silicon and hydrazoic-acid

silicon has been researched along with hydrazoic-acid* in 1 studies

Reviews

1 review(s) available for silicon and hydrazoic-acid

Article	Year
5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods. Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:11 5-Substituted-1H-tetrazoles (RCN4H) are often used as metabolism-resistant isosteric replacements for carboxylic acids (RCO2H) in SAR-driven medicinal chemistry analogue syntheses. This review provides a brief summary of the medicinal chemistry of tetrazolic acids and highlights some examples of tetrazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 5-substituted-1H-tetrazoles, focusing on preparations from aryl and alkyl nitriles, is presented in sections by generalized synthetic methods. Topics: Animals; Azides; Carboxylic Acids; Chemistry, Pharmaceutical; Humans; Isomerism; Silicon; Tetrazoles; Tin	2002

Article

Year

5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods.

Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:11

5-Substituted-1H-tetrazoles (RCN4H) are often used as metabolism-resistant isosteric replacements for carboxylic acids (RCO2H) in SAR-driven medicinal chemistry analogue syntheses. This review provides a brief summary of the medicinal chemistry of tetrazolic acids and highlights some examples of tetrazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 5-substituted-1H-tetrazoles, focusing on preparations from aryl and alkyl nitriles, is presented in sections by generalized synthetic methods.

Topics: Animals; Azides; Carboxylic Acids; Chemistry, Pharmaceutical; Humans; Isomerism; Silicon; Tetrazoles; Tin

2002