sesamodil has been researched along with thiazoles in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 44 (88.00) | 18.2507 |
| 2000's | 6 (12.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morimoto, K; Nakayama, K; Nozawa, Y; Tanaka, Y | 1 |
| Haruno, A; Hashimoto, K; Hirasawa, A; Matsuzaki, T | 1 |
| Araki, S; Fukuchi, M; Hashimoto, H; Matsuzaki, T; Nagashima, S; Nakashima, M; Uematsu, T | 1 |
| Abe, Y; Aki, Y; He, H; Iwao, H; Kiyomoto, H; Masumura, H; Nishiyama, A; Tamaki, T; Yamamoto, A | 1 |
| Kageyama, M; Satoh, K; Taira, N; Yamada, H | 1 |
| Furuta, T; Iso, T; Miyawaki, N; Shigei, T; Yamauchi, H | 2 |
| Kageyama, M; Miyawaki, N; Nishimura, K; Takada, T; Yamauchi, H | 1 |
| Ishida, N; Iso, T; Kageyama, M; Matsuno, K; Miyawaki, N; Takada, T; Yamauchi, H | 1 |
| Furuta, T; Miyawaki, N; Shigei, T; Yamauchi, H; Yamazaki, F | 1 |
| Fujita, M; Ibuki, H; Ito, S; Kawashima, Y; Suhara, H | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Iso, T; Miyawaki, N; Nishimura, K; Yamauchi, H | 1 |
| Horiuchi, M; Morishima, K; Tahara, R | 1 |
| Fukuchi, M; Nagashima, S; Nakashima, M; Uematsu, T | 1 |
| Fukuta, Y; Nakayama, K; Nozawa, Y | 1 |
| Fujino, T; Ishida, S; Ito, M; Maruyama, T; Saikawa, T; Takahashi, N | 1 |
| Kageyama, M; Taira, N; Yanagisawa, T | 1 |
| Akashi, S; Ichikawa, M; Koida, M; Machidera, Y; Manno, K; Nakamuta, H; Ohtsuji, T; Wanaka, M | 1 |
| Ito, K; Ito, KM; Murakami, K; Shindo, K | 1 |
| Kodama, I; Maruyama, K; Suzuki, R; Toyama, J | 1 |
| Fujimura, K; Fujita, M; Kawashima, Y; Suhara, H | 1 |
| Araki, S; Hashimoto, H; Ishii, M; Nagashima, S; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Ishii, K; Ishii, S; Ishiwata, K; Nozaki, T; Seki, H; Senda, M | 1 |
| Hashimoto, H; Kanda, A | 1 |
| Teramoto, N | 1 |
| Chiba, K; Fukuzawa, A; Ishigai, Y; Mori, T; Shibano, T | 1 |
| Decrinis, M; Kasper, K; Miyawaki, N; Stark, G; Stark, U; Tritthart, HA | 1 |
| Hara, Y; Nakaya, H | 1 |
| Iida, M; Kodama, I; Toyama, J | 1 |
| Imai, S; Kanda, T; Kobayashi, I; Murata, K; Suzuki, T; Takahashi, T | 2 |
| Hakusui, H; Katoh, K; Nakaoka, M | 1 |
| Fujimura, K; Kawashima, Y; Ota, A | 1 |
| Koidl, B; Miyawaki, N; Tritthart, HA | 1 |
| Fujiki, A; Hayashi, H; Inoue, H; Mizumaki, K; Nakaya, H; Tani, M; Uemura, H | 1 |
| Nakagawa, T; Rodriguez, ME; Shibukawa, A; Ueda, K; Yamaoka, K | 1 |
| Nakagawa, T; Rodriguez Rosas, ME; Shibukawa, A; Ueda, K | 1 |
| Nakagawa, M; Sasaki, S | 1 |
| Iino, M; Itagaki, K; Kraft, G; Kuniyasu, A; Nakayama, H; Schwartz, A; Shibano, T | 1 |
| Ii, N; Kawahara, K; Kuniyasu, A; Nakayama, H; Schwartz, A; Shibano, T | 1 |
| Kuroda, Y; Nakagawa, T; Rodriguez Rosas, ME; Shibukawa, A; Yoshikawa, Y | 1 |
| Aghajanian, AA; Kritz, H; Oguogho, A; Sinzinger, H | 1 |
| Nakajima, M; Shimada, N; Suzuki, M; Takashina, H; Yamaji, R; Yamazaki, H; Yokoi, T | 1 |
| Brodmann, M; Haiden, U; Schwarzl, I; Stark, G; Stark, U; Tritthart, HA | 1 |
| Kajimura, T; Nomura, M; Ohno, H; Satoh, H; Sugawara, T; Tsuchiya, Y | 1 |
| Araie, M; Fukaya, Y; Matsubara, M; Tamaki, Y; Tomidokoro, A; Tomita, K | 1 |
| Ishiguro, M; Kawahara, K; Kuniyasu, A; Masuda, K; Nakayama, H | 1 |
| Kritz, H; Oguogho, A; Sinzinger, H; Wolfram, RM | 1 |
| Adamson, PB; Foreman, RD; Schwartz, PJ; Shibano, T; Vanoli, E | 1 |
1 review(s) available for sesamodil and thiazoles
| Article | Year |
|---|---|
[Calcium channel blocker for therapy of patients with hypertension].
Topics: Benzimidazoles; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Humans; Hypertension; Mibefradil; Nifedipine; Tetrahydronaphthalenes; Thiazoles | 1997 |
49 other study(ies) available for sesamodil and thiazoles
| Article | Year |
|---|---|
Calcium antagonistic and binding properties of semotiadil (SD-3211), a benzothiazine derivative assessed in cerebral and coronary arteries.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Arteries; Coronary Vessels; Cytosol; Dogs; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Radioligand Assay; Stereoisomerism; Swine; Thiazoles | 1992 |
Effects of a new antiarrhythmic drug, SD-3212, on canine ventricular arrhythmia models.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Digitalis; Dogs; Epinephrine; Female; Ligation; Male; Osmolar Concentration; Plants, Medicinal; Plants, Toxic; Thiazoles | 1992 |
Antiarrhythmic and electrophysiological effects of SD-3212, a novel Na+ and Ca++ channel blocker, in anaesthetized dogs with myocardial infarction in comparison with its stereoisomer (SD-3211) and bepridil.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Dogs; Electrophysiology; Female; Heart; Heart Conduction System; Male; Myocardial Infarction; Sodium Channels; Stereoisomerism; Thiazoles | 1992 |
Effects of semotiadil fumarate (SD-3211) on renal hemodynamics and function in dogs.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Calcium Channel Blockers; Diuresis; Dogs; Electrolytes; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Renal Circulation; Renin-Angiotensin System; Tetrazoles; Thiazoles | 1992 |
Effects of semotiadil (SD-3211), a benzothiazine calcium antagonist, on blood pressure and atrioventricular conductivity in anesthetized dogs.
Topics: Anesthesia; Animals; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Male; Neural Conduction; Stellate Ganglion; Thiazoles; Vagotomy; Vagus Nerve | 1992 |
Electrophysiological properties of SD-3211, a novel putative Ca2+ antagonist, in isolated guinea pig and rabbit hearts.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Male; Perfusion; Rabbits; Sodium Channels; Thiazoles | 1990 |
SD-3211, a novel benzothiazine calcium antagonist, alone and in combination with a beta-adrenoceptor antagonist, produces antihypertensive effects without affecting heart rate and atrioventricular conduction in conscious renal hypertensive dogs.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Drug Therapy, Combination; Electrocardiography; Heart Rate; Hypertension, Renal; Male; Propranolol; Thiazoles | 1991 |
Antihypertensive effect of a novel calcium antagonist, SD-3211, in experimental hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Diuretics; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Thiazoles | 1991 |
Anti-ischaemic and vasospasmolytic effects of a novel Ca2+ channel blocker, SD-3211, in vitro.
Topics: 4-Aminopyridine; Amifampridine; Animals; Arteries; Calcium Channel Blockers; Coronary Disease; Coronary Vasospasm; Coronary Vessels; Dogs; In Vitro Techniques; Myocardial Reperfusion; Potassium Channels; Rabbits; Thiazoles; Vasoconstriction | 1991 |
Cardiovascular characterization of SD-3211, a novel benzothiazine calcium channel blocker, in isolated rabbit hearts.
Topics: Animals; Calcium Channel Blockers; Cardiovascular System; Coronary Circulation; Diltiazem; Female; Heart; Male; Myocardial Contraction; Nicardipine; Perfusion; Rabbits; Thiazoles | 1991 |
[Synthesis and calcium antagonistic activities of fecal metabolites of a new calcium antagonist (+)-(R)-3,4-dihydro-2-[5-methoxy-2-[3-[N-methyl-N- [2-[(3,4-methylenedioxy)phenoxy]ethyl]amino]propoxy]phenyl]-4- methyl-3-oxo-2H-1,4-benzothiazine (SD-3211) i
Topics: Animals; Calcium Channel Blockers; Feces; Guinea Pigs; In Vitro Techniques; Thiazoles | 1991 |
Cardiac versus coronary dilator effects of SD-3211, a new nondihydropyridine calcium antagonist, in isolated, blood-perfused dog hearts.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Heart; Heart Conduction System; Injections, Intra-Arterial; Male; Thiazoles | 1990 |
Tissue selectivity of the novel calcium antagonist sesamodil fumarate in isolated smooth muscles and cardiac muscles.
Topics: Animals; Calcimycin; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Rabbits; Swine; Thiazoles; Verapamil | 1990 |
Determination of a new calcium antagonist, sesamodil fumarate (SD-3211), and its metabolite in plasma by liquid chromatography with electrochemical detection.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Electrochemistry; Humans; Kinetics; Molecular Structure; Quality Control; Thiazoles | 1990 |
Antiarrhythmic effects of a benzothiazine derivative (SD-3211) and its stereoisomer (SA3212) in anaesthetized rats and isolated perfused rat hearts compared with bepridil.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Coronary Circulation; Dose-Response Relationship, Drug; Electric Stimulation; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Myocardial Contraction; Perfusion; Rats; Rats, Inbred Strains; Reperfusion; Stereoisomerism; Thiazoles | 1990 |
Allosteric interaction of semotiadil fumarate, a novel benzothiazine, with 1,4-dihydropyridines, phenylalkylamines, and 1,5-benzothiazepines at the Ca(2+)-channel antagonist binding sites in canine skeletal muscle membranes.
Topics: Allosteric Regulation; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dogs; Female; Gallopamil; Isradipine; Kinetics; Male; Membranes; Muscles; Thiazoles | 1994 |
Electrophysiological effects of SD-3212, a novel antiarrhythmic agent, on rabbit hearts in vivo and in vitro.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Male; Microelectrodes; Papillary Muscles; Rabbits; Thiazoles | 1995 |
Effects of semotiadil fumarate, a novel Ca2+ antagonist, on cytosolic Ca2+ level and force of contraction in porcine coronary arteries.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Cytosol; Potassium Chloride; Radioligand Assay; Receptors, Histamine H1; Swine; Thiazoles; Vasoconstriction; Verapamil | 1995 |
Antihypertensive effects of a novel calcium antagonist, semotiadil fumarate (SD-3211), alone and in combination with enalapril or trichlormethiazide in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enalapril; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Thiazoles; Trichlormethiazide | 1994 |
Effects of semotiadil fumarate (SD-3211) and its enantiomer, SD-3212, on the changes in cytosolic Ca2+ and tension caused by KCl and norepinephrine in isolated rat aortas.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Bepridil; Calcium; Calcium Channel Blockers; Cytosol; Diltiazem; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Stereoisomerism; Thiazoles | 1995 |
Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilator action, on guinea-pig ventricular cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Electrophysiology; Female; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Myocardium; Papillary Muscles; Patch-Clamp Techniques; Thiazoles; Vasodilator Agents | 1995 |
Conformational study of 2-phenylbenzothiazine part of SA2995, a Ca2+ antagonist having a benzothiazine skeleton, and structure-activity relationships.
Topics: Animals; Calcium Channel Blockers; Cecum; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Conformation; Structure-Activity Relationship; Thermodynamics; Thiazoles | 1994 |
Comparison of electrophysiologic and hemodynamic effects of SD-3212, a new antiarrhythmic drug, and flecainide in a canine myocardial infarction model.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Flecainide; Heart Conduction System; Hemodynamics; Myocardial Infarction; Thiazoles | 1994 |
Synthesis and in vivo evaluation of [11C]semotiadil, a benzothiazine calcium antagonist.
Topics: Animals; Calcium Channel Blockers; Carbon Radioisotopes; Corpus Striatum; Hippocampus; Hypothalamus; Male; Mice; Thiazoles | 1994 |
Effects of semotiadil fumarate, a novel calcium antagonist, on blood pressure and heart rate in conscious spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Thiazoles | 1993 |
Mechanisms of the inhibitory action of semotiadil fumarate, a novel Ca antagonist, on the voltage-dependent Ca current in smooth muscle cells of the rabbit portal vein.
Topics: Animals; Calcium; Calcium Channel Blockers; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Rabbits; Thiazoles; Vasodilation | 1993 |
Pharmacological profile of semotiadil fumarate, a novel calcium antagonist, in rat experimental angina model.
Topics: Acetylcholine; Angina Pectoris; Animals; Arginine Vasopressin; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Disease Models, Animal; Electrocardiography; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Thiazoles; Vasoconstrictor Agents | 1995 |
Effects of semotiadil, a novel Ca2+ channel antagonist, on the electrical activity of Langendorff-perfused guinea pig hearts in comparison with diltiazem, amlodipine and nifedipine.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Electrocardiography; Female; Guinea Pigs; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Nifedipine; Thiazoles | 1995 |
SD-3212, a new class I and IV antiarrhythmic drug: a potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Bepridil; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cells, Cultured; Guinea Pigs; Heart; Heart Atria; Membrane Potentials; Muscarinic Agonists; Muscarinic Antagonists; Myocardium; Potassium; Potassium Channels; Sodium; Sodium Channels; Thiazoles | 1995 |
Negative dromotropic effects of class I antiarrhythmic drugs in anisotropic ventricular muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Calcium Channel Blockers; Dose-Response Relationship, Drug; Flecainide; Heart Conduction System; In Vitro Techniques; Membrane Potentials; Quinidine; Rabbits; Sodium Channels; Thiazoles | 1996 |
Semotiadil improves survival of rats with monocrotaline-induced pulmonary hypertension: comparison with diltiazem.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart; Hypertension, Pulmonary; Male; Monocrotaline; Rats; Rats, Wistar; Thiazoles | 1996 |
Biliary metabolites of semotiadil fumarate in the rat.
Topics: Animals; Bile; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Glucuronates; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Oxidation-Reduction; Rats; Rats, Wistar; Spectrometry, Mass, Fast Atom Bombardment; Thiazoles | 1995 |
Semotiadil inhibits the development of right ventricular hypertrophy and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Pulmonary Artery; Rats; Rats, Wistar; Thiazoles | 1995 |
Quantitative structure-activity relationships of Ca(2+)-antagonistic semotiadil congeners.
Topics: Animals; Calcium Channel Blockers; Guinea Pigs; In Vitro Techniques; Molecular Conformation; Structure-Activity Relationship; Thiazoles | 1996 |
A novel benzothiazine Ca2+ channel antagonist, semotiadil, inhibits cardiac L-type Ca2+ currents.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Guinea Pigs; Membrane Potentials; Myocardium; Thiazoles | 1997 |
Electrophysiologic effects of SD-3212, a new class I antiarrhythmic drug, on canine atrial flutter and atrial action-potential characteristics.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atrial Flutter; Atrial Function; Calcium Channel Blockers; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Heart Atria; Heart Conduction System; Sodium Channel Blockers; Thiazoles | 1997 |
Enantioselective local disposition of semotiadil (R-enantiomer) and levosemotiadil (S-enantiomer) in perfused rat liver.
Topics: Animals; Calcium Channel Blockers; Evans Blue; Liver; Male; Perfusion; Rats; Rats, Wistar; Serum Albumin, Bovine; Stereoisomerism; Thiazoles | 1997 |
Enantioselective protein binding of semotiadil and levosemotiadil determined by high-performance frontal analysis.
Topics: Blood Proteins; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Online Systems; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Stereoisomerism; Thiazoles | 1997 |
Photochemical identification of transmembrane segment IVS6 as the binding region of semotiadil, a new modulator for the L-type voltage-dependent Ca2+ channel.
Topics: Animals; Azides; Binding Sites; Calcium Channel Blockers; Cell Membrane; Cyanogen Bromide; Metalloendopeptidases; Muscle, Skeletal; Peptide Mapping; Photoaffinity Labels; Rabbits; Thiazines; Thiazoles; Tritium; Trypsin | 1998 |
Photochemical localization of the semotiadil binding region within the cardiac Ca2+ channel alpha1 subunit. Comparison with the skeletal muscle counterpart.
Topics: Amino Acid Sequence; Animals; Azides; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Isradipine; Kinetics; Macromolecular Substances; Molecular Sequence Data; Muscle, Skeletal; Myocardium; Peptide Fragments; Photoaffinity Labels; Photochemistry; Swine; Thiazines; Thiazoles | 1998 |
Binding study of semotiadil and levosemotiadil with alpha(1)-acid glycoprotein using high-performance frontal analysis.
Topics: Calcium Channel Blockers; Calibration; Chromatography, High Pressure Liquid; Humans; Kinetics; Online Systems; Orosomucoid; Protein Binding; Regression Analysis; Spectrophotometry, Ultraviolet; Stereoisomerism; Thiazoles | 1999 |
Semotiadil, a new calcium antagonist, is a very potent inhibitor of LDL-oxidation.
Topics: Adult; Amidines; Azo Compounds; Calcium Channel Blockers; Copper; Dinoprost; F2-Isoprostanes; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitriles; Oxidants; Oxidation-Reduction; Thiazoles; Thiobarbituric Acid Reactive Substances | 1999 |
Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Mixed Function Oxygenases; Steroid Hydroxylases; Structure-Activity Relationship; Thiazoles | 1999 |
Efficacy of the novel calcium antagonist R(+)-semotiadil in limiting the ventricular rate during atrial flutter in isolated guinea pig hearts.
Topics: Animals; Atrial Flutter; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; In Vitro Techniques; Male; Thiazoles; Time Factors; Ventricular Function; Verapamil | 2000 |
Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats.
Topics: Animals; Calcium Channel Blockers; Female; Glucuronosyltransferase; Hyperplasia; Hypertrophy; Liver; Microsomes, Liver; Nicardipine; Phenobarbital; Propylthiouracil; Rats; Rats, Wistar; Thiazoles; Thyroid Diseases; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 2000 |
Effects of semotiadil, a novel calcium antagonist, on the retina and optic nerve head circulation.
Topics: Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Heart Rate; Injections, Intravenous; Intraocular Pressure; Optic Disk; Rabbits; Retina; Thiazoles | 2000 |
Efficient identification of photolabelled amino acid residues by combining immunoaffinity purification with MS: revealing the semotiadil-binding site and its relevance to binding sites for myristates in domain III of human serum albumin.
Topics: Affinity Labels; Amino Acid Sequence; Amino Acids; Azides; Binding Sites; Chromatography, Affinity; Humans; In Vitro Techniques; Ligands; Models, Molecular; Molecular Sequence Data; Myristates; Peptide Fragments; Photochemistry; Protein Conformation; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazines; Thiazoles | 2002 |
Antiplatelet activity of semotiadil fumarate.
Topics: Adenosine Diphosphate; Adult; Amlodipine; Calcium Channel Blockers; Case-Control Studies; Collagen; Diltiazem; Humans; Hypertension; Middle Aged; Nifedipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiazoles | 2002 |
Combined sodium and calcium channel blockade in prevention of lethal arrhythmias.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Death, Sudden, Cardiac; Depression, Chemical; Dogs; Drug Synergism; Drug Therapy, Combination; Heart Rate; Isoproterenol; Myocardial Infarction; Physical Conditioning, Animal; Propranolol; Sodium Channel Blockers; Thiazoles; Ventricular Fibrillation | 2003 |