sf-837 has been researched along with cladinose* in 1 studies
1 other study(ies) available for sf-837 and cladinose
| Article | Year |
|---|---|
Cladinose analogues of sixteen-membered macrolide antibiotics. I. Synthesis of 4-O-alkyl-L-cladinose analogues via glycosylation.
The synthesis and biological evaluation of sixteen-membered macrolides possessing a 4-O-alkyl-alpha-L-cladinosyl moiety as the neutral sugar are described. The nine novel derivatives have been synthesized by glycosylation with 1-thio sugars. The most active derivative of them showed prolonged antibacterial activity in rat plasma in vitro and improved pharmacokinetics. Topics: Animals; Anti-Bacterial Agents; Glycosylation; Hexoses; Leucomycins; Male; Mice; Microbial Sensitivity Tests; Rats; Structure-Activity Relationship | 1996 |