sincalide and lysophosphatidylethanolamine

sincalide has been researched along with lysophosphatidylethanolamine* in 1 studies

Other Studies

1 other study(ies) available for sincalide and lysophosphatidylethanolamine

Article	Year
Increase in lysophosphatidylethanolamine in the cell membrane upon the regulated exocytosis of pancreatic acinar AR42J cells. Bioscience, biotechnology, and biochemistry, 1997, Volume: 61, Issue:1 A specific cytosolic phospholipase A2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3), was found to inhibit the regulated exocytosis of pancreatic acinar AR42J cells. When AR42J cells were stimulated with cholecystokinin octapeptide (CCK-8), the regulated exocytosis monitored by amylase release was rapidly activated and increased by 2.5-fold during one hour. After AR42J cells were treated with AACOCF3, amylase release by CCK-8 remained at the basal level. Thus, changes in the composition of membrane phospholipids before and after stimulation were investigated. Within 1 min after CCK-8 stimulation, lysophosphatidylethanolamine (lysoPE) in the cellular membranes of AR42J was increased while lysophosphatidylcholine stayed unchanged. In the presence of AACOCF3, lysoPE was not increased by CCK-8. Those results indicate that the increment of lysoPE is linked to the regulated exocytosis. Topics: Amylases; Animals; Arachidonic Acids; Cell Membrane; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Lysophospholipids; Membrane Lipids; Pancreas; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Sincalide	1997

Article

Year

Increase in lysophosphatidylethanolamine in the cell membrane upon the regulated exocytosis of pancreatic acinar AR42J cells.

Bioscience, biotechnology, and biochemistry, 1997, Volume: 61, Issue:1

A specific cytosolic phospholipase A2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3), was found to inhibit the regulated exocytosis of pancreatic acinar AR42J cells. When AR42J cells were stimulated with cholecystokinin octapeptide (CCK-8), the regulated exocytosis monitored by amylase release was rapidly activated and increased by 2.5-fold during one hour. After AR42J cells were treated with AACOCF3, amylase release by CCK-8 remained at the basal level. Thus, changes in the composition of membrane phospholipids before and after stimulation were investigated. Within 1 min after CCK-8 stimulation, lysophosphatidylethanolamine (lysoPE) in the cellular membranes of AR42J was increased while lysophosphatidylcholine stayed unchanged. In the presence of AACOCF3, lysoPE was not increased by CCK-8. Those results indicate that the increment of lysoPE is linked to the regulated exocytosis.

Topics: Amylases; Animals; Arachidonic Acids; Cell Membrane; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Lysophospholipids; Membrane Lipids; Pancreas; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Sincalide

1997