silicon and streptazolin

silicon has been researched along with streptazolin* in 1 studies

Other Studies

1 other study(ies) available for silicon and streptazolin

Article	Year
Stereoselective total synthesis of (+)-streptazolin by using a temporary silicon-tethered RCM strategy. The Journal of organic chemistry, 2006, Jul-07, Volume: 71, Issue:14 A stereoselective total synthesis of (+)-streptazolin 1 was accomplished starting from readily available aminocyclopentenol (-)-7. The synthetic sequence highlights an intramolecular aldol condensation strategy to construct the piperidine core and a silicon-tethered ring-closing metathesis strategy to install the Z exocyclic ethylidene side chain of streptazolin. Separate protodesilylation and Tamao oxidation of a common intermediate 32 afforded streptazolin and the precursor for 13-hydroxystreptazolin. The overall yield for (+)-streptazolin 1 from aminocyclopentenol (-)-7 was 4.8% for a total of 16 steps. Topics: Cyclization; Cyclopentanes; Molecular Conformation; Oxidation-Reduction; Piperidines; Silicon; Stereoisomerism	2006

Article

Year

Stereoselective total synthesis of (+)-streptazolin by using a temporary silicon-tethered RCM strategy.

The Journal of organic chemistry, 2006, Jul-07, Volume: 71, Issue:14

A stereoselective total synthesis of (+)-streptazolin 1 was accomplished starting from readily available aminocyclopentenol (-)-7. The synthetic sequence highlights an intramolecular aldol condensation strategy to construct the piperidine core and a silicon-tethered ring-closing metathesis strategy to install the Z exocyclic ethylidene side chain of streptazolin. Separate protodesilylation and Tamao oxidation of a common intermediate 32 afforded streptazolin and the precursor for 13-hydroxystreptazolin. The overall yield for (+)-streptazolin 1 from aminocyclopentenol (-)-7 was 4.8% for a total of 16 steps.

Topics: Cyclization; Cyclopentanes; Molecular Conformation; Oxidation-Reduction; Piperidines; Silicon; Stereoisomerism

2006