, Issue:4

    Topics: Animals; Cell Line; Cytokines; Glycine; HMGB1 Protein; Leukocyte Elastase; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides

2009
Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia.
    Interactive cardiovascular and thoracic surgery, 2009, Volume: 8, Issue:6

    Topics: Acetylcholine; Animals; Cardiotonic Agents; Coronary Circulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Glycine; In Vitro Techniques; Leukocyte Elastase; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Troponin T; Vasodilator Agents; Ventricular Function, Left; Ventricular Pressure

2009
Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury.
    Interactive cardiovascular and thoracic surgery, 2009, Volume: 8, Issue:6

    Topics: Animals; Apoptosis; Disease Models, Animal; Glycine; Infusions, Intra-Arterial; Leukocyte Elastase; Motor Activity; Motor Neurons; Neuroprotective Agents; Paraplegia; Rabbits; Serine Proteinase Inhibitors; Spinal Cord Injuries; Spinal Cord Ischemia; Sulfonamides

2009
Sivelestat treatment for acute respiratory distress syndrome in an infant.
    Journal of anesthesia, 2009, Volume: 23, Issue:2

    Topics: Anti-Inflammatory Agents; C-Reactive Protein; Cardiopulmonary Resuscitation; Glycine; Humans; Hypoxia, Brain; Immunosuppressive Agents; Infant; Leukocyte Count; Leukocyte Elastase; Male; Oxygen; Positive-Pressure Respiration; Protein Kinase Inhibitors; Radiography; Respiratory Distress Syndrome; Sulfonamides

2009
Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion.
    The Journal of surgical research, 2009, Volume: 155, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Glycine; Leukocytes; Lipid Peroxidation; Liver; Male; Microcirculation; Models, Animal; Pancreatic Elastase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2009
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:1

    Topics: Adult; Aged; Disseminated Intravascular Coagulation; Female; Glycine; Humans; Male; Middle Aged; Respiratory Distress Syndrome; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2010
Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:5

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cecum; Disease Models, Animal; Glycine; HMGB1 Protein; Inflammation; Interleukin-8; Ligation; Lung; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides; Survival Analysis

2010
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.
    Experimental lung research, 2009, Volume: 35, Issue:10

    Topics: Animals; Apoptosis; Bleomycin; Bronchoalveolar Lavage Fluid; Caspase 3; Caspase 9; Cell Line; Chemotaxis, Leukocyte; Cytokines; Epithelial Cells; Glycine; Humans; Hydroxyproline; Leukocyte Elastase; Lung; Male; Neutrophils; Poly(ADP-ribose) Polymerases; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides

2009
The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
    The Journal of trauma, 2010, Volume: 68, Issue:4

    Topics: Acute Lung Injury; Adult; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dehydroascorbic Acid; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Female; Glycine; Humans; Male; Middle Aged; Oxidative Stress; Point-of-Care Systems; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2010
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury.
    Transplantation, 2010, May-15, Volume: 89, Issue:9

    Topics: Animals; Chemokine CXCL1; DNA Primers; Glycine; Humans; Immunohistochemistry; Inflammation; Interleukin-6; Leukocyte Elastase; Liver; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Polymerase Chain Reaction; Proteinase Inhibitory Proteins, Secretory; Reperfusion Injury; RNA; Sulfonamides; Tumor Necrosis Factor-alpha

2010
Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus.
    Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:5

    Topics: Acute Lung Injury; Adult; Antiviral Agents; Female; Glycine; Hemorrhage; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung Diseases; Oseltamivir; Sulfonamides; Treatment Outcome

2010
Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion.
    Platelets, 2010, Volume: 21, Issue:4

    Topics: Animals; Blood Platelets; Cytokines; Glycine; Liver; Liver Circulation; Liver Diseases; Male; Neutrophils; Platelet Adhesiveness; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2010
Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection.
    The Thoracic and cardiovascular surgeon, 2010, Volume: 58, Issue:3

    Topics: Acute Disease; Aged; Antithrombin III; Aortic Aneurysm; Aortic Dissection; Blood Vessel Prosthesis Implantation; C-Reactive Protein; Female; Glycine; Humans; Infusions, Intravenous; International Normalized Ratio; Leukocyte Count; Leukocyte Elastase; Lung; Male; Middle Aged; Partial Thromboplastin Time; Platelet Count; Postoperative Hemorrhage; Prothrombin Time; Respiratory Function Tests; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome

2010
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.
    Journal of anesthesia, 2010, Volume: 24, Issue:4

    Topics: Animals; Coronary Circulation; Female; Glycine; Interleukin-6; Male; Myocardial Ischemia; Myocardial Stunning; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Swine

2010
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
    Translational research : the journal of laboratory and clinical medicine, 2010, Volume: 155, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Cephalosporins; Glycine; Hepatic Artery; Iloprost; Indomethacin; Insulin-Like Growth Factor I; Leukocyte Elastase; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Peroxidase; Platelet Aggregation Inhibitors; Portal Vein; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides

2010
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:7

    Topics: Acute Disease; Angiopoietin-1; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cells, Cultured; Glycine; Humans; Hypoxia-Ischemia, Brain; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Microvessels; Proteinase Inhibitory Proteins, Secretory; Sulfonamides

2010
Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
    European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3

