shikonin and esculetin

shikonin has been researched along with esculetin* in 1 studies

Other Studies

1 other study(ies) available for shikonin and esculetin

Article	Year
Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method. The Journal of toxicological sciences, 2018, Volume: 43, Issue:8 We evaluated the skin sensitizing potential of 10 natural organic chemicals, or their derivatives, which are included in foods and/or skin products, using a modified local lymph node assay (LLNA), with an elicitation phase (LLNA:DAE). The following compounds were tested: carminic acid, esculetin, 4-methyl esculetin, coumarin, quercetin, curcumin, naringenin, chlorogenic acid, isoscopoletin, and shikonin. Esculetin, 4-methyl esculetin, isoscopoletin, and shikonin yielded positive results. In particular, shikonin at a very low concentration (0.05%) induced an elicitation response. In conclusion, four of the 10 natural organic chemicals tested had a skin sensitization potential, with shikonin producing serious reaction even at a very low concentration. Topics: Animals; Carmine; Cosmetics; Coumarins; Curcumin; Dose-Response Relationship, Drug; Female; Food Analysis; Local Lymph Node Assay; Mice, Inbred CBA; Naphthoquinones; Quercetin; Skin; Skin Irritancy Tests; Umbelliferones	2018

Article

Year

Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method.

The Journal of toxicological sciences, 2018, Volume: 43, Issue:8

We evaluated the skin sensitizing potential of 10 natural organic chemicals, or their derivatives, which are included in foods and/or skin products, using a modified local lymph node assay (LLNA), with an elicitation phase (LLNA:DAE). The following compounds were tested: carminic acid, esculetin, 4-methyl esculetin, coumarin, quercetin, curcumin, naringenin, chlorogenic acid, isoscopoletin, and shikonin. Esculetin, 4-methyl esculetin, isoscopoletin, and shikonin yielded positive results. In particular, shikonin at a very low concentration (0.05%) induced an elicitation response. In conclusion, four of the 10 natural organic chemicals tested had a skin sensitization potential, with shikonin producing serious reaction even at a very low concentration.

Topics: Animals; Carmine; Cosmetics; Coumarins; Curcumin; Dose-Response Relationship, Drug; Female; Food Analysis; Local Lymph Node Assay; Mice, Inbred CBA; Naphthoquinones; Quercetin; Skin; Skin Irritancy Tests; Umbelliferones

2018