silicon and 1-(chloromethyl)silatrane

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

Topics: 2,3-Diketogulonic Acid; Alloxan; Animals; Anti-Ulcer Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Combinations; Ferric Compounds; Lipid Peroxidation; Organosilicon Compounds; Rats; Silicon; Stomach Ulcer; Uracil

Topics: Adenosine Triphosphatases; Cell Membrane; Cell Membrane Permeability; In Vitro Techniques; Lipid Bilayers; Lipid Peroxides; Membrane Fluidity; Membrane Lipids; Models, Biological; Organosilicon Compounds; Silicon

The damaging effect of cardiopulmonary bypass on blood elements and the possibility of its correction with 1-(chloromethyl) silatrane have been investigated. Cardiopulmonary bypass is a powerful damaging factor producing a wide range of effects including the activation of lipid peroxidation, reduction of erythrocyte membrane resistance to ultra-sound, destruction of blood elements and appearance of hemoglobin in the plasma (hemolysis). A possible mechanism of cardiopulmonary bypass damaging effect on blood elements is suggested. The use of 1-(chloromethyl)silatrane drastically increases the resistance of blood element membranes to injury, which seems promising for the drug application during cardiopulmonary bypass.

Topics: Animals; Dogs; Erythrocyte Membrane; Erythrocytes; Extracorporeal Circulation; Hemoglobins; Kinetics; Lipid Peroxides; Organosilicon Compounds; Oxidation-Reduction; Silicon; Time Factors

Topics: Adrenal Glands; Animals; Corticosterone; Epinephrine; Glycogen; Liver Glycogen; Male; Myocardium; Organosilicon Compounds; Rats; Silicon; Stomach Ulcer; Stress, Psychological

It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.

Topics: 2,3-Diketogulonic Acid; Alloxan; Animals; Anti-Ulcer Agents; Drug Combinations; Ferric Compounds; Hexosamines; Hexoses; Hexuronic Acids; Hydroxyproline; Methylthiouracil; Organosilicon Compounds; Rats; Sialic Acids; Silicon; Stomach Ulcer; Tyrosine

Histochemical methods have disclosed that external application of 5% ointment of 1-(chlormethyl)silatran leads to an increase of the glycogen and RNA content in guinea-pig skin, reduction of the heparin content in the basal membrane and external epithelial vagina. Factors that give rise to pilotropic activity of 1-(chlormethyl)silatran are discussed.

Topics: Animals; Glycogen; Glycosaminoglycans; Guinea Pigs; Hair Preparations; Heparin; Ointments; Organosilicon Compounds; RNA; Silicon; Skin

Experiments on rats were made to study the effect of I-(chloromethyl) silatrane and I- (ethoxy) silatrane and that of triethanolamine and chloromethyl triethoxysilane on biochemical parameters of granular-fibrous tissue. The preparations were applied to a wound defect in the form of liniments. Silatranes were found to stimulate proliferation of the cells and to increase their biosynthetic activity, to favour accumulation of collagen and non-collagenic proteins, and reduction of the inflammatory phenomena. The silicon-containing fragment of the silatrane molecule chloromethyl triethoxysilane produced an analogous but less marked action. Triethanolamine containing no silicon was found to be as less active. These data indicate that silicon entering the silatrane grouping is of great importance for the occurrence of its biological activity.

Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Ethanolamines; Granulation Tissue; Liniments; Organosilicon Compounds; Rats; Silicon; Stimulation, Chemical

Topics: Animals; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Fertility; Male; Mutagens; Organosilicon Compounds; Silicon