    Topics: Animals; Bronchoalveolar Lavage Fluid; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Gabexate; Glycine; Hydrochloric Acid; Leukocyte Count; Lung Injury; Male; Neutrophils; Protease Inhibitors; Proteinase Inhibitory Proteins, Secretory; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium; Sulfonamides

2010
Protective effect of sivelestat, a neutrophil elastase inhibitor, on ipsilateral and contralateral testes after unilateral testicular ischaemia-reperfusion injury in rats.
    BJU international, 2011, Volume: 107, Issue:2

    Topics: Animals; Glycine; HSP70 Heat-Shock Proteins; Male; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfonamides; Testis; Testosterone

2011
Neutrophil elastase contributes to acute lung injury induced by bilateral nephrectomy.
    The American journal of pathology, 2010, Volume: 177, Issue:4

    Topics: Acute Lung Injury; Animals; Blotting, Western; Chemokines; Glycine; Interleukin-6; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Nephrectomy; Neutrophil Activation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate; Tumor Necrosis Factor-alpha

2010
Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.
    International journal of dermatology, 2010, Volume: 49, Issue:9

    Topics: Cell Line; Cell Proliferation; Glycine; Humans; Ki-67 Antigen; Leukocyte Elastase; Organ Culture Techniques; Psoriasis; Sulfonamides; Tumor Suppressor Protein p53; Up-Regulation

2010
In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
    Experimental lung research, 2010, Volume: 36, Issue:8

    Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Therapy, Combination; Fluoroquinolones; Glycine; Legionella pneumophila; Legionnaires' Disease; Leukocyte Elastase; Longevity; Lung; Male; Mice; Mice, Inbred Strains; Oxazines; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2010
Neutrophil elastase inhibitor restores gut ischemia reperfusion-induced impairment of gut immunity with reduced plasma interleukin-6 concentrations in mice.
    Surgical infections, 2010, Volume: 11, Issue:6

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Gastrointestinal Tract; Glycine; Interleukin-6; Intestinal Mucosa; Ischemia; Leukocyte Elastase; Lymphocyte Count; Lymphocyte Subsets; Male; Mice; Mice, Inbred ICR; Reperfusion; Sulfonamides; Survival Analysis

2010
Suppressive effects of sivelestat on interleukin 8 and TNF-α production from LPS-stimulated granulocytes in whole blood culture.
    Journal of anesthesia, 2010, Volume: 24, Issue:6

    Topics: Acute Lung Injury; Flow Cytometry; Glycine; Granulocytes; Humans; In Vitro Techniques; Interleukin-8; Lipopolysaccharides; Monocytes; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Tumor Necrosis Factor-alpha

2010
A survey of the effects of sivelestat sodium administration on patients with postoperative respiratory dysfunction.
    Surgery today, 2010, Volume: 40, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Female; Glycine; Health Status; Health Surveys; Humans; Inflammation; Japan; Lung Diseases; Male; Middle Aged; Postoperative Complications; Risk Factors; Serine Proteinase Inhibitors; Stress, Psychological; Sulfonamides; Systemic Inflammatory Response Syndrome

2010
Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:6

    Topics: Animals; Cells, Cultured; Cytokines; Gene Expression Regulation, Enzymologic; Glycine; Hepatocytes; Male; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Serine Proteinase Inhibitors; Sulfonamides

2011
The effects of sivelestat sodium hydrate on uterine contraction and the concentration of maternal and fetal blood cytokines in a sheep model of intra-amniotic infection induced by lipopolysaccharide.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:8

    Topics: Animals; Chorioamnionitis; Cytokines; Dinoprostone; Disease Models, Animal; Female; Fetal Blood; Glycine; Lipopolysaccharides; Obstetric Labor, Premature; Pregnancy; Random Allocation; Serine Proteinase Inhibitors; Sheep; Sulfonamides; Uterine Contraction

2011
Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration.
    Shock (Augusta, Ga.), 2011, Volume: 36, Issue:3

    Topics: Acute Lung Injury; Aged; Aged, 80 and over; Female; Glycine; Humans; Laryngopharyngeal Reflux; Male; Middle Aged; Prospective Studies; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; Time Factors; Treatment Outcome

2011
Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.
    Journal of physiology and biochemistry, 2011, Volume: 67, Issue:4

    Topics: Aged; Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Hemodynamics; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Stomach; Sulfonamides; Vasoconstriction; Vasodilation; Vasodilator Agents

2011
AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Dogs; Dose-Response Relationship, Drug; Emphysema; Female; Glycine; Guinea Pigs; Humans; Kinetics; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Oxadiazoles; Pneumonia; Protein Binding; Pyridones; Pyrimidinones; Rats; Serine Proteinase Inhibitors; Species Specificity; Substrate Specificity; Sulfonamides; Sulfones; Swine; Tobacco Smoke Pollution

2011
Recent advancements of total aortic arch replacement.
    The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:1

    Topics: Aged; Aged, 80 and over; Anastomosis, Surgical; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Vessel Prosthesis Implantation; Body Temperature Regulation; Cardiopulmonary Bypass; Chi-Square Distribution; Emergency Treatment; Female; Glycine; Hospital Mortality; Humans; Male; Postoperative Complications; Retrospective Studies; Risk Factors; Serine Proteinase Inhibitors; Sternotomy; Sulfonamides; Survival Rate; Treatment Outcome

2012
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.
    Experimental lung research, 2012, Volume: 38, Issue:1

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Collagen; Glycine; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; Respiratory Distress Syndrome; Serine Proteinase Inhibitors; Smad2 Protein; Smad3 Protein; Sulfonamides; Transforming Growth Factor beta1

2012
The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer.
    Surgery today, 2012, Volume: 42, Issue:7

    Topics: Acute Lung Injury; Aged; C-Reactive Protein; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Inflammation; Length of Stay; Male; Middle Aged; Oxygen; Perioperative Period; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sulfonamides; Survival Rate

2012
Inhaled neutrophil elastase inhibitor reduces oleic acid-induced acute lung injury in rats.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:1

    Topics: Acute Lung Injury; Administration, Inhalation; Albumins; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cell Count; Extravascular Lung Water; Female; Glycine; Injections, Intravenous; Leukocyte Count; Leukocyte Elastase; Oleic Acid; Ovalbumin; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Survival Analysis

2012
Growth effect of neutrophil elastase on breast cancer: favorable action of sivelestat and application to anti-HER2 therapy.
    Anticancer research, 2012, Volume: 32, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glycine; Humans; Leukocyte Elastase; Receptor, ErbB-2; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides; Transforming Growth Factor alpha; Trastuzumab

2012
Effects of phorbol myristate acetate and sivelestat on the lung injury caused by fat embolism in isolated lungs.
    Journal of biomedical science, 2012, Jan-05, Volume: 19

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Embolism, Fat; Glycine; In Vitro Techniques; Inflammation Mediators; Leukocyte Elastase; Lung; Male; Neutrophil Activation; Neutrophils; Pulmonary Embolism; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate

2012
Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9.
    Journal of leukocyte biology, 2012, Volume: 91, Issue:4

    Topics: Acetylcysteine; Adult; Animals; Antigens, CD; Cell Line; CHO Cells; Cricetinae; Cricetulus; Female; Free Radical Scavengers; Glycine; Humans; Immune Evasion; Immunity, Innate; Lectins; Leukosialin; Male; Neutrophils; Phagocytosis; Pseudomonas aeruginosa; Pseudomonas Infections; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sialic Acid Binding Immunoglobulin-like Lectins; Sulfonamides

2012
Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2012, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Animals; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Glycine; Glycoproteins; Humans; Interferon-beta; Male; Mice; Mice, Inbred C57BL; Middle Aged; Myelin-Oligodendrocyte Glycoprotein; Neuromyelitis Optica; Pancreatic Elastase; Peptide Fragments; Serine Proteinase Inhibitors; Sulfonamides; Th1 Cells; Th17 Cells; Young Adult

2012
A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice.
    The European respiratory journal, 2012, Volume: 40, Issue:6

    Topics: Animals; Bleomycin; Bronchoalveolar Lavage; Collagen; Fibrosis; Glycine; Inflammation; Leukocyte Elastase; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Pulmonary Fibrosis; Serine Proteinase Inhibitors; Smad2 Protein; Sulfonamides; Time Factors; Transforming Growth Factor beta1

2012
Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012, Volume: 61, Issue:6

    Topics: Acute Lung Injury; Animals; Antipyrine; Drug Combinations; Edaravone; Free Radical Scavengers; Glycine; Interleukin-6; Lipopolysaccharides; Male; Malondialdehyde; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Necrosis Factor-alpha

2012
Direct interaction of ONO-5046 with human neutrophil elastase through ¹H NMR and molecular docking.
    International journal of biological macromolecules, 2012, Volume: 51, Issue:3

    Topics: Glycine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Leukocyte Elastase; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Sulfonamides

2012
Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
    The Journal of surgical research, 2013, Volume: 180, Issue:1

    Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Constriction; Glycine; Intestines; Male; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate

2013
Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women.
    Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:6

    Topics: Adult; Amniotic Fluid; Female; Fetal Membranes, Premature Rupture; Glycine; Humans; Injections, Intravenous; Interleukin-6; Interleukin-8; Magnesium Sulfate; Obstetric Labor, Premature; Pregnancy; Ritodrine; Serine Proteinase Inhibitors; Sulfonamides; Tocolytic Agents; Young Adult

2012
CXC receptor 1 and 2 and neutrophil elastase inhibitors alter radiation-induced lung disease in the mouse.
    International journal of radiation oncology, biology, physics, 2013, Jan-01, Volume: 85, Issue:1

    Topics: Animals; Female; Glycine; Male; Mice; Neutrophils; Proteinase Inhibitory Proteins, Secretory; Radiation Injuries, Experimental; Radiation Pneumonitis; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Sex Factors; Sulfonamides

2013
Role of neutrophil elastase in lung injury induced by burn-blast combined injury in rats.
    Burns : journal of the International Society for Burn Injuries, 2013, Volume: 39, Issue:4

    Topics: Animals; Blast Injuries; Bronchoalveolar Lavage Fluid; Burns; Carbon Dioxide; Disease Models, Animal; Glycine; Interleukin-8; Leukocyte Elastase; Lung Injury; Male; Oxygen; Partial Pressure; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha

2013
Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats.
    Experimental lung research, 2012, Volume: 38, Issue:9-10

    Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Glycine; Lung; Lung Injury; Male; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides

2012
Clinical evaluation of sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis.
    Drug design, development and therapy, 2012, Volume: 6

    Topics: Abdomen; Acute Lung Injury; Aged; Female; Glycine; Humans; Male; Middle Aged; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiratory Distress Syndrome; Sepsis; Sulfonamides; Ventilator Weaning

2012
Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats.
    Shock (Augusta, Ga.), 2013, Volume: 39, Issue:1

    Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Dioxide; Combined Modality Therapy; Crush Syndrome; Drug Evaluation, Preclinical; Fluid Therapy; Glycine; HMGB1 Protein; Liver; Lung; Male; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhabdomyolysis; Serine Proteinase Inhibitors; Sulfonamides; Survival Analysis; Treatment Outcome

2013
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses.
    Respiratory research, 2013, Jan-24, Volume: 14

    Topics: Allergens; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines; Cytokines; Female; Flow Cytometry; Glycine; Immunohistochemistry; Inflammation; Intercellular Signaling Peptides and Proteins; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ovalbumin; Proteinase Inhibitory Proteins, Secretory; Receptor, PAR-2; Respiratory Hypersensitivity; Sulfonamides

2013
Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
    Molecular medicine reports, 2013, Volume: 7, Issue:4

    Topics: Abnormalities, Radiation-Induced; Animals; Glycine; Humans; Inflammation; Leukocyte Elastase; Lung; Lung Injury; Mice; Radiation-Protective Agents; Sulfonamides

2013
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy.
    Surgery today, 2013, Volume: 43, Issue:4

    Topics: Acute Lung Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Drug Administration Schedule; Drug Therapy, Combination; Esophageal Neoplasms; Esophagectomy; Female; Glycine; Humans; Intraoperative Care; Male; Methylprednisolone; Middle Aged; Postoperative Care; Postoperative Complications; Respiratory Distress Syndrome; Respiratory Function Tests; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome

2013
The use of neutrophil elastase inhibitor in the treatment of acute lung injury after pneumonectomy.
    Journal of cardiothoracic surgery, 2013, Apr-08, Volume: 8

    Topics: Acute Lung Injury; Adult; Aged; Combined Modality Therapy; Drug Administration Schedule; Glycine; Humans; Infusions, Intravenous; Male; Middle Aged; Pneumonectomy; Postoperative Complications; Proteinase Inhibitory Proteins, Secretory; Respiration, Artificial; Respiratory Distress Syndrome; Retrospective Studies; Sulfonamides; Treatment Outcome

2013
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis.
    Drug design, development and therapy, 2013, Volume: 7

    Topics: Acute Lung Injury; Aged; Calcitonin; Calcitonin Gene-Related Peptide; Female; Glycine; Humans; Male; Middle Aged; Oxygen; Protein Precursors; Proteinase Inhibitory Proteins, Secretory; Retrospective Studies; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Survival Rate

2013
Sivelestat attenuates myocardial reperfusion injury during brief low flow postischemic infusion.
    Oxidative medicine and cellular longevity, 2013, Volume: 2013

    Topics: Animals; Aorta; Cardiotonic Agents; Cattle; Coronary Circulation; Creatine Kinase; Electron Spin Resonance Spectroscopy; Endothelial Cells; Glycine; Heart Ventricles; In Vitro Techniques; Male; Models, Cardiovascular; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfonamides; Superoxides; Vasoconstriction; Ventricular Function, Left

2013
Protective effects of sivelestat in a caerulein-induced rat acute pancreatitis model.
    Inflammation, 2013, Volume: 36, Issue:6

    Topics: Amylases; Animals; Antioxidants; Ceruletide; Corticosterone; Disease Models, Animal; Glycine; Inflammation; Interleukin-1beta; Interleukin-4; Lipase; Male; Oxidative Stress; Pancreas; Pancreatitis, Acute Necrotizing; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors; Sulfonamides; Survival; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2013
[Neutrophil elastase inhibitor on proliferation and apoptosis of U937 cells].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2013, Volume: 34, Issue:6

    Topics: Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Glycine; Humans; Leukocyte Elastase; Piperidines; Proteinase Inhibitory Proteins, Secretory; Sulfonamides; U937 Cells

2013
The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.
    Anticancer research, 2013, Volume: 33, Issue:9

    Topics: Animals; Cecum; Cell Division; Cell Line; Gastrointestinal Neoplasms; Glycine; Leukocyte Elastase; Ligation; Mice; Mice, Inbred C57BL; Peritonitis; Serine Proteinase Inhibitors; Sulfonamides

2013
Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats.
    Drug and chemical toxicology, 2014, Volume: 37, Issue:1

    Topics: Acute Lung Injury; Animals; Glycine; Histological Techniques; Injections, Intraperitoneal; Interleukin-6; Lung; Male; Neutrophil Activation; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Sulfonamides; Tumor Necrosis Factor-alpha

2014
Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:4

    Topics: Animals; Cell Adhesion; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Immune System Diseases; Leukocyte Disorders; Liver Diseases; Male; Neutrophils; Rats; Rats, Wistar; Reperfusion Injury; Serine Proteinase Inhibitors; Sulfonamides; Systemic Inflammatory Response Syndrome

2014
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Glycine; Humans; Kinetics; Leukocyte Elastase; Mice, Inbred BALB C; Molecular Docking Simulation; Pentacyclic Triterpenes; Pneumonia; Proton Magnetic Resonance Spectroscopy; Saponins; Smoking; Sulfonamides; Triterpenes; Ursolic Acid

2013
Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers.
    Oncotarget, 2014, Jan-30, Volume: 5, Issue:2

    Topics: Amino Acid Sequence; Animals; Biomarkers, Tumor; Colorectal Neoplasms; Glycine; Humans; Leukocyte Elastase; Mice; Mice, Nude; Molecular Sequence Data; Molecular Targeted Therapy; Serine Proteinase Inhibitors; Sulfonamides; Xenograft Model Antitumor Assays

2014
Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2014, Volume: 122, Issue:9

    Topics: Acute Lung Injury; Animals; Endothelial Cells; Glycine; Intercellular Adhesion Molecule-1; Leukocyte Elastase; Lipopolysaccharides; Lung; Male; Neutrophil Infiltration; Peroxidase; Proteinase Inhibitory Proteins, Secretory; Pulmonary Edema; Rats; Rats, Wistar; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Transcription Factor RelA

2014
[Anesthetic management of posterior lumbar spinal fusion in a patient suspected of having acute exacerbation of chronic interstitial pneumonia].
    Masui. The Japanese journal of anesthesiology, 2014, Volume: 63, Issue:2

    Topics: Acute-Phase Reaction; Aged; Airway Management; Anesthesia; Chronic Disease; Disease Progression; Emergency Medical Services; Female; Glycine; Humans; Lumbar Vertebrae; Lung Diseases, Interstitial; Perioperative Care; Postoperative Complications; Respiration Disorders; Spinal Fusion; Spinal Stenosis; Sulfonamides

2014
Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis.
    Fukushima journal of medical science, 2014, Volume: 60, Issue:1

    Topics: Animals; Chemokines; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Glycine; Interleukin-17; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Peroxidase; Proteinase Inhibitory Proteins, Secretory; RNA, Messenger; Sulfonamides

2014
Effect of additional preoperative administration of the neutrophil elastase inhibitor sivelestat on perioperative inflammatory response after pediatric heart surgery with cardiopulmonary bypass.
    Artificial organs, 2014, Volume: 38, Issue:12

    Topics: C-Reactive Protein; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Glycine; Heart Septal Defects, Ventricular; Humans; Infant; Inflammation; Leukocyte Count; Male; Neutrophils; Pancreatic Elastase; Serine Proteinase Inhibitors; Sulfonamides; Treatment Outcome

2014
Combined effects of sivelestat and resveratrol on severe acute pancreatitis-associated lung injury in rats.
    Experimental lung research, 2014, Volume: 40, Issue:6

    Topics: Acute Disease; Amylases; Animals; Arterial Pressure; Bronchoalveolar Lavage Fluid; Glycine; Interleukin-6; Leukocyte Elastase; Lung; Lung Injury; Male; Oxygen; Pancreatitis; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Stilbenes; Sulfonamides

2014
[Effects of sivelestat on acute lung injury in dogs with severe burn-blast combined injury].
    Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2014, Volume: 30, Issue:2

    Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Capillary Permeability; Dogs; Extravascular Lung Water; Glycine; Infusions, Intravenous; Interleukin-8; Male; Pulmonary Edema; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha

2014
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Aged; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Glycine; Humans; Male; Middle Aged; Recombinant Proteins; Respiratory Distress Syndrome; Retrospective Studies; Solubility; Sulfonamides; Thrombomodulin

2014
Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.
    American journal of physiology. Lung cellular and molecular physiology, 2015, Jul-01, Volume: 309, Issue:1

    Topics: Animals; Animals, Newborn; Cell Movement; Elafin; Elastin; Female; Glycine; Leukocyte Elastase; Lung; Lung Injury; Macrophages; Maternal Exposure; Neutrophils; Oxygen; Peroxynitrous Acid; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-8B; Sulfonamides; Triazoles; Vascular Remodeling

2015
Elevation of pivaloylcarnitine by sivelestat sodium in two children.
    Molecular genetics and metabolism, 2015, Volume: 116, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Cardiomyopathies; Carnitine; Child, Preschool; Chromatography, Liquid; Female; Glycine; Humans; Hyperammonemia; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Muscular Diseases; Neonatal Screening; Serine Proteinase Inhibitors; Sulfonamides; Tandem Mass Spectrometry

2015
Post-fertilization effect of bilateral primary testicular damage induced by unilateral cryptorchidism in the rat model.
    Andrology, 2016, Volume: 4, Issue:2

    Topics: Animals; Animals, Newborn; Antioxidants; Cryptorchidism; Embryonic Development; Female; Fertility; Glycine; Male; Rats; Rats, Wistar; Sulfonamides; Taurine; Testis

2016
Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1.
    Journal of immunology (Baltimore, Md. : 1950), 2016, Feb-15, Volume: 196, Issue:4

    Topics: Animals; Annexin A1; Apoptosis; Blotting, Western; Flow Cytometry; Glycine; Humans; Inflammation; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neutrophils; Protease Inhibitors; Secretory Leukocyte Peptidase Inhibitor; Sulfonamides

2016
[Simultaneous determination of sivelestat and its metabolite XW-IMP-A in human plasma using HPLC-MS/MS].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:10

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Glycine; Humans; Inosine Monophosphate; Reproducibility of Results; Sulfonamides; Tandem Mass Spectrometry

2015
Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
    European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:3

    Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Burns; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-8; Leukocyte Elastase; Lung; Rats; Rats, Sprague-Dawley; Sulfonamides; Systemic Inflammatory Response Syndrome

2016
GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
    Neuroscience, 2016, 08-25, Volume: 330

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Disease Models, Animal; Drug Evaluation, Preclinical; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycine; Interleukin-1beta; Male; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Nuclear Proteins; Random Allocation; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Sulfonamides; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases

2016
Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice.
    Cell biochemistry and biophysics, 2015, Volume: 73, Issue:2

    Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apolipoproteins E; Chemokine CCL2; Diet, High-Fat; Disease Models, Animal; Glycine; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Kupffer Cells; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Non-alcoholic Fatty Liver Disease; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

2015
Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1.
    Acta cirurgica brasileira, 2016, Volume: 31, Issue:6

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glycine; Inflammation Mediators; Interleukin-6; Leukocyte Count; Leukocyte Elastase; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neutrophils; Sulfonamides; Survival Analysis; Tetracyclines; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factors

2016
The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.
    International journal of molecular medicine, 2016, Volume: 38, Issue:3

    Topics: Acute Kidney Injury; Animals; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Glomerular Filtration Rate; Glycine; HMGB1 Protein; Injections, Intraperitoneal; Interleukin-1beta; Kaplan-Meier Estimate; Kidney; Leukocyte Elastase; Lipocalin-2; Male; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Sepsis; Serine Proteinase Inhibitors; Sulfonamides; Tumor Necrosis Factor-alpha

2016
Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.
    American journal of respiratory cell and molecular biology, 2017, Volume: 56, Issue:2

    Topics: Animals; Cecum; Dexamethasone; Disease Models, Animal; Glycine; Ligation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred ICR; Multiple Organ Failure; Phosphatidylcholines; Punctures; Reactive Oxygen Species; Respiration, Artificial; Respiratory Distress Syndrome; Sulfonamides; Superoxide Dismutase

2017
Efficacy of early sivelestat administration on acute lung injury and acute respiratory distress syndrome.
    Respirology (Carlton, Vic.), 2017, Volume: 22, Issue:4

    Topics: Acute Lung Injury; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glycine; Humans; Male; Prognosis; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides; Time Factors; Treatment Outcome

2017
Inhibition of neutrophil elastase contributes to attenuation of lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice.
    Journal of anesthesia, 2017, Volume: 31, Issue:3

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Female; Glycine; Intercellular Adhesion Molecule-1; Interleukin-6; Leukocyte Elastase; Lipopolysaccharides; Lung; Mice; Mice, Inbred ICR; Neutropenia; Neutrophils; Pulmonary Edema; Sulfonamides; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2017
Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: propensity score analysis of a Japanese nationwide database.
    Journal of anesthesia, 2017, Volume: 31, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Databases, Factual; Female; Glycine; Humans; Japan; Male; Middle Aged; Pneumonia; Propensity Score; Respiration, Artificial; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides

2017
Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice.
    Biochemical and biophysical research communications, 2017, 04-22, Volume: 486, Issue:1

    Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Female; Gefitinib; Glycine; Humans; Kaplan-Meier Estimate; Leukocyte Count; Leukocyte Elastase; Lung; Mice, Inbred C57BL; Naphthalenes; Neutrophils; Pneumonia; Quinazolines; Serine Proteinase Inhibitors; Sulfonamides; Weight Loss

2017
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
    Journal of neuroinflammation, 2017, Aug-23, Volume: 14, Issue:1

    Topics: Animals; Chronic Pain; Glycine; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Osteoarthritis; Pre-Exposure Prophylaxis; Serine Proteinase Inhibitors; Sulfonamides

2017
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
    Pain, 2017, Volume: 158, Issue:11

    Topics: Analgesics; Animals; Cancer Pain; Chronic Pain; Cyclic S-Oxides; Disease Models, Animal; Female; Glycine; Hyperalgesia; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Pregabalin; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles

2017
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study.
    Early human development, 2017, Volume: 115

    Topics: Bronchopulmonary Dysplasia; Drug Administration Schedule; Female; Glycine; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Male; Serine Proteinase Inhibitors; Sulfonamides

2017
Prevention of Pulmonary Edema after Minimally Invasive Cardiac Surgery with Mini-Thoracotomy Using Neutrophil Elastase Inhibitor.
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2018, Feb-20, Volume: 24, Issue:1

    Topics: Adult; Aged; Cardiac Surgical Procedures; Female; Glycine; Humans; Infusions, Intravenous; Length of Stay; Leukocyte Elastase; Male; Middle Aged; One-Lung Ventilation; Pulmonary Edema; Retrospective Studies; Risk Factors; Serine Proteinase Inhibitors; Sulfonamides; Thoracotomy; Time Factors; Tomography, X-Ray Computed; Treatment Outcome

2018
Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.
    Biochemistry, 2018, 02-06, Volume: 57, Issue:5

    Topics: Animals; Cattle; Cysteine Proteases; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Glycine; HEK293 Cells; Humans; Leukocyte Elastase; Neutrophil Activation; Neutrophils; Serine Proteases; Sulfonamides; Swine

2018
Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG- and IgA-producing cells.
    European journal of immunology, 2018, Volume: 48, Issue:8

    Topics: Animals; B-Cell Activating Factor; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Glycine; Immunoglobulin A; Immunoglobulin G; Interleukin-10; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Neutrophils; Pancreatic Elastase; RNA, Messenger; Serine Proteinase Inhibitors; Spleen; Sulfonamides; Syndecan-1; Tumor Necrosis Factor Ligand Superfamily Member 13

2018
Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Glycine; Humans; Immunity, Innate; Leukocyte Elastase; Male; Mice, Inbred BALB C; NF-kappa B; Pneumonia, Pneumococcal; Serine Proteinase Inhibitors; Streptococcus pneumoniae; Sulfonamides; THP-1 Cells; Toll-Like Receptors

2018
Enhanced pause correlates with airway neutrophils and airway-epithelial injury in asthmatic mice treated with dexamethasone.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2019, Volume: 56, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Eosinophils; Female; Glycine; Inflammation; Lymphocytes; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyroglyphidae; Respiratory Mucosa; Respiratory System; Sulfonamides

2019
Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury.
    Acta neuropathologica communications, 2018, 08-07, Volume: 6, Issue:1

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Cicatrix; Cytokines; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Glycine; Humans; Laminin; Leukocyte Elastase; Nerve Tissue Proteins; Nociceptin; Occludin; Opioid Peptides; Rats; Rats, Sprague-Dawley; Recovery of Function; Serine Proteinase Inhibitors; Spinal Cord Injuries; Sulfonamides; Transforming Growth Factor beta1; Zonula Occludens-1 Protein

2018
ONO-5046 suppresses reactive oxidative species-associated formation of neutrophil extracellular traps.
    Life sciences, 2018, Oct-01, Volume: 210

    Topics: Adult; Cells, Cultured; Extracellular Traps; Glycine; Humans; Inflammation; Lipopolysaccharides; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Serine Proteinase Inhibitors; Sulfonamides

2018
Rolipram plus Sivelestat inhibits bone marrow-derived leukocytic lung recruitment after cardiopulmonary bypass in a primate model.
    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2019, Volume: 22, Issue:1

    Topics: Animals; Bone Marrow Cells; Cardiopulmonary Bypass; Chemotaxis, Leukocyte; Disease Models, Animal; Glycine; Lung; Macaca fascicularis; Male; Neutrophils; Phosphodiesterase 4 Inhibitors; Rolipram; Serine Proteinase Inhibitors; Sulfonamides

2019
Prophylactic sivelestat for esophagectomy and in-hospital mortality: a propensity score-matched analysis of claims database.
    Journal of anesthesia, 2019, Volume: 33, Issue:2

    Topics: Aged; Databases, Factual; Esophagectomy; Female; Glycine; Hospitals; Humans; Japan; Male; Middle Aged; Postoperative Complications; Propensity Score; Respiratory Distress Syndrome; Retrospective Studies; Serine Proteinase Inhibitors; Sulfonamides

2019
Neutrophil elastase inhibitor suppresses oxidative stress in obese asthmatic rats by activating Keap1/Nrf2 signaling pathway.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:1

    Topics: Animals; Antioxidants; Asthma; Disease Models, Animal; Glycine; Humans; Kelch-Like ECH-Associated Protein 1; Leukocyte Elastase; Male; NF-E2-Related Factor 2; Obesity; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serine Proteinase Inhibitors; Signal Transduction; Sulfonamides

2019
Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.
    Microbiology and immunology, 2019, Volume: 63, Issue:3-4

    Topics: Aggregatibacter actinomycetemcomitans; Cell Death; Cell Line; Epithelial Cells; Exotoxins; Fibroblasts; Gingiva; Glycine; Humans; Leukocyte Elastase; Neutrophils; Periodontitis; Sulfonamides; Virulence Factors

2019
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
    The American journal of pathology, 2019, Volume: 189, Issue:8

    Topics: Animals; Endothelium; Endotoxemia; Glycine; Glycocalyx; Leukocyte Elastase; Lipopolysaccharides; Lung; Mice; Mice, Knockout; Sulfonamides

2019
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
    International journal of molecular sciences, 2019, Oct-21, Volume: 20, Issue:20

    Topics: Animals; Brain Ischemia; Cells, Cultured; Cytokines; Disease Models, Animal; Glycine; Granulins; Leukocyte Elastase; Male; Microglia; Progranulins; Rats; Sulfonamides; Up-Regulation

2019
Neutrophil Elastase Inhibition Ameliorates Endotoxin-induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx.
    Shock (Augusta, Ga.), 2020, Volume: 54, Issue:3

    Topics: Animals; Endotoxemia; Endotoxins; Glycine; Glycocalyx; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-6; Leukocyte Elastase; Male; Mice; Mice, Knockout; Microscopy, Electron; Sulfonamides; Troponin I

2020
Neutrophil Elastase Inhibitor Sivelestat Attenuates Myocardial Injury after Cardioplegic Arrest in Rat Hearts.
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2020, Oct-21, Volume: 26, Issue:5

    Topics: Animals; Disease Models, Animal; Glycine; Heart Arrest, Induced; Isolated Heart Preparation; Leukocyte Elastase; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides; Troponin T; Ventricular Function, Left; Ventricular Pressure

2020
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
    Journal of leukocyte biology, 2020, Volume: 107, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Free Radical Scavengers; Glycine; Inflammation; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides

2020
Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis.
    International journal of molecular sciences, 2019, Dec-28, Volume: 21, Issue:1

    Topics: Actins; Animals; Bleomycin; Cells, Cultured; Chemokine CXCL1; Chemotaxis; Collagen; Glycine; Humans; Male; Mice; Mice, Inbred C57BL; Neutrophils; Particulate Matter; Pulmonary Fibrosis; Smad Proteins; Sulfonamides

2019
Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion.
    EBioMedicine, 2020, Volume: 53

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Coagulation; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Internal; Cell-Derived Microparticles; Extracellular Traps; Female; Fibrin; Glycine; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Neutrophils; Phosphatidylserines; Platelet Activation; Stroke; Sulfonamides; Thrombin

2020
Engineering synthetic breath biomarkers for respiratory disease.
    Nature nanotechnology, 2020, Volume: 15, Issue:9

    Topics: alpha 1-Antitrypsin Deficiency; Animals; Biomarkers; Breath Tests; Computer Simulation; Dose-Response Relationship, Drug; Drug Carriers; Female; Glycine; Humans; Leukocyte Elastase; Lung Diseases; Mass Spectrometry; Mice, Inbred Strains; Mice, Knockout; Nanostructures; Polyethylene Glycols; Pseudomonas Infections; Sulfonamides; Volatile Organic Compounds

2020
Tissue damage from neutrophil-induced oxidative stress in COVID-19.
    Nature reviews. Immunology, 2020, Volume: 20, Issue:9

    Topics: Acetylcysteine; Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokines; Drug Therapy, Combination; Extracellular Traps; Gene Expression Regulation; Glycine; Host-Pathogen Interactions; Humans; Immunity, Innate; Lung; Lymphocytes; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pandemics; Pneumonia, Viral; Proteinase Inhibitory Proteins, Secretory; Reactive Oxygen Species; SARS-CoV-2; Severity of Illness Index; Sulfonamides; Superoxide Dismutase

2020
Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
    Molecules (Basel, Switzerland), 2020, Oct-29, Volume: 25, Issue:21

    Topics: Antiviral Agents; Benzamidines; Betacoronavirus; Coronavirus Infections; COVID-19; Esters; Gabexate; Glycine; Guanidines; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Pandemics; Pneumonia, Viral; Protein Structure, Tertiary; SARS-CoV-2; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfonamides

2020
Sivelestat-loaded nanostructured lipid carriers modulate oxidative and inflammatory stress in human dental pulp and mesenchymal stem cells subjected to oxygen-glucose deprivation.
    Materials science & engineering. C, Materials for biological applications, 2021, Volume: 120

    Topics: Dental Pulp; Drug Carriers; Glucose; Glycine; Humans; Lipids; Mesenchymal Stem Cells; Nanostructures; Oxidative Stress; Oxygen; Sulfonamides

2021
Possible involvement of progranulin in the protective effect of elastase inhibitor on cerebral ischemic injuries of neuronal and glial cells.
    Molecular and cellular neurosciences, 2021, Volume: 113

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cytokines; Glycine; Male; Neuroglia; Neurons; Pancreatic Elastase; Progranulins; Rats; Rats, Wistar; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides

2021
Tissue neutrophil elastase contributes to extracorporeal shock wave lithotripsy-induced kidney damage and the neutrophil elastase inhibitor, sivelestat, attenuates kidney damage with gratifying immunohistopathological and biochemical findings: an experime
    Urolithiasis, 2022, Volume: 50, Issue:1

    Topics: Animals; Glycine; Kidney; Kidney Calculi; Leukocyte Elastase; Lithotripsy; Proteinase Inhibitory Proteins, Secretory; Rats; Sulfonamides

2022
Efficacy, safety, and pharmacoeconomics of sivelestat sodium in the treatment of septic acute respiratory distress syndrome: a retrospective cohort study.
    Annals of palliative medicine, 2021, Volume: 10, Issue:11

    Topics: Economics, Pharmaceutical; Glycine; Humans; Respiratory Distress Syndrome; Retrospective Studies; Sodium; Sulfonamides

2021
Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Animals; Gastrointestinal Microbiome; Glycine; Proteinase Inhibitory Proteins, Secretory; Rats; Rats, Sprague-Dawley; Sepsis; Sulfonamides

2022
Sivelestat's effect on Candida albicans water-soluble fraction-induced vasculitis.
    Pediatrics international : official journal of the Japan Pediatric Society, 2022, Volume: 64, Issue:1

    Topics: Animals; Candida albicans; Glycine; Humans; Intercellular Adhesion Molecule-1; Mice; Mucocutaneous Lymph Node Syndrome; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha; Vasculitis

2022
[Comparative study of the protective effect of Xuebijing injection and Sivelestat sodium on acute lung injury/acute respiratory distress syndrome rats].
    Zhonghua wei zhong bing ji jiu yi xue, 2022, Volume: 34, Issue:8

    Topics: Acute Lung Injury; Animals; Drugs, Chinese Herbal; Glycine; Interleukin-6; Lipopolysaccharides; Lung; Male; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sulfonamides

2022