sidnocarb and phenazepam

The correcting action of sydnocarb on the side effects of phenazepam was studied in experimental and clinical conditions. The effect of sydnocarb on the myorelaxant, hypnotic, and tranquilizing effects of phenazepam was determined on 144 mice and 87 rats. Comparative clinical trials of phenazepam with regard to the same effects were carried out on 102 patients with anxious-depressive states. The patients received phenazepam both in combination with sydnocarb and alone. The experiments and the clinical trials have shown that sydnocarb reduces the myorelaxant and hypnotic effects of phenazepam without influencing its tranquilizing action. The phenazepam: sydnocarb ratio optimal for correcting the side effects of the tranquilizer was found to range with 1: 1.25 to 1:2.5.

Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Consciousness Disorders; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Muscle Hypotonia; Oxadiazoles; Rats; Sleep Stages; Sydnones

In a placebo-controlled study, changes in psychophysiological status of operators (38 healthy male volunteers aged 23-35 years) performing 4-hour model operator activity were evaluated after a single oral administration of typical representatives of the different classes of drugs (haloperidol, proroxan, yohimbine hydrochloride, propranolol, mesocarb, isoprenaline, Belladonna extract, anabasine hydrochloride, valproate sodium, and phenazepam), which are used for the treatment, rehabilitation and prophylaxis of common diseases. It was found that all the drugs modified to a greater or lesser extent some components of the model operator activity. Isoprenaline and phenazepam had the most negative effect on the psychophysiological indicators and quality of the modeled operator activity. The results should be considered before administration of such drugs to working operators.

Topics: Adult; Anabasine; Attention; Belladonna Alkaloids; Benzodiazepines; Central Nervous System Stimulants; Dioxanes; Double-Blind Method; Haloperidol; Humans; Isoproterenol; Male; Propranolol; Psychophysiology; Sydnones; Task Performance and Analysis; Tranquilizing Agents; Valproic Acid; Yohimbine

In REM-sleep-deprived rats, phenazepam (1.0 mg/kg) prevented the SH-group content increase in the brain stem membrane proteins, but induced undesirable sedative phenomena which, however, could be eliminated by simultaneous injections of sydnocarbum. The data obtained suggest that if the brain stem membrane proteins are protected against a denaturation-like alteration (characterized by the increase of SH-group content of these proteins) during REM-sleep deprivation, there is no "rebound" of this sleep phase after the end if the experiment in the condition of the unrestrained behavior of the rats.

Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain Stem; Chemical Phenomena; Chemistry; Drug Interactions; Electroencephalography; Membrane Proteins; Nerve Tissue Proteins; Oxadiazoles; Rats; Rats, Inbred Strains; Sleep Deprivation; Sleep, REM; Sydnones

The effect of phenazepam and sydnocarb in doses of 0.05, 0.07 and 0.1 mg/kg or 6, 12 and 24 mg/kg, respectively, on the behaviour of C57BL/6, CBA and BALB/c mice, was studied in the "open field" test. Interlinear difference in the reaction of inbred animals to emotional stress and its phenazepam or sydnocarb correction were established.

Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Oxadiazoles; Psychotropic Drugs; Species Specificity; Stress, Psychological; Sydnones