simethicone and aluminum-hydroxide--magnesium-hydroxide--drug-combination

Topics: Aluminum Hydroxide; Antacids; Anti-Ulcer Agents; Antifoaming Agents; Drug Combinations; Gastroesophageal Reflux; Gastroscopy; Humans; Magnesium Hydroxide; Ranitidine; Simethicone

Saxagliptin is an orally administered, highly potent, and selective dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus. This study was conducted to determine the effect of magnesium and aluminum hydroxides plus simethicone, famotidine, and omeprazole on the pharmacokinetics of saxagliptin and its active metabolite, 5-hydroxy saxagliptin. This was an open-label, randomized, 5-treatment, 5-period, 3-way crossover study in 15 healthy subjects. Mean C

Topics: Adamantane; Adult; Aluminum Hydroxide; Area Under Curve; Cross-Over Studies; Dipeptides; Drug Combinations; Drug Interactions; Famotidine; Female; Healthy Volunteers; Humans; Magnesium Hydroxide; Male; Metabolic Clearance Rate; Omeprazole; Simethicone; Young Adult

Four antacid preparations have been studied in a stratified, randomized, double-blind trial to evaluate criteria which determine patients' acceptance of this type of therapy. There was a considerable range of judgements about palatability, but preference was determined not only by factors such as the smell, taste, texture and after-taste of the preparation, but also by the order in which the antacids were tested and by the age and sex of the patient. The preparations also differed considerably in acid-neutralizing capacity and ability to bind bile salts, as well as cost. We conclude that individuals requiring antacid therapy should be allowed to chose from among a range of preparations, in order to maximize compliance.

Topics: Adult; Aged; Alginates; Aluminum Compounds; Aluminum Hydroxide; Aluminum Silicates; Antacids; Bicarbonates; Clinical Trials as Topic; Dimethylpolysiloxanes; Double-Blind Method; Drug Combinations; Esophagitis; Female; Humans; Magnesium; Magnesium Compounds; Magnesium Hydroxide; Magnesium Oxide; Male; Middle Aged; Patient Acceptance of Health Care; Peptic Ulcer; Random Allocation; Silicates; Silicic Acid; Silicon Dioxide; Silicones; Simethicone; Sodium Bicarbonate

Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis related to the underlying metabolic bone disease. The chronic use of aluminum-containing antacids in infants has potential risk for the growing skeleton and is not innocuous. Therefore, antacid therapy should be used in low doses and very cautiously, with routine monitoring of serum calcium and phosphorus in children taking medications which reduce gastrointestinal phosphate absorption.

Topics: Aluminum Hydroxide; Antacids; Colic; Drug Combinations; Female; Humans; Infant; Intestinal Absorption; Magnesium Hydroxide; Osteomalacia; Phosphates; Radiography; Rickets; Simethicone

Topics: Alkalosis; Aluminum Hydroxide; Drug Combinations; Humans; Magnesium; Magnesium Hydroxide; Male; Middle Aged; Silicones; Simethicone