serine has been researched along with wortmannin in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (11.11) | 18.2507 |
| 2000's | 64 (79.01) | 29.6817 |
| 2010's | 8 (9.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J | 1 |
| Dong, LQ; Du, H; Fan, J; Kolakowski, LF; Lee, AV; Liu, F; Mandarino, J; Mandarino, LJ; Porter, SG; Yee, D | 1 |
| Chun, RF; Jeang, KT; Neuveut, C; Semmes, OJ | 1 |
| Aizu-Yokota, E; Kasahara, T; Matsumoto, Y; Sonoda, Y; Watanabe, S | 1 |
| Accili, D; Nakae, J; Park, BC | 1 |
| Cichy, SC; Cohen, P; Guo, S; Rena, G; Unterman, TG | 1 |
| Filippa, N; Filloux, C; Hemmings, B; Sable, CL; Van Obberghen, E | 1 |
| Busse, R; Dimmeler, S; Fisslthaler, B; Fleming, I; Hermann, C; Zeiher, AM | 1 |
| Flechner, L; Franke, TF; Hyun, T; Li, W; Pierce, JH; Yam, A; Zhang, J | 1 |
| Busse, R; Dimmeler, S; Fisslthaler, B; Fleming, I; Hermann, C | 1 |
| Beal, PA; Comb, MJ; Peterson, RT; Schreiber, SL | 1 |
| Bargonetti, J; Chicas, A; Kramer, FR; Olivier, M; Taya, Y; Tyagi, S; Xiao, G | 1 |
| Kamitori, K; Kohsaka, S; Machide, M | 1 |
| Birnbaum, MJ; Gaslightwala, I; Nakagawa, H; Okano, J; Rustgi, AK | 1 |
| Kar, S; Quirion, R; Zheng, WH | 1 |
| Dunlap, JA; Lowe, WL; Yorek, MA | 1 |
| Adachi, K; Hayakawa, J; Hisamoto, K; Kanda, Y; Kanzaki, T; Kurachi, H; Murata, Y; Nishio, Y; Ohmichi, M; Tasaka, K | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Alt, A; Herschkovitz, A; Kuroki, T; LeRoith, D; Liu, YF; Ohba, M; Paz, K; Sampson, SR; Tennenbaum, T; Zick, Y | 1 |
| Igisu, H; Matsuoka, M | 1 |
| Fukunaga, K; Hamada , J; Hara, T; Kai, Y; Kawano, T; Miyamoto, E; Morioka, M; Ushio, Y; Yano, S | 1 |
| Badorff, C; Dimmeler, S; Holzmann, Y; Rössig, L; Zeiher, AM | 1 |
| Daly, RJ; Lynch, DK | 1 |
| Aschenbach, WG; Goodyear, LJ; Hirshman, MF; Sakamoto, K | 1 |
| Anderson, CW; Appella, E; Goodarzi, AA; Higashimoto, Y; Lees-Miller, SP; Noda, Y; Saito, S | 1 |
| Brennan, P; Cantrell, D; Dennis, PB; Pullen, N; Saitoh, M; Thomas, G | 1 |
| Enomoto, A; Hosoi, Y; Ishii, N; Matsumoto, Y; Miyachi, H; Nakagawa, K; Ono, T; Suzuki, N; Yamada, S; Yoshida, M | 1 |
| Crow, MT; Jo, SH; Leblais, V; Wang, PH; Xiao, RP | 1 |
| Golan, DE; Gonzalez, E; Kou, R; Lin, AJ; Michel, T | 1 |
| Ali, A; Huang, WC; Lin, WW; Wen, HC; Woodgett, JR | 1 |
| Bazan, NG; Bernatchez, PN; Gélinas, DS; Rollin, S; Sirois, MG | 1 |
| Czubayko, F; Franke, TF; List, HJ; Martin, MB; Morgan, E; Reiter, R; Stoica, A; Stoica, GE; Wellstein, A | 1 |
| Broussard, SR; Burgess, W; Dantzer, R; Jesse, K; Kelley, KW; Tang, Q | 1 |
| Guan, KL; Inoki, K; Li, Y; Vacratsis, P | 1 |
| Oehrl, W; Rubio, I; Wetzker, R | 1 |
| Hresko, RC; Mueckler, M; Murata, H | 1 |
| Kupferwasser, D; Lam, J; Lee-Fruman, KK; Phin, S | 1 |
| Bai, RY; Bassermann, F; Duyster, J; Klumpen, S; Miething, C; Morris, SW; Ouyang, T; Peschel, C; von Klitzing, C | 1 |
| Billings, E; Kristof, AS; Marks-Konczalik, J; Moss, J | 1 |
| Beguinot, F; Cassese, A; Condorelli, G; Formisano, P; Giacco, F; Miele, C; Oriente, F; Perfetti, A; Santopietro, S; Trencia, A; Vigliotta, G | 1 |
| Han, DH; Hansen, PA; Holloszy, JO; Hucker, KA; Nolte, LA | 1 |
| Das, KC; Dashnamoorthy, R | 1 |
| Giraud, J; Lee, YH; Leshan, R; White, MF | 1 |
| Bird, IM; Li, Y; Magness, RR; Zheng, J | 1 |
| Deng, HM; Li, HL; Liu, SJ; Netzer, WJ; Wang, JZ; Wang, Q; Xu, H; Zhang, AH | 1 |
| Bijur, GN; Jope, RS | 1 |
| Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM | 1 |
| Garnovskaya, MN; Grewal, JS; Mukhin, YV; Raymond, JR; Tholanikunnel, BG; Ullian, ME; Vlasova, TM | 1 |
| Fan, RS; Hunger-Glaser, I; Perez-Salazar, E; Rozengurt, E | 1 |
| Goodarzi, AA; Lees-Miller, SP | 1 |
| Douglas, P; Kurz, EU; Lees-Miller, SP | 1 |
| Baker, AF; Coon, A; Gard, JM; George, BL; Ihle, N; Kirkpatrick, L; Mahadevan, D; Meuillet, EJ; Powis, G; Stamper, C; Williams, R | 1 |
| Bai, RY; Bassermann, F; Duyster, J; Münch, S; Peschel, C; Urschel, S | 1 |
| Juhnn, YS; Kang, UG; Kim, SY; Kim, Y; Kim, YS; Lee, YI; Seo, M | 1 |
| McMahon, SB; Pezet, S; Spyropoulos, A; Williams, RJ | 1 |
| Wang, MH; Xu, XM; Zhou, YQ | 1 |
| Blenis, J; Holz, MK | 1 |
| Brennesvik, EO; Jebens, E; Jensen, J; Ktori, C; Ruzzin, J; Shepherd, PR | 1 |
| Beck, A; Fiedler, H; Häring, HU; Kellerer, M; Moeschel, K; Müssig, K; Staiger, H | 1 |
| Jayatilleke, A; Madamanchi, A; Naga Prasad, SV; Rockman, HA | 1 |
| Misra, UK; Pizzo, SV | 1 |
| Kucerová, D; Sloncová, E; Tuhácková, Z; Turecková, J; Vojtechová, M | 1 |
| Hers, I; Homma, Y; Tavaré, JM; Wherlock, M; Yagisawa, H | 1 |
| Gamo, K; Gartler, SM; Gatti, RA; Goldstine, JV; Hansen, RS; Marahrens, Y; Nahas, S; Roelfsema, JH | 1 |
| Komori, K; Naruse, K; Nimura, Y; Nishikimi, N; Sokabe, M; Takeda, H | 1 |
| Kumagai, Y; Sumi, D; Sun, Y | 1 |
| Ewart, MA; Hardie, DG; Reihill, JA; Salt, IP | 1 |
| Inageda, K; Matsuoka, M; Nishitai, G; Suzuki, K | 1 |
| Bahr, SM; Brat, D; Gutmann, DH; Jang, SW; Liu, Z; Sun, SY; Tang, X; Wang, X; Ye, K | 1 |
| Fichtman, B; Horowitz, M; Rapaport, D; Ravid, L | 1 |
| Bagetta, G; Berliocchi, L; Cavaliere, F; Corasaniti, MT; Gliozzi, M; Mazzei, C; Morrone, LA; Nucci, C; Rotiroti, D; Russo, R; Tassorelli, C | 1 |
| Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H | 1 |
| An, D; Feener, EP; Goodyear, LJ; Hirshman, MF; Koh, HJ; Taylor, EB; Toyoda, T; Treebak, JT; Witczak, CA; Wojtaszewski, JF; Xie, J | 1 |
| Diamant, M; Guigas, B; Jazet, IM; Kriek, J; Maassen, JA; Nascimento, EB; Ouwens, DM; Snel, M; van der Zon, GC | 1 |
| Acevedo-Duncan, M; Desai, S; Pillai, P; Win-Piazza, H | 1 |
| Kawai, T; Matsuwaki, T; Nedachi, T; Nishihara, M; Yamanouchi, K | 1 |
| Chen, NN; Liu, B; Liu, D; Liu, GP; Luo, DJ; Ni, ZF; Wang, JZ; Wang, Q; Wang, X; Yao, XQ; Yin, YY; Zhang, XX | 1 |
| Kanno, T; Nishizaki, T; Tsuchiya, A | 1 |
| An, FM; Chen, S; Gao, XD; Liu, AR; Yao, WB; Yin, DK; Yin, L | 1 |
| Liu, ZX; Luo, WW; Ma, D; Ma, SM; Su, Q; Sun, Y; Wang, CY; Wen, JK; Yang, YZ; Yang, Z; Zhang, XH; Zheng, B | 1 |
81 other study(ies) available for serine and wortmannin
| Article | Year |
|---|---|
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1997 |
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
Topics: Amino Acid Sequence; Androstadienes; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 7; Cloning, Molecular; DNA, Complementary; Enzyme Inhibitors; Flavonoids; GRB10 Adaptor Protein; Humans; Insulin; Molecular Sequence Data; Phosphorylation; Protein Binding; Proteins; Receptor, Insulin; Sequence Homology, Amino Acid; Serine; Signal Transduction; src Homology Domains; Wortmannin | 1997 |
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.
Topics: Androstadienes; Binding Sites; Cell Nucleus; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Gene Products, tat; HeLa Cells; HIV Long Terminal Repeat; HIV-1; Humans; Jurkat Cells; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Sp1 Transcription Factor; tat Gene Products, Human Immunodeficiency Virus; Transcription, Genetic; Wortmannin | 1998 |
FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Adhesion Molecules; DNA Fragmentation; Down-Regulation; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Hydrogen Peroxide; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Serine; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1999 |
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.
Topics: Amino Acid Substitution; Androstadienes; Animals; Blood Proteins; Cell Cycle Proteins; Cells, Cultured; Consensus Sequence; Enzyme Inhibitors; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Insulin; Liver; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Simian virus 40; Structure-Activity Relationship; Threonine; Transcription Factors; Wortmannin | 1999 |
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Androstadienes; Antibody Specificity; bcl-Associated Death Protein; Caenorhabditis elegans Proteins; Carrier Proteins; Consensus Sequence; DNA-Binding Proteins; Enzyme Activation; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Sirolimus; Threonine; Transcription Factors; Wortmannin | 1999 |
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase.
Topics: Androstadienes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Cell Membrane; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Green Fluorescent Proteins; Humans; Insulin; Luminescent Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Serine; Wortmannin; Xenopus | 1999 |
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.
Topics: Androstadienes; Animals; Binding Sites; Cell Line; COS Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Swine; Wortmannin | 1999 |
Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal.
Topics: Androstadienes; Apoptosis; Cell Line; DNA Replication; Enzyme Inhibitors; Interleukin-3; Isoenzymes; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Transfection; Wortmannin | 1999 |
Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress.
Topics: Amino Acid Sequence; Androstadienes; Animals; Calcium; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Stress, Mechanical; Swine; Wortmannin | 2000 |
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.
Topics: Amino Acid Sequence; Androstadienes; Animals; Humans; Immunization; Jurkat Cells; Molecular Sequence Data; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Serine; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2000 |
A DNA damage signal is required for p53 to activate gadd45.
Topics: Acetylation; Androstadienes; Camptothecin; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deoxyribonuclease I; DNA; DNA Damage; GADD45 Proteins; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53; Wortmannin | 2000 |
Hepatocyte growth factor-induced differential activation of phospholipase cgamma 1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes.
Topics: Actins; Androstadienes; Animals; Astrocytes; Blotting, Western; Cell Movement; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Genes, Dominant; Hepatocyte Growth Factor; Intracellular Signaling Peptides and Proteins; Isoenzymes; Microscopy, Fluorescence; Mutation; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Pyrrolidinones; Rats; Rats, Wistar; Recombinant Proteins; Serine; Signal Transduction; Time Factors; Transfection; Type C Phospholipases; Vanadates; Wortmannin | 2000 |
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.
Topics: Androstadienes; Blotting, Southern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dimerization; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Esophageal Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Ligands; Morpholines; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin | 2000 |
Wortmannin and LY294002 inhibit myo-inositol accumulation by cultured bovine aorta endothelial cells and murine 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Carrier Proteins; Cattle; Cells, Cultured; Choline; Chromones; Endothelium, Vascular; Heat-Shock Proteins; Inositol; Membrane Proteins; Mice; Morpholines; Osmolar Concentration; Phosphatidylinositol 3-Kinases; RNA, Messenger; Serine; Symporters; Time Factors; Wortmannin | 2000 |
Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin.
Topics: Adenocarcinoma, Papillary; Androstadienes; Antineoplastic Agents; bcl-Associated Death Protein; Carrier Proteins; Cisplatin; Enzyme Activation; Enzyme Inhibitors; Female; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Tumor Cells, Cultured; Wortmannin | 2000 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
Topics: Adenoviridae; Androstadienes; Animals; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Threonine; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2001 |
Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells.
Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cadmium Chloride; Caffeine; Cell Cycle Proteins; DNA-Activated Protein Kinase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2001 |
Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus.
Topics: Androstadienes; Animals; Apoptosis; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors; Gerbillinae; Hippocampus; Immunohistochemistry; Ischemic Preconditioning; Male; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Wortmannin | 2001 |
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation.
Topics: Adjuvants, Immunologic; Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Chromones; COS Cells; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Immunoblotting; Lithium Chloride; Morpholines; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Threonine; Time Factors; Transfection; Umbilical Veins; Wortmannin | 2002 |
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Binding Sites; Cell Line; COS Cells; Feedback; Humans; Mice; Mitosis; Models, Biological; Mutagenesis, Site-Directed; Neuregulin-1; Oncogene Proteins v-erbB; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Transfection; Wortmannin | 2002 |
Contraction regulation of Akt in rat skeletal muscle.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Morpholines; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Serine; Signal Transduction; Threonine; Time Factors; Tyrosine; Wortmannin | 2002 |
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
Topics: Acetylation; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Imidazoles; Phosphorylation; Protein Serine-Threonine Kinases; Radiation, Ionizing; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2002 |
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Binding Sites; Cell Line; Enzyme Inhibitors; Genes, Dominant; Glutathione Transferase; Humans; Immunoblotting; Insulin; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transfection; Wortmannin | 2002 |
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Topics: Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Survival; DNA-Activated Protein Kinase; DNA-Binding Proteins; G1 Phase; HeLa Cells; Humans; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Radiation Tolerance; S Phase; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2002 |
Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Androstadienes; Animals; Calcium; Calcium-Binding Proteins; Cell Size; Cells, Cultured; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ethanolamines; GTP-Binding Protein alpha Subunits, Gs; Heart Ventricles; Heterotrimeric GTP-Binding Proteins; Imidazoles; Insulin-Like Growth Factor I; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Receptors, Adrenergic, beta-2; Serine; Signal Transduction; Wortmannin | 2002 |
Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase.
Topics: Androstadienes; Animals; Aorta; Cattle; CD8 Antigens; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Immunoblotting; Mutation; Myristic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Palmitic Acid; Phenotype; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Signal Transduction; Time Factors; Transfection; Wortmannin | 2002 |
Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.
Topics: Androstadienes; Cell Line; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Humans; Indoles; Maleimides; Mesylates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Serine; Signal Transduction; Wortmannin | 2003 |
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Estradiol rapidly activates Akt via the ErbB2 signaling pathway.
Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Fulvestrant; Genistein; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Serine; Signal Transduction; Sirolimus; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 2003 |
Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms.
Topics: Androstadienes; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Survival; Cells, Cultured; Chromones; Hematopoietic Stem Cells; Insulin-Like Growth Factor I; Interleukin-3; Interleukin-4; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Sirolimus; Wortmannin | 2003 |
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Androstadienes; Anisomycin; Binding Sites; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Genes, Dominant; Glutathione Transferase; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; Repressor Proteins; Sequence Homology, Amino Acid; Serine; Time Factors; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Tyrosine 3-Monooxygenase; Wortmannin | 2003 |
Serine 338 phosphorylation is dispensable for activation of c-Raf1.
Topics: Androstadienes; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Glutathione Transferase; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; Signal Transduction; Time Factors; Tyrosine; U937 Cells; Wortmannin | 2003 |
Reconstitution of phosphoinositide 3-kinase-dependent insulin signaling in a cell-free system.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Cell Membrane; Cell-Free System; Cytosol; Glutathione Transferase; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Recombinant Fusion Proteins; Serine; Signal Transduction; Subcellular Fractions; Threonine; Time Factors; Wortmannin | 2003 |
Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Antineoplastic Agents; Cells, Cultured; Humans; Immunosuppressive Agents; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Proline; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Sirolimus; Threonine; Transfection; Wortmannin | 2003 |
Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Androstadienes; Animals; Apoptosis; Blotting, Northern; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cloning, Molecular; COS Cells; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Glutathione Transferase; Humans; Immunoblotting; In Situ Nick-End Labeling; Ki-1 Antigen; Lymphoma, Large B-Cell, Diffuse; Mice; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoamino Acids; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Tissue Distribution; Transfection; Two-Hybrid System Techniques; Type C Phospholipases; Tyrosine; Wortmannin | 2003 |
Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin.
Topics: Androstadienes; Apoptosis; Blotting, Northern; Cell Division; Chromones; Cytokines; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Dominant; Humans; Inflammation; Interferon-gamma; Lipopolysaccharides; Models, Biological; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Protein Kinases; RNA, Small Interfering; Serine; STAT1 Transcription Factor; TOR Serine-Threonine Kinases; Trans-Activators; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Wortmannin | 2003 |
Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.
Topics: Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; Binding Sites; Blotting, Western; Cell Line; Cycloheximide; DNA, Complementary; Enzyme Inhibitors; Glioma; Glutathione Transferase; Humans; Intracellular Signaling Peptides and Proteins; Mutation; Peptides; Phosphoproteins; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2003 |
A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Glucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Male; Morpholines; Muscle Contraction; Muscle, Skeletal; Organometallic Compounds; Phenanthrolines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Physical Exertion; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Tyrosine; Vanadates; Wortmannin | 2003 |
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.
Topics: Adenocarcinoma; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Hydrogen Peroxide; Hyperoxia; Kidney; Lung Neoplasms; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Oxidants; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Serine; Tumor Suppressor Protein p53; Ultraviolet Rays; Wortmannin | 2004 |
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.
Topics: Amino Acid Sequence; Amino Acids; Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Line; CHO Cells; Cricetinae; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphoproteins; Phosphorylation; Point Mutation; Precipitin Tests; Rats; Serine; Signal Transduction; Sirolimus; Time Factors; Wortmannin | 2004 |
Mechanisms of shear stress-induced endothelial nitric-oxide synthase phosphorylation and expression in ovine fetoplacental artery endothelial cells.
Topics: Androstadienes; Animals; Butadienes; Calcium; Chelating Agents; Endothelium, Vascular; Enzyme Inhibitors; Female; Fibroblast Growth Factor 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Placental Circulation; Pregnancy; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulsatile Flow; Serine; Sheep; Signal Transduction; Stress, Mechanical; Vascular Endothelial Growth Factor A; Wortmannin | 2004 |
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.
Topics: Androstadienes; Animals; Antibodies, Monoclonal; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Escape Reaction; Glycogen Synthase Kinase 3; Hippocampus; Immunohistochemistry; Indoles; Injections, Intraventricular; Male; Maleimides; Maze Learning; Memory Disorders; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Serine; tau Proteins; Wortmannin | 2003 |
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation.
Topics: Androstadienes; Brain Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Fractionation; Cell Line; Cell Membrane; Cell Nucleus; Cytochromes c; Cytosol; Drug Interactions; Electron Transport Complex IV; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoblotting; Insulin-Like Growth Factor I; Ionophores; Kidney; Mitochondria; Mitochondrial Proton-Translocating ATPases; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphorylation; Porins; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Threonine; Time Factors; Voltage-Dependent Anion Channel 1; Wortmannin | 2003 |
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.
Topics: Androstadienes; Animals; Chromones; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insulin Resistance; Leptin; Lipid Metabolism; Liver; Male; Morpholines; Obesity; Oxygen Consumption; Perfusion; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinolones; Rats; Rats, Wistar; Serine; Time Factors; Triglycerides; Wortmannin | 2004 |
Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.
Topics: Androstadienes; Angiotensin II; Animals; Aorta; Blotting, Western; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Mitogen-Activated Protein Kinases; Mitogens; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Rats; Retinoblastoma Protein; Serine; Serotonin; Time Factors; Wortmannin | 2004 |
PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Serine; Swiss 3T3 Cells; Tyrosine; Wortmannin | 2004 |
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
Topics: Amino Acid Sequence; Androstadienes; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Caffeine; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Chromatography, Gel; Chromones; DNA-Binding Proteins; DNA, Neoplasm; DNA, Single-Stranded; Enzyme Inhibitors; HeLa Cells; Heparin; Humans; Molecular Weight; Morpholines; Peptides; Phosphorylation; Poly Adenosine Diphosphate Ribose; Protein Kinases; Protein Serine-Threonine Kinases; Radiation, Ionizing; Serine; Tumor Suppressor Proteins; Wortmannin | 2004 |
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Topics: Acetylcysteine; Androstadienes; Antibiotics, Antineoplastic; Antineoplastic Agents; Ascorbic Acid; Ataxia Telangiectasia Mutated Proteins; Binding Sites; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Nucleus; DNA; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Histones; Humans; Hydroxyl Radical; Image Processing, Computer-Assisted; Immunoblotting; Immunoprecipitation; Microscopy, Fluorescence; Oligonucleotides; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Radiation, Ionizing; Reactive Oxygen Species; Serine; Signal Transduction; Threonine; Time Factors; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2004 |
In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Androstadienes; Animals; Antineoplastic Agents; beta-Cyclodextrins; Binding Sites; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Inositol Phosphates; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Mitochondria; Models, Chemical; Models, Molecular; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Time Factors; Wortmannin | 2004 |
Phosphorylation of grb10 regulates its interaction with 14-3-3.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Androstadienes; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Membrane; COS Cells; Cytosol; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glutathione Transferase; GRB10 Adaptor Protein; HeLa Cells; Humans; Immunoprecipitation; Models, Biological; Mutation; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Biosynthesis; Proteins; Serine; Signal Transduction; Time Factors; Two-Hybrid System Techniques; Wortmannin | 2005 |
Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells.
Topics: Androstadienes; Animals; Calcineurin; Calcium; Cell Line; Cell Line, Tumor; Cell Membrane; Enzyme Inhibitors; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunoblotting; Immunoprecipitation; Microscopy, Confocal; Naphthalenes; PC12 Cells; Phosphoprotein Phosphatases; Phosphorylation; Potassium Chloride; Rats; Serine; Threonine; Time Factors; Transfection; Wortmannin | 2005 |
Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons.
Topics: Alkaline Phosphatase; Analysis of Variance; Androstadienes; Anesthetics, Local; Animals; Animals, Newborn; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Cell Size; Cells, Cultured; Chromones; Connexins; Densitometry; Diagnostic Imaging; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Immunohistochemistry; Ion Channels; Lectins; Male; Morpholines; Myelin Sheath; Nerve Block; Nerve Tissue Proteins; Neurons; Phosphorylation; Potassium Chloride; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sciatic Nerve; Serine; Tetrodotoxin; Time Factors; TRPV Cation Channels; Tubulin; Wortmannin | 2005 |
Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase.
Topics: Active Transport, Cell Nucleus; Alternative Splicing; Androstadienes; Animals; beta Catenin; Blotting, Western; Cell Nucleus; Cyclin D1; Cytoplasm; Cytoskeletal Proteins; Enzyme Inhibitors; Gene Silencing; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Models, Biological; Neoplasms; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Receptor Protein-Tyrosine Kinases; RNA, Messenger; RNA, Small Interfering; Serine; Trans-Activators; Tyrosine; Wortmannin | 2005 |
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
Topics: Alleles; Androstadienes; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Inhibitors; Genetic Vectors; Humans; Immunoblotting; Immunoprecipitation; Insulin; Models, Biological; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; RNA, Small Interfering; Serine; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2005 |
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.
Topics: Androstadienes; Animals; Cyclic AMP; Drug Synergism; Epinephrine; Glycogen Phosphorylase; Guanine Nucleotide Exchange Factors; Insulin; Male; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Serine; Signal Transduction; Threonine; Wortmannin | 2005 |
Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.
Topics: Androstadienes; Animals; Anthracenes; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Densitometry; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Gene Transfer Techniques; Glutathione Transferase; Immunoassay; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Peptides; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Rats; Retroviridae; Serine; Signal Transduction; Sirolimus; Transfection; Tumor Necrosis Factor-alpha; Wortmannin | 2005 |
Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
Topics: Actins; Adaptor Protein Complex 2; Androstadienes; Arrestins; beta-Adrenergic Receptor Kinases; beta-Arrestins; Cell Line; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Histones; Humans; Models, Biological; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-2; RNA, Small Interfering; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection; Transferrin; Tropomyosin; Wortmannin | 2005 |
Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
Topics: Androstadienes; Animals; bcl-Associated Death Protein; Blotting, Western; Cell Count; Cell Proliferation; Chromones; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Gene Silencing; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Immunoprecipitation; Isoquinolines; Macrophages; Mice; Mice, Inbred C57BL; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; rap1 GTP-Binding Proteins; RNA Interference; RNA, Double-Stranded; Serine; Signal Transduction; Sulfonamides; Threonine; Thymidine; Time Factors; Up-Regulation; Wortmannin; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.
Topics: Adenocarcinoma; Alkaline Phosphatase; Androstadienes; beta Catenin; Butyrates; Cell Line, Tumor; Colorectal Neoplasms; Humans; Immunohistochemistry; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Tyrosine; Wortmannin | 2006 |
Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
Topics: Adipocytes; Androstadienes; Animals; Cells, Cultured; CHO Cells; Chromatography, Ion Exchange; Cricetinae; Electrophoresis, Polyacrylamide Gel; Epididymis; Extracellular Signal-Regulated MAP Kinases; GTPase-Activating Proteins; Humans; Immunoprecipitation; Insulin; Male; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Recombinant Proteins; rhoA GTP-Binding Protein; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Transfection; Tumor Suppressor Proteins; Wortmannin | 2006 |
Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.
Topics: Abnormalities, Multiple; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chloroquine; Chromatin; DNA Damage; DNA-Binding Proteins; Female; Humans; Male; Phosphorylation; Phosphotransferases; Protein Serine-Threonine Kinases; Radiation Tolerance; Radiation, Ionizing; Serine; Syndrome; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Wortmannin | 2006 |
Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs.
Topics: Androstadienes; Animals; Calcium; Cattle; Chromones; Endothelial Cells; Enzyme Activation; Large-Conductance Calcium-Activated Potassium Channels; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Shear Strength; Signal Transduction; Wortmannin | 2006 |
Serine 1179 phosphorylation of endothelial nitric oxide synthase caused by 2,4,6-trinitrotoluene through PI3K/Akt signaling in endothelial cells.
Topics: Androstadienes; Animals; Aorta; Cattle; Cells, Cultured; Chromones; Endothelial Cells; Environmental Pollutants; Morpholines; Nitric Oxide Synthase Type III; Occupational Exposure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Trinitrotoluene; Wortmannin | 2006 |
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.
Topics: Amino Acid Sequence; AMP-Activated Protein Kinases; Androstadienes; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Endothelium, Vascular; Estrenes; Humans; Isoquinolines; Multienzyme Complexes; Naphthalimides; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyrrolidinones; Serine; Type C Phospholipases; Vascular Endothelial Growth Factor A; Wortmannin | 2007 |
Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway.
Topics: Acetylcysteine; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Butadienes; Catalase; Cell Cycle Proteins; DNA Damage; DNA Fragmentation; DNA-Binding Proteins; Epithelial Cells; Humans; Lung; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Vanadates; Wortmannin | 2007 |
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line, Tumor; Immunohistochemistry; Immunoprecipitation; Mutation; Neurofibromin 2; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Serine; Threonine; Ubiquitins; Wortmannin | 2007 |
EHDS are serine phosphoproteins: EHD1 phosphorylation is enhanced by serum stimulation.
Topics: Androstadienes; Animals; Caveolins; Cell Line; Clathrin; Endocytosis; Humans; Nocodazole; Phosphoproteins; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase Inhibitors; Serine; Serum; Tubulin Modulators; Vesicular Transport Proteins; Wortmannin | 2008 |
Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade.
Topics: Analysis of Variance; Androstadienes; Animals; bcl-Associated Death Protein; Cell Death; Chromones; Dizocilpine Maleate; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Intraocular Pressure; Ischemia; Male; Morpholines; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retinal Diseases; Serine; Signal Transduction; Time Factors; Wortmannin | 2008 |
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin | 2009 |
Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.
Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Androstadienes; Animals; Electric Stimulation; Electroporation; Female; Gene Transfer Techniques; Glucose; GTPase-Activating Proteins; Humans; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Muscle Contraction; Muscle, Skeletal; Mutation; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quadriceps Muscle; Recombinant Proteins; Ribonucleotides; Serine; Sirolimus; Tandem Mass Spectrometry; Time Factors; Wortmannin; Young Adult | 2010 |
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Mice; Muscle, Skeletal; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Serine; Sirolimus; Threonine; Transcription Factors; Wortmannin | 2010 |
PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.
Topics: 14-3-3 Proteins; Androstadienes; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Enzyme Inhibitors; Glioma; Humans; Immunoprecipitation; Isoenzymes; Models, Biological; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Kinase C; Protein Multimerization; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA Interference; Serine; Signal Transduction; Wortmannin | 2011 |
Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation.
Topics: Androstadienes; Animals; Anticoagulants; Bromodeoxyuridine; Cell Proliferation; Chlorofluorocarbons, Methane; Chromones; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Granulins; Heparin; Hippocampus; Intercellular Signaling Peptides and Proteins; Intermediate Filament Proteins; Mice; Mice, Knockout; Morpholines; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Phosphorylation; Progranulins; Serine; Tubulin; Wortmannin | 2011 |
Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.
Topics: Androstadienes; Animals; Cyclic AMP Response Element-Binding Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Indoles; Maleimides; Mice; Mice, Inbred C57BL; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; RNA, Messenger; Serine; src-Family Kinases; tau Proteins; Transcription, Genetic; Tyrosine; Wortmannin | 2011 |
PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
Topics: 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; Glucose; Glucose Transporter Type 4; Heterocyclic Compounds, 3-Ring; Hypoglycemic Agents; Insulin; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA Interference; Serine; Signal Transduction; Threonine; Wortmannin | 2014 |
Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation.
Topics: Androstadienes; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glucagon-Like Peptide 1; Glucose; Glycation End Products, Advanced; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Neurons; Neuroprotective Agents; Phosphorylation; Rats; Rats, Wistar; Serine; Serum Albumin, Bovine; tau Proteins; Wortmannin | 2014 |
Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467.
Topics: Androstadienes; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Flavonoids; HEK293 Cells; Humans; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Serine; Signal Transduction; Wortmannin | 2018 |