Page last updated: 2024-08-24

sertindole and clozapine

sertindole has been researched along with clozapine in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	22 (29.73)	18.2507
2000's	29 (39.19)	29.6817
2010's	20 (27.03)	24.3611
2020's	3 (4.05)	2.80

Authors

Authors	Studies
Arnt, J; Bøgesø, KP; Hyttel, J; Perregaard, J; Sánchez, C	1
De Loore, K; Gommeren, W; Janssen, PF; Lesage, AS; Leysen, JE; Luyten, WH; Schotte, A; Van Gompel, P	1
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L	1
Grinde, E; Herrick-Davis, K; Teitler, M	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Andersen, K; Balle, T; Larsen, AK; Liljefors, T; Perregaard, J; Ramirez, MT; Søby, KK	1
Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S	1
Keserü, GM	1
Wermuth, CG	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR	1
Jia, L; Sun, H	1
Caron, G; Ermondi, G; Visentin, S	1
Giordanetto, F; Leach, AG; Zachariae, U	1
Jensen, AA; Kehler, J; Krogsgaard-Larsen, N	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Sen, S; Sinha, N	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A	1
Skarsfeldt, T	2
Arnt, J	1
Casey, DE	2
Tamminga, CA	1
Fogelson, DL; Payne, D; Sternbach, H	1
Schooler, NR	1
Daniel, DG; Whitcomb, SR	1
Lieberman, JA; Perkins, DO	1
Pollock, BG; Sweet, RA	1
Altshuler, LL; Corá-Locatelli, G; Denicoff, K; Dunn, RT; Frye, MA; Ketter, TA; Kimbrell, TA; Post, RM	1
Asenbaum, S; Barnas, C; Brücke, T; Hesselmann, B; Kasper, S; Küfferle, B; Podreka, I; Tauscher, J	1
Depoortere, R; Perrault, G; Sanger, DJ	1
Drici, MD; Flockhart, DA; Liu, XK; Wang, WX; Woosley, RL	1
Berisford, MA; Goldstein, D; Kysar, L; Marder, SR; Mintz, J; Pashdag, J; Wirshing, DA; Wirshing, WC	1
Baker, GB; Chue, PS; Prior, TI; Tibbo, P	1
Bayle, FJ; Ghaoui, S; Olie, JP	1
Kulkarni, SK; Ninan, I	1
Berecz, R; de la Rubia, A; Degrell, I; Glaub, T; Kellermann, M; Llerena, A	1
Philibin, SD; Porter, JH; Vann, RE; Varvel, SA; Wise, LE	2
Möller, HJ	1
McAskill, R; Taylor, DM	1
Bebbington, P; Freemantle, N; Geddes, J; Harrison, P	1
Kapur, S; Remington, G	1
Agelink, MW; Klieser, E; Linka, T; Lukas, K; Majewski, T; Ullrich, H; Wurthmann, C	1
Hilger, E; Kasper, S	1
Revicki, DA	1
Hedges, D; Jeppson, K; Whitehead, P	1
Bryois, Ch; Sahli, Ch	1
Arnt, J; Didriksen, M; Kreilgaard, M	1
Hertel, P	1
Arnt, J; Didriksen, M; Skarsfeldt, T	1
Brennum, LT; Kreilgaard, M; Olsen, CK	1
Friedemann, J; Hanisch, F; Pillmann, F	1
Davis, JM; Hunger, H; Kissling, W; Komossa, K; Leucht, S; Lobos, CA; Rummel-Kluge, C; Schmid, F; Schwarz, S	1
Arnt, J; Calcagno, E; Carli, M; Invernizzi, RW; Mainini, E	1
Hunger, H; Kissling, W; Komossa, K; Leucht, S; Rummel-Kluge, C; Schmid, F; Schwarz, S	1
Akar, FY; Celikyurt, IK; Erden, F; Mutlu, O; Ulak, G	1
Friis, S; Haahr, U; Johannessen, JO; Larsen, TK; McGlashan, TH; Melle, I; Opjordsmoen, S; Rund, BR; Simonsen, E; Vaglum, P	1
Akar, FY; Celikyurt, IK; Erden, F; Mutlu, O; Tanyeri, P; Ulak, G	1
Grabski, B; Siwek, M; Woroń, J	1
Levander, S; Nielsen, J; Nielsen, RE; Thode, D	1
Aagaard, J; Andersen, T; Damkier, P; Dybbro, J; Emborg, C; Fabricius, S; Glyngdal, P; Gydesen, S; Haderup, K; Lublin, H; Nielsen, J; Taylor, D; Thode, D	1
Levander, S; Lindström, E; Nielsen, J; Nielsen, RE	1
Blagojević, D; Lečić-Toševski, D; Miljević, Č; Niketić, V; Nikolić, M; Nikolić-Kokić, A; Spasić, MB	1
Blagojević, D; Mijušković, A; Miler, M; Miljević, Č; Milošević, V; Nestorov, J; Nikolić, M; Nikolić-Kokić, A; Oreščanin-Dušić, Z; Spasić, M; Tatalović, N	1
Blagojević, D; Mijović, M; Mijusković, A; Miler, M; Miljević, Č; Milošević, V; Nestorov, J; Nikolić, M; Nikolić-Kokić, A; Oreščanin-Dušić, Z; Spasić, M; Tatalović, N	1
Davis, JM; Leucht, S; Smith, RC	1
Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S	1
Blagojević, D; Brkljačić, J; Miler, M; Miljević, Č; Milošević, V; Nikolić, M; Nikolić-Kokić, A; Oreščanin-Dušić, Z; Platanić Arizanović, L; Spasić, S; Tatalović, N; Vidonja Uzelac, T	1
Cvijetić, I; Gligorijević, N; Kokić, AN; Mijatović, A; Miljević, Č; Minić, S; Nikolić, M; Platanić Arizanović, L; Ristivojević, MK	1

Reviews

23 review(s) available for sertindole and clozapine

Article	Year
Selective optimization of side activities: another way for drug discovery. Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6 Topics: Animals; Biological Availability; Combinatorial Chemistry Techniques; Databases, Factual; Drug Design; Humans; Patents as Topic; Pharmaceutical Preparations; Structure-Activity Relationship	2004
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents. Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Humans; Hypertension; Molecular Structure; Receptors, Adrenergic, alpha-1; Risk Factors; Stereoisomerism; Structure-Activity Relationship	2008
Side effect profiles of new antipsychotic agents. The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 11 Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Dyskinesia, Drug-Induced; Humans; Imidazoles; Indoles; Neuroleptic Malignant Syndrome; Olanzapine; Pirenzepine; Psychotic Disorders; Risperidone; Schizophrenia; Seizures; Sleep; Weight Gain	1996
The promise of new drugs for schizophrenia treatment. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1997, Volume: 42, Issue:3 Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome	1997
New antipsychotic medications: strategies for evaluation and selected findings. Schizophrenia research, 1997, Oct-30, Volume: 27, Issue:2-3 Topics: Antipsychotic Agents; Benzodiazepines; Chronic Disease; Clinical Trials as Topic; Clozapine; Drug Administration Schedule; Drug Approval; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Placebos; Psychotic Disorders; Recurrence; Research Design; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; United States; United States Food and Drug Administration	1997
Treatment of the refractory schizophrenic patient. The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 1 Topics: Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Clozapine; Diagnosis, Differential; Humans; Imidazoles; Indoles; Olanzapine; Patient Compliance; Pirenzepine; Psychiatric Status Rating Scales; Receptors, Dopamine D2; Risperidone; Schizophrenia; Schizophrenic Psychology; Terminology as Topic; Treatment Failure	1998
New atypical antipsychotics. Experience and utility in the elderly. Drugs & aging, 1998, Volume: 12, Issue:2 Topics: Aged; Aging; Antipsychotic Agents; Benzodiazepines; Clozapine; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Randomized Controlled Trials as Topic; Risperidone; Treatment Outcome	1998
Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics. Journal of affective disorders, 1998, Volume: 48, Issue:2-3 Topics: Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clozapine; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Risperidone; Trimipramine	1998
Drug metabolism and atypical antipsychotics. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:4 Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cytochrome P-450 Enzyme System; Dibenzothiazepines; Drug Interactions; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Quetiapine Fumarate; Risperidone; Schizophrenia	1999
[New antipsychotic agents]. L'Encephale, 1999, Volume: 25 Spec No 3 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Psychotic Disorders; Quetiapine Fumarate; Risperidone; Sulpiride; Thiazoles	1999
[New i.e. atypical neuroleptic agents for negative symptoms of schizophrenia: results and methodological problems of evaluation]. Der Nervenarzt, 2000, Volume: 71, Issue:5 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins; Double-Blind Method; Dyskinesia, Drug-Induced; Humans; Imidazoles; Indoles; Neurotransmitter Agents; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Schizophrenic Psychology; Sulpiride; Thiazoles	2000
Atypical antipsychotics and weight gain--a systematic review. Acta psychiatrica Scandinavica, 2000, Volume: 101, Issue:6 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Risperidone; Sulpiride; Thiazoles; Weight Gain	2000
Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis. BMJ (Clinical research ed.), 2000, Dec-02, Volume: 321, Issue:7273 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Drug Costs; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Quetiapine Fumarate; Regression Analysis; Risperidone; Schizophrenia; Sulpiride	2000
Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia. Annual review of medicine, 2001, Volume: 52 Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins; Dopamine Antagonists; Drug Monitoring; Haloperidol; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Receptors, Dopamine D2; Receptors, Dopamine D4; Risperidone; Schizophrenia; Schizophrenic Psychology; Serotonin Antagonists; Sulpiride; Thiazoles; Treatment Outcome	2001
[Atypical neuroleptics: new approaches to drug therapy of schizophrenic disorders]. Wiener klinische Wochenschrift, 2000, Dec-22, Volume: 112, Issue:24 Topics: Aged; Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Controlled Clinical Trials as Topic; Dibenzothiazepines; Dibenzothiepins; Haloperidol; Humans; Imidazoles; Indoles; Multicenter Studies as Topic; Olanzapine; Piperazines; Pirenzepine; Placebos; Quetiapine Fumarate; Risperidone; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sulpiride; Thiazoles	2000
Cost effectiveness of the newer atypical antipsychotics: a review of the pharmacoeconomic research evidence. Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:1 Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cost-Benefit Analysis; Dibenzothiazepines; Health Care Costs; Humans; Imidazoles; Indoles; Olanzapine; Pirenzepine; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Risperidone	2001
Antipsychotic medication and seizures: a review. Drugs of today (Barcelona, Spain : 1998), 2003, Volume: 39, Issue:7 Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dibenzothiazepines; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Quinolones; Risperidone; Seizures; Thiazoles	2003
[Psychotropics and weight gain]. Praxis, 2004, Aug-25, Volume: 93, Issue:35 Topics: Adolescent; Adult; Amisulpride; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Body Mass Index; Child; Clozapine; Dibenzothiazepines; Double-Blind Method; Female; Fructose; Haloperidol; Humans; Imidazoles; Indoles; Male; Obesity; Olanzapine; Piperazines; Placebos; Psychotropic Drugs; Quetiapine Fumarate; Quinolones; Randomized Controlled Trials as Topic; Risperidone; Socioeconomic Factors; Sulpiride; Thiazoles; Time Factors; Topiramate; Valproic Acid; Weight Gain	2004
Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophrenia research, 2010, Volume: 123, Issue:2-3 Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Blood Glucose; Cholesterol; Clinical Trials as Topic; Clozapine; Dibenzothiazepines; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Sulpiride; Thiazoles; Weight Gain	2010
Risperidone versus other atypical antipsychotics for schizophrenia. The Cochrane database of systematic reviews, 2011, Jan-19, Issue:1 Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Sulpiride; Thiazoles	2011
[Pharmacoepidemiological and toxicological aspects of atypical neuroleptics usage]. Przeglad lekarski, 2011, Volume: 68, Issue:8 Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Drug Interactions; Humans; Imidazoles; Indoles; Olanzapine	2011
Maximizing response to first-line antipsychotics in schizophrenia: a review focused on finding from meta-analysis. Psychopharmacology, 2019, Volume: 236, Issue:2 Topics: Amisulpride; Antidepressive Agents; Antipsychotic Agents; Clozapine; Depression; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome	2019
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia. The American journal of psychiatry, 2020, 04-01, Volume: 177, Issue:4 Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes	2020

Trials

4 trial(s) available for sertindole and clozapine

Article	Year
Novel antipsychotics: comparison of weight gain liabilities. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:6 Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Haloperidol; Humans; Imidazoles; Indoles; Male; Obesity; Olanzapine; Pirenzepine; Placebos; Retrospective Studies; Risperidone; Schizophrenia; Weight Gain	1999
Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine. Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:1 Topics: Adult; Amisulpride; Antipsychotic Agents; Autonomic Nervous System; Benzodiazepines; Clozapine; Electrocardiography; Female; Heart; Heart Rate; Humans; Imidazoles; Indoles; Male; Middle Aged; Olanzapine; Pirenzepine; Prospective Studies; Sulpiride	2001
Effects of sertindole on cognition in clozapine-treated schizophrenia patients. Acta psychiatrica Scandinavica, 2012, Volume: 126, Issue:1 Topics: Adult; Antipsychotic Agents; Clozapine; Cognition Disorders; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Imidazoles; Indoles; Male; Neuropsychological Tests; Psychiatric Status Rating Scales; Schizophrenia	2012
Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study. Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:2 Topics: Adult; Antipsychotic Agents; Clozapine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Imidazoles; Indoles; Male; Middle Aged; Psychiatric Status Rating Scales; Quality of Life; Schizophrenia; Treatment Outcome	2012

Other Studies

47 other study(ies) available for sertindole and clozapine

Article	Year
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. Journal of medicinal chemistry, 1992, Mar-20, Volume: 35, Issue:6 Topics: Animals; Antipsychotic Agents; Dopamine Antagonists; Imidazoles; Indoles; Male; Mice; Piperazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship	1992
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology, 1996, Volume: 124, Issue:1-2 Topics: Animals; Antipsychotic Agents; Brain; Cells, Cultured; Clozapine; Haloperidol; Humans; Male; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone	1996
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3 Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes	1998
Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Animals; Antipsychotic Agents; COS Cells; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Radioligand Assay; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Receptor Agonists	2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists. Journal of medicinal chemistry, 2003, Jan-16, Volume: 46, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Azoles; Brain; Cell Line; Cricetinae; Humans; Imidazoles; In Vitro Techniques; Indoles; Pyridines; Pyrimidines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship; Triazoles	2003
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:3 Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14 Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation	2009
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18 Topics: Cell Line; HeLa Cells; Humans; Indoles; Ligands; Protein Binding; Pyrazines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Structure-Activity Relationship	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia. Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides	2014
Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: acute and repeated treatment. Synapse (New York, N.Y.), 1992, Volume: 10, Issue:1 Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dextroamphetamine; Dopamine; Drug Administration Schedule; Electrophysiology; Haloperidol; Imidazoles; Indoles; Male; Mesencephalon; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra; Tegmentum Mesencephali	1992
Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine. European journal of pharmacology, 1995, Sep-05, Volume: 283, Issue:1-3 Topics: Animals; Antipsychotic Agents; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imidazoles; Indoles; Locomotion; Male; Motor Activity; Prazosin; Rats; Rats, Wistar; Ritanserin	1995
Comparison of short-term administration of sertindole, clozapine and haloperidol on the inactivation of midbrain dopamine neurons in the rat. European journal of pharmacology, 1994, Mar-21, Volume: 254, Issue:3 Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Imidazoles; Indoles; Male; Rats; Rats, Wistar; Substantia Nigra; Ventral Tegmental Area	1994
Behavioral effects of sertindole, risperidone, clozapine and haloperidol in Cebus monkeys. Psychopharmacology, 1996, Volume: 124, Issue:1-2 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cebus; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Risperidone	1996
A naturalistic pilot study comparing haloperidol, clozapine, sertindole, and risperidone in partially responsive chronic schizophrenia or schizoaffective disorder. Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:6 Topics: Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Imidazoles; Indoles; Male; Psychotic Disorders; Risperidone; Schizophrenia; Treatment Failure	1997
Medical complications and selectivity of therapeutic response to atypical antipsychotic drugs. The American journal of psychiatry, 1998, Volume: 155, Issue:2 Topics: Adult; Antipsychotic Agents; Clozapine; Drug Overdose; Humans; Imidazoles; Indoles; Male; Schizophrenia; Schizophrenic Psychology	1998
Sertindole and dopamine D2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - a 123I-IBZM SPECT study. Psychopharmacology, 1998, Volume: 136, Issue:4 Topics: Adult; Antipsychotic Agents; Benzamides; Clozapine; Female; Haloperidol; Humans; Imidazoles; Indoles; Iodine Radioisotopes; Male; Middle Aged; Neostriatum; Pyrrolidines; Receptors, Dopamine D2; Risperidone; Schizophrenia; Tomography, Emission-Computed, Single-Photon	1998
Some, but not all, antipsychotic drugs potentiate a low level of prepulse inhibition shown by rats of the Wistar strain. Behavioural pharmacology, 1997, Volume: 8, Issue:4 Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Benzodiazepines; Clozapine; Haloperidol; Imidazoles; Indoles; Injections, Intraperitoneal; Male; Neural Inhibition; Olanzapine; Pirenzepine; Prazosin; Rats; Rats, Wistar; Reflex, Startle; Remoxipride; Risperidone; Ritanserin; Serotonin Antagonists	1997
Prolongation of QT interval in isolated feline hearts by antipsychotic drugs. Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:6 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Cats; Clozapine; Electrocardiography; Haloperidol; Heart; Humans; Imidazoles; In Vitro Techniques; Indoles; Risperidone	1998
Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics. Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:9 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzodiazepines; Catalepsy; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Indoles; Ketanserin; Male; Mice; Mice, Inbred BALB C; Olanzapine; Pirenzepine; Quinpirole; Random Allocation; Rats; Rats, Wistar; Risperidone; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity	1999
Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient. Pharmacopsychiatry, 2000, Volume: 33, Issue:1 Topics: Adult; Antipsychotic Agents; Clozapine; Humans; Imidazoles; Indoles; Male; Psychiatric Status Rating Scales; Schizophrenia, Paranoid; Schizophrenic Psychology; Substance Withdrawal Syndrome	2000
Clozapine discrimination with a low training dose distinguishes atypical from typical antipsychotic drugs in rats. Psychopharmacology, 2000, Volume: 149, Issue:2 Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Discrimination Learning; Imidazoles; Indoles; Male; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Risperidone	2000
Effects of antipsychotic drugs on operant responding after acute and repeated administration. Psychopharmacology, 2002, Volume: 160, Issue:2 Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Conditioning, Operant; Dibenzothiazepines; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Olanzapine; Pirenzepine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Remoxipride; Risperidone; Thioridazine; Time Factors	2002
Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment. European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Imidazoles; Indoles; Male; Maze Learning; Olanzapine; Psychomotor Performance; Rats; Rats, Wistar; Time Factors	2006
Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action. Synapse (New York, N.Y.), 2006, Dec-01, Volume: 60, Issue:7 Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Dopamine Agents; Efferent Pathways; Haloperidol; Imidazoles; Indoles; Limbic System; Male; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Agents; Synaptic Transmission	2006
Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics. Psychopharmacology, 2007, Volume: 193, Issue:2 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Maze Learning; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenic Psychology	2007
Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics. European journal of pharmacology, 2008, Apr-28, Volume: 584, Issue:2-3 Topics: Administration, Oral; Animals; Antipsychotic Agents; Basal Ganglia; Behavior, Animal; Benzodiazepines; Binding, Competitive; Clozapine; Conditioning, Psychological; Dopamine Antagonists; Haloperidol; Imidazoles; Indoles; Injections, Subcutaneous; Male; Models, Biological; Olanzapine; Protein Binding; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D2; Reproducibility of Results; Risperidone	2008
Combined treatment with quetiapine and sertindole in therapy refractory insomnia after clozapine discontinuation. Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:11 Topics: Antipsychotic Agents; Clozapine; Dibenzothiazepines; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Imidazoles; Indoles; Male; Middle Aged; Polysomnography; Quetiapine Fumarate; Schizophrenia; Sleep; Sleep Initiation and Maintenance Disorders	2010
Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP. Psychopharmacology, 2011, Volume: 214, Issue:3 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Choice Behavior; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Imidazoles; Indoles; Male; Microdialysis; Neuropsychological Tests; Photic Stimulation; Piperazines; Rats; Rats, Sprague-Dawley; Reaction Time	2011
Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice. Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:3 Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Imidazoles; Indoles; Learning; Male; Maze Learning; Memory; Mice; Mice, Inbred BALB C; Olanzapine	2011
Stability of medication in early psychosis: a comparison between second-generation and low-dose first-generation antipsychotics. Early intervention in psychiatry, 2009, Volume: 3, Issue:1 Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Chi-Square Distribution; Clopenthixol; Clozapine; Female; Humans; Imidazoles; Indoles; Kaplan-Meier Estimate; Male; Middle Aged; Olanzapine; Perphenazine; Psychotic Disorders; Risperidone; Statistics, Nonparametric; Time Factors; Young Adult	2009
Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice. Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:4 Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Imidazoles; Indoles; Learning; Male; Memory Disorders; Mice; Mice, Inbred BALB C; Motor Activity; Olanzapine; Recognition, Psychology; Visual Perception	2011
DAI-10 is as good as DAI-30 in schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:10 Topics: Adult; Antipsychotic Agents; Attitude to Health; Clozapine; Cognitive Science; Drug Therapy, Combination; Female; Humans; Imidazoles; Indoles; Male; Medication Adherence; Middle Aged; Pharmacology, Clinical; Psychiatric Status Rating Scales; Psychometrics; Reproducibility of Results; Schizophrenia; Schizophrenic Psychology; Self Report; Work Simplification	2012
Effect of atypical antipsychotics on antioxidant enzyme activities in human erythrocytes (in vitro study). Human psychopharmacology, 2013, Volume: 28, Issue:1 Topics: Adult; Amisulpride; Antioxidants; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Catalase; Clozapine; Dibenzothiazepines; Enzyme Activation; Erythrocytes; Glutathione Peroxidase; Glutathione Reductase; Humans; Imidazoles; Indoles; Male; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Sulpiride; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Treatment Outcome; Young Adult	2013
Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney. Journal of toxicology and environmental health. Part A, 2016, Volume: 79, Issue:20 Topics: Animals; Antioxidants; Antipsychotic Agents; Clozapine; Imidazoles; Indoles; Kidney; Male; Oxidative Stress; Piperazines; Random Allocation; Rats; Rats, Wistar; Thiazoles	2016
Clozapine, ziprasidone, and sertindole-induced morphological changes in the rat heart and their relationship to antioxidant enzymes function. Journal of toxicology and environmental health. Part A, 2018, Volume: 81, Issue:17 Topics: Animals; Antioxidants; Antipsychotic Agents; Clozapine; Heart; Imidazoles; Indoles; Male; Myocardium; Oxidation-Reduction; Piperazines; Rats; Rats, Wistar; Thiazoles	2018
Effects of several atypical antipsychotics closapine, sertindole or ziprasidone on hepatic antioxidant enzymes: Possible role in drug-induced liver dysfunction. Journal of toxicology and environmental health. Part A, 2021, 02-16, Volume: 84, Issue:4 Topics: Animals; Antioxidants; Antipsychotic Agents; Clozapine; Imidazoles; Indoles; Liver; Liver Diseases; Male; Piperazines; Rats; Rats, Wistar; Thiazoles	2021
Human Hemoglobin and Antipsychotics Clozapine, Ziprasidone and Sertindole: Friends or Foes? International journal of molecular sciences, 2023, May-17, Volume: 24, Issue:10 Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Humans; Molecular Docking Simulation; Olanzapine	2023