sew2871 has been researched along with plerixafor* in 1 studies
1 other study(ies) available for sew2871 and plerixafor
| Article | Year |
|---|---|
CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model.
Both immunosuppressive and cytoreductive effects of γ-irradiation contribute to engraftment of allogeneic haematopoietic stem and progenitor cells. We hypothesized that a release of host stem and progenitor cells from the niche prior to conditioning would permit engraftment after less intensive conditioning. Administration of AMD3100 and SEW2871 on days -4 to -2 followed by irradiation on day -1 in a non-myeloablative zebrafish transplant model resulted in a reduced radiation minimum dose of 10 Gy from 15 Gy being sufficient for engraftment. Targeting the SDF-1 (CXCL12)/CXCR4- and S1P/S1P1 -axis increased the efficacy of allografting in an experimental transplant model. Topics: Animal Experimentation; Animals; Benzylamines; Cyclams; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Heterocyclic Compounds; Lysophospholipids; Oxadiazoles; Receptors, CXCR4; Signal Transduction; Sphingosine; Thiophenes; Transplantation Chimera; Transplantation, Homologous; Zebrafish | 2014 |