sibenadet has been researched along with thiazoles in 22 studies
| Studies (sibenadet) | Trials (sibenadet) | Recent Studies (post-2010) (sibenadet) | Studies (thiazoles) | Trials (thiazoles) | Recent Studies (post-2010) (thiazoles) |
|---|---|---|---|---|---|
| 27 | 7 | 6 | 33,179 | 2,100 | 12,330 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 18 (81.82) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonnert, RV; Brown, RC; Chapman, D; Cheshire, DR; Davis, AM; Dixon, J; Dougall, IG; Hallam, C; Harper, ST; Ince, F; Jackson, DM; Kinchin, EC; Lyons, AJ; McKechnie, K; Simpson, WT; Unitt, JF; Young, A | 1 |
| Lockley, WJ; Mather, A; Preston, JR; Singh, J; Wilkinson, D; Willson, VJ | 1 |
| Bayliss, MA; Gilbert, CM; Lockley, WJ; Mather, A; Singh, J; Wilkinson, D; Willson, VJ | 1 |
| Baur, F; Collingwood, SP; Fozard, JR; Wolber, C | 1 |
| Jackson, D; Jones, B; Lindsey, JK; Stevens, JW | 1 |
| Rennard, SI | 1 |
| Dougall, IG; Ince, F; Jackson, DM; Young, A | 1 |
| Deamer, L; Ind, PW; Laitinen, L; Laursen, L; Nystrom, P; Wenzel, S; Wouters, E | 1 |
| Hepburn, T; Laursen, LC; Lindqvist, A; Lloyd, J; Perrett, J; Rocchiccioli, K; Sanders, N | 1 |
| Byrne, N; Celli, B; Goldman, M; Halpin, D; Hepburn, R; Keating, ET | 1 |
| Alderfer, V; Goldman, M; Hiller, FC | 1 |
| Jones, MK; Lordan, N; McMillan, C; O'Brien, JA; Ward, AJ | 1 |
| Jones, MK; Leidy, NK; Lloyd, J; Rocchiccioli, K; Schmier, JK | 1 |
| Calverley, P; Casty, F; Goldman, M; Keating, ET | 1 |
| Källén, A | 1 |
| Buescher, H; Farr, DC; Fozard, JR; Mazzoni, L | 1 |
| Agnew, JE; Dilworth, JP; Hasani, A; Lloyd, J; Toms, N | 1 |
| Austin, TK; Cosgrove, SD; Ferrari, E; Plumb, AP; Roberts, KJ; Steele, G; Stensland, B | 1 |
| Newbold, P; Reele, SB; Sanders, N | 1 |
| Alcaraz, L; Bailey, A; Cadogan, E; Christie, J; Connolly, S; Cook, AR; Fisher, AJ; Hill, S; Humphries, A; Ingall, AH; Kane, Z; Paine, S; Pairaudeau, G; Stocks, MJ; Young, A | 1 |
| Alcaraz, L; Bailey, A; Cadogan, E; Connolly, S; Dainty, I; Jewell, R; Jordan, S; Kindon, N; Lawson, M; Lister, A; Mullen, A; Nicholls, D; Paine, S; Pairaudeau, G; Stocks, MJ; Thorne, P; Young, A | 1 |
| Bradley, JP; Brown, SP; Burley, JC; Cosgrove, SD; Hughes, LP; Martin, DR; Pickard, CJ | 1 |
7 trial(s) available for sibenadet and thiazoles
| Article | Year |
|---|---|
Early clinical investigation of Viozan (sibenadet HCl), a novel D2 dopamine receptor, beta2-adrenoceptor agonist for the treatment of chronic obstructive pulmonary disease symptoms.
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Aged; Bronchodilator Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Metered Dose Inhalers; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Thiazoles; Treatment Outcome; Vital Capacity | 2003 |
The role of the novel D2/beta2-agonist, Viozan (sibenadet HCl), in the treatment of symptoms of chronic obstructive pulmonary disease: results of a large-scale clinical investigation.
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Metered Dose Inhalers; Middle Aged; Patient Satisfaction; Peak Expiratory Flow Rate; Pulmonary Disease, Chronic Obstructive; Quality of Life; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Thiazoles; Treatment Outcome | 2003 |
Symptoms are an important outcome in chronic obstructive pulmonary disease clinical trials: results of a 3-month comparative study using the Breathlessness, Cough and Sputum Scale (BCSS).
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Bronchodilator Agents; Cough; Double-Blind Method; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Metered Dose Inhalers; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Sputum; Survival Analysis; Thiazoles; Treatment Outcome; Vital Capacity | 2003 |
Long-term use of Viozan (sibenadet HCl) in patients with chronic obstructive pulmonary disease: results of a 1-year study.
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Long-Term Care; Male; Metered Dose Inhalers; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Smoking; Thiazoles; Treatment Outcome | 2003 |
Utilization of health care services by patients with chronic obstructive pulmonary disease.
Topics: Adrenergic beta-2 Receptor Agonists; Adult; Aged; Bronchodilator Agents; Double-Blind Method; Female; Health Services; Hospitalization; Humans; Male; Middle Aged; Patient Acceptance of Health Care; Pulmonary Disease, Chronic Obstructive; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Thiazoles | 2003 |
Evaluating symptoms in chronic obstructive pulmonary disease: validation of the Breathlessness, Cough and Sputum Scale.
Topics: Adrenergic beta-Antagonists; Aged; Bronchodilator Agents; Cough; Data Collection; Dopamine Antagonists; Dyspnea; Female; Health Status Indicators; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Reproducibility of Results; Sensitivity and Specificity; Sputum; Thiazoles | 2003 |
Mucociliary clearance in COPD can be increased by both a D2/beta2 and a standard beta2 agonists.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Aged; Albuterol; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Mucociliary Clearance; Peak Expiratory Flow Rate; Pulmonary Disease, Chronic Obstructive; Quality of Life; Risk Factors; Smoking; Sputum; Thiazoles; Treatment Outcome; Vital Capacity | 2005 |
15 other study(ies) available for sibenadet and thiazoles
| Article | Year |
|---|---|
Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Anti-Asthmatic Agents; Bronchoconstriction; Dogs; Dopamine Agonists; Drug Evaluation, Preclinical; Ear; In Vitro Techniques; Lung Diseases, Obstructive; Mucus; Rabbits; Receptors, Dopamine D2; Respiration; Thiazoles; Vasoconstriction | 1998 |
A RIA combined with SPE for the determination of a dual D2-receptor and beta2-adrenoceptor agonist, AR-C68397XX, in human plasma.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Antibody Specificity; Cross Reactions; Dopamine Agonists; Humans; Iodine Radioisotopes; Isotope Labeling; Pharmaceutical Solutions; Radioimmunoassay; Receptors, Dopamine D2; Reproducibility of Results; Serum Albumin, Bovine; Sheep; Thiazoles | 2000 |
A time-resolved fluorescence immunoassay for the determination of a novel respiratory therapeutic agent, AR-C68397XX (Viozan) in human plasma.
Topics: Adrenergic beta-Agonists; Humans; Immunoassay; Lung Diseases, Obstructive; Reproducibility of Results; Thiazoles | 2000 |
Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by beta 2-adrenoceptors.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Animals; Blood Proteins; Capsaicin; Dose-Response Relationship, Drug; Extravasation of Diagnostic and Therapeutic Materials; Injections, Intraperitoneal; Intubation, Intratracheal; Male; Propranolol; Rats; Rats, Inbred BN; Receptors, Adrenergic, beta-2; Sulpiride; Thiazoles; Trachea | 2001 |
Dynamic modelling of a challenge-escalation cross-over study of treatment of capsaicin-induced coughing.
Topics: Adrenergic beta-Agonists; Albuterol; Capsaicin; Cough; Cross-Over Studies; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Humans; Longitudinal Studies; Male; Models, Statistical; Receptors, Dopamine D2; Thiazoles | 2002 |
Introduction. The symposium that never occurred: pre-clinical and clinical development of sibenadet.
Topics: Adrenergic beta-Agonists; Bronchodilator Agents; Dopamine Antagonists; Humans; Pulmonary Disease, Chronic Obstructive; Thiazoles; Treatment Outcome | 2003 |
Dual dopamine D2 receptor and beta2-adrenoceptor agonists for the treatment of chronic obstructive pulmonary disease: the pre-clinical rationale.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Drug Design; Humans; Models, Biological; Neurons, Afferent; Pulmonary Disease, Chronic Obstructive; Receptors, Dopamine D2; Thiazoles | 2003 |
Conclusion. Lessons from the novel D2 dopamine receptor, beta2-adrenoceptor agonist, Viozan: chronic obstructive pulmonary disease and drug development implications.
Topics: Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Cough; Drug Design; Dyspnea; Forced Expiratory Volume; Humans; Pulmonary Disease, Chronic Obstructive; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Research Design; Sputum; Thiazoles | 2003 |
Multivariate estimation of the relative dose potency.
Topics: Administration, Inhalation; Anti-Asthmatic Agents; Asthma; Blood Glucose; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Evaluation; Electrocardiography; Heart Rate; Humans; Multivariate Analysis; Potassium; Randomized Controlled Trials as Topic; Respiratory Function Tests; Thiazoles | 2004 |
Suppression of histamine-induced tachypnoea in the rhesus monkey by sibenadet: no role for dopamine D2 receptors.
Topics: Adrenergic beta-Agonists; Aerosols; Airway Resistance; Animals; Anti-Asthmatic Agents; Bronchoconstrictor Agents; Dopamine Agonists; Ethanolamines; Formoterol Fumarate; Heart Rate; Hemodynamics; Histamine; Histamine Antagonists; Macaca mulatta; Male; Methacholine Chloride; Receptors, Dopamine D2; Respiratory Function Tests; Respiratory Mechanics; Thiazoles | 2004 |
Understanding the polymorphic behavior of sibenadet hydrochloride through detailed studies integrating structural and dynamical assessment.
Topics: Adrenergic beta-2 Receptor Agonists; Calorimetry, Differential Scanning; Crystallization; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning; Powders; Receptors, Dopamine D2; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Surface Properties; Temperature; Thiazoles; X-Ray Diffraction | 2005 |
Lack of correlation between exercise and sibenadet-induced changes in heart rate corrected measurement of the QT interval.
Topics: Adult; Dose-Response Relationship, Drug; Exercise; Female; Heart Rate; Humans; Male; Middle Aged; Thiazoles | 2007 |
Design-driven LO: the discovery of new ultra long acting dibasic β2-adrenoceptor agonists.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Bronchodilator Agents; Drug Design; Drug Evaluation, Preclinical; Guinea Pigs; Receptors, Adrenergic, beta-2; Structure-Activity Relationship; Thiazoles | 2011 |
From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchodilator Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Cyclic AMP; Drug Design; Guinea Pigs; Humans; Inhibitory Concentration 50; Models, Chemical; Protein Binding; Pulmonary Disease, Chronic Obstructive; Thiazoles; Time Factors | 2012 |
Probing intermolecular hydrogen bonding in sibenadet hydrochloride polymorphs by high-resolution (1) H double-quantum solid-state NMR spectroscopy.
Topics: Adrenergic beta-Agonists; Crystallography, X-Ray; Dopamine Agonists; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Protons; Quantum Theory; Thiazoles | 2012 |