shogaol has been researched along with allyl-alcohol* in 1 studies
1 other study(ies) available for shogaol and allyl-alcohol
| Article | Year |
|---|---|
Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: formation of allyl alcohol metabolites from shogaol and dehydroparadol.
A novel reductive metabolism of shogaol [1-(4'-hydroxy-3'-methoxyphenyl)-deca-4-ene-3-one], a major pungent and pharmacologically active principle of ginger, was investigated in rat liver in vitro. The ethyl acetate extractable metabolites formed by incubation of this alpha,beta-unsaturated ketone with rat liver 12,000 x g supernatant fortified with NADPH-generating system were analyzed by high performance chromatography and gas chromatography/mass spectrometry. In addition to the saturated ketone and reduced alcohol metabolites, an allyl alcohol, 1-(4'-hydroxy-3'-methoxyphenyl)-deca-4-ene-3-ol, was identified as a new metabolite of shogaol. Likewise, dehydroparadol [1-(4'-hydroxy-3'-methoxyphenyl)-deca-1-ene-3-one], a non-pungent analog of shogaol, was also reduced to the corresponding allyl alcohol by the postmitochondrial fraction of rat kidney in the presence of NADPH-generating system. Topics: 1-Propanol; Allyl Compounds; Animals; Catechols; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Guaiacol; Kidney; Liver; Male; Mutagens; Oxidation-Reduction; Plant Extracts; Propanols; Rats; Rats, Sprague-Dawley | 1994 |