Page last updated: 2024-08-23

silybin and silidianin

silybin has been researched along with silidianin in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (30.43)29.6817
2010's15 (65.22)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Anzenbacher, P; Dvorák, Z; Modrianský, M; Rohovský, P; Simánek, V; Ulrichová, J; Zuber, R1
Barrett, JS; Hsu, BH; Lee, JI; Wu, D1
Barrett, JS; Lee, JI; Narayan, M1
Chen, J; Lu, C; Lu, Y; Wu, W; Zhang, W1
Agarwal, R; Deep, G; Kroll, DJ; Oberlies, NH1
Fehér, J; Lengyel, G1
Hasanloo, T; Kazemi Tabar, SK; Khalili, M; Rahnama, H1
Chang, CH; Fang, JY; Hung, CF; Lin, YK; Zhang, LW1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Markowitz, JS; Patrick, KS; Zhu, HJ1
Ansari Jovini, M; Chaichi, MR; Hashemi, M; Jahanzad, E; Keshavarz Afshar, R1
Barba, FJ; Barth, D; Ben Rahal, N; Chevalot, I1
Biedermann, D; Biler, M; Křen, V; Kubala, M; Kuzma, M; Mojović, M; Popović-Bijelić, A; Pyszková, M; Sokolová, R; Trouillas, P; Ulrichová, J; Vacek, J; Valentová, K; Vrba, J1
Petersen, M; Poppe, L1
Fibigr, J; Šatínský, D; Solich, P1
AbouZid, SF; Ahmed, HS; Brent Friesen, J; Chen, SN; McAlpine, JB; Moawad, AS; Nachtergael, A; Owis, AI; Pauli, GF1
Biedermann, D; Dinkova-Kostova, AT; Křen, V; Roubalová, L; Ulrichová, J; Vrba, J1
Bijak, M; Saluk-Bijak, J1
Bijak, M; Dziedzic, A; Saluk-Bijak, J1
Bijak, M; Dziedzic, A; Saluk-Bijak, J; Sliwinski, T; Synowiec, E1
Bijak, M; Saluk-Bijak, J; Sitarek, P; Sliwiński, T; Synowiec, E1
Bijak, M; Dziedzic, A; Saluk-Bijak, J; Szelenberger, R1
Chen, Y; Li, H; Mao, X; Peng, Y; Wang, X; Yu, J; Zheng, J1
Kosina, P; Křen, V; Lněničková, K; Papoušková, B; Ulrichová, J; Vrba, J1

Reviews

1 review(s) available for silybin and silidianin

ArticleYear
[Silymarin in the treatment of chronic liver diseases: past and future].
    Orvosi hetilap, 2008, Dec-21, Volume: 149, Issue:51

    Topics: Antioxidants; Carcinoma, Hepatocellular; Chronic Disease; Colorectal Neoplasms; Fatty Liver; Fatty Liver, Alcoholic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Oxidative Stress; Silybin; Silymarin; Survival Analysis; Treatment Outcome

2008

Other Studies

22 other study(ies) available for silybin and silidianin

ArticleYear
Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.
    Phytotherapy research : PTR, 2002, Volume: 16, Issue:7

    Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Inhibitory Concentration 50; Isomerism; Liver; Microsomes, Liver; Phytotherapy; Plant Extracts; Silybin; Silybum marianum; Silymarin

2002
Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.
    Journal of chromatography. A, 2006, May-26, Volume: 1116, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Plant Extracts; Silybin; Silybum marianum; Silymarin; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2006
Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Jan-01, Volume: 845, Issue:1

    Topics: Chromatography, Liquid; Plant Extracts; Reproducibility of Results; Sensitivity and Specificity; Silybin; Silymarin; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry

2007
Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2007, Volume: 66, Issue:2

    Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Flavonols; Glycerides; Hemolysis; In Vitro Techniques; Molecular Structure; Poloxamer; Polyethylene Glycols; Protective Agents; Quercetin; Rabbits; Silybin; Silymarin; Solubility; Technology, Pharmaceutical; Time Factors

2007
Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
    International journal of cancer, 2008, Jul-01, Volume: 123, Issue:1

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Blotting, Western; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cyclins; Drug Screening Assays, Antitumor; Flavonolignans; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isomerism; Male; Prostatic Neoplasms; Protective Agents; Silybin; Silymarin; Time Factors

2008
Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.
    Cell biology international, 2009, Volume: 33, Issue:9

    Topics: Antioxidants; Cell Culture Techniques; Flavonolignans; Linoleic Acid; Lipoxygenase; Plant Roots; Quercetin; Salicylic Acid; Silybin; Silybum marianum; Silymarin

2009
Topical delivery of silymarin constituents via the skin route.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:1

    Topics: Administration, Cutaneous; Animals; Antioxidants; Diffusion Chambers, Culture; Female; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Mice, Nude; Permeability; Silybin; Silymarin; Skin Absorption; Skin Irritancy Tests; Thermodynamics; Time Factors

2010
An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:9

    Topics: Adult; Antioxidants; Dinoprost; F2-Isoprostanes; Female; Flavonolignans; Healthy Volunteers; Humans; Male; Silybin; Silybum marianum; Silymarin; Young Adult

2013
Accumulation of silymarin in milk thistle seeds under drought stress.
    Planta, 2015, Volume: 242, Issue:3

    Topics: Antioxidants; Droughts; Seeds; Silybin; Silybum marianum; Silymarin

2015
Supercritical CO₂ extraction of oil, fatty acids and flavonolignans from milk thistle seeds: Evaluation of their antioxidant and cytotoxic activities in Caco-2 cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 83

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Caco-2 Cells; Carcinoma; Cell Survival; Chromatography, Supercritical Fluid; Dietary Supplements; Fatty Acids; Flavonolignans; Food Additives; Humans; Plant Oils; Seeds; Silybin; Silybum marianum; Silymarin; Tunisia

2015
Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.
    Free radical biology & medicine, 2016, Volume: 90

    Topics: Animals; Antioxidants; Cytoprotection; Electron Spin Resonance Spectroscopy; Flavonolignans; Hep G2 Cells; Humans; Male; Rats; Silybin; Silymarin; Structure-Activity Relationship

2016
Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom.
    Phytochemistry, 2016, Volume: 131

    Topics: Bulgaria; Cells, Cultured; Europe; Flavonols; Fruit; Lignin; Quercetin; Silybin; Silybum marianum; Silymarin; Stereoisomerism

2016
A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase.
    Journal of pharmaceutical and biomedical analysis, 2017, Feb-05, Volume: 134

    Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dietary Supplements; Isomerism; Plant Extracts; Silybin; Silybum marianum; Silymarin; Teas, Herbal

2017
Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.
    Fitoterapia, 2017, Volume: 119

    Topics: Egypt; Flavonolignans; Fruit; Molecular Structure; Secondary Metabolism; Silybin; Silybum marianum; Silymarin

2017
Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.
    Fitoterapia, 2017, Volume: 119

    Topics: Animals; Cell Line, Tumor; Gene Expression; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Humans; Membrane Proteins; Mice; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Silybin; Silybum marianum; Silymarin; Up-Regulation

2017
Flavonolignans inhibit the arachidonic acid pathway in blood platelets.
    BMC complementary and alternative medicine, 2017, Aug-10, Volume: 17, Issue:1

    Topics: Anti-Inflammatory Agents; Arachidonic Acid; Binding, Competitive; Blood Platelets; Flavonolignans; Humans; Inflammation Mediators; Malondialdehyde; Molecular Docking Simulation; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Silybin; Silybum marianum; Silymarin; Thromboxane A2

2017
Flavonolignans reduce the response of blood platelet to collagen.
    International journal of biological macromolecules, 2018, Volume: 106

    Topics: Blood Coagulation; Blood Platelets; Cell Adhesion; Collagen; Flavonolignans; Hemostatics; Humans; Platelet Activation; Platelet Aggregation; Platelet Factor 4; Platelet Glycoprotein GPIIb-IIIa Complex; Silybin; Silymarin

2018
Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and Leukocytes.
    Nutrients, 2017, Sep-15, Volume: 9, Issue:9

    Topics: Anti-Inflammatory Agents; Blood Platelets; Cells, Cultured; Cytokines; Flavonolignans; Humans; Interleukin-1beta; Leukocytes; Platelet Aggregation Inhibitors; Silybin; Silymarin

2017
Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models.
    Nutrients, 2017, Dec-14, Volume: 9, Issue:12

    Topics: A549 Cells; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Blood Platelets; Cell Survival; DNA Copy Number Variations; DNA Damage; DNA, Mitochondrial; Dose-Response Relationship, Drug; Flavonolignans; Fruit; Humans; Leukocytes, Mononuclear; Plant Extracts; Reactive Oxygen Species; Silybin; Silybum marianum; Silymarin

2017
Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets.
    Molecules (Basel, Switzerland), 2018, Feb-10, Volume: 23, Issue:2

    Topics: Adenosine Diphosphate; Blood Platelets; Cell Adhesion Molecules; Fibrinogen; Flavonolignans; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet-Rich Plasma; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Silybin; Silymarin

2018
Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:11

    Topics: Animals; Cytochrome P-450 Enzyme System; Glutathione; Humans; Hydroxylation; Isomerism; Microsomes, Liver; Oxidation-Reduction; Rats; Silybin; Silymarin; Tandem Mass Spectrometry

2019
Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.
    Journal of pharmaceutical and biomedical analysis, 2020, Jan-30, Volume: 178

    Topics: Adult; Cells, Cultured; Flavonolignans; Glucuronides; Glucuronosyltransferase; Hepatocytes; Humans; Male; Microsomes, Liver; Silybin; Silybum marianum; Silymarin

2020