sitagliptin-phosphate and minfiensine

Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.

Topics: Biological Products; Carbazoles; Catalysis; Diterpenes; Indans; Indole Alkaloids; Indolizines; Lactams; Pyrazines; Sitagliptin Phosphate; Spiro Compounds; Triazoles