sildenafil has been researched along with zaprinast* in 1 studies
1 other study(ies) available for sildenafil and zaprinast
| Article | Year |
|---|---|
N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.
Phosphodiesterase type 5 (PDE5) inhibitors with improved PDE isozyme selectivity relative to sildenafil may result in agents for the treatment of male erectile dysfunction (MED) with a lower incidence of PDE-associated adverse effects. This paper describes the discovery of 14, a PDE5 inhibitor with improved potency and selectivity in vitro compared to sildenafil. This compound shows activity in a functional assay of erectile function comparable to that of sildenafil. Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Erectile Dysfunction; Imidazoles; In Vitro Techniques; Male; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Purinones; Quinazolines; Rabbits; Sildenafil Citrate; Structure-Activity Relationship; Sulfones | 2000 |