silicon and 2-2-dimethyl-4-(chloromethyl)-1-3-dioxa-2-silacyclopentane

Male adult Wistar rats were treated for 8 weeks with an organosilicone [2,2-dimethyl-4-(chloromethyl)-1,3-dioxa-2-silacyclopentane] employing two different dosages (25 and 50 mg/kg body weight i.p. daily) and the changes in the tubular apparatus of the kidney were investigated employing histological and enzyme-histochemical methods. The effects, more pronounced at the higher dosage, were the following: The brush borders of the proximal tubules were stuck together and disintegrated; only few epithelial cells remained intact showing a decreased activity of nonspecific esterases and the increase of beta-hydroxybutyric acid dehydrogenase. The nuclei of most of the epithelial cells in the distal tubules were dislocated towards the enlarged lumen and the cytoplasma showed a decrease of nonspecific esterases and an increase of beta-hydroxybutyric acid dehydrogenase. The collagen fibers in the walls of the collecting tubules were dislocated and disintegrated with a discontinuous border of Mg2+-ATPase; the nuclei of the epithelial cells were pyknotic, the cytoplasma showed an increase of beta-hydroxybutyric acid dehydrogenase. The induced changes were partially reversible after a recovery period of 8 weeks.

Topics: Animals; Ca(2+) Mg(2+)-ATPase; Cyclopentanes; Esterases; Hydroxybutyrate Dehydrogenase; Kidney Tubules; Kidney Tubules, Collecting; Kidney Tubules, Distal; Kidney Tubules, Proximal; Male; Organosilicon Compounds; Rats; Rats, Inbred Strains; Silicon

Topics: 3-Hydroxysteroid Dehydrogenases; Alkaline Phosphatase; Animals; Ca(2+) Mg(2+)-ATPase; Carboxylesterase; Carboxylic Ester Hydrolases; Cyclopentanes; Histocytochemistry; L-Lactate Dehydrogenase; Male; Organosilicon Compounds; Rats; Rats, Inbred Strains; Silicon; Spermatids; Spermatozoa; Testis

The effects of an organosilicon compound SOC, a derivative of 1,3-dioxa-2-sila-cyclopentane, on rat spermiogenesis were studied with the help of histochemical and enzyme histochemical methods. The rats were injected with SOC i.p. daily for 3 weeks (dosage: 25 mg SOC/kg body weight). Two changes were observed: a) formation of a distinct vacuole within the acrosomal cap of spermatids b) the splitting of the tails of mature sperms.

Topics: Acrosome; Animals; Cyclopentanes; Male; Organosilicon Compounds; Rats; Rats, Inbred Strains; Silicon; Sperm Tail; Spermatids; Spermatogenesis; Spermatozoa; Vacuoles

Topics: Animals; Cyclopentanes; Kidney; Lethal Dose 50; Liver; Male; Organosilicon Compounds; Rats; Silicon; Testis