silicon and 2-naphthylacetic-acid

silicon has been researched along with 2-naphthylacetic-acid* in 1 studies

Other Studies

1 other study(ies) available for silicon and 2-naphthylacetic-acid

Article	Year
Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs. Rapid communications in mass spectrometry : RCM, 2003, Volume: 17, Issue:12 The feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) for drug analysis was investigated. It was observed that only compounds with relative high proton affinity are efficiently ionized under AP-DIOS conditions. The limits of detection (LODs) achieved in MS mode with midazolam, propranolol, and angiotensin II were 80 fmol, 20 pmol, and 1 pmol, respectively. In MS/MS mode the LODs for midazolam and propranolol were 10 fmol and 5 pmol, respectively. The good linearity (r(2) > 0.991), linear dynamic range of 3 orders of magnitude, and reasonable repeatability showed that the method is suitable for quantitative analysis. Topics: Acetaminophen; Air Ionization; Atmospheric Pressure; Carboxylic Acids; Ketoprofen; Mass Spectrometry; Midazolam; Molecular Structure; Naphthaleneacetic Acids; Naphthalenes; Naphthoquinones; Pharmaceutical Preparations; Propranolol; Silicon; Testosterone	2003

Article

Year

Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs.

Rapid communications in mass spectrometry : RCM, 2003, Volume: 17, Issue:12

The feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) for drug analysis was investigated. It was observed that only compounds with relative high proton affinity are efficiently ionized under AP-DIOS conditions. The limits of detection (LODs) achieved in MS mode with midazolam, propranolol, and angiotensin II were 80 fmol, 20 pmol, and 1 pmol, respectively. In MS/MS mode the LODs for midazolam and propranolol were 10 fmol and 5 pmol, respectively. The good linearity (r(2) > 0.991), linear dynamic range of 3 orders of magnitude, and reasonable repeatability showed that the method is suitable for quantitative analysis.

Topics: Acetaminophen; Air Ionization; Atmospheric Pressure; Carboxylic Acids; Ketoprofen; Mass Spectrometry; Midazolam; Molecular Structure; Naphthaleneacetic Acids; Naphthalenes; Naphthoquinones; Pharmaceutical Preparations; Propranolol; Silicon; Testosterone

2003