silatrane and 1-(chloromethyl)silatrane

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

Topics: 2,3-Diketogulonic Acid; Alloxan; Animals; Anti-Ulcer Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Combinations; Ferric Compounds; Lipid Peroxidation; Organosilicon Compounds; Rats; Silicon; Stomach Ulcer; Uracil

Experiments on rats were made to study the effect of I-(chloromethyl) silatrane and I- (ethoxy) silatrane and that of triethanolamine and chloromethyl triethoxysilane on biochemical parameters of granular-fibrous tissue. The preparations were applied to a wound defect in the form of liniments. Silatranes were found to stimulate proliferation of the cells and to increase their biosynthetic activity, to favour accumulation of collagen and non-collagenic proteins, and reduction of the inflammatory phenomena. The silicon-containing fragment of the silatrane molecule chloromethyl triethoxysilane produced an analogous but less marked action. Triethanolamine containing no silicon was found to be as less active. These data indicate that silicon entering the silatrane grouping is of great importance for the occurrence of its biological activity.

Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Ethanolamines; Granulation Tissue; Liniments; Organosilicon Compounds; Rats; Silicon; Stimulation, Chemical