sincalide has been researched along with bemesetron* in 1 studies
1 other study(ies) available for sincalide and bemesetron
Article | Year |
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Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors.
To investigate the dependence of the satiating action of cholecystokinin on serotonergic function in rats, we examined the effects of systemic pretreatment with serotonin (5-HT) antagonists of varying selectivity for 5-HT receptor subtypes on suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CCK-8). Mianserin, a 5-HT1C/2-selective antagonist, significantly attenuated the satiating action of CCK-8. Ketanserin, a 5-HT2 antagonist, and three 5-HT3 antagonists, MDL-72222, ICS 205-930, and ondansetron, however, had no effect on the satiating action of CCK-8. These results demonstrate that the satiating action of exogenous CCK depends on activation of 5-HT1 (probably 5-HT1C) receptors and that activation of 5-HT2 or 5-HT3 receptors is not required. Topics: Animals; Eating; Ketanserin; Male; Mianserin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Satiation; Serotonin Antagonists; Sincalide; Tropanes | 1993 |