silicon and 2-ethylidene-1-5-dimethyl-3-3-diphenylpyrrolidine

silicon has been researched along with 2-ethylidene-1-5-dimethyl-3-3-diphenylpyrrolidine* in 1 studies

Other Studies

1 other study(ies) available for silicon and 2-ethylidene-1-5-dimethyl-3-3-diphenylpyrrolidine

Article	Year
Porous silicon mass spectrometry as an alternative confirmatory assay for compliance testing of methadone. Drug testing and analysis, 2017, Volume: 9, Issue:5 Porous silicon based surface-assisted laser desorption ionization mass spectrometry (pSi SALDI-MS) is an analytical technique well suited for high throughput analysis of low molecular weight compounds from biological samples. A potential application of this technology is the compliance monitoring of opioid addiction programmes, where methadone is used as a pharmacological treatment for drugs such as heroin. Here, we present the detection and quantification of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) from water and clinical samples (saliva, urine, and plasma) from opioid dependent participants using pSi SALDI-MS. A one-step solvent phase extraction using chloroform was developed for the detection of methadone from clinical samples for analysis by pSi SALDI-MS. Liquid chromatography-mass spectrometry (LC-MS) was used as a comparative technique for the quantification of methadone from clinical saliva and plasma samples. In all cases, we obtained a good correlation of pSi SALDI-MS and LC-MS results, suggesting that pSi SALDI-MS may be an alternative procedure for high-throughput screening and quantification for application in opioid compliance testing. Copyright © 2016 John Wiley & Sons, Ltd. Topics: Adolescent; Adult; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Middle Aged; Narcotics; Porosity; Pyrrolidines; Reproducibility of Results; Saliva; Silicon; Substance Abuse Detection; Water; Young Adult	2017

Article

Year

Porous silicon mass spectrometry as an alternative confirmatory assay for compliance testing of methadone.

Drug testing and analysis, 2017, Volume: 9, Issue:5

Porous silicon based surface-assisted laser desorption ionization mass spectrometry (pSi SALDI-MS) is an analytical technique well suited for high throughput analysis of low molecular weight compounds from biological samples. A potential application of this technology is the compliance monitoring of opioid addiction programmes, where methadone is used as a pharmacological treatment for drugs such as heroin. Here, we present the detection and quantification of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) from water and clinical samples (saliva, urine, and plasma) from opioid dependent participants using pSi SALDI-MS. A one-step solvent phase extraction using chloroform was developed for the detection of methadone from clinical samples for analysis by pSi SALDI-MS. Liquid chromatography-mass spectrometry (LC-MS) was used as a comparative technique for the quantification of methadone from clinical saliva and plasma samples. In all cases, we obtained a good correlation of pSi SALDI-MS and LC-MS results, suggesting that pSi SALDI-MS may be an alternative procedure for high-throughput screening and quantification for application in opioid compliance testing. Copyright © 2016 John Wiley & Sons, Ltd.

Topics: Adolescent; Adult; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Middle Aged; Narcotics; Porosity; Pyrrolidines; Reproducibility of Results; Saliva; Silicon; Substance Abuse Detection; Water; Young Adult

2017