Page last updated: 2024-08-23

silybin and isosilybin a

silybin has been researched along with isosilybin a in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (5.26)	29.6817
2010's	17 (89.47)	24.3611
2020's	1 (5.26)	2.80

Authors

Authors	Studies
Bednárová, L; Gažák, R; Kuzma, M; Novák, P; Stodůlková, E; Šulc, M; Vimberg, V	1
Baiseitova, A; Ban, YJ; Jenis, J; Kim, JY; Li, ZP; Park, KH	1
Matsuda, H; Nakamura, S; Nakashima, S; Oda, Y; Xu, F; Yoshikawa, M	1
Brouwer, KL; Hawke, RL; Köck, K; Oberlies, NH; Xie, Y	1
Althagafy, HS; Croatt, MP; Graf, TN; Gufford, BT; Oberlies, NH; Paine, MF; Polyak, SJ; Sy-Cordero, AA; Wagoner, J	1
Atanasov, AG; Bauer, R; Dirsch, VM; Heiss, EH; Kunert, O; Malainer, C; Noha, SM; Oberlies, NH; Pferschy-Wenzig, EM; Schuster, D; Wagner, H	1
Agarwal, R; Deep, G; Kroll, DJ; Oberlies, NH	1
Brantley, SJ; Kroll, DJ; Oberlies, NH; Paine, MF	1
Agarwal, C; Agarwal, R; Deep, G; Gangar, SC; Gu, M; Oberlies, NH; Raina, K; Rajamanickam, S	1
Day, CS; Oberlies, NH; Sy-Cordero, AA	1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Markowitz, JS; Patrick, KS; Zhu, HJ	1
Cech, NB; El-Elimat, T; Faeth, SH; Graf, TN; Oberlies, NH; Raja, HA	1
Bernstein, HJ; Brinda, BJ; Chavin, KD; Frye, RF; Kawaguchi-Suzuki, M; Markowitz, JS; Zhu, HJ	1
Petersen, M; Poppe, L	1
Fibigr, J; Šatínský, D; Solich, P	1
AbouZid, SF; Ahmed, HS; Brent Friesen, J; Chen, SN; McAlpine, JB; Moawad, AS; Nachtergael, A; Owis, AI; Pauli, GF	1
Biedermann, D; Křen, V; Papoušková, B; Roubalová, L; Ulrichová, J; Vacek, J; Valentová, K; Vrba, J; Zatloukalová, M	1
Chen, Y; Li, H; Mao, X; Peng, Y; Wang, X; Yu, J; Zheng, J	1
Kosina, P; Křen, V; Lněničková, K; Papoušková, B; Ulrichová, J; Vrba, J	1

Trials

1 trial(s) available for silybin and isosilybin a

Article	Year
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10 Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult	2014

Article

Year

The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.

Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10

Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult

2014

Other Studies

18 other study(ies) available for silybin and isosilybin a

Article	Year
Hydnocarpin-Type Flavonolignans: Semisynthesis and Inhibitory Effects on Staphylococcus aureus Biofilm Formation. Journal of natural products, 2015, Aug-28, Volume: 78, Issue:8 Topics: Antioxidants; Biofilms; Chromatography, High Pressure Liquid; Flavonolignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Silybum marianum; Silymarin; Staphylococcus aureus; Structure-Activity Relationship	2015
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorganic & medicinal chemistry, 2019, 06-15, Volume: 27, Issue:12 Topics: Chromatography, High Pressure Liquid; Flavonoids; Kinetics; Monophenol Monooxygenase; Oxidation-Reduction; Plant Extracts; Seeds; Silybum marianum; Silymarin; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tyrosine	2019
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Agaricales; Animals; Antineoplastic Agents; Brassicaceae; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Intramolecular Oxidoreductases; Melanoma, Experimental; Membrane Glycoproteins; Mice; Monophenol Monooxygenase; Oxidoreductases; Plant Extracts; RNA, Messenger; Structure-Activity Relationship; Tumor Cells, Cultured	2010
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Fluorobenzenes; HEK293 Cells; Hepatocytes; Humans; Organic Anion Transporters; Pyrimidines; Rosuvastatin Calcium; Silymarin; Sulfonamides	2013
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle. Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13 Topics: Antiviral Agents; Aryl Hydrocarbon Hydroxylases; Cell Line; Cell Survival; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Humans; Methylation; Microsomes; Silybum marianum; Silymarin	2013
Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. Journal of natural products, 2014, Apr-25, Volume: 77, Issue:4 Topics: Adipocytes; Benzamides; Dose-Response Relationship, Drug; Liver Diseases; Molecular Structure; PPAR gamma; Pyridines; Receptors, Cytoplasmic and Nuclear; Seeds; Silybum marianum; Silymarin; Stereoisomerism	2014
Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. International journal of cancer, 2008, Jul-01, Volume: 123, Issue:1 Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Blotting, Western; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cyclins; Drug Screening Assays, Antitumor; Flavonolignans; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isomerism; Male; Prostatic Neoplasms; Protective Agents; Silybin; Silymarin; Time Factors	2008
Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3 Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Herb-Drug Interactions; Humans; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Recombinant Proteins; Silybin; Silybum marianum; Silymarin; Stereoisomerism; Warfarin	2010
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling. PloS one, 2012, Volume: 7, Issue:4 Topics: Animals; Cell Line; Cell Line, Tumor; Flavonolignans; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Silybin; Silybum marianum; Silymarin; Xenograft Model Antitumor Assays	2012
Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-Bromobenzoyl)isosilybin A. Journal of natural products, 2012, Nov-26, Volume: 75, Issue:11 Topics: Circular Dichroism; Crystallography, X-Ray; Flavanones; Flavonolignans; Fruit; Molecular Conformation; Molecular Structure; Silybin; Silybum marianum; Silymarin; Stereoisomerism	2012
An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:9 Topics: Adult; Antioxidants; Dinoprost; F2-Isoprostanes; Female; Flavonolignans; Healthy Volunteers; Humans; Male; Silybin; Silybum marianum; Silymarin; Young Adult	2013
Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum). Journal of natural products, 2014, Feb-28, Volume: 77, Issue:2 Topics: Aspergillus; Flavonolignans; Fruit; Molecular Structure; Silybin; Silybum marianum; Silymarin	2014
Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom. Phytochemistry, 2016, Volume: 131 Topics: Bulgaria; Cells, Cultured; Europe; Flavonols; Fruit; Lignin; Quercetin; Silybin; Silybum marianum; Silymarin; Stereoisomerism	2016
A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase. Journal of pharmaceutical and biomedical analysis, 2017, Feb-05, Volume: 134 Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dietary Supplements; Isomerism; Plant Extracts; Silybin; Silybum marianum; Silymarin; Teas, Herbal	2017
Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations. Fitoterapia, 2017, Volume: 119 Topics: Egypt; Flavonolignans; Fruit; Molecular Structure; Secondary Metabolism; Silybin; Silybum marianum; Silymarin	2017
Metabolism of flavonolignans in human hepatocytes. Journal of pharmaceutical and biomedical analysis, 2018, Apr-15, Volume: 152 Topics: Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Flavonolignans; Hepatocytes; Humans; Male; Middle Aged; Silybin; Silymarin; Tandem Mass Spectrometry	2018
Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:11 Topics: Animals; Cytochrome P-450 Enzyme System; Glutathione; Humans; Hydroxylation; Isomerism; Microsomes, Liver; Oxidation-Reduction; Rats; Silybin; Silymarin; Tandem Mass Spectrometry	2019
Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans. Journal of pharmaceutical and biomedical analysis, 2020, Jan-30, Volume: 178 Topics: Adult; Cells, Cultured; Flavonolignans; Glucuronides; Glucuronosyltransferase; Hepatocytes; Humans; Male; Microsomes, Liver; Silybin; Silybum marianum; Silymarin	2020