simvastatin has been researched along with geranylgeraniol in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Bernini, F; Bonfadini, G; Fumagalli, R; Scurati, N | 1 |
| Bellosta, S; Bernini, F; Bonfadini, G; Didoni, G; Fumagalli, R | 1 |
| Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR | 1 |
| Belloni, P; Corsini, A; Folco, G; Fumagalli, R; Granata, A; Hernandez, A; Paoletti, R; Viganõ, T | 1 |
| Colombo, C; Galli, C; Risé, P | 1 |
| Badimon, L; Llorente-Cortés, V; Martínez-González, J | 1 |
| Endres, M; Huang, P; Huang, Z; Laufs, U; Liao, JK; Moskowitz, MA; Nakamura, T | 1 |
| Fujita, H; Ishikawa, K; Morita, I; Murota, S; Shimotsuura, S; Yanagisawa, A | 1 |
| Ahmad, S; Ahmed, Z; Bhatia, V; Haskard, DO; Kinderlerer, A; Lidington, EA; Mankoff, R; Mason, JC; Randi, AM | 1 |
| Haslinger, B; Kleemann, R; Kooistra, T; Toet, KH | 1 |
| Deng, Y; DeRose, RA; Farber, SA; Ho, SY; Santana, E; Thorpe, JL | 1 |
| Galper, JB; Georgescu, SP; Hamilton, AD; Park, HJ; Sebti, SM; Tang, D | 1 |
| Alcudia, JF; Badimon, L; Guadall, A; Martínez-González, J; Raposo, B; Rodríguez, C; Sánchez-Gómez, S | 1 |
| Li, L; Mans, RA; McMahon, LL | 1 |
| Biondo, G; Castaldello, P; Corsini, A; Ferri, N; Lupo, MG; Marchianò, S; Trenti, A | 1 |
| Bouitbir, J; Krähenbühl, S; Sanvee, GM | 1 |
| Kitazaki, A; Ozawa, K; Yoshii, M | 1 |
18 other study(ies) available for simvastatin and geranylgeraniol
| Article | Year |
|---|---|
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages.
Topics: Animals; Carbocyanines; Cholesterol Esters; Diterpenes; Endocytosis; Fatty Acids, Monounsaturated; Fluorescent Dyes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Simvastatin | 1995 |
Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages.
Topics: Acetylation; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Cholesterol Esters; Diterpenes; Dose-Response Relationship, Drug; Esterification; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Simvastatin | 1993 |
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.
Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes | 1993 |
Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation.
Topics: Bronchi; Cell Division; Diterpenes; Enzyme Inhibitors; Humans; Lovastatin; Lung; Mevalonic Acid; Muscle, Smooth; Simvastatin | 1995 |
Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells.
Topics: Acetates; Cell Line; Cholesterol; Diterpenes; Enzyme Inhibitors; Esterification; Fatty Acids, Unsaturated; Glycerol; Glycolipids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Linoleic Acid; Linoleic Acids; Lipids; Lovastatin; Mevalonic Acid; Monocytes; Simvastatin | 1997 |
Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors.
Topics: Cells, Cultured; Cholesterol; Diterpenes; Esterification; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lipoproteins, LDL; Muscle, Smooth, Vascular; Simvastatin | 1998 |
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
Topics: Animals; Anticholesteremic Agents; Cells, Cultured; Diterpenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Lovastatin; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Simvastatin; Tumor Cells, Cultured; Up-Regulation | 1998 |
Simvastatin enhanced sodium nitroprusside-induced apoptosis of smooth muscle cells. An involvement of geranylgeraniol.
Topics: Animals; Apoptosis; Cattle; Cells, Cultured; Cholesterol; Diterpenes; Drug Synergism; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Rats; Simvastatin | 2000 |
Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury.
Topics: Atorvastatin; CD55 Antigens; Cell Line; Cells, Cultured; Complement Activation; Complement C3; Cytoprotection; Diterpenes; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Nitric Oxide; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Protein Kinase C; Pyrroles; rho GTP-Binding Proteins; RNA, Messenger; Simvastatin; Up-Regulation | 2002 |
Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells.
Topics: Antineoplastic Agents; Cells, Cultured; Diterpenes; Epithelial Cells; Epithelium; Fibrinolysis; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Omentum; Peritoneal Dialysis; Peritoneum; Peritonitis; Plasminogen Activator Inhibitor 1; Simvastatin; Thromboplastin; Tumor Necrosis Factor-alpha | 2003 |
Lipid metabolism in zebrafish.
Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish | 2004 |
Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
Topics: Apoptosis; Cell Membrane; Cells, Cultured; Diterpenes; E-Selectin; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mutation; Protein Prenylation; Receptors, Tumor Necrosis Factor, Type I; rhoA GTP-Binding Protein; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Veins; Up-Regulation | 2006 |
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
Topics: Animals; Atherosclerosis; Atorvastatin; Capillary Permeability; Cattle; Cells, Cultured; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Farnesol; Female; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, LDL; Protein Kinase C; Protein Kinase Inhibitors; Protein-Lysine 6-Oxidase; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Risk Factors; RNA, Messenger; Simvastatin; Swine; Transfection; Tumor Necrosis Factor-alpha | 2009 |
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.
Topics: Alkyl and Aryl Transferases; Animals; Blotting, Western; CA1 Region, Hippocampal; Diterpenes; Electrophysiological Phenomena; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Long-Term Potentiation; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Prenylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Simvastatin | 2012 |
Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1.
Topics: Anticholesteremic Agents; Caco-2 Cells; Diterpenes; Humans; Mevalonic Acid; Promoter Regions, Genetic; Proprotein Convertase 9; Protein Prenylation; rac1 GTP-Binding Protein; Signal Transduction; Simvastatin; Up-Regulation | 2017 |
C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation.
Topics: Animals; Anticholesteremic Agents; Cell Proliferation; Cell Survival; Diterpenes; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Random Allocation; Simvastatin | 2021 |
Effects of Simvastatin on RBL-2H3 Cell Degranulation.
Topics: Animals; Calcimycin; Calcium; Cell Degranulation; Mast Cells; Rats; Signal Transduction; Simvastatin | 2023 |