sirolimus and homoserine-lactone

N-(3-oxododecanoyl) homoserine lactone (3oc) is a Pseudomonas aeruginosa secreted quorum-sensing signal molecule playing a crucial role in regulating quorum-sensing (QS) dependent biofilm formation and secretion of virulence factors. In addition to regulating quorum sensing, 3oc also plays an immunomodulatory role in the host by triggering regulated cell death in immune cells. The molecular mechanisms of 3oc in modulating macrophage pathologies are still unclear. In this study, we hypothesized the novel 3oc mediated crosstalk between autophagy and apoptosis at the interphase of calcium signaling in human macrophages. The study showed that 3oc induces mitochondrial dysfunction and apoptosis in macrophages through elevating cytosolic Ca

Topics: 4-Butyrolactone; Apoptosis; Autophagy; Beclin-1; Calcium; Calcium Signaling; Chelating Agents; Chloroquine; Egtazic Acid; Homoserine; Humans; Macrophages; Phosphatidylserines; Protein Kinases; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Reactive Oxygen Species; Sirolimus; Virulence Factors