Page last updated: 2024-08-23

sisomicin and achn 490

sisomicin has been researched along with achn 490 in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	51 (65.38)	24.3611
2020's	27 (34.62)	2.80

Authors

Authors	Studies
Aggen, JB; Armstrong, ES; Diokno, R; Dozzo, P; Feeney, LA; Gliedt, MJ; Goldblum, AA; Gomez, M; Hildebrandt, DJ; Kubo, A; Linsell, MS; Lopez, S; Matias, RD; Miller, GH; Moser, HE; Wlasichuk, KB	1
Appelbaum, PC; Ednie, LM; Lin, G	1
Babu, E; Bäcker, M; Bratu, S; Kelly, P; Landman, D; Quale, J; Shah, N	2
Armstrong, ES; Miller, GH	1
Doumith, M; Livermore, DM; Maharjan, S; Mushtaq, S; Warner, M; Woodford, N; Zhang, JC	1
Armstrong, ES; Kubo, A; Lopez, S; Miller, GH; Persing, DH; Tenover, FC; Tickler, I	1
Borin, MT; Brooks, CD; Bruss, JB; Cass, RT; Havrilla, NA; Tack, KJ; Young, D	1
Campbell, RL; Cheng, L; Hirtzer, P; Karr, DE; Schmidt, DE; Tan, L; Wlasichuk, KB	1
Adam, H; Findlay, B; Gin, AS; Hoban, DJ; Karlowsky, JA; Lawson, CD; Lynch, JP; Rubinstein, E; Schweizer, F; Walkty, A; Zelenitsky, S; Zhanel, GG	1
Argyropoulou, A; Chrysouli, Z; Daikos, GL; Galani, I; Giamarellou, H; Panagea, T; Petrikkos, G; Plakias, G; Poulakou, G; Psichogiou, M; Souli, M; Stefanou, I	1
Adam, H; Baxter, M; Denisuik, A; Hoban, DJ; Karlowsky, JA; Lagacé-Wiens, P; Walkty, A; Zhanel, GG	1
Baluya, D; Brown, D; Cirz, R; Drusano, GL; Fikes, S; Kurhanewicz, S; Liu, W; Louie, A; Robbins, N; Rodriquez, J	1
Almaghrabi, R; Chen, L; Clancy, CJ; Doi, Y; Hao, B; Iovine, NM; Kreiswirth, B; Nguyen, MH; Press, EG; Shields, RK; Townsend, BM; Wagener, MM	1
Carlson, SA; Olsen, SC	1
Culebras, E; García-Salguero, C; Picazo, JJ; Rodríguez-Avial, I	1
Culebras, E; Pena, I; Picazo, JJ; Rodríguez-Avial, C; Rodríguez-Avial, I	1
Giamarellou, H; Karaiskos, I; Souli, M	1
Amin, AN; Cerceo, E; Deitelzweig, SB; Sherman, BM	1
Alkroud, A; Cheng, S; Churilla, BM; Churilla, TM; Clancy, CJ; Doi, Y; Haidar, G; Nguyen, MH; Shields, RK	1
Cass, RT; Cirz, RT; Doyle-Eisele, M; Kostrub, CF; Mega, WM; Metz, MA; Sherwood, RL	1
Culebras, E; López-Diaz, MD; Picazo, JJ; Rios, E; Rodríguez-Avial, C; Rodríguez-Avial, I; Viñuela-Prieto, JM	1
Culebras, E; López Díaz, MC; Picazo, JJ; Ríos, E; Rodríguez-Avial, I; Simaluiza, RJ	1
Bush, K; Kashikar, A; Zhang, Y	1
Connolly, LE; Denervaud-Tendon, V; Krause, KM; Nordmann, P; Poirel, L	1
Bail, L; da Silva Nogueira, K; Dalmolin, TV; Ito, CAS; Martins, AF; Martins, AS; Rocha, JLL; Serio, AW; Tuon, FF	1
Armstrong, ES; Cebrik, D; Connolly, LE; Miller, LG; Riddle, V	1
Kidd, JM; Kuti, JL; Nicolau, DP	1
Bordeleau, E; Cox, G; Ejim, L; Evdokimova, E; Koteva, K; Krause, KM; Savchenko, A; Serio, AW; Sieron, AO; Stogios, PJ; Wright, GD	1
Asempa, TE; Avery, LM; Kidd, JM; Kuti, JL; Nicolau, DP	1
Paul, M; Theuretzbacher, U	1
Hall, D; Krause, KM; Marra, A; Pillar, C; Serio, AW; Shinabarger, D; Stoneburner, A; Thwaites, M	1
Castanheira, M; Deshpande, LM; Flamm, RK; Krause, KM; Serio, AW; Woosley, LN	1
Gibbons, JA; Komirenko, AS; Riddle, V; Seroogy, JD; Van Wart, S	1
McCarthy, MW	1
Andrews, L; Keepers, T; Krause, KM; Serio, AW	1
Chahine, EB; Cho, JC; Piccicacco, N; Shaeer, KM; Zmarlicka, MT	1
Choi, T; Dhuria, SV; Kim, A; Komirenko, AS; Riddle, V	1
Choi, T; Gall, J; Gibbons, JA; Riddle, V; Seroogy, J; Van Wart, S	1
Castanheira, M; Davis, AP; Krause, KM; Mendes, RE; Serio, AW	1
Alharbi, A; Alshehri, S; Eljaaly, K; Ortwine, JK; Pogue, JM	1
Cebrik, DS; Cloutier, DJ; Connolly, LE; Dwyer, JP; Friedland, I; Keepers, TR; Komirenko, AS; Krause, KM; Miller, LG; Wagenlehner, FME	1
Baden, L; Cox, E; Nambiar, S	1
Connolly, LE; Daikos, GL; Dwyer, JP; Friedland, I; Jubb, AM; Krause, KM; McKinnell, JA; Serio, AW; Smith, A; Talbot, GH	1
Fenner, A	1
Schaeffer, EM	1
Attwood, M; Bowker, KE; Kim, A; Krause, KM; MacGowan, AP; Noel, AR	1
Saravolatz, LD; Stein, GE	1
Culebras, E; Emiliov, T; López-Diaz, MDC; Rodríguez-Avial, I	1
Hussar, DA	1
Roschkow, M	1
Lai, CC; Tang, HJ	1
Lin, WT; Wang, JH	1
Chiotos, K; Gerber, JS; Hayes, M; Tamma, PD	1
Castanheira, M; Jones, RN; Mendes, RE; Sader, HS	1
Bilinskaya, A; Kuti, JL; Linder, KE	1
Aksu, B; Çakar, A; Çavuşoğlu, İ; Çelik, T; Gür, D; Hasdemir, U	1
