silaproline and thiazolidine-4-carboxylic-acid

silaproline has been researched along with thiazolidine-4-carboxylic-acid* in 1 studies

Other Studies

1 other study(ies) available for silaproline and thiazolidine-4-carboxylic-acid

Article	Year
Conformational studies of proline-, thiaproline- and dimethylsilaproline-containing diketopiperazines. Journal of peptide science : an official publication of the European Peptide Society, 2006, Volume: 12, Issue:10 As proline plays an important role in biologically active peptides, many analogues of this residue have been developed to modulate the proportion of cis and trans conformers. A correlation between the pyrrolidine ring shape and structural properties of proline has been established. Diketopiperazine (DKP) is the model of choice to study the influence of the proline ring modification. In this contribution, cyclo(Gly-Pro) and two analogues cyclo(Sip-Pro) and cyclo(Thz-Pro) have been studied with proton NMR. We showed that both analogues with heteroatoms in gamma position, silicon and sulfur respectively, display a more rigid five-member ring. The usual flexibility of proline ring is restrained in both cases and only the two C(beta)-exo and C(beta)-endo conformations are observed. Topics: Diketopiperazines; Magnetic Resonance Spectroscopy; Molecular Conformation; Organosilicon Compounds; Piperazines; Proline; Protein Conformation; Thiazolidines	2006

Article

Year

Conformational studies of proline-, thiaproline- and dimethylsilaproline-containing diketopiperazines.

Journal of peptide science : an official publication of the European Peptide Society, 2006, Volume: 12, Issue:10

As proline plays an important role in biologically active peptides, many analogues of this residue have been developed to modulate the proportion of cis and trans conformers. A correlation between the pyrrolidine ring shape and structural properties of proline has been established. Diketopiperazine (DKP) is the model of choice to study the influence of the proline ring modification. In this contribution, cyclo(Gly-Pro) and two analogues cyclo(Sip-Pro) and cyclo(Thz-Pro) have been studied with proton NMR. We showed that both analogues with heteroatoms in gamma position, silicon and sulfur respectively, display a more rigid five-member ring. The usual flexibility of proline ring is restrained in both cases and only the two C(beta)-exo and C(beta)-endo conformations are observed.

Topics: Diketopiperazines; Magnetic Resonance Spectroscopy; Molecular Conformation; Organosilicon Compounds; Piperazines; Proline; Protein Conformation; Thiazolidines

2006