sincalide and triciribine

A cholecystokinin (CCK) system has been identified in white adipose tissue (WAT). Nevertheless, the endocrine actions of CCK on WAT remain unknown. Our goal was to investigate the role of CCK in regulating the production of adiponectin, an adipokine expressed in WAT, which is pivotal in preserving energy homeostasis.. The effect of the bioactive CCK fragment CCK-8 on adiponectin production was studied both in vivo and in vitro. CCK-8 effects were characterized in rats treated with selective CCK. In WAT, CCK-8 increased plasma adiponectin levels and the expression of the adiponectin gene (Adipoq). In pre-adipocytes, CCK-8 up-regulated adiponectin production. CCK-8 effects were abolished by L-365,260, a selective CCK. CCK-8 stimulates adiponectin production in WAT by acting on CCK

Topics: Adipocytes; Adiponectin; Adipose Tissue, White; Animals; Benzamides; Cholecystokinin; Male; Peptide Fragments; PPAR gamma; Proto-Oncogene Proteins c-akt; Pyridines; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Ribonucleosides