sirolimus and saracatinib

sirolimus has been researched along with saracatinib* in 1 studies

Reviews

1 review(s) available for sirolimus and saracatinib

ArticleYear
Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.
    Psychopharmacology, 2018, Volume: 235, Issue:6

    In recent years, research has identified the molecular and neural substrates underlying the transition of moderate "social" consumption of alcohol to the characteristic alcohol use disorder (AUD) phenotypes including excessive and compulsive alcohol use which we define in the review as the GO signaling pathways. In addition, growing evidence points to the existence of molecular mechanisms that keep alcohol consumption in check and that confer resilience for the development of AUD which we define herein as the STOP signaling pathways. In this review, we focus on examples of the GO and the STOP intracellular signaling pathways and discuss our current knowledge of how manipulations of these pathways may be used for the treatment of AUD.

    Topics: Alcohol Drinking; Alcoholism; Animals; Benzodioxoles; Brain-Derived Neurotrophic Factor; Drug Delivery Systems; Ethanol; Humans; Intracellular Fluid; Quinazolines; Signal Transduction; Sirolimus; Treatment Outcome

2018