sitagliptin and propionic-acid

sitagliptin has been researched along with propionic-acid* in 1 studies

Other Studies

1 other study(ies) available for sitagliptin and propionic-acid

Article	Year
Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists. Bioorganic & medicinal chemistry letters, 2014, Jul-01, Volume: 24, Issue:13 The G protein-coupled receptor 40 (GPR40) mediates enhancement of glucose-stimulated insulin secretion in pancreatic β cells. The GPR40 agonist has been attracting attention as a novel insulin secretagogue with glucose dependency for the treatment of type 2 diabetes. The optimization study of compound 1 led to a potent and bioavailable GPR40 agonist 24, which showed insulin secretion and glucose lowering effects in rat OGTT. Compound 24 is a potential lead compound for a novel insulin secretagogue with a low risk of hypoglycemia. Topics: Administration, Oral; Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Discovery; Glucose Tolerance Test; Humans; Molecular Structure; Propionates; Rats; Rats, Inbred F344; Rats, Zucker; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2014

Article

Year

Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.

Bioorganic & medicinal chemistry letters, 2014, Jul-01, Volume: 24, Issue:13

The G protein-coupled receptor 40 (GPR40) mediates enhancement of glucose-stimulated insulin secretion in pancreatic β cells. The GPR40 agonist has been attracting attention as a novel insulin secretagogue with glucose dependency for the treatment of type 2 diabetes. The optimization study of compound 1 led to a potent and bioavailable GPR40 agonist 24, which showed insulin secretion and glucose lowering effects in rat OGTT. Compound 24 is a potential lead compound for a novel insulin secretagogue with a low risk of hypoglycemia.

Topics: Administration, Oral; Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Discovery; Glucose Tolerance Test; Humans; Molecular Structure; Propionates; Rats; Rats, Inbred F344; Rats, Zucker; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2014