sespendole and anthranilic-acid

Sespendole is the first reported fungal metabolite having an indolosesquiterpene core structure. The biosynthesis of sespendole was studied here by feeding experiments with [13C]acetate, [15N]anthranilic acid and [13C]tryptophan. The data suggested that a farnesyl residue derived from the mevalonate pathway and an anthranilate-derived indole-3-glycerol phosphate residue are condensed, and then cyclization occurs along with rearrangement to form the indolosesquiterpene core.

Topics: Acetates; Diterpenes; Fungi; Indoles; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Tryptophan