serine has been researched along with tyrosine in 1368 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 426 (31.14) | 18.7374 |
| 1990's | 215 (15.72) | 18.2507 |
| 2000's | 465 (33.99) | 29.6817 |
| 2010's | 201 (14.69) | 24.3611 |
| 2020's | 61 (4.46) | 2.80 |
| Authors | Studies |
|---|---|
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Bonini, BM; Thevelein, JM; Van Zeebroeck, G; Versele, M | 1 |
| Krauss, G; Maass, G; Riesner, D | 1 |
| Drapeau, GR; Dugas, H; Finkenstadt, WR; Leduc, P; Markley, JL | 1 |
| Hirayama, O; Maenaka, K; Matsuda, H; Takatsuka, H; Takeda, H | 1 |
| Glimcher, MJ | 1 |
| Singh, A | 1 |
| Ashman, PU; Newport, GR; Page, CR; Seed, JR; Stibbs, HH | 1 |
| Csonka, LN | 1 |
| Krauss, G; Maass, G; Peters, F; Pingoud, A; Urbanke, C | 1 |
| Umbarger, HE | 2 |
| Ono, BI; Sherman, F; Stewart, JW | 1 |
| Bodanszky, M; Martinez, J; Tolle, JC | 1 |
| Byram, JE; Senft, AW | 1 |
| Bertolini, AM; Santagostino, A | 1 |
| Biondi, A; Biondi, G; Gallone, U; Padula, P; Pignero, A; Quagliuolo, L | 1 |
| Cavadore, JC; Coletti-Previero, MA; Previero, A; Torreilles, J | 1 |
| Bantzer, P; Jäkel, A; Liappis, N | 1 |
| Davidson, CS; Fernstrom, JD; Hammarstrom-Wiklund, B; Munro, HN; Rand, WM; Wurtman, RJ | 2 |
| Bacciarelli, C; Bonacchi, G; Boni, P; Castellucci, A | 1 |
| Bailey, RS; Fried, B | 1 |
| Jontofsohn, R; Katz, N; Kluthe, R; Trivisas, G | 1 |
| Chou, HJ; Gregerman, RI; Rehfield, PL | 1 |
| Bayley, HS; Chavez, ER | 1 |
| Conte, FP | 1 |
| Harada, K; Iwaki, T; Koyama, Y; Oyama, S; Uchida, H | 1 |
| Bodanszky, M; Gardner, JD; Hahne, W; Natarajan, S | 1 |
| Ikeda, Y; Inagaki, C; Ishikawa, M; Tanaka, C; Yamazaki, M | 1 |
| Barbeau, A; Beroniade, V; Breton, G; Geoffroy, G; Lemieux, B; Melançon, S; Shapcott, D | 1 |
| Counahan, R; Cox, BD; El-Bishti, M; Ogg, CS | 1 |
| Kiseleva, AG; Pankov, IuA | 1 |
| Lowe, NR; Robinson, C; Weatherell, JA | 1 |
| Rytka, J | 1 |
| Nathanson, NM; Schleif, R | 1 |
| Boehme, D; Krauss, G; Maas, G; Peters, F; Pingoud, A; Riesner, D | 1 |
| Heathcote, JG; Keogh, BJ; Washington, RJ | 1 |
| Bayer, E; Hemmasi, B | 1 |
| Chellemi, F | 1 |
| Bell, JR; Jones, JH; Webb, TC | 1 |
| Kalinovskiĭ, VP; Parshin, AN | 1 |
| Kumagai, H; Yamada, H | 1 |
| Erfle, JD; Mahadevan, S; Sauer, FD | 1 |
| Guadalix, FJ; Ruiz, MC | 1 |
| Biguet, J; Dujardin, L; Lacoste, L | 1 |
| Heinrich, D; Kubli, F; Metz, J; Wesch, H | 1 |
| Goodfellow, JM; Morris, AS; Thanki, N | 1 |
| Countaway, JL; Davis, RJ; Nairn, AC | 1 |
| Barrett, CB; Erikson, E; Maller, JL | 1 |
| Heidecker, G; Kölch, W; Morrison, DK; Rapp, UR | 1 |
| Ishida, Y; Kawahara, Y; Koide, M; Tsuda, T; Yokoyama, M | 1 |
| Carpenter, G; Jones, G | 1 |
| Davis, RJ; Latour, DA; Raden, DL; Stanley, K; Theroux, SJ | 1 |
| Charbonneau, H; Cool, DE; Fischer, EH; Tonks, NK | 1 |
| Hunter, T; Lindberg, RA; Quinn, AM | 1 |
| Abeles, RH; Epstein, DM | 1 |
| Hunter, T; Meisenhelder, J | 1 |
| Hirayama, T; Oka, A | 1 |
| Cooper, JA; Posada, J | 1 |
| Marin, O; Meggio, F; Perich, JW; Pinna, LA | 1 |
| Asplund, T; Heldin, P; Laurent, TC; Thelin, S; Ytterberg, D | 1 |
| Chan, T; Lee, M; Sakmar, TP | 1 |
| Bordin, L; Clari, G; Moret, V | 1 |
| Avruch, J; Brautigan, DL; Ingebritsen, TS; Kyriakis, JM | 1 |
| Mendelsohn, J; Peacock, JS; Sunada, H; Yu, P | 1 |
| Anderson, SR; Malencik, DA; Zhao, ZZ | 1 |
| Iwashita, S; Mitsui, K | 1 |
| Kim, HK; Kim, JG; Kim, JW; Margolis, B; Rhee, SG; Schlessinger, J; Zilberstein, A | 1 |
| Kanner, SB; Parsons, JT; Reynolds, AB; Vines, RR; Wang, HC | 1 |
| Klee, U; Singh, TJ | 1 |
| Breckenridge, MB; Grants, IS; Liu, BQ; Newhouse, YG; Walters, JD; Whisler, RL | 1 |
| Park, DJ; Rhee, SG; Rho, HW | 1 |
| Dickens, M; Tavaré, JM | 1 |
| Brautigan, DL; Clark, EA; Gallis, B; Ledbetter, JA; Pinault, F; Valentine, MA; Voice, R; Widmer, MB | 1 |
| Alengrin, F; Ballotti, R; Dull, T; Lammers, R; Schlessinger, J; Tartare, S; Ullrich, A; Van Obberghen, E | 1 |
| Benkovic, SJ; Carroll, SS; Cowart, M | 1 |
| Beidler, DR; Stern, DF; Zerillo, C; Zheng, P | 1 |
| Arzt, J; Ferrone, C; McGraw, TE; Pytowski, B | 1 |
| Kanner, SB; Parsons, JT; Reynolds, AB; Vines, RR; Wu, H | 1 |
| McNamee, H; Paul, DL; Piwnica-Worms, H; Swenson, KI | 1 |
| Hamano, S; Morita, K; Oka, M; Teraoka, K | 1 |
| Houghten, RA; Ruggeri, ZM; Vicente, V | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Clari, G; Marzaro, G; Moret, V | 1 |
| Bussolino, F; Comoglio, PM; Di Renzo, MF; Gandino, L; Giordano, S | 1 |
| Goodfellow, JM; Thanki, N; Thornton, JM | 1 |
| Hitoshi, Y; Murata, Y; Takatsu, K; Tominaga, A; Yamaguchi, N | 1 |
| Chinami, M; Goto, M; Ohtsu, Y; Shingu, M; Yuge, K | 1 |
| Aitken, A; Morrice, N | 1 |
| Benjamin, TL; Matthews, JT | 1 |
| Blumenthal, DK; Chan, CP; Gallis, B; Krebs, EG; Pallen, CJ; Wang, JH | 1 |
| Etheredge, RW; Glimcher, MJ | 1 |
| Bauer, H; Niemann, H; Simon, E; Snoek, GT; Tamura, T | 1 |
| Gordon, JA; Ryder, JW | 1 |
| David-Pfeuty, T; Guesdon, F | 1 |
| Colca, JR; McCroskey, MC; Pearson, JD | 1 |
| Sale, GJ; Smith, DM | 1 |
| Beachey, EH; Kotb, M | 1 |
| Boland, D; Goren, HJ; Neufeld, E | 1 |
| Gjika, HB; Levine, L; Van Vunakis, H | 1 |
| Lane, AN | 1 |
| Adlakha, RC; Kuang, J; Rao, PN; Zhao, JY | 1 |
| Pessin, JE; Treadway, JL; Whittaker, J | 1 |
| Beale, D; Coadwell, J | 1 |
| Beachey, EH; Courtney, HS; Dale, JB; Kotb, M | 1 |
| Capeau, J; Capony, JP; Caron, M; Grigorescu, F; Magré, J; Mirouze, J; Picard, J; Reynet, C; White, MF | 1 |
| Bar-Zvi, D; Branton, D; Erikson, RL; Martin-Perez, J | 1 |
| Benson, MD; Wallace, MR | 1 |
| Cobb, MH; Ellis, L; Levitan, A; Ramos, P | 1 |
| Askanazi, J; Elwyn, DH; Gil, KM; Gump, FE; Kinney, JM; Starker, PM | 1 |
| Lu, PW; Tao, M | 1 |
| Hunter, T; Isacke, CM; Trowbridge, IS | 1 |
| Cooper, JA; Hunter, T | 1 |
| Cantin, M; Chrétien, M; De Léan, A; Genest, J; Gutkowska, J; Lazure, C; Seidah, NG; Thibault, G | 1 |
| Corvera, S; Czech, MP; Davis, RJ; Lewis, RE; MacDonald, RG; Mottola, C; Necessary, PC; Yu, KT | 1 |
| Hoffman, BM; Liang, N; Mauk, AG; Pielak, GJ; Smith, M | 1 |
| Dixon, D; Ellis, L; Jong, SM; Lin, B; Roth, RA; Rutter, WJ; Wang, LH | 1 |
| Herrera, R; Rosen, OM | 1 |
| de Boer, JE; Janssen, MA; Oostenbroek, RJ; Soeters, PB; van Dongen, JJ | 1 |
| Hoffbrand, AV; Mire, AR; Wickremasinghe, RG | 1 |
| Henschen, A; Lucas, J | 1 |
| Kuyl-Yeheskiely, E; Schaeffer, AH; Tromp, CM; van Boom, JH; van der Marel, GA | 1 |
| Hachiya, HL; King, GL; Takayama, S; White, MF | 1 |
| Fox, CF; Rao, KV | 1 |
| McCarley, DJ; Parsons, SJ | 1 |
| Gibson, CJ | 1 |
| Kahn, CR; Takayama, S; White, MF | 1 |
| Cheng, N; Sahyoun, N | 1 |
| Gerber, GE; Morton, RC | 1 |
| Martin, GS; Schieven, G | 1 |
| Baniyash, M; Garcia-Morales, P; Klausner, RD; Luong, E; Samelson, LE | 1 |
| Aaviksaar, A; Osa, A; Sikk, P | 1 |
| Reches, A | 1 |
| Kolchanov, NA; Shindyalov, IN | 1 |
| Jöchle, W; Stöckl, W | 1 |
| Kelly, B; Levy, JG | 1 |
| Friedenson, B; Pressman, D; Roholt, OA; Takeda, Y | 1 |
| Bryce, GF | 1 |
| Hardy, MJ | 1 |
| Kasarian, BA | 1 |
| Jaton, JC | 1 |
| Hess, M; Hilschmann, N; Ponstingl, H | 1 |
| Bundgaard, L; Winther, A | 1 |
| Banerjee, AB; Bhattacharyya, SK | 1 |
| Braun, W; Weiss, C; Zschaler, W | 1 |
| Carlsson, A; Lindqvist, M | 1 |
| Dziewiatkowski, DD; Hascall, VC; Riolo, RL | 1 |
| Donnell, GN; Koch, R; Lieberman, E; Shaw, KN | 1 |
| Axelrod, VD; Bayev, AA; Chuguev, II | 1 |
| Froncish, W; Kalmanson, AE; Kharitonenkov, IG; Yuferov, VP | 1 |
| Erikson, E; Erikson, RL | 1 |
| Choe, BK; Taylor, MW; Volkers, SA; Zeikus, JG | 1 |
| Karadźić, V; Micić, D; Rakić, L | 1 |
| Taylor, MW; Volkers, SA | 1 |
| Philippsen, P; Zachau, G | 1 |
| Philippsen, P; Zachau, HG | 1 |
| Lowry, PJ; McMartin, C | 1 |
| Sherman, F; Stewart, JW | 1 |
| Kaback, HR; Lombardi, FJ; Reeves, JP; Short, SA | 1 |
| Crippa, PR; Tedeschi, RA; Vecli, A | 1 |
| Casey, JW; Getz, GS; Hsu, HJ; Rabinowitz, M | 1 |
| Milholland, RJ; Rosen, F | 1 |
| Kuhn, J; Somerville, RL | 1 |
| Aktin, E; Bergisadi, N; Güven, KC; Koyuncuoglu, H | 1 |
| Dallaire, L; Melancon, SB; Patrick, J; Potier, M | 1 |
| Filner, B; Marcus, A | 1 |
| Allsopp, MN; Hullin, RP; Rees, JR | 1 |
| Asafov, GB; Ekisenina, NI; Ivanova, LM; Lumel'skiĭ, VIa; Smagin, VG | 1 |
| Jäkel, A; Liappis, N | 1 |
| Ambani, LM; Liu, YP; Van Woert, MH | 1 |
| Crossley, AC; Evans, PD | 1 |
| el-Sewefy, AZ; Hegazi, SM | 1 |
| Anandaraj, MP; Cherayil, JD | 1 |
| Arrio, B; Foucault, G; Kellershohn, N; Parquet, C; Seydoux, F; Yon, J | 1 |
| Awad, WM; Ochoa, MS; Toomey, TP | 1 |
| Cramer, F; Engel, G; Heider, H; Maelicke, A; von der Haar, F | 1 |
| Schneider, D; Solfert, R; von der Haar, F | 1 |
| Hofmann, T; Kurosky, A | 1 |
| Kaplan, S | 1 |
| Nair, RM; Schally, AV | 1 |
| Hearn, RA; Lacey, JC; Mullins, DW | 1 |
| Sunde, ML | 1 |
| Presthus, J | 1 |
| Cary, L; Kearns, DR; Lightfoot, DR; Reid, BR; Shulman, RG; Wong, KL; Wong, YP | 1 |
| Cramer, F; Maelicke, A; Prinz, H | 1 |
| Bhattacharya, RK | 1 |
| Doctor, BP; Sodd, MA | 1 |
| Staehelin, M | 2 |
| Halpern, YS | 1 |
| Pittsyn, OB | 1 |
| First, RG; Kew, MC | 1 |
| Mavrides, C | 1 |
| Maurer, W; Rabbani, B; Schultze, B | 1 |
| Ali, A; Faesel, JH; Sarantakis, D; Stevenson, D; Weinstein, B | 1 |
| Araya, A; Goodman, M; Maita, T; Matsuda, G; Ota, H; Prychodko, W; Watanabe, B | 1 |
| Alimov, IIu; Iur'eva, EA; Marchenko, ZM | 1 |
| Matsuka, GKh; Poliakova, LL; Skvirskaia, EB; Sukhinin, VN | 1 |
| Matsuka, GKh; Oleinik, TL; Poliakova, LL; Skvirskaia, EB | 1 |
| Gruen, LC | 1 |
| Gruber, L; Harris, JE | 1 |
| Paolucci, AM; Pennetti, V; Spadoni, MA | 1 |
| Adibi, SA; Amin, PM; Modesto, TA; Morse, EL | 1 |
| Frenkel, MJ; Gillespie, JM; Woods, EF | 1 |
| Lowenstein, LM; Mayers, AM; Toback, FG | 1 |
| Mani, NV; Morimoto, CN; Tulinsky, A; Vandlen, RL; Wright, LH | 1 |
| Tulinsky, A; Vandlen, RL | 1 |
| Jakubowski, H; Pawelkiewicz, J | 1 |
| Trayhurn, P; van Heyningen, R | 1 |
| Fox, M; Roberts, E; Wein, J; Weinstein, C | 1 |
| Daillie, J; Fournier, A; Garel, JP | 1 |
| Fridkin, M; Goren, HJ | 1 |
| Giorgio, AJ; Linarelli, LG; Macdonald, RR; Rubin, HM | 1 |
| Bergström, J; Fürst, P; Norée, LO; Vinnars, E | 1 |
| Combarnous, Y; Maghuin-Rogister, G | 1 |
| Kurylo-Borowska, Z; Sedkowska, J | 1 |
| Filippovich, IuB; Klunova, SM; Zhukova, NI | 1 |
| Kalnitsky, G; Spadari, S; Subramanian, AR | 1 |
| Huang, HT | 1 |
| Sloane, NH; Smith, SC | 1 |
| Kaji, A; Suzuka, I; Takeda, Y | 1 |
| Roy, KL; Söll, D | 1 |
| Ishikura, H | 1 |
| Sakiyama, F | 1 |
| Oxender, DL; Piperno, JR | 1 |
| Buck, CA; Granger, GA; Holland, JJ; Taylor, MW | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Berger, H; Yanofsky, C | 1 |
| Glimcher, MJ; Seyer, J | 1 |
| Derr, RF; Scanlon, KS | 1 |
| Riordan, JF; Vallee, BL | 1 |
| Sekiya, T; Ukita, T | 1 |
| Kumagai, H; Matsui, H; Ogata, K; Ohkishi, H; Yamada, H | 1 |
| Christomanos, AA; Dimitriades, A | 1 |
| Jörnvall, H | 1 |
| Bock, RM; Hecht, SM; Kirkegaard, LH | 1 |
| Dunlap, BE; Friderici, KH; Rottman, F | 1 |
| Staehelin, M; Wehrli, W | 1 |
| Arimura, A; Baba, Y; Matsuo, H; Nair, RM; Schally, AV | 1 |
| Abita, JP; Ailhaud, G; Lazdunski, M | 1 |
| Hunt, DE | 2 |
| Chamove, AS; Harlow, HF; Kerr, GR; Waisman, HA | 1 |
| Kerr, GR | 1 |
| Dolif, D; Jürgens, P | 1 |
| Kojima, H; Sugae, K | 1 |
| Morihara, K; Tsuzuki, H | 1 |
| Jesensky, C; Peterkofsky, A | 1 |
| Beuvery, EC; Dijk, J; Gruber, M; Konings, WN; Wichertjes, T | 1 |
| Clinton, GM; Spizizen, J; Vold, BS | 1 |
| Goldman, M; Griffin, AC | 1 |
| Cahill, CF; Felig, P; Marliss, E; Ohman, JL | 1 |
| Bourrillon, R; Jouanneau, J; Razafimahaleo, E | 1 |
| Enei, H; Matsui, H; Okumura, S; Yamada, H | 1 |
| Brunner, R; Reisner, W | 1 |
| Lee, DJ | 1 |
| Gajda, L; Grabowska, M; Maj, J | 1 |
| Dhatt, PS; Gupta, HL | 1 |
| Peterson, NA; Raghupathy, E | 1 |
| Alden, RA; Kraut, J; Wright, CS | 1 |
| Bergman, EN; Williams, HH; Wolff, JE | 1 |
| Charles, M; Desnuelle, P; Maylié, MF | 1 |
| Nelson, T; Sagerson, RN; Scott, CR; Teng, CC | 1 |
| Boling, JA; Bradley, NW; Willard, JC | 1 |
| Nagchaudhuri, J; Ozalp, I; Scrimshaw, NS; Tontisirin, K; Young, VR | 1 |
| Barry, LG; Coletti-Previero, MA; Previero, A | 1 |
| Fujioka, S; Gallo, RC | 1 |
| Morishita, S; Muramatsu, K; Odagiri, H; Takeuchi, H | 1 |
| Ono, T; Tasaki, I | 1 |
| Craft, IL; Peters, TJ | 1 |
| Campbell, DJ; Reid, DW; Yakymyshyn, LY | 1 |
| Fairwell, T; Lovins, RE | 1 |
| Fernstrom, JD; Larin, F; Wurtman, RJ | 1 |
| Barkin, E; Levy, HL | 1 |
| Shearer, TR; Suttie, JW | 1 |
| Hornig, D; Weber, F; Wiss, O | 1 |
| Berger, RL; Lam, DP; Marini, MA; Martin, CJ | 1 |
| Ortwerth, BJ | 1 |
| Morihara, K; Oka, T; Tsuzuki, H | 1 |
| Kearney, EB; Seng, R; Singer, TP; Walker, WH | 1 |
| Kingham, B; Riley, SP; Robson, A | 1 |
| Mushinski, JF | 1 |
| Gold, MB; Reynold, JM; Scriver, CR | 1 |
| Kotelchuck, D; Scheraga, HA | 1 |
| Tews, JK | 1 |
| Hellman, A; Hellman, KB; Martin, DH; Novelli, GD; Yang, WK | 1 |
| Gallo, RC; Pestka, S | 1 |
| Geisler, C; Höcker, P; Stacher, A; Wiser, M | 1 |
| Barnard, EA; Kawiak, J; Komender, J; Vensel, WH | 1 |
| Menninger, JR | 1 |
| Appella, E; Martin, RG; Voll, MJ | 1 |
| Easley, CW; Kitchen, H | 1 |
| Kapoor, IJ; Tandon, RN | 1 |
| Vining, LC; Westlake, DW | 1 |
| Slifkin, MA; Walmsley, RH | 1 |
| Hoshino, S; Tsubota, H | 1 |
| Ermol'eva, ZV; Pokidova, NV; Zhuravleva, TP | 1 |
| Hatano, M; Obara, Y; Ono, S | 1 |
| Emanuel, CF; Hollahan, JR | 1 |
| de Groot, N; Lapidot, Y; Rubinstein, M | 1 |
| Arroyave, G | 1 |
| Blackburn, MN; Chatterjee, GC; Noltmann, EA; Pon, NG; Schnackerz, KD | 1 |
| Lohrenz, FN; Tewksbury, DA | 1 |
| Grimble, RF; Whitehead, RG | 1 |
| Hammar, UB; Strecker, HJ; Volpe, P | 1 |
| Houston, LL; Walsh, KA | 1 |
| Ashman, S; Bjorksten, J | 1 |
| Baguley, BC; Staehelin, M; Wehrli, W | 1 |
| Neuhoff, V; Weise, M | 1 |
| Svensson, TH | 1 |
| Blow, DM; Steitz, TA | 1 |
| McKean, CM; Peterson, NA | 1 |
| Melcher, G | 1 |
| King, L; Perham, RN | 1 |
| Balasubramanian, M; Myers, RF | 1 |
| Kerly, M; Spruyt, JE | 1 |
| Baños, G; Daniel, PM; Love, ER; Moorhouse, SR; Pratt, OE | 1 |
| Veis, A; Volpin, D | 1 |
| Flory, B; Krassner, SM | 1 |
| Debusk, AG; Wolfinbarger, L | 1 |
| Johnson, P; Smillie, LB | 1 |
| Cramer, F; Gottschalk, E; Heider, H | 1 |
| Grell, EH; Jacobson, KB; Twardzik, DR | 1 |
| Gusev, EI | 1 |
| Ansorge, S; Bohley, P | 1 |
| Demeyer, DI; Henderickx, HK | 1 |
| Ellis, S; McDonald, JK; Reilly, TJ; Zeitman, BB | 1 |
| Buddecke, E; Stein, U; Weber, U | 1 |
| Brown, JH; Mackey, HK | 1 |
| Brown, HH | 1 |
| Manahan, J; Mandl, I | 1 |
| Steenbergen, ST; Weinberg, ED | 1 |
| Meun, DH; Smith, KC | 1 |
| Holman, G; Lowe, JS; Morley, JS; Smithers, MJ | 1 |
| Busch, H; Roth, C; Sautiere, P; Starbuck, WC | 1 |
| Bonner, J; DeLange, RJ; Fambrough, DM; Smith, EL | 1 |
| Bairos, MA; Bairos, VA | 1 |
| Harman, RE; Patterson, JL; VandenHeuvel, WJ | 1 |
| Indada, Y; Matsushima, A; Nomoto, M; Sakurai, K; Shibata, K | 1 |
| Ota, S | 1 |
| Samofalova, MS | 1 |
| Gulian, EA; Kazarian, BA | 1 |
| Prenton, MA; Young, M | 1 |
| Landau, RL; Lugibihl, K | 1 |
| Kaplan, H; Whitaker, DR | 1 |
| Nishimura, S; Weinstein, IB | 1 |
| Beisel, WR; Dangerfield, HG; Feigin, RD | 1 |
| Gross, S; Maskaleris, ML; Milhorat, AT | 1 |
| Klein, PD; Szczepanik, PA | 1 |
| Gracy, RW; Horecker, BL; Lacko, AG | 1 |
| Menden, E; Vangala, RR | 1 |
| Gineitis, AA; Vinogradova, IA; Vorobyev, VI | 1 |
| Beyer, H; Schenk, U | 1 |
| Konikova, AS; Kritzman, MG; Morenkova, SA | 1 |
| Chaikoff, IL; Raghupathy, E; Singh, VN | 1 |
| Brenner, S; Kaplan, S; Stretton, AO | 1 |
| Gosztonyi, T; Kovács, A; Márton, J | 1 |
| Thornton, DR | 1 |
| Castles, JJ; Moyer, AN; Wool, IG | 1 |
| Baronowsky, P; Finn, F; Laursen, R; Shafer, J; Westheimer, FH | 1 |
| Dennis, ES; Goodchild, CG | 1 |
| Matsuzaki, K | 1 |
| Camien, MN | 1 |
| Huang, JM; Wang, IS; Wang, KT | 1 |
| Gurley, LR; Kischer, CW; Shepherd, GR | 1 |
| Jukes, TH | 1 |
| Ebata, M; Otsuka, H; Takahashi, Y | 1 |
| Aurich, H | 1 |
| Mella, K; Zahn, H | 1 |
| Gutermann, H; Waldschmidt-Leitz, E | 1 |
| Andreeva, LA | 1 |
| Carver, MJ; Ryan, WL | 1 |
| Fisher, JM; Hori, M; Rabinovitz, M | 1 |
| Bourke, JB; Massey, LM; Stillings, BR | 1 |
| Everett, GA; Kung, HK; Madison, JT | 1 |
| Adamson, LF; Ingbar, SH | 1 |
| Francis, FJ; Fuleki, T | 1 |
| Rigby, BJ | 1 |
| Alburn, HE; Grant, NH | 1 |
| Ikawa, M | 1 |
| Fujino, M; Ray, N; Showalter, M; Ward, DN | 1 |
| Estes, FL; Wetzel, RL | 1 |
| Harper, E; Scharrer, B; Seifter, S | 1 |
| Efron, ML; Mechanic, GL; Shih, VE | 1 |
| Oliver, IT; Yeung, D | 1 |
| Ingram, VM; Lee, JC | 1 |
| Robey, EA; Schachman, HK | 1 |
| Blomberg, J; Nalewaik, RP; Reynolds, FH; Stephenson, JR; Van de Ven, WJ | 1 |
| Sen, A | 1 |
| Blith, DL; Häring, HU; Kahn, CR; Karlsson, FA; Kasuga, M; Zick, Y | 1 |
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| Ayati, M; Bermea, KC; Everett, AD; Foster, DB; Fu, Z; Gabrielson, K; Heravi, A; Kim, HB; Medina, A; Murphy, AM; Na, CH; Paolocci, N; Ramirez-Correa, GA; Xu, M; Yang, X; Zhang, X | 1 |
| Basso, E; Füchtbauer, A; Füchtbauer, EM; Jensen, PH; Lassen, LB; Moos, T; Outeiro, TF; Thomsen, MS | 1 |
| Chen, D; Chen, L; Chen, T; He, L; Li, J; Lu, B; Lu, X; Shan, S; Song, D; Wang, J | 1 |
| Gizzio, J; Haldane, A; Levy, RM; Thakur, A | 1 |
| An, J; Jia, X; Li, X; Liu, R; Liu, S; Mo, Y; Wei, X; Zhang, S; Zhang, Y; Zhou, L | 1 |
| Brzozowski, JS; Dun, MD; Humphrey, SJ; Kahl, RGS; Miller, K; Murray, HC; Smith, ND; Verrills, NM | 1 |
| Bilmez, Y; Can, A; Kosebent, EG; Ozturk, S; Talibova, G; Tire, B | 1 |
| Ban, Q; Hou, YY; Huang, T; Ma, B; Shi, L; Zhang, ML; Zhang, Q; Zhou, YF | 1 |
| Che, L; Fang, Z; Feng, B; Hua, L; Jiang, X; Li, J; Lin, Y; Sun, M; Wang, Y; Xu, S; Zhuo, Y; Zou, X | 1 |
| Huntošová, V; Jancura, D; Pevná, V; Wagnières, G | 1 |
| Albillos, A; Arribas, RL; Jiménez-Pompa, A; McIntosh, JM | 1 |
| Khalid, A; O'Brien-Simpson, NM; Pyreddy, S; Qazi, F; Redmond, CE; Shukla, R; Tomljenovic-Hanic, S; Verma, R | 1 |
56 review(s) available for serine and tyrosine
| Article | Year |
|---|---|
Amino acid biosynthesis and its regulation.
Topics: Amino Acids; Arginine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Histidine; Phenylalanine; Pyruvates; Serine; Tyrosine | 1978 |
The role of Raf-1 phosphorylation in signal transduction.
Topics: Amino Acid Sequence; Animals; Cell Division; Enzyme Activation; Growth Substances; Humans; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Cell Surface; Serine; Signal Transduction; Substrate Specificity; Threonine; Tyrosine | 1992 |
Regulation of phospholipase C isozymes.
Topics: Animals; GTP-Binding Proteins; Isoenzymes; Molecular Structure; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylation; Serine; Tissue Distribution; Type C Phospholipases; Tyrosine | 1992 |
Tyrosine phosphatases and their possible interplay with tyrosine kinases.
Topics: Animals; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1992 |
Dual-specificity protein kinases: will any hydroxyl do?
Topics: Amino Acid Sequence; Animals; Humans; Hydroxylation; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Serine; Substrate Specificity; Threonine; Tyrosine | 1992 |
Molecular signal integration. Interplay between serine, threonine, and tyrosine phosphorylation.
Topics: Amino Acid Sequence; Molecular Sequence Data; Phosphorylation; Protein Kinases; Serine; Signal Transduction; Threonine; Tyrosine | 1992 |
Genetic amyloidosis: recent advances.
Topics: Alanine; Amyloidosis; DNA Mutational Analysis; Humans; Methionine; Polymorphism, Restriction Fragment Length; Prealbumin; Serine; Tyrosine | 1989 |
Protein-tyrosine kinases.
Topics: Amino Acid Sequence; Animals; Binding Sites; Epidermal Growth Factor; ErbB Receptors; Humans; Lipid Metabolism; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, Cell Surface; Retroviridae; Serine; Substrate Specificity; Threonine; Tyrosine; Viral Proteins | 1985 |
Insulin receptor kinase and its mode of signaling membrane components.
Topics: Animals; Enzyme Activation; ErbB Receptors; Humans; Insulin; Kinetics; Monosaccharide Transport Proteins; Phospholipids; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Serine; Threonine; Tyrosine | 1985 |
Noradrenergic influences on dopaminergic function and the pharmacology of dihydroxyphenylserine (DOPS): implication for Parkinson's disease.
Topics: Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Carbidopa; Dopamine; Droxidopa; Levodopa; Locus Coeruleus; Myocardium; Norepinephrine; Pargyline; Parkinson Disease; Serine; Stereoisomerism; Tyrosine | 1985 |
Evaluation of the chemiosmotic interpretation of active transport in bacterial membrane vesicles.
Topics: Benzenesulfonates; Biological Transport, Active; Carbon Radioisotopes; Cell Membrane; Cytochromes; Dinitrophenols; Escherichia coli; Kinetics; Lactose; Lysine; Mercury; NAD; Organoids; Organometallic Compounds; Oxygen Consumption; Potassium; Proline; Rubidium; Serine; Succinates; Tyrosine; Valinomycin | 1974 |
Utilization of D- and DL- amino acids and analogs.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chickens; Cystine; Histidine; Isomerism; Keto Acids; Leucine; Methionine; Nutritional Requirements; Phenylalanine; Proline; Rats; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1972 |
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methyldopa; Monoamine Oxidase Inhibitors; Parkinson Disease; Picolinic Acids; Rats; Serine; Time Factors; Tryptophan; Tyrosine | 1973 |
Genetics of amino acid transport in bacteria.
Topics: Alanine; Amino Acids; Amino Acids, Diamino; Arginine; Asparagine; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Cystine; Energy Metabolism; Escherichia coli; Genes, Regulator; Genetics, Microbial; Glutamates; Glutamine; Glycine; Histidine; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Invariant features of globin primary structure and coding of their secondary structure.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Globins; Glycine; Hemoglobins; Histidine; Myoglobin; Proline; Protein Conformation; Serine; Species Specificity; Threonine; Tyrosine | 1974 |
Microbial production of amino acids.
Topics: Amino Acids; Bacteria; Biotin; Chemical Industry; Glutamates; Isoleucine; Lysine; Phenylalanine; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
[Structure of transfer RNA].
Topics: Alanine; Chemical Phenomena; Chemistry; Phenylalanine; RNA, Transfer; Serine; Tyrosine; Valine | 1967 |
[Chemical cleavage of peptide bonds].
Topics: Amino Acids; Chemical Phenomena; Chemistry; Histidine; Methionine; Peptides; Proline; Serine; Threonine; Tryptophan; Tyrosine | 1968 |
Regulation of amino acid metabolism.
Topics: Amino Acids; Aspartic Acid; Bacteria; Enzyme Repression; Enzymes; Glutamates; Histidine; Models, Biological; Molecular Biology; Phenylalanine; Pyruvates; Serine; Tryptophan; Tyrosine | 1969 |
Chemical approaches to the properties of active sites of enzymes.
Topics: Amino Acids; Animals; Arginine; Bacteria; Binding Sites; Chemical Phenomena; Chemistry; Enzymes; Fungi; Histidine; Humans; Indicators and Reagents; Lysine; Metals; Methionine; Plants; Serine; Sulfhydryl Compounds; Tryptophan; Tyrosine | 1969 |
[Multiplicity and specificity in code recognition of tRNA against specific amino acid].
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chromatography; Cystine; Escherichia coli; Genetic Code; Genetics, Microbial; Glutamates; Glycine; Guinea Pigs; Histidine; Isoleucine; Leucine; Liver; Lysine; Phenylalanine; Rabbits; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Serine; Threonine; Tyrosine; Yeasts | 1969 |
Adverse effects of excessive consumption of amino acids.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Animal; Ethionine; Fenclonine; Glycine; Growth Disorders; Histidine; Humans; Methionine; Nerve Tissue Proteins; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pneumonia, Atypical Interstitial, of Cattle; Serine; Stereoisomerism; Sulfhydryl Compounds; Tissue Distribution; Tryptophan; Tyrosine; Vitamin A | 1984 |
The insulin receptor and tyrosine protein kinase activity.
Topics: Adenosine Triphosphate; Animals; Avian Sarcoma Viruses; Cations, Divalent; Cell Membrane; Cell Transformation, Viral; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Insulin; Macromolecular Substances; Molecular Weight; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Serine; Substrate Specificity; Tyrosine | 1984 |
[The insulin receptor: an autonomous system for membrane transmission of the hormonal message].
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Insulin; Liver; Molecular Weight; Phosphorylation; Protein Kinases; Receptor, Insulin; Serine; Threonine; Tyrosine | 1984 |
[Structure and function of luliberin (author's transl)].
Topics: Chemical Phenomena; Chemistry; Follicle Stimulating Hormone; Glycine; Gonadotropin-Releasing Hormone; Histidine; Humans; Leucine; Luteinizing Hormone; Molecular Conformation; Pyrrolidonecarboxylic Acid; Serine; Tryptophan; Tyrosine | 1980 |
In vivo chemical modification of proteins (post-translational modification).
Topics: Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Glutamates; Glutamine; Histidine; Hydroxylysine; Lysine; Phenylalanine; Proline; Protein Biosynthesis; RNA, Transfer, Amino Acyl; Serine; Threonine; Tryptophan; Tyrosine | 1981 |
A survey of inborn errors of amino acid metabolism and transport in man.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Amino Acids, Branched-Chain; Biological Transport; Cystinosis; Female; Glutathione; Glycine; Homocystinuria; Humans; Hydroxyproline; Infant; Infant, Newborn; Lysine; Maple Syrup Urine Disease; Phenylalanine; Proline; Serine; Tyrosine; Urea; Valine | 1981 |
Structure-function relationships in pyruvate decarboxylase of yeast and wheat germ.
Topics: Acetylation; Amino Acids; Apoenzymes; Arginine; Carboxy-Lyases; Chemical Phenomena; Chemistry; Circular Dichroism; Lysine; Macromolecular Substances; Plants; Protein Conformation; Protein Denaturation; Pyruvate Decarboxylase; Saccharomyces cerevisiae; Serine; Structure-Activity Relationship; Sulfhydryl Compounds; Thiamine Pyrophosphate; Triticum; Tryptophan; Tyrosine | 1982 |
Insulin and IGF-1 signaling in oocyte maturation.
Topics: Animals; Cellular Senescence; Genes, ras; Humans; Insulin; Insulin-Like Growth Factor I; Oocytes; Phosphorylation; Serine; Signal Transduction; Threonine; Tyrosine | 1994 |
NMR, alcohols, protein solvation and protein denaturation.
Topics: Alcohols; Magnetic Resonance Spectroscopy; Protein Conformation; Protein Denaturation; Proteins; Serine; Solvents; Threonine; Tyrosine | 1994 |
Protein phosphatases.
Topics: Humans; Models, Molecular; Phosphoprotein Phosphatases; Phosphorylation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Serine; src Homology Domains; Substrate Specificity; Threonine; Tyrosine | 1995 |
Regulation of potassium channels by protein kinases.
Topics: Animals; Cell Membrane; Enzyme Activation; Humans; Kinetics; Phosphorylation; Potassium Channels; Protein Kinases; Serine; Threonine; Tyrosine | 1996 |
[Peptide synthesis aiming at elucidation and creation of protein functions].
Topics: Amino Acid Sequence; Cholecystokinin; Dimethylformamide; Ion Channels; Molecular Sequence Data; Peptides; Protein Engineering; Serine; Sulfur Oxides; Trifluoroacetic Acid; Tyrosine | 1998 |
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Topics: Adolescent; Amino Acid Motifs; Amino Acid Sequence; Animals; B-Lymphocytes; Cell Line, Transformed; Cell Transformation, Viral; Epithelial Cells; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Mice; Mice, Transgenic; Molecular Sequence Data; Phosphorylation; Point Mutation; Proline; Protein Conformation; Protein Processing, Post-Translational; Sequence Deletion; Serine; Signal Transduction; src Homology Domains; Threonine; Tumor Virus Infections; Tyrosine; Viral Matrix Proteins; Virus Latency | 2000 |
Cortactin: coupling membrane dynamics to cortical actin assembly.
Topics: Actins; Animals; Cortactin; Humans; Microfilament Proteins; Models, Biological; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Serine; Signal Transduction; Threonine; Tyrosine | 2001 |
Diversity in the serine recombinases.
Topics: Bacteria; Bacteriophages; Base Sequence; DNA Nucleotidyltransferases; Genetic Variation; Molecular Sequence Data; Phylogeny; Recombinases; Serine; Substrate Specificity; Tyrosine | 2002 |
AMINO ACID METABOLISM.
Topics: Amino Acid Oxidoreductases; Amino Acids; Carboxy-Lyases; Glutamates; Glycine; Hydroxyproline; Lysine; Peroxidases; Phenylalanine; Proline; Proteins; Pyridoxal Phosphate; Research; Serine; Threonine; Transaminases; Tryptophan; Tyrosine; Urea | 1963 |
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
Topics: AMP-Activated Protein Kinases; Animals; Fatty Acids, Nonesterified; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Multienzyme Complexes; Peroxisome Proliferator-Activated Receptors; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoid X Receptors; Serine; Signal Transduction; Stress, Physiological; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Regulation of hemidesmosome disassembly by growth factor receptors.
Topics: Amino Acid Sequence; Animals; Epithelial Cells; Hemidesmosomes; Humans; Integrin alpha6beta4; Models, Molecular; Molecular Sequence Data; Phosphorylation; Plectin; Receptors, Growth Factor; Sequence Alignment; Serine; Signal Transduction; Tyrosine | 2008 |
STAT3 revs up the powerhouse.
Topics: Animals; Cell Transformation, Neoplastic; Genes, ras; Humans; Mitochondria; Models, Biological; Oncogenes; Oxidative Phosphorylation; Phosphorylation; ras Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2009 |
Topoisomerases and site-specific recombinases: similarities in structure and mechanism.
Topics: Base Sequence; Binding Sites; Catalytic Domain; Conserved Sequence; DNA; DNA Cleavage; DNA Nucleotidyltransferases; DNA Topoisomerases; Gene Expression; Protein Conformation; Serine; Tyrosine | 2010 |
eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity.
Topics: Amino Acid Sequence; Animals; Biopterins; Cell Membrane; Dimerization; Enzyme Activation; Humans; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Quaternary; Serine; Threonine; Tyrosine | 2011 |
Agents of change - concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling.
Topics: Gene Expression Regulation, Bacterial; Mycobacterium tuberculosis; Phosphorylation; Protein Kinases; Serine; Signal Transduction; Threonine; Tyrosine | 2014 |
Acute regulation of PDK1 by a complex interplay of molecular switches.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Dimerization; Enzyme Activation; Humans; Ligands; Models, Molecular; Neoplasm Proteins; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Protein Transport; Serine; Signal Transduction; Threonine; Tyrosine | 2014 |
Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.
Topics: Asian People; Genetic Predisposition to Disease; Humans; Parkinson Disease; Polymorphism, Single Nucleotide; Serine; Tyrosine; Ubiquitin Thiolesterase | 2014 |
Serine/threonine/tyrosine phosphorylation regulates DNA binding of bacterial transcriptional regulators.
Topics: Bacterial Proteins; Gene Expression Regulation, Bacterial; Histidine Kinase; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Threonine; Transcription Factors; Tyrosine | 2015 |
Chemical Approaches to Studying Labile Amino Acid Phosphorylation.
Topics: Amino Acids; Humans; Phosphorylation; Proteins; Serine; Threonine; Tyrosine | 2017 |
The RNA polymerase II CTD "orphan" residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7.
Topics: Humans; RNA Polymerase II; Serine; Threonine; Transcription, Genetic; Tyrosine | 2018 |
Protein phosphorylation and its role in the regulation of Annexin A2 function.
Topics: Annexin A2; Cell Transformation, Neoplastic; Exosomes; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Ribonucleoproteins; S100 Proteins; Serine; Tyrosine | 2017 |
Recent advances in methods for the analysis of protein o-glycosylation at proteome level.
Topics: Animals; Cattle; Cell Line; CHO Cells; Chromatography, Affinity; Cricetinae; Cricetulus; Drosophila; Glycosylation; HEK293 Cells; HeLa Cells; Humans; Hydrazines; Jurkat Cells; Lectins; MCF-7 Cells; Mice; Phosphorylation; Polysaccharides; Protein Processing, Post-Translational; Proteins; Proteomics; Serine; Tyrosine | 2018 |
[Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction].
Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Atorvastatin; Diabetes Mellitus; Dual-Specificity Phosphatases; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase Phosphatases; Phosphorylation; rho-Associated Kinases; rhoA GTP-Binding Protein; Serine; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2018 |
Importance of protein Ser/Thr/Tyr phosphorylation for bacterial pathogenesis.
Topics: Animals; Bacteria; Bacterial Infections; Bacterial Proteins; Humans; Phosphoproteins; Phosphorylation; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine | 2020 |
[Advancesin enrichment and detection methods for
Topics: Arginine; Histidine; Lysine; Phosphorylation; Proteins; Serine; Threonine; Tyrosine | 2020 |
Protein Tyrosine and Serine/Threonine Phosphorylation in Oral Bacterial Dysbiosis and Bacteria-Host Interaction.
Topics: Dental Caries; Dysbiosis; Host Microbial Interactions; Humans; Microbiota; Phosphorylation; Porphyromonas gingivalis; Serine; Threonine; Tyrosine | 2021 |
Importance of Tyrosine Phosphorylation in Hormone-Regulated Plant Growth and Development.
Topics: Animals; Biological Phenomena; Hormones; Phosphorylation; Plant Development; Plant Growth Regulators; Plants; Protein Processing, Post-Translational; Serine; Threonine; Tyrosine | 2022 |
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Humans; Microtubules; Neoplasms; Neurodegenerative Diseases; NF-kappa B; Phosphates; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Serine; Threonine; TOR Serine-Threonine Kinases; Tyrosine | 2022 |
3 trial(s) available for serine and tyrosine
| Article | Year |
|---|---|
[The significance of nonessential amino acids for the human nitrogen metabolism during parenteral feeding].
Topics: Adult; Aged; Alanine; Amino Acids; Citrulline; Cystine; Diet; Female; Glycine; Humans; Male; Middle Aged; Nitrogen; Parenteral Nutrition; Proline; Serine; Taurine; Tyrosine | 1968 |
Intracellular amino acids in uremia.
Topics: Adolescent; Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Body Fluids; Dietary Proteins; Female; Humans; Intracellular Fluid; Keto Acids; Male; Middle Aged; Muscles; Nitrogen; Renal Dialysis; Serine; Tyrosine; Uremia | 1983 |
Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial.
Topics: Adult; Aged; Alanine; Amino Acids; Aspartic Acid; Double-Blind Method; Glutamic Acid; Humans; Mental Fatigue; Mental Health; Middle Aged; Occupational Health; Serine; Treatment Outcome; Tyrosine; Young Adult | 2022 |
1309 other study(ies) available for serine and tyrosine
| Article | Year |
|---|---|
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Topics: Amino Acid Transport Systems; Amino Acids; Biological Transport; Catalytic Domain; Dipeptides; Gene Expression Regulation, Fungal; Mutagenesis; Protein Conformation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction | 2009 |
Mechanism of discrimination between cognate and non-cognate tRNAs by phenylalanyl-tRNA synthetase from yeast.
Topics: Amino Acyl-tRNA Synthetases; Enzyme Activation; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Magnesium; Osmolar Concentration; Phenylalanine-tRNA Ligase; RNA, Transfer; Saccharomyces cerevisiae; Serine; Species Specificity; Spectrometry, Fluorescence; Structure-Activity Relationship; Temperature; Tyrosine; Valine | 1976 |
Proton magnetic resonance titration curves of the three histidine residues of staphylococcal protease.
Topics: Amino Acids; Histidine; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Peptide Fragments; Peptide Hydrolases; Phenylalanine; Protein Conformation; Serine; Staphylococcus; Tyrosine | 1975 |
Purification and properties of a lipid acyl-hydrolase from potato tubers.
Topics: Binding Sites; Galactose; Glycerides; Glycolipids; Hydrogen-Ion Concentration; Kinetics; Lipase; Molecular Weight; Phosphatidylcholines; Phospholipids; Plants; Serine; Sulfhydryl Compounds; Tryptophan; Tyrosine | 1975 |
Phosphopeptides of enamel matrix.
Topics: Amino Acid Sequence; Binding Sites; Bone and Bones; Calcification, Physiologic; Calcium; Calcium Phosphates; Chemical Phenomena; Chemistry, Physical; Collagen; Crystallography; Dental Enamel; Dental Enamel Proteins; Glutamine; Humans; Leucine; Magnetic Resonance Spectroscopy; Models, Chemical; Phosphates; Phosphopeptides; Protein Conformation; Serine; Tooth Calcification; Tyrosine | 1979 |
Nonsense suppressors of yeast cause osmotic-sensitive growth.
Topics: Codon; Genotype; Leucine; Saccharomyces cerevisiae; Serine; Suppression, Genetic; Tyrosine; Water-Electrolyte Balance | 1977 |
Alteration of free serum amino acids in voles infected with Trypanosoma brucei gambiense.
Topics: Alanine; Amino Acids; Animals; Arvicolinae; Circadian Rhythm; Glutamates; Glycine; Isoleucine; Leucine; Male; Proline; Serine; Threonine; Trypanosomiasis, African; Tryptophan; Tyrosine; Valine | 1977 |
Use of 3H and 14C double-labeled glucose to assess in vivo pathways of amino acid biosynthesis in Escherichia coli.
Topics: Alanine; Amino Acids; Aspartic Acid; Carbon Radioisotopes; Escherichia coli; Glucose; Glutamates; Glycine; Glycolysis; Isoleucine; Leucine; Methionine; Radioactive Tracers; Serine; Tritium; Tyrosine; Valine | 1977 |
Ternary complex formation between elongation factor Tu, GTP and aminoacyl-tRNA: an equilibrium study.
Topics: Calorimetry; Drug Stability; Escherichia coli; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Macromolecular Substances; Peptide Elongation Factors; Phenylalanine; RNA, Transfer, Amino Acyl; Serine; Temperature; Thermodynamics; Tyrosine | 1977 |
Yeast UAA suppressors effective in psi+ strains serine-inserting suppressors.
Topics: Amino Acid Sequence; Chromosome Mapping; Codon; Mutation; Saccharomyces cerevisiae; Serine; Suppression, Genetic; Tyrosine | 1979 |
Side reactions in peptide synthesis. X. Prevention of O-acylation during coupling with active esters.
Topics: Acylation; Amino Acid Sequence; Dinitrophenols; Esters; Pentachlorophenol; Peptides; Serine; Threonine; Tyrosine | 1979 |
Structure of the schistosome eggshell: amino acid analysis and incorporation of labelled amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Carbohydrate Metabolism; Female; Glycine; Lysine; Mice; Ovum; Schistosoma japonicum; Schistosoma mansoni; Serine; Tyrosine | 1979 |
[Senile liver and its repercussions on cerebral activity].
Topics: Aged; Aging; Amino Acids; Brain; Cystine; Glutamates; Histidine; Humans; Liver; Serine; Threonine; Tyrosine | 1979 |
[Free amino acids in calf embryos].
Topics: Alanine; Amino Acids; Animals; Cattle; Embryo, Mammalian; Glycine; Histidine; Isoleucine; Leucine; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1979 |
Specific sulfonation of tyrosine, tryptophan and hydroxy-amino acids in peptides.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Peptides; Protein Binding; Serine; Sulfonic Acids; Sulfuric Acids; Threonine; Tryptophan; Tyrosine | 1979 |
[Normal range of free amino acids in cerebrospinal fluid of children (author's transl)].
Topics: Adolescent; Age Factors; Amino Acids; Aspartic Acid; Child; Child, Preschool; Citrulline; Female; Histidine; Humans; Infant; Lysine; Male; Methods; Serine; Sex Factors; Threonine; Tyrosine | 1977 |
Diurnal variations in plasma concentrations of tryptophan, tryosine, and other neutral amino acids: effect of dietary protein intake.
Topics: Adult; Alanine; Amino Acids; Circadian Rhythm; Dietary Proteins; Glycine; Humans; Isoleucine; Leucine; Male; Middle Aged; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1979 |
Diurnal variations in plasma neutral amino acid concentrations among patients with cirrhosis: effect of dietary protein.
Topics: Adult; Aged; Amino Acids; Circadian Rhythm; Dietary Proteins; Hepatic Encephalopathy; Humans; Isoleucine; Leucine; Liver Cirrhosis, Alcoholic; Male; Methionine; Middle Aged; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1979 |
Lack of hypotensive and brain catecholamine depleting effects by erythro- and threo-alpha-methyl DOPS.
Topics: Animals; Blood Pressure; Brain Chemistry; Catecholamines; Droxidopa; Drug Interactions; Rats; Serine; Time Factors; Tyrosine | 1979 |
Thin layer chromatographic analyses of amino acids in Echinostoma revolutum (Trematoda) adults.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Chromatography, Thin Layer; Echinostoma; Isoleucine; Leucine; Methionine; Proline; Serine; Tyrosine; Valine | 1977 |
Amino acid content of erythrocytes in uremia.
Topics: Alanine; Amino Acids; Erythrocytes; Histidine; Humans; Renal Dialysis; Serine; Tyrosine; Uremia | 1978 |
Linkage of the N-terminal peptide portion of renin substrate to the remainder of the protein. Evidence for an alkali-labile Tyr-Ser and against an ester bond.
Topics: Amino Acid Sequence; Amino Acids; Angiotensinogen; Angiotensins; Animals; Esters; Hydrazines; Hydroxylamines; Peptides; Protein Binding; Serine; Swine; Tyrosine | 1978 |
Variations in the concentrations of blood plasma free amino acids in suckled and fasted neonatal pigs.
Topics: Amino Acids; Animals; Animals, Newborn; Arginine; Cystine; Fasting; Glycine; Leucine; Lysine; Proline; Serine; Swine; Threonine; Tyrosine | 1977 |
Molecular aspects of chloride cell formation in Oncorhynchus. II. Isolation and characterization of gill transfer RNA's during active salt secretion.
Topics: Acylation; Amino Acids; Animals; Aspartic Acid; Cell Differentiation; Chlorides; Epithelial Cells; Epithelium; Gills; In Vitro Techniques; RNA, Transfer; Salmon; Serine; Sodium Chloride; Tyrosine | 1977 |
Rotational isomerism of N-acetylamino acid methylamides having serine, tyrosine, histidine, and proline residues as revealed by Raman spectroscopy.
Topics: Histidine; Isomerism; Optical Rotation; Peptides; Proline; Protein Conformation; Serine; Spectrum Analysis, Raman; Tyrosine | 1977 |
Cholecystokinin (pancreozymin). 3. Synthesis and properties of an analogue of the C-terminal heptapeptide with serine sulfate replacing tyrosine sulfate.
Topics: Animals; Calcium; Calcium Radioisotopes; Cholecystokinin; Guinea Pigs; In Vitro Techniques; Oligopeptides; Pancreas; Serine; Structure-Activity Relationship; Tyrosine | 1977 |
[Inhibition of harmaline induced tremor by L-threo-3, 4-dihydroxyphenylserine, an L-norepinephrine precursor].
Topics: Alkaloids; Animals; Brain Chemistry; Droxidopa; Drug Synergism; Harmaline; Isomerism; Locomotion; Male; Mice; Norepinephrine; Serine; Serotonin; Tremor; Tremorine; Tyrosine | 1976 |
Amino acid metabolism in Friedreich's ataxia.
Topics: Alanine; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Friedreich Ataxia; Glycine; Histidine; Humans; Isoleucine; Ornithine; Phenylalanine; Phosphatidylethanolamines; Sarcosine; Serine; Taurine; Tyrosine; Valine | 1976 |
Plasma amino acids in children and adolescents on hemodialysis.
Topics: Adolescent; Amino Acids; Child; Child Nutritional Physiological Phenomena; Citrulline; Diet; Female; Glycine; Growth; Histidine; Humans; Isoleucine; Leucine; Lysine; Male; Methylhistidines; Nutritional Physiological Phenomena; Proline; Renal Dialysis; Serine; Tyrosine; Valine | 1976 |
[Important role of C-terminal amino acid sequence of the luteinizing hormone alpha-subunit in its recombination with the beta-subunit].
Topics: Amino Acid Sequence; Animals; Carboxypeptidases; Cattle; Chromatography, Gel; Histidine; Luteinizing Hormone; Lysine; Serine; Tyrosine | 1976 |
Amino acid composition, distribution and origin of "tuft" protein in human and bovine dental enamel.
Topics: Alanine; Amelogenesis; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Dental Enamel; Dental Enamel Proteins; Glutamates; Glycine; Histidine; Humans; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1975 |
Positive selection of general amino acid permease mutants in Saccharomyces cerevisiae.
Topics: Amino Acids; Ammonium Sulfate; Biological Transport, Active; Carbon Radioisotopes; Diploidy; Genetic Complementation Test; Histidine; Membrane Transport Proteins; Mutation; Proline; Saccharomyces cerevisiae; Serine; Stereoisomerism; Tyrosine | 1975 |
Paucity of sites mutable to constitutivity in the araC activator gene of the L-arabinose operon of Escherichia coli.
Topics: Arabinose; Chromosome Mapping; Cytarabine; Escherichia coli; Fucose; Genes; Genotype; Glutamine; Leucine; Lysine; Mutation; Operon; Recombination, Genetic; Serine; Species Specificity; Tyrosine | 1975 |
Equivalent and non-equivalent binding sites for tRNA on aminoacyl-tRNA synthetases.
Topics: Amino Acyl-tRNA Synthetases; Escherichia coli; Kinetics; Macromolecular Substances; Magnesium; Mathematics; Molecular Weight; Phenylalanine; Phenylalanine-tRNA Ligase; Protein Binding; RNA, Transfer; Saccharomyces cerevisiae; Serine; Serine-tRNA Ligase; Spectrophotometry, Ultraviolet; Tyrosine; Tyrosine-tRNA Ligase | 1975 |
An improved technique for the analysis of amino acids and related compounds on thin layers of cellulose. X. The characterization of some methionyl, phenylalanyl, tyrosyl and other peptides by thin-layer and ion-exchange chromatography.
Topics: Amino Acids; Aspartic Acid; Chromatography; Chromatography, Ion Exchange; Chromatography, Thin Layer; Densitometry; Dipeptides; Glutamates; Methionine; Methods; Peptides; Phenylalanine; Serine; Solvents; Tyrosine | 1975 |
Ligand-exchange chromatography of amino acids on copper-, cobalt- and zinc-chelex 100.
Topics: Amino Acids; Ammonia; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Cobalt; Copper; Cysteine; Glutamates; Histidine; Ion Exchange Resins; Ligands; Lysine; Phenylalanine; Quaternary Ammonium Compounds; Serine; Threonine; Tyrosine; Zinc | 1975 |
Synthesis by conventional methods of human growth hormone peptide fragments. I.
Topics: Alanine; Asparagine; Aspartic Acid; Glutamine; Growth Hormone; Histidine; Humans; Leucine; Lysine; Optical Rotation; Peptides; Phenylalanine; Serine; Threonine; Tyrosine | 1975 |
Sequential polypeptides. Part X. The synthesis of some sequential polypeptide collagen models with functional side-chains.
Topics: Amino Acid Sequence; Collagen; Glutamine; Glycine; Lysine; Peptides; Proline; Serine; Tyrosine | 1975 |
[Biosynthesis of soluble proteins and pepsinogen of the mucus membrane and cancer of the stomach in man].
Topics: Gastric Mucosa; Humans; Pepsinogens; Protein Biosynthesis; Serine; Stomach Neoplasms; Tyrosine | 1975 |
Synthesis of L-tyrosine-related amino acids by beta-tyrosinase.
Topics: Amino Acids; Ammonia; Catalysis; Catechols; Cell-Free System; Chemical Phenomena; Chemistry; Crystallization; Dihydroxyphenylalanine; Enzyme Induction; Erwinia; Escherichia; Lyases; Molecular Weight; Phenols; Pyridoxal Phosphate; Pyruvates; Sepharose; Serine; Stereoisomerism; Tyrosine; Tyrosine Phenol-Lyase | 1975 |
Amino acid biosynthesis in mixed rumen cultures.
Topics: Alanine; Amino Acids; Animals; Bacteria; Cattle; Citric Acid Cycle; Female; Fumarates; Isoleucine; Ketoglutaric Acids; Leucine; Lysine; Oxaloacetates; Oxidation-Reduction; Phenylalanine; Propionates; Pyruvates; Rumen; Serine; Tyrosine; Valine | 1975 |
[Free amino acids in the amniotic fluid and in maternal blood in advanced pregnancy].
Topics: Alanine; Amino Acids; Amniotic Fluid; Cysteine; Female; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Pregnancy Trimester, Third; Proline; Serine; Threonine; Tyrosine; Valine | 1975 |
[Growth and sexual reproduction of the dermatophyte Arthroderma vanbreuseghemii Takashio (Trichophyton mentagrophytes (Robin blanchard) on a synthetic medium].
Topics: Amino Acids; Ascomycota; Aspartic Acid; Conjugation, Genetic; Culture Media; Glucose; Glutamates; Phenylalanine; Serine; Shikimic Acid; Tryptophan; Tyrosine | 1975 |
[The pattern of distribution of free amino acids in human amniotic fluid related to the duration of pregnancy. Part I: Changes in concentration in normal pregnancy (author's transl)].
Topics: Alanine; Amino Acids; Amniotic Fluid; Chromatography, Gas; Cysteine; Female; Gestational Age; Glycine; Humans; Hydroxyproline; Methionine; Ornithine; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1976 |
Hydration of amino acid side chains: dependence on secondary structure.
Topics: Amino Acids; Computer Simulation; Hydrogen Bonding; Mathematical Computing; Models, Chemical; Models, Molecular; Protein Structure, Secondary; Serine; Software; Threonine; Tyrosine; Water | 1992 |
Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Molecular Sequence Data; Mutation; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Rabbits; Rats; Serine; Signal Transduction; Threonine; Tyrosine | 1992 |
A purified S6 kinase kinase from Xenopus eggs activates S6 kinase II and autophosphorylates on serine, threonine, and tyrosine residues.
Topics: Animals; Caseins; Cell Line; Chromatography, Gel; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Histones; Isoenzymes; Phosphoric Monoester Hydrolases; Phosphorylation; Phosvitin; Protamines; Protein Kinase Inhibitors; Protein Kinases; Ribosomal Protein S6 Kinases; Serine; Substrate Specificity; Threonine; Tyrosine; Xenopus | 1992 |
Involvement of MAP kinase activators in angiotensin II-induced activation of MAP kinases in cultured vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromatography, DEAE-Cellulose; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinases; Rats; Serine; Threonine; Tyrosine | 1992 |
Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; Substrate Specificity; Thymidine; Transfection; Tyrosine | 1992 |
Role of serine 214 and tyrosine 171, components of the S2 subsite of alpha-lytic protease, in catalysis.
Topics: Base Sequence; Blotting, Western; Catalysis; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotides; Plasmids; Protein Conformation; Restriction Mapping; Serine; Serine Endopeptidases; Tyrosine | 1992 |
The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cattle; Cell Division; Cell Line; Epidermal Growth Factor; Humans; Mice; Molecular Sequence Data; Oncogene Proteins; Peptide Mapping; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Rats; Sequence Homology, Amino Acid; Serine; Sulfhydryl Compounds; Type C Phospholipases; Tyrosine | 1992 |
Novel protein kinase of Arabidopsis thaliana (APK1) that phosphorylates tyrosine, serine and threonine.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Base Sequence; Blotting, Southern; Cloning, Molecular; DNA; Escherichia coli; Humans; Immunoblotting; Molecular Sequence Data; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; Serine; Threonine; Tyrosine | 1992 |
The comparative efficiencies of the Ser(P)-, Thr(P)- and Tyr(P)-residues as specificity determinants for casein kinase-1.
Topics: Amino Acid Sequence; Casein Kinases; Indicators and Reagents; Kinetics; Molecular Sequence Data; Oligopeptides; Protein Kinases; Serine; Substrate Specificity; Threonine; Tyrosine | 1992 |
Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells.
Topics: Cell Membrane; Cells, Cultured; Cycloheximide; Enzyme Activation; Epithelial Cells; Epithelium; Glucuronosyltransferase; Glycosyltransferases; Humans; Hyaluronan Synthases; Kinetics; Membrane Proteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Biosynthesis; Protein Kinase C; Serine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Threonine; Transferases; Transforming Growth Factor beta; Tyrosine; Vanadates; Xenopus Proteins | 1992 |
Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Humans; Mutagenesis, Insertional; Mutagenesis, Site-Directed; Restriction Mapping; Rhodopsin; Serine; Spectrophotometry; Threonine; Transfection; Tyrosine | 1992 |
DIDS-effect on Ser/Thr- and Tyr-phosphorylation of membrane proteins in human erythrocytes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Binding Sites; Erythrocyte Membrane; Humans; In Vitro Techniques; Membrane Proteins; Phosphorylation; Serine; Spectrin; Threonine; Tyrosine | 1992 |
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity.
Topics: Animals; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Kinase Inhibitors; Protein Kinases; Protein Phosphatase 1; Rabbits; Rats; Serine; Threonine; Tyrosine | 1991 |
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody.
Topics: Antibodies, Monoclonal; Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Half-Life; Methylamines; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Determination of dityrosine, phosphotyrosine, phosphothreonine, and phosphoserine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Microchemistry; p-Dimethylaminoazobenzene; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Serine; Threonine; Tyrosine | 1990 |
[Phosphoamino acid analysis by 2-dimensional electrophoresis].
Topics: Electrophoresis, Gel, Two-Dimensional; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1990 |
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.
Topics: Animals; Base Sequence; Cell Line; Hydrolysis; Isoenzymes; Molecular Sequence Data; Mutation; Peptides; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Serine; Transfection; Type C Phospholipases; Tyrosine | 1991 |
The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.
Topics: Animals; Antibodies, Monoclonal; Chick Embryo; Mutagenesis; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Sequence Homology, Nucleic Acid; Serine; Structure-Activity Relationship; Subcellular Fractions; Threonine; Tyrosine | 1991 |
Insulin-stimulated tyrosine phosphorylation of a 43 kDa protein in rat liver membranes.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Insulin; Membrane Proteins; Microsomes, Liver; Molecular Weight; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Restriction Mapping; Serine; Tyrosine | 1991 |
Signal transduction in human B cells during aging: alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness.
Topics: Aging; Amino Acids; B-Lymphocytes; Calcium; Cell Division; Cells, Cultured; Cytosol; Humans; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Ribonucleases; Serine; Signal Transduction; Threonine; Tyrosine | 1991 |
CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Blotting, Western; CD3 Complex; Cell Line; Humans; Isoenzymes; Peptide Mapping; Phosphorylation; Precipitin Tests; Receptors, Antigen, T-Cell; Serine; T-Lymphocytes; Trypsin; Type C Phospholipases; Tyrosine | 1991 |
Changes in insulin-receptor tyrosine, serine and threonine phosphorylation as a result of substitution of tyrosine-1162 with phenylalanine.
Topics: Amino Acid Sequence; Animals; Cell Line; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphopeptides; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Serine; Threonine; Transfection; Trypsin; Tyrosine | 1991 |
Interleukin 2 stimulates serine phosphorylation of CD45 in CTLL-2.4 cells.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Cells, Cultured; Histocompatibility Antigens; Interleukin-2; Leukocyte Common Antigens; Mice; Phosphoprotein Phosphatases; Phosphorylation; Protein Tyrosine Phosphatases; Serine; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1991 |
Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors.
Topics: ErbB Receptors; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Recombinant Proteins; Serine; Threonine; Tyrosine | 1991 |
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity.
Topics: Base Sequence; Computer Simulation; DNA; DNA Polymerase I; DNA Replication; Escherichia coli; Kinetics; Molecular Sequence Data; Mutation; Phenylalanine; Serine; Tyrosine | 1991 |
Spk1, a new kinase from Saccharomyces cerevisiae, phosphorylates proteins on serine, threonine, and tyrosine.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Cycle Proteins; Checkpoint Kinase 2; Cloning, Molecular; Escherichia coli; Fungal Proteins; Gene Library; Genes, Fungal; Immunoblotting; Molecular Sequence Data; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Nucleic Acid; Serine; Substrate Specificity; Threonine; Tyrosine | 1991 |
Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second-site mutation is capable of reverting an internalization-defective phenotype.
Topics: Amino Acid Sequence; Animals; Cell Line; Coated Pits, Cell-Membrane; Cricetinae; Cytoplasm; Endocytosis; Humans; Iron; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenotype; Phenylalanine; Receptors, Transferrin; Serine; Tyrosine | 1991 |
Identification and characterization of a novel cytoskeleton-associated pp60src substrate.
Topics: Amino Acid Sequence; Animals; Avian Proteins; Base Sequence; Blotting, Northern; Blotting, Western; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Cloning, Molecular; Cytoskeletal Proteins; Cytoskeleton; Microscopy, Fluorescence; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Protein Conformation; Repetitive Sequences, Nucleic Acid; Serine; Threonine; Tyrosine | 1991 |
Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.
Topics: Amino Acid Sequence; Animals; Cell Communication; Cell Division; Connexins; Gene Expression; Membrane Proteins; Microinjections; Molecular Sequence Data; Oncogene Protein pp60(v-src); Oocytes; Phosphorylation; RNA, Messenger; Serine; Tyrosine; Xenopus | 1990 |
Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Biological Transport; Carbon Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chamomile; Flavones; Flavonoids; Glutamates; Glutamic Acid; Histidine; Lysine; Oils, Volatile; Plants, Medicinal; Quercetin; Serine; Tyrosine | 1990 |
Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding.
Topics: Amino Acid Sequence; Asialoglycoproteins; Binding Sites; Blood Platelets; Crotalid Venoms; Disulfides; Humans; Molecular Sequence Data; Peptide Fragments; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Ristocetin; Serine; Tyrosine; von Willebrand Factor | 1990 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Metabolic depletion effect on serine/threonine- and tyrosine-phosphorylations of membrane proteins in human erythrocytes.
Topics: Autoradiography; Biological Transport; Casein Kinases; Cell Membrane Permeability; Cytosol; Erythrocyte Membrane; Erythrocytes; Humans; Membrane Proteins; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1990 |
Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.
Topics: Animals; Diglycerides; Gene Amplification; Gene Expression; Humans; Phorbol Esters; Phosphorylation; Precipitin Tests; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Serine; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Influence of secondary structure on the hydration of serine, threonine and tyrosine residues in proteins.
Topics: Amino Acids; Protein Conformation; Proteins; Serine; Stereoisomerism; Threonine; Tyrosine; Water; X-Ray Diffraction | 1990 |
Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Interleukin-3; Interleukin-5; Kinetics; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Receptors, Immunologic; Receptors, Interleukin; Receptors, Interleukin-3; Receptors, Interleukin-5; Serine; Tyrosine | 1990 |
Effects of protein phosphorylation with p43v-abl and protein kinase A catalytic subunit on fluorescence intensity.
Topics: Histones; Phosphopyruvate Hydratase; Phosphorylation; Protein Conformation; Protein Kinases; Serine; Spectrometry, Fluorescence; Threonine; Tyrosine | 1990 |
A simple and rapid method of quantitative analysis of phosphoamino acids by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1985 |
12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Viral; Diglycerides; Mice; Molecular Weight; Mutation; Oncogene Proteins, Viral; Phorbols; Phosphorylation; Polyomavirus; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase.
Topics: Amino Acid Sequence; Animals; Brain; Calmodulin; Cattle; Fluorides; Kinetics; Manganese; Myocardium; Myosins; Nickel; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphoserine; Phosphotyrosine; Protein Tyrosine Phosphatases; Serine; Tyrosine; Vanadates; Vanadium; Zinc | 1986 |
Resolution and identification of O-phosphoserine, O-phosphothreonine, O-phosphotyrosine, and gamma-carboxyglutamic acid as their fluorescent o-phthalaldehyde derivatives by high performance liquid chromatography.
Topics: 1-Carboxyglutamic Acid; Animals; Chromatography, High Pressure Liquid; Fluorescent Dyes; o-Phthalaldehyde; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1986 |
gp140v-fms molecules expressed at the surface of cells transformed by the McDonough strain of feline sarcoma virus are phosphorylated in tyrosine and serine.
Topics: Animals; Cats; Cell Transformation, Neoplastic; Genes; Genes, Viral; Oncogene Protein gp140(v-fms); Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Retroviridae; Retroviridae Proteins; Serine; Tyrosine; Vanadates; Vanadium | 1986 |
In vivo effect of sodium orthovanadate on pp60c-src kinase.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Fibroblasts; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Serine; Tyrosine; Vanadates; Vanadium | 1987 |
Epidermal growth factor stimulates serine and tyrosine phosphorylation in a 59-kD protein in purified plasma membranes from rat liver.
Topics: Animals; Endopeptidases; Epidermal Growth Factor; Liver; Male; Membrane Proteins; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Inbred Strains; Serine; Serine Endopeptidases; Tyrosine | 1987 |
Determination of [32P]phosphoamino acids in protein hydrolysates by isocratic anion-exchange high-performance liquid chromatography.
Topics: Buffers; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrogen-Ion Concentration; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Hydrolysates; Serine; Spectrophotometry, Ultraviolet; Threonine; Tyrosine | 1988 |
Characterization of sites of serine phosphorylation in human placental insulin receptor copurified with insulin-stimulated serine kinase activity by two-dimensional thin-layer peptide mapping.
Topics: Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphotyrosine; Placenta; Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Insulin; Serine; Tyrosine | 1989 |
Serine and tyrosine phosphorylation of 28- and 35-kDa proteins of human T lymphocytes stimulated by streptococcal M protein.
Topics: Antigens, Bacterial; Antigens, Differentiation, T-Lymphocyte; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Humans; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Phytohemagglutinins; Serine; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Tyrosine | 1989 |
Thin-layer chromatography can resolve phosphotyrosine, phosphoserine, and phosphothreonine in a protein hydrolyzate.
Topics: Animals; Autoradiography; Chromatography, Thin Layer; Humans; Hydrolysis; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Threonine; Tyrosine | 1989 |
Antibodies and radioimmunoassays for phosphoserine, phosphothreonine and phosphotyrosine. Serologic specificities and levels of the phosphoamino acids in cytoplasmic fractions of rat tissues.
Topics: Animals; Antibodies; Antibody Specificity; Chromatography, Ion Exchange; Cytoplasm; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred F344; Serine; Serum Albumin, Bovine; Threonine; Tyrosine | 1989 |
The influence of tryptophan on mobility of residues in the trp repressor of Escherichia coli.
Topics: Bacterial Proteins; DNA-Binding Proteins; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Lysine; Magnetic Resonance Spectroscopy; Molecular Conformation; Operator Regions, Genetic; Repressor Proteins; Serine; Temperature; Tetranitromethane; Transcription Factors; Tryptophan; Tyrosine | 1989 |
Threonine phosphorylation is associated with mitosis in HeLa cells.
Topics: Antibodies; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Interphase; Mitosis; Phosphorylation; Serine; Threonine; Tyrosine | 1989 |
Regulation of the insulin receptor kinase by hyperinsulinism.
Topics: Animals; Blotting, Western; Cell Line; Humans; Hyperinsulinism; Mice; Molecular Weight; Phosphorylation; Protein Kinases; Receptor, Insulin; Serine; Substrate Specificity; Threonine; Transfection; Tyrosine | 1989 |
Some observations on the replacement of the conserved amino acid residues of immunoglobulin domains.
Topics: Alanine; Amino Acids; beta 2-Microglobulin; Computer Graphics; Cysteine; Immunoglobulin Constant Regions; Immunoglobulin Variable Region; Immunoglobulins; Leucine; Serine; Tryptophan; Tyrosine | 1989 |
Cellular and biochemical responses of human T lymphocytes stimulated with streptococcal M proteins.
Topics: Antigens, Bacterial; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Cross Reactions; Humans; Lymphocyte Activation; Myocardium; Phosphorylation; Serine; T-Lymphocytes; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tyrosine | 1989 |
Tyrosine-kinase defect of the insulin receptor in cultured fibroblasts from patients with lipoatropic diabetes.
Topics: Adolescent; Adult; Autoradiography; Binding Sites; Binding, Competitive; Cells, Cultured; Child; Child, Preschool; Chromatography, Affinity; Diabetes Mellitus, Lipoatrophic; Female; Humans; Infant; Insulin Resistance; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Cell Surface; Receptors, Somatomedin; Serine; Tyrosine | 1989 |
Transformation by Rous sarcoma virus induces clathrin heavy chain phosphorylation.
Topics: Animals; Avian Sarcoma Viruses; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Clathrin; Fibroblasts; Fluorescent Antibody Technique; Phosphorylation; Precipitin Tests; Serine; Tyrosine | 1989 |
Efficient expression in insect cells of a soluble, active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; Gene Expression Regulation; Insect Viruses; Lepidoptera; Molecular Weight; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Serine; Transfection; Tyrosine | 1988 |
Splanchnic substrate balance in malnourished patients during parenteral nutrition.
Topics: Adipose Tissue; Alanine; Amino Acids, Branched-Chain; Cystine; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucose; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Lipids; Liver; Male; Mesentery; Nitrogen; Parenteral Nutrition; Parenteral Nutrition, Total; Protein Biosynthesis; Protein-Energy Malnutrition; Serine; Splanchnic Circulation; Threonine; Tyrosine | 1985 |
Phosphorylation of protein tyrosine by human erythrocyte casein kinase A.
Topics: Angiotensin II; Ankyrins; Casein Kinases; Erythrocytes; Humans; Isoenzymes; Membrane Proteins; Peptides; Phosphorylation; Protein Kinases; Serine; Threonine; Tyrosine | 1986 |
Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies.
Topics: Annexins; Antibodies, Monoclonal; Cell Transformation, Viral; Epidermal Growth Factor; Humans; Membrane Proteins; Oncogene Protein pp60(v-src); Oncogenes; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Retroviridae Proteins; Serine; Tyrosine | 1986 |
Structure-activity relationships of atrial natriuretic factor (ANF). III. Correlation of receptor affinity with relative potency on aldosterone production in zona glomerulosa cells.
Topics: Adrenal Cortex; Aldosterone; Alprostadil; Animals; Atrial Natriuretic Factor; Binding, Competitive; Biological Assay; Cattle; Dose-Response Relationship, Drug; Peptide Fragments; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Serine; Structure-Activity Relationship; Tyrosine | 1985 |
Yeast cytochrome c with phenylalanine or tyrosine at position 87 transfers electrons to (zinc cytochrome c peroxidase)+ at a rate ten thousand times that of the serine-87 or glycine-87 variants.
Topics: Cytochrome c Group; Cytochrome-c Peroxidase; Electron Transport; Genetic Variation; Glycine; History, Ancient; Mutation; Peroxidases; Phenylalanine; Saccharomyces cerevisiae; Serine; Structure-Activity Relationship; Tyrosine | 1987 |
Activation of transforming potential of the human insulin receptor gene.
Topics: Animals; Avian Sarcoma Viruses; Base Sequence; Cell Transformation, Viral; Chick Embryo; Cytopathogenic Effect, Viral; DNA; DNA, Viral; Fibroblasts; Glucose; Glycosylation; Humans; Phosphorylation; Receptor, Insulin; Serine; Transfection; Tyrosine | 1987 |
Regulation of the protein kinase activity of the human insulin receptor.
Topics: Enzyme Activation; Insulin; Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Serine; Threonine; Tyrosine | 1987 |
Sequential metabolic characteristics following portacaval shunt in rats.
Topics: Amino Acids; Animals; Body Weight; Glucagon; Insulin; Isoleucine; Leucine; Male; Phenylalanine; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1986 |
Mitogen treatment of permeabilized human T lymphocytes stimulates rapid tyrosine and serine phosphorylation of a 42 kDa protein.
Topics: Antibodies, Monoclonal; Cell Membrane Permeability; Humans; Mitogens; Phosphoproteins; Phosphorylation; Phytohemagglutinins; Serine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Identification and assay of phosphoserine and tyrosine-O-sulphate in fibrinopeptides by reversed-phase high-performance liquid chromatography.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Fibrinogen; Fibrinopeptide A; Fibrinopeptide B; Hydrolysis; Phosphates; Phosphoserine; Serine; Tyrosine | 1986 |
A model study directed towards the preparation of nucleopeptides via H-phosphonate intermediates.
Topics: Indicators and Reagents; Magnetic Resonance Spectroscopy; Nucleoproteins; Organophosphonates; Peptide Fragments; Serine; Structure-Activity Relationship; Threonine; Tyrosine | 1987 |
Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Endothelium; Insulin; Phosphorylation; Rats; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Trypsin; Tyrosine | 1987 |
Epidermal growth factor stimulates tyrosine phosphorylation of human glucocorticoid receptor in cultured cells.
Topics: Breast; Cell Line; Dexamethasone; Epidermal Growth Factor; Female; Humans; Phosphorylation; Receptors, Glucocorticoid; Serine; Tyrosine | 1987 |
Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virus.
Topics: Alpharetrovirus; Animals; Avian Leukosis; Chickens; Coturnix; Gene Expression Regulation; Oncogene Protein pp60(v-src); Oncogenes; Peptide Mapping; Phosphorylation; Protein-Tyrosine Kinases; Rats; Retroviridae Proteins; Serine; Tyrosine | 1987 |
Increase in norepinephrine turnover after tyrosine or DL-threo-3,4-dihydroxyphenylserine (DL-threo-DOPS).
Topics: Animals; Benzylamines; Brain; Droxidopa; Male; Methoxyhydroxyphenylglycol; Mice; Norepinephrine; Serine; Tyrosine | 1988 |
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Chromatography, Affinity; Insulin; Liver Neoplasms, Experimental; Phosphorylation; Phosphoserine; Phosphothreonine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1988 |
The growth cone cytoskeleton. Glycoprotein association, calmodulin binding, and tyrosine/serine phosphorylation of tubulin.
Topics: Animals; Animals, Newborn; Brain; Calmodulin; Cytoskeleton; Glycoproteins; Kinetics; Microscopy, Electron; Molecular Weight; Phosphorylation; Protein Kinases; Rats; Serine; Tubulin; Tyrosine | 1988 |
Water solubilization of membrane proteins. Extensive derivatization with a novel polar derivatizing reagent.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Indicators and Reagents; Kinetics; Membrane Proteins; Models, Chemical; Serine; Solubility; Solvents; Threonine; Tyrosine; Water | 1988 |
Nonenzymatic phosphorylation of tyrosine and serine by ATP is catalyzed by manganese but not magnesium.
Topics: Adenosine Triphosphate; Animals; Hot Temperature; Hydrogen-Ion Concentration; Intercellular Signaling Peptides and Proteins; Magnesium; Manganese; Peptides; Phosphopyruvate Hydratase; Phosphorylation; Rabbits; Serine; Temperature; Tyrosine | 1988 |
The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.
Topics: Animals; Hybridomas; Macromolecular Substances; Molecular Weight; Phosphorylation; Receptors, Antigen, T-Cell; Serine; T-Lymphocytes; Tyrosine | 1988 |
Irreversible inhibition of pancreatic lipase by bis-p-nitrophenyl methylphosphonate.
Topics: Animals; Binding Sites; Kinetics; Lipase; Organophosphorus Compounds; Pancreas; Serine; Swine; Tyrosine | 1985 |
Analysis of the factors and implications of an empirical method for estimating the stability of mutant human haemoglobins.
Topics: Amino Acid Sequence; Glycine; Hemoglobins; Humans; Macromolecular Substances; Monte Carlo Method; Mutation; Probability; Protein Conformation; Serine; Tryptophan; Tyrosine | 1985 |
Corticosteroid induced changes in plasma amino acids and thyroid activity in dairy cows treated early or late during lactation.
Topics: Adrenal Cortex Hormones; Amino Acids; Animals; Body Weight; Cattle; Dexamethasone; Female; Flumethasone; Glutamine; Glycerol; Iodine; Isoleucine; Lactation; Methionine; Phenylalanine; Pregnancy; Serine; Thyroid Function Tests; Thyroid Gland; Tyrosine; Urea; Valine | 1971 |
Immunological studies on the major haptenic peptides from performic acid oxidized ferredoxin from Clostridium pasteurianum.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Antibody Formation; Antigens; Aspartic Acid; Binding Sites; Carbon Isotopes; Clostridium; Complement Fixation Tests; Complement System Proteins; Dialysis; Electrophoresis; Epitopes; Ferredoxins; Formates; Glutamates; Glutamine; Haptens; Immune Sera; Immunoglobulin G; Isoleucine; Lysine; Oxidation-Reduction; Peptides; Proline; Rabbits; Serine; Tyrosine; Valine | 1971 |
Peptides from the site of rabbit antibody: anti-3-azopyridine antibody.
Topics: Amino Acid Sequence; Animals; Antibodies; Antigen-Antibody Reactions; Autoanalysis; Autoradiography; Azo Compounds; Binding Sites; Cattle; Chromatography; Electrophoresis, Paper; gamma-Globulins; Haptens; Immunochemistry; Iodine Isotopes; Isoelectric Focusing; Leucine; Pepsin A; Peptides; Pyridines; Rabbits; Serine; Tyrosine | 1971 |
Studies on the enzymes involved in the biosynthesis of cyclo-tris (N-2,3-dihydroxybenzoyl-L-seryl) in Escherichia coli: kinetic properties of the L-serine-activating enzyme.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Anti-Bacterial Agents; Drug Stability; Enzyme Induction; Escherichia coli; Ethylmaleimide; Glycine; Gramicidin; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Phosphates; Phosphorus Radioisotopes; Proline; Serine; Threonine; Time Factors; Tritium; Tyrosine | 1973 |
Radiochemical determination of the optical purity of L-amino acids.
Topics: Alanine; Amino Acids; Aspartic Acid; Carbon Radioisotopes; Catalase; D-Amino-Acid Oxidase; Hydrogen-Ion Concentration; Isoleucine; Kinetics; Leucine; Methionine; Phenylalanine; Selenium; Serine; Stereoisomerism; Tritium; Tyrosine; Valine | 1974 |
[Relation between gamma-aminobutyric acid and tyrosine metabolism and changes in the brain and liver amino acid content in intact and adrenalectomized rats].
Topics: Adrenal Glands; Adrenalectomy; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamine; Glycine; Liver; Lysine; Male; Rats; Serine; Stimulation, Chemical; Threonine; Tyrosine | 1972 |
Comparison of the amino acid sequences of the variable regions of light chains derived from two homogeneous rabbit anti-pneumococcal antibodies.
Topics: Aconitic Acid; Alanine; Amino Acid Sequence; Amino Acids; Animals; Antibodies, Bacterial; Asparagine; Aspartic Acid; Autoanalysis; Chromatography, Gel; Electrophoresis, Paper; Glutamates; Glycine; Hydrolysis; Immunoglobulin Fragments; Rabbits; Serine; Streptococcus pneumoniae; Threonine; Tyrosine; Valine | 1974 |
[Complete aminco acid sequence of Bence Jones portein Kern. A new subgroup of the immunoglobulin L-chains of lambda-type].
Topics: Amino Acid Sequence; Bence Jones Protein; Carboxypeptidases; Chromatography, Ion Exchange; gamma-Globulins; Glycine; Peptides; Serine; Tyrosine | 1968 |
Argininosuccinic aciduria in hereditary hair diseases.
Topics: Adolescent; Adult; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Child, Preschool; Chromatography, Paper; Cystinuria; Female; Glutamates; Glutamine; Glycine; Hair; Histidine; Humans; Infant; Lysine; Male; Middle Aged; Serine; Skin Diseases; Threonine; Tyrosine; Valine | 1968 |
D-amino acids in the cell pool of bacteria.
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Bacillus subtilis; Bacteria; Chromatography, Thin Layer; Clostridium; Culture Media; Escherichia coli; Glutamates; Histidine; Hydrogen-Ion Concentration; Lactobacillus; Leucine; Proline; Serine; Spectrophotometry; Staphylococcus; Stereoisomerism; Temperature; Tyrosine | 1974 |
[Influence of changes in urinary pH on the excretion of amino acids from the isolated perfused rat kidney].
Topics: Alanine; Amino Acids; Animals; Arginine; Diffusion; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Leucine; Lysine; Perfusion; Rats; Serine; Threonine; Tyrosine; Urine; Valine | 1967 |
The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo.
Topics: 5-Hydroxytryptophan; Acetamides; Animals; Benzyl Compounds; Brain; Carboxy-Lyases; Dimethylamines; Dose-Response Relationship, Drug; Feedback; Female; Fenclonine; Hydrazines; Hydroxyindoleacetic Acid; Lysergic Acid Diethylamide; Mice; Nialamide; Phenylalanine; Reserpine; Sensory Receptor Cells; Serine; Serotonin; Tryptamines; Tryptophan; Tryptophan Hydroxylase; Tyrosine | 1972 |
O-sulfate esters of hydroxy amino acids in hydrolyzates of proteoglycans.
Topics: Amino Acids; Animals; Cartilage; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Esters; Glycosaminoglycans; Hydrochloric Acid; Hydrolysis; Hydroxyproline; Methods; Potassium; Serine; Sulfates; Sulfuric Acids; Threonine; Tyrosine | 1972 |
Cystathioninuria.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carcinoma, Hepatocellular; Child, Preschool; Cysteine; Diet Therapy; Female; Galactosemias; Glycogen; Humans; Infant; Intellectual Disability; Liver Neoplasms; Male; Maple Syrup Urine Disease; Methionine; Middle Aged; Neuroblastoma; Phenylketonurias; Portal Vein; Pyridoxine; Serine; Sulfisoxazole; Tyrosine | 1967 |
The role of anticodon in the acceptor function of tRNA.
Topics: Alkaline Phosphatase; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Genetic Code; Genetics, Microbial; Molecular Biology; Nucleotides; Periodic Acid; RNA, Transfer; Saccharomyces; Serine; Tyrosine; Valine | 1969 |
Electron paramagnetic resonance study of free radical products of the reaction of ninhydrin with amino acids, peptides and proteins.
Topics: Alanine; Amino Acids; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Dipeptides; Electron Spin Resonance Spectroscopy; Ethanol; Free Radicals; Histidine; Hydrogen-Ion Concentration; Indicators and Reagents; Lysine; Peptides; Phenylalanine; Proline; Proteins; Serine; Solutions; Tryptophan; Tyrosine; Valine | 1970 |
Isolation of amino acid acceptor RNA from purified avian myeloblastosis virus.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Avian Leukosis Virus; Centrifugation, Density Gradient; Chick Embryo; Glycine; In Vitro Techniques; Isoleucine; Ligases; Methionine; Phenylalanine; Proline; Ribonucleases; RNA, Transfer; RNA, Viral; Serine; Threonine; Tritium; Tyrosine; Valine | 1970 |
Transfer RNA modifications and synthesis in animal cells.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Differentiation; Chickens; Chromatography; Chromatography, Ion Exchange; Echinodermata; Electrophoresis; Epithelium; Female; Fibroblasts; Leukocytes; Liver; Liver Neoplasms; Molecular Biology; Neoplasms, Experimental; Ovum; Rabbits; Rats; RNA, Neoplasm; RNA, Transfer; Serine; Tritium; Tyrosine | 1971 |
Alterations of free amino acids concentrations in cat brain induced by rapid eye movement sleep deprivation.
Topics: Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Brain; Cats; Caudate Nucleus; Cysteine; Frontal Lobe; Glutamates; Glycine; Hippocampus; Histidine; Lysine; Male; Occipital Lobe; Reticular Formation; Serine; Sleep Deprivation; Sleep, REM; Thalamus; Threonine; Tyrosine | 1971 |
Alterations in the transfer RNA population of hepatoma 9618A as compared with normal rat liver.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Histidine; Leucine; Liver; Liver Neoplasms; Lysine; Male; Neoplasms, Experimental; Phenylalanine; Rats; RNA, Neoplasm; RNA, Transfer; Serine; Tritium; Tyrosine | 1971 |
Partial degradation of transfer RNAs and transfer RNA fragments by spleen phosphodiesterase as studied by disc electrophoretic methods.
Topics: Animals; Base Sequence; Chemical Phenomena; Chemistry; Densitometry; Electrophoresis, Disc; Escherichia coli; Kinetics; Methods; Oligonucleotides; Phenylalanine; Phosphoric Acids; Phosphoric Diester Hydrolases; RNA, Bacterial; RNA, Transfer; Serine; Spleen; Swine; Tyrosine | 1972 |
Partial degradation of transfer RNAs by sheep kidney nuclease.
Topics: Adenine Nucleotides; Alkaline Phosphatase; Animals; Coliphages; Cytosine Nucleotides; Electrophoresis, Disc; Escherichia coli; Kidney; Kinetics; Magnesium; Oligonucleotides; Phenylalanine; Phosphoric Diester Hydrolases; Polynucleotides; Ribonucleases; RNA, Transfer; Saccharomyces cerevisiae; Serine; Sheep; Snakes; Tyrosine; Uracil Nucleotides; Valine; Venoms | 1972 |
A study of the action of peptides with corticotrophic activity on isolated adrenal cells.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; In Vitro Techniques; Lysine; Rats; Serine; Tyrosine | 1972 |
Confirmation of UAG as a nonsense codon in bakers' yeast by amino acid replacements of glutamic acid 71 in iso-1-cytochrome c.
Topics: Adenine; Amino Acid Sequence; Amino Acids; Chromatography; Cytochrome c Group; Electrophoresis; Genetic Code; Glutamates; Guanine; Leucine; Lysine; Peptide Chain Termination, Translational; Saccharomyces cerevisiae; Serine; Tryptophan; Tyrosine; Uracil | 1973 |
Radical yield in X-irradiated biological molecules. II. Naturally-occurring amino-acids.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamates; Histamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Transfer RNA genes in mitochondrial DNA of grande (wild-type) yeast.
Topics: Amino Acyl-tRNA Synthetases; Aspartic Acid; Chromatography; Cytoplasm; Cytosol; DNA, Mitochondrial; Escherichia coli; Genes; Glutamates; Histidine; Hot Temperature; Kinetics; Lysine; Mitochondria; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Proline; RNA, Transfer; Saccharomyces cerevisiae; Serine; Silicon Dioxide; Tritium; Tyrosine | 1974 |
Effects of casein hydrolysate on the induction and regulation of tyrosine-alpha-ketoglutarate transaminase in rat liver.
Topics: Adrenal Glands; Adrenalectomy; Animals; Carbon Isotopes; Caseins; Cycloheximide; Dactinomycin; Dietary Proteins; Drug Synergism; Enzyme Induction; Hydro-Lyases; Hydrocortisone; Liver; Orotic Acid; Peroxidases; Protein Biosynthesis; Rats; RNA; Serine; Time Factors; Tryptophan; Tryptophan Oxygenase; Tyrosine; Tyrosine Transaminase | 1968 |
Mutant strains of Escherichia coli K12 that use D-amino acids.
Topics: Amino Acids; Arginine; Chromosome Mapping; Coliphages; D-Amino-Acid Oxidase; Escherichia coli; Genetic Linkage; Genotype; Histidine; Isoleucine; Isomerism; Leucine; Lysine; Mutation; Phenylalanine; Proline; Serine; Threonine; Transduction, Genetic; Tryptophan; Tyrosine; Valine | 1971 |
Lipolytic and hypoglycemic compounds obtained from cystoseira barbata J. Ag.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Autoanalysis; Blood Glucose; Chromatography, Gel; Chromatography, Paper; Eukaryota; Glutamine; Histidine; Leucine; Lipid Metabolism; Lysine; Methionine; Peptide Fragments; Rabbits; Rats; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Feto-maternal amino acid metabolism.
Topics: Amino Acids; Amniocentesis; Amniotic Fluid; Arginine; Autoanalysis; Carnosine; Ethanolamines; Female; Fetus; Gestational Age; Glycine; Humans; Hydroxyproline; Infant, Newborn; Lysine; Maternal-Fetal Exchange; Phenylalanine; Pregnancy; Serine; Tyrosine; Umbilical Cord | 1974 |
TMV coat protein synthesis in vivo: analysis of the N-terminal acetylation.
Topics: Acetylation; Amino Acids; Carbon Radioisotopes; Chromatography, Paper; Chymotrypsin; Dipeptides; Nicotiana; Peptide Biosynthesis; Peptide Chain Termination, Translational; Peptide Fragments; Peptides; Plants, Toxic; RNA, Transfer; RNA, Viral; Serine; Tobacco Mosaic Virus; Tritium; Trypsin; Tyrosine; Viral Proteins | 1974 |
Plasma concentrations of tryptophan and other amino acids in manic-depressive patients.
Topics: Alanine; Arginine; Aspartic Acid; Bipolar Disorder; Emotions; Glutamates; Glycine; Humans; Isoleucine; Leucine; Methionine; Psychology; Serine; Threonine; Tryptophan; Tyrosine | 1974 |
[Amino acid levels in the blood serum of patients with chronic colitis].
Topics: Adult; Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Betaine; Chronic Disease; Citrulline; Colitis; Glutamates; Glutamine; Glycine; Histidine; Humans; Middle Aged; Ornithine; Phenylalanine; Proline; Serine; Taurine; Threonine; Tryptophan; Tyrosine; Urea | 1974 |
[Free amino acids in the 24 h urine of healthy children (author's transl)].
Topics: Adolescent; Age Factors; Alanine; Amino Acids; Aminobutyrates; Carnosine; Child; Chromatography, Ion Exchange; Citrulline; Female; Glycine; Histidine; Humans; Isoleucine; Lysine; Male; Methionine; Ornithine; Phenylalanine; Serine; Sex Factors; Threonine; Tyrosine; Valine | 1974 |
L-dihydroxyphenylalanine: effect on levels of free amino acids in rat liver.
Topics: Amino Acids; Animals; Aspartic Acid; Dihydroxyphenylalanine; Glutamates; Isoleucine; Liver; Male; Methionine; Organ Size; Rats; Serine; Threonine; Tyrosine | 1974 |
Free amino acids in the haemocytes and plasma of the larva of Calliphora vicina.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Blood Cells; Blood Coagulation; Diptera; Glutamates; Glutamine; Glycine; Hemolymph; Histidine; Isoleucine; Larva; Leucine; Lysine; Methionine; Phenylalanine; Plasma; Proline; Serine; Taurine; Threonine; Tyrosine; Valine | 1974 |
Study of serum amino acids in Egyptian lead workers.
Topics: Adult; Alanine; Amino Acids; Colorimetry; Egypt; Glutamates; Glycine; Histidine; Humans; Lead Poisoning; Leucine; Lysine; Male; Middle Aged; Proline; Serine; Tyrosine; Valine | 1974 |
Studies on the fractionation of total transfer ribonucleic acid and purification of an alanine transfer ribonucleic acid from chick embryo.
Topics: Alanine; Animals; Aspartic Acid; Chemical Fractionation; Chick Embryo; Chromatography, Ion Exchange; Histidine; Isoleucine; Lysine; Proline; Ribonucleases; RNA, Transfer; Serine; Tyrosine; Valine | 1974 |
Comparative study of some conformational properties of alpha, beta and psi bovine trypsins.
Topics: Animals; Aspartic Acid; Benzamidines; Binding, Competitive; Cattle; Hydrogen-Ion Concentration; Kinetics; Lysine; Optical Rotatory Dispersion; Protein Conformation; Serine; Spectrophotometry; Trypsin; Tyrosine | 1974 |
Self purification of two serine endopeptidases.
Topics: Catalysis; Chromatography, Gel; Chromatography, Ion Exchange; Dansyl Compounds; Electrophoresis, Disc; Endopeptidases; Ethanol; Guanidines; Isoflurophate; Isoleucine; Peptide Hydrolases; Phosphorus Isotopes; Pronase; Protein Conformation; Serine; Tyrosine | 1972 |
Fluorescence studies on substrate binding to seryl-tRNA synthetase from yeast.
Topics: Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Binding Sites; Cytosine Nucleotides; Kinetics; Methods; Phenylalanine; RNA, Transfer; Saccharomyces cerevisiae; Serine; Spectrometry, Fluorescence; Structure-Activity Relationship; Tryptophan; Tyrosine | 1972 |
Large scale purification of tRNA ser , tRNA tyr and tRNA phe from Baker's yeast.
Topics: Acylation; Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Chelating Agents; Chromatography, Ion Exchange; Cytosine Nucleotides; Electrophoresis, Polyacrylamide Gel; Nucleotidyltransferases; Phenylalanine; RNA, Transfer; Saccharomyces cerevisiae; Serine; Tyrosine; Urea | 1972 |
Kinetics of the reaction of nitrous acid with model compounds and proteins, and the conformational state of N-terminal groups in the chymotrypsin family.
Topics: Amines; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Esters; Hydrogen-Ion Concentration; Indoleacetic Acids; Isoleucine; Kinetics; Nitrites; Nitroso Compounds; Osmolar Concentration; Pancreatic Elastase; Pepsin A; Peptides; Protein Conformation; Proteins; Serine; Spectrophotometry, Ultraviolet; Swine; Trypsin; Tryptophan; Tyrosine | 1972 |
In vivo translation of amber and ochre codons in Escherichia coli.
Topics: Autoradiography; Escherichia coli; Genetic Code; Genetics, Microbial; Iron; Methionine; Nucleotides; Protein Biosynthesis; Resins, Plant; RNA, Bacterial; RNA, Messenger; Serine; Suppression, Genetic; Tyrosine | 1973 |
Structure of a hypothalamic peptide possessing gonadotropin-releasing activity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Carbon Isotopes; Glutamates; Glycine; Gonadotropins; Histidine; Hypothalamus; Leucine; Mass Spectrometry; Peptide Chain Termination, Translational; Pituitary Hormone-Releasing Hormones; Proline; Serine; Swine; Tryptophan; Tyrosine | 1972 |
5S rRNA and t RNA: evidence for a common evolutionary origin.
Topics: Animals; Aspartic Acid; Base Sequence; Biological Evolution; Escherichia coli; Genetic Code; Glutamine; Models, Biological; Nucleotides; Phenylalanine; Rats; RNA, Ribosomal; RNA, Transfer; Saccharomyces cerevisiae; Serine; Triticum; Tyrosine | 1973 |
High-resolution NMR investigation of base pairing structure of transfer RNA.
Topics: Arginine; Base Sequence; Binding Sites; Chromatography, Gel; Escherichia coli; Glutamates; Hot Temperature; Magnetic Resonance Spectroscopy; Methionine; Nucleic Acid Conformation; Oligonucleotides; Phenylalanine; Ribonucleases; RNA, Bacterial; RNA, Transfer; Saccharomyces cerevisiae; Serine; Species Specificity; Tryptophan; Tyrosine | 1973 |
Unfolding of yeast transfer ribonucleic acid species caused by addition of organic solvents and studied by circular dichroism.
Topics: Arsenicals; Buffers; Circular Dichroism; Crystallization; Dioxins; Ethanol; Glycols; Hexanols; Isoleucine; Magnesium; Nucleic Acid Conformation; Nucleic Acid Denaturation; Phenylalanine; RNA, Transfer; Saccharomyces cerevisiae; Serine; Sodium Chloride; Spectrophotometry, Ultraviolet; Spermidine; Spermine; Temperature; Tyrosine; Urea; Valine | 1974 |
Modification of transfer ribonucleic acid by an alkylating fragment from S-(1,2-dichlorovinyl)-L-cysteine.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Cysteine; Escherichia coli; Histidine; Liver; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Serine; Species Specificity; Spectrophotometry, Ultraviolet; Sulfur Radioisotopes; Transfer RNA Aminoacylation; Tyrosine; Vinyl Compounds | 1974 |
Nucleotide sequences of transfer ribonucleic acids.
Topics: Alanine; Arginine; Aspartic Acid; Base Sequence; Biological Evolution; Escherichia coli; Evaluation Studies as Topic; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Plants; RNA, Bacterial; RNA, Transfer; Saccharomyces cerevisiae; Serine; Species Specificity; Tryptophan; Tyrosine; Valine | 1974 |
Isoacceptor tRNA species.
Topics: Animals; Anticodon; Base Sequence; Chickens; Coliphages; DNA Viruses; Drosophila; Escherichia coli; Estrogens; Histidine; Leucine; Liver; Mutation; Phosphoproteins; Rats; Ribonucleotides; RNA, Transfer; Salmonella typhimurium; Serine; Tyrosine | 1973 |
A trial of Ro 4-2137 in the treatment of hypertension.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Synergism; Drug Tolerance; Female; Humans; Hypertension; Male; Methyl Ethers; Middle Aged; Phenols; Serine; Time Factors; Tyrosine | 1972 |
Regulation of glyconeogenesis from amino acids by acetate in Tetrahymena pyriformis.
Topics: Acetates; Alanine; Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Carbon Isotopes; Cells, Cultured; Culture Media; Glucose; Glutamates; Glycogen; Isoleucine; Leucine; Serine; Tetrahymena pyriformis; Time Factors; Tyrosine | 1973 |
[Blood-brain barrier and placental barrier for various amino acids in the mouse (whole body autoradiography studies)].
Topics: Alanine; Amino Acids; Animals; Autoradiography; Blood-Brain Barrier; Cell Membrane Permeability; Female; Glycine; Lysine; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Phenylalanine; Pregnancy; Serine; Tritium; Tyrosine | 1972 |
Amino acids and peptides. 34. Synthesis of a structure related to scotophobin.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Glutamine; Glycine; Lysine; Memory; Peptides; Serine; Tyrosine | 1972 |
Amino acid compositions of all the tryptic peptides from the and polypeptide chains of adult hemoglobin of the slow loris (Nycticebus coucang). Biochemical studies on hemoglobins and myoglobins. X.
Topics: Alanine; Amino Acids; Animals; Arginine; Chromatography; Chromatography, Paper; Glutamine; Hemoglobins; Histidine; Isoleucine; Leucine; Lysine; Methionine; Myoglobin; Peptides; Phenylalanine; Primates; Serine; Threonine; Trypsin; Tyrosine; Valine | 1972 |
[Amino acid metabolism pathology in the convulsive syndrome in young children].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Child, Preschool; Cystine; Female; Glutamates; Glutamine; Glycine; Histidine; Humans; Infant; Infant, Newborn; Leucine; Lysine; Male; Methionine; Proline; Seizures; Serine; Tryptophan; Tyrosine; Valine | 1972 |
[Biologically inactive tRNA of the liver in young rats].
Topics: Activation Analysis; Acylation; Age Factors; Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chemistry, Organic; Liver; Lysine; Male; Methionine; Methods; Organic Chemistry Phenomena; Rats; RNA, Transfer; Serine; Sulfur Isotopes; Tyrosine | 1972 |
[Specificity of the interaction of tRNA and amino acyl tRNA synthetase in rats of different ages].
Topics: Acylation; Age Factors; Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chromatography, DEAE-Cellulose; Liver; Lysine; Methionine; Molecular Conformation; Rats; RNA, Transfer; Serine; Sulfur Isotopes; Tyrosine | 1972 |
Effect of other amino acids on recovery of tryptophan following acid hydrolysis.
Topics: Amino Acids; Chromatography, Ion Exchange; Colorimetry; Cystine; Hydrochloric Acid; Hydrolysis; Hydroxyproline; Proteins; Serine; Tryptophan; Tyrosine | 1973 |
The reversal of triparanol-induced cataracts in the rat. 3. Amino acid content and uptake of 14 C -AIB in cataractous and clearing lenses.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Cataract; Cystine; Diet; Glutamates; Glycine; Histidine; Isoleucine; Lens, Crystalline; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rats; Serine; Threonine; Triparanol; Tyrosine; Valine | 1973 |
Modifications of serum-free amino acid patterns of Babinga adult pygmies after short-term feeding of a balanced diet.
Topics: Adolescent; Adult; Alanine; Amino Acids; Anti-Infective Agents; Black People; Central African Republic; Diet; Dietary Fats; Dietary Proteins; Feeding Behavior; Glutamates; Glycine; Humans; Intestinal Diseases; Male; Nutritional Physiological Phenomena; Phenylalanine; Protein Deficiency; Serine; Time Factors; Tyrosine; Vitamins | 1973 |
Amino acid levels in plasma, liver, and skeletal muscle during protein deprivation.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Body Weight; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Liver; Male; Methionine; Muscles; Organ Size; Phenylalanine; Protein Deficiency; Rats; Serine; Threonine; Time Factors; Tyrosine; Valine | 1973 |
The isolation and properties of a tyrosine-rich protein from wool: component 0.62.
Topics: Animals; Autoanalysis; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Circular Dichroism; Electrophoresis, Starch Gel; Glycine; Hydrogen-Ion Concentration; Isoelectric Focusing; Keratins; Molecular Weight; Phenylalanine; Serine; Sheep; Solubility; Tryptophan; Tyrosine; Ultracentrifugation; Wool | 1973 |
Alterations in renal and plasma amino acid concentrations during renal compensatory growth.
Topics: Alanine; Amino Acids; Animals; Kidney; Kidney Cortex; Leucine; Male; Methionine; Nephrectomy; Ornithine; Rats; Serine; Starvation; Threonine; Tyrosine | 1973 |
Variability in the tertiary structure of alpha-chymotrypsin at 2.8-A resolution.
Topics: Amino Acid Sequence; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Electrons; Gold; Hydrogen-Ion Concentration; Macromolecular Substances; Mercury; Models, Structural; Platinum; Protein Conformation; Selenium; Serine; Sulfates; Tyrosine; Uranium; X-Ray Diffraction | 1973 |
Changes in the tertiary structure of alpha-chymotrypsin with change in pH: p4 4.2-6.7.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Chymotrypsin; Histidine; Hydrogen-Ion Concentration; Macromolecular Substances; Methionine; Models, Structural; Phenylalanine; Protein Binding; Protein Conformation; Serine; Tyrosine; Uranium; X-Ray Diffraction | 1973 |
Chromatography of plant aminoacyl-tRNA synthetases on omega-aminoalkyl sepharose columns.
Topics: Amines; Amino Acyl-tRNA Synthetases; Butylamines; Carbon Radioisotopes; Chromatography, Affinity; Ethylamines; Hydrogen-Ion Concentration; Molecular Weight; Phenylalanine; Plants; Polysaccharides; Seeds; Serine; Spectrophotometry, Ultraviolet; Tritium; Tryptophan; Tyrosine; Valine | 1973 |
The metabolism of amino acids in the bovine lens. Their oxidation as a source of energy.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Carbon Dioxide; Carbon Radioisotopes; Cattle; Collagen; Energy Metabolism; Glucose; Glutamates; Glutathione; In Vitro Techniques; Lactates; Lens, Crystalline; Leucine; Lipid Metabolism; Lysine; Oxidation-Reduction; Proline; Serine; Taurine; Tryptophan; Tyrosine | 1973 |
Free amino acids in E.L.4 mouse ascites tumor cells taken from susceptible (C57BL) and resistant (B10.D2) mice.
Topics: Alanine; Amino Acids; Animals; Arginine; Cell Line; Computers; Depression, Chemical; Glycine; Histidine; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neoplasms, Experimental; Serine; Species Specificity; Time Factors; Tyrosine | 1973 |
Functional and modulatory adaptation of tRNA in the silk gland of bombyx mori L. to fibroin biosynthesis.
Topics: Alanine; Amino Acids; Animals; Bombyx; Fibroins; Genetic Code; Glycine; Metamorphosis, Biological; Protein Biosynthesis; RNA, Messenger; RNA, Transfer; Serine; Tyrosine | 1973 |
Synthesis and catalytic properties of the heptapeptide L-seryl-L-prolyl-L-cysteinyl-L-steryl-alpha-L-glutamyl-L-threonyl-L-tyrosine.
Topics: Acetates; Carboxypeptidases; Chromatography, Gel; Chromatography, Thin Layer; Cysteine; Dicyclohexylcarbodiimide; Esters; Glutamates; Hydrogen-Ion Concentration; Kinetics; Mathematics; Nitrophenols; Oligopeptides; Optical Rotation; Proline; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Threonine; Tyrosine | 1974 |
Selective malabsorption of vitamin B 12: report of a case with metabolic studies.
Topics: Alanine; Amino Acids; Anemia, Macrocytic; Child; Chromatography, Gas; Glycine; Hemoglobins; Histidine; Humans; Isoleucine; Leucine; Malabsorption Syndromes; Male; Malonates; Methionine; Proteinuria; Renal Tubular Transport, Inborn Errors; Reticulocytes; Serine; Taurine; Threonine; Tyrosine; Valine; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Intracellular free amino acid concentration in human muscle tissue.
Topics: Adult; Alanine; Amino Acids; Arginine; Asparagine; Biopsy, Needle; Body Water; Chlorides; Citrulline; Extracellular Space; Female; Glutamates; Glutamine; Glycine; Histidine; Humans; Isoleucine; Leucine; Lipid Metabolism; Male; Muscles; Ornithine; Phenylalanine; Proline; Serine; Taurine; Tyrosine; Valine | 1974 |
Luteinizing hormone. 2. Relative reactivities of tyrosyl residues of the porcine hormone towards iodination.
Topics: Amino Acid Sequence; Animals; Binding Sites; Carboxypeptidases; Chromatography, Gel; Circular Dichroism; Hydrogen Peroxide; Iodine; Luteinizing Hormone; Lysine; Macromolecular Substances; Molecular Conformation; Peptide Fragments; Peroxidases; Serine; Swine; Trypsin; Tyrosine | 1974 |
Biosynthesis of edeine. Fractionation and characterization of enzymes responsible for biosynthesis of edeine A and B.
Topics: Aminoacylation; Anti-Bacterial Agents; Bacillus; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Glycine; Guanine; Hydrogen-Ion Concentration; Isoelectric Focusing; Kinetics; Molecular Weight; Peptide Biosynthesis; Phosphorus Radioisotopes; Polyamines; Propionates; Serine; Spermidine; Time Factors; Tritium; Tyrosine | 1974 |
[Synthesis routes of the principal amino acids of silk in the silk gland of the silkworm].
Topics: Alanine; Alanine Transaminase; Aldehyde-Lyases; Amino Acids; Aspartate Aminotransferases; Bombyx; Carboxy-Lyases; Electrophoresis, Polyacrylamide Gel; Fibroins; Glycine; Serine; Transferases; Tyrosine | 1974 |
Highly restricted specificity of the serine proteinase aspergillopeptidase B.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspergillus; Cattle; Chromatography, Ion Exchange; Evaluation Studies as Topic; Glutamates; Hydrogen-Ion Concentration; Insulin; Kinetics; Leucine; Methods; Oxidation-Reduction; Peptide Fragments; Peptide Hydrolases; Serine; Spectrophotometry, Ultraviolet; Time Factors; Tyrosine; Zinc | 1974 |
Hydroxymethylation of the benzene ring. 3. Synthesis of the D- and L-isomers of p-hydroxymethylphenylalanine and the biochemical properties of the L-isomer.
Topics: Acetates; Amides; Amines; Benzene Derivatives; Escherichia coli; Glutamates; Infrared Rays; Magnetic Resonance Spectroscopy; Malonates; Methanol; Methods; Methylation; Optical Rotatory Dispersion; Phenylalanine; Serine; Spectrum Analysis; Tyrosine; Ultraviolet Rays | 1967 |
Comparative studies on specific and nonspecific binding of transfer ribonucleic acid to ribosomes.
Topics: Carbon Isotopes; Escherichia coli; Leucine; Lysine; Magnesium; Methionine; Phenylalanine; Ribosomes; RNA, Messenger; RNA, Transfer; Serine; Tetracycline; Tritium; Trypsin; Tyrosine; Uracil Nucleotides | 1968 |
Fractionation of Escherichia coli transfer RNA on benzoylated DEAE-cellulose.
Topics: Benzoates; Cellulose; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Escherichia coli; Genetics, Microbial; RNA, Bacterial; RNA, Transfer; Serine; Suppression, Genetic; Tryptophan; Tyrosine | 1968 |
Amino acid transport systems in Escherichia coli K-12.
Topics: Alanine; Amino Acids; Azides; Biological Transport; Calcium; Carbon Isotopes; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Leucine; Methionine; Phenylalanine; Serine; Sodium; Temperature; Tryptophan; Tyrosine; Valine | 1968 |
Chromatographic alterations in transfer RNA's accompanying speciation, differentiation and tumor formation.
Topics: Adenoviridae; Animals; Biological Evolution; Brain; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cattle; Chickens; Chromatography; Cricetinae; Culture Techniques; Embryo, Mammalian; Embryo, Nonmammalian; Escherichia coli; Fibroblasts; Glycine; HeLa Cells; Humans; Kidney; Leucine; Liver; Mice; Muscles; Organ Specificity; Phenylalanine; Rabbits; RNA, Neoplasm; RNA, Transfer; Saccharomyces; Serine; Species Specificity; Tritium; Tyrosine | 1968 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
Suppressor selectrion for amino acid replacements expected on the basis of the genetic code.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Bacterial Proteins; Escherichia coli; Genes; Genetic Code; Genetics, Microbial; Glutamates; Glycine; Histidine; Hydro-Lyases; Isoleucine; Leucine; Lysine; Methionine; Mutation; Nucleotides; Phenylalanine; RNA, Messenger; Serine; Suppression, Genetic; Threonine; Tyrosine; Valine | 1967 |
The amino acid sequence of two O-phosphoserine containing tripeptides isolated from the organic matrix of embryonic bovine enamel.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Carboxypeptidases; Cattle; Chromatography, Ion Exchange; Chromatography, Thin Layer; Dental Enamel; Electrophoresis; Escherichia coli; Glutamates; Leucine; Leucyl Aminopeptidase; Naphthalenes; Peptides; Phosphorus; Serine; Sulfonic Acids; Thiocyanates; Tyrosine | 1969 |
Fidelity of genetic code translation in a rat liver ribosomal system.
Topics: Animals; Carbon Isotopes; Escherichia coli; Genetic Code; Isoleucine; Liver; Male; Neomycin; Phenylalanine; Rats; Ribosomes; Serine; Streptomycin; Tyrosine | 1969 |
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
Topics: Alanine; Amino Acids; Ammonia; Catechols; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Culture Media; Cysteine; Electrophoresis; Escherichia coli; Feedback; Kinetics; Lyases; Methods; Molecular Weight; Phenols; Protamines; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Stereoisomerism; Sulfates; Tyrosine; Ultracentrifugation | 1970 |
On the chemical structure of antigens and antibodies bound to fluorescent dyes. I. Structure of the antihuman gamma-globulin of the goat bound to the fluorochrome lissamine rhodamine B.
Topics: Amino Acids; Animals; Antibodies, Anti-Idiotypic; Antigens; Arginine; Aspartic Acid; Chromatography, Paper; Chymotrypsin; Electrophoresis; Fluorescent Dyes; Fluorometry; Goats; Histidine; Lysine; Oxidation-Reduction; Pepsin A; Protein Binding; Serine; Sulfides; Trypsin; Tryptophan; Tyrosine | 1966 |
Horse liver alcohol dehydrogenase. The primary structure of an N-terminal part of the protein chain of the ethanol-active isoenzyme.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Binding Sites; Carbon Isotopes; Chromatography, Gel; Chymotrypsin; Crustacea; Cyanides; Cysteine; Ethanol; Glyceraldehyde-3-Phosphate Dehydrogenases; Horses; Iodoacetates; Isoenzymes; Liver; Maleates; Pepsin A; Serine; Species Specificity; Swine; Trypsin; Tryptophan; Tyrosine | 1970 |
Chemical modifications of transfer RNA species. Desulfurization with Raney nickel.
Topics: Catalysis; Chemical Phenomena; Chemistry; Chromatography, Paper; Escherichia coli; Nickel; Nucleosides; Phenylalanine; Plant Growth Regulators; RNA, Bacterial; RNA, Transfer; Serine; Spectrum Analysis; Sulfur; Tyrosine | 1971 |
The primary structure of transfer ribonucleic acid.
Topics: Alanine; Aspartic Acid; Cryptococcus; Escherichia coli; Genetic Code; Isoleucine; Leucine; Methionine; Methylation; Nucleotides; Phenylalanine; RNA, Transfer; Saccharomyces; Serine; Tryptophan; Tyrosine; Valine | 1971 |
2'-O-Methyl polynucleotides as templates for cell-free amino acid incorporation.
Topics: Adenine Nucleotides; Amino Acids; Carbon Isotopes; Cell-Free System; Centrifugation, Density Gradient; Cytosine Nucleotides; Escherichia coli; Ethers; Genetic Code; Isoleucine; Kinetics; Leucine; Methanol; Methylation; Molecular Biology; Neomycin; Phenylalanine; Polynucleotides; Proline; Protein Biosynthesis; Ribonucleotides; RNA, Bacterial; Serine; Templates, Genetic; Tyrosine; Uracil Nucleotides | 1971 |
Fractionation of the nonpolar transfer ribonucleic acids from rat liver, yeast, and Escherichia coli by partition chromatography.
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Chromatography; Chromatography, Gel; Cysteine; Escherichia coli; Genetic Code; Glutamates; Leucine; Liver; Lysine; Methionine; Nucleosides; Phenylalanine; Rats; RNA, Transfer; Saccharomyces; Serine; Species Specificity; Spectrophotometry; Tryptophan; Tyrosine; Ultraviolet Rays | 1971 |
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.
Topics: Acetates; Amino Acid Sequence; Amino Acids; Anhydrides; Animals; Arginine; Chemical Phenomena; Chemistry; Chymotrypsin; Endopeptidases; Follicle Stimulating Hormone; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Hypothalamus; Leucine; Luteinizing Hormone; Mass Spectrometry; Methods; Naphthalenes; Peptides; Pituitary Hormone-Releasing Hormones; Proline; Serine; Sulfonic Acids; Swine; Thiocyanates; Tritium; Tryptophan; Tyrosine | 1971 |
Structure-function relationships of the acyl-carrier protein of Escherichia coli.
Topics: Alkylation; Aminopeptidases; Aspartic Acid; Bacterial Proteins; Carbon Dioxide; Carrier Proteins; Chemical Phenomena; Chemistry; Coenzyme A; Escherichia coli; Iodoacetates; Malonates; Methionine; Nitro Compounds; Optical Rotatory Dispersion; Palmitic Acids; Peptides; Protein Binding; Protein Conformation; Protein Denaturation; Serine; Structure-Activity Relationship; Temperature; Tyrosine; Urea | 1971 |
Amino-acid protection of ultra-violet-irradiated Bacillus subtilis.
Topics: Acid-Base Equilibrium; Alanine; Bacillus subtilis; Culture Media; Glycine; Histidine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Ultraviolet Rays | 1966 |
"Fetal PKU:" the effect of maternal hyperphenylalaninemia during pregnancy in the rhesus monkey (Macaca mulatta).
Topics: Amino Acids; Animals; Animals, Newborn; Birth Weight; Diet; Female; Fetal Diseases; Haplorhini; Humans; Intellectual Disability; Learning; Maternal-Fetal Exchange; Phenylalanine; Phenylketonurias; Pregnancy; Pregnancy Complications; Serine; Tyrosine | 1968 |
The free amino acids of serum during development of M. mulatta. I. During the first year of life.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Animals, Laboratory; Female; Haplorhini; Histidine; Leucine; Lysine; Milk; Pregnancy; Serine; Taurine; Tyrosine | 1968 |
On the C-terminal amino acid of bacterial alpha-amylase.
Topics: Alanine; Amino Acid Sequence; Amylases; Aspartic Acid; Bacillus subtilis; Carbon; Chemical Phenomena; Chemistry; Electrophoresis; Glutamates; Glycine; Isoleucine; Leucine; Lysine; Paper; Serine; Threonine; Tyrosine; Valine | 1968 |
Comparison of the specificities of various serine proteinases from microorganisms.
Topics: Amino Acids; Aspergillus; Bacillus subtilis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Hydrogen-Ion Concentration; Insulin; Kinetics; Leucine; Peptide Hydrolases; Peptides; Phenylalanine; Protease Inhibitors; Serine; Streptomyces; Tyrosine | 1969 |
The localization of N6-(delta 2-isopentenyl) adenosine among the acceptor species of transfer ribonucleic acid of Lactobacillu acidophilus.
Topics: Alkenes; Amino Acids; Anhydrides; Carbon Isotopes; Cellulose; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Ion Exchange; Culture Media; Cysteine; Genetic Code; Lactobacillus acidophilus; Leucine; Mevalonic Acid; Nucleosides; RNA, Bacterial; RNA, Transfer; Serine; Tritium; Tryptophan; Tyrosine | 1969 |
Structure and properties of hemocyanins. IV. Dissociation of Helix pomatia hemocyanin by succinylation into functional subunits.
Topics: Anhydrides; Animals; Carbohydrates; Chemical Phenomena; Chemistry; Chromatography, Gel; Copper; Dextrans; Edetic Acid; Hemocyanins; Microscopy, Electron; Molecular Weight; Osmolar Concentration; Oxygen; Protein Binding; Serine; Snails; Spectrum Analysis; Succinates; Threonine; Tyrosine; Ultracentrifugation; Viscosity | 1969 |
An effect of temperature on the Bacillus subtillis transfer RNA's which respond to codons beginning with U and A correlation with cytokinin activity.
Topics: Adenine; Bacillus subtilis; Binding Sites; Chromatography, DEAE-Cellulose; Cystine; Ethanol; Genetic Code; Hot Temperature; Kinins; Leucine; Phenylalanine; RNA, Bacterial; RNA, Transfer; Serine; Sodium Chloride; Tryptophan; Tyrosine; Uridine | 1970 |
Transfer RNA patterns in livers of rats fed diets containing 3'-methyl-4-dimethylaminoazobenzene.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Chromatography; Female; Histidine; Leucine; Liver Diseases; Lysine; Methionine; Methylation; p-Dimethylaminoazobenzene; Phenylalanine; Precancerous Conditions; Rats; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine; Valine | 1970 |
Plasma amino acid levels in diabetic ketoacidosis.
Topics: Adolescent; Adult; Aged; Alanine; Amino Acids; Arginine; Butyrates; Child; Citrulline; Cystine; Diabetic Ketoacidosis; Female; Glycine; Histidine; Humans; Insulin; Isoleucine; Leucine; Lysine; Male; Methionine; Middle Aged; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1970 |
[Glycopeptides of immunoglobulins, Microheterogeneity of the oligosaccharide chains of an immunoglobulin M from Waldenstrom's disease].
Topics: Amino Acid Sequence; Aspartic Acid; Autoanalysis; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Fucose; Galactose; Glucosamine; Glutamates; Histidine; Humans; Immunoglobulin M; Immunoglobulins; Lysine; Mannose; Neuraminic Acids; Oligosaccharides; Papain; Peptides; Proline; Serine; Threonine; Tyrosine; Valine; Waldenstrom Macroglobulinemia | 1970 |
Enzymatic preparation of L-tyrosine and 3,4-dihydroxyphenyl-L-alanine.
Topics: Ammonium Chloride; Autoanalysis; Catechols; Culture Media; Dihydroxyphenylalanine; Edetic Acid; Erwinia; Infrared Rays; Isomerism; Light; Lyases; Magnetic Resonance Spectroscopy; Methods; Phenols; Rotation; Serine; Spectrophotometry; Sulfites; Temperature; Time Factors; Tyrosine | 1971 |
[Kinetics of serine proteases from microorganisms].
Topics: Arginine; Aspergillus; Bacillus subtilis; Caseins; Chloromercuribenzoates; Endopeptidases; Hemoglobins; Hydrogen-Ion Concentration; Kinetics; Phenylbutyrates; Protease Inhibitors; Serine; Temperature; Tyrosine | 1971 |
The effect of a single oral dose of lysine or arginine on the excretion of free amino acids by the starved laying hen.
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Arginine; Chickens; Female; Glycine; Histidine; Isoleucine; Lysine; Ornithine; Serine; Starvation; Time Factors; Tyrosine | 1972 |
Effect of apomorphine on motility in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Benzoates; Benzyl Compounds; Brain Chemistry; Catecholamines; Cocaine; Desipramine; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Esters; Fluorine; Haloperidol; Hydrazines; Male; Motor Activity; Nialamide; Nortriptyline; Phenoxybenzamine; Rats; Rats, Inbred Strains; Reserpine; Serine; Spiro Compounds; Stimulation, Chemical; Thiocarbamates; Tranquilizing Agents; Tyrosine | 1972 |
Urinary aminograms in normal infants and children.
Topics: Adolescent; Alanine; Child; Child, Preschool; Glutamates; Glycine; Histidine; Humans; Infant; Infant, Newborn; Renal Aminoacidurias; Serine; Taurine; Tyrosine | 1972 |
Characteristics of amino acid accumulation by synaptosomal particles isolated from rat brain.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Brain; Carbon Isotopes; Leucine; Lysine; Nerve Endings; Ouabain; Potassium; Proline; Rats; Serine; Sodium; Stimulation, Chemical; Synaptic Vesicles; Synaptosomes; Threonine; Tyrosine; Valine | 1972 |
Crystal structure of a subtilisin BPN' complex with N-benzoyl-L-arginine.
Topics: Amides; Arginine; Asparagine; Bacillus; Benzoates; Binding Sites; Carboxylic Acids; Crystallography; Esters; Guanidines; Ketones; Models, Structural; Peptide Biosynthesis; Peptide Chain Elongation, Translational; Peptide Hydrolases; Protease Inhibitors; Protein Conformation; Serine; Tyrosine; X-Ray Diffraction | 1972 |
Net metabolism of plasma amino acids by liver and portal-drained viscera of fed sheep.
Topics: Alanine; Amino Acids; Ammonia; Animal Feed; Animals; Arginine; Aspartic Acid; Blood Flow Velocity; Dietary Proteins; Digestive System; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Liver; Liver Circulation; Nitrogen; Ornithine; Phenylalanine; Serine; Sheep; Tyrosine; Valine | 1972 |
Action of organophosphates and sulfonyl halides on porcine pancreatic lipase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Bile Acids and Salts; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Dansyl Compounds; Histidine; Iodoacetates; Isoflurophate; Lipase; Nitrophenols; Pancreas; Peptides; Phosphoric Acids; Phosphorus Isotopes; Serine; Structure-Activity Relationship; Sulfonic Acids; Sulfur Isotopes; Tyrosine | 1972 |
Amino acids in amniotic fluid: changes in concentrations during the first half of pregnancy.
Topics: Abortion, Therapeutic; Adult; Alanine; Amino Acids; Amniotic Fluid; Arginine; Chromatography, Ion Exchange; Female; Gestational Age; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Serine; Tyrosine; Valine | 1972 |
Amino acid patterns in the blood plasma of the young bovine.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cattle; Cystine; Female; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1972 |
Plasma amino acid response in young men given diets devoid of single essential amino acids.
Topics: Adolescent; Adult; Amino Acids; Deficiency Diseases; Dietary Proteins; Fasting; Female; Humans; Isoleucine; Leucine; Lysine; Male; Nutritional Physiological Phenomena; Nutritional Requirements; Phenylalanine; Serine; Threonine; Time Factors; Tyrosine; Valine | 1972 |
Specific O-acylation of hydroxylamino acids in presence of free amino groups.
Topics: Acetates; Acylation; Amino Acids; Animals; Carboxylic Acids; Cattle; Chemical Phenomena; Chemistry; Chlorine; Drug Stability; Fluoroacetates; Insulin; Pancreas; Peptides; Ribonucleases; Serine; Spectrophotometry; Threonine; Tyrosine; Ultraviolet Rays | 1972 |
Aminoacyl transfer RNA profiles in human myeloma cells.
Topics: Acyltransferases; Aspartic Acid; Carbon Isotopes; Cell Line; Chromatography; Culture Techniques; Humans; Leucine; Lymphocytes; Multiple Myeloma; RNA, Transfer; Serine; Tritium; Tyrosine | 1971 |
Effect of excess levels of individual amino acids on growth of rats fed casein diets.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Caseins; Cystine; Depression, Chemical; Dietary Proteins; DNA; Glutamates; Glycine; Growth; Histidine; Isoleucine; Leucine; Liver; Lysine; Male; Methionine; Organ Size; Phenylalanine; Proline; Proteins; Rats; RNA; Serine; Stereoisomerism; Stimulation, Chemical; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
Effect of dietary protein level on plasma free amino acids in the chicken.
Topics: Alanine; Amino Acids; Animals; Blood; Body Weight; Caseins; Chickens; Depression, Chemical; Dietary Proteins; Glycine; Isoleucine; Leucine; Lysine; Male; Methionine; Proline; Proteins; Serine; Stimulation, Chemical; Threonine; Tyrosine; Valine | 1971 |
Quantitative changes in plasma amino acids induced by oral contraceptives.
Topics: Adult; Alanine; Amino Acids; Contraceptives, Oral; Female; Glutamine; Glycine; Gonadal Steroid Hormones; Humans; Isoleucine; Leucine; Ornithine; Ovulation; Proline; Serine; Tyrosine; Valine | 1971 |
Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy. Preliminary report.
Topics: Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Arginine; Aspartic Acid; Citrulline; Cystine; Female; Gestational Age; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Proline; Serine; Threonine; Tyrosine; Valine | 1971 |
Quantitative protein sequencing using mass spectrometry: mass spectral analysis of 2-anilino-5-thiazolinone derivatives of amino acids without prior conversion to the phenyl thiohydantoins.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Aniline Compounds; Animals; Arginine; Autoanalysis; Cattle; Chemical Phenomena; Chemistry; Drug Stability; Glutamates; Hydantoins; Lysine; Mass Spectrometry; Methods; Phenylalanine; Ribonucleases; Serine; Sulfides; Thiazoles; Thiocyanates; Threonine; Tyrosine | 1971 |
Daily variations in the concentrations of individual amino acids in rat plasma.
Topics: Alanine; Amino Acids; Animals; Circadian Rhythm; Glutamates; Glycine; Isoleucine; Leucine; Methionine; Phenylalanine; Rats; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
Comparison of amino acid concentrations between plasma and erythrocytes. Studies in normal human subjects and those with metabolic disorders.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Arginine; Aspartic Acid; Biological Transport; Child; Chromatography, Ion Exchange; Cystine; Erythrocytes; Glutamates; Glutathione; Glycine; Histidine; Homocystine; Homocystinuria; Humans; Infant; Maple Syrup Urine Disease; Methionine; Ornithine; Phenylketonurias; Plasma; Renal Tubular Transport, Inborn Errors; Serine; Spectrophotometry; Threonine; Tyrosine | 1971 |
The effect of dietary fluoride on plasma free amino acid concentrations in the rat.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Diet; Feeding Behavior; Female; Fluorides; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rats; Rats, Inbred Strains; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
The effect of vitamin C depletion on the free amino acid content in blood plasma of the guinea pig.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Ascorbic Acid Deficiency; Aspartic Acid; Citrulline; Cysteine; Glutamates; Glycine; Guinea Pigs; Histidine; Isoleucine; Lysine; Male; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Time Factors; Tyrosine; Valine | 1971 |
Thermal titrimetric evaluation of the heats of ionization of the commonly occurring amino acids and their derivatives.
Topics: Acetates; Amino Acids; Ammonium Chloride; Calorimetry; Chemical Phenomena; Chemistry, Physical; Dithiothreitol; Histidine; Imidazoles; Ions; Lysine; Mathematics; Methods; Phenols; Serine; Thermodynamics; Tyrosine | 1971 |
The effect of diethyl pyrocarbonate on the transfer RNA of bovine muscle.
Topics: Alanine; Amino Acyl-tRNA Synthetases; Animals; Aspartic Acid; Carbon Isotopes; Carbonates; Cattle; Chemical Phenomena; Chemistry; Chromatography; Chromatography, DEAE-Cellulose; Diaphragm; Histidine; Lens, Crystalline; Leucine; Liver; Lysine; Methionine; Muscles; Phenylalanine; Rats; RNA, Transfer; Serine; Tyrosine; Valine | 1971 |
Comparative study of various serine proteinases from microorganisms: specificity with oligopeptides.
Topics: Alanine; Aspergillus; Bacillus; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Disc; Endopeptidases; Glycine; Hydrogen-Ion Concentration; Hydrolysis; Leucine; Peptides; Phenylalanine; Protease Inhibitors; Serine; Species Specificity; Streptomyces; Tyrosine | 1971 |
Sequence and structure of a cysteinyl flavin peptide from monoamine oxidase.
Topics: Amino Acid Sequence; Aminopeptidases; Binding Sites; Chromatography, Paper; Cysteine; Electrophoresis, Paper; Flavin-Adenine Dinucleotide; Fluorometry; Formates; Glycine; Hydrolysis; Indicators and Reagents; Liver; Monoamine Oxidase; Oxidation-Reduction; Peptides; Protein Binding; Serine; Spectrophotometry; Tyrosine | 1971 |
The extraction of a protein fraction rich in glycine, serine, tyrosine, and phenylalanine from Merino wool.
Topics: Animals; Chromatography; Dialysis; Electrophoresis, Disc; Ethanol; Glycine; Molecular Weight; Phenylalanine; Proteins; Serine; Sheep; Tyrosine; Wool | 1971 |
Stability of chromatographic patterns of aminoacyl transfer ribonucleic acid from individual mouse plasmacytomas and variability among different immunoglobulin A producing plasmacytomas and normal organs.
Topics: Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chromatography; Drug Stability; Immunoglobulin A; Kidney; Leucine; Liver; Male; Mice; Mice, Inbred Strains; Multiple Myeloma; Plasmacytoma; RNA, Transfer; Serine; Spleen; Testis; Time Factors; Tritium; Tyrosine | 1971 |
The characterization of hereditary abnormalities of keratin: Clouston's ectodermal dysplasia.
Topics: Ectodermal Dysplasia; Genes, Dominant; Hair; Humans; Keratosis; Nails, Malformed; Phenylalanine; Proline; Serine; Sulfur; Tyrosine; Urea; Water | 1971 |
The influence of short-range interactions on protein conformation. I. Side chain-backbone interactions within a single peptide unit.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Binding Sites; Cystine; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Kinetics; Leucine; Lysine; Methionine; Muramidase; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1968 |
Pyridoxine deficiency and brain amino acids.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Diet; Glutamates; Glycine; Lactates; Methionine; Mice; Quaternary Ammonium Compounds; Seizures; Serine; Thiosemicarbazones; Tyrosine; Urea; Vitamin B 6 Deficiency | 1969 |
Isoaccepting transfer RNA's of L-M cells in culture and after tumor induction in C3H mice.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Cell Line; Chromatography; Connective Tissue; Culture Media; Culture Techniques; Female; Fibrosarcoma; Glycine; Histidine; Isoleucine; Leucine; Ligases; Lysine; Male; Methionine; Mice; Phenylalanine; Proline; RNA, Transfer; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
Transfer RNA species in normal and leukemic human lymphoblasts.
Topics: Amino Acids; Carbon Isotopes; Cell Line; Chromatography; Glutamine; Glycine; Humans; Leucine; Leukemia, Lymphoid; Ligases; Lymphocytes; Proline; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine | 1970 |
[Distribution of free amino acids in plasma in patients with a chronic lymphatic and acute leukemia].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Citrulline; Cystine; Glutamates; Glutamine; Glycine; Histidine; Humans; Isoleucine; Leucine; Leukemia, Lymphoid; Lysine; Methionine; Ornithine; Phenylalanine; Prednisolone; Proline; Serine; Threonine; Triethylenemelamine; Tyrosine; Valine; Vincristine | 1971 |
Non-pancreatic proteases of the chymotrypsin family. I. A chymotrypsin-like protease from rat mast cells.
Topics: Acrylates; Animals; Arginine; Benzoates; Binding Sites; Cell Count; Cell Fractionation; Cell Nucleus; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Dextrans; Endopeptidases; Enzyme Precursors; Esters; Gels; Histidine; Hydrogen-Ion Concentration; Isoflurophate; Ketones; Kinetics; Male; Mast Cells; Methods; Microscopy, Electron; Molecular Weight; Osmolar Concentration; Peritoneal Cavity; Phosphorus Isotopes; Potassium Chloride; Rats; Serine; Sulfonic Acids; Toluene; Tritium; Tyrosine | 1971 |
Amber suppression and activating enzymes.
Topics: Escherichia coli; Genes; Glutamine; Ligases; Methionine; Molecular Biology; RNA, Bacterial; RNA, Transfer; Serine; Tyrosine | 1966 |
Imidazolylacetolphosphate:L-glutamate aminotransferase. Composition and substructure.
Topics: Alanine; Ammonia; Arginine; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Electrophoresis; Genes; Glycine; Histidine; Leucine; Methionine; Molecular Biology; Molecular Weight; Peptides; Phenylalanine; Proline; Salmonella typhimurium; Serine; Threonine; Transaminases; Tyrosine; Valine | 1967 |
Structural comparison of the hemoglobins of the genus Equus with those of ruminants.
Topics: Alleles; Amino Acid Sequence; Amino Acids; Animals; Biological Evolution; Blood Protein Electrophoresis; Chemical Phenomena; Chemistry; Female; Glycine; Hemoglobins; Horses; Male; Methods; Models, Biological; Molecular Biology; Peptides; Perissodactyla; Phenylalanine; Polymorphism, Genetic; Serine; Sheep; Species Specificity; Tyrosine | 1969 |
Changes in free amino acids of tomato fruit under pathogenesis.
Topics: Alanine; Amino Acids; Aminobutyrates; Arginine; Aspartic Acid; Fruit; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Plant Diseases; Serine; Threonine; Tyrosine; Valine | 1969 |
Biosynthesis of chloramphenicol.
Topics: Aldehyde-Lyases; Carbon Isotopes; Chemical Phenomena; Chemistry; Chloramphenicol; Nitrogen; Phenylalanine; Radioisotopes; Serine; Shikimic Acid; Streptomyces; Tyrosine | 1969 |
The nature of amino-acid chloranil complexes.
Topics: Amino Acids; Chemical Phenomena; Chemistry, Physical; Glutamates; Glycine; Hydrogen-Ion Concentration; Infrared Rays; Quinones; Serine; Spectrophotometry; Tryptophan; Tyrosine; Valine | 1969 |
Transaminase activity in sheep rumen content.
Topics: Alanine; Alanine Transaminase; Animals; Arginine; Aspartic Acid; Cysteine; Eukaryota; Glutamates; Hydrogen-Ion Concentration; Isoleucine; Leucine; Methionine; Phenylalanine; Rumen; Serine; Sheep; Temperature; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
[Chemical and physico-chemical properties of placental protein with antineoplastic effect].
Topics: Alanine; Amino Acids; Ammonia; Antineoplastic Agents; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Electrophoresis; Female; Glutamates; Glycine; Histidine; Humans; Leucine; Lysine; Phenylalanine; Placenta; Proline; Proteins; Serine; Threonine; Tyrosine; Valine | 1969 |
Study on the amino acid composition in the cornea of hypophysectomized rat.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cornea; Cystine; Electrophoresis; Glutamates; Glycine; Growth Hormone; Histidine; Hypophysectomy; Leucine; Lysine; Methionine; Phenylalanine; Pituitary Gland; Rats; Serine; Threonine; Tyrosine | 1969 |
Studies on protein-like products from radiofrequency plasmas of Co, N2 and H2.
Topics: Alanine; Carbon Monoxide; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Glutamates; Glycine; Hydrogen; Nitrogen; Proteins; Pyridines; Serine; Tyrosine; Ultraviolet Rays | 1970 |
Peptidyl transfer RNA. X. The chemical synthesis of peptidyl transfer RNA containing hydroxy amino acids.
Topics: Carbon Isotopes; Hydrogen-Ion Concentration; Imides; Methods; Peptides; Phenylalanine; RNA, Transfer; Serine; Thiosulfates; Tyrosine | 1970 |
Comparative sensitivity of specific amino acid ratios versus "essential to nonessential" amino acid ratio.
Topics: Adult; Amino Acids; Child; Cystine; Diet; Female; Glycine; Humans; Isoleucine; Kwashiorkor; Leucine; Nutrition Disorders; Pregnancy; Serine; Socioeconomic Factors; Tyrosine; Valine | 1970 |
Molecular weight and amino acid composition of five-times-crystallized phosphoglucose isomerase from rabbit skeletal muscle.
Topics: Amides; Amino Acids; Animals; Barium; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Crystallization; Cysteine; Diffusion; Glucose-6-Phosphate Isomerase; Hydrochloric Acid; Hydroxides; Molecular Weight; Muscles; Nitrogen; Oxygen; Rabbits; Serine; Threonine; Tryptophan; Tyrosine; Ultracentrifugation; Viscosity | 1970 |
Circadian ythm of human urinary amino acid excretion in fed and fasted states.
Topics: 17-Hydroxycorticosteroids; Adult; Alanine; Amino Acids; Asparagine; Circadian Rhythm; Cystinuria; Fasting; Feeding Behavior; Glutamates; Glutamine; Glycine; Humans; Male; Middle Aged; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1970 |
Changes in the concentration of specific amino acids in the serum of experimentally malnourished pigs.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Dietary Proteins; Female; Gluconeogenesis; Glycine; Histidine; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proline; Protein Deficiency; Serine; Swine; Threonine; Tyrosine; Valine | 1970 |
Methionine toxicity and ornithine delta-aminotransferase in Chang's liver cells.
Topics: Arginine; Carbon Isotopes; Cell Division; Cell Line; Glycine; Histidine; Homocysteine; Humans; Kidney; Leucine; Liver; Methionine; Ornithine; Proteins; Serine; Stimulation, Chemical; Transaminases; Tryptophan; Tyrosine | 1970 |
The transient inactivation of trypsin by mild acetylation with N-acetylimidazole.
Topics: Acetates; Animals; Binding Sites; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Histidine; Hydrogen-Ion Concentration; Imidazoles; Isoflurophate; Lysine; Models, Chemical; Phosphorus Isotopes; Serine; Solvents; Spectrophotometry; Trypsin; Tyrosine | 1970 |
Nitrogenous compounds immobilized in an aged rat.
Topics: Age Factors; Amino Acids; Animals; Arginine; Aspartic Acid; Chromatography, Gas; Chromatography, Paper; Electrophoresis; Female; Glutamates; Liver; Lysine; Magnetic Resonance Spectroscopy; Pregnancy; Rats; Serine; Tritium; Tyrosine | 1970 |
In vitro methylation of yeast serine transfer ribonucleic acid.
Topics: Adenine; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Kinetics; Methylation; Phenylalanine; Rats; Ribonucleases; RNA, Transfer; Saccharomyces; Serine; Transferases; Tritium; Tyrosine; Valine | 1970 |
Determination of pico-mole quantities of gamma-amino-butyric acid (GABA) and serotonin.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoradiography; Brain Chemistry; Carbon Isotopes; Cerebellum; Chromatography; Cysteine; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methods; Microchemistry; Phenylalanine; Proline; Radionuclide Imaging; Rats; Serine; Serotonin; Threonine; Tyrosine; Valine | 1970 |
The effect of inhibition of catecholamine synthesis on dexamphetamine induced central stimulation.
Topics: Amino Acids; Animals; Brain Chemistry; Catecholamines; Central Nervous System; Dextroamphetamine; Dopamine Antagonists; Esters; Female; Mice; Mixed Function Oxygenases; Motor Activity; Norepinephrine; Piperazines; Reserpine; Serine; Stimulation, Chemical; Sulfides; Thiocarbamates; Tyrosine | 1970 |
X-ray diffraction studies of enzymes.
Topics: Albumins; Binding Sites; Carboxypeptidases; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Enzymes; Glycine; Methods; Models, Structural; Muramidase; Pancreas; Papain; Peptide Hydrolases; Protein Binding; Ribonucleases; Serine; Thermodynamics; Tyrosine; X-Ray Diffraction | 1970 |
Glutamine in the phenylketonuric central nervous system.
Topics: Adolescent; Adult; Amino Acids; Biological Transport, Active; Brain; Brain Chemistry; Child; Female; Glutamine; Histidine; Humans; Intellectual Disability; Intelligence Tests; Male; Middle Aged; Phenylketonurias; Serine; Threonine; Tyrosine | 1970 |
A new hypothesis on the evolution of the genetic code.
Topics: Amino Acids; Arginine; Asparagine; Biological Evolution; Cysteine; Genetic Code; Glutamine; Leucine; Lysine; Methionine; Models, Chemical; Models, Structural; Nucleotides; Proline; Serine; Threonine; Tyrosine | 1970 |
Reaction of tobacco mosaic virus with maleic anhydride and some possible applications to x-ray diffraction analysis.
Topics: Amino Acids; Anhydrides; Autoradiography; Binding Sites; Carbon Isotopes; Centrifugation; Chemical Phenomena; Chemistry; Densitometry; Electrophoresis; Hydrogen-Ion Concentration; Hydrolysis; Hydroxylamines; Lysine; Maleates; Peptides; Serine; Spectrophotometry; Threonine; Tobacco Mosaic Virus; Trypsin; Tyrosine; Ultracentrifugation; Ultraviolet Rays; Viral Proteins; X-Ray Diffraction | 1971 |
Nutrient media for plant-parasitic nematodes. II. Amino acid requirements of Aphelenchoides sp.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Thin Layer; Culture Media; Fungi; Germ-Free Life; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Nematoda; Nutritional Requirements; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1971 |
Amino acid metabolism in the isolated perfused rat liver.
Topics: Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Chromatography; Glutamates; Glycine; In Vitro Techniques; Liver; Lysine; Male; Methionine; Nitrogen Isotopes; Perfusion; Phenylalanine; Proline; Rats; Serine; Threonine; Tryptophan; Tyrosine; Urea | 1971 |
The entry of amino acids into the myocardium of the growing rat in vivo.
Topics: Amino Acids; Animals; Aspartic Acid; Diffusion; Glycine; Heart; Histidine; Isoleucine; Leucine; Lysine; Methionine; Myocardium; Phenylalanine; Protein Binding; Protein Biosynthesis; Rats; Serine; Taurine; Tryptophan; Tyrosine; Valine | 1971 |
Isolation and characterization of the cyanogen bromide peptides from the 1 and 2 chains of acid-soluble bovine skin collagen.
Topics: Amino Acid Sequence; Amino Acids; Animals; Autoanalysis; Cattle; Chickens; Chromatography, Ion Exchange; Collagen; Cyanides; Dipeptides; Electrophoresis, Disc; Glutamates; Humans; Hydrogen-Ion Concentration; Leucine; Male; Methods; Peptides; Protein Denaturation; Rats; Serine; Skin; Solubility; Species Specificity; Spectrophotometry; Terminology as Topic; Tyrosine; Ultraviolet Rays | 1971 |
Essential amino acids in the culture of Leishmania tarentolae.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Culture Media; Glucose; Glutamates; Glycine; Histidine; Leishmania; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1971 |
Molecular transport. I. In vivo studies of transport mutants of Neurospora crassa with altered amino acid competition patterns.
Topics: Alanine; Arginine; Aspartic Acid; Biological Transport, Active; Carbon Isotopes; Chromatography, Paper; Crosses, Genetic; Genetics, Microbial; Histidine; Isoleucine; Kinetics; Leucine; Lysine; Methionine; Mutation; Neurospora; Phenylalanine; Serine; Stereoisomerism; Threonine; Tyrosine; Valine | 1971 |
The disulfide bridge sequences of a serine protease of wide specificity from Streptomyces griseus.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Butanones; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Cystine; Electrophoresis; Esterases; Histidine; Insulin; Isoflurophate; Methionine; Methylcellulose; Peptide Hydrolases; Peptides; Serine; Streptomyces; Sulfides; Sulfonic Acids; Toluene; Tyrosine | 1971 |
Isolation and characterization of seryl-tRNA synthetase from yeast.
Topics: Autolysis; Chemistry Techniques, Analytical; Chromatography; Chromatography, DEAE-Cellulose; Electrophoresis; Electrophoresis, Disc; Gels; Ligases; Molecular Weight; RNA, Transfer; Serine; Spectrum Analysis; Tryptophan; Tyrosine; Ultracentrifugation; Ultraviolet Rays; Yeasts | 1971 |
Mechanism of suppression in Drosophila: a change in tyrosine transfer RNA.
Topics: Amino Acids; Animals; Carbon Isotopes; Chromatography; Drosophila; Genes, Recessive; Genetic Code; Leucine; Mutation; Phenylalanine; RNA, Transfer; Serine; Sex Chromosomes; Suppression, Genetic; Tritium; Tyrosine | 1971 |
[Hyperaminoaciduria in children suffering from progressive muscular dystrophy].
Topics: Adolescent; Alanine; Amino Acid Metabolism, Inborn Errors; Arginine; Aspartic Acid; Child; Child, Preschool; Creatine; Creatinine; Female; Glutamates; Histidine; Humans; Leucine; Lysine; Male; Methionine; Muscular Dystrophies; Nitrogen; Phenylalanine; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
[Quantitative paper chromatography amino acid determination. Stanardization of the procedure and method of testing of new paper types].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chromatography, Paper; Cysteine; Glutamates; Glycine; Histidine; Indicators and Reagents; Leucine; Lysine; Methionine; Methods; Paper; Phenylalanine; Serine; Spectrum Analysis; Sulfones; Threonine; Tyrosine; Ultraviolet Rays; Valine | 1967 |
Ammonia production by rumen microbes in vitro.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Asparagine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rumen; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Dipeptidyl arylamidase II of the pituitary. Properties of lysylalanyl-beta-naphthylamide hydrolysis: inhibition by cations, distribution in tissues, and subcellular localization.
Topics: Acid Phosphatase; Alanine; Animals; Arginine; Cattle; Centrifugation, Density Gradient; Chromatography, Paper; Cytoplasm; Dipeptides; Endopeptidases; Glycine; Hydrogen-Ion Concentration; Kidney; Kinetics; Leucine; Lithium; Lysine; Lysosomes; Methionine; Naphthalenes; Nucleosides; Pituitary Gland; Potassium; Proline; Protease Inhibitors; Puromycin; Rats; Serine; Sodium; Spleen; Thyroid Gland; Tromethamine; Tyrosine | 1968 |
[On a new carboxypeptidase (EC 3.4.2.?) from spleen].
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Carboxypeptidases; Cattle; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Glutamates; Glycine; Kinetics; Leucine; Peptides; Serine; Spleen; Tyrosine; Valine | 1968 |
Inhibition of heat-induced denaturation of serum proteins by mixtures of nonsteroidal anti-inflammatory agents and amino acids.
Topics: Amino Acids; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cysteine; Depression, Chemical; Flufenamic Acid; Fluorine; Histamine; Histidine; Hot Temperature; Indomethacin; ortho-Aminobenzoates; Phenylalanine; Phenylbutazone; Protein Denaturation; Serine; Serum Albumin, Bovine; Solutions; Tryptophan; Tyrosine | 1968 |
A study of 2,4,6-trinitrobenzenesulfonic acid for automated amino acid chromatography.
Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Autoanalysis; Chromatography; Cystine; Glycine; Histidine; Hydrogen-Ion Concentration; Indicators and Reagents; Isoleucine; Leucine; Lysine; Methionine; Methods; Nitrobenzenes; Phenylalanine; Proline; Serine; Spectrophotometry; Sulfonic Acids; Temperature; Threonine; Tryptophan; Tyrosine; Urea; Valine | 1968 |
Primary structure of insoluble tendon collagen. 3. Analysis of products of tryptic digestion of native collagen.
Topics: Achilles Tendon; Alanine; Aldehydes; Amino Acids; Animals; Arginine; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Cysteine; Electrophoresis; Glutamine; Glycine; Hexosamines; Histidine; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Proline; Serine; Sulfur; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Trace metal requirements for malformin biosynthesis.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Aspartic Acid; Aspergillus; Chromium; Cobalt; Copper; Cysteine; Glutamine; Glycine; Histidine; Iron; Isoleucine; Leucine; Lysine; Manganese; Metals; Molybdenum; Peptide Biosynthesis; Phenylalanine; Plant Growth Regulators; Proline; Serine; Trace Elements; Tryptophan; Tyrosine; Valine; Zinc | 1968 |
Kinetics of the photochemical addition of [35S] cysteine to polynucleotides and nucleic acids.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cysteine; DNA; Kinetics; Methionine; Polynucleotides; RNA; Saccharomyces; Serine; Sulfur Isotopes; Threonine; Thymus Gland; Tyrosine; Ultraviolet Rays | 1968 |
The substrate specificity of guinea-pig plasma kallikrein.
Topics: Amides; Animals; Arginine; Chemical Phenomena; Chemistry; Esters; Guinea Pigs; Hydrogen-Ion Concentration; Kallikreins; Kinetics; Lysine; Serine; Threonine; Tyrosine | 1968 |
Structural analysis of the glycine-rich, arginine-rich histone. I. Sequence of the carbosyl-terminal portion.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Bromine; Carboxypeptidases; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Electrophoresis; Glycine; Histones; Peptides; Phenylalanine; Serine; Thymus Gland; Trypsin; Tyrosine | 1968 |
Calf and pea histone IV. I. Amino acid compositions and the identical COOH-terminal 19-residue sequence.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Biological Evolution; Bromine; Cattle; Chromatography, Gel; Chymotrypsin; Cyanides; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Plants; Proline; Serine; Threonine; Trypsin; Tyrosine; Valine | 1968 |
Two procedures for accelerated separation of amino acids by column chromatography.
Topics: Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Buffers; Chromatography, Ion Exchange; Cystine; Glutamates; Glycine; Isoleucine; Leucine; Methionine; Methods; Phenylalanine; Proline; Serine; Temperature; Threonine; Tryptophan; Tyrosine; Valine | 1968 |
Gas chromatographic behavior of trimethylsilylated phenylthiohydantoin amino acids.
Topics: Alanine; Amino Acids; Arginine; Chromatography, Gas; Glutamates; Glutamine; Hydantoins; Leucine; Methionine; Methods; Methylation; Phenylalanine; Proline; Serine; Silicon; Spectrum Analysis; Tyrosine | 1968 |
States of amino acid residues in proteins. XVI. Naphthoquinones with two sulfonic groups as a reagent for discrimation of amino groups in proteins.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chymotrypsin; Colorimetry; Freezing; Glycine; Histidine; Hydrogen-Ion Concentration; Imidazoles; Indicators and Reagents; Insulin; Lysine; Muramidase; Naphthoquinones; Proline; Proteins; Ribonucleases; Serine; Spectrophotometry; Sulfonic Acids; Tryptophan; Tyrosine | 1968 |
Autodigestion of the main proteolytically active component of the stem bromelain.
Topics: Alanine; Arginine; Bromelains; Chromatography; Glutamates; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Peptides; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1968 |
[Levels of free amino acids in the blood and heart muscle in the human at various periods of myocardial infarct (clinical anatomical parallels)].
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Chromatography; Erythrocytes; Glutamates; Glycine; Histidine; Histocytochemistry; Humans; Isoleucine; Leucine; Lysine; Methods; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Phenylalanine; Serine; Threonine; Time Factors; Tyrosine; Valine | 1968 |
[Isolation and identification of a ninhydrin-positive complex from the brain under the effect of gamma-amino butyric acid].
Topics: Amino Acids; Aminobutyrates; Animals; Brain Chemistry; Carotid Arteries; Dogs; Drug Stability; Glycine; Indicators and Reagents; Injections, Intra-Arterial; Serine; Stimulation, Chemical; Threonine; Time Factors; Tyrosine | 1968 |
Umbilical vein-artery and uterine arterio-venous plasma amino acid differences (in the human subject).
Topics: Amino Acids; Analysis of Variance; Cesarean Section; Delivery, Obstetric; Female; Fetus; Gestational Age; Histidine; Humans; Infant, Newborn; Infant, Premature; Leucine; Lysine; Maternal-Fetal Exchange; Nitrogen; Phenylalanine; Placenta; Pregnancy; Serine; Tyrosine; Umbilical Arteries; Umbilical Veins; Uterus | 1969 |
Effect of glucagon on concentration of several free amino acids in plasma.
Topics: Alanine; Amino Acids; Arginine; Citrulline; Cystine; Depression, Chemical; Fasting; Female; Glucagon; Glycine; Histidine; Humans; Leucine; Liver; Lysine; Male; Methionine; Nitrogen; Phenylalanine; Progesterone; Proline; Serine; Threonine; Tyrosine; Valine | 1969 |
Kinetic properties of the alpha-lytic protease of Sorangium sp., a bacterial homologue of the pancreatopeptidases.
Topics: Acetates; Amino Acid Sequence; Arginine; Bacteria; Catalysis; Chymotrypsin; Deuterium; Electrophoresis; Esters; Histidine; Hydrogen-Ion Concentration; Kinetics; Nitrophenols; Pancreatic Elastase; Peptide Hydrolases; Protease Inhibitors; Protein Binding; Serine; Spectrophotometry; Trypsin; Tryptophan; Tyrosine | 1969 |
Fractionation of rat liver transfer ribonucleic acid. Isolation of tyrosine, valine, serine, and phenylalanine transfer ribonucleic acids and their coding properties.
Topics: Amino Acids; Animals; Carbon Isotopes; Chromatography, Gel; Chromatography, Ion Exchange; Genetic Code; Ligases; Liver; Male; Phenylalanine; Rats; Ribosomes; RNA, Transfer; Serine; Templates, Genetic; Tyrosine; Valine | 1969 |
Circadian periodicity of blood amino acids in normal and adrenalectomized mice.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Circadian Rhythm; Cystine; Densitometry; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Mice; Serine; Threonine; Tryptophan; Tryptophan Oxygenase; Tyrosine; Valine | 1969 |
Urinary amino acid and peptide excretion patterns in patients with muscular dystrophy (Duchenne). A preliminary study with the autoanalyzer.
Topics: Adolescent; Alanine; Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Autoanalysis; Child; Child, Preschool; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Male; Muscular Dystrophies; Peptides; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1969 |
Local solvent structure as a factor in secondary isotope fractionation phenomena of labeled amino acids on ion-exchange columns.
Topics: Alcohols; Amino Acids; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Glutamates; Glycine; Phenylalanine; Proline; Serine; Solvents; Tritium; Tyrosine | 1969 |
Subunit structure and chemical properties of rabbit liver aldolase.
Topics: Amino Acids; Animals; Carboxypeptidases; Chromatography, Gel; Detergents; Electrophoresis, Disc; Fructose-Bisphosphate Aldolase; Glycine; Guanidines; Hydrazines; Liver; Methionine; Methods; Molecular Weight; Muscles; Organ Specificity; Rabbits; Serine; Sulfates; Tyrosine; Ultracentrifugation | 1969 |
[Studies on the amino acid composition of some African legumes].
Topics: Amino Acids; Arginine; Aspartic Acid; Canavanine; Chromatography; Cystine; Food Analysis; Glutamine; Glycine; Histidine; Hot Temperature; Isoleucine; Leucine; Lysine; Methionine; Methods; Phenylalanine; Plants, Edible; Proline; Proteins; Serine; Threonine; Tryptophan; Tyrosine; Valine; Vegetables | 1969 |
Histones in early embryogenesis.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Echinodermata; Electrophoresis; Embryo, Nonmammalian; Fishes; Gels; Genetic Code; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; RNA; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1969 |
Determination of dinitrophenylamino acids in structural proteins by chromatography on nylon powder columns. I. The water-soluble dinitrophenylamino acids.
Topics: Amino Acids; Animals; Chromatography; Collagen; Cysteine; Dinitrophenols; Hair; Hydrogen-Ion Concentration; Lysine; Methods; Nylons; Proteins; Serine; Textiles; Tyrosine; Wool | 1969 |
Biosynthesis of insulin chains A and B.
Topics: Animals; Carbon Isotopes; Cysteine; Glycine; In Vitro Techniques; Insulin; Methylthiouracil; Pancreas; Radiometry; Rats; Serine; Sulfur Isotopes; Tyrosine | 1965 |
Incorporation of amino acid carbon into proteins by sheep thyroid gland mitochondria.
Topics: Amino Acids; Animals; Carbon Isotopes; Glutamates; In Vitro Techniques; Leucine; Mitochondria; Nitrobenzenes; Phenylalanine; Protein Biosynthesis; RNA; Serine; Sheep; Thyroid Gland; Tyrosine; Valine | 1964 |
Amber suppressors: efficiency of chain propagation and suppressor specific amino acids.
Topics: Amino Acids; Autoradiography; Coliphages; Genes; Glutamine; In Vitro Techniques; Molecular Biology; Mutation; Peptide Biosynthesis; Phenylalanine; Serine; Tyrosine | 1965 |
Labelling of beta-lipoprotein with tritium.
Topics: Acetates; Cholesterol; Immunoelectrophoresis; In Vitro Techniques; Indicators and Reagents; Lipoproteins; Methionine; Phenylalanine; Serine; Tritium; Tryptophan; Tyrosine | 1965 |
Amino acid analysis of fresh leaf litter and the nitrogen nutrition of some aquatic hyphomycetes.
Topics: Amino Acids; Arginine; Aspartic Acid; Carbon; Chromatography, Paper; Electrophoresis; In Vitro Techniques; Isoleucine; Lysine; Mitosporic Fungi; Nitrogen; Serine; Tyrosine | 1965 |
Regulation of amino acid accumulation in isolated rat diagphragm: effect of puromycin and insulin.
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Cystine; Diaphragm; Histidine; In Vitro Techniques; Insulin; Isoleucine; Leucine; Male; Muscles; Phenylalanine; Proteins; Puromycin; Rats; Serine; Tryptophan; Tyrosine | 1965 |
Products from the photolysis of diazoacetyl chymotrypsin.
Topics: Azo Compounds; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Glycolates; Histidine; Light; Serine; Tyrosine | 1966 |
Amino acids in seven species of cestodes.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Cestoda; Cystine; Glutamates; Glycine; Histidine; In Vitro Techniques; Isoleucine; Leucine; Lysine; Nitrogen; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1966 |
Fractionation of amino acid-specific s-RNA from silkgland by methylated albumin column chromatography.
Topics: Alanine; Albumins; Animals; Bombyx; Chemical Phenomena; Chemistry; Chemistry Techniques, Analytical; Chromatography; Glycine; In Vitro Techniques; Leucine; Lysine; Methionine; Phenylalanine; RNA, Transfer; Serine; Tyrosine | 1966 |
Titrimetric microdetermination of sulfur in biological materials.
Topics: Chlorides; Feces; Hexosephosphates; Methionine; Microchemistry; Nitrates; Phosphates; Phosphines; Quaternary Ammonium Compounds; Serine; Sulfates; Sulfur; Tyrosine | 1966 |
Polyamide layer chromatography of DNP-amino acids.
Topics: Alanine; Amides; Arginine; Aspartic Acid; Chromatography; Dinitrophenols; Glutamates; Glycine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1966 |
Nuclear histones and early embryogenesis of the chick.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Differentiation; Cell Division; Cell Nucleus; Chick Embryo; Electrophoresis; Glutamates; Glycine; Histidine; Histones; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1966 |
Indications for a common evolutionary origin shown in the primary structure of three transfer RNAs.
Topics: Alanine; Biological Evolution; Chemical Phenomena; Chemistry; Genetic Code; RNA, Transfer; Serine; Tyrosine; Yeasts | 1966 |
Analysis of N-methylamino acids by automatic amino acid analyzer and gas-liquid chromatography.
Topics: Alanine; Anti-Bacterial Agents; Arginine; Aspartic Acid; Autoanalysis; Chromatography, Gas; Cysteine; Cystine; Glutamates; Glycine; Indicators and Reagents; Isoleucine; Lysine; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1966 |
[Composition of the amino acid pool of Neurospora in deficiency of growth substance].
Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Biotin; Choline; Chromatography, Ion Exchange; Culture Media; Glutamates; Glycine; Growth Inhibitors; Lysine; Methionine; Mutation; Neurospora; Phenylalanine; Pyridoxine; Riboflavin; Serine; Threonine; Tyrosine; Valine | 1966 |
[The N-alpha-acetyl-methylamide of lysine, histidine, serine, tyrosine, cystine and tryptophan].
Topics: Chemical Phenomena; Chemistry; Cystine; Histidine; Lysine; Peptides; Serine; Tryptophan; Tyrosine | 1966 |
[On the structure of protamine. VII. On the effect of the age of the fishes on the composition of their protamine].
Topics: Age Factors; Alanine; Amino Acids; Animals; Arginine; Fishes; Glutamates; Proline; Protamines; Serine; Threonine; Tyrosine; Valine | 1966 |
[Chromatographic investigation of free amino acids of the heart, kidneys and brain in experimental myocarditis].
Topics: Alanine; Amino Acids; Animals; Arginine; Asparagine; Brain; Chromatography, Paper; Cystine; Glutamine; Glycine; Histidine; Kidney; Lysine; Methionine; Myocarditis; Myocardium; Phenylalanine; Rabbits; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1966 |
Free amino acids of human foetal and adult liver.
Topics: Adult; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Cystine; Female; Fetus; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Liver; Lysine; Methionine; Ornithine; Phenylalanine; Pregnancy; Proline; Serine; Taurine; Threonine; Tyrosine; Urea; Valine | 1966 |
Tryptophan deficiency in rabbit reticulocytes: polyribosomes during interrupted growth of hemoglobin chains.
Topics: Animals; Deficiency Diseases; Hemoglobins; Histidine; Leucine; Lysine; Phenylalanine; Rabbits; Reticulocytes; Ribosomes; Serine; Tryptophan; Tyrosine; Valine | 1967 |
Free amino acids in gamma-irradiated carrots.
Topics: Acetates; Alanine; Amino Acids; Aspartic Acid; Autoanalysis; Carbon Isotopes; Glutamates; Leucine; Methionine; Plants, Edible; Proline; Radiation Effects; Serine; Threonine; Tyrosine | 1967 |
Oligonucleoides from yeast tyrosine transfer ribonucleic acid.
Topics: Alanine; Chromatography; Nucleotides; Ribonucleases; RNA, Transfer; Serine; Spectrophotometry; Tyrosine; Yeasts | 1967 |
Further studies of amino acid transport by embryonic chick bone.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Bone and Bones; Chick Embryo; Dactinomycin; Ethylmaleimide; Glycine; In Vitro Techniques; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
A new developing solvent for paper chromatography of various phenolic compounds, sugars and amino acids.
Topics: Amino Acids; Anthocyanins; Arginine; Asparagine; Carbohydrates; Chromatography, Paper; Gallic Acid; Glutamates; Histidine; Indicators and Reagents; Leucine; Lysine; Methionine; Phenols; Phenylalanine; Phloroglucinol; Proline; Resorcinols; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Correlation between serine and thermal stability of collagen.
Topics: Animals; Annelida; Ascaris; Cattle; Collagen; Fishes; Hot Temperature; Humans; Hydroxyproline; Proline; Rats; Serine; Snails; Threonine; Tyrosine | 1967 |
Reactions in frozen systems. VI. Ice as a possible model for biological structured-water systems.
Topics: Acetylcholine; Asparagine; Catalysis; Chemical Phenomena; Chemistry; Copper; Cytosine; Dioxins; Glutamates; Glutamine; Glycine; Hydroxylamines; Ice; Imidazoles; Kinetics; Models, Theoretical; Nitrates; Phenylalanine; Piperazines; Potassium Chloride; Pyrazoles; Serine; Tyrosine | 1967 |
Synthesis and properties of some N-pyridoxyl-L-amino acids and N-(5-phosphopyridoxyl)-L-amino acids.
Topics: Alanine; Aldehydes; Arginine; Aspartic Acid; Chemistry, Organic; Chromatography, Paper; Glutamates; Organic Chemistry Phenomena; Pyridines; Pyridoxal Phosphate; Pyrrolidinones; Serine; Tryptophan; Tyrosine | 1967 |
Comparative studies of luteinizing hormone from beef, pork, and sheep pituitaries. II. The C-terminal amino acids.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Carboxypeptidases; Cattle; Eukaryota; Hot Temperature; Hydrazines; Hydrogen-Ion Concentration; In Vitro Techniques; Luteinizing Hormone; Peptides; Serine; Sheep; Swine; Tyrosine | 1967 |
The recovery of amino acids from acid hydrolysates of whole urine from patients with thermal burns.
Topics: Alanine; Amino Acids; Ammonia; Arginine; Aspartic Acid; Burns; Creatine; Glutamates; Glycine; Histidine; Humans; Hydroxyproline; Isoleucine; Leucine; Lysine; Ornithine; Phenylalanine; Proline; Serine; Taurine; Threonine; Tyrosine; Urea; Valine | 1967 |
Electron microscopic and biochemical characterization of collagen in blattarian insects.
Topics: Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Collagen; Connective Tissue Cells; Cysteine; Cystine; Female; Glutamates; Glycine; Histidine; Histocytochemistry; Hydroxyproline; Insecta; Isoleucine; Leucine; Lysine; Male; Methionine; Microscopy, Electron; Phenylalanine; Proline; Serine; Threonine; Tyrosine; Valine | 1967 |
Rapid short-column chromatography of amino acids. A method for blood and urine specimens in the diagnosis and treatment of metabolic disease.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Aminobutyrates; Autoanalysis; Buffers; Chromatography, Ion Exchange; Citrates; Cysteine; Cystine; Glutamates; Glutamine; Glycine; Humans; Hydrogen-Ion Concentration; Hydroxyproline; Isoleucine; Phenylalanine; Proline; Sarcosine; Serine; Threonine; Tyrosine; Valine | 1967 |
Gluconeogenesis from amino acids in neonatal rat liver.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartate Aminotransferases; Aspartic Acid; Gluconeogenesis; Glutamates; Glycine; Histidine; In Vitro Techniques; Leucine; Liver; Liver Glycogen; Phenylalanine; Proline; Rats; Serine; Spectrophotometry; Threonine; Tyrosine; Valine | 1967 |
Erythrocyte transfer RNA: change during chick development.
Topics: Animals; Arginine; Carbon Isotopes; Chick Embryo; Chickens; Chromatography, Ion Exchange; Erythrocytes; Leucine; Methionine; Reticulocytes; RNA, Transfer; Serine; Tyrosine | 1967 |
Site-specific mutagenesis of aspartate transcarbamoylase. Replacement of tyrosine 165 in the catalytic chain by serine reduces enzymatic activity.
Topics: Aspartate Carbamoyltransferase; Base Sequence; Binding Sites; DNA Restriction Enzymes; Escherichia coli; Kinetics; Mutation; Serine; Structure-Activity Relationship; Tyrosine | 1984 |
Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase.
Topics: Binding Sites; Cell Transformation, Neoplastic; Cell Transformation, Viral; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae; Sarcoma Viruses, Feline; Serine; Tyrosine; Viral Proteins | 1981 |
Purified low-molecular-weight protein kinase from murine sarcoma virus particles catalyzes tyrosine phosphorylation endogenously but phosphorylates cellular proteins at serine.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Transformation, Viral; Magnesium; Mice; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Proteins; Sarcoma Viruses, Murine; Serine; Tyrosine | 1981 |
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.
Topics: Amino Acids; Animals; Insulin; Liver Neoplasms, Experimental; Macromolecular Substances; Molecular Weight; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Receptor, Insulin; Serine; Tyrosine | 1982 |
Separation of phosphohydroxyamino acids by high-performance liquid chromatography.
Topics: Animals; Catalysis; Cattle; Chromatography, High Pressure Liquid; Cyclic AMP; Hydrolysis; Myelin Basic Protein; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinases; Serine; Threonine; Tyrosine | 1982 |
Two-dimensional separation of phosphoamino acids from nucleoside monophosphates.
Topics: Adenosine Monophosphate; Chromatography, Thin Layer; Cytidine Monophosphate; Electrophoresis; Escherichia coli; Guanosine Monophosphate; Nucleotides; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Thymidine Monophosphate; Tyrosine; Uracil Nucleotides; Uridine Monophosphate | 1982 |
Dansylation and high-performance liquid chromatographic separation of phosphoserine, phosphothreonine and phosphotyrosine from 32P-labeled protein hydrolyzates.
Topics: Animals; Binding Sites; Chromatography, High Pressure Liquid; Dansyl Compounds; Hydrolysis; In Vitro Techniques; Isotope Labeling; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Proteins; Rats; Serine; Threonine; Tyrosine | 1982 |
A rapid microdetermination of phosphoserine, phosphothreonine, and phosphotyrosine in proteins by automatic cation exchange on a conventional amino acid analyzer.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Hydrolysis; Myocardium; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Rats; Serine; Threonine; Tyrosine | 1983 |
Polyamide thin-layer chromatography of phosphorylated tyrosine, threonine, and serine.
Topics: Chromatography, Thin Layer; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tyrosine | 1983 |
Measurement of chemical phosphate in proteins.
Topics: Indicators and Reagents; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphotyrosine; Proteins; Radioisotope Dilution Technique; Serine; Tyrosine | 1983 |
Phosphorylation of tyrosine in cultured human placenta.
Topics: Culture Techniques; Female; Gestational Age; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Placenta; Pregnancy; Protein Kinases; Protein-Tyrosine Kinases; Serine; Threonine; Tyrosine | 1984 |
Chemical properties, isolation, and analysis of O-phosphates in proteins.
Topics: Carbon Radioisotopes; Chemical Phenomena; Chemistry; Hydrolysis; Indicators and Reagents; Phosphoproteins; Phosphorus Radioisotopes; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Threonine; Tritium; Tyrosine | 1984 |
Tyrosine phosphorylation of a 50K cellular polypeptide associated with the Rous sarcoma virus transforming protein pp60src.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Defective Viruses; Fibroblasts; Mutation; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Protein Kinases; Serine; Temperature; Tyrosine; Viral Proteins | 1982 |
Orthostatic hypotension in familial amyloid polyneuropathy: treatment with DL-threo-3,4-dihydroxyphenylserine.
Topics: Adult; Amyloidosis; Blood Pressure; Droxidopa; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Norepinephrine; Peripheral Nervous System Diseases; Serine; Tyrosine | 1981 |
Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Mutation; Oncogene Protein pp60(v-src); Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Serine; Tyrosine; Viral Proteins | 1983 |
Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis.
Topics: Antibiotics, Antineoplastic; Dihydroxyphenylalanine; Duocarmycins; Indoles; Leucomycins; Methionine; Serine; Streptomyces; Tyrosine | 1983 |
A tumor promoter stimulates phosphorylation on tyrosine.
Topics: Animals; Chick Embryo; Fibroblasts; Molecular Weight; Phorbols; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1983 |
Plasma amino acids in 3/sec spike-wave epilepsy.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aspartic Acid; Child; Child, Preschool; Epilepsy; Female; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Male; Methionine; Middle Aged; Phenylalanine; Serine; Taurine; Threonine; Tyrosine; Valine | 1980 |
The structure of hemoglobin Creteil (beta 89 Ser replaced by Asn) is similar to that of abnormal human hemoglobins having sequence changes at Tyr 145 beta.
Topics: Amino Acid Sequence; Asparagine; Hemoglobins, Abnormal; Heterozygote; Humans; Models, Molecular; Protein Conformation; Serine; Spectrophotometry; Tyrosine; X-Ray Diffraction | 1981 |
Comparison of the misreading induced by streptomycin and neomycin.
Topics: Escherichia coli; Ethylmaleimide; Isoleucine; Leucine; Neomycin; Poly U; Protein Biosynthesis; Ribosomes; Serine; Streptomycin; Tyrosine | 1981 |
Effects of amino acid precursors on catecholamine synthesis in the brain.
Topics: Amino Acids; Animals; Brain; Catecholamines; Dihydroxyphenylalanine; Droxidopa; Male; Rats; Rats, Inbred Strains; Serine; Tyrosine | 1981 |
Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro.
Topics: Amino Acid Sequence; Animals; Base Sequence; Central Nervous System; Chromosome Mapping; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Humans; Lim Kinases; Mice; Molecular Sequence Data; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Serine; Threonine; Tyrosine | 1995 |
Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.
Topics: Amino Acid Sequence; Animals; Antigens, CD; Casein Kinase II; CD4 Antigens; Cell Line; Cell Membrane; Chlorocebus aethiops; Cloning, Molecular; Cytoplasm; Furin; Golgi Apparatus; Humans; Kidney; Mice; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Restriction Mapping; Serine; Substrate Specificity; Subtilisins; Transfection; Tyrosine | 1995 |
GM3 directly inhibits tyrosine phosphorylation and de-N-acetyl-GM3 directly enhances serine phosphorylation of epidermal growth factor receptor, independently of receptor-receptor interaction.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Dogs; ErbB Receptors; Erythrocytes; G(M3) Ganglioside; Humans; Kinetics; Macromolecular Substances; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Serine; Tumor Cells, Cultured; Tyrosine | 1994 |
Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor.
Topics: 3T3 Cells; Animals; Enzyme Activation; Ethers, Cyclic; Fibroblasts; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Serine; Threonine; Tyrosine | 1994 |
Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Cell Line; ErbB Receptors; GRB2 Adaptor Protein; Humans; Membrane Proteins; Mice; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins pp60(c-src); Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface; Serine; Son of Sevenless Proteins; Tyrosine | 1994 |
A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand.
Topics: Amino Acid Sequence; Animals; Base Sequence; Casein Kinases; Cell Line; Chromatography, Affinity; Cloning, Molecular; DNA, Complementary; Glutamic Acid; Humans; Ligands; Mice; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins pp60(c-src); RNA; Sequence Homology, Amino Acid; Serine; Tyrosine | 1994 |
Hexokinase autophosphorylation: identification of a new dual specificity protein kinase.
Topics: Animals; Hexokinase; Isoenzymes; Phosphorylation; Rats; Serine; Staining and Labeling; Substrate Specificity; Threonine; Tyrosine | 1994 |
Studies into the identity of the sites of insulin-stimulated insulin receptor serine phosphorylation. Characterization of synthetic peptide substrates for the insulin-stimulated insulin receptor serine kinase.
Topics: Amino Acid Sequence; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Insulin; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphoserine; Phosphotyrosine; Placenta; Pregnancy; Receptor, Insulin; Serine; Substrate Specificity; Trypsin; Tyrosine | 1995 |
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Chlorocebus aethiops; Conserved Sequence; DNA-Binding Proteins; Gene Expression Regulation; Humans; Luciferases; Mice; Molecular Sequence Data; Phosphorylation; Phosphoserine; Phosphotyrosine; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine | 1995 |
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1.
Topics: Alkaloids; Animals; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 1995 |
Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein.
Topics: Antigens, CD; Blotting, Western; Cell Line; Cell Membrane; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Crk-Associated Substrate Protein; Cytosol; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Melanoma; Molecular Weight; Neoplasm Proteins; Oncogene Protein v-crk; Phosphoproteins; Phosphorylation; Phosphotransferases; Placenta; Proteins; Receptors, Interleukin; Receptors, Interleukin-8A; Retinoblastoma-Like Protein p130; Retroviridae Proteins, Oncogenic; Serine; Transfection; Tyrosine | 1995 |
The roles of Tyr70 and Tyr225 in aspartate aminotransferase assessed by analysing the effects of mutations on the multiple reactions of the substrate analogue serine o-sulphate.
Topics: Amination; Aspartate Aminotransferases; Methionine; Mutation; Phenylalanine; Serine; Structure-Activity Relationship; Tyrosine | 1995 |
The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.
Topics: Amino Acid Sequence; Binding Sites; Cells, Cultured; Cysteine; Disulfides; Extracellular Matrix; Glycine; Humans; Kinetics; Ligands; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Receptors, Glycine; Serine; Strychnine; Taurine; Threonine; Tyrosine | 1995 |
Rapid phosphorylation and selective dephosphorylation of P-selectin accompanies platelet activation.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Collagen; Epinephrine; Humans; Kinetics; Molecular Sequence Data; Oligopeptides; P-Selectin; Phosphorylation; Platelet Activation; Platelet Membrane Glycoproteins; Serine; Threonine; Thrombin; Tyrosine | 1993 |
Requirement of serine phosphorylation for formation of STAT-promoter complexes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cell Nucleus; Ciliary Neurotrophic Factor; Cytoplasm; DNA; DNA-Binding Proteins; Humans; Interleukin-6; Isoquinolines; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Phosphorylation; Piperazines; Promoter Regions, Genetic; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Threonine; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 1995 |
Monoclonal antibodies as site-specific probes for the acetylcholine-receptor delta-subunit tyrosine and serine phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Epitope Mapping; Molecular Sequence Data; Phosphorylation; Rats; Receptors, Cholinergic; Serine; Torpedo; Tyrosine | 1995 |
Platelet talin is phosphorylated by calyculin A.
Topics: Alkalies; Antibodies, Monoclonal; Blood Platelets; Electrophoresis, Polyacrylamide Gel; Humans; Isotope Labeling; Marine Toxins; Oxazoles; Peptides; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Precipitin Tests; Serine; Talin; Threonine; Tyrosine | 1995 |
Structure of the complex of L-benzylsuccinate with wheat serine carboxypeptidase II at 2.0-A resolution.
Topics: Amino Acid Sequence; Binding Sites; Carboxypeptidases; Computer Graphics; Crystallography, X-Ray; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Serine; Succinates; Thermodynamics; Triticum; Tyrosine | 1994 |
Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.
Topics: Amino Acid Sequence; Base Sequence; Centrosome; Genes, Fungal; Genes, Lethal; Genomic Library; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine; Substrate Specificity; Threonine; Tyrosine | 1995 |
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
Topics: Binding Sites; Blood Platelets; Cell Line; Cytoskeleton; GTP-Binding Proteins; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Megakaryocytes; Pertussis Toxin; Phosphorylation; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Thrombin; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1995 |
Computer modelling of the alpha-helical coiled coil: packing of side-chains in the inner core.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Computer Simulation; Cysteine; Glutamates; Glutamine; Histidine; Hydrogen Bonding; Isoleucine; Leucine; Lysine; Methionine; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Serine; Thermodynamics; Threonine; Tyrosine; Valine | 1995 |
Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages.
Topics: Amino Acids; Cell Differentiation; DNA-Binding Proteins; Gene Expression Regulation; Interferon-Stimulated Gene Factor 3; Janus Kinase 1; Janus Kinase 2; Macrophages; Models, Biological; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Serine; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 1995 |
An RNA-protein contact determined by 5-bromouridine substitution, photocrosslinking and sequencing.
Topics: Amino Acid Sequence; Base Sequence; Bromouracil; Capsid; Capsid Proteins; Cross-Linking Reagents; Molecular Sequence Data; Nucleic Acid Conformation; RNA-Binding Proteins; RNA-Dependent RNA Polymerase; RNA, Viral; Sequence Analysis; Serine; Tyrosine; Ultraviolet Rays; Uridine | 1994 |
Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores.
Topics: Amino Acid Sequence; Base Sequence; Calcium Channels; Cardiomyopathy, Hypertrophic; Chromosomes, Human, Pair 19; DNA Mutational Analysis; Female; Genes; Genetic Linkage; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Malignant Hyperthermia; Molecular Sequence Data; Muscle Proteins; Myopathies, Nemaline; Pedigree; Point Mutation; Polymorphism, Single-Stranded Conformational; Ryanodine Receptor Calcium Release Channel; Serine; Tyrosine | 1994 |
Tyrosine phosphorylation of measles virus nucleocapsid protein in persistently infected neuroblastoma cells.
Topics: 2',5'-Oligoadenylate Synthetase; Capsid; eIF-2 Kinase; Humans; Measles virus; Neuroblastoma; Nucleocapsid Proteins; Nucleoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Threonine; Tumor Cells, Cultured; Tyrosine; Viral Proteins | 1995 |
Properties of tyrosine 766-->serine mutant of Escherichia coli DNA polymerase I: template-specific effects.
Topics: Base Sequence; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; DNA Adducts; DNA Polymerase I; DNA Primers; Escherichia coli; Molecular Sequence Data; Mutation; Serine; Substrate Specificity; Thymine Nucleotides; Tyrosine; Ultraviolet Rays | 1994 |
Stage-specific regulation of protein phosphorylation in Leishmania major.
Topics: Animals; In Vitro Techniques; Leishmania major; Molecular Weight; Phosphorylation; Protein Kinases; Protozoan Proteins; Serine; Signal Transduction; Threonine; Tyrosine | 1994 |
An assessment of progression of brain edema with amino acid levels in cerebrospinal fluid and changes in electroencephalogram in an adult cat model of cold brain injury.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cats; Electroencephalography; Evoked Potentials; Freezing; Glutamic Acid; Methionine; Motor Cortex; Phenylalanine; Serine; Synaptic Transmission; Tyrosine; Valine | 1994 |
Biochemical characterization of the boar sperm 42 kilodalton protein tyrosine kinase: its potential for tyrosine as well as serine phosphorylation towards microtubule-associated protein 2 and histone H 2B.
Topics: Amino Acid Sequence; Animals; Histones; Male; Microtubule-Associated Proteins; Molecular Sequence Data; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Signal Transduction; Spermatozoa; Substrate Specificity; Swine; Tyrosine | 1994 |
B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.
Topics: Adaptor Proteins, Signal Transducing; Animals; GRB2 Adaptor Protein; Membrane Proteins; Mice; Mice, Inbred DBA; Phosphoproteins; Phosphorylation; Proteins; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, B-Cell; Serine; Son of Sevenless Proteins; Tumor Cells, Cultured; Tyrosine | 1994 |
Serine-rich region of the IL-2 receptor beta-chain is required for activation of phosphatidylinositol 3-kinase.
Topics: Amino Acid Sequence; Animals; Cell Line; Enzyme Activation; Gene Expression; Humans; Interleukin-2; Molecular Sequence Data; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Receptors, Interleukin-2; Serine; Signal Transduction; Tyrosine | 1994 |
Interaction of mammalian sperm nuclear protamines and peptides derived thereof with immobilized zinc.
Topics: Amino Acid Sequence; Animals; Cell Nucleus; Chromatography, Affinity; Cysteine; Histidine; Humans; Male; Molecular Sequence Data; Peptides; Protamines; Serine; Sheep; Spermatozoa; Swine; Tyrosine; Zinc | 1994 |
Stimulation of tyrosine- and serine-phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cattle; Cell Adhesion Molecules; Cells, Cultured; Cross-Linking Reagents; Fibroblast Growth Factors; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptors, Fibroblast Growth Factor; Serine; Tyrosine | 1994 |
Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor.
Topics: Angiotensin II; Animals; Autoradiography; Cells, Cultured; Colforsin; Immunoblotting; Ionomycin; Male; Muscle, Smooth, Vascular; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Anti-CD2-induced tyrosine phosphorylation of T cell polypeptides is independent of the PMA-induced modification of p56lck.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Arsenicals; CD2 Antigens; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mitosis; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Immunologic; Serine; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Preferential beta-hexosaminidase (Hex) A (alpha beta) formation in the absence of beta-Hex B (beta beta) due to heterozygous point mutations present in beta-Hex beta-chain alleles of a motor neuron disease patient.
Topics: Adult; Alleles; Amino Acid Sequence; Animals; beta-N-Acetylhexosaminidases; Cell Line; Exons; Female; Genetic Carrier Screening; Hexosaminidase A; Hexosaminidase B; Humans; Macromolecular Substances; Male; Motor Neuron Disease; Point Mutation; Protein Structure, Secondary; Sandhoff Disease; Serine; Transfection; Tyrosine | 1994 |
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Topics: 3T3 Cells; Adipocytes; Animals; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, Insulin; Serine; Signal Transduction; Threonine; Tyrosine | 1994 |
Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.
Topics: Animals; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Protozoan Proteins; Serine; Trypanosoma brucei brucei; Tyrosine | 1994 |
The insulin receptor: a protein kinase with dual specificity?
Topics: Electrophoresis, Polyacrylamide Gel; Humans; Phosphorylation; Placenta; Protein Kinases; Receptor, Insulin; Serine; Substrate Specificity; Tyrosine | 1994 |
Insulin receptor mutation at tyrosines 1162 and 1163 alters both receptor serine phosphorylation and desensitization.
Topics: Animals; CHO Cells; Cricetinae; Desensitization, Immunologic; Glycogen; Humans; Insulin; Mutation; Phosphorylation; Protein Kinase C; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1994 |
Role of hydroxyl-bearing amino acids in differentially tuning the absorption spectra of the human red and green cone pigments.
Topics: Cell Line; Humans; Light; Models, Molecular; Mutagenesis, Site-Directed; Photoreceptor Cells; Polymorphism, Genetic; Recombinant Proteins; Retinal Pigments; Serine; Spectrophotometry; Threonine; Transfection; Tyrosine | 1993 |
Glycosylation of two recombinant human uterine tissue plasminogen activator variants carrying an additional N-glycosylation site in the epidermal-growth-factor-like domain.
Topics: Amino Acid Sequence; Asparagine; Base Sequence; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Female; Genetic Variation; Glycine; Glycopeptides; Glycosylation; Humans; Mass Spectrometry; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oligosaccharides; Peptide Mapping; Protein Processing, Post-Translational; Recombinant Proteins; Serine; Tissue Plasminogen Activator; Tyrosine; Uterus | 1994 |
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphorylation; Protein Kinase C; Protein Kinases; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1993 |
Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Androgens; Animals; Base Sequence; Chorionic Gonadotropin; Cloning, Molecular; DNA; Escherichia coli; Gene Expression; Humans; Infant; Liver; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; NADPH-Ferrihemoprotein Reductase; Plasmids; Point Mutation; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Steroid 17-alpha-Hydroxylase; Steroids; Testis; Tyrosine | 1993 |
Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine.
Topics: Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Glycogen Synthase Kinase 3; Phosphorylation; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Substrate Specificity; Threonine; Tyrosine | 1993 |
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Mice; Phosphorylation; Proteins; Receptor, Insulin; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1993 |
The mechanism of action of DD-peptidases: the role of tyrosine-159 in the Streptomyces R61 DD-peptidase.
Topics: Anti-Bacterial Agents; Base Sequence; Chemical Phenomena; Chemistry, Physical; Enzyme Stability; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Lactams; Molecular Sequence Data; Muramoylpentapeptide Carboxypeptidase; Mutagenesis; Phenylalanine; Plasmids; Recombinant Proteins; Serine; Streptomyces; Structure-Activity Relationship; Tyrosine | 1993 |
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
Topics: Amino Acid Sequence; Animals; Cell Membrane; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Electrophoresis, Polyacrylamide Gel; Humans; Insulin; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphopeptides; Phosphorylation; Receptor, Insulin; Recombinant Proteins; Serine; Transfection; Tyrosine | 1993 |
Epidermal growth factor induces serine phosphorylation of stathmin in a human colon carcinoma cell line (LIM 1215).
Topics: Amino Acid Sequence; Base Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Humans; Microtubule Proteins; Molecular Sequence Data; Oligonucleotides, Antisense; Peptide Mapping; Phosphoproteins; Phosphorylation; Serine; Stathmin; Tumor Cells, Cultured; Tyrosine | 1993 |
Isoproterenol inhibits insulin-stimulated tyrosine phosphorylation of the insulin receptor without increasing its serine/threonine phosphorylation.
Topics: Adenosine Triphosphate; Adipocytes; Adrenergic beta-Agonists; Animals; Cells, Cultured; Female; Hydrogen-Ion Concentration; Insulin; Insulin Antagonists; Isoproterenol; Peptide Mapping; Phosphorylation; Rats; Rats, Wistar; Receptor, Insulin; Serine; Threonine; Tyrosine | 1995 |
Autosomal dominant cone-rod dystrophy associated with mutations in codon 244 (Asn244His) and codon 184 (Tyr184Ser) of the peripherin/RDS gene.
Topics: Adult; Aged; Amino Acid Sequence; Asparagine; Base Sequence; Codon; DNA; Electroretinography; Eye Proteins; Female; Fluorescein Angiography; Histidine; Humans; Intermediate Filament Proteins; Male; Membrane Glycoproteins; Middle Aged; Molecular Sequence Data; Nerve Tissue Proteins; Pedigree; Peripherins; Photoreceptor Cells; Point Mutation; Polymorphism, Single-Stranded Conformational; Retinal Degeneration; Serine; Tyrosine; Visual Fields | 1996 |
Effect of serine O-glycosylation on cis-trans proline isomerization.
Topics: Acetylglucosamine; Amino Acid Sequence; Glycopeptides; Glycosylation; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligopeptides; Proline; Protein Conformation; Serine; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 1996 |
Delocalizing trypsin specificity with metal activation.
Topics: Amino Acid Sequence; Aprotinin; Bacterial Proteins; Base Sequence; Computer Simulation; Crystallography, X-Ray; Escherichia coli Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Periplasmic Proteins; Serine; Substrate Specificity; Trypsin; Tyrosine | 1996 |
Identification of insulin-stimulated phosphorylation sites on calmodulin.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calmodulin; Casein Kinase II; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Insulin; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Insulin; Recombinant Proteins; Serine; Threonine; Tyrosine | 1996 |
Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.
Topics: Animals; Base Sequence; Cell Line, Transformed; Cells, Cultured; DNA Primers; Mice; Mitogens; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptor, IGF Type 1; Serine; Signal Transduction; Substrate Specificity; Tumor Cells, Cultured; Tyrosine | 1996 |
Substrates containing phosphorylated residues adjacent to proline decrease the cleavage by proline-specific peptidases.
Topics: Amino Acid Sequence; Anilides; Aniline Compounds; Animals; Dipeptides; Endopeptidases; Flavobacterium; Humans; Hydrolysis; Kinetics; Molecular Conformation; Molecular Sequence Data; Oligopeptides; Phosphorylation; Proline; Prolyl Oligopeptidases; Protease Inhibitors; Serine; Serine Endopeptidases; Substrate Specificity; Swine; Threonine; Tyrosine | 1996 |
Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.
Topics: Base Sequence; Cell Line; DNA-Binding Proteins; Humans; Interleukin-12; Interleukin-2; Janus Kinase 1; Killer Cells, Natural; Lymphocyte Activation; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrosine | 1996 |
Analysis of phosphorylation and mutation of tyrosine residues of calmodulin on its activation of the erythrocyte Ca(2+)-transporting ATPase.
Topics: Animals; Calcium-Transporting ATPases; Calmodulin; Enzyme Activation; Erythrocyte Membrane; Humans; Mutation; Phosphorylation; Serine; Swine; Threonine; Tyrosine | 1996 |
Protein engineering studies of dichloromethane dehalogenase/glutathione S-transferase from Methylophilus sp. strain DM11. Ser12 but not Tyr6 is required for enzyme activity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Chickens; DNA Primers; Fishes; Genes, Bacterial; Glutathione Transferase; Gram-Negative Aerobic Bacteria; Humans; Kinetics; Lyases; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Engineering; Protein Structure, Secondary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Tyrosine | 1996 |
The role of the T-loop of the signal transducing protein PII from Escherichia coli.
Topics: Amino Acid Sequence; Bacteria; Bacterial Proteins; Base Sequence; Crystallography, X-Ray; DNA Primers; Escherichia coli; Kinetics; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; PII Nitrogen Regulatory Proteins; Plasmids; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Software; Tyrosine; UDPglucose-Hexose-1-Phosphate Uridylyltransferase; Uridine | 1996 |
Unaccustomed high-mileage vs intensity training-related changes in performance and serum amino acid levels.
Topics: Adult; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cystine; Erythrocyte Count; Exercise Test; Fatigue; Glycine; Hematocrit; Hemoglobins; Humans; Lactates; Leukocyte Count; Lysine; Methionine; Phenylalanine; Physical Endurance; Prospective Studies; Running; Serine; Taurine; Tryptophan; Tyrosine | 1996 |
Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extracellular signal-dependent inactivation.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; CHO Cells; Cricetinae; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Insulin; Molecular Sequence Data; Phosphorylation; Serine; Signal Transduction; Tyrosine | 1996 |
Determination of the Neurospora crassa CYS 3 sulfur regulatory protein consensus DNA-binding site: amino-acid substitutions in the CYS3 bZIP domain that alter DNA-binding specificity.
Topics: Amino Acid Sequence; Conserved Sequence; Cystathionine gamma-Lyase; DNA-Binding Proteins; DNA, Fungal; Mutagenesis, Site-Directed; Mutation; Neurospora crassa; Phenylalanine; Saccharomyces cerevisiae Proteins; Serine; Transcription Factors; Tyrosine | 1996 |
Reciprocal modulation of ATP-sensitive K+ channel activity in rat ventricular myocytes by phosphorylation of tyrosine and serine/threonine residues.
Topics: Adenosine Triphosphate; Animals; Myocardium; Phosphorylation; Potassium Channels; Rats; Rats, Sprague-Dawley; Serine; Threonine; Time Factors; Tyrosine | 1996 |
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
Topics: Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Catalysis; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Estradiol; Estradiol Dehydrogenases; Estrone; Female; Humans; Macromolecular Substances; Models, Molecular; Molecular Conformation; Molecular Sequence Data; NADP; Oxidation-Reduction; Oxygen; Placenta; Protein Binding; Protein Conformation; Recombinant Proteins; Serine; Substrate Specificity; Temperature; Tyrosine | 1996 |
Complementarity determining region residues aspartic acid at H55, serine at H95 and tyrosines at H97 and L96 play important roles in the B72.3 antibody-TAG72 antigen interaction.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Affinity; Antigen-Antibody Reactions; Antigens, Neoplasm; Aspartic Acid; Binding Sites, Antibody; Glycoproteins; Humans; Hydrogen Bonding; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Fusion Proteins; Serine; Tyrosine | 1996 |
Additivity of apparent and true ileal amino acid digestibilities in soybean meal, sunflower meal, and meat and bone meal for broilers.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Biological Products; Chickens; Digestion; Female; Glutamic Acid; Glycine max; Helianthus; Homoarginine; Ileum; Isoleucine; Meat; Minerals; Predictive Value of Tests; Serine; Tyrosine | 1996 |
Ser-27, Tyr-10 and Tyr-7 in the alpha-chain of pig stomach H+,K(+)-ATPase as Ca(2+)-dependent phosphorylatable sites by intrinsic and extrinsic protein kinases.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; H(+)-K(+)-Exchanging ATPase; Molecular Sequence Data; Phosphorylation; Protein Kinases; Serine; Stomach; Swine; Tyrosine | 1996 |
Molecular modeling of the interaction of anthracenyl-amino acid topoisomerase inhibitors with the DNA sequence d(CGTACG).
Topics: Amino Acids; Anthraquinones; Arginine; DNA; Enzyme Inhibitors; Models, Molecular; Serine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tyrosine | 1996 |
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Breast Neoplasms; CHO Cells; Cricetinae; Estradiol; Histone Acetyltransferases; Humans; Molecular Sequence Data; Mutation; Nuclear Receptor Coactivator 1; Phenotype; Phosphorylation; Receptors, Estrogen; Recombinant Proteins; Serine; Structure-Activity Relationship; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1996 |
Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor.
Topics: Adenylyl Cyclases; Bradykinin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Humans; Isoproterenol; Oncogene Proteins; Phosphorylation; Serine; Threonine; Tumor Cells, Cultured; Tyrosine | 1996 |
Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.
Topics: Animals; Base Sequence; Cells, Cultured; COS Cells; DNA; DNA-Binding Proteins; Humans; Interferon Type I; Interleukin-12; Killer Cells, Natural; Ligands; Oligodeoxyribonucleotides; Phosphorylation; Protein Binding; Recombinant Proteins; Serine; STAT4 Transcription Factor; T-Lymphocytes; Trans-Activators; Tyrosine | 1996 |
Serine/threonine dephosphorylation may be involved in tyrosine phosphorylation: a new mode of signal transduction in platelets.
Topics: Blood Platelets; Humans; Okadaic Acid; Phosphorylation; Platelet Aggregation; Serine; Signal Transduction; Threonine; Tyrosine | 1996 |
Is raf-1 the 74 kDa signalling molecule in neutrophils?
Topics: Enzyme Activation; Neutrophils; Oxidoreductases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Serine; Tyrosine | 1995 |
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cell Line; Electrophoresis, Gel, Two-Dimensional; ErbB Receptors; GRB2 Adaptor Protein; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Mutagenesis; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Rabbits; Serine; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Threonine; Tyrosine | 1996 |
The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.
Topics: Animals; Biological Transport; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Phosphatase 1; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tyrosine | 1996 |
The neural adhesion molecule L1 is phosphorylated on tyrosine and serine residues.
Topics: Animals; Autoradiography; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Cerebellum; Mice; Mice, Inbred Strains; Serine; Tyrosine | 1996 |
Varicella-zoster virus Fc receptor gE glycoprotein: serine/threonine and tyrosine phosphorylation of monomeric and dimeric forms.
Topics: Animals; Binding Sites; Casein Kinase II; Cell Line; Consensus Sequence; Dimerization; Gene Expression; Glycosylation; HeLa Cells; Herpesvirus 3, Human; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Fc; Recombinant Fusion Proteins; Serine; Spodoptera; Threonine; Tyrosine; Viral Envelope Proteins | 1997 |
Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Binding Sites; Chitin Synthase; Farnesyltranstransferase; Fungal Proteins; Geranyltranstransferase; Molecular Sequence Data; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Serine; Structure-Activity Relationship; Substrate Specificity; Transferases; Tyrosine | 1997 |
Identification of potential tyrosine-containing endocytic motifs in the carboxyl-tail and seventh transmembrane domain of the neurokinin 1 receptor.
Topics: Amino Acid Sequence; Animals; Endocytosis; Fluorescent Antibody Technique, Indirect; Microscopy, Confocal; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Receptors, Neurokinin-1; Serine; Threonine; Tyrosine | 1997 |
Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons.
Topics: Animals; Cell Membrane; Cells, Cultured; Female; Hippocampus; Neurons; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Threonine; Tyrosine | 1997 |
Tyrosine phosphorylation of measles virus P-phosphoprotein in persistently infected neuroblastoma cells.
Topics: Animals; CSK Tyrosine-Protein Kinase; Measles virus; Mice; Neuroblastoma; Phosphoproteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Serine; src-Family Kinases; Threonine; Tumor Cells, Cultured; Tyrosine; Viral Proteins; Virus Latency | 1996 |
Site-directed mutagenesis of the aspartokinase gene lysC and its characterization in Brevibacterium flavum.
Topics: Aspartate Kinase; Brevibacterium; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Mutagenesis, Site-Directed; Phenylalanine; Plasmids; Polymerase Chain Reaction; Sequence Analysis, DNA; Serine; Transformation, Genetic; Tyrosine | 1997 |
The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity.
Topics: Amino Acid Sequence; Animals; Conserved Sequence; Crystallography, X-Ray; Diethyl Pyrocarbonate; Dipeptides; Genetic Complementation Test; Hypoxanthine Phosphoribosyltransferase; Indicators and Reagents; Kinetics; Leishmania donovani; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylcholines; Protein Conformation; Sequence Alignment; Serine; Tetranitromethane; Tyrosine | 1997 |
Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; Binding Sites; Carcinogens; COS Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Jurkat Cells; Mice; Molecular Sequence Data; Oncogene Protein v-cbl; Peptide Mapping; Phorbol Esters; Phosphorylation; Protein Conformation; Protein-Tyrosine Kinases; Proteins; Rabbits; Receptor-CD3 Complex, Antigen, T-Cell; Retroviridae Proteins, Oncogenic; Serine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Tyrosine 3-Monooxygenase | 1997 |
The conserved residue tyrosine 34 is essential for maximal activity of iron-superoxide dismutase from Escherichia coli.
Topics: Amino Acid Sequence; Conserved Sequence; Cysteine; Escherichia coli; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Restriction Mapping; Serine; Structure-Activity Relationship; Superoxide Dismutase; Tyrosine | 1997 |
Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
Topics: Cell Line; DNA-Binding Proteins; Humans; Lymphocytes; Milk Proteins; Phosphorylation; Prolactin; Protein Binding; Serine; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 1997 |
Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the mu2 subunit of the AP2 clathrin adaptor complex.
Topics: Adaptor Protein Complex 1; Adaptor Protein Complex 2; Adaptor Protein Complex 3; Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex mu Subunits; Adaptor Proteins, Vesicular Transport; Binding Sites; Glycoproteins; Membrane Glycoproteins; Membrane Proteins; Protein Binding; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Serine; Tyrosine | 1997 |
The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.
Topics: Adenosine Triphosphate; Animals; Baculoviridae; Cloning, Molecular; Escherichia coli; Humans; Luciferases; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Serine; Spodoptera; Threonine; Transfection; Tyrosine | 1997 |
Microdialysis of human breast tissue during the menstrual cycle.
Topics: Adipose Tissue; Adult; Amino Acids; Asparagine; Aspartic Acid; Breast; Chromatography, High Pressure Liquid; Female; Glycine; Humans; Lactic Acid; Menstrual Cycle; Microdialysis; Ornithine; Pyruvic Acid; Serine; Threonine; Tyrosine | 1997 |
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1997 |
Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Cytoplasm; Dogs; Gene Products, env; Glycoproteins; HIV-1; Human T-lymphotropic virus 1; Humans; Jurkat Cells; Mice; Molecular Sequence Data; Moloney murine leukemia virus; Phenylalanine; Point Mutation; Serine; Tyrosine | 1997 |
Transcriptional regulation of Sertoli cell immediate early genes by interleukin-6 and interferon-gamma is mediated through phosphorylation of STAT-3 and STAT-1 proteins.
Topics: Animals; Antineoplastic Agents; DNA; DNA-Binding Proteins; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Genistein; Interferon-gamma; Interleukin-6; Isoflavones; Male; Models, Molecular; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA; Serine; Sertoli Cells; STAT1 Transcription Factor; STAT3 Transcription Factor; Threonine; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tyrosine | 1997 |
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Transformation, Neoplastic; COS Cells; Enzyme Activation; Fibroblasts; Genes, ras; Genes, src; Molecular Sequence Data; Mutation; Peptide Fragments; Peptide Mapping; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Recombinant Fusion Proteins; Serine; Signal Transduction; Tyrosine | 1997 |
The role of cysteine residues in the homeodomain protein Mat alpha 2 in mating-type control of Saccharomyces cerevisiae.
Topics: Cysteine; Dimerization; Fungal Proteins; Homeodomain Proteins; Mutation; Receptors, Mating Factor; Receptors, Peptide; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sulfides; Transcription Factors; Transformation, Genetic; Tyrosine | 1997 |
Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.
Topics: Bacterial Proteins; Catalysis; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Genes, Bacterial; Genes, Synthetic; Kinetics; Mutagenesis, Insertional; Protein Conformation; Protein Engineering; Serine; Tyrosine; UDPglucose 4-Epimerase | 1997 |
Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway.
Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Insulin; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 1997 |
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Cell Line; DNA Primers; Humans; Insulin Receptor Substrate Proteins; Kidney; Kinetics; Liver; Mice; Mice, Obese; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein Kinase C; Receptor, Insulin; Recombinant Proteins; Sequence Tagged Sites; Serine; Transfection; Tyrosine | 1997 |
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; COS Cells; DNA-Binding Proteins; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Substrate Specificity; Trans-Activators; Tyrosine | 1997 |
Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase.
Topics: 3T3 Cells; Animals; DNA-Binding Proteins; Enzyme Activation; Interferon-gamma; Janus Kinase 2; Mice; Peptide Mapping; Phosphoamino Acids; Phosphopeptides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine | 1997 |
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases. Investigation of Ser-9 and Tyr-113 in a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.
Topics: Animals; Binding Sites; Catalysis; Diptera; Glutathione Transferase; Hydrogen-Ion Concentration; Hydroxyl Radical; Kinetics; Serine; Temperature; Tyrosine; Viscosity | 1997 |
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Alanine; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Insulin; Insulin-Like Growth Factor I; Isoenzymes; Mutagenesis, Site-Directed; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Recombinant Proteins; Serine; Transfection; Tyrosine | 1997 |
Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Humans; Insulin Receptor Substrate Proteins; Kidney; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
The universal stress protein, UspA, of Escherichia coli is phosphorylated in response to stasis.
Topics: Amino Acid Sequence; Bacterial Proteins; Escherichia coli; Heat-Shock Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Serine; Threonine; Transcription, Genetic; Tyrosine | 1997 |
Phosphorylation of Tyr7, Tyr10, and Ser27 of alpha-chain in H+,K(+)-ATPase by intrinsic and extrinsic kinases.
Topics: Animals; Cholic Acids; Detergents; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Kinetics; Macromolecular Substances; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinases; Serine; Swine; Tyrosine | 1997 |
Residue 116 determines the C-terminal anchor residue of HLA-B*3501 and -B*5101 binding peptides but does not explain the general affinity difference.
Topics: Binding Sites; Cell Line; HLA-B Antigens; HLA-B35 Antigen; HLA-B51 Antigen; Humans; Methionine; Mutagenesis, Site-Directed; Peptides; Phenylalanine; Serine; Transfection; Tyrosine | 1998 |
Conversion of forskolin-insensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Colforsin; DNA Mutational Analysis; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gs; Mice; Models, Molecular; Point Mutation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Species Specificity; Structure-Activity Relationship; Tyrosine | 1998 |
Analytical and ultrastructural studies of pellicle on primary teeth.
Topics: Amino Acids; Child; Dental Deposits; Dental Enamel; Dental Pellicle; Dentition, Mixed; Electron Probe Microanalysis; Glycine; Humans; Microscopy, Electron; Proteins; Serine; Tooth; Tooth, Deciduous; Tyrosine | 1997 |
Characterization of a buried neutral histidine in Bacillus circulans xylanase: internal dynamics and interaction with a bound water molecule.
Topics: Bacillus; Deuterium; Histidine; Hydrogen; Hydrogen-Ion Concentration; Hydroxides; Kinetics; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Protein Binding; Serine; Tyrosine; Water; Xylan Endo-1,3-beta-Xylosidase; Xylosidases | 1998 |
Investigation of the potential active site of a cyanide dihydratase using site-directed mutagenesis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding Sites; Cysteine; Hydrolases; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenylalanine; Pseudomonas; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine; Tyrosine | 1998 |
Alteration of the midpoint potential and catalytic activity of the rieske iron-sulfur protein by changes of amino acids forming hydrogen bonds to the iron-sulfur cluster.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Catalysis; Cattle; Computer Simulation; Disulfides; Electron Transport Complex III; Hydrogen Bonding; Iron; Iron-Sulfur Proteins; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Structure, Secondary; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Alignment; Serine; Sulfur; Tyrosine | 1998 |
Tyrosine and serine phosphorylation of the neural cell adhesion molecule L1 is implicated in its oligomannosidic glycan dependent association with NCAM and neurite outgrowth.
Topics: Amino Acid Sequence; Animals; Brain; Carbohydrate Metabolism; Cell Division; Cell Membrane; Cells, Cultured; Leukocyte L1 Antigen Complex; Mice; Molecular Sequence Data; Neural Cell Adhesion Molecules; Neurites; Neurons; Oligopeptides; Oligosaccharides; Peptides; Phosphorylation; Serine; Tyrosine | 1998 |
Mutations to alter Aspergillus awamori glucoamylase selectivity. I. Tyr48Phe49-->Trp, Tyr116-->Trp, Tyr175-->Phe, Arg241-->Lys, Ser411-->Ala and Ser411-->Gly.
Topics: Arginine; Aspergillus; Binding Sites; Carbohydrate Conformation; Catalysis; Glucan 1,4-alpha-Glucosidase; Glucose; Hydrolysis; Isomaltose; Kinetics; Molecular Structure; Mutagenesis, Site-Directed; Polysaccharides; Serine; Structure-Activity Relationship; Thermodynamics; Tyrosine | 1998 |
Resistance gene N-mediated de novo synthesis and activation of a tobacco mitogen-activated protein kinase by tobacco mosaic virus infection.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Induction; Mitogen-Activated Protein Kinases; Molecular Weight; Nicotiana; Plant Proteins; Plants, Toxic; Protein Kinases; RNA, Messenger; Serine; Threonine; Tobacco Mosaic Virus; Tyrosine | 1998 |
Tyrosine and tryptophan act through the same binding site at the dimer interface of yeast chorismate mutase.
Topics: Allosteric Regulation; Binding Sites; Chorismate Mutase; Codon; Dimerization; Glycine; Models, Chemical; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Serine; Threonine; Tryptophan; Tyrosine | 1998 |
Active-site binding of glycosides by Thermomonospora fusca endocellulase E2.
Topics: Actinomycetales; Bacterial Proteins; Binding Sites; Calorimetry; Cellobiose; Cellulase; Glucose; Glucosides; Glycosides; Hydrogen-Ion Concentration; Hymecromone; Kinetics; Ligands; Mutagenesis, Site-Directed; Phenylalanine; Serine; Spectrometry, Fluorescence; Thermodynamics; Titrimetry; Tyrosine | 1998 |
Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation.
Topics: Animals; Antibodies; Antibody Specificity; Cell Line; DNA-Binding Proteins; Enzyme Activation; Humans; Interferon gamma Receptor; Interferon-gamma; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Mice; Mitogens; Phosphorylation; Rabbits; Receptors, Interferon; Salmonella typhimurium; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1998 |
Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K.
Topics: Alkylation; Amino Acid Substitution; Animals; Binding Sites; Biopolymers; Catalysis; Cattle; Enzyme Activation; Humans; Hydrolysis; Ligases; Mutagenesis, Site-Directed; Peptide Fragments; Phenotype; Point Mutation; Polyubiquitin; Protein Structure, Tertiary; Rabbits; Serine; Structure-Activity Relationship; Trypsin; Tyrosine; Ubiquitin-Conjugating Enzymes; Ubiquitins | 1998 |
Dual amino acid-selective and site-directed stable-isotope labeling of the human c-Ha-Ras protein by cell-free synthesis.
Topics: Amino Acids; Aspartic Acid; Binding Sites; Carbon Isotopes; Carbon Radioisotopes; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Humans; Isotope Labeling; Models, Chemical; Mutagenesis, Site-Directed; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Oncogene Proteins v-raf; Proline; ras Proteins; Retroviridae Proteins, Oncogenic; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Tyrosine | 1998 |
Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli.
Topics: Alanine; Binding Sites; Crystallography, X-Ray; Escherichia coli; Models, Molecular; Mutagenesis, Insertional; NAD; Phenylalanine; Serine; Tyrosine; UDPglucose 4-Epimerase; Uridine Diphosphate Galactose; Uridine Diphosphate Glucose | 1998 |
Roles of the Ser146, Tyr159, and Lys163 residues in the catalytic action of 7alpha-hydroxysteroid dehydrogenase from Escherichia coli.
Topics: Binding Sites; Catalysis; DNA Primers; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydroxysteroid Dehydrogenases; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Recombinant Proteins; Serine; Tyrosine | 1998 |
Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Enzyme Activation; Glucose; Glucose Transporter Type 4; Insulin; Insulin Antagonists; Insulin Receptor Substrate Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Serine; Threonine; Tyrosine | 1998 |
Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cattle; Circular Dichroism; Glycine; Hirudins; Humans; Molecular Sequence Data; Peptide Fragments; Phenylalanine; Serine; Spectrometry, Fluorescence; Thrombin; Tyrosine; Valine | 1998 |
Role of active site tyrosine residues in catalysis by human glutathione reductase.
Topics: Amino Acid Substitution; Binding Sites; Catalysis; Electron Transport; Enzyme Activation; Fluorescence Polarization; Glutathione; Glutathione Reductase; Humans; Leucine; NADP; Oxidation-Reduction; Serine; Spectrometry, Fluorescence; Tyrosine | 1998 |
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression Regulation; Guanosine Triphosphate; Molecular Sequence Data; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Allostery in rabbit pyruvate kinase: development of a strategy to elucidate the mechanism.
Topics: Allosteric Regulation; Animals; Binding Sites; Circular Dichroism; Energy Metabolism; Kidney; Kinetics; Lysine; Mathematical Computing; Models, Molecular; Muscle, Skeletal; Mutagenesis, Site-Directed; Phenylalanine; Proline; Protein Conformation; Protein Structure, Secondary; Pyruvate Kinase; Rabbits; Recombinant Proteins; Serine; Structure-Activity Relationship; Tyrosine; Ultracentrifugation | 1998 |
Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites.
Topics: Alanine; Amino Acid Substitution; Insulin Receptor Substrate Proteins; Isoenzymes; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Tyrosine; Yeasts | 1998 |
Engagement of ICAM-3 activates polymorphonuclear leukocytes: aggregation without degranulation or beta 2 integrin recruitment.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Calcium; Cell Adhesion Molecules; Cell Aggregation; Cell Degranulation; Cytoplasmic Granules; Cytoskeleton; Epitopes; Humans; Intracellular Fluid; Lymphocyte Function-Associated Antigen-1; Neutrophil Activation; Neutrophils; Phosphorylation; Receptor Aggregation; Serine; Signal Transduction; Tyrosine | 1998 |
Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein.
Topics: Adenine Phosphoribosyltransferase; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Enzyme Activation; Glutamic Acid; Guanine; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Isoleucine; Lysine; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Purines; Ribonucleotides; Serine; Structure-Activity Relationship; Substrate Specificity; Tritrichomonas foetus; Tyrosine; Xanthine | 1998 |
Conversion of bovine pancreatic DNase I to a repair endonuclease with a high selectivity for abasic sites.
Topics: Animals; Base Sequence; Carbon-Oxygen Lyases; Cattle; Deoxyribonuclease I; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Exodeoxyribonucleases; Exonucleases; Gene Expression; Hydrolysis; Molecular Sequence Data; Mutagenesis, Insertional; Ribonuclease H; Serine; Tyrosine | 1998 |
Direct effects of phosphorylation on the preferred backbone conformation of peptides: a nuclear magnetic resonance study.
Topics: Amino Acid Sequence; Biophysical Phenomena; Biophysics; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Oligopeptides; Phosphorylation; Protein Conformation; Serine; Threonine; Tyrosine | 1999 |
Contribution to Tl+, K+, and Na+ binding of Asn776, Ser775, Thr774, Thr772, and Tyr771 in cytoplasmic part of fifth transmembrane segment in alpha-subunit of renal Na,K-ATPase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Binding Sites; Cytoplasm; Hydroxides; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Potassium; Protein Structure, Tertiary; Recombinant Proteins; Serine; Sodium; Sodium-Potassium-Exchanging ATPase; Swine; Thallium; Threonine; Tyrosine | 1998 |
CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enzyme Activation; Female; Gene Expression; Hippocampus; In Situ Hybridization; Long-Term Potentiation; Methylazoxymethanol Acetate; Nerve Degeneration; Neurons; Organ Culture Techniques; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine; Synapses; Threonine; Tyrosine | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Adhesion Molecules; DNA Fragmentation; Down-Regulation; Flow Cytometry; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glioblastoma; Humans; Hydrogen Peroxide; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Serine; Tumor Cells, Cultured; Tyrosine; Wortmannin | 1999 |
Site-directed mutagenesis of phosphate-contacting amino acids of bovine pancreatic deoxyribonuclease I.
Topics: Amino Acids; Animals; Arginine; Asparagine; Cattle; Deoxyribonuclease I; DNA; Hydrolysis; Mutagenesis, Site-Directed; RNA, Transfer, Tyr; Serine; Substrate Specificity; Sugar Phosphates; Threonine; Thymidine; Tyrosine | 1999 |
The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.
Topics: Adjuvants, Immunologic; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; CD8 Antigens; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Humans; Imidazoles; Interleukin-12; Interleukin-2; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Serine; STAT1 Transcription Factor; STAT3 Transcription Factor; T-Lymphocyte Subsets; Trans-Activators; Tyrosine | 1999 |
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Topics: Animals; Cell Membrane; COS Cells; Epidermal Growth Factor; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus. Mutations in brief no. 130. Online.
Topics: Alleles; Amino Acid Substitution; Diabetes Mellitus, Type 2; Humans; Insulin Receptor Substrate Proteins; Phosphoproteins; Receptor, Insulin; Serine; Tyrosine | 1998 |
Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3beta and Shaggy.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Drosophila; Drosophila Proteins; Eukaryotic Initiation Factor-2B; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Guanine Nucleotide Exchange Factors; Molecular Sequence Data; Peptides; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Serine; Substrate Specificity; Threonine; Tyrosine | 1999 |
Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk.
Topics: Animals; Biological Transport; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Mice; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Serine; STAT2 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1999 |
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.
Topics: 3T3 Cells; Animals; Antiviral Agents; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Focal Adhesion Kinase 2; Immunity, Innate; Interferon-alpha; Interferon-gamma; Janus Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mutation; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine; Viruses | 1999 |
Transmodulation of epidermal growth factor receptor function by cyclic AMP-dependent protein kinase.
Topics: Animals; Catalytic Domain; Cattle; Cell Line; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Humans; Phosphorylation; Protein-Tyrosine Kinases; Serine; Tyrosine | 1999 |
Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; DNA-Binding Proteins; ets-Domain Protein Elk-1; Fibroblast Growth Factor 2; Humans; Kinetics; MAP Kinase Kinase 1; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Peptides, Cyclic; Pertussis Toxin; Phosphorylation; Potassium Channels; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Somatostatin; Serine; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine; Virulence Factors, Bordetella | 1999 |
Activation of STAT1 alpha by phosphatase inhibitor vanadate in glomerular mesangial cells: involvement of tyrosine and serine phosphorylation.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Glomerular Mesangium; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrosine; Vanadates | 1999 |
Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase.
Topics: Alcohol Oxidoreductases; Animals; Binding Sites; Biopterins; Cloning, Molecular; DNA, Complementary; Escherichia coli; Humans; Mutagenesis, Site-Directed; Mutation; Rats; Serine; Tyrosine | 1999 |
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Enzyme Activation; Humans; Jurkat Cells; Nuclear Proteins; Oncogene Protein v-cbl; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proteins; Retroviridae Proteins, Oncogenic; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1999 |
Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinase-dependent pathway.
Topics: Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colon; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Keratins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Serine; Signal Transduction; Solubility; Tyrosine; Vanadates | 1999 |
The linker domain of Stat1 is required for gamma interferon-driven transcription.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Transport; Cell Cycle Proteins; Cell Line; Cell Nucleus; CREB-Binding Protein; DNA; DNA-Binding Proteins; Drosophila; Fungal Proteins; Humans; Interferon-gamma; Molecular Sequence Data; Mutagenesis; Nuclear Proteins; Phosphorylation; Point Mutation; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid; Serine; STAT1 Transcription Factor; Time Factors; Trans-Activators; Transcription, Genetic; Tyrosine | 1999 |
Identification of amino acids that modulate mannose phosphorylation of mouse DNase I, a secretory glycoprotein.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cattle; COS Cells; Deoxyribonuclease I; Lysine; Mannose; Mice; Models, Molecular; Molecular Sequence Data; Phosphorylation; Point Mutation; Recombinant Fusion Proteins; Sequence Alignment; Serine; Tyrosine | 1999 |
Expression, purification, and characterization of the cytoplasmic domain of the human IGF-1 receptor using a baculovirus expression system.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; Baculoviridae; Cell Line; Cytosol; Humans; Kinetics; Magnesium; Manganese; Peptide Fragments; Phosphorylation; Polylysine; Receptor, IGF Type 1; Recombinant Proteins; Serine; Solubility; Spodoptera; Time Factors; Tyrosine | 1999 |
Site-directed mutagenesis and molecular modeling identify a crucial amino acid in specifying the heparin affinity of FGF-1.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Cysteic Acid; Cysteine; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Heparin; Humans; Iodine Radioisotopes; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Tyrosine | 1999 |
Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Complement C5a; Cytokines; DNA-Binding Proteins; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Neutrophils; Phosphorylation; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Tyrosine | 1999 |
Tyrosine phosphorylation of A17 during vaccinia virus infection: involvement of the H1 phosphatase and the F10 kinase.
Topics: Animals; Binding Sites; Cell Line; Chlorocebus aethiops; Dual Specificity Phosphatase 3; Escherichia coli; Membrane Proteins; Peptides; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Serine; Threonine; Tyrosine; Vaccinia virus; Viral Envelope Proteins; Viral Proteins | 1999 |
Tumor necrosis factor-alpha signals to the IFN-gamma receptor complex to increase Stat1alpha activation.
Topics: DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Humans; Interferon gamma Receptor; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Janus Kinase 2; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Interferon; Serine; Signal Transduction; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes.
Topics: Animals; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Ethanol; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Liver; Nuclear Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Signal Transduction; STAT3 Transcription Factor; Time Factors; Trans-Activators; TYK2 Kinase; Tyrosine | 1999 |
Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.
Topics: Animals; Antibodies, Monoclonal; Biological Transport; Cell Nucleus; Cells, Cultured; CREB-Binding Protein; DNA-Binding Proteins; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Macrophages; Mycobacterium tuberculosis; Nuclear Proteins; Phosphorylation; Receptors, IgG; RNA, Messenger; Serine; Signal Transduction; STAT1 Transcription Factor; Subcellular Fractions; Toxoplasma; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta; Tyrosine | 1999 |
Differential modulation of agonist potency and receptor coupling by mutations of Ser388Tyr and Thr389Pro at the junction of transmembrane domain VI and the third extracellular loop of human M(1) muscarinic acetylcholine receptors.
Topics: Amino Acid Sequence; Binding, Competitive; Cell Line; Humans; Membrane Proteins; Molecular Sequence Data; Muscarinic Agonists; Mutation; Proline; Protein Conformation; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Serine; Threonine; Tyrosine | 1999 |
Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2. A study with peptide substrates derived from immunophilin Fpr3.
Topics: Amino Acid Sequence; Casein Kinase II; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Peptide Fragments; Peptidylprolyl Isomerase; Phosphopeptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Serine; Substrate Specificity; Threonine; Tyrosine | 1999 |
Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19.
Topics: Acute-Phase Proteins; Antigens, CD19; DNA-Binding Proteins; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Antigen, B-Cell; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1999 |
The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.
Topics: Alleles; Cell Line; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Humans; Isoelectric Focusing; Phosphorylation; Protein Biosynthesis; Serine; Substrate Specificity; Threonine; Tyrosine | 1999 |
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice.
Topics: Animals; Biological Transport; Deoxyglucose; Glucose; Glucose Tolerance Test; Glycogen; Glycogen Synthase; Insulin; Insulin Receptor Substrate Proteins; Male; Mice; Mice, Knockout; Muscle Contraction; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Physical Conditioning, Animal; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Signal Transduction; Time Factors; Tyrosine | 1999 |
Characterization of insulin-like growth factor-1-induced activation of the JAK/STAT pathway in rat cardiomyocytes.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Insulin-Like Growth Factor I; Janus Kinase 1; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 1999 |
Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cell Line; Cnidarian Venoms; Female; Humans; Kidney; Kv1.1 Potassium Channel; Kv1.2 Potassium Channel; Kv1.3 Potassium Channel; Lysine; Models, Molecular; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Conformation; Recombinant Proteins; Sea Anemones; Serine; Transfection; Tyrosine; Xenopus laevis | 1999 |
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Consensus Sequence; Eukaryotic Cells; Glycosylation; Models, Molecular; Neural Networks, Computer; Nuclear Proteins; Phosphoproteins; Phosphorylation; Phylogeny; Protein Structure, Tertiary; Reproducibility of Results; Sensitivity and Specificity; Serine; Substrate Specificity; Threonine; Trans-Activators; Tyrosine | 1999 |
Modulation of human neutrophil responses to CD32 cross-linking by serine/threonine phosphatase inhibitors: cross-talk between serine/threonine and tyrosine phosphorylation.
Topics: Adult; Calcium; Calcium Signaling; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Neutrophil Activation; Neutrophils; Oncogene Protein v-cbl; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Receptors, IgG; Retroviridae Proteins, Oncogenic; Serine; Superoxides; Threonine; Tyrosine | 2000 |
New transthyretin variants SER 91 and SER 116 associated with familial amyloidotic polyneuropathy. Mutations in brief no. 151. Online.
Topics: Aged; Alanine; Amyloid Neuropathies; Humans; Male; Mutation; Prealbumin; Protein Isoforms; Serine; Tyrosine | 1998 |
Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Differentiation; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Dominant; Humans; Interferon-gamma; Interleukin-6; Mutagenesis, Site-Directed; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Proteins; Proto-Oncogene Proteins p21(ras); Rats; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT1 Transcription Factor; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine | 2000 |
Inhibition of I kappaB-alpha phosphorylation at serine and tyrosine acts independently on sensitization to DNA damaging agents in human glioma cells.
Topics: Antineoplastic Agents; Benzoquinones; Cell Cycle; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Radiation; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Glioma; Humans; I-kappa B Kinase; Lactams, Macrocyclic; Ligases; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Quinones; Radiation Tolerance; Rifabutin; Sequence Deletion; Serine; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Ultraviolet Rays | 2000 |
Random-coil chemical shifts of phosphorylated amino acids.
Topics: Amino Acids; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphorus Isotopes; Phosphorylation; Protein Structure, Secondary; Serine; Threonine; Tyrosine | 1999 |
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
Topics: Blotting, Western; Carrier Proteins; Catalysis; Cell Line; Cysteine; DNA, Complementary; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Models, Chemical; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Serine; SH2 Domain-Containing Protein Tyrosine Phosphatases; src Homology Domains; Tyrosine | 2000 |
Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Leptin; Liver; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Receptors, Cell Surface; Receptors, Leptin; Serine; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2000 |
Conformation of the RNA polymerase II C-terminal domain: circular dichroism of long and short fragments.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Aminoisobutyric Acids; Animals; Binding Sites; Circular Dichroism; Conserved Sequence; Hydrogen Bonding; Mice; Molecular Weight; Peptide Fragments; Phosphorylation; Proline; Protein Structure, Secondary; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; RNA Polymerase II; Serine; Solvents; Temperature; Trifluoroethanol; Tyrosine; Water | 2000 |
Mutation of serine 395 of tyrosine hydroxylase decouples oxygen-oxygen bond cleavage and tyrosine hydroxylation.
Topics: Animals; Hydroxylation; Kinetics; Oxygen; Point Mutation; Rats; Serine; Structure-Activity Relationship; Substrate Specificity; Tyrosine; Tyrosine 3-Monooxygenase | 2000 |
Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein tip.
Topics: Binding Sites; Cell Line; Herpesvirus 2, Saimiriine; Humans; Nucleocytoplasmic Transport Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins c-fos; RNA-Binding Proteins; Serine; Transcription Factors; Tyrosine | 2000 |
The catalytic Tyr-9 of glutathione S-transferase A1-1 controls the dynamics of the C terminus.
Topics: 4-Chloro-7-nitrobenzofurazan; Amino Acid Substitution; Animals; Binding Sites; Calorimetry; Catalytic Domain; Glutathione; Glutathione Transferase; Humans; Hydrogen Bonding; Isoenzymes; Kinetics; Models, Molecular; Phenylalanine; Protein Conformation; Rats; Serine; Thermodynamics; Tyrosine | 2000 |
Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress.
Topics: Animals; Calpain; Casein Kinase II; Cysteine Endopeptidases; DNA; DNA-Binding Proteins; Enzyme Activation; Humans; Hydrogen Peroxide; I-kappa B Kinase; I-kappa B Proteins; Mice; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Peptide Fragments; Phosphorylation; Point Mutation; Proteasome Endopeptidase Complex; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Protein Tyrosine Phosphatases; Serine; Tumor Cells, Cultured; Tyrosine | 2000 |
Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol.
Topics: Cell Line; DNA-Binding Proteins; Humans; Interferon-alpha; Janus Kinase 1; Jurkat Cells; Membrane Proteins; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation Inhibitors; Protein-Tyrosine Kinases; Receptor, Interferon alpha-beta; Receptors, Interferon; Ribonucleases; Serine; Signal Transduction; STAT1 Transcription Factor; STAT2 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Stilbenes; Time Factors; Trans-Activators; Tyrosine | 2000 |
Arginine kinase from Nautilus pompilius, a living fossil. Site-directed mutagenesis studies on the role of amino acid residues in the Guanidino specificity region.
Topics: Amino Acid Sequence; Animals; Arginine Kinase; Base Sequence; Catalytic Domain; Decapodiformes; Evolution, Molecular; Glycine; Horseshoe Crabs; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mollusca; Mutagenesis, Site-Directed; Octopodiformes; Phylogeny; Sequence Homology, Amino Acid; Serine; Tyrosine; Valine | 2000 |
Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells.
Topics: Animals; Calpain; Caveolin 1; Caveolins; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Endothelium, Vascular; HSP90 Heat-Shock Proteins; Hypoxia; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Serine; Swine; Tyrosine | 2000 |
A single substitution of the insulin receptor kinase inhibits serine autophosphorylation in vitro: evidence for an interaction between the C-terminus and the activation loop.
Topics: Humans; Insulin Receptor Substrate Proteins; Kinetics; Mutation; Peptide Fragments; Peptide Mapping; Phosphates; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Insulin; Recombinant Proteins; Serine; Substrate Specificity; Tyrosine | 2000 |
Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Enzyme Activation; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptor, Insulin; Serine; Signal Transduction; src Homology Domains; Substrate Specificity; Tyrosine | 2000 |
Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit.
Topics: Adenoviridae; Amino Acid Substitution; Arginine; Aspartic Acid; beta-Galactosidase; Blotting, Western; Cells, Cultured; DNA Primers; Gene Expression; Glucose; Glycogen; Glycogen Synthase; Humans; Insulin; Muscle, Skeletal; Mutagenesis, Site-Directed; Mutation, Missense; Phosphoprotein Phosphatases; Protein Phosphatase 1; Serine; Transfection; Tyrosine | 2000 |
Towards models of vanadate-dependent haloperoxidases: the hydroxyl side chain.
Topics: Binding Sites; Cysteine; Homoserine; Hydroxyl Radical; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Structure; Peroxidases; Protein Tyrosine Phosphatases; Serine; Threonine; Tyrosine; Vanadates | 2000 |
Functional comparison of the NAD binding cleft of ADP-ribosylating toxins.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cholera Toxin; Diphtheria Toxin; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Phenylalanine; Poly(ADP-ribose) Polymerases; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Tyrosine | 2000 |
STAT3 regulates the growth and immunoglobulin production of BCL(1) B cell lymphoma through control of cell cycle progression.
Topics: Animals; B-Lymphocytes; Cell Cycle; Cell Division; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Gene Expression; Humans; Immunoglobulin M; Lymphoma, B-Cell; Male; Mice; Mice, Inbred BALB C; Peritoneum; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Rabbits; Serine; Spleen; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2000 |
The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antigens, CD; Carrier Proteins; CD79 Antigens; Cytoplasm; Enzyme Inhibitors; Humans; Immunoglobulin Fragments; Immunoglobulin Variable Region; Molecular Sequence Data; Phosphoproteins; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; Serine; Signal Transduction; Threonine; Tumor Cells, Cultured; Tyrosine; Vanadates | 2000 |
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.
Topics: Androstadienes; Blotting, Southern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Dimerization; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Esophageal Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Ligands; Morpholines; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Receptor, ErbB-2; Receptor, ErbB-3; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Wortmannin | 2000 |
Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 Enzyme System; DNA Primers; DNA-Binding Proteins; Female; Gene Expression Regulation, Enzymologic; Growth Hormone; Hepatocyte Nuclear Factor 3-alpha; Hepatocyte Nuclear Factor 3-gamma; Hepatocyte Nuclear Factor 6; Homeodomain Proteins; Humans; Liver; Male; Milk Proteins; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Rats; Serine; STAT5 Transcription Factor; Steroid Hydroxylases; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2000 |
Antigen receptor signal transduction: activating and inhibitory antigen receptors regulate STAT1 serine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; DNA; DNA-Binding Proteins; Humans; Jurkat Cells; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, IgG; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2000 |
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
Topics: Alanine; Apoptosis; Binding Sites; Caspase 1; Caspase 3; Caspase 6; Caspase 7; Caspase 8; Caspase 9; Caspases; Catalysis; Escherichia coli; Fluorescent Dyes; Glycine; Humans; Kinetics; Models, Molecular; ortho-Aminobenzoates; Peptides; Protein Binding; Proteins; Recombinant Proteins; Serine; Substrate Specificity; Tyrosine | 2000 |
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Humans; Interleukin-12; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; MAP Kinase Kinase 4; MAP Kinase Kinase 6; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Recombinant Fusion Proteins; Serine; Signal Transduction; STAT4 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine | 2000 |
The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation.
Topics: Amino Acid Motifs; Amino Acid Substitution; Binding Sites; Cells, Cultured; Chorionic Gonadotropin; Conserved Sequence; Cyclic AMP; Gene Deletion; Humans; Iodine Radioisotopes; Leucine-Rich Repeat Proteins; Models, Molecular; Photoaffinity Labels; Protein Conformation; Proteins; Receptors, LH; Serine; Tyrosine | 2001 |
The enamel protein amelogenin binds to the N-acetyl-D-glucosamine-mimicking peptide motif of cytokeratins.
Topics: Acetylglucosamine; Amelogenin; Amino Acid Motifs; Animals; Binding Sites; Binding, Competitive; Dental Enamel Proteins; Dose-Response Relationship, Drug; Genetic Linkage; Hemagglutinins; Humans; Keratins; Kinetics; Mice; Models, Chemical; Peptides; Phenylalanine; Proline; Protein Binding; Serine; Time Factors; Tyrosine; X Chromosome | 2000 |
Melatonin-induced organelle movement in melanophores is coupled to tyrosine phosphorylation of a high molecular weight protein.
Topics: Adenylate Cyclase Toxin; Animals; Blotting, Western; Cell Aggregation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Genistein; GTP-Binding Proteins; Kinetics; Melanophores; Melatonin; Pertussis Toxin; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serine; Signal Transduction; Threonine; Time Factors; Tyrosine; Virulence Factors, Bordetella; Xenopus | 2000 |
Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Binding Sites; CHO Cells; Cricetinae; DNA-Binding Proteins; Enzyme Activation; Growth Hormone; Kinetics; Macromolecular Substances; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mutagenesis, Site-Directed; Phosphorylation; Proteins; Rabbits; Receptors, Somatotropin; Recombinant Proteins; Sequence Deletion; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase.
Topics: Alanine; Amino Acid Substitution; Animals; Apoenzymes; Binding Sites; Calorimetry, Differential Scanning; Catalysis; Cytosol; Formaldehyde; Glutamic Acid; Glycine Hydroxymethyltransferase; Humans; Kinetics; Liver; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Rabbits; Recombinant Fusion Proteins; Serine; Sheep; Structure-Activity Relationship; Tetrahydrofolates; Tyrosine | 2000 |
Five novel genetic variants in the promoter and coding region of the alpha B-crystallin gene (CRYAB): -652G>A, -650C>G, -249G>C, S41Y, P51L.
Topics: Amino Acid Substitution; Crystallins; Exons; Genetic Variation; Humans; Leucine; Mutation, Missense; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Serine; Tyrosine | 2000 |
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, Phytogenic; Carcinoma; Cyanogen Bromide; Cycloheximide; Drug Interactions; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Microtubules; Paclitaxel; Peptide Fragments; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-raf; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine | 2000 |
DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinase II; Cations; Chromatography, Agarose; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Genistein; Guanosine Triphosphate; Humans; Magnesium; Manganese; Medulloblastoma; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phosphates; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Threonine; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Amino Acid Substitution; Case-Control Studies; Electrophoresis, Agar Gel; Female; Genotype; Humans; Male; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Polymorphism, Genetic; Serine; Thiolester Hydrolases; Tyrosine; Ubiquitin Thiolesterase | 2000 |
Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA-Binding Proteins; Enzyme Inhibitors; Growth Inhibitors; Human T-lymphotropic virus 1; Humans; Immunosuppressive Agents; Interleukin-15; Interleukin-2; Janus Kinase 3; Lymphocyte Activation; Milk Proteins; NF-kappa B; Nuclear Proteins; Phosphorylation; Phytohemagglutinins; Protein-Tyrosine Kinases; Serine; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrosine; Tyrphostins | 2000 |
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
Topics: Animals; Cell Line; Cloning, Molecular; Enzyme Activation; Humans; Insecta; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase 7; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osmosis; Peptide Mapping; Phosphorylation; Protein Isoforms; Serine; Substrate Specificity; Threonine; Trypsin; Tyrosine | 2000 |
Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Enzyme Activation; HL-60 Cells; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Lipoxins; Mutagenesis, Site-Directed; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Phosphorylation; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Lipoxin; Serine; Signal Transduction; Transfection; Tyrosine | 2000 |
HLA-B polymorphism affects interactions with multiple endoplasmic reticulum proteins.
Topics: Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antiporters; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Calcium-Binding Proteins; Calreticulin; Cysteine Endopeptidases; Endoplasmic Reticulum; HLA-B7 Antigen; Humans; Immunoglobulin G; Immunoglobulins; Leupeptins; Membrane Transport Proteins; Multienzyme Complexes; Mutagenesis, Site-Directed; Polymorphism, Genetic; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Binding; Rabbits; Ribonucleoproteins; Serine; Tyrosine | 2000 |
Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells.
Topics: Amides; Amino Acid Sequence; Animals; Chlorates; Cholecystokinin; Chromatography, Gel; Culture Media; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Protein Precursors; Protein Processing, Post-Translational; Rats; Serine; Sulfates; Transfection; Tumor Cells, Cultured; Tyrosine | 2000 |
The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa.
Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Blotting, Northern; Chromatography, Thin Layer; Cloning, Molecular; Cnidaria; COS Cells; Cyclooxygenase 1; Cyclooxygenase 2; DNA, Complementary; HeLa Cells; Histidine; Humans; Isoenzymes; Isoleucine; Membrane Proteins; Microscopy, Fluorescence; Models, Genetic; Molecular Sequence Data; Phylogeny; Plasmids; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Binding; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine; Tyrosine | 2001 |
Autocrine motility factor (neuroleukin, phosphohexose isomerase) induces cell movement through 12-lipoxygenase-dependent tyrosine phosphorylation and serine dephosphorylation events.
Topics: Actins; Animals; Cell Movement; Enzyme Inhibitors; Glucose-6-Phosphate Isomerase; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Melanoma; Mice; Microscopy, Confocal; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proteins; Serine; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 1999 |
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.
Topics: Alanine; Benzimidazoles; Binding Sites; Carbolines; Carboxylic Acids; Dipeptides; Isoquinolines; Kinetics; Ligands; Peptides; Proline; Propionates; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, mu; Serine; Tetrahydroisoquinolines; Tyrosine | 2000 |
Tubulin is hyperphosphorylated on serine and tyrosine residues in arsenite-resistant Leishmania donovani promastigotes.
Topics: Animals; Arsenites; Culture Media; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Leishmania donovani; Phosphorylation; Serine; Tubulin; Tyrosine | 2000 |
Serotonin transporter phosphorylation modulated by tetanus toxin.
Topics: Animals; Biological Transport; Brain; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Isotope Labeling; Maleimides; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; Serine; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes; Tetanus Toxin; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases; Tyrosine | 2000 |
The vaccinia virus A33R protein provides a chaperone function for viral membrane localization and tyrosine phosphorylation of the A36R protein.
Topics: Actins; HeLa Cells; Humans; Molecular Chaperones; Phosphorylation; Serine; Tyrosine; Vaccinia virus; Viral Envelope Proteins; Viral Structural Proteins | 2001 |
Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adipocytes; Animals; beta-Cyclodextrins; Carcinogens; Caveolae; Cell Differentiation; Cell Division; Cell Membrane; Cells, Cultured; Cholesterol; Cyclodextrins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucose; Immunoblotting; Immunohistochemistry; Insulin; Insulin Receptor Substrate Proteins; MAP Kinase Signaling System; Mice; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Threonine; Time Factors; Tyrosine | 2001 |
Posttranslational modifications of recombinant myotube-synthesized human factor IX.
Topics: 1-Carboxyglutamic Acid; Adenoviridae; Carbohydrates; Cell Culture Techniques; Culture Media, Conditioned; Factor IX; Genetic Vectors; Humans; Molecular Sequence Data; Muscle Fibers, Skeletal; Partial Thromboplastin Time; Phosphorylation; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Analysis, Protein; Serine; Sulfates; Transduction, Genetic; Tyrosine | 2001 |
Kinase suppressor of Ras signals through Thr269 of c-Raf-1.
Topics: Animals; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Humans; Mice; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Proteins; Serine; Signal Transduction; Threonine; Transfection; Tyrosine; Valine | 2001 |
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway.
Topics: CREB-Binding Protein; Drug Synergism; Enzyme Activation; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nuclear Proteins; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivators; Oncogene Protein pp60(v-src); Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptors, Estrogen; Response Elements; Serine; Signal Transduction; Structure-Activity Relationship; Tamoxifen; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tyrosine; Vitellogenins | 2001 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
Topics: Animals; Anisomycin; CHO Cells; Cricetinae; Insulin; Insulin Antagonists; Insulin Resistance; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Insulin; Serine; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Line; Humans; Immunophilins; Insulin Receptor Substrate Proteins; Interferon-alpha; Janus Kinase 1; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Rats; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine | 2001 |
IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Female; Interleukin-4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Serine; STAT6 Transcription Factor; Trans-Activators; Tyrosine | 2000 |
Tyrosine phosphorylation of p120(ctn) in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity.
Topics: Amino Acid Substitution; Animals; Base Sequence; Cadherins; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Delta Catenin; DNA Primers; Mice; Oncogene Protein pp60(v-src); Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Serine; Threonine; Tyrosine | 2001 |
Calcium-induced alterations in the functioning of protein serine/threonine and tyrosine kinases in Streptomyces fradiae cells.
Topics: Calcium; Cell Division; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Ions; Phosphorylation; Protein Denaturation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Streptomyces; Threonine; Time Factors; Tyrosine | 2000 |
Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cell Division; Cell Line; Cell Movement; Cell Nucleus; Cells, Cultured; DNA; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Graft Enhancement, Immunologic; Graft Survival; Heart Transplantation; Humans; Immunosuppressive Agents; Injections, Intraperitoneal; Interleukin-2; Janus Kinase 3; Leukocytes, Mononuclear; Milk Proteins; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Receptors, Interleukin-2; Serine; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators; Tumor Suppressor Proteins; Tyrosine; Tyrphostins | 2001 |
Helix packing in the lactose permease of Escherichia coli: distances between site-directed nitroxides and a lanthanide.
Topics: Binding Sites; Chelating Agents; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Escherichia coli Proteins; Gadolinium; Heterocyclic Compounds; Isoleucine; Membrane Transport Proteins; Mesylates; Metals, Rare Earth; Monoiodotyrosine; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Nitrobenzenes; Protein Structure, Secondary; Serine; Spin Labels; Symporters; Tyrosine | 2001 |
Modifying the temporal profile of the high-potency sweetener neotame.
Topics: Cinnamates; Dipeptides; Drug Stability; Models, Molecular; Molecular Conformation; Monte Carlo Method; Serine; Sweetening Agents; Taste; Tyrosine | 2001 |
Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.
Topics: Animals; Animals, Newborn; bcl-X Protein; Cell Survival; Cysteine Endopeptidases; DNA-Binding Proteins; Gene Expression Regulation; Hippocampus; I-kappa B Proteins; Multienzyme Complexes; Nerve Growth Factor; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; RNA, Messenger; Serine; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle.
Topics: Acetophenones; Animals; Benzopyrans; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Insulin; Insulin-Like Growth Factor I; Isoenzymes; Muscle, Skeletal; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Tyrosine | 2001 |
The H-phosphonate approach to the synthesis of phosphopeptides on solid phase.
Topics: Chromatography, High Pressure Liquid; Organophosphonates; Phosphopeptides; Phosphorylation; Serine; Tyrosine | 2001 |
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
Topics: Adenoviridae; Androstadienes; Animals; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Threonine; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Wortmannin | 2001 |
A motif-based profile scanning approach for genome-wide prediction of signaling pathways.
Topics: Algorithms; Amino Acid Motifs; Amino Acid Sequence; Animals; Cattle; Databases, Factual; Genome; Humans; Internet; Mice; Molecular Sequence Data; Rats; Serine; Signal Transduction; Software; Threonine; Tyrosine | 2001 |
A systematic approach to the analysis of protein phosphorylation.
Topics: Amino Acid Sequence; Biochemistry; Caseins; Databases, Factual; Fungal Proteins; Gas Chromatography-Mass Spectrometry; Glucose; Glutathione Transferase; Mass Spectrometry; Models, Chemical; Molecular Sequence Data; Peptides; Phosphorylation; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Serine; Threonine; Time Factors; Tyrosine | 2001 |
Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.
Topics: Amino Acid Substitution; Binding Sites; Catalysis; Crystallography, X-Ray; Escherichia coli; Freezing; Glutamic Acid; Isocitrate Dehydrogenase; Macromolecular Substances; Magnesium; Malates; NADP; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 2001 |
Role of the flexible loop of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus in enzyme catalysis.
Topics: Amino Acid Sequence; Animals; Binding Sites; Catalysis; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Protein Structure, Secondary; Serine; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics; Tritrichomonas foetus; Tryptophan; Tyrosine | 2001 |
Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cells, Cultured; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Imidazoles; In Situ Nick-End Labeling; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine | 2001 |
An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Bacterial Proteins; Base Sequence; Carrier Proteins; Conserved Sequence; Escherichia coli; Escherichia coli Proteins; Genes, Dominant; Genetic Complementation Test; Humans; Membrane Transport Proteins; Molecular Sequence Data; Mutation; Phenotype; Protein Structure, Tertiary; Protein Subunits; Protein Transport; SEC Translocation Channels; SecA Proteins; Serine; Tyrosine | 2001 |
BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model.
Topics: Animals; Fusion Proteins, bcr-abl; Gene Expression Regulation; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred NOD; Mice, SCID; Oncogene Proteins; Oncogenes; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr; RNA, Messenger; Serine; Tyrosine | 2001 |
Tyrosine kinase-mediated serine phosphorylation of adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Blotting, Western; Catalytic Domain; Cells, Cultured; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Humans; Intracellular Fluid; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoamino Acids; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Rats; Serine; Staurosporine; Tyrosine; Up-Regulation; Vanadates | 2001 |
Nongenomic estrogen action in human lung myofibroblasts.
Topics: Binding Sites; Cell Division; Cells, Cultured; Cytoplasm; Estradiol; Estrogen Receptor alpha; Fibroblasts; Humans; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Phosphorylation; Proto-Oncogene Proteins c-raf; Receptors, Estrogen; Serine; Tyrosine | 2001 |
Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases.
Topics: Animals; Calcium; Carbachol; Carcinogens; Cholinergic Agents; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Estrenes; Isoenzymes; Male; Neurons; Parotid Gland; PC12 Cells; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serine; src-Family Kinases; Substance P; Tetradecanoylphorbol Acetate; Threonine; Tyrosine; Vanadates | 2001 |
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.
Topics: Animals; Cell Line; DNA-Binding Proteins; eIF-2 Kinase; Enzyme Activation; Gene Expression; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-fos; Receptors, Platelet-Derived Growth Factor; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2001 |
The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism.
Topics: Amino Acid Sequence; Arabidopsis; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Dimerization; Glutathione; Glutathione Transferase; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Sequence Alignment; Serine; Tyrosine | 2001 |
Acid-base catalysis by UDP-galactose 4-epimerase: correlations of kinetically measured acid dissociation constants with thermodynamic values for tyrosine 149.
Topics: Alanine; Catalysis; Deuterium; Electron Transport; Enzyme Activation; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Phenylalanine; Protein Conformation; Protons; Serine; Spectrometry, Fluorescence; Temperature; Thermodynamics; Tyrosine; UDPglucose 4-Epimerase | 2001 |
TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesis.
Topics: Animals; Bone Marrow Cells; Bone Resorption; Cells, Cultured; Cytosol; Dentin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Deletion; Gene Products, tat; I-kappa B Proteins; Immunoblotting; Macrophages; Mice; Mutation; NF-KappaB Inhibitor alpha; Osteoclasts; Phosphorylation; Protein Binding; Recombinant Fusion Proteins; Serine; Time Factors; Tyrosine | 2001 |
Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation, Enzymologic; Genes, Dominant; Genes, Reporter; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; STAT1 Transcription Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cytosol; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Glucose; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tyrosine | 2001 |
Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site.
Topics: Amino Acid Sequence; Asparagine; Base Sequence; Binding Sites; Catalytic Domain; DNA; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Magnesium Chloride; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid; Serine; Sodium Chloride; Time Factors; Tyrosine; Vaccinia virus | 2001 |
Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-Cl-flavin.
Topics: 4-Hydroxybenzoate-3-Monooxygenase; Alanine; Amino Acid Substitution; Anaerobiosis; Asparagine; Aspartic Acid; Catalysis; Flavin-Adenine Dinucleotide; Hydroxylation; Lysine; Methionine; Mutagenesis, Site-Directed; Oxidation-Reduction; Parabens; Phenylalanine; Riboflavin; Serine; Spectrophotometry; Substrate Specificity; Tyrosine | 2001 |
Copper specifically regulates intracellular phosphorylation of the Wilson's disease protein, a human copper-transporting ATPase.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Blotting, Western; Carrier Proteins; Cation Transport Proteins; Cells, Cultured; Copper; Copper-Transporting ATPases; COS Cells; Humans; Immunohistochemistry; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Serine; Tumor Cells, Cultured; Tyrosine | 2001 |
Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene.
Topics: Base Sequence; Carcinogens; Cells, Cultured; DNA; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon gamma Receptor; Interferon-gamma; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Receptors, Interferon; Serine; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2001 |
Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences.
Topics: Acyltransferases; Alanine; Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Esterification; Gene Deletion; Gene Expression; Humans; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sterol O-Acyltransferase; Structure-Activity Relationship; Transfection; Tryptophan; Tyrosine | 2001 |
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta.
Topics: Apoptosis Inducing Factor; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Cyclin D1; Enzyme Inhibitors; Flavoproteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hot Temperature; Humans; Lithium; Membrane Proteins; Phosphorylation; Serine; Staurosporine; Tumor Cells, Cultured; Tyrosine | 2001 |
v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication.
Topics: Cell Communication; Cell Membrane; Clone Cells; Connexin 43; Gap Junctions; Mitogen-Activated Protein Kinases; Models, Biological; Mutagenesis, Site-Directed; Oncogene Protein pp60(v-src); Phosphorylation; Serine; Tyrosine | 2001 |
MEN2A-RET-induced cellular transformation by activation of STAT3.
Topics: 3T3 Cells; Animals; Binding Sites; Cell Division; Cell Line; Cell Transformation, Neoplastic; COS Cells; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drosophila Proteins; Enzyme Activation; Genes, Reporter; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Oncogenes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Serine; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine; Up-Regulation | 2001 |
Solid-phase glycosylation of peptide templates and on-bead MAS-NMR analysis: perspectives for glycopeptide libraries.
Topics: Amino Acid Sequence; Carbohydrate Conformation; Glycopeptides; Glycosylation; Indicators and Reagents; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Conformation; Serine; Threonine; Tyrosine | 2001 |
Effects of flavin-binding motif amino acid mutations in the NADH-cytochrome b5 reductase catalytic domain on protein stability and catalysis.
Topics: Amino Acid Motifs; Animals; Arginine; Binding Sites; Catalysis; Catalytic Domain; Circular Dichroism; Cytochrome Reductases; Cytochrome-B(5) Reductase; Enzyme Stability; Flavin-Adenine Dinucleotide; Kinetics; Models, Chemical; Mutation; NAD; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Serine; Swine; Tyrosine | 2001 |
Electrochemical evaluation of the interfacial capacitance upon phosphorylation of amino acid analogue molecular films.
Topics: Amino Acids; Electrochemistry; Phosphorylation; Serine; Spectrophotometry, Infrared; Threonine; Tyrosine | 2001 |
The roles of the N-terminal portions of various tachykinins in promoting salivation.
Topics: Analysis of Variance; Animals; Eledoisin; Injections, Intraperitoneal; Isoleucine; Kassinin; Male; Models, Animal; Neurokinin A; Neurokinin B; Phenylalanine; Rats; Rats, Sprague-Dawley; Salivation; Serine; Statistics as Topic; Submandibular Gland; Tachykinins; Tyrosine; Valine | 2001 |
Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Baculoviridae; Binding Sites; Blotting, Western; Carbon-Carbon Ligases; Catalysis; Catalytic Domain; Cell Line; Cysteine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Insecta; Ions; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides; Phenylalanine; Protein Binding; Protein Precursors; Protein Structure, Tertiary; Prothrombin; Rabbits; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Tyrosine; Vitamin K | 2001 |
Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; CHO Cells; Cricetinae; DNA-Binding Proteins; Female; Fibroblasts; Humans; Janus Kinase 2; Kidney; Liver; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Ovary; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Inbred BUF; rhoA GTP-Binding Protein; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine | 2001 |
Early steps of insulin action in the skin of intact rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; GRB2 Adaptor Protein; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Serine; Skin; Time Factors; Tyrosine | 2001 |
The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells.
Topics: Actin Cytoskeleton; Actinin; Actins; Amino Acid Sequence; Breast; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epithelial Cells; Female; Humans; Integrin beta1; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Serine; Threonine; Tumor Cells, Cultured; Tyrosine | 2001 |
Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.
Topics: Amino Acid Sequence; Animals; Aquaporin 4; Aquaporins; Casein Kinase II; Cell Line; Clathrin; DNA-Binding Proteins; Dogs; Endocytosis; Leucine; Lysosomes; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Sorting Signals; Protein Transport; Rats; Sequence Homology, Amino Acid; Serine; Transcription Factor AP-2; Transcription Factors; Tyrosine | 2001 |
The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles.
Topics: Cell Line; Cyclin-Dependent Kinases; Endopeptidases; Enzyme Inhibitors; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Genistein; HIV-1; Humans; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Purines; Serine; Threonine; Tyrosine; Virion | 2002 |
IL-10 promotes survival of microglia without activating Akt.
Topics: Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Coloring Agents; DNA-Binding Proteins; Enzyme Activation; Insulin-Like Growth Factor I; Interleukin-10; Mice; Microglia; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Interleukin; Receptors, Interleukin-10; Serine; STAT3 Transcription Factor; Tetrazolium Salts; Thiazoles; Trans-Activators; Tyrosine | 2002 |
Molecular characteristics of small intestinal and renal brush border thiamin transporters in rats.
Topics: Animals; Arginine; Carboxylic Acids; Cross-Linking Reagents; Histidine; In Vitro Techniques; Intestine, Small; Kidney; Lysine; Membrane Transport Proteins; Microvilli; Rats; Rats, Wistar; Serine; Sulfhydryl Compounds; Tyrosine | 2002 |
Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins.
Topics: Anisomycin; Cycloheximide; Genes, erbB; Genes, erbB-2; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoproteins; Serine; Threonine; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association.
Topics: Animals; Butadienes; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epithelial Cells; Escherichia coli; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glutathione Transferase; Hepatocyte Growth Factor; Kidney Tubules; MAP Kinase Signaling System; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nitriles; Paxillin; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Serine; Threonine; Time Factors; Tyrosine | 2002 |
Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases.
Topics: Agammaglobulinaemia Tyrosine Kinase; Blood Platelets; Blotting, Western; Calcium; Crotalid Venoms; Cytosol; Glutathione Transferase; Humans; Isoenzymes; Models, Biological; Myelin Basic Protein; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-theta; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Serine; Serotonin; Signal Transduction; Threonine; Time Factors; Tyrosine | 2002 |
Contraction regulation of Akt in rat skeletal muscle.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Morpholines; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Serine; Signal Transduction; Threonine; Time Factors; Tyrosine; Wortmannin | 2002 |
The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Catalysis; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Enzymologic; Kinetics; Mass Spectrometry; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Phosphorylation; Plasmids; Protein Structure, Tertiary; Rats; Serine; Time Factors; Tyrosine | 2002 |
A 45-kDa protein kinase related to mitogen-activated protein kinase is activated in tobacco cells treated with a phorbol ester.
Topics: Cells, Cultured; Cycloheximide; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Weight; Nicotiana; Phosphorylation; Plant Proteins; Serine; Stress, Mechanical; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2002 |
Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Erythropoietin; Humans; Janus Kinase 2; Luciferases; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Erythropoietin; Recombinant Proteins; Serine; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Stem Cells; Time Factors; Trans-Activators; Tumor Suppressor Proteins; Tyrosine | 2002 |
Probing substrate binding to metallo-beta-lactamase L1 from Stenotrophomonas maltophilia by using site-directed mutagenesis.
Topics: Asparagine; beta-Lactamases; Binding Sites; Carbapenems; Cephalosporins; Computational Biology; Isoleucine; Kinetics; Metals; Models, Molecular; Mutagenesis, Site-Directed; Penicillins; Phenylalanine; Protein Binding; Serine; Stenotrophomonas maltophilia; Tyrosine | 2002 |
Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase.
Topics: Cyclic AMP; Drosophila Proteins; Fluorescent Antibody Technique; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Mutagenesis, Site-Directed; Mutation; Nerve Growth Factors; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; rac GTP-Binding Proteins; Receptor Protein-Tyrosine Kinases; Serine; Tyrosine | 2002 |
Mutations of tyrosine 537 in the human estrogen receptor-alpha selectively alter the receptor's affinity for estradiol and the kinetics of the interaction.
Topics: Animals; Cell Line; Crystallography, X-Ray; DNA, Complementary; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Glutamic Acid; Humans; Hydrogen Bonding; Insecta; Kinetics; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Peptides; Phenylalanine; Protein Binding; Protein Conformation; Receptors, Estrogen; Serine; Time Factors; Transfection; Tyrosine | 2002 |
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.
Topics: 3T3 Cells; Animals; Catalysis; Enzyme Activation; Mice; Mitosis; Mutation; Nocodazole; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Serine; src Homology Domains; src-Family Kinases; Tyrosine | 2002 |
Positive contribution of hydration structure on the surface of human lysozyme to the conformational stability.
Topics: Arginine; Asparagine; Aspartic Acid; Crystallography, X-Ray; Humans; Models, Molecular; Muramidase; Mutation; Protein Binding; Protein Conformation; Serine; Thermodynamics; Tyrosine; Valine; Water | 2002 |
Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes.
Topics: Catalysis; Citrobacter freundii; Crystallization; Kinetics; Models, Chemical; Protein Binding; Proteus vulgaris; Serine; Spectrophotometry; Tryptophanase; Tyrosine; Tyrosine Phenol-Lyase; Ultraviolet Rays | 2002 |
The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status.
Topics: Amino Acid Sequence; Cell Line; Cyclic AMP-Dependent Protein Kinases; DNA; Dopamine beta-Hydroxylase; Electrophoresis, Gel, Two-Dimensional; Genes, Reporter; Homeodomain Proteins; Humans; Models, Biological; Molecular Sequence Data; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Serine; Signal Transduction; Threonine; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tyrosine | 2002 |
Study of the kinetics of oxidation of monophenols by tyrosinase. The effect of reducers.
Topics: Ascorbic Acid; Aspergillus flavus; Enzyme Activation; Iron; Kinetics; Monophenol Monooxygenase; Oxidation-Reduction; Oxygen; Phenols; Serine; Tyrosine | 2002 |
Selective inhibition of STAT3 phosphorylation by sodium salicylate in cardiac fibroblasts.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA; DNA-Binding Proteins; Fibroblasts; Heart; Phosphorylation; Rats; Reducing Agents; Serine; Signal Transduction; Sodium Salicylate; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2002 |
Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Blood Proteins; Casein Kinase II; Caspase 3; Caspases; Cell Death; Cell Survival; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Humans; Jurkat Cells; Phosphorylation; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Serine; Threonine; Time Factors; Triazoles; Tyrosine | 2002 |
Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms.
Topics: Amino Acids; Animals; Biological Transport; Glucose; Glycogen Synthase Kinase 3; Heart; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Metabolism; Mitogen-Activated Protein Kinases; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Threonine; Tyrosine | 2002 |
Comparison of the catalytic roles played by the KMSKS motif in the human and Bacillus stearothermophilus trosyl-tRNA synthetases.
Topics: Adenosine Triphosphate; Amino Acid Motifs; Catalysis; Dose-Response Relationship, Drug; Geobacillus stearothermophilus; Humans; Kinetics; Lysine; Models, Chemical; Mutagenesis, Site-Directed; Potassium; Potassium Chloride; RNA, Transfer; Serine; Tyrosine; Tyrosine-tRNA Ligase | 2002 |
The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry.
Topics: Amino Acid Sequence; Animals; Cell Line; Chemokine CXCL12; Chemokines, CXC; Chondroitin Sulfates; Dogs; HIV-1; Humans; Membrane Fusion; Molecular Sequence Data; Protein Processing, Post-Translational; Receptors, CXCR4; Sequence Homology, Amino Acid; Serine; Tyrosine | 2002 |
Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Binding Sites; Calcium; Cells, Cultured; Histamine; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Sequence Homology, Amino Acid; Serine; Tyrosine | 2002 |
Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase beta subunit in the energy coupling mechanism of the Na+ pump.
Topics: Amino Acid Substitution; Carboxy-Lyases; Conserved Sequence; Energy Metabolism; Kinetics; Klebsiella pneumoniae; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Structure, Secondary; Protein Subunits; Protons; Serine; Sodium; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2002 |
Homonuclear zero-quantum recoupling in fast magic-angle spinning nuclear magnetic resonance.
Topics: Alanine; Carbon Isotopes; Glycine; Magnetic Resonance Spectroscopy; Mathematics; Serine; Tyrosine | 2002 |
The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways.
Topics: Blotting, Western; CD40 Antigens; Cell Movement; Cells, Cultured; Chemokine CCL2; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Fibrinolysin; Humans; Janus Kinase 1; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinases; Protein-Tyrosine Kinases; Serine; Serine Endopeptidases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcriptional Activation; Tyrosine | 2002 |
D1 dopamine receptor regulation of microtubule-associated protein-2 phosphorylation in developing cerebral cortical neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Dendrites; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Frontal Lobe; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neurites; Neurons; Phosphorylation; Receptors, Dopamine D1; Serine; Signal Transduction; Threonine; Time Factors; Tyrosine | 2002 |
Regulation of phospholipase C-gamma1 by protein kinase A-dependent phosphorylation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; COS Cells; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Gene Expression Regulation, Enzymologic; Immunoblotting; Isoenzymes; Ligands; Mice; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Phospholipase C gamma; Phosphorylation; Plasmids; Precipitin Tests; Protein Kinase C; Protein Structure, Tertiary; Rats; Receptors, Adrenergic, beta-2; Serine; Threonine; Time Factors; Transfection; Type C Phospholipases; Tyrosine | 2002 |
Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.
Topics: 2',5'-Oligoadenylate Synthetase; Adult; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Regulation; GTP-Binding Proteins; Humans; Interferon beta-1a; Interferon beta-1b; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon-beta; Interferons; Leukocytes, Mononuclear; Male; Middle Aged; Multiple Sclerosis; Myxovirus Resistance Proteins; Phosphoproteins; Phosphorylation; Proteins; Repressor Proteins; RNA, Messenger; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factors; Tyrosine; Up-Regulation | 2002 |
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.
Topics: Animals; Arginine; Blotting, Western; Cell Line; DNA-Binding Proteins; Fibroblasts; Humans; Immunoblotting; Interferon-alpha; Interferon-beta; Mice; Mutation; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Protein Tyrosine Phosphatases; Serine; STAT1 Transcription Factor; T-Lymphocytes; Time Factors; Trans-Activators; Transcription, Genetic; Tyrosine | 2002 |
Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Cell Adhesion; Cell Division; Cell Line; Cells, Cultured; Cytochalasin D; Cytoskeleton; Dactinomycin; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Humans; Immunoblotting; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Substrate Specificity; Thiazoles; Thiazolidines; Threonine; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine; Up-Regulation | 2002 |
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; DNA-Binding Proteins; GADD45 Proteins; Interferon-gamma; Interleukin-12; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proteins; Receptors, Interleukin; Receptors, Interleukin-12; Recombinant Proteins; Serine; Signal Transduction; STAT4 Transcription Factor; Th1 Cells; Trans-Activators; Tyrosine | 2002 |
Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Cell Survival; Cytochrome c Group; DNA Damage; DNA Fragmentation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gamma Rays; HL-60 Cells; Humans; Models, Biological; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Time Factors; Tyrosine | 2002 |
Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Crotonates; Dimerization; Dose-Response Relationship, Drug; Electrophysiology; Ethyl Methanesulfonate; GABA Antagonists; Glycine; Humans; Imidazoles; Mesylates; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oocytes; Organophosphorus Compounds; Picrotoxin; Protein Binding; Receptors, GABA-B; RNA, Complementary; Serine; Transcription, Genetic; Tryptophan; Tyrosine; Xenopus laevis | 2002 |
Biochemical characterization of the Arabidopsis protein kinase SOS2 that functions in salt tolerance.
Topics: Adaptation, Physiological; Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Cations, Divalent; Enzyme Activation; Escherichia coli; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glutathione Transferase; Hydrogen-Ion Concentration; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Substrate Specificity; Tyrosine | 2002 |
The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis.
Topics: Apoptosis; Binding Sites; DNA-Binding Proteins; Eukaryotic Cells; Heat-Shock Response; Hot Temperature; Humans; Ischemia; Mutation; Phosphorylation; Protein Structure, Tertiary; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Stress, Physiological; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine | 2002 |
Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Apoptosis; Bungarotoxins; Caspase 3; Caspases; Enzyme Activation; Enzyme Inhibitors; Humans; Janus Kinase 2; Neuroprotective Agents; Nicotine; Nicotinic Agonists; PC12 Cells; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, Nicotinic; Serine; Signal Transduction; Tyrosine; Tyrphostins | 2002 |
Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Enzyme Activation; Epitopes; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Probing Src homology 2 domain ligand interactions by differential line broadening.
Topics: Isoleucine; Leucine; Ligands; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylinositol 3-Kinases; Proline; Protein Subunits; Serine; src Homology Domains; Tyrosine | 2002 |
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Cell Line; Cell Nucleus; Cells, Cultured; DNA; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Gene Expression Regulation; Glutathione Transferase; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Luciferases; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Sequence Homology, Amino Acid; Serine; STAT1 Transcription Factor; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2002 |
Signal transducers and activators of transcription as downstream targets of nongenomic estrogen receptor actions.
Topics: Animals; Caseins; COS Cells; Cytoplasm; DNA-Binding Proteins; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Genome; Milk Proteins; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Receptors, Estrogen; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2002 |
Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Antisense Elements (Genetics); Cell Membrane; Cells, Cultured; Feedback, Physiological; Fibroblasts; Humans; Insulin; Molecular Sequence Data; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tyrosine | 2002 |
Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor.
Topics: Caveolin 1; Caveolins; Cell Line; Cell Membrane; Cytoplasm; Detergents; Dimerization; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Immunoblotting; Keratinocytes; Models, Chemical; Oligonucleotides, Antisense; Phosphorylation; Precipitin Tests; Protein Binding; Serine; Signal Transduction; Tyrosine; Up-Regulation | 2002 |
DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosis; Blotting, Western; Cell Death; Cell Line; Cell Survival; COS Cells; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cytokines; DNA, Complementary; Dyrk Kinases; Flow Cytometry; Genes, Reporter; HeLa Cells; Hematopoietic Stem Cells; Humans; Mice; Models, Biological; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine | 2002 |
Mutations in the putative pore-forming segment favor short-lived wild-type Kir2.1 pore conformations.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Cysteine; Glycosylation; Ion Channel Gating; Isoleucine; Mice; Molecular Sequence Data; Patch-Clamp Techniques; Peptide Fragments; Phenylalanine; Point Mutation; Potassium Channels, Inwardly Rectifying; Protein Conformation; Protein Structure, Tertiary; Serine; Spodoptera; Threonine; Time Factors; Tyrosine | 2002 |
PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site.
Topics: Amino Acid Sequence; Animals; beta Catenin; Binding Sites; Binding, Competitive; Cadherins; Cell Membrane; Chick Embryo; Cytoplasm; Cytoskeletal Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Gene Deletion; Glutathione Transferase; Green Fluorescent Proteins; Immunoblotting; Luminescent Proteins; Microscopy, Confocal; Molecular Sequence Data; Peptides; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Retina; Serine; Time Factors; Trans-Activators; Transfection; Tyrosine | 2002 |
Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation.
Topics: Antibodies, Monoclonal; Binding Sites; Epitope Mapping; Epitopes; Escherichia coli; Glutathione Transferase; Humans; Mutation; Peptide Fragments; Peptides; Phosphorylation; Protein Binding; Proto-Oncogene Proteins; Recombinant Proteins; Serine; Tumor Suppressor Protein p53; Tyrosine | 2002 |
ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serine; Signal Transduction; Transfection; Tyrosine | 2002 |
Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies.
Topics: Alanine; Animals; Cell Line; Cell Movement; Chemokine CCL5; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Hydrogen-Ion Concentration; Immunoblotting; Immunoenzyme Techniques; Ligands; Microscopy, Fluorescence; Mutation; Pertussis Toxin; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Receptors, CCR5; Serine; Time Factors; Tumor Cells, Cultured; Tyrosine | 2003 |
CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors.
Topics: Cell Nucleus; Cells, Cultured; Dendritic Cells; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon Regulatory Factor-3; Interferon Regulatory Factor-7; Interferon-alpha; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Kinetics; Mitogen-Activated Protein Kinases; Models, Immunological; Oligodeoxyribonucleotides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger; Serine; STAT1 Transcription Factor; STAT2 Transcription Factor; Stem Cells; Trans-Activators; Transcription Factors; Tyrosine | 2002 |
Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion.
Topics: Apoptosis; Base Sequence; Cell Lineage; DNA Primers; HeLa Cells; Humans; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; RNA, Antisense; Serine; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Ultraviolet Rays; Vanadates | 2002 |
Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide.
Topics: Alkynes; Amino Acid Sequence; Animals; Arginine; Binding Sites; Cell Line; Chromatography, High Pressure Liquid; Cyanogen Bromide; Cyclooxygenase 2; Enzyme Inhibitors; Heptanes; Hydrogen; Hydrogen Bonding; Insecta; Isoenzymes; Ligands; Mass Spectrometry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Prostaglandin-Endoperoxide Synthases; Protein Conformation; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfides; Tyrosine | 2003 |
Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours.
Topics: Blotting, Western; Cell Transformation, Neoplastic; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Interleukin-10; Lymphoma, Mantle-Cell; Neoplasm Proteins; Phosphorylation; Serine; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2003 |
Mechanism of the reductive half-reaction in cellobiose dehydrogenase.
Topics: Binding Sites; Carbohydrate Dehydrogenases; Cellobiose; Cholesterol Oxidase; Crystallography, X-Ray; Fungi; Glucose Oxidase; Hydrogen; Lactams; Ligands; Models, Chemical; Models, Molecular; Oxygen; Phanerochaete; Protein Conformation; Protein Structure, Secondary; Serine; Tyrosine | 2003 |
Chromophore environment provides clue to "kindling fluorescent protein" riddle.
Topics: Alanine; Animals; Cloning, Molecular; Escherichia coli; Green Fluorescent Proteins; Luminescent Proteins; Microscopy, Fluorescence; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Sea Anemones; Serine; Spectrophotometry; Tyrosine | 2003 |
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin Receptor Substrate Proteins; Liver; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Oligonucleotides, Antisense; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Signal Transduction; Tyrosine | 2003 |
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
Topics: Allosteric Site; Amino Acid Sequence; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Dose-Response Relationship, Drug; Hydrogen Bonding; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nitrogen; Nucleosides; Oxygen; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Tyrosine; Viral Nonstructural Proteins | 2003 |
Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity.
Topics: Amino Acid Sequence; Animals; Asparagine; Binding Sites; Cell Membrane; Cloning, Molecular; Diterpenes; DNA, Complementary; Electrophysiology; Kinetics; Models, Chemical; Molecular Sequence Data; Muscle Proteins; Mutagenesis, Site-Directed; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Phenylalanine; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; Serine; Sodium Channels; Transfection; Tyrosine | 2003 |
Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.
Topics: 3-Deoxy-7-Phosphoheptulonate Synthase; Alleles; Amino Acid Sequence; Amino Acids; Crystallography, X-Ray; Enzymes; Glycine; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Serine; Tyrosine | 2003 |
Structure and kinetic properties of Paracoccus pantotrophus cytochrome cd1 nitrite reductase with the d1 heme active site ligand tyrosine 25 replaced by serine.
Topics: Binding Sites; Cytochromes; Electron Transport Complex IV; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Heme; Kinetics; Ligands; Mutagenesis; Nitrite Reductases; Paracoccus; Protein Structure, Tertiary; Serine; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2003 |
Phosphorylation of serine residues is fundamental for the calcium-binding ability of Orchestin, a soluble matrix protein from crustacean calcium storage structures.
Topics: Amino Acid Sequence; Animals; Calcification, Physiologic; Calcium; Calcium-Binding Proteins; Crustacea; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Serine; Structure-Activity Relationship; Tyrosine | 2003 |
Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2).
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Brain; Detergents; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Lipid Metabolism; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Membrane Microdomains; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Octoxynol; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Serine; Signal Transduction; Threonine; Time Factors; Tumor Cells, Cultured; Tyrosine | 2003 |
Dimerization and signal transduction of the growth hormone receptor.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cricetinae; Cricetulus; Dimerization; Endopeptidases; Ligands; Point Mutation; Protein Conformation; Protein Structure, Tertiary; Rabbits; Receptors, Somatotropin; Serine; Signal Transduction; Tyrosine | 2003 |
Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP.
Topics: Adenosine Diphosphate; Adolescent; Adult; Benzylamines; Blood Platelets; Clopidogrel; Electrophoresis, Polyacrylamide Gel; Humans; Male; Membrane Proteins; Phosphorylation; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serine; Signal Transduction; Thiazoles; Thionucleotides; Threonine; Ticlopidine; Tyrosine | 2003 |
Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
Topics: Antibodies, Monoclonal; Blotting, Western; Cell Line; Cross-Linking Reagents; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Enzymologic; Humans; Integrins; Jurkat Cells; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Biological; Mutation; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Serine; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tyrosine | 2003 |
O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase.
Topics: Amino Acid Substitution; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Ferrous Compounds; Free Radicals; Iron; Isoleucine; Ketoglutaric Acids; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Oxygen; Oxygenases; Recombinant Proteins; Serine; Spectrophotometry; Spectrum Analysis, Raman; Time Factors; Tyrosine | 2003 |
Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation.
Topics: 3T3 Cells; Adenoviridae; Animals; Cell Division; Cell Line; Cloning, Molecular; COS Cells; Enzyme Activation; Fibroblast Growth Factors; Gene Expression Regulation, Enzymologic; Genetic Vectors; Humans; Immunoblotting; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Serine; Signal Transduction; Threonine; Thymidine; Tyrosine | 2003 |
Serine 338 phosphorylation is dispensable for activation of c-Raf1.
Topics: Androstadienes; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Glutathione Transferase; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; Signal Transduction; Time Factors; Tyrosine; U937 Cells; Wortmannin | 2003 |
Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.
Topics: Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interphase; Phosphorylation; Proto-Oncogene Proteins c-myc; RNA, Messenger; Serine; STAT1 Transcription Factor; Trans-Activators; Tretinoin; Tumor Suppressor Proteins; Tyrosine; U937 Cells | 2003 |
Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold.
Topics: Animals; Blood Glucose; Cold Temperature; Eating; Fatty Acids, Nonesterified; Hormones; Hypoglycemic Agents; Hypothalamus; Immunoblotting; Injections, Intraventricular; Insulin; Insulin Resistance; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Rats; Rats, Wistar; Satiety Response; Serine; Signal Transduction; Tyrosine | 2003 |
Actin tyrosine dephosphorylation by the Src homology 1-containing protein tyrosine phosphatase is essential for actin depolymerization after membrane IgM cross-linking.
Topics: Actins; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; Chickens; Cross-Linking Reagents; Cysteine; Humans; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Polymers; Protein Binding; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Antigen, B-Cell; Serine; src Homology Domains; Substrate Specificity; Transfection; Tyrosine | 2003 |
Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium.
Topics: Calcium; Calcium Signaling; CD11 Antigens; Cell Adhesion; Chemotaxis; Cytosol; Enzyme Activation; Humans; Intercellular Signaling Peptides and Proteins; Lactoferrin; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Pancreatic Elastase; Peroxidase; Pertussis Toxin; Phosphorylation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Peptide; Serine; Tyrosine | 2003 |
Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.
Topics: Animals; Base Sequence; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cloning, Molecular; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Humans; Mice; Osteoclasts; Osteopontin; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; RNA, Messenger; Serine; Sialoglycoproteins; Signal Transduction; Subcellular Fractions; Transcription Factors; Transduction, Genetic; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling.
Topics: Animals; CHO Cells; Computer Simulation; Cricetinae; Enzyme Inhibitors; ErbB Receptors; Kinetics; Ligands; Mitogen-Activated Protein Kinases; Models, Molecular; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Receptor Cross-Talk; Receptor, ErbB-4; Serine; Signal Transduction; Tyrosine | 2003 |
Cloning and characterization of the 82 kDa tyrosine-rich sexual stage glycoprotein, GAM82, and its role in oocyst wall formation in the apicomplexan parasite, Eimeria maxima.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Chickens; DNA, Complementary; Eimeria; Gene Expression Regulation, Developmental; Glycoproteins; Molecular Sequence Data; Molecular Weight; Protozoan Proteins; RNA, Protozoan; Sequence Alignment; Sequence Analysis, DNA; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Serine; Tyrosine | 2003 |
Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.
Topics: Active Transport, Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Precursors; Humans; Hydrogen Peroxide; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; NF-kappa B; Phosphorylation; Protein-Tyrosine Kinases; Serine; Syk Kinase; Transcription Factor RelA; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Different short- and long-term effects of resveratrol on nuclear factor-kappaB phosphorylation and nuclear appearance in human endothelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; NF-kappa B; NF-kappa B p50 Subunit; Phosphorylation; Resveratrol; Serine; Signal Transduction; Stilbenes; Transcription Factor RelA; Transcription, Genetic; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Structural basis for variation in adenovirus affinity for the cellular coxsackievirus and adenovirus receptor.
Topics: Adenoviridae; Amino Acid Sequence; Anisotropy; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Crystallography, X-Ray; Hydrogen Bonding; Kinetics; Ligands; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, Virus; Recombinant Proteins; Serine; Tyrosine | 2003 |
Preparation of self-assembled silk sericin nanoparticles.
Topics: Circular Dichroism; Infrared Rays; Insect Proteins; Light; Magnetic Resonance Spectroscopy; Microscopy, Electron; Microscopy, Electron, Scanning; Peptides, Cyclic; Polyethylene Glycols; Protein Binding; Protein Conformation; Scattering, Radiation; Sericins; Serine; Silk; Tyrosine | 2003 |
Nuclear translocation of Xenopus laevis paxillin.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apigenin; Cell Cycle; Cell Fractionation; Cell Line; Cytoskeletal Proteins; Fibronectins; Flavonoids; Integrins; Laminin; Mitogen-Activated Protein Kinases; Models, Biological; Paxillin; Phosphoproteins; Phosphorylation; Serine; Tyrosine; Vitronectin; Xenopus laevis; Xenopus Proteins | 2003 |
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptor, Insulin; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine | 2003 |
Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium.
Topics: Active Transport, Cell Nucleus; Animals; Cell Membrane; Cell Nucleus; Cytoskeleton; Female; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heart Failure; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Myocytes, Cardiac; Phosphorylation; Protein Transport; Protein-Tyrosine Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serine; Tyrosine | 2003 |
Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Androstadienes; Animals; Apoptosis; Blotting, Northern; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cloning, Molecular; COS Cells; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Glutathione Transferase; Humans; Immunoblotting; In Situ Nick-End Labeling; Ki-1 Antigen; Lymphoma, Large B-Cell, Diffuse; Mice; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoamino Acids; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Signal Transduction; Time Factors; Tissue Distribution; Transfection; Two-Hybrid System Techniques; Type C Phospholipases; Tyrosine; Wortmannin | 2003 |
Regulation and substrate specificity of the SR protein kinase Clk/Sty.
Topics: Blotting, Western; Cell Line; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Humans; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; RNA Splicing; Serine; Subcellular Fractions; Substrate Specificity; Transfection; Tyrosine | 2003 |
Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon alpha-2; Interferon-alpha; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lovastatin; Mevalonic Acid; Phosphorylation; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Serine; Threonine; Time Factors; Tyrosine | 2003 |
Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Janus Kinase 2; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Molecular Mimicry; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Serine; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Cardioprotection involves activation of NF-kappa B via PKC-dependent tyrosine and serine phosphorylation of I kappa B-alpha.
Topics: Animals; I-kappa B Kinase; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Isoenzymes; Myocardium; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rabbits; Serine; Tyrosine | 2003 |
High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Topics: Animals; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Muscle, Skeletal; Palmitic Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptor, Insulin; Serine; Sphingosine; Tyrosine | 2003 |
A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Glucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Male; Morpholines; Muscle Contraction; Muscle, Skeletal; Organometallic Compounds; Phenanthrolines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Physical Exertion; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Tyrosine; Vanadates; Wortmannin | 2003 |
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide.
Topics: Acetylation; Amino Acids; Animals; Arachidonic Acids; Binding Sites; Cannabinoid Receptor Modulators; Cannabinoids; Catalysis; Cyclooxygenase 1; Cyclooxygenase 2; Endocannabinoids; Fatty Acids, Unsaturated; Hydrophobic and Hydrophilic Interactions; Hydroxyeicosatetraenoic Acids; Isoenzymes; Male; Membrane Proteins; Methionine; Mice; Mutagenesis, Site-Directed; Oxygen; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Serine; Sheep; Substrate Specificity; Tyrosine | 2003 |
Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Blotting, Western; Brain; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Family Health; Female; Glutamine; Histidine; Humans; Immunohistochemistry; Membrane Proteins; Mutation, Missense; Pedigree; Peptide Fragments; Plaque, Amyloid; Presenilin-1; Serine; Tyrosine | 2003 |
Interleukin 1 (IL-1) induces the activation of Stat3.
Topics: Base Sequence; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Interleukin-1; Molecular Sequence Data; Oligonucleotides; Phosphorylation; Serine; STAT3 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase.
Topics: Amino Acid Substitution; Animals; Binding Sites; Hypoxanthine Phosphoribosyltransferase; Kinetics; Mutagenesis, Site-Directed; Mutation; Serine; Structure-Activity Relationship; Trypanosoma cruzi; Tyrosine | 2003 |
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arginine; Binding, Competitive; Cell Line; Crystallography, X-Ray; Cyclooxygenase 2; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insecta; Isoenzymes; Mice; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Piroxicam; Prostaglandin-Endoperoxide Synthases; Protein Binding; Serine; Sulfonamides; Time Factors; Tyrosine | 2003 |
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; COS Cells; ErbB Receptors; Feedback, Physiological; Humans; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Receptors, Fibroblast Growth Factor; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Threonine; Tyrosine | 2003 |
Metabolism of phenylalanine and tyrosine by Escherichia coli strain K-12.
Topics: Escherichia coli; Phenylalanine; Serine; Tyrosine | 1954 |
Amino acid composition and electrophoretic properties of hypertensin I.
Topics: Amino Acids; Angiotensin Amide; Angiotensins; Arginine; Aspartic Acid; Glycine; Histidine; Isoleucine; Leucine; Phenylalanine; Proline; Serine; Tyrosine; Valine | 1955 |
The nutrition of animal tissues cultivated in vitro. IV. Amino acid requirements of chick embryonic heart fibroblasts.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Chickens; Cystine; Fibroblasts; Glycine; Histidine; Hydroxyproline; In Vitro Techniques; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Threonine; Tissue Culture Techniques; Tryptophan; Tyrosine; Valine | 1957 |
The amino acid requirements of rabbit fibroblasts, strain RM3-56.
Topics: Alanine; Amino Acids; Animals; Arginine; Cystine; Fibroblasts; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Rabbits; Serine; Threonine; Tissue Culture Techniques; Tryptophan; Tyrosine; Valine | 1957 |
Latent viral infection of cells in tissue culture. VI. Role of amino acids, glutamine, and glucose in psittacosis virus propagation in L cells.
Topics: Amino Acids; Arginine; Chlamydophila psittaci; Glucose; Glutamine; Lysine; Psittacosis; Serine; Tryptophan; Tyrosine | 1958 |
Nematode biochemistry. II. Biosynthesis of amino acids.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Nematoda; Serine; Threonine; Tyrosine; Valine | 1962 |
[Thin layer chromatographic separation of amino acids on cellulose layers].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Cellulose; Chromatography; Cystine; Glutamates; Glycine; Isoleucine; Leucine; Lysine; Methionine; Serine; Tryptophan; Tyrosine; Valine | 1962 |
Fractionation of soluble RNA by chromatography on DEAE ion exchangers.
Topics: Chromatography; Ethanolamines; Leucine; Phenylalanine; RNA; Serine; Tyrosine; Valine | 1963 |
VARIATION OF FREE AMINO ACIDS IN CORCYRA CEPHALONICA ST. (RICE MOTH LARVAE) DURING SOME B VITAMIN DEFICIENCIES.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chromatography; Glutamates; Glycine; Insecta; Larva; Leucine; Moths; Niacin; Phenylalanine; Research; Riboflavin Deficiency; Serine; Thiamine Deficiency; Tyrosine; Valine; Vitamin B 6 Deficiency; Vitamin B Deficiency | 1963 |
STUDIES ON COLLETOTRICHUM CAPSICI III. THE EFFECT OF INITIAL PH ON THE GROWTH AND AMINO ACID COMPOSITION.
Topics: Alanine; Amino Acids; Aminobutyrates; Arginine; Aspartic Acid; Chromatography; Colletotrichum; Cysteine; Fungi; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Phenylalanine; Research; Serine; Tyrosine | 1963 |
SPECIFICITY OF PEPSIN AND ITS DEPENDENCE ON A POSSIBLE 'HYDROPHOBICBINDING SITE'.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pepsin A; Peptides; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine; Valine | 1963 |
GAS CHROMATOGRAPHY OF AMINO ACIDS. 1. ANALYSIS OF THE MIXTURE OF METHYL-NTRIFLUOROACETYL DERIVATIVES.
Topics: Alanine; Amino Acids; Aspartic Acid; Chromatography; Chromatography, Gas; Fluoroacetates; Glutamates; Glycine; Hydroxyproline; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1963 |
AMINO-ACID CONFIGURATION OF MYCOBACILLIN.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Antifungal Agents; Aspartic Acid; Chemistry Techniques, Analytical; Glutamates; Leucine; Mycobacillin; Proline; Research; Serine; Tyrosine | 1963 |
[ON THE QUANTITATIVE DETERMINATION OF AMINO ACIDS USING HIGH VOLTAGE ELECTROPHORESIS].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Blood Protein Electrophoresis; Glutamates; Histidine; Leucine; Lysine; Methionine; Ornithine; Proline; Research; Serine; Threonine; Tyrosine; Valine | 1963 |
[CONTRIBUTION TO THE STUDY OF RIBONUCLEOPROTEINS OF NORMAL AND NEOPLASTIC TISSUES].
Topics: Alanine; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Glycine; Isoleucine; Leucine; Liver; Lysine; Mice; Neoplasm Proteins; Neoplasms; Nucleoproteins; Phenylalanine; Rats; Research; Ribonucleoproteins; RNA; RNA, Neoplasm; Serine; Threonine; Tyrosine; Valine | 1963 |
[SPECIFICITY OF ACTIVATION ENZYMES WITH RESPECT TO RIBONUCLEIC ACIDS ESTERIFIED BY AMINO ACIDS].
Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Ligases; Methionine; Nucleoproteins; Poultry; Proteins; Research; RNA; RNA, Bacterial; Serine; Sulfur Isotopes; Tyrosine | 1963 |
BIOCHEMISTRY OF LUNGS IN RELATION TO SILICOSIS. II. THE EFFECT OF QUARTZ DUST ON THE PROTEIN AMINO ACIDS OF GUINEA PIG LUNG TISSUE.
Topics: Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Collagen; Cystine; Dust; Glutamates; Glycine; Guinea Pigs; Histidine; Hydroxyproline; Isoleucine; Leucine; Lung; Lysine; Methionine; Phenylalanine; Proline; Quartz; Research; Serine; Silicon Dioxide; Silicosis; Threonine; Toxicology; Tyrosine; Valine | 1964 |
A DETERMINATION OF THE ESSENTIAL AMINO ACID PROPORTIONS NEEDED TO ALLOW RAPID GROWTH IN CHICKS.
Topics: Amino Acids; Amino Acids, Essential; Animals; Animals, Newborn; Arginine; Caseins; Chickens; Cystine; Diet; Dietary Proteins; Glutamates; Growth; Histidine; Isoleucine; Leucine; Lysine; Methionine; Nitrogen; Phenylalanine; Poultry; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
RELATIVE POTENCY OF DIETS CONTAINING AMINO ACIDS AND PROTEINS FOR PROMOTING GROWTH OF RATS.
Topics: Albumins; Amino Acids; Animals, Newborn; Arginine; Cystine; Diet; Dietary Proteins; Glutamates; Glycine; Growth; Histidine; Isoleucine; Leucine; Lysine; Methionine; Nitrogen; Phenylalanine; Proteins; Rats; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
ASPECTS OF CHEMORECEPTION IN CRUSTACEA.
Topics: Aminobutyrates; Animals; Aspartic Acid; Crustacea; Cysteine; Electrophysiology; Glutamates; Glutathione; Glycine; Glycogen; Histamine; Indoles; Leucine; Methionine; Muscles; Pharmacology; Research; Sensory Receptor Cells; Serine; Tyrosine; Urea | 1963 |
SOME CHARACTERISTICS OF THE SHEEP THYROID GLAND SYSTEM FOR INCORPORATING AMINO ACIDS INTO PROTEIN.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Arginine; Aspartic Acid; Carbon Isotopes; Glucose; Glutamates; Glycine; Ketoglutaric Acids; Leucine; Phenylalanine; Physiology; Proteins; Pyruvates; Research; Serine; Sheep; Succinates; Thyroid Gland; Thyrotropin; Tyrosine; Valine | 1964 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
THE ROLE OF DISPENSABLE AMINO ACIDS IN THE NUTRITION OF THE RAT.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Bicarbonates; Caseins; Cystine; Dietary Proteins; Glutamates; Glycine; Growth; Histidine; Isoleucine; Lysine; Methionine; Phenylalanine; Proline; Proteins; Rats; Research; Serine; Tyrosine | 1964 |
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; Glycine; Guinea Pigs; Histidine; Leucine; Lysine; Nerve Tissue Proteins; Nervous System; Phenylalanine; Research; Serine; Spinal Cord; Threonine; Tyrosine; Valine | 1964 |
POLYNUCLEOTIDE ANALOGUES. II. STIMULATION OF AMINO ACID INCORPORATION BY POLYNUCLEOTIDE ANALOGUES.
Topics: Amino Acids; Carbon Isotopes; Chromatography; Cysteine; Escherichia coli; Glycine; Isoleucine; Leucine; Lysine; Pharmacology; Phenylalanine; Polynucleotides; Proline; Proteins; Research; Serine; Threonine; Tryptophan; Tyrosine; Uracil Nucleotides; Valine | 1964 |
MIGRATION OF AMINO ACIDS ACROSS THE MEMBRANE OF THE HUMAN ERYTHROCYTE.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Carbon Isotopes; Erythrocytes; Glycine; Histidine; Leucine; Methionine; Permeability; Phenylalanine; Proteins; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
DYNAMIC PHENOMENA IN MICROSPHERES FROM THERMAL PROTEINOID.
Topics: Alanine; Arginine; Aspartic Acid; Colloids; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Microspheres; Peptides; Phenylalanine; Photomicrography; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
[SEPARATION OF AMINO ACIDS BY CHROMATOGRAPHY ON THIN LAYERS OF DIETHYLAMINOETHYL CELLULOSE].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cellulose; Chromatography; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
CHROMATOGRAPHIC SEPARATION OF PYRIDOXYL DERIVATIVES OF AMINO ACIDS.
Topics: Alanine; Amines; Amino Acids; Arginine; Aspartic Acid; Chromatography; Glutamates; Glycine; Histidine; Leucine; Lysine; Methionine; Phenylalanine; Pyridines; Pyridoxine; Research; Serine; Threonine; Tyrosine; Valine | 1964 |
SERUM AMINO ACIDS IN KWASHIORKOR. I. RELATIONSHIP TO CLINICAL CONDITION.
Topics: Alanine; Amino Acids; Biomedical Research; Black People; Blood; Glutamates; Glutamine; Glycine; Infant; Isoleucine; Kwashiorkor; Leucine; Methionine; Phenylalanine; Serine; Threonine; Tyrosine; Uganda; Valine | 1964 |
DIFFERENCES IN CHLORAMPHENICOL SENSITIVITY OF CELL-FREE AMINO ACID POLYMERIZATION SYSTEMS.
Topics: Adenine Nucleotides; Amino Acids; Antimetabolites; Carbon Isotopes; Cell-Free System; Chloramphenicol; Escherichia coli; Isoleucine; Leucine; Micrococcus; Nucleoproteins; Nucleotidases; Pharmacology; Phenylalanine; Plant Viruses; Polymerization; Polynucleotides; Proteins; Research; RNA; RNA, Bacterial; RNA, Messenger; RNA, Viral; Serine; Tyrosine; Uracil Nucleotides | 1964 |
A SIMPLE PREPARATION METHOD FOR DIPHOSPHOMIDAZOLE.
Topics: Alanine; Amides; Calcium Phosphates; Chlorides; Chromatography; Cysteine; Cystine; Glycine; Histidine; Imidazoles; Ion Exchange Resins; Methionine; Phosphates; Phosphorus; Research; Serine; Tryptophan; Tyrosine | 1964 |
SYNTHESIS OF AMINO ACIDS IN THE CATECHOLAMINE SERIES.
Topics: Amino Acids; Catecholamines; Chemistry, Pharmaceutical; Pharmacy; Research; Serine; Tyrosine | 1964 |
[FREE PLASMA AMINO ACIDS IN LIVER CIRRHOSIS AND HEPATITIS].
Topics: Alanine; Amino Acids; Blood; Chromatography; Glutamine; Glycine; Hepatitis; Humans; Ion Exchange Resins; Liver Cirrhosis; Methionine; Phenylalanine; Proline; Serine; Taurine; Threonine; Tyrosine | 1964 |
MYOGLOBIN FREE-RADICALS.
Topics: Alanine; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Glycine; Histidine; Hydrogen Peroxide; Leucine; Myoglobin; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
AMINO ACID CODING IN A SUBCELLULAR SYSTEM DERIVED FROM THE L1210 MOUSE ASCITES LEUKEMIA.
Topics: Adenine Nucleotides; Amino Acids; Animals; Ascites; Genetic Code; Isoleucine; Leucine; Leukemia L1210; Lysine; Neoplasm Proteins; Phenylalanine; Proteins; Research; Serine; Tyrosine; Valine | 1964 |
SOME PROPERTIES OF METHANOBACTERIUM OMELIANSKII FERREDOXIN.
Topics: Alanine; Amino Acids; Aspartic Acid; Bacteria; Chemistry Techniques, Analytical; Cystine; Ferredoxins; Glutamates; Glycine; Iron; Lysine; Methanobacterium; Proline; Serine; Spectrophotometry; Sulfides; Threonine; Tyrosine; Valine | 1964 |
FUNCTION-SPECIFIC CHANGES IN THE METABOLISM OF AGOUTI PIGMENT CELLS.
Topics: Animals; Chromatophores; Cysteine; Dasyproctidae; Dihydroxyphenylalanine; Glutathione; Hair; Leucine; Melanins; Metabolism; Mice; Research; Serine; Sulfhydryl Compounds; Tyrosine | 1964 |
AMINO ACIDS AS PROTECTIVE COMPOUNDS IN ULTRAVIOLET-IRRADIATED HANSENULA WINGEI.
Topics: Alanine; Amino Acids; Arginine; Cysteine; Cystine; Ethionine; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Pichia; Proline; Radiation-Protective Agents; Research; Serine; Threonine; Tryptophan; Tyrosine; Ultraviolet Rays; Valine; Yeasts | 1964 |
LACK OF FIDELITY IN THE TRANSLATION OF SYNTHETIC POLYRIBONUCLEOTIDES.
Topics: Bacillus; Dihydrostreptomycin Sulfate; Isoleucine; Leucine; Magnesium; Metabolism; Nucleotides; Phenylalanine; Polyribonucleotides; Proteins; Research; RNA; RNA, Messenger; Serine; Spermine; Temperature; Tyrosine; Valine | 1964 |
THE INFLUENCE OF ETHIONINE, METHIONINE, CHOLINE, AND RELATED COMPOUNDS ON LIVER GLYCOGEN DEPOSITION IN ADRENALECTOMIZED RATS: RELATION TO THE MODE OF ACTION OF GLUCOCORTICOIDS.
Topics: Adrenalectomy; Choline; Cysteine; Ethionine; Glucocorticoids; Glucose; Homocysteine; Hydrocortisone; Liver; Liver Glycogen; Methionine; Pharmacology; Research; Serine; Tyrosine | 1964 |
THE MACROMOLECULAR ORGANIZATION OF DENTINE MATRIX COLLAGEN. II. PERIODATE DEGRADATION AND CARBOHYDRATE CROSS-LINKING.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Carbohydrates; Cattle; Chemistry Techniques, Analytical; Collagen; Dentin; Electrophoresis; Glutamates; Hexoses; Histidine; Humans; Hydroxyproline; Molecular Weight; Nitrogen; Oxidation-Reduction; Peptides; Periodic Acid; Phosphates; Research; Serine; Skin; Solubility; Tyrosine | 1964 |
[APPLICATION OF THIN-LAYER CHROMATOGRAPHY TO SEQUENCE ANALYSIS OF PEPTIDES. 3. NONDESTRUCTIVE DETECTION OF AMINO ACIDS ON THE THIN-LAYER CHROMATOGRAM].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Chromatography; Chromatography, Thin Layer; Histidine; Peptides; Proline; Research; Sequence Analysis; Serine; Tyrosine; Valine | 1964 |
RAT LIVER ENZYME DOES NOT ACTIVATE ACETYLAMINO ACIDS.
Topics: Acetates; Adenosine Triphosphate; Alanine; Amino Acids; Arginine; Diphosphates; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Liver; Lysine; Methionine; Phenylalanine; Proline; Rats; Research; RNA; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1965 |
EFFECT OF AMINO ACIDS ON GROWTH OF SPHAEROTILUS DISCOPHORUS.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Bacteriological Techniques; Caseins; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Pharmacology; Phenylalanine; Proline; Research; Serine; Sphaerotilus; Threonine; Tryptophan; Tyrosine; Valine | 1965 |
STUDIES ON HUMAN ANTIBODIES. 3. AMINO ACID COMPOSITION OF FOUR ANTIBODIES FROM ONE INDIVIDUAL.
Topics: Alanine; Amino Acids; Antibodies; Arginine; Aspartic Acid; Chemistry Techniques, Analytical; gamma-Globulins; Glutamates; Glycine; Histidine; Immunochemistry; Immunoglobulins; Isoleucine; Leucine; Lysine; Phenylalanine; Serine; Threonine; Tyrosine; Valine | 1965 |
TRIFLUROACETYLATED AMINO ACID ESTERS: THE STABILITY OF THE DERIVATIVES OF CYSTEINE, HYDROXYPROLINE, SERINE, THREONINE AND TYROSINE.
Topics: Acetates; Amino Acids; Chemical Phenomena; Chemistry; Cysteine; Esters; Hydroxyproline; Research; Serine; Threonine; Tyrosine | 1965 |
NEMATODE BIOCHEMISTRY. V. INTERMEDIARY METABOLISM AND AMINO ACID INTERCONVERSIONS IN CAENORHABDITIS BRIGGSAE.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Asparagine; Aspartic Acid; Bicarbonates; Caenorhabditis; Carbon Dioxide; Chromatography; Formates; Glutamates; Glutamine; Glycine; Malates; Nematoda; Phenylalanine; Research; Serine; Taurine; Tyrosine | 1965 |
DETERMINATION OF BACTERIAL DECARBOXYLASES OF SOME AMINO ACIDS BY MEANS OF HIGH VOLTAGE PAPER ELECTROPHORESIS.
Topics: Achromobacter; Amino Acids; Arginine; Aspartic Acid; Bacteria; Carboxy-Lyases; Electrophoresis; Electrophoresis, Paper; Enterobacteriaceae; Escherichia coli; Glutamates; Histidine; Lysine; Ornithine; Phenylalanine; Proteus; Pseudomonas; Serine; Tryptophan; Tyrosine | 1965 |
THE PERIODATE OXIDATION OF AMINO ACIDS WITH REFERENCE TO STUDIES ON GLYCOPROTEINS.
Topics: Amino Acids; Cysteine; Cystine; Glycoproteins; Histidine; Hydrogen-Ion Concentration; Hydroxyproline; Indoles; Isoleucine; Leucine; Methionine; Oxidation-Reduction; Periodic Acid; Phenylalanine; Proline; Pyrroles; Research; Serine; Threonine; Tryptophan; Tyrosine | 1965 |
THE READ-OUT OF TURNIP YELLOW MOSAIC VIRUS RIBONUCLEIC ACID AS A POLYCISTRONIC MESSENGER IN CELL-FREE SYSTEMS OF ESCHERICHIA COLI.
Topics: Cell-Free System; Escherichia coli; Genetic Code; Kinetics; Leucine; Lysine; Methionine; Peptides; Phenylalanine; Plant Viruses; Proteins; Research; Ribosomes; RNA; RNA, Messenger; RNA, Viral; Serine; Threonine; Tymovirus; Tyrosine | 1965 |
Rat growth experiments with beta-phenylserine diastereoisomers.
Topics: Animals; Biological Phenomena; Growth; Phenylalanine; Physiological Phenomena; Rats; Serine; Tyrosine | 1955 |
Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis.
Topics: Animals; Carrier Proteins; Cell Differentiation; Cell Line; Cysteine; Genetic Vectors; Glycoproteins; Intracellular Signaling Peptides and Proteins; Ligands; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; Osteoclasts; Osteoprotegerin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Subunits; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Retroviridae; Serine; src Homology Domains; TNF Receptor-Associated Factor 6; Transduction, Genetic; Tyrosine; Up-Regulation | 2003 |
Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; DNA, Complementary; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrogen Peroxide; Hypoxia; I-kappa B Proteins; Luciferases; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Microscopy, Fluorescence; Models, Biological; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Oxygen; Phosphorylation; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine; Urokinase-Type Plasminogen Activator; Vanadates | 2003 |
Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.
Topics: Blotting, Western; Butadienes; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; cdc42 GTP-Binding Protein; Cell Line; Cell Line, Tumor; Complement C5a; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Genes, Reporter; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Luciferases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phospholipase C beta; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; rac1 GTP-Binding Protein; ras Proteins; rhoA GTP-Binding Protein; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transfection; Type C Phospholipases; Tyrosine | 2003 |
Chemistry. The motions of an enzyme soloist.
Topics: Catalysis; Chemical Phenomena; Chemistry, Physical; Electrons; Escherichia coli; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Fluorescence; FMN Reductase; Hydrogen Bonding; Lasers; Likelihood Functions; Mathematics; Mutation; Photons; Protein Conformation; Serine; Spectrometry, Fluorescence; Temperature; Thermodynamics; Tyrosine | 2003 |
Protein conformational dynamics probed by single-molecule electron transfer.
Topics: Amino Acid Substitution; Catalysis; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Electrons; Escherichia coli; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Fluorescence; FMN Reductase; Hydrogen Bonding; Likelihood Functions; Mathematics; Models, Molecular; Mutagenesis, Site-Directed; Photons; Protein Conformation; Serine; Spectrometry, Fluorescence; Temperature; Thermodynamics; Tyrosine | 2003 |
Oxidative inactivation of purified plasma membrane Ca2+-ATPase by hydrogen peroxide and protection by calmodulin.
Topics: Animals; Calcium-Transporting ATPases; Calmodulin; Cation Transport Proteins; Cattle; Cysteine; Dithiothreitol; Enzyme Activation; Erythrocyte Membrane; Histidine; Humans; Hydrogen Peroxide; Leucine; Oxidation-Reduction; Plasma Membrane Calcium-Transporting ATPases; Protein Conformation; Serine; Spectrometry, Fluorescence; Tyrosine; Valine | 2003 |
Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells.
Topics: Amino Acid Sequence; Animals; Cell Membrane; COS Cells; Enzyme Activation; Humans; Interleukin-2; Jurkat Cells; Molecular Sequence Data; Peptide Mapping; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Serine; Signal Transduction; T-Lymphocytes; Transcriptional Activation; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2003 |
Role of p38alpha Map kinase in Type I interferon signaling.
Topics: Animals; Cell Line, Tumor; Chromatin; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Immunoblotting; Interferon Type I; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Luciferases; Mice; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Osmosis; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Recombinant Proteins; Serine; Signal Transduction; Stress, Physiological; Time Factors; Transcription, Genetic; Transfection; Tyrosine | 2004 |
Cloning and characterization of a GABAA receptor gamma2 subunit variant.
Topics: Alternative Splicing; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cell Membrane; Cloning, Molecular; Exons; Glycine; Humans; Immunohistochemistry; Introns; Microscopy, Fluorescence; Models, Genetic; Molecular Sequence Data; Mutation; Plasmids; Protein Binding; Proteins; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Threonine; Tissue Distribution; Transfection; Tyrosine | 2004 |
The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5.
Topics: Acetylglucosamine; Active Transport, Cell Nucleus; Alanine; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; CREB-Binding Protein; Cytoplasm; Dimerization; DNA-Binding Proteins; Epithelial Cells; Galactosyltransferases; Glycosylation; Growth Substances; Humans; Insecta; Interferons; Lectins; Ligands; Luciferases; Mass Spectrometry; Microscopy, Fluorescence; Milk Proteins; Mutation; Nuclear Proteins; Phosphorylation; Prolactin; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Serine; STAT5 Transcription Factor; Threonine; Trans-Activators; Transcription, Genetic; Transfection; Tumor Suppressor Proteins; Tyrosine | 2004 |
Dimerization inhibitors of HIV-1 protease based on a bicyclic guanidinium subunit.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Circular Dichroism; Dimerization; Guanidines; HIV Protease; HIV Protease Inhibitors; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Protein Structure, Secondary; Serine; Stereoisomerism; Tyrosine | 2003 |
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
Topics: Amino Acid Substitution; Animals; ErbB Receptors; Ligands; Mice; Mutation; NIH 3T3 Cells; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Serine; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Expression of phosphorylation of N-methyl-D-aspartate receptor subunits during graded hypoxia in the cerebral cortex of newborn piglets.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Hypoxia; Phosphocreatine; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Serine; Swine; Threonine; Tyrosine | 2004 |
Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells.
Topics: Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Liver Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine | 2003 |
Hydrogen bonding alteration of Thr-204 in the complex between pharaonis phoborhodopsin and its transducer protein.
Topics: Alanine; Amino Acid Substitution; Archaeal Proteins; Carotenoids; Deuterium Oxide; Halorhodopsins; Hydrogen Bonding; Natronobacterium; Phenylalanine; Photoreceptors, Microbial; Sensory Rhodopsins; Serine; Spectroscopy, Fourier Transform Infrared; Threonine; Tyrosine | 2003 |
Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Topics: Animals; Arginine; Cell Membrane Permeability; In Vitro Techniques; Male; Membrane Proteins; Nasal Mucosa; Occludin; Peptides; Phosphoproteins; Phosphorylation; Rabbits; Serine; Threonine; Tyrosine; Zonula Occludens-1 Protein | 2003 |
Effect of inhibiting vacuolar acidification on insulin signaling in hepatocytes.
Topics: Animals; Antioxidants; Binding Sites; Cell Division; Cell Membrane; Cells, Cultured; Chloroquine; Endosomes; Enzyme Inhibitors; Evolution, Molecular; Glycogen; Hepatocytes; Histidine; Insulin; Macrolides; Male; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Phylogeny; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Superoxides; Swine; Thymidine; Time Factors; Tyrosine | 2004 |
Biophysical analyses of the transthyretin variants, Tyr114His and Tyr116Ser, associated with familial amyloidotic polyneuropathy.
Topics: Amino Acid Substitution; Amyloid; Amyloid Neuropathies, Familial; Dimerization; Electrophoresis, Polyacrylamide Gel; Genetic Variation; Histidine; Humans; Hydrogen-Ion Concentration; Prealbumin; Protein Isoforms; Protein Structure, Quaternary; Serine; Spectrometry, Fluorescence; Tryptophan; Tyrosine; Urea | 2003 |
Determination of the relative energies of activation for the dissociation of aromatic versus aliphatic phosphopeptides by ESI-FTICR-MS and IRMPD.
Topics: Peptide Mapping; Phosphopeptides; Protein Structure, Secondary; Serine; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Tyrosine | 2004 |
Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.
Topics: Adaptor Proteins, Signal Transducing; Adherens Junctions; Binding Sites; Blotting, Western; Caco-2 Cells; Cadherins; Cell Adhesion; Cell Communication; Cell Differentiation; Cell Line; Cytoskeleton; Discs Large Homolog 1 Protein; Epithelial Cells; Genes, Reporter; Humans; Intestinal Mucosa; Intestines; Luciferases; Membrane Proteins; Microscopy, Fluorescence; Models, Genetic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; Signal Transduction; src Homology Domains; Subcellular Fractions; Threonine; Transfection; Tyrosine; Zonula Occludens-1 Protein | 2004 |
The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Angiotensin II; Animals; Apoptosis; Bridged Bicyclo Compounds; Drosophila Proteins; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Neuroprotective Agents; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Receptors, Nicotinic; Serine; Tyrosine; Tyrphostins | 2004 |
Regulation of a gamma-aminobutyric acid transporter by reciprocal tyrosine and serine phosphorylation.
Topics: Animals; Biological Transport; Carrier Proteins; Cells, Cultured; GABA Plasma Membrane Transport Proteins; Hippocampus; Membrane Proteins; Membrane Transport Proteins; Phosphorylation; Rats; Serine; Tyrosine | 2004 |
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.
Topics: Animals; Biological Transport; Blotting, Western; Cell Membrane; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glucose; I-kappa B Kinase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Transport; Rats; Salicylic Acid; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Physiological oxidants induce apoptosis and cell cycle arrest in a multidrug-resistant natural killer cell line, NK-YS.
Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Cell Survival; Chloramines; DNA; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Hydrogen Peroxide; Interleukin-2; Killer Cells, Natural; Oxidants; Phosphorylation; Receptors, Interleukin-2; Recombinant Proteins; Retinoblastoma Protein; Serine; Signal Transduction; Sodium Hypochlorite; Time Factors; Tyrosine | 2003 |
Role of active-site residues Thr81, Ser82, Thr85, Gln157, and Tyr158 in yeast cystathionine beta-synthase catalysis and reaction specificity.
Topics: Alanine; Amino Acid Substitution; Binding Sites; Catalysis; Chromatography, Affinity; Cystathionine beta-Synthase; Glutamine; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Nickel; Phenylalanine; Pyruvic Acid; Saccharomyces cerevisiae Proteins; Serine; Substrate Specificity; Threonine; Tyrosine | 2004 |
Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.
Topics: Active Transport, Cell Nucleus; Binding Sites; Blotting, Western; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Chromatography, Gel; Cyclin B; Glutathione Transferase; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Microscopy, Confocal; Mitosis; Mutagenesis, Site-Directed; Phosphorylation; Plasmids; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Transport; Recombinant Fusion Proteins; RNA, Messenger; RNA, Small Interfering; Serine; Subcellular Fractions; Threonine; Transfection; Tumor Suppressor Proteins; Tyrosine | 2004 |
Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80.
Topics: Anticholesteremic Agents; Biological Transport; Caveolae; Caveolin 1; Caveolins; Cells, Cultured; Cholesterol; Humans; Muscle, Smooth, Vascular; Mutagenesis, Site-Directed; Oligopeptides; Peptides; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Receptors, Platelet-Derived Growth Factor; Serine; Signal Transduction; Tyrosine | 2004 |
Molecular determinants of vanilloid sensitivity in TRPV1.
Topics: Amino Acid Sequence; Animals; Calcium; Capsaicin; Cations; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Spinal; Hot Temperature; Humans; Hydrogen-Ion Concentration; In Situ Hybridization; Inhibitory Concentration 50; Ligands; Methionine; Models, Molecular; Molecular Sequence Data; Mutation; Neurons; Phorbol Esters; Phylogeny; Protein Binding; Protein Structure, Tertiary; Protons; Rabbits; Rats; Receptors, Drug; Sequence Homology, Amino Acid; Serine; Temperature; Threonine; Transfection; Tyrosine | 2004 |
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Glucosamine; Glucose; Hexosamines; Humans; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Serine; TOR Serine-Threonine Kinases; Tyrosine | 2004 |
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity.
Topics: Animals; Down-Regulation; Electroporation; Enzyme Activation; Gene Transfer Techniques; Glycogen Synthase; Humans; Injections, Intramuscular; Insulin Receptor Substrate Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Serine; Tyrosine | 2004 |
AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.
Topics: Animals; Arachidonic Acid; Blotting, Western; Bradykinin; Calcium; COS Cells; Enzyme Activation; Gene Library; Glutathione Transferase; Humans; Inositol Phosphates; Isoenzymes; Membrane Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Neoplasm Proteins; NIH 3T3 Cells; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Serine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Type C Phospholipases; Tyrosine | 2004 |
Rescue of protein splicing activity from a Magnetospirillum magnetotacticum intein-like element.
Topics: Alanine; Alternative Splicing; Catalysis; Cysteine; Magnetospirillum; Models, Genetic; Mutation; Phenylalanine; Polymorphism, Genetic; Protein Splicing; Protein Structure, Tertiary; RNA Splicing; Serine; Tyrosine | 2004 |
Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism.
Topics: Bacterial Toxins; Binding Sites; Cholera Toxin; Crystallization; Crystallography, X-Ray; Enterotoxins; Escherichia coli Proteins; Galactose; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Subunits; Serine; Structure-Activity Relationship; Tyrosine | 2004 |
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; Cell Line; Cricetinae; Humans; Insulin; Insulin Receptor Substrate Proteins; Molecular Chaperones; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Rats; Receptor, Insulin; Serine; Tyrosine | 2004 |
Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function.
Topics: Amino Acid Sequence; DNA; Humans; Interleukin-13; Interleukin-4; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphorylation; Phytohemagglutinins; Protein Phosphatase 2; Serine; STAT6 Transcription Factor; Structure-Activity Relationship; T-Lymphocytes; Trans-Activators; Transcriptional Activation; Tyrosine | 2004 |
Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle.
Topics: Animals; Dietary Proteins; Eating; Insulin; Insulin Receptor Substrate Proteins; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Deficiency; Protein Subunits; Rats; Rats, Wistar; Receptor, Insulin; Serine; Tyrosine | 2004 |
Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor.
Topics: Blotting, Western; Bromodeoxyuridine; Cell Line, Tumor; Coloring Agents; Enzyme Activation; Enzyme Inhibitors; Hepatocyte Growth Factor; Humans; Hydrogen Peroxide; Models, Biological; Oxidative Stress; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Phosphatase 2; Proto-Oncogene Proteins c-met; Serine; Sodium Fluoride; Time Factors; Tyrosine | 2004 |
The crystal structure of the Y66L variant of green fluorescent protein supports a cyclization-oxidation-dehydration mechanism for chromophore maturation.
Topics: Amino Acid Substitution; Animals; Crystallization; Crystallography, X-Ray; Genetic Variation; Green Fluorescent Proteins; Heterocyclic Compounds; Hydrogen Bonding; Imidazoles; Leucine; Luminescent Proteins; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Protein Precursors; Serine; Spectrometry, Mass, Electrospray Ionization; Threonine; Tyrosine | 2004 |
Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D.
Topics: Acetylcysteine; Amino Acid Substitution; Animals; Cell Nucleus; Chlorocebus aethiops; COS Cells; Enzyme Activation; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Protein Kinase C; Recombinant Proteins; Serine; Signal Transduction; Swiss 3T3 Cells; Transfection; Tyrosine | 2004 |
Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils.
Topics: 14-3-3 Proteins; CD18 Antigens; Cell Adhesion; Enzyme Inhibitors; Humans; Indoles; Maleimides; Neutrophils; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Serine; Signal Transduction; src-Family Kinases; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
Requirement of histone deacetylase activity for signaling by STAT1.
Topics: Active Transport, Cell Nucleus; Apoptosis; bcl-X Protein; Blotting, Western; Butyrates; Cell Line; Cell Line, Tumor; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylases; Humans; Hydroxamic Acids; Inflammation; Interferon-gamma; Microscopy, Fluorescence; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; RNA Interference; RNA, Small Interfering; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine; Vorinostat | 2004 |
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.
Topics: Amino Acid Motifs; Animals; Blood Glucose; Blotting, Western; Cell Line; Diabetes Mellitus, Type 2; Glucose; Heterozygote; Humans; Insulin; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2004 |
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; Down-Regulation; Enzyme Inhibitors; Estradiol; Flavonoids; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neurons; Oxidoreductases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Retroviridae; RNA, Small Interfering; Serine; tau Proteins; Temperature; Threonine; Time Factors; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; WW Domain-Containing Oxidoreductase | 2004 |
In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Humans; Insulin; Insulin Antagonists; Insulin Receptor Substrate Proteins; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Protein Subunits; Rats; Receptor, Insulin; Serine; Signal Transduction; Substrate Specificity; Tyrosine | 2004 |
Bacterially expressed recombinant p68 RNA helicase is phosphorylated on serine, threonine, and tyrosine residues.
Topics: Blotting, Western; DEAD-box RNA Helicases; Escherichia coli; Phosphorylation; Protein Kinases; Recombinant Proteins; RNA Helicases; Serine; Threonine; Tyrosine | 2004 |
Lack of evidence for phosphorylation of Arabidopsis thaliana PII: implications for plastid carbon and nitrogen signaling.
Topics: Arabidopsis; Arabidopsis Proteins; Blotting, Western; Carbon; Chloroplasts; Immunoglobulin G; Nitrogen; Phosphoprotein Phosphatases; Phosphorylation; PII Nitrogen Regulatory Proteins; Precipitin Tests; Protein Kinases; Serine; Signal Transduction; Tyrosine | 2004 |
UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain.
Topics: Amino Acid Sequence; Animals; Cytoplasm; Dose-Response Relationship, Radiation; ErbB Receptors; Mice; Molecular Sequence Data; Mutation; NIH 3T3 Cells; Platelet-Derived Growth Factor; Protein Conformation; Protein Transport; Serine; Structure-Activity Relationship; Tissue Distribution; Tyrosine; Ultraviolet Rays | 2004 |
PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation.
Topics: Androstadienes; Animals; Blotting, Western; Butadienes; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Serine; Swiss 3T3 Cells; Tyrosine; Wortmannin | 2004 |
The Phosphorylation Site Database: A guide to the serine-, threonine-, and/or tyrosine-phosphorylated proteins in prokaryotic organisms.
Topics: Archaea; Bacteria; Databases, Factual; Internet; Phosphoproteins; Prokaryotic Cells; Serine; Threonine; Tyrosine | 2004 |
Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.
Topics: Alleles; Binding Sites; Catalysis; Cysteine; Escherichia coli; Galactose; Humans; Models, Biological; Models, Molecular; Mutation; Pichia; Plasmids; Saccharomyces cerevisiae; Serine; Substrate Specificity; Tyrosine; UDPglucose 4-Epimerase; Uridine Diphosphate N-Acetylgalactosamine; Uridine Diphosphate N-Acetylglucosamine | 2004 |
Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.
Topics: Animals; Computer Simulation; Humans; Hydrophobic and Hydrophilic Interactions; Ion Channel Gating; Leucine; Models, Molecular; Phenols; Polyamines; Receptors, Nicotinic; Serine; Spermine; Tyrosine | 2004 |
Structural determinants of HERG channel block by clofilium and ibutilide.
Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis | 2004 |
Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
Topics: Amino Acid Sequence; Blood Platelets; Cell Line; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Green Fluorescent Proteins; Humans; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Microscopy, Confocal; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncogene Proteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C-alpha; Protein Structure, Tertiary; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-vav; Receptor, PAR-1; Receptors, Thrombin; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; src Homology Domains; Substrate Specificity; Thrombin; Tyrosine | 2004 |
Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)).
Topics: Adrenergic Agonists; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cyclic AMP; Humans; Molecular Sequence Data; Mutation; Radioligand Assay; Rats; Receptors, Adrenergic, beta-1; Sequence Homology, Amino Acid; Serine; Tryptophan; Tyrosine | 2004 |
The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11.
Topics: Acetates; Culture Media; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Fungal; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Intracellular Signaling Peptides and Proteins; Meiosis; Nitrogen; Nuclear Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Second Messenger Systems; Serine; Transcription Factors; Transcription, Genetic; Two-Hybrid System Techniques; Tyrosine | 2004 |
Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase.
Topics: 3-Hydroxysteroid Dehydrogenases; Amino Acid Sequence; Base Sequence; Catalysis; Catalytic Domain; DNA Primers; Humans; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Serine; Tyrosine | 2004 |
D-serine-induced nephrotoxicity: possible interaction with tyrosine metabolism.
Topics: Animals; Cyclohexanones; Enzyme Inhibitors; Hydrolases; Kidney Tubules, Proximal; Male; Nitrobenzoates; Phenylpyruvic Acids; Rats; Serine; Tyrosine | 2004 |
Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha.
Topics: Abdomen; Acute Disease; Animals; Hemorrhage; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Rats; Serine; Tumor Necrosis Factor-alpha; Tyrosine; Wounds and Injuries | 2004 |
Activation of formyl peptide receptor-like 1 by WKYMVm induces serine phosphorylation of STAT3, which inhibits its tyrosine phosphorylation and nuclear translocation induced by hydrogen peroxide.
Topics: Biotransformation; Cell Line; Cell Nucleus; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen Peroxide; Immunoblotting; Indicators and Reagents; Luciferases; Mitogen-Activated Protein Kinases; Oligopeptides; Oxidants; p38 Mitogen-Activated Protein Kinases; Phospholipase D; Phosphorylation; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Serine; Signal Transduction; STAT3 Transcription Factor; Stimulation, Chemical; Trans-Activators; Translocation, Genetic; Tyrosine | 2004 |
Infusion of beta-endorphin improves insulin resistance in fructose-fed rats.
Topics: Animals; beta-Endorphin; Diet; Fructose; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Serine; Signal Transduction; Tyrosine | 2004 |
Inhibition of phosphatidylinositol-3-kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R- fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; GRB2 Adaptor Protein; Guanosine Triphosphate; Insulin; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; ras Proteins; Receptor, IGF Type 1; Serine; Signal Transduction; Time Factors; Tyrosine | 2004 |
Enhancement of immunogenicity of an HIV Env DNA vaccine by mutation of the Tyr-based endocytosis motif in the cytoplasmic domain.
Topics: AIDS Vaccines; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Count; Cells, Cultured; Cytoplasm; Endocytosis; Female; HIV; HIV Antibodies; HIV Envelope Protein gp41; HIV Infections; Immunization; Mice; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Serine; Spleen; T-Lymphocytes; Tyrosine; Vaccines, DNA | 2004 |
Characterization of dual specificity protein kinase from maize seedlings.
Topics: Electrophoresis, Gel, Two-Dimensional; Molecular Weight; Phosphopyruvate Hydratase; Phosphorylation; Protein Kinases; Seedlings; Serine; Substrate Specificity; Tyrosine; Zea mays | 2004 |
Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Cell Line; Cell Membrane; DNA Mutational Analysis; Extracellular Space; Humans; Interferon Type I; Ligands; Lysine; Membrane Proteins; Mice; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Receptor, Interferon alpha-beta; Receptors, Interferon; Sequence Homology, Amino Acid; Serine; Signal Transduction; Transfection; Tryptophan; Tyrosine; Valine | 2004 |
Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line.
Topics: Antigens, Neoplasm; Apoptosis; Cell Line; Cell Nucleus; Chromosomes, Human; DNA Topoisomerases, Type II; DNA-Binding Proteins; Doxycycline; Gene Deletion; Genes, Lethal; Genetic Complementation Test; Humans; Mitosis; Mutation; Phosphorylation; Polyploidy; Serine; Tyrosine | 2004 |
Inactivation of glycogen synthase kinase-3beta protects against kainic acid-induced neurotoxicity in vivo.
Topics: Animals; Behavior, Animal; Blotting, Western; Butadienes; Cell Death; Cell Survival; Cerebellum; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Kainic Acid; Lithium Chloride; Male; Mice; Mitogen-Activated Protein Kinase 1; Neurotoxicity Syndromes; Nitriles; Organ Culture Techniques; Phosphorylation; Serine; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine | 2004 |
Identification of the transmembrane metal binding site in Cu+-transporting PIB-type ATPases.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Archaeoglobus fulgidus; Asparagine; Binding Sites; Cation Transport Proteins; Cell Membrane; Conserved Sequence; Copper; Copper-Transporting ATPases; Metals; Methionine; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Phosphates; Phosphorylation; Serine; Structure-Activity Relationship; Tyrosine | 2004 |
Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.
Topics: Adenylyl Cyclases; Animals; Arrestins; beta-Arrestins; Cell Line; Cyclic AMP; Dimerization; Electrophoresis, Polyacrylamide Gel; Endocytosis; Female; Heparin; Humans; Immunoprecipitation; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Muscle Cells; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Polymerase Chain Reaction; Protein Isoforms; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, Corticotropin-Releasing Hormone; Serine; Sheep; Signal Transduction; Threonine; Time Factors; Transfection; Tyrosine | 2005 |
Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor.
Topics: Amino Acid Sequence; Cell Line; Electrophoresis, Gel, Two-Dimensional; Homeodomain Proteins; Humans; LIM-Homeodomain Proteins; Molecular Sequence Data; Phosphorylation; Sequence Homology, Amino Acid; Serine; Threonine; Transcription Factors; Tyrosine | 2005 |
Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.
Topics: Cell Line; Humans; Kidney; MAP Kinase Kinase 6; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Serine; Signal Transduction; Tyrosine | 2005 |
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
Topics: Adipose Tissue; Animals; Body Weight; Epididymis; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Glucose Transporter Type 4; Immunoblotting; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Tissue Distribution; Tyrosine | 2005 |
Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni.
Topics: Alcohol Oxidoreductases; Catalysis; Comamonas testosteroni; Hydrogen-Ion Concentration; Hydroxysteroid Dehydrogenases; Kinetics; Lysine; Mutagenesis, Site-Directed; Serine; Tyrosine | 2005 |
Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; Cell Line; CHO Cells; Cricetinae; DNA, Complementary; Glycogen Synthase Kinase 3; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Lithium; Molecular Sequence Data; Mutation; Peptides; Phosphoproteins; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine | 2005 |
Detection of the site of phosphorylation in a peptide using Raman spectroscopy and partial least squares discriminant analysis.
Topics: Humans; Oncogene Protein pp60(v-src); Peptide Fragments; Phosphorylation; Serine; Spectrum Analysis, Raman; Threonine; Tyrosine | 2005 |
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
Topics: Adenoviridae; Animals; Blotting, Northern; Blotting, Western; Cell Line; Choline; Cytochrome P-450 CYP2E1; DNA-Binding Proteins; Down-Regulation; Fatty Liver; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucose; Glutathione Peroxidase; Glycogen Synthase Kinase 3; Hepatitis; Hepatocytes; Humans; Immunoprecipitation; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Transcription Factors; Tyrosine; Up-Regulation | 2005 |
Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.
Topics: Animals; Cells, Cultured; Cytokines; DNA-Binding Proteins; Enzyme Activation; Fibroblasts; Genes, Reporter; Humans; Immunoblotting; Immunoprecipitation; Interferon Type I; Interferon-alpha; Interferon-beta; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Interferons; Luciferases; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Recombinant Proteins; Response Elements; Serine; Signal Transduction; Time Factors; Transcription Factors; Transcription, Genetic; Tyrosine; Ubiquitins | 2005 |
Identification of residues that contribute to receptor activation through the analysis of compensatory mutations in the G protein-coupled alpha-factor receptor.
Topics: Alanine; Amino Acid Sequence; Cysteine; DNA Mutational Analysis; Genes, Suppressor; Genetic Testing; Mating Factor; Molecular Sequence Data; Mutagenesis; Peptides; Phenylalanine; Receptors, G-Protein-Coupled; Receptors, Mating Factor; Receptors, Peptide; Saccharomyces cerevisiae Proteins; Serine; Signal Transduction; Threonine; Transcription Factors; Tyrosine | 2005 |
A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.
Topics: Actins; Active Transport, Cell Nucleus; Animals; cdc42 GTP-Binding Protein; Cell Movement; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclin D1; Cytoskeleton; DNA-Binding Proteins; DNA, Complementary; Fibroblasts; Gene Deletion; Genes, Reporter; Immunoblotting; Inflammation; Interleukin-6; Luciferases; Mice; Mice, Knockout; Microscopy, Fluorescence; Models, Biological; Mutation; Myosin Light Chains; NF-kappa B; Phosphorylation; Promoter Regions, Genetic; Protein Structure, Tertiary; rac1 GTP-Binding Protein; Retroviridae; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrosine; Wound Healing | 2005 |
The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2.
Topics: Animals; ATP-Binding Cassette Transporters; Dose-Response Relationship, Drug; Glyburide; Mice; Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Receptors, Drug; Serine; Sulfonylurea Receptors; Tyrosine | 2005 |
Extracorporeal shock waves: from lithotripsy to anti-inflammatory action by NO production.
Topics: Anti-Inflammatory Agents; Endothelium, Vascular; High-Energy Shock Waves; Humans; Interferon-gamma; Lipopolysaccharides; Lithotripsy; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Serine; Tyrosine | 2005 |
Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Synergism; Epilepsy; Focal Adhesion Kinase 2; Hippocampus; Lithium; Male; Muscarinic Agonists; Neurons; Phosphorylation; Pilocarpine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Serine; src-Family Kinases; Status Epilepticus; Tyrosine | 2005 |
Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.
Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Cell Cycle Proteins; Cell Growth Processes; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; Humans; Interleukin-6; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-myc; Quinolones; Serine; STAT3 Transcription Factor; Trans-Activators; Tyrosine; Up-Regulation | 2005 |
PDGF alpha-receptor signal strength controls an RTK rheostat that integrates phosphoinositol 3'-kinase and phospholipase Cgamma pathways during oligodendrocyte maturation.
Topics: Age Factors; Animals; Animals, Newborn; Antigens; Blotting, Western; Cell Count; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Gangliosides; Gene Transfer Techniques; Immunohistochemistry; In Vitro Techniques; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Biology; Mutagenesis; Myelin Basic Protein; O Antigens; Oligodendroglia; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Proteoglycans; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Serine; Signal Transduction; Spinal Cord; Stem Cells; Tyrosine | 2005 |
The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain.
Topics: Animals; Aorta; Cell Proliferation; Cells, Cultured; DNA-Binding Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Phosphorylation; Pyrazoles; Pyrimidines; Rats; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Stress, Mechanical; Trans-Activators; Tyrosine | 2005 |
Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Blotting, Western; Cell Count; Cell Death; Cells, Cultured; Drug Interactions; Embryo, Mammalian; Estradiol; Excitatory Amino Acid Agonists; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Phosphorylation; Pregnancy; Propidium; Rats; Rats, Sprague-Dawley; Serine; tau Proteins; Tetrazolium Salts; Thiazoles; Tyrosine | 2005 |
Novel missense mutations in two patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined factor XI and factor IX deficiency (Phe349Val).
Topics: Child; Codon; DNA Primers; Exons; Factor IX; Factor XI; Factor XI Deficiency; Female; Genotype; Hemophilia B; Hemorrhage; Humans; Introns; Leucine; Male; Mutation; Mutation, Missense; Phenotype; Phenylalanine; Polymerase Chain Reaction; Serine; Tyrosine; Valine | 2005 |
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.
Topics: Amino Acid Sequence; Animals; Biotin; Blood Platelets; Blotting, Western; Cell Communication; Cell Line; Cloning, Molecular; COS Cells; Cross-Linking Reagents; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Epidermal Growth Factor; Eptifibatide; Flow Cytometry; Humans; Immunoprecipitation; Mass Spectrometry; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Peptides; Peroxidase; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Signal Transduction; Threonine; Tissue Distribution; Transfection; Tyrosine | 2005 |
Molecular recognition by a binary code.
Topics: Amino Acid Sequence; Antibodies; Antibody Specificity; Antigens; Binding Sites, Antibody; Crystallography; Humans; Immunoglobulin Fab Fragments; Molecular Conformation; Molecular Sequence Data; Peptide Library; Protein Conformation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Serine; Tyrosine; Vascular Endothelial Growth Factor A | 2005 |
Roles of the disulfide bond and adjacent residues in determining the reduction potentials and stabilities of respiratory-type Rieske clusters.
Topics: Amino Acid Substitution; Animals; Cattle; Disulfides; Electrochemistry; Electron Transport Complex III; Enzyme Stability; Hydrogen Bonding; Hydrogen-Ion Concentration; Iron-Sulfur Proteins; Leucine; Models, Chemical; Mutagenesis, Site-Directed; Oxidation-Reduction; Serine; Structure-Activity Relationship; Thermodynamics; Tyrosine | 2005 |
Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase.
Topics: Active Transport, Cell Nucleus; Alternative Splicing; Androstadienes; Animals; beta Catenin; Blotting, Western; Cell Nucleus; Cyclin D1; Cytoplasm; Cytoskeletal Proteins; Enzyme Inhibitors; Gene Silencing; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Models, Biological; Neoplasms; NIH 3T3 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Receptor Protein-Tyrosine Kinases; RNA, Messenger; RNA, Small Interfering; Serine; Trans-Activators; Tyrosine; Wortmannin | 2005 |
Effects of Ser2 and Tyr6 mutants of BAF53 on cell growth and p53-dependent transcription.
Topics: Actins; Adaptor Proteins, Signal Transducing; Alanine; Cell Proliferation; Cells, Cultured; Chromatin; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Humans; Kidney; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Serine; Transcription Factors; Transcription, Genetic; Tumor Suppressor Protein p53; Tyrosine | 2005 |
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Topics: Animals; Aspartic Acid; Cell Line; Cell Membrane; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hippocampus; Humans; Immunoprecipitation; MAP Kinase Signaling System; Models, Biological; Mutation; Neurons; Phosphatidylethanolamine Binding Protein; Phosphorylation; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Rats; RNA; RNA, Small Interfering; Serine; Signal Transduction; Time Factors; Tyrosine | 2005 |
Base catalysis of chromophore formation in Arg96 and Glu222 variants of green fluorescent protein.
Topics: Amino Acid Sequence; Anions; Arginine; Carbon; Catalysis; Glutamic Acid; Glycine; Green Fluorescent Proteins; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrogen; Peptides; Protein Binding; Protons; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry; Temperature; Time Factors; Trypsin; Tyrosine; Ultraviolet Rays | 2005 |
Critical hydrophobic interactions between phosphorylation and actuator domains of Ca2+-ATPase for hydrolysis of phosphorylated intermediate.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alanine; Animals; Calcium; Calcium-Transporting ATPases; Catalytic Domain; Crystallography, X-Ray; Hydrolysis; Isoleucine; Kinetics; Leucine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Phosphorylation; Potassium; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine; Temperature; Time Factors; Tyrosine | 2005 |
Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
Topics: Amino Acid Sequence; Glycopeptides; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2005 |
ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Blood Vessels; Cell Membrane; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Hypertension; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monosaccharide Transport Proteins; Muscle Proteins; Myocytes, Smooth Muscle; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Tyrosine | 2005 |
PKCdelta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells.
Topics: Anisomycin; Breast Neoplasms; Enzyme Activation; Female; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Oligonucleotides, Antisense; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinases; Protein Synthesis Inhibitors; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tyrosine | 2005 |
Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs.
Topics: Animals; Cell Line; Drosophila Proteins; Dyrk Kinases; Insecta; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Tyrosine | 2005 |
Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Nucleus; Cytochrome P450 Family 2; DNA-Binding Proteins; Growth Hormone; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Liver; Male; Milk Proteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Wistar; Serine; Signal Transduction; STAT5 Transcription Factor; Steroid 16-alpha-Hydroxylase; Testosterone; Trans-Activators; Tyrosine; Vitamin A; Vitamin A Deficiency | 2005 |
Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Epoprostenol; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Proteins; Humans; Leukemia, Erythroblastic, Acute; MAP Kinase Kinase 1; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Pertussis Toxin; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Epoprostenol; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Time Factors; Transcription, Genetic; Tyrosine | 2006 |
The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
Topics: Animals; beta-Adrenergic Receptor Kinases; Cattle; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Feedback, Physiological; G-Protein-Coupled Receptor Kinase 5; GTP-Binding Proteins; Humans; Models, Biological; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Adrenergic, beta-2; Serine; Signal Transduction; src-Family Kinases; Tyrosine | 2005 |
Mutation of the adenylylated tyrosine of glutamine synthetase alters its catalytic properties.
Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Alanine; Catalysis; Cations, Divalent; Enzyme Activation; Escherichia coli Proteins; Esterification; Feedback, Physiological; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Glutamine; Hydrogen-Ion Concentration; Hydroxides; Magnesium; Manganese; Mutagenesis, Site-Directed; Phenylalanine; Serine; Tyrosine | 2005 |
Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes.
Topics: Animals; Calcium; Cations; Cell Membrane; Chloride Channels; Chlorides; Cytoplasm; Membrane Proteins; Mutation; Oocytes; Patch-Clamp Techniques; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Protein Structure, Tertiary; Proteins; Radioisotopes; RNA, Complementary; Serine; TRPP Cation Channels; Tyrosine; Xenopus | 2005 |
Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Breast Neoplasms; Calorimetry; Cell Cycle Proteins; Crystallography, X-Ray; DNA Damage; DNA-Binding Proteins; Escherichia coli; Glutamic Acid; Glutamine; Glutathione Transferase; Histones; Humans; Models, Molecular; Models, Statistical; Molecular Sequence Data; Nuclear Proteins; Peptides; Phosphates; Phosphopeptides; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Trans-Activators; Tyrosine | 2005 |
Resolving integral questions in site-specific recombination.
Topics: DNA; DNA-Binding Proteins; Models, Molecular; Recombinases; Recombination, Genetic; Serine; Tyrosine | 2005 |
CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.
Topics: Aurora Kinase A; Aurora Kinases; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Nucleus; Centrosome; Cyclin B; Cyclin B1; DNA Damage; G2 Phase; HeLa Cells; Histones; Humans; Microscopy, Fluorescence; Mitosis; Mutation; Phosphorylation; Protein Conformation; Protein Serine-Threonine Kinases; Serine; Time Factors; Transfection; Tyrosine | 2005 |
Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages.
Topics: Animals; Antioxidants; Cell Line; Cell Survival; Cinnamates; Depsides; Dose-Response Relationship, Drug; I-kappa B Proteins; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Phosphorylation; Reactive Nitrogen Species; Reactive Oxygen Species; Rosmarinic Acid; Serine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2005 |
Four novel connexin 32 mutations in X-linked Charcot-Marie-Tooth disease with phenotypic variability.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Charcot-Marie-Tooth Disease; Chromosomes, Human, X; Codon, Terminator; Connexins; DNA Mutational Analysis; Family Health; Female; Gap Junction beta-1 Protein; Humans; Leucine; Male; Middle Aged; Mutation; Phenotype; Phenylalanine; Proline; Serine; Tyrosine; Valine | 2006 |
Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation.
Topics: Acrosome Reaction; Culture Media; Cyclic AMP-Dependent Protein Kinases; Dimethyl Sulfoxide; Enzyme Activation; Fertilization in Vitro; Humans; Male; Phosphorylation; Progesterone; Serine; Sperm Capacitation; Spermatozoa; Threonine; Tyrosine | 2005 |
Characterization of STAT5B phosphorylation correlating with expression of cytokine-inducible SH2-containing protein (CIS).
Topics: Animals; Cell Line; Cell Nucleus; Cells, Cultured; Electrophoretic Mobility Shift Assay; Immediate-Early Proteins; Interleukin-3; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Models, Molecular; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Serine; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes; Tyrosine; Vanadates | 2006 |
Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.
Topics: Atherosclerosis; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Humans; Inflammation; Models, Biological; Mutation; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Structure, Tertiary; Receptor, PAR-1; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; src-Family Kinases; Threonine; Thrombin; Thrombomodulin; Time Factors; Tyrosine; Umbilical Veins | 2005 |
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Middle Aged; Okadaic Acid; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Time Factors; Tyrosine | 2005 |
Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-1; Interleukin-6; Mice; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Tyrosine | 2006 |
Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells.
Topics: Anaerobiosis; Animals; Breast Neoplasms; Cell Hypoxia; Chlorocebus aethiops; COS Cells; Cyclin D1; Deferoxamine; Female; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 2; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Serine; Tumor Cells, Cultured; Tyrosine | 2005 |
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.
Topics: Agar; Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Gene Deletion; Insulin Receptor Substrate Proteins; Mice; Mutation; Neurons; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pol1 Transcription Initiation Complex Proteins; Receptor, IGF Type 1; Ribosomes; RNA; RNA, Ribosomal; Serine; Signal Transduction; Time Factors; Transfection; Tyrosine | 2006 |
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroquinones; Iliac Artery; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Phenylephrine; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinoxalines; Serine; Signal Transduction; Swine; Triazoles; Tyrosine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB, and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages.
Topics: Animals; Blotting, Western; Cell Line; Cell Nucleus; Escherichia coli; I-kappa B Proteins; Immunoprecipitation; Lipopolysaccharides; Macrophages, Peritoneal; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Serine; src-Family Kinases; Stimulation, Chemical; Tyrosine | 2005 |
Nuclear export determines the cytokine sensitivity of STAT transcription factors.
Topics: Active Transport, Cell Nucleus; Alternative Splicing; Blotting, Western; Cell Nucleus; Cytokines; Cytoplasm; Dimerization; Dose-Response Relationship, Drug; Genes, Reporter; Glutathione Transferase; Green Fluorescent Proteins; HeLa Cells; Humans; Microscopy, Confocal; Models, Biological; Peptides; Phosphorylation; Plasmids; Protein Structure, Tertiary; Recombinant Proteins; Serine; src Homology Domains; STAT Transcription Factors; STAT1 Transcription Factor; Time Factors; Transcription, Genetic; Transcriptional Activation; Tyrosine | 2005 |
Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Chi-Square Distribution; Cytochrome P-450 CYP2D6; Depression; Female; Fluvoxamine; Humans; Japan; Male; Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Proline; Receptor, Serotonin, 5-HT2A; Serine; Tyrosine | 2006 |
Functional plasticity in the substrate binding site of beta-secretase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Asparagine; Aspartic Acid Endopeptidases; Binding Sites; Catalysis; Computer Simulation; Crystallography, X-Ray; Endopeptidases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Oligopeptides; Protein Conformation; Protein Structure, Secondary; Protons; Serine; Substrate Specificity; Temperature; Tyrosine; Water | 2005 |
Substrate specificity and activity regulation of protein kinase MELK.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Binding Sites; Buffers; Calcium; Cell Cycle; Cell Line; Chlorocebus aethiops; COS Cells; Dithiothreitol; Enzyme Activation; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glutathione; Humans; Ions; Kinetics; Ligands; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Peptides; Phosphorylation; Protein Array Analysis; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; Serine; Stem Cells; Substrate Specificity; Threonine; Tyrosine | 2005 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
Topics: Active Transport, Cell Nucleus; Animals; Anisomycin; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Etoposide; Fibroblasts; Genes, Dominant; Humans; Hypoxia; Imidazoles; Immunoprecipitation; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Oxidoreductases; Phosphorylation; Piperazines; Proteasome Endopeptidase Complex; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; U937 Cells; Ultraviolet Rays; WW Domain-Containing Oxidoreductase | 2005 |
Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Janus Kinase 3; Mice; Mutation; Oncogenes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; Serine; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Tyrosine | 2006 |
Paxillin phosphorylation sites mapped by mass spectrometry.
Topics: Animals; Cell Line; Chickens; Chromatography, High Pressure Liquid; Humans; Mice; Paxillin; Phosphorylation; Serine; Spectrometry, Mass, Electrospray Ionization; Threonine; Transfection; Tyrosine | 2005 |
FAK phosphorylation sites mapped by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Cell Line; Chickens; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mass Spectrometry; Molecular Sequence Data; Phosphopeptides; Serine; Spectrometry, Mass, Electrospray Ionization; Threonine; Tyrosine | 2005 |
Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Rats; Serine; Substrate Specificity; Tyrosine; Wiskott-Aldrich Syndrome Protein | 2005 |
Thermodynamic functions and intra-particle mass transfer kinetics of structural analogues of a template on molecularly imprinted polymers in liquid chromatography.
Topics: Adsorption; Algorithms; Chromatography, Liquid; Fluorenes; Glycine; Kinetics; Models, Chemical; Particle Size; Phenylalanine; Polymers; Serine; Stereoisomerism; Temperature; Thermodynamics; Tryptophan; Tyrosine | 2005 |
Identification of constitutive phosphorylation sites on the Epstein-Barr virus ZEBRA protein.
Topics: Binding Sites; Biochemistry; Cell Line, Tumor; Cell Movement; Cysteine; DNA-Binding Proteins; Escherichia coli; Genetic Vectors; Herpesvirus 4, Human; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methionine; Mutagenesis; Peptides; Phosphorylation; Protein Structure, Tertiary; Serine; Threonine; Trans-Activators; Transfection; Trypsin; Tyrosine; Viral Proteins | 2006 |
Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I.
Topics: Blotting, Western; Cell Line; Cell Transformation, Viral; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Human T-lymphotropic virus 1; Humans; Immunoprecipitation; Interferon-gamma; Janus Kinase 2; Jurkat Cells; Membrane Proteins; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Serine; STAT3 Transcription Factor; STAT4 Transcription Factor; T-Lymphocytes; Transcription, Genetic; Transcriptional Activation; Transfection; TYK2 Kinase; Tyrosine | 2005 |
Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells.
Topics: Adenocarcinoma; Alkaline Phosphatase; Androstadienes; beta Catenin; Butyrates; Cell Line, Tumor; Colorectal Neoplasms; Humans; Immunohistochemistry; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Tyrosine; Wortmannin | 2006 |
Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin.
Topics: Alkaline Phosphatase; Blotting, Western; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; HT29 Cells; Humans; Immunoprecipitation; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphorylation; Serine; Signal Transduction; Threonine; Tyrosine | 2006 |
Effect of five triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of p47(phox), p67(phox), and rac to cell membrane in human neutrophils.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Cells, Cultured; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; rac GTP-Binding Proteins; Serine; Superoxides; Tetradecanoylphorbol Acetate; Threonine; Triterpenes; Tyrosine | 2006 |
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.
Topics: Animals; Blotting, Western; Cell Line; Deoxyglucose; Glucose; Humans; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Interleukin-6; Liver; Mice; Mice, Inbred C57BL; Models, Statistical; Muscle, Skeletal; Muscles; Phosphoproteins; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Serine; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Time Factors; Transfection; Tyrosine | 2006 |
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Animals; Binding Sites; CD11b Antigen; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Myeloid; Mice; Mice, Knockout; Mutation; Phosphorylation; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Serine; Signal Transduction; Tyrosine | 2006 |
UCHL-1 is not a Parkinson's disease susceptibility gene.
Topics: Case-Control Studies; Confidence Intervals; Female; Genotype; Humans; Linkage Disequilibrium; Male; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Parkinson Disease; Polymorphism, Genetic; Serine; Tyrosine; Ubiquitin Thiolesterase | 2006 |
The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Humans; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pioglitazone; PPAR gamma; Serine; Signal Transduction; Thiazolidinediones; Threonine; Transfection; Tyrosine | 2006 |
Phosphate group-driven fragmentation of multiply charged phosphopeptide anions. Improved recognition of peptides phosphorylated at serine, threonine, or tyrosine by negative ion electrospray tandem mass spectrometry.
Topics: Amino Acid Sequence; Anions; Phosphates; Phosphopeptides; Phosphorylation; Serine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Threonine; Tyrosine | 2006 |
Regulation of sprouty stability by Mnk1-dependent phosphorylation.
Topics: Animals; Cell Proliferation; Cells, Cultured; Electrophoretic Mobility Shift Assay; Fibroblast Growth Factors; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins c-cbl; Serine; Tyrosine | 2006 |
Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides.
Topics: Dengue Virus; Escherichia coli; Fluorescence; ortho-Aminobenzoates; Peptide Library; RNA Helicases; Serine; Serine Endopeptidases; Substrate Specificity; Tyrosine; Viral Nonstructural Proteins | 2006 |
Analysis of the dynamic Bacillus subtilis Ser/Thr/Tyr phosphoproteome implicated in a wide variety of cellular processes.
Topics: Bacillus subtilis; Bacterial Proteins; Cold Temperature; Culture Media; Electrophoresis, Gel, Two-Dimensional; Hot Temperature; Mass Spectrometry; Osmotic Pressure; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Proteomics; Serine; Threonine; Tyrosine | 2006 |
Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions.
Topics: Adult; Age Factors; Aged; Aging; Apoptosis; Chemotaxis, Leukocyte; Down-Regulation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunity, Cellular; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Neutrophils; Phosphorylation; Protein Phosphatase 1; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Serine; src-Family Kinases; Tyrosine | 2006 |
The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution.
Topics: Acylation; Bacterial Proteins; beta-Lactamases; Binding Sites; Boronic Acids; Catalysis; Crystallography, X-Ray; Hydrogen Bonding; Lysine; Models, Molecular; Protein Conformation; Serine; Structure-Activity Relationship; Tyrosine | 2006 |
Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism.
Topics: Alanine; Alzheimer Disease; Animals; Brain; Cattle; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mutation; Phosphorylation; Serine; tau Proteins; Transfection; Tyrosine | 2006 |
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis.
Topics: Crystallography, X-Ray; Glycine; Green Fluorescent Proteins; Kinetics; Models, Molecular; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Serine; Tyrosine | 2006 |
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement.
Topics: Animals; Cell Movement; Cytoskeleton; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Glycogen Synthase Kinase 3; Humans; Lipopolysaccharides; Macrophages; Mice; Nerve Growth Factors; Neurites; Paxillin; PC12 Cells; Phosphorylation; Protein Transport; Rats; Serine; Tyrosine | 2006 |
Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic sinusoidal endothelial cells in vitro and in vivo.
Topics: 14-3-3 Proteins; Animals; Apoptosis; bcl-Associated Death Protein; Caspase 3; Caspase 9; Caspases; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Liver; Male; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Inbred F344; Rats, Wistar; Reperfusion Injury; Serine; Signal Transduction; Tyrosine; Vanadates | 2006 |
Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons.
Topics: Animals; Calcium; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tyrosine | 2006 |
A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor.
Topics: Amino Acid Sequence; Animals; Bone Marrow; Female; Humans; Kidney; Ligands; Macrophage Colony-Stimulating Factor; Macrophages; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins pp60(c-src); Receptor, Macrophage Colony-Stimulating Factor; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Serine; Signal Transduction; Tyrosine | 2006 |
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Case-Control Studies; Chi-Square Distribution; China; DNA Mutational Analysis; Female; Gene Frequency; Genetics, Population; Humans; Male; Middle Aged; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sex Factors; Tyrosine; Ubiquitin Thiolesterase | 2006 |
[Subunits of human holoenzyme of DNA dependent RNA polymerase III phosphorylated in vivo].
Topics: Carcinoma, Squamous Cell; Catalytic Domain; Cell Line, Tumor; Cell Nucleus; Chromatography, DEAE-Cellulose; Holoenzymes; Humans; Immunoblotting; Molecular Weight; Phosphorylation; Placenta; RNA Polymerase III; Serine; Threonine; Tyrosine | 2005 |
Effect of Agkistroden blomhoffi (mamushi) on superoxide generation in human neutrophils.
Topics: Agkistrodon; Animals; Cytochromes c; Electrophoresis, Polyacrylamide Gel; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Protein Transport; rac GTP-Binding Proteins; Serine; Superoxides; Threonine; Tyrosine | 2006 |
Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Models, Molecular; Mutagenesis, Site-Directed; Propanolamines; Rats; Receptors, Adrenergic, beta-1; Serine; Stereoisomerism; Transfection; Tyrosine | 2006 |
Trends in antibody sequence changes during the somatic hypermutation process.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites, Antibody; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, B-Lymphocyte, Light Chain; Germ-Line Mutation; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Immunoglobulin Variable Region; Molecular Sequence Data; Probability; Protein Structure, Tertiary; Serine; Somatic Hypermutation, Immunoglobulin; Tryptophan; Tyrosine | 2006 |
Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa.
Topics: Animals; CSK Tyrosine-Protein Kinase; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Gel, Two-Dimensional; Female; Indoles; Male; Mass Spectrometry; Mice; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Serine; Sperm Capacitation; Spermatozoa; src-Family Kinases; Sulfonamides; Tyrosine | 2006 |
Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Cysteine; Female; Glutamic Acid; Glycine; Humans; Leucine; Male; Middle Aged; Multivariate Analysis; Mutation; Phenylalanine; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Receptor, Fibroblast Growth Factor, Type 3; Sequence Analysis, DNA; Serine; Tyrosine; Urinary Bladder Neoplasms | 2006 |
Interaction of vanadyl (VO2+) with ligands containing serine, tyrosine, and threonine.
Topics: Crystallography, X-Ray; Ligands; Models, Molecular; Molecular Conformation; Organometallic Compounds; Schiff Bases; Serine; Threonine; Tyrosine; Vanadates | 2006 |
A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA.
Topics: Animals; Animals, Newborn; Axons; Blotting, Western; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunohistochemistry; Indole Alkaloids; Indoles; Nerve Growth Factor; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkA; Serine; Signal Transduction; Superior Cervical Ganglion; Tyrosine | 2007 |
Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3.
Topics: Active Transport, Cell Nucleus; Arachidonate 15-Lipoxygenase; Cells, Cultured; Cytosol; Gene Expression Regulation; Humans; Monocytes; Phosphorylation; Protein Kinase C-delta; Recombinant Proteins; Serine; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Tyrosine | 2006 |
Epstein-Barr virus latent membrane protein 1 mediates phosphorylation and nuclear translocation of annexin A2 by activating PKC pathway.
Topics: Active Transport, Cell Nucleus; Annexin A2; Cell Line, Tumor; Cell Nucleus; Energy Metabolism; Humans; Phosphorylation; Protein Kinase C; Serine; Signal Transduction; Temperature; Tyrosine; Viral Matrix Proteins | 2007 |
Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Biomarkers; Brain; Cytoplasmic Granules; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Humans; Immunohistochemistry; MAP Kinase Kinase 1; MAP Kinase Signaling System; Neurofibrillary Tangles; Phosphorylation; Proto-Oncogene Proteins c-raf; Pyramidal Cells; ras Proteins; Serine; Signal Transduction; Tyrosine; Up-Regulation | 2006 |
Overexpression of phosphorylated STAT-1alpha in the labial salivary glands of patients with Sjögren's syndrome.
Topics: Gene Expression; Genetic Predisposition to Disease; Humans; Interferon-Stimulated Gene Factor 3; Phosphorylation; RNA, Messenger; Salivary Ducts; Salivary Glands, Minor; Serine; Sjogren's Syndrome; STAT1 Transcription Factor; STAT2 Transcription Factor; Tyrosine | 2006 |
Effect of L-serine on the biosynthesis of aromatic amino acids in Escherichia coli.
Topics: Amino Acids; Amino Acids, Aromatic; Caseins; Culture Media; Enzyme Inhibitors; Escherichia coli; Phenylalanine; Prephenate Dehydratase; Reverse Transcriptase Polymerase Chain Reaction; Serine; Tryptophan; Tyrosine | 2006 |
Ecto- and exo-protein kinases in Schistosoma mansoni: regulation of surface phosphorylation by acetylcholine and identification of the alpha subunit of CKII as a major secreted protein kinase.
Topics: Acetylcholine; Animals; Biomphalaria; Casein Kinase II; Caseins; Electrophoresis, Polyacrylamide Gel; Heparin; Mice; Phosphorylation; Phosvitin; Protein Kinase Inhibitors; Protein Kinases; Schistosoma mansoni; Serine; Threonine; Tyrosine | 2005 |
FAK phosphorylation at Ser-843 inhibits Tyr-397 phosphorylation, cell spreading and migration.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Movement; Cell Shape; Cytochalasin D; Cytoskeleton; Epithelial Cells; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice; Mice, Knockout; Mutation; Phosphorylation; Rats; Serine; Tyrosine | 2007 |
Hydroxyl groups in the betabeta sandwich of metallo-beta-lactamases favor enzyme activity: Tyr218 and Ser262 pull down the lid.
Topics: beta-Lactamases; Catalysis; Computer Simulation; Enzyme Activation; Hydrogen Bonding; Hydroxides; Metals; Models, Molecular; Molecular Structure; Mutation; Protein Structure, Tertiary; Serine; Structure-Activity Relationship; Tyrosine; Zinc | 2007 |
Survival response-linked Pyk2 activation during potassium depletion-induced apoptosis of cerebellar granule neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Caspases; Cell Survival; Cerebellum; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Activation; Focal Adhesion Kinase 2; Mice; Mutagenesis; Neurons; Potassium; Potassium Chloride; Serine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tyrosine | 2007 |
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Binding Sites; Chromatography, Liquid; DNA-Binding Proteins; Genes, Bacterial; Mass Spectrometry; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Proteome; Proteomics; Repressor Proteins; Serine; Threonine; Tyrosine | 2007 |
Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters.
Topics: Amino Acid Substitution; Bacterial Proteins; Crystallography, X-Ray; Electron Transport Complex III; Hydrogen Bonding; Iron-Sulfur Proteins; Mutation; Oxidation-Reduction; Protein Conformation; Rhodobacter sphaeroides; Serine; Structure-Activity Relationship; Tyrosine | 2007 |
Long range behavior of high-rank topological multipole moments.
Topics: Carbon Monoxide; Computational Biology; Models, Chemical; Models, Molecular; Molecular Conformation; Serine; Tuftsin; Tyrosine; Water | 2007 |
Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis.
Topics: Amino Acid Sequence; Bacterial Proteins; Cloning, Molecular; Escherichia coli; Lysine; Molecular Sequence Data; Oxygen; Peptide Synthases; Pigmentation; Plasmids; Protein Binding; Protein Structure, Tertiary; Serine; Streptomyces; Transferases (Other Substituted Phosphate Groups); Tyrosine | 2007 |
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.
Topics: Angiotensins; Animals; Carbachol; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intestinal Mucosa; Ionomycin; Kinetics; Lysophospholipids; Phosphorylation; Protein Kinase C; Rats; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Tyrosine | 2007 |
FOXL2 mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome.
Topics: Asian People; Blepharophimosis; Blepharoptosis; Cysteine; Cytosine; Eye Abnormalities; Eyelids; Forkhead Box Protein L2; Forkhead Transcription Factors; Guanine; Heterozygote; Histidine; Humans; Mutation; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Serine; Syndrome; Thymine; Tyrosine | 2007 |
The effects of hydrogen-bonding environment on the polarization and electronic properties of water molecules.
Topics: Electrons; Hydrogen Bonding; Models, Chemical; Serine; Tyrosine; Water | 2007 |
AT1 receptor blocker-insensitive mutant AT1A angiotensin receptors reveal the presence of G protein-independent signaling in C9 cells.
Topics: Amino Acid Substitution; Angiotensin II Type 1 Receptor Blockers; Animals; Arrestins; Benzimidazoles; beta-Arrestins; Biphenyl Compounds; Cells, Cultured; Chlorocebus aethiops; COS Cells; Epithelial Cells; GTP-Binding Proteins; Muscles; Mutation; Rats; Receptor, Angiotensin, Type 1; Serine; Signal Transduction; Tetrazoles; Tyrosine | 2007 |
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.
Topics: DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Mutation; Odds Ratio; Parkinson Disease; Serine; Sweden; Tyrosine; Ubiquitin Thiolesterase | 2007 |
[Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats].
Topics: Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Serine; Tyrosine | 2006 |
Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance.
Topics: Adult; Asparagine; Charcot-Marie-Tooth Disease; Child; Consanguinity; Demyelinating Diseases; DNA Mutational Analysis; Female; Genes, Recessive; Humans; Microscopy, Electron, Transmission; Mutation; Myelin P0 Protein; Myelin Sheath; Peripheral Nerves; Phenylalanine; Serine; Tyrosine | 2007 |
Enhancement of the efficiency of phosphoproteomic identification by removing phosphates after phosphopeptide enrichment.
Topics: Alkaline Phosphatase; Animals; Cell Line, Tumor; Cells, Cultured; Mice; Neuroblastoma; Phosphates; Phosphopeptides; Phosphoproteins; Phosphorylation; Prosencephalon; Proteomics; Serine; Trypsin; Tyrosine | 2007 |
Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins.
Topics: Animals; Escherichia coli; Esters; Fireflies; Glycosylation; Models, Molecular; Nucleic Acid Conformation; Protein Structure, Tertiary; Proteins; RNA, Transfer; Serine; Tetrahydrofolate Dehydrogenase; Tyrosine | 2007 |
LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; DNA Mutational Analysis; Europe; Exons; Female; Histidine; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinson Disease; Protein Serine-Threonine Kinases; Serine; Threonine; Tyrosine | 2007 |
Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of tyrosine and serine phosphorylation.
Topics: Oligopeptides; Phosphorylation; Sensitivity and Specificity; Serine; Spectrum Analysis, Raman; Tyrosine | 2007 |
The proton pumping pathway of bovine heart cytochrome c oxidase.
Topics: Animals; Aspartic Acid; Cattle; Electron Transport Complex IV; HeLa Cells; Humans; Models, Biological; Models, Chemical; Mutagenesis; Myocardium; Oxygen; Peptides; Protons; Serine; Tyrosine | 2007 |
[Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn].
Topics: Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Burns; Dimethyl Sulfoxide; Disease Models, Animal; Female; Glucose Clamp Technique; Immunohistochemistry; Injections, Intravenous; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Muscles; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Serine; Tyrosine | 2007 |
Myocilin mutations among primary open angle glaucoma patients of Kanyakumari district, South India.
Topics: Aged; Asian People; Base Sequence; Cytoskeletal Proteins; Eye Proteins; Female; Glaucoma, Open-Angle; Glycoproteins; Humans; India; Leucine; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Proline; Serine; Threonine; Tyrosine | 2007 |
Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Enzyme Activation; Humans; Mice; Patch-Clamp Techniques; Phosphorylation; Protein Subunits; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Fusion Proteins; Serine; Tyrosine | 2007 |
Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells.
Topics: Antigen-Presenting Cells; Apoptosis; Cells, Cultured; Coculture Techniques; Dendritic Cells; Genetic Vectors; Hepatitis C; Hepatitis C Antigens; Humans; Immunophenotyping; Interferon-alpha; Interleukin-8; Monocytes; Oligonucleotide Array Sequence Analysis; Phagocytosis; Phosphorylation; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; STAT1 Transcription Factor; STAT2 Transcription Factor; Tyrosine; Vaccinia virus | 2007 |
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Cytokines; Gene Expression Regulation, Neoplastic; Humans; Male; NF-kappa B; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Serine; Signal Transduction; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes.
Topics: Acetylation; B-Lymphocytes; Base Sequence; Cell Line; DNA; Genes, Viral; Herpesvirus 4, Human; Humans; Interferon Type I; Lysine; Macromolecular Substances; MAP Kinase Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Recombinant Proteins; Serine; STAT1 Transcription Factor; Tyrosine; Viral Matrix Proteins | 2007 |
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Death; Cell Line; Chlorocebus aethiops; Extracellular Signal-Regulated MAP Kinases; Humans; Mice; Mitogen-Activated Protein Kinase 8; Mutagenesis, Site-Directed; NF-kappa B; Oxidoreductases; Recombinant Fusion Proteins; Serine; Signal Transduction; TNF Receptor-Associated Death Domain Protein; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; Ultraviolet Rays; WW Domain-Containing Oxidoreductase | 2007 |
Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity.
Topics: Animals; Blotting, Western; Cell Line; Cell Membrane; Cell Nucleus; Green Fluorescent Proteins; Humans; Immunoprecipitation; Jurkat Cells; Membrane Microdomains; Mice; Mutation; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Receptors, Antigen, T-Cell; Serine; Signal Transduction; Tyrosine | 2007 |
Reciprocal phosphorylation and glycosylation recognition motifs control NCAPP1 interaction with pumpkin phloem proteins and their cell-to-cell movement.
Topics: Amino Acid Motifs; Amino Acid Sequence; Biological Transport; Cucurbita; Glycosylation; Immunoprecipitation; Molecular Sequence Data; Mutation; Nicotiana; Peptides; Phloem; Phosphorylation; Plant Proteins; Plasmodesmata; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Recombinant Proteins; Serine; Tyrosine | 2007 |
Identification of histidine phosphorylations in proteins using mass spectrometry and affinity-based techniques.
Topics: Bacterial Proteins; Biochemistry; Histidine; Histidine Kinase; Mass Spectrometry; Models, Chemical; Phosphorylation; Protein Kinases; Serine; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Tyrosine | 2007 |
[Epstein-Barr virus-encoded latent membrane protein 1 mediates serine-phosphorylation of annexin I by activating protein kinase C].
Topics: Annexin A1; Cell Line, Tumor; Humans; Nasopharyngeal Neoplasms; Phosphorylation; Protein Kinase C; Serine; Signal Transduction; Tyrosine; Viral Matrix Proteins | 2007 |
Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Inhibitory Concentration 50; Ovarian Neoplasms; Phosphorylation; Serine; Transfection; Tumor Suppressor Protein p53; Tyrosine | 2007 |
Combinations of two amino acids (Ala40 and Phe75 or Ser40 and Tyr75) in the coat protein of apple chlorotic leaf spot virus are crucial for infectivity.
Topics: Alanine; Amino Acid Sequence; DNA Primers; Flexiviridae; Malus; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Plant Diseases; Plant Leaves; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Serine; Tyrosine; Virus Replication | 2007 |
Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.
Topics: Amino Acid Substitution; Asparagine; Bacterial Proteins; Binding Sites; Cadherins; Calorimetry; Genetic Engineering; Genetic Variation; Glycine; Humans; Kinetics; Listeria monocytogenes; Models, Molecular; Protein Binding; Protein Conformation; Recombinant Proteins; Serine; Thermodynamics; Tyrosine | 2007 |
Dynamics of protein phosphorylation on Ser/Thr/Tyr in Bacillus subtilis.
Topics: Bacillus subtilis; Bacterial Proteins; Electrophoresis, Gel, Two-Dimensional; Isoelectric Focusing; Phosphorus Radioisotopes; Phosphorylation; Proteins; Serine; Staining and Labeling; Threonine; Tyrosine | 2007 |
STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
Topics: Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Butadienes; Capillaries; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Drug Synergism; Embryonic Stem Cells; Enzyme Inhibitors; Leukemia Inhibitory Factor; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocytes, Cardiac; Nitriles; Phosphorylation; Serine; Signal Transduction; STAT3 Transcription Factor; Stem Cell Transplantation; Transforming Growth Factor beta; Triterpenes; Tyrosine | 2007 |
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblasts; Humans; Membrane Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Serine; Tamoxifen; Tyrosine; Ubiquitin; Vanadates | 2007 |
Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation.
Topics: Amino Acid Sequence; Amino Acids; Bacillus subtilis; Bacterial Proteins; Conserved Sequence; Escherichia coli; Evolution, Molecular; Mass Spectrometry; Molecular Sequence Data; Phosphopeptides; Phosphoproteins; Phosphorylation; Proteome; Serine; Threonine; Tyrosine | 2008 |
Degradation of serine-containing oligopeptides by Peptostreptococcus micros ATCC 33270.
Topics: Acetate Kinase; Acetates; Acetyltransferases; Adenosine Triphosphate; Ammonia; Formate Dehydrogenases; Formates; Humans; L-Serine Dehydratase; Oligopeptides; Peptostreptococcus; Phosphate Acetyltransferase; Pyruvate Synthase; Pyruvic Acid; Serine; Tyrosine | 2007 |
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.
Topics: Animals; Drug Combinations; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Female; Glucose; Glucose Clamp Technique; Glycerol; I-kappa B Kinase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Serine; Signal Transduction; Sodium Salicylate; Time Factors; Tyrosine | 2007 |
Assessment of solvent residues accessibility using three Sulfo-NHS-biotin reagents in parallel: application to footprint changes of a methyltransferase upon binding its substrate.
Topics: Amino Acid Sequence; Amino Acids; Archaeal Proteins; Biotin; Lysine; Models, Molecular; Peptides; Protein Footprinting; Pyrococcus abyssi; RNA, Transfer; Serine; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Succinimides; tRNA Methyltransferases; Trypsin; Tyrosine | 2008 |
Determination of enantiomeric compositions of analytes using novel fluorescent chiral molecular micelles and steady state fluorescence measurements.
Topics: Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Glucose; Micelles; Molecular Structure; Phenylalanine; Serine; Spectrometry, Fluorescence; Stereoisomerism; Surface-Active Agents; Tartrates; Tryptophan; Tyrosine | 2008 |
Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.
Topics: Amino Acid Motifs; Asparagine; Biochemistry; Carbon-Carbon Lyases; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Fusarium; Glutamic Acid; Kinetics; Magnesium; Models, Chemical; Mutagenesis, Site-Directed; Serine; Tyrosine | 2008 |
Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation.
Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; eIF-2 Kinase; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Humans; Immunoblotting; Immunoprecipitation; Mice; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Plasmids; Protein Biosynthesis; Serine; Tyrosine | 2008 |
Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Odds Ratio; Parkinson Disease; Polymorphism, Genetic; Serine; Tyrosine; Ubiquitin Thiolesterase | 2008 |
Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.
Topics: Amino Acid Motifs; Amino Acid Substitution; Binding Sites; DNA; DNA Topoisomerases, Type I; Escherichia coli; Glycine; Magnesium; Methionine; Mutation; Phenotype; Serine; SOS Response, Genetics; Tyrosine; Valine; Yersinia pestis | 2008 |
Vibrational signatures of protonated, phosphorylated amino acids in the gas phase.
Topics: Gases; Models, Chemical; Molecular Structure; Phosphorylation; Protons; Serine; Spectrophotometry, Infrared; Threonine; Tyrosine; Vibration | 2008 |
Posttranslational modifications on protein kinase c isozymes. Effects of epinephrine and phorbol esters.
Topics: Acetylglucosamine; Animals; Enzyme Activation; Epinephrine; Hepatocytes; Isoenzymes; Male; Mass Spectrometry; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Wistar; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2008 |
Inhibitory effects of ginsenosides from the root of Panax ginseng on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation, and translocation of cytosolic compounds to plasma membrane in human neutrophils.
Topics: Cell Membrane; Cytochromes c; Cytosol; Ginsenosides; Neutrophils; Oxidation-Reduction; Panax; Phosphorylation; Plant Roots; Serine; Superoxides; Threonine; Tyrosine | 2008 |
Immunohistochemical localization of a GnRH-like peptide in the brain of the cephalopod spear-squid, Loligo bleekeri.
Topics: Animals; Antibodies, Monoclonal; Axons; Brain; Brain Chemistry; Chickens; Fluorescent Antibody Technique; Gonadotropin-Releasing Hormone; Immunohistochemistry; Loligo; Mice; Salmonidae; Serine; Species Specificity; Tyrosine | 2008 |
The intrinsic contributions of tyrosine, serine, glycine and arginine to the affinity and specificity of antibodies.
Topics: Amino Acid Sequence; Antibodies; Antibody Affinity; Antibody Specificity; Arginine; Binding Sites, Antibody; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycine; Models, Molecular; Peptide Library; Protein Binding; Serine; Tyrosine | 2008 |
Contributions of conserved serine and tyrosine residues to catalysis, ligand binding, and cofactor processing in the active site of tyrosine ammonia lyase.
Topics: Ammonia-Lyases; Bacterial Proteins; Catalysis; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Rhodobacter sphaeroides; Serine; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2008 |
Charge environments around phosphorylation sites in proteins.
Topics: Binding Sites; Databases, Protein; Models, Molecular; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Proteins; Serine; Threonine; Tyrosine | 2008 |
Ethanol inhibition of angiotensin II-stimulated Tyr705 and Ser727 STAT3 phosphorylation in cultured rat hepatocytes: relevance to activation of p42/44 mitogen-activated protein kinase.
Topics: Angiotensin II; Animals; Butadienes; Cells, Cultured; Enzyme Activation; Ethanol; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Serine; STAT3 Transcription Factor; Time Factors; Tyrosine | 2008 |
Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC.
Topics: 3' Untranslated Regions; Angiotensin II; Animals; Calreticulin; Cantharidin; Cells, Cultured; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptor, Angiotensin, Type 1; RNA Stability; Serine; src-Family Kinases; Tyrosine | 2008 |
Preparation and application of polyclonal and monoclonal sequence-specific anti-phosphoamino acid antibodies.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Antigens; Chromatography, Affinity; Cross-Linking Reagents; Culture Media, Conditioned; Humans; Mice; Molecular Sequence Data; Peptides; Phosphoamino Acids; Serine; Threonine; Tyrosine | 2004 |
Preparation and analysis of phosphorylated proteins.
Topics: Animals; Binding Sites; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Ligands; Mice; Peptide Mapping; Phosphopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; T-Lymphocytes; Threonine; Time Factors; Tyrosine | 2001 |
Identification of putative active site residues of ACAT enzymes.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Chlorocebus aethiops; CHO Cells; Cricetinae; Cricetulus; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Folding; Sequence Alignment; Serine; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Tyrosine | 2008 |
Leptin enhances human beta-defensin-2 production in human keratinocytes.
Topics: beta-Defensins; Cells, Cultured; Drug Synergism; Enzyme Activation; Humans; Interleukin-1beta; Janus Kinase 2; Keratinocytes; Leptin; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Leptin; RNA, Messenger; Serine; STAT1 Transcription Factor; STAT3 Transcription Factor; Transfection; Tyrosine; Wound Healing | 2008 |
Structural basis for controlling the dimerization and stability of the WW domains of an atypical subfamily.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Cell Cycle Proteins; Dimerization; Genetic Variation; Guanylate Kinases; Hot Temperature; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Sequence Data; Molecular Weight; Phenylalanine; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Tryptophan; Tyrosine | 2008 |
N-chloroamino acids cause oxidative protein modifications in the erythrocyte membrane.
Topics: Acetylcholinesterase; Alanine; Aspartic Acid; beta-Alanine; Chloramines; Disulfides; Erythrocyte Membrane; Humans; Kinetics; Lysine; Oxygen; Proteins; Serine; Sulfhydryl Compounds; Tyrosine | 2008 |
A dominant conformational role for amino acid diversity in minimalist protein-protein interfaces.
Topics: Amino Acids; Calorimetry; Carrier Proteins; Crystallography, X-Ray; Fibronectins; Kinetics; Maltose-Binding Proteins; Models, Molecular; Mutagenesis; Protein Binding; Protein Structure, Secondary; Serine; Thermodynamics; Tyrosine | 2008 |
The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.
Topics: Amyloid beta-Peptides; Animals; Cognition Disorders; Cytoskeleton; Hippocampus; Male; Mice; Mice, Inbred ICR; Neurofilament Proteins; Nitrates; Phosphorylation; Serine; Tyrosine | 2008 |
Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways.
Topics: Amino Acid Sequence; Animals; Cell Line; Connexin 43; Dogs; Gap Junctions; Humans; Molecular Sequence Data; Oncogene Protein pp60(v-src); Phosphorylation; Rats; Serine; Signal Transduction; Tyrosine | 2008 |
The Ser/Thr/Tyr phosphoproteome of Lactococcus lactis IL1403 reveals multiply phosphorylated proteins.
Topics: Amino Acid Sequence; Bacterial Proteins; Glycolysis; Lactococcus lactis; Phosphopeptides; Phosphorylation; Proteome; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine | 2008 |
Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; Phosphorylation; RNA, Small Interfering; Serine; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transcriptional Activation; Tyrosine | 2008 |
Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Geobacillus stearothermophilus; Glycine; Glycine Hydroxymethyltransferase; Models, Molecular; Protein Binding; Pyridoxal Phosphate; Serine; Stereoisomerism; Tetrahydrofolates; Threonine; Tyrosine | 2008 |
Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Topics: Albumins; Biotin; Chlorpyrifos; Chromatography, Liquid; Crystallography, X-Ray; Dichlorvos; Humans; Hydrogen-Ion Concentration; Isoflurophate; Models, Molecular; Molecular Structure; Organophosphorus Compounds; Reproducibility of Results; Sarin; Serine; Soman; Staining and Labeling; Tandem Mass Spectrometry; Tyrosine | 2008 |
Chances and pitfalls of chemical cross-linking with amine-reactive N-hydroxysuccinimide esters.
Topics: Amino Acid Sequence; Amino Acids; Cross-Linking Reagents; Esters; Laminin; Lysine; Molecular Sequence Data; Peptides; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Succinimides; Threonine; Tyrosine | 2008 |
The significance of disulfide bonding in biological activity of HB-EGF, a mutagenesis approach.
Topics: Animals; Cell Line; Cell Nucleus; Cloning, Molecular; Cysteine; Disulfides; ErbB Receptors; Fibroblasts; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Metallothionein; Mice; Mutagenesis, Site-Directed; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger; Serine; Tyrosine | 2008 |
Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions.
Topics: Actins; Animals; Cell Line; Cell Movement; Cortactin; Focal Adhesions; Humans; Mutation; Phosphorylation; Pseudopodia; Rats; Recombinant Fusion Proteins; Serine; Time Factors; Transfection; Tyrosine | 2008 |
Characteristic negative ion fragmentations of deprotonated peptides containing post-translational modifications: mono-phosphorylated Ser, Thr and Tyr. A joint experimental and theoretical study.
Topics: Amino Acid Sequence; Molecular Sequence Data; Peptides; Phosphorylation; Protein Processing, Post-Translational; Protons; Serine; Spectrometry, Mass, Electrospray Ionization; Threonine; Tyrosine | 2008 |
Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mutant Proteins; Phosphorylation; Point Mutation; Prostatic Neoplasms; Protein-Tyrosine Kinases; Serine; STAT3 Transcription Factor; Transplantation, Heterologous; Tyrosine | 2008 |
Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms.
Topics: Amino Acids; Crystallography, X-Ray; Cysteine; Hydrogen; Hydrogen Bonding; Hydroxyl Radical; Protein Conformation; Protein Structure, Secondary; Serine; Sulfhydryl Compounds; Threonine; Tyrosine | 2008 |
Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway.
Topics: Binding Sites; Casein Kinase I; Dipeptides; Escherichia coli; Glucose; Glycogen Synthase Kinase 3; Mass Spectrometry; Phosphorylation; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Substrate Specificity; Threonine; Tyrosine; Ubiquitin-Protein Ligases | 2008 |
Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Deoxyglucose; Gene Knockdown Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mitochondrial Diseases; Mitogen-Activated Protein Kinase 8; Phosphatidylinositol 3-Kinases; Phosphorylation; Serine; Tyrosine | 2009 |
Evaluation of the number of ionogenic groups of inulinase by acid-base titration.
Topics: Asparagine; Aspergillus; Fungal Proteins; Glutamic Acid; Glycoside Hydrolases; Histidine; Hydrogen-Ion Concentration; Lysine; Protein Denaturation; Serine; Tyrosine | 2008 |
Differential sensing of serine and tyrosine with aligned CdS nanowire arrays based on pH-dependent photoluminescence behavior.
Topics: Cadmium Compounds; Hydrogen-Ion Concentration; Luminescence; Microscopy, Electron, Transmission; Nanowires; Serine; Sulfates; Tyrosine | 2009 |
Gas-phase IR spectroscopy of deprotonated amino acids.
Topics: Amino Acids; Anions; Aspartic Acid; Cysteine; Gases; Glutamic Acid; Phenylalanine; Protons; Serine; Spectrophotometry; Spectrophotometry, Infrared; Tyrosine | 2009 |
Ser/Thr/Tyr protein phosphorylation in the archaeon Halobacterium salinarum--a representative of the third domain of life.
Topics: Amino Acids; Archaea; Biological Evolution; Genome, Bacterial; Halobacterium salinarum; Phosphorylation; Proteomics; Serine; Signal Transduction; Threonine; Tyrosine | 2009 |
FAK mediates the inhibition of glioma cell migration by truncated 24 kDa FGF-2.
Topics: Cell Line, Tumor; Cell Movement; Fibroblast Growth Factor 2; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Glioma; Humans; Neovascularization, Pathologic; Phosphorylation; Phosphotyrosine; Serine; Tyrosine | 2009 |
Analyte separation by OMNiMIPs imprinted with multiple templates.
Topics: Binding Sites; Molecular Imprinting; Molecular Structure; Naphthols; Polymers; Serine; Stereoisomerism; Surface Properties; Tryptophan; Tyrosine | 2009 |
Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.
Topics: Binding Sites; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Humans; Hydrogen Bonding; Isoxazoles; Ligands; Models, Chemical; Protein Binding; Receptors, Cytoplasmic and Nuclear; Serine; Tyrosine | 2009 |
p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.
Topics: Acetylation; Adenosine Triphosphatases; Amino Acid Sequence; Animals; Blotting, Western; Cell Cycle Proteins; Cell Line; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Humans; Kinetics; Lysine; Mass Spectrometry; Molecular Sequence Data; Mutation; Phosphorylation; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Spodoptera; Threonine; Tyrosine; Valosin Containing Protein | 2009 |
Structural characterization by IRMPD spectroscopy and DFT calculations of deprotonated phosphorylated amino acids in the gas phase.
Topics: Amino Acids; Phase Transition; Phosphorylation; Serine; Spectrophotometry, Infrared; Tandem Mass Spectrometry; Tyrosine | 2009 |
Weak functional constraints on phosphoproteomes.
Topics: Animals; Binding Sites; Evolution, Molecular; Humans; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Proteome; Serine; Threonine; Tyrosine | 2009 |
Detection and characterization of 3D-signature phosphorylation site motifs and their contribution towards improved phosphorylation site prediction in proteins.
Topics: Amino Acid Motifs; Binding Sites; Computational Biology; Databases, Protein; Phosphoproteins; Phosphorylation; Protein Kinases; Sequence Analysis, Protein; Serine; Tyrosine | 2009 |
Rat mitochondrial manganese superoxide dismutase: amino acid positions involved in covalent modifications, activity, and heat stability.
Topics: Amino Acids; Animals; Enzyme Stability; Glutamine; Hot Temperature; Kinetics; Manganese; Mitochondrial Proteins; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Serine; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds; Superoxide Dismutase; Tyrosine | 2009 |
Ser/Thr/Tyr phosphoproteome analysis of pathogenic and non-pathogenic Pseudomonas species.
Topics: Amino Acids; Bacterial Proteins; Chromatography, Liquid; Cyclic GMP; Mass Spectrometry; Phosphoamino Acids; Phosphopeptides; Phosphorylation; Protein Kinases; Proteome; Pseudomonas aeruginosa; Pseudomonas putida; Serine; Signal Transduction; Threonine; Tyrosine | 2009 |
Negative ion fragmentations of deprotonated peptides containing post-translational modifications: diphosphorylated systems containing Ser, Thr and Tyr. A characteristic phosphate/phosphate cyclisation. A joint experimental and theoretical study.
Topics: Cyclization; Ions; Peptides; Phosphates; Phosphorylation; Protein Processing, Post-Translational; Serine; Spectrum Analysis; Tandem Mass Spectrometry; Threonine; Tyrosine | 2009 |
Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity.
Topics: Arginine; Aspirin; Carboxylic Acids; Catalytic Domain; Chemistry, Pharmaceutical; Drug Design; Esters; Humans; Platelet Activation; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Serine; Thrombosis; Tyrosine | 2009 |
Occludin phosphorylation in regulation of epithelial tight junctions.
Topics: Animals; Binding Sites; Epithelium; Humans; Membrane Proteins; Mice; Mice, Knockout; Occludin; Phosphorylation; Serine; Threonine; Tight Junctions; Tyrosine | 2009 |
Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.
Topics: Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Catalytic Domain; Central Nervous System; Disease Models, Animal; Disease Progression; Facial Nerve; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Mice; Mice, Transgenic; Motor Neurons; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-met; Rhombencephalon; Serine; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2009 |
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Topics: Animals; Binding Sites; Cell Line; Cell Line, Tumor; Cell Movement; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoblotting; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; NIH 3T3 Cells; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 12; ras Proteins; Serine; Transfection; Tyrosine | 2009 |
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.
Topics: Animals; Arterioles; Biomarkers; Chemokine CCL2; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; I-kappa B Proteins; Inflammation Mediators; Macrophages; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Receptors, Leptin; Serine; Signal Transduction; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2009 |
Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins.
Topics: Adolescent; Adult; Aged; Brachial Artery; Endothelial Cells; Female; Fluorescent Antibody Technique; Humans; Linear Models; Male; Microscopy, Fluorescence; Middle Aged; Nitric Oxide Synthase Type III; Phosphorylation; Proteins; Serine; Superoxide Dismutase; Transcription Factor RelA; Tyrosine; Upper Extremity; Veins; Xanthine Oxidase; Young Adult | 2010 |
Polymorphism of HD and UCHL-1 genes in Huntington's disease.
Topics: Adult; Age of Onset; Aged; Alleles; Chi-Square Distribution; Family Health; Female; Gene Frequency; Genotype; Humans; Huntington Disease; Male; Middle Aged; Polymorphism, Genetic; Serine; Trinucleotide Repeat Expansion; Tyrosine; Ubiquitin Thiolesterase; Young Adult | 2009 |
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Topics: Actins; Amino Acid Sequence; Binding Sites; Biological Transport; Cytokines; Endocytosis; Extracellular Signal-Regulated MAP Kinases; Humans; Jurkat Cells; Microtubules; Models, Biological; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Binding; Protein Interaction Mapping; Proteomics; Receptors, Antigen, T-Cell; RNA Splicing; Sequence Homology, Amino Acid; Serine; Signal Transduction; Threonine; Transcription Factors; Tyrosine | 2009 |
Phosphorylated proteins of the mammalian mitochondrial ribosome: implications in protein synthesis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cattle; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Escherichia coli Proteins; Immunoblotting; Mammals; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Structure, Tertiary; Proteomics; Ribosomal Proteins; Sequence Alignment; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine | 2009 |
Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain.
Topics: Amino Acid Sequence; Antibodies, Phospho-Specific; Casein Kinase II; Cytoplasm; Epitopes; Humans; Molecular Sequence