shikonin has been researched along with coumarin* in 2 studies
2 other study(ies) available for shikonin and coumarin
| Article | Year |
|---|---|
The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis.
In current study, a series of shikonin derivatives were synthesized and its anticancer activity was evaluated. As a result, PMMB232 showed the best antiproliferation activity with an IC Topics: Antineoplastic Agents; Apoptosis; Carboxylic Acids; Coumarins; Drug Evaluation, Preclinical; Female; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Docking Simulation; Naphthoquinones; Uterine Cervical Neoplasms | 2018 |
Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method.
We evaluated the skin sensitizing potential of 10 natural organic chemicals, or their derivatives, which are included in foods and/or skin products, using a modified local lymph node assay (LLNA), with an elicitation phase (LLNA:DAE). The following compounds were tested: carminic acid, esculetin, 4-methyl esculetin, coumarin, quercetin, curcumin, naringenin, chlorogenic acid, isoscopoletin, and shikonin. Esculetin, 4-methyl esculetin, isoscopoletin, and shikonin yielded positive results. In particular, shikonin at a very low concentration (0.05%) induced an elicitation response. In conclusion, four of the 10 natural organic chemicals tested had a skin sensitization potential, with shikonin producing serious reaction even at a very low concentration. Topics: Animals; Carmine; Cosmetics; Coumarins; Curcumin; Dose-Response Relationship, Drug; Female; Food Analysis; Local Lymph Node Assay; Mice, Inbred CBA; Naphthoquinones; Quercetin; Skin; Skin Irritancy Tests; Umbelliferones | 2018 |