Compounds > sibutramine
Page last updated: 2024-08-16

sibutramine and clopidogrel

sibutramine has been researched along with clopidogrel in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bae, SK; Cao, S; Kim, H; Kim, MJ; Liu, KH; Seo, KA; Shin, JG; Shon, JH; Zhou, HH1
Bae, JW; Jang, CG; Lee, SY1
Bae, SK; Lee, SS; Pan, W; Park, SE; Park, SJ; Shim, EJ; Shin, JG; Shon, JH; Yeo, CW; Zhou, HH1
Bae, SK; Choi, JS; Kim, DH; Kim, HS; Pan, W; Shin, JG; Shinde, DD; Shon, JH; Yeo, CW1
Balupuri, A; Chea, S; Chin, YW; Choi, YH; Gong, EC; Kang, NS1

Reviews

1 review(s) available for sibutramine and clopidogrel

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for sibutramine and clopidogrel

ArticleYear
Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:12

    Topics: Adult; Appetite Depressants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genotype; Half-Life; Heart Rate; Humans; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Young Adult

2011
Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:5

    Topics: Adult; Appetite Depressants; Aryl Hydrocarbon Hydroxylases; Clarithromycin; Clopidogrel; Cross-Over Studies; Cyclobutanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Genotype; Humans; Male; Microsomes; Oxidoreductases, N-Demethylating; Polymorphism, Genetic; Stereoisomerism; Ticlopidine; Young Adult

2013

Other Studies

4 other study(ies) available for sibutramine and clopidogrel

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:8

    Topics: Appetite Depressants; Aryl Hydrocarbon Hydroxylases; Catalysis; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; DNA, Complementary; Humans; Microsomes, Liver; Oxidoreductases, N-Demethylating; Ticlopidine

2008
Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism.
    Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:2

    Topics: Anti-Bacterial Agents; Appetite Depressants; Aryl Hydrocarbon Hydroxylases; Asian People; Clarithromycin; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; Humans; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Republic of Korea; Ticlopidine

2013
Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone.
    Molecules (Basel, Switzerland), 2018, Mar-02, Volume: 23, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Benzopyrans; Binding Sites; Catalytic Domain; Chlorzoxazone; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Herb-Drug Interactions; Humans; Hypoglycemic Agents; Kinetics; Mice; Microsomes, Liver; Molecular Docking Simulation; Plant Components, Aerial; Plant Extracts; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Saururaceae; Ticlopidine

2018