Burgess, DS; Clark, JA; Kulengowski, B	1
Bassetti, M; Battaglini, D; Giacobbe, DR; Pelosi, P; Vena, A	1
Arend, LNVS; Bail, L; Ito, CAS; Nogueira, KDS; Pilonetto, M; Tuon, FF	1
Andrey, DO; Gales, AC; Martins, WMBS; Roch, M; Sands, K; Schrenzel, J; Sierra, R; Walsh, TR	1
Nambiar, S; Schumann, K; Walinsky, S	1
Clabots, C; Johnson, JR; Johnston, BD; Porter, SB; Thuras, P	1
Garcia, JA; Liang, SY; Long, B; Matlock, A; Moussavi, K	1
Pregnolato, M; Taccani, M; Terreni, M	1
Arya, DP; Bassenden, AV; Berghuis, AM; Blanchet, J; Dumalo, L; Maiti, K; Park, J	1
Anacker, M; Castanheira, M; Johnson, JR; Johnston, BD; Porter, SB; Snippes Vagnone, P; Thuras, P; VonBank, B; Witwer, M	1
Arya, DP; Bassenden, AV; Berghuis, AM; Golkar, T; Maiti, K; Schmeing, TM	1
Bianco, G; Boattini, M; Cavallo, R; Costa, C; Iannaccone, M	1
Bonegio, RGB; Branch-Elliman, W; Earle, W; Smith, DB	1
Başustaoğlu, A; Erol, Ç; Gümüş, H; İnce, G; Mirza, HC; Üsküdar Güçlü, A	1
Armstrong, TP; Blanchard, LS; Dechaume, D; Emery, CL; Halimi, D; Kresken, M; Pompilio, M; Van Belkum, A; Ying, YX; Zambardi, G	1
Kasimati, A; Magkafouraki, E; Maraki, S; Mavromanolaki, VE; Moraitis, P; Scoulica, E; Stafylaki, D	1
Abdel-Razek, AS; Abdelaziz, G; El-Kawy, OA	1
Iarikov, D; Jang, SH; Mishra, S; Reynolds, KS; Wu, K; Zhuang, L	1
Bakkaloglu, Z; Demirbas, Z; Dizbay, M; Ozger, HS; Suzuk-Yildiz, S	1
Luterbach, CL; Rao, GG	1

Reviews

16 review(s) available for sisomicin and achn 490

Article	Year
Combating evolution with intelligent design: the neoglycoside ACHN-490. Current opinion in microbiology, 2010, Volume: 13, Issue:5 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Microbial Sensitivity Tests; Molecular Structure; Sisomicin	2010
Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin. Expert review of anti-infective therapy, 2012, Volume: 10, Issue:4 Topics: Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gentamicins; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Sisomicin; Tobramycin	2012
Plazomicin: an investigational therapy for the treatment of urinary tract infections. Expert opinion on investigational drugs, 2015, Volume: 24, Issue:11 Topics: Acute Disease; Animals; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Humans; Pyelonephritis; Sisomicin; Urinary Tract Infections	2015
Multidrug-Resistant Gram-Negative Bacterial Infections in the Hospital Setting: Overview, Implications for Clinical Practice, and Emerging Treatment Options. Microbial drug resistance (Larchmont, N.Y.), 2016, Volume: 22, Issue:5 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Boronic Acids; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Enterobacteriaceae Infections; Escherichia coli; Heterocyclic Compounds, 1-Ring; Hospitals; Humans; Klebsiella pneumoniae; Meropenem; Pseudomonas aeruginosa; Sisomicin; Tetracyclines; Thienamycins	2016
Novel pharmacotherapy for the treatment of hospital-acquired and ventilator-associated pneumonia caused by resistant gram-negative bacteria. Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:4 Topics: Administration, Inhalation; Amikacin; Anti-Bacterial Agents; Ceftazidime; Cephalosporins; Clinical Trials as Topic; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Humans; Pneumonia, Ventilator-Associated; Sisomicin	2018
Plazomicin for the treatment of patients with complicated urinary tract infection. Drugs of today (Barcelona, Spain : 1998), 2018, Volume: 54, Issue:9 Topics: Anti-Bacterial Agents; Humans; Sisomicin; Urinary Tract Infections	2018
Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus, 2018, Volume: 8, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Humans; Microbial Sensitivity Tests; Protein Synthesis Inhibitors; Sisomicin	2018
Plazomicin: A Next-Generation Aminoglycoside. Pharmacotherapy, 2019, Volume: 39, Issue:1 Topics: Adult; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Sisomicin; Urinary Tract Infections	2019
Plazomicin: A Novel Aminoglycoside for the Treatment of Resistant Gram-Negative Bacterial Infections. Drugs, 2019, Volume: 79, Issue:3 Topics: Animals; Anti-Bacterial Agents; Carbapenems; Clinical Trials as Topic; Colistin; Dose-Response Relationship, Drug; Drug Approval; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Meropenem; Randomized Controlled Trials as Topic; Sisomicin; United States; United States Food and Drug Administration; Urinary Tract Infections	2019
Plazomicin: A New Aminoglycoside. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 02-03, Volume: 70, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Humans; Sisomicin	2020
Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children. Journal of the Pediatric Infectious Diseases Society, 2020, Feb-28, Volume: 9, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Child; Drug Therapy, Combination; Enterobacteriaceae Infections; Humans; Polymyxins; Sisomicin; Tetracyclines; Tigecycline	2020
Plazomicin: an intravenous aminoglycoside antibacterial for the treatment of complicated urinary tract infections. Expert review of anti-infective therapy, 2020, Volume: 18, Issue:8 Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Sisomicin; Urinary Tract Infections	2020
The role of new antimicrobials for Gram-negative infections in daily clinical practice. Current opinion in infectious diseases, 2020, Volume: 33, Issue:6 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Azabicyclo Compounds; beta-Lactams; Carbapenems; Cefiderocol; Ceftazidime; Cephalosporins; Drug Combinations; Drug Resistance, Bacterial; Gram-Negative Bacterial Infections; Humans; Imipenem; Microbial Sensitivity Tests; Polymyxins; Sisomicin; Tazobactam; Tetracyclines	2020
Advances in novel antibiotics to treat multidrug-resistant gram-negative bacterial infections. Internal and emergency medicine, 2021, Volume: 16, Issue:8 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Boronic Acids; Cefiderocol; Ceftazidime; Cephalosporins; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Design; Drug Resistance, Multiple; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Heterocyclic Compounds, 1-Ring; Humans; Meropenem; Sisomicin; Tazobactam; Tetracyclines	2021
New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives. Molecules (Basel, Switzerland), 2021, May-02, Volume: 26, Issue:9 Topics: Animals; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Boronic Acids; Cefiderocol; Cephalosporins; Chemistry, Pharmaceutical; Clostridioides difficile; Clostridium Infections; Drug Design; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Gonorrhea; Humans; Meropenem; Neisseria gonorrhoeae; Nitroimidazoles; Sisomicin; Tetracyclines	2021
Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin. Current opinion in microbiology, 2022, Volume: 70 Topics: Adult; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Humans; Sisomicin	2022

Trials

7 trial(s) available for sisomicin and achn 490

Article	Year
Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:12 Topics: Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Half-Life; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Sisomicin; Treatment Outcome; Young Adult	2011
A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:4 Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Levofloxacin; Male; Middle Aged; Pyelonephritis; Sisomicin; Urinary Tract Infections; Young Adult	2018
A Phase 1 Study To Assess the Pharmacokinetics of Intravenous Plazomicin in Adult Subjects with Varying Degrees of Renal Function. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:12 Topics: Aged; Anti-Bacterial Agents; Area Under Curve; Drug Administration Schedule; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Infusions, Intravenous; Kidney; Kidney Function Tests; Male; Middle Aged; Renal Insufficiency; Severity of Illness Index; Sisomicin; Urinary Tract Infections	2018
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects. Clinical pharmacology in drug development, 2019, Volume: 8, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Adult; Area Under Curve; Cross-Over Studies; Drug Interactions; Female; Gene Expression Regulation; Healthy Volunteers; HEK293 Cells; Humans; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Sisomicin; Young Adult	2019
A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics. Clinical pharmacology in drug development, 2019, Volume: 8, Issue:8 Topics: Adult; Anti-Bacterial Agents; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Sisomicin	2019
Once-Daily Plazomicin for Complicated Urinary Tract Infections. The New England journal of medicine, 2019, 02-21, Volume: 380, Issue:8 Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Patient Acuity; Sisomicin; Urinary Tract Infections	2019
Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae. The New England journal of medicine, 2019, 02-21, Volume: 380, Issue:8 Topics: Anti-Bacterial Agents; Bacteremia; Carbapenem-Resistant Enterobacteriaceae; Colistin; Creatinine; Drug Resistance, Bacterial; Enterobacteriaceae Infections; Healthcare-Associated Pneumonia; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Sample Size; Sisomicin	2019

Other Studies

55 other study(ies) available for sisomicin and achn 490

Article	Year
Synthesis and spectrum of the neoglycoside ACHN-490. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Enterobacteriaceae; Microbial Sensitivity Tests; Molecular Structure; Proteus mirabilis; Pseudomonas aeruginosa; Sisomicin	2010
Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5 Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Daptomycin; Drug Resistance, Bacterial; Drug Synergism; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxazolidinones; Sisomicin; Time Factors	2010
Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City. The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; DNA, Bacterial; Escherichia coli; Escherichia coli Infections; Hospitals; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Sequence Data; New York City; Polymerase Chain Reaction; Sequence Analysis, DNA; Sisomicin; tRNA Methyltransferases	2010
Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Microbial Sensitivity Tests; Polymerase Chain Reaction; Sequence Analysis, DNA; Sisomicin; tRNA Methyltransferases	2011
Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City. The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:2 Topics: Acinetobacter baumannii; Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; New York City; Pseudomonas aeruginosa; Sisomicin	2011
Activity of ACHN-490 against meticillin-resistant Staphylococcus aureus (MRSA) isolates from patients in US hospitals. International journal of antimicrobial agents, 2011, Volume: 38, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Blood; Drug Resistance, Bacterial; Hospitals; Humans; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Nose; Sisomicin; Staphylococcal Infections; Tobramycin; United States	2011
A high pH based reversed-phase high performance liquid chromatographic method for the analysis of aminoglycoside plazomicin and its impurities. Journal of pharmaceutical and biomedical analysis, 2012, Volume: 66 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug Contamination; Hydrogen-Ion Concentration; Limit of Detection; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Sisomicin	2012
Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece. Journal of chemotherapy (Florence, Italy), 2012, Volume: 24, Issue:4 Topics: Amikacin; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterobacter; Enterobacteriaceae Infections; Escherichia coli; Escherichia coli Infections; Gentamicins; Greece; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin; Tertiary Care Centers; Tobramycin	2012
In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in canadian hospitals as part of the CANWARD study, 2011-2012. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:5 Topics: Anti-Bacterial Agents; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Sisomicin; Staphylococcus aureus	2014
Interaction of drug- and granulocyte-mediated killing of Pseudomonas aeruginosa in a murine pneumonia model. The Journal of infectious diseases, 2014, Oct-15, Volume: 210, Issue:8 Topics: Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Female; Granulocytes; Mice; Microbial Sensitivity Tests; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Sisomicin	2014
Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Drug Combinations; Drug Resistance, Multiple, Bacterial; Enzyme Assays; Gene Expression; Gentamicins; Isoenzymes; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin	2014
In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp. International journal of antimicrobial agents, 2015, Volume: 45, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Brucella abortus; Brucella melitensis; Brucella suis; Brucellosis; Humans; Microbial Sensitivity Tests; Microbial Viability; Sisomicin	2015
Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii? Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10 Topics: Acinetobacter baumannii; Acinetobacter Infections; Amikacin; Anti-Bacterial Agents; beta-Lactam Resistance; Cross Infection; Drug Synergism; Drug Therapy, Combination; Humans; Imipenem; Meropenem; Microbial Sensitivity Tests; Sisomicin; Thienamycins	2015
In vitro activity of the next-generation aminoglycoside plazomicin alone and in combination with colistin, meropenem, fosfomycin or tigecycline against carbapenemase-producing Enterobacteriaceae strains. International journal of antimicrobial agents, 2015, Volume: 46, Issue:6 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Colistin; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Enterobacter; Enterobacteriaceae Infections; Fosfomycin; Humans; Klebsiella oxytoca; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Minocycline; Serratia marcescens; Sisomicin; Thienamycins; Tigecycline	2015
Association between the Presence of Aminoglycoside-Modifying Enzymes and In Vitro Activity of Gentamicin, Tobramycin, Amikacin, and Plazomicin against Klebsiella pneumoniae Carbapenemase- and Extended-Spectrum-β-Lactamase-Producing Enterobacter Species. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:9 Topics: Amikacin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Biotransformation; Drug Resistance, Multiple, Bacterial; Enterobacter; Escherichia coli; Gene Expression; Gentamicins; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin; Tobramycin	2016
Plazomicin is effective in a non-human primate pneumonic plague model. Bioorganic & medicinal chemistry, 2016, 12-15, Volume: 24, Issue:24 Topics: Animals; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Molecular Conformation; Plague; Sisomicin	2016
Plazomicin Activity against 346 Extended-Spectrum-β-Lactamase/AmpC-Producing Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactamases; Escherichia coli; Microbial Sensitivity Tests; Sisomicin; Urinary Tract	2017
In-vitro activity of several antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA) isolates expressing aminoglycoside-modifying enzymes: potency of plazomicin alone and in combination with other agents. International journal of antimicrobial agents, 2017, Volume: 50, Issue:2 Topics: Aminoglycosides; Anti-Infective Agents; Drug Synergism; Humans; Inactivation, Metabolic; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Sisomicin	2017
In vitro activity of plazomicin against β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE). The Journal of antimicrobial chemotherapy, 2017, 10-01, Volume: 72, Issue:10 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Enterobacteriaceae Infections; Humans; Imipenem; Indiana; Klebsiella pneumoniae; Methyltransferases; Microbial Sensitivity Tests; Sisomicin	2017
Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates. The Journal of antimicrobial chemotherapy, 2017, 10-01, Volume: 72, Issue:10 Topics: Africa; Anti-Bacterial Agents; Bacterial Proteins; Colistin; Colombia; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli; Escherichia coli Proteins; Europe; Humans; Klebsiella oxytoca; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin	2017
Antimicrobial activity of plazomicin against Enterobacteriaceae-producing carbapenemases from 50 Brazilian medical centers. Diagnostic microbiology and infectious disease, 2018, Volume: 90, Issue:3 Topics: Amikacin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Brazil; Carbapenem-Resistant Enterobacteriaceae; Colistin; Drug Resistance, Multiple, Bacterial; Gentamicins; Hospitals; Humans; Meropenem; Microbial Sensitivity Tests; Sisomicin; Thienamycins	2018
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS infectious diseases, 2018, 06-08, Volume: 4, Issue:6 Topics: Acetyltransferases; Aminoglycosides; Anti-Bacterial Agents; Escherichia coli; Humans; Mass Spectrometry; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Molecular Structure; Sisomicin; Structure-Activity Relationship	2018
Physical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2018, Jul-15, Volume: 75, Issue:14 Topics: Anti-Bacterial Agents; Drug Compounding; Drug Incompatibility; Glucose; Humans; Infusions, Intravenous; Nephelometry and Turbidimetry; Sisomicin; Sodium Chloride	2018
Developing a new antibiotic for extensively drug-resistant pathogens: the case of plazomicin. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2018, Volume: 24, Issue:12 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Randomized Controlled Trials as Topic; Sisomicin	2018
Activity of plazomicin in combination with other antibiotics against multidrug-resistant Enterobacteriaceae. Diagnostic microbiology and infectious disease, 2018, Volume: 92, Issue:4 Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Microbial Sensitivity Tests; Microbial Viability; Sisomicin; Time Factors	2018
Activity of plazomicin compared with other aminoglycosides against isolates from European and adjacent countries, including Enterobacteriaceae molecularly characterized for aminoglycoside-modifying enzymes and other resistance mechanisms. The Journal of antimicrobial chemotherapy, 2018, 12-01, Volume: 73, Issue:12 Topics: Aminoglycosides; Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Epidemiological Monitoring; Europe; Humans; Microbial Sensitivity Tests; RNA, Ribosomal, 16S; Sisomicin	2018
In vitro activity of Plazomicin against Enterobacteriaceae isolates carrying genes encoding aminoglycoside-modifying enzymes most common in US Census divisions. Diagnostic microbiology and infectious disease, 2019, Volume: 94, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Enzymes; Hospitals; Microbial Sensitivity Tests; Sisomicin; United States	2019
Plazomicin (Zemdri) - a new aminoglycoside antibiotic. The Medical letter on drugs and therapeutics, 2018, Nov-05, Volume: 60, Issue:1559 Topics: Administration, Intravenous; Anti-Bacterial Agents; Drug Costs; Humans; Sisomicin; Treatment Outcome; Urinary Tract Infections	2018
Needed: Antimicrobial Development. The New England journal of medicine, 2019, 02-21, Volume: 380, Issue:8 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Humans; Sisomicin; Urinary Tract Infections	2019
Plazomicin once daily effective for complicated UTI. Nature reviews. Urology, 2019, Volume: 16, Issue:5 Topics: Humans; Sisomicin; Urinary Tract Infections	2019
Re: Once-Daily Plazomicin for Complicated Urinary Tract Infections. The Journal of urology, 2019, Volume: 202, Issue:4 Topics: Humans; Sisomicin; Urinary Tract Infections	2019
Pharmacodynamics of plazomicin and a comparator aminoglycoside, amikacin, studied in an in vitro pharmacokinetic model of infection. International journal of antimicrobial agents, 2019, Volume: 54, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Bacterial Load; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin	2019
Comparative evaluation of plazomicin MICs obtained using agar dilution versus broth microdilution methods and impact of inoculum size against ESBL-producing Escherichia coli, carbapenemase-producing Klebsiella pneumoniae and methicillin-resistant Staphylo Diagnostic microbiology and infectious disease, 2019, Volume: 95, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Load; Bacterial Proteins; beta-Lactamases; Drug Resistance, Bacterial; Escherichia coli; Humans; Klebsiella pneumoniae; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Sisomicin	2019
New Drugs 2019, part 4. Nursing, 2019, Volume: 49, Issue:11 Topics: Aminopyridines; Cinnamates; Drug Approval; Factor Xa; Humans; Macrolides; Morpholines; Oligonucleotides; Oxazines; Pyridines; Pyrimidines; Recombinant Proteins; RNA, Small Interfering; Sisomicin; Tetracyclines; Thiazoles; Thiophenes; United States; United States Food and Drug Administration	2019
[Plazomicin-a new antibiotic for complicated urinary tract infections]. Der Urologe. Ausg. A, 2019, Volume: 58, Issue:11 Topics: Anti-Bacterial Agents; Humans; Sisomicin; Treatment Outcome; Urinary Tract Infections	2019
Plazomicin-associated Nephrotoxicity. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 08-14, Volume: 71, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Humans; Sisomicin	2020
Plazomicin for treating complicated urinary tract infection. The Journal of infection, 2020, Volume: 80, Issue:2 Topics: Colistin; Humans; Pseudomonas aeruginosa; Sisomicin; Urinary Tract Infections	2020
Activity of Plazomicin Tested against Antimicrobial agents and chemotherapy, 2020, 04-21, Volume: 64, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Hospitals; Humans; Microbial Sensitivity Tests; RNA, Ribosomal, 16S; Sisomicin; United States	2020
Comparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferases. Diagnostic microbiology and infectious disease, 2020, Volume: 97, Issue:4 Topics: Acetyltransferases; Aminoglycosides; Bacterial Proteins; beta-Lactamases; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Methyltransferases; Microbial Sensitivity Tests; Prevalence; RNA, Ribosomal, 16S; Sisomicin; Turkey	2020
In vitro activity of plazomicin compared to other clinically relevant aminoglycosides in carbapenem-resistant Enterobacteriaceae. Diagnostic microbiology and infectious disease, 2020, Volume: 98, Issue:2 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Drug Resistance, Multiple, Bacterial; Gentamicins; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin; Tobramycin	2020
Distribution of genes encoding 16S rRNA methyltransferase in plazomicin-nonsusceptible carbapenemase-producing Enterobacterales in Brazil. Diagnostic microbiology and infectious disease, 2021, Volume: 99, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Brazil; Carbapenem-Resistant Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Methyltransferases; Microbial Sensitivity Tests; Sisomicin	2021
Vertical and horizontal dissemination of an IncC plasmid harbouring rmtB 16S rRNA methylase gene, conferring resistance to plazomicin, among invasive ST258 and ST16 KPC-producing Klebsiella pneumoniae. Journal of global antimicrobial resistance, 2021, Volume: 24 Topics: Bacterial Proteins; beta-Lactamases; Brazil; Humans; Interleukins; Klebsiella pneumoniae; Methyltransferases; Microbial Sensitivity Tests; Plasmids; RNA, Ribosomal, 16S; Sisomicin	2021
FDA's Limited Population Pathway for Antibacterial and Antifungal Drugs. Clinical pharmacology and therapeutics, 2021, Volume: 109, Issue:4 Topics: Administration, Inhalation; Amikacin; Anti-Bacterial Agents; Antifungal Agents; Cross Infection; Drug Approval; Drug Resistance, Microbial; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Humans; Liposomes; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Nitroimidazoles; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Sisomicin; United States; United States Food and Drug Administration	2021
Comparative activity of plazomicin against extended-spectrum cephalosporin-resistant Escherichia coli clinical isolates (2012-2017) in relation to phylogenetic background, sequence type 131 subclones, bla European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021, Volume: 40, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamases; Cephalosporins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Female; Genotype; Humans; Imipenem; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Phylogeny; Sisomicin; Young Adult	2021
Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes. Scientific reports, 2021, 06-02, Volume: 11, Issue:1 Topics: Acetyltransferases; Amikacin; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Drug Resistance, Bacterial; Escherichia coli; Gene Expression; Genetic Vectors; Humans; Kinetics; Models, Molecular; Netilmicin; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Providencia; Recombinant Proteins; Sisomicin; Substrate Specificity; Tobramycin	2021
Activity of plazomicin against carbapenem-intermediate or -resistant Escherichia coli isolates from the United States and international sites in relation to clonal background, resistance genes, co-resistance, and region. The Journal of antimicrobial chemotherapy, 2021, 07-15, Volume: 76, Issue:8 Topics: Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Drug Resistance, Multiple, Bacterial; Escherichia coli; Humans; Microbial Sensitivity Tests; Phylogeny; Sisomicin; United States	2021
Structural basis for plazomicin antibiotic action and resistance. Communications biology, 2021, 06-11, Volume: 4, Issue:1 Topics: Anti-Bacterial Agents; Binding Sites; Crystallography, X-Ray; Drug Resistance, Bacterial; Methylation; Providencia; Ribosomes; RNA, Ribosomal, 16S; RNA, Transfer; Sisomicin; Structure-Activity Relationship	2021
Evaluation of synergistic activity of plazomicin-based combinations against KPC-producing Journal of chemotherapy (Florence, Italy), 2022, Volume: 34, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamases; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Genes, Bacterial; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin	2022
Plazomicin for the treatment of multidrug-resistant BMJ case reports, 2021, Aug-19, Volume: 14, Issue:8 Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Multiple, Bacterial; Humans; Klebsiella; Male; Renal Insufficiency, Chronic; Renal Replacement Therapy; Sisomicin	2021
Comparison of in vitro activities of plazomicin and other aminoglycosides against clinical isolates of Klebsiella pneumoniae and Escherichia coli. The Journal of antimicrobial chemotherapy, 2021, 11-12, Volume: 76, Issue:12 Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactamases; Escherichia coli; Klebsiella pneumoniae; Microbial Sensitivity Tests; Sisomicin	2021
Multicenter Clinical Evaluation of ETEST Plazomicin (PLZ) for Susceptibility Testing of Enterobacterales. Journal of clinical microbiology, 2022, 01-19, Volume: 60, Issue:1 Topics: Anti-Bacterial Agents; Disk Diffusion Antimicrobial Tests; Enterobacteriaceae; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Sisomicin	2022
Epidemiology and in vitro activity of ceftazidime-avibactam, meropenem-vaborbactam, imipenem-relebactam, eravacycline, plazomicin, and comparators against Greek carbapenemase-producing Klebsiella pneumoniae isolates. Infection, 2022, Volume: 50, Issue:2 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; beta-Lactamases; Boronic Acids; Ceftazidime; Drug Combinations; Humans; Imipenem; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Multilocus Sequence Typing; Sisomicin; Tetracyclines	2022
Radiolabeling, characterization, and preclinical evaluation of plazomicin: A potential tracer for bacterial infection. Chemical biology & drug design, 2022, Volume: 99, Issue:5 Topics: Anti-Bacterial Agents; Bacterial Infections; Humans; Radiopharmaceuticals; Sisomicin; Technetium; Tissue Distribution	2022
Application of Population Pharmacokinetic Modeling, Exposure-Response Analysis, and Classification and Regression Tree Analysis to Support Dosage Regimen and Therapeutic Drug Monitoring of Plazomicin in Complicated Urinary Tract Infection Patients with Re Antimicrobial agents and chemotherapy, 2022, 04-19, Volume: 66, Issue:4 Topics: Adult; Anti-Bacterial Agents; Drug Monitoring; Female; Humans; Male; Renal Insufficiency; Sisomicin; Urinary Tract Infections	2022
In Vitro Activity of Plazomicin Against Carbapenem Resistant Klebsiella pneumoniae Strains. Clinical laboratory, 2022, Jun-01, Volume: 68, Issue:6 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Carbapenem-Resistant Enterobacteriaceae; Gentamicins; Humans; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Sisomicin; Tobramycin	2022