silybin has been researched along with isosilybin a in 19 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (5.26) | 29.6817 |
2010's | 17 (89.47) | 24.3611 |
2020's | 1 (5.26) | 2.80 |
Authors | Studies |
---|---|
Bednárová, L; Gažák, R; Kuzma, M; Novák, P; Stodůlková, E; Šulc, M; Vimberg, V | 1 |
Baiseitova, A; Ban, YJ; Jenis, J; Kim, JY; Li, ZP; Park, KH | 1 |
Matsuda, H; Nakamura, S; Nakashima, S; Oda, Y; Xu, F; Yoshikawa, M | 1 |
Brouwer, KL; Hawke, RL; Köck, K; Oberlies, NH; Xie, Y | 1 |
Althagafy, HS; Croatt, MP; Graf, TN; Gufford, BT; Oberlies, NH; Paine, MF; Polyak, SJ; Sy-Cordero, AA; Wagoner, J | 1 |
Atanasov, AG; Bauer, R; Dirsch, VM; Heiss, EH; Kunert, O; Malainer, C; Noha, SM; Oberlies, NH; Pferschy-Wenzig, EM; Schuster, D; Wagner, H | 1 |
Agarwal, R; Deep, G; Kroll, DJ; Oberlies, NH | 1 |
Brantley, SJ; Kroll, DJ; Oberlies, NH; Paine, MF | 1 |
Agarwal, C; Agarwal, R; Deep, G; Gangar, SC; Gu, M; Oberlies, NH; Raina, K; Rajamanickam, S | 1 |
Day, CS; Oberlies, NH; Sy-Cordero, AA | 1 |
Bernstein, HJ; Brinda, BJ; Chavin, KD; Markowitz, JS; Patrick, KS; Zhu, HJ | 1 |
Cech, NB; El-Elimat, T; Faeth, SH; Graf, TN; Oberlies, NH; Raja, HA | 1 |
Bernstein, HJ; Brinda, BJ; Chavin, KD; Frye, RF; Kawaguchi-Suzuki, M; Markowitz, JS; Zhu, HJ | 1 |
Petersen, M; Poppe, L | 1 |
Fibigr, J; Šatínský, D; Solich, P | 1 |
AbouZid, SF; Ahmed, HS; Brent Friesen, J; Chen, SN; McAlpine, JB; Moawad, AS; Nachtergael, A; Owis, AI; Pauli, GF | 1 |
Biedermann, D; Křen, V; Papoušková, B; Roubalová, L; Ulrichová, J; Vacek, J; Valentová, K; Vrba, J; Zatloukalová, M | 1 |
Chen, Y; Li, H; Mao, X; Peng, Y; Wang, X; Yu, J; Zheng, J | 1 |
Kosina, P; Křen, V; Lněničková, K; Papoušková, B; Ulrichová, J; Vrba, J | 1 |
1 trial(s) available for silybin and isosilybin a
Article | Year |
---|---|
The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.
Topics: Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dietary Supplements; Female; Herb-Drug Interactions; Humans; Male; Midazolam; Plant Extracts; Silybin; Silybum marianum; Silymarin; Tolbutamide; Young Adult | 2014 |
18 other study(ies) available for silybin and isosilybin a
Article | Year |
---|---|
Hydnocarpin-Type Flavonolignans: Semisynthesis and Inhibitory Effects on Staphylococcus aureus Biofilm Formation.
Topics: Antioxidants; Biofilms; Chromatography, High Pressure Liquid; Flavonolignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Silybum marianum; Silymarin; Staphylococcus aureus; Structure-Activity Relationship | 2015 |
Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle).
Topics: Chromatography, High Pressure Liquid; Flavonoids; Kinetics; Monophenol Monooxygenase; Oxidation-Reduction; Plant Extracts; Seeds; Silybum marianum; Silymarin; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tyrosine | 2019 |
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
Topics: Agaricales; Animals; Antineoplastic Agents; Brassicaceae; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Intramolecular Oxidoreductases; Melanoma, Experimental; Membrane Glycoproteins; Mice; Monophenol Monooxygenase; Oxidoreductases; Plant Extracts; RNA, Messenger; Structure-Activity Relationship; Tumor Cells, Cultured | 2010 |
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Topics: Fluorobenzenes; HEK293 Cells; Hepatocytes; Humans; Organic Anion Transporters; Pyrimidines; Rosuvastatin Calcium; Silymarin; Sulfonamides | 2013 |
Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Topics: Antiviral Agents; Aryl Hydrocarbon Hydroxylases; Cell Line; Cell Survival; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Drug Interactions; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Humans; Methylation; Microsomes; Silybum marianum; Silymarin | 2013 |
Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma.
Topics: Adipocytes; Benzamides; Dose-Response Relationship, Drug; Liver Diseases; Molecular Structure; PPAR gamma; Pyridines; Receptors, Cytoplasmic and Nuclear; Seeds; Silybum marianum; Silymarin; Stereoisomerism | 2014 |
Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Blotting, Western; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cyclins; Drug Screening Assays, Antitumor; Flavonolignans; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isomerism; Male; Prostatic Neoplasms; Protective Agents; Silybin; Silymarin; Time Factors | 2008 |
Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Herb-Drug Interactions; Humans; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Recombinant Proteins; Silybin; Silybum marianum; Silymarin; Stereoisomerism; Warfarin | 2010 |
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.
Topics: Animals; Cell Line; Cell Line, Tumor; Flavonolignans; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Silybin; Silybum marianum; Silymarin; Xenograft Model Antitumor Assays | 2012 |
Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-Bromobenzoyl)isosilybin A.
Topics: Circular Dichroism; Crystallography, X-Ray; Flavanones; Flavonolignans; Fruit; Molecular Conformation; Molecular Structure; Silybin; Silybum marianum; Silymarin; Stereoisomerism | 2012 |
An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
Topics: Adult; Antioxidants; Dinoprost; F2-Isoprostanes; Female; Flavonolignans; Healthy Volunteers; Humans; Male; Silybin; Silybum marianum; Silymarin; Young Adult | 2013 |
Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).
Topics: Aspergillus; Flavonolignans; Fruit; Molecular Structure; Silybin; Silybum marianum; Silymarin | 2014 |
Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom.
Topics: Bulgaria; Cells, Cultured; Europe; Flavonols; Fruit; Lignin; Quercetin; Silybin; Silybum marianum; Silymarin; Stereoisomerism | 2016 |
A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dietary Supplements; Isomerism; Plant Extracts; Silybin; Silybum marianum; Silymarin; Teas, Herbal | 2017 |
Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.
Topics: Egypt; Flavonolignans; Fruit; Molecular Structure; Secondary Metabolism; Silybin; Silybum marianum; Silymarin | 2017 |
Metabolism of flavonolignans in human hepatocytes.
Topics: Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Flavonolignans; Hepatocytes; Humans; Male; Middle Aged; Silybin; Silymarin; Tandem Mass Spectrometry | 2018 |
Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers.
Topics: Animals; Cytochrome P-450 Enzyme System; Glutathione; Humans; Hydroxylation; Isomerism; Microsomes, Liver; Oxidation-Reduction; Rats; Silybin; Silymarin; Tandem Mass Spectrometry | 2019 |
Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.
Topics: Adult; Cells, Cultured; Flavonolignans; Glucuronides; Glucuronosyltransferase; Hepatocytes; Humans; Male; Microsomes, Liver; Silybin; Silybum marianum; Silymarin | 2020 |