silybin has been researched along with acetaminophen in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campos, R; Garrido, A; Guerra, R; Valenzuela, A | 2 |
| El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E | 1 |
| Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A | 1 |
| Liu, X; Wang, Q; Xu, R; Yang, J; Zang, M; Zhang, J | 1 |
| Deshpande, P; Jain, P; Kumar, N; Kutty, NG; Mathew, G; Rai, A; Raj, PV; Rao, CM; Reddy, ND; Udupa, N | 1 |
| Ding, Y; Ge, Y; Sun, Z; Tong, Z; Wang, W; Xu, Q; Zhang, S; Zhou, H; Zhou, L | 1 |
| Alavizadeh, SH; Doagooyan, M; Gheybi, F; Hoseinian, A; Houshangi, K; Jaafari, MR; Khoddamipour, Z; Khooei, A; Papi, A; Sahebkar, A | 1 |
9 other study(ies) available for silybin and acetaminophen
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver.
Topics: Acetaminophen; Animals; Flavonoids; Glutathione; Lipid Peroxidation; Liver; Male; Rats; Rats, Inbred Strains; Silybin; Silymarin | 1989 |
Acetaminophen hepatotoxicity in rats is attenuated by silybin dihemisuccinate.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Liver Diseases; Male; Rats; Rats, Inbred Strains; Silybin; Silymarin | 1988 |
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts | 2003 |
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Liver; Magnetic Resonance Spectroscopy; Male; Rabbits; Silybin; Silymarin | 2009 |
Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Glycyrrhizic Acid; Hepatobiliary Elimination; Injections, Intraperitoneal; Liver; Male; Rats, Sprague-Dawley; Silybin; Silymarin; Spironolactone; Time Factors | 2014 |
Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells.
Topics: Acetaminophen; Administration, Oral; Animals; Biological Availability; Cell Line; Chemical and Drug Induced Liver Injury; Drug Liberation; Hepatocytes; Humans; Hydrogen-Ion Concentration; Lipopolysaccharides; Liposomes; Liver; Macrophages; Male; Mice; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Silybin; Silymarin | 2014 |
Preclinical validation of silibinin/albumin nanoparticles as an applicable system against acute liver injury.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Galactosamine; Lipopolysaccharides; Liver; Mice; Nanoparticles; Serum Albumin, Bovine; Silybin | 2022 |
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Lipids; Liposomes; Liver; Liver Failure; Mice; NIH 3T3 Cells; Reactive Oxygen Species; Silybin | 2023 |