silicon and 2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid

silicon has been researched along with 2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid* in 2 studies

Other Studies

2 other study(ies) available for silicon and 2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid

Article	Year
Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study. European journal of pharmacology, 2017, Nov-05, Volume: 814 There are many chronic diseases related with inflammation. The chronic inflammation can produce other problems as cancer. Therefore, it is necessary to design drugs with better anti-inflammatory activity than those in the clinic. Likewise, these could be used in chronic treatments with minimum adverse effects. The amide or ester functionality in combination with the insertion of a silyl alkyl moiety is able to improve some drug properties. In this context, the evaluation of a group of silicon containing ibuprofen derivatives (SCIDs) as antioxidants and anti-inflammatory agents is reported. Antioxidant activity was evaluated by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH⨪), 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Ibuprofen; Iron Chelating Agents; Male; Molecular Docking Simulation; Picrates; Rats; Rats, Wistar; Silicon; Sulfonic Acids	2017
Optical biosensor based on hollow integrated waveguides. Analytical chemistry, 2008, May-01, Volume: 80, Issue:9 The first absorbance biosensor based on pure silicon hollow integrated waveguides is presented in this work. With the use of horseradish peroxidase (HRP) as a model recognition element, an enzymatic sensor for the measurement of hydrogen peroxide was fabricated, numerically simulated, and experimentally characterized. Waveguides with widths ranging from 50 to 80 microm, having a depth of 50 microm and lengths up to 5 mm were easily fabricated by just one photolithographic step. These were further modified by covalent immobilization of HRP using silanization chemistry. Simulation studies of the proposed approach showed a sensor linear behavior up to 300 microM H2O2 and a sensitivity of 2.7 x 10(-3) AU/microM. Experimental results were in good agreement with the simulated ones. A linear behavior between 10 and 300 microM H2O2, a sensitivity of 3 x 10(-3) AU/microM, and a signal-to-noise ratio around 20 dB were attained. Also, kinetic studies of the activity of the immobilized enzyme on the silicon waveguide surface gave an apparent Michaelis-Menten constant of 0.44 mM. The simple technology proposed in this work enables the fabrication of cost-effective, easy-to-use, miniaturized biosensor generic platforms, these being envisioned as excellent candidates for the development of lab-on-a-chip systems. Topics: Benzothiazoles; Biosensing Techniques; Enzymes, Immobilized; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Microfluidic Analytical Techniques; Optics and Photonics; Silicon; Sulfonic Acids	2008

Article

Year

Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study.

European journal of pharmacology, 2017, Nov-05, Volume: 814

There are many chronic diseases related with inflammation. The chronic inflammation can produce other problems as cancer. Therefore, it is necessary to design drugs with better anti-inflammatory activity than those in the clinic. Likewise, these could be used in chronic treatments with minimum adverse effects. The amide or ester functionality in combination with the insertion of a silyl alkyl moiety is able to improve some drug properties. In this context, the evaluation of a group of silicon containing ibuprofen derivatives (SCIDs) as antioxidants and anti-inflammatory agents is reported. Antioxidant activity was evaluated by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH⨪), 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Ibuprofen; Iron Chelating Agents; Male; Molecular Docking Simulation; Picrates; Rats; Rats, Wistar; Silicon; Sulfonic Acids

2017

Optical biosensor based on hollow integrated waveguides.

Analytical chemistry, 2008, May-01, Volume: 80, Issue:9

The first absorbance biosensor based on pure silicon hollow integrated waveguides is presented in this work. With the use of horseradish peroxidase (HRP) as a model recognition element, an enzymatic sensor for the measurement of hydrogen peroxide was fabricated, numerically simulated, and experimentally characterized. Waveguides with widths ranging from 50 to 80 microm, having a depth of 50 microm and lengths up to 5 mm were easily fabricated by just one photolithographic step. These were further modified by covalent immobilization of HRP using silanization chemistry. Simulation studies of the proposed approach showed a sensor linear behavior up to 300 microM H2O2 and a sensitivity of 2.7 x 10(-3) AU/microM. Experimental results were in good agreement with the simulated ones. A linear behavior between 10 and 300 microM H2O2, a sensitivity of 3 x 10(-3) AU/microM, and a signal-to-noise ratio around 20 dB were attained. Also, kinetic studies of the activity of the immobilized enzyme on the silicon waveguide surface gave an apparent Michaelis-Menten constant of 0.44 mM. The simple technology proposed in this work enables the fabrication of cost-effective, easy-to-use, miniaturized biosensor generic platforms, these being envisioned as excellent candidates for the development of lab-on-a-chip systems.

Topics: Benzothiazoles; Biosensing Techniques; Enzymes, Immobilized; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Microfluidic Analytical Techniques; Optics and Photonics; Silicon; Sulfonic Acids

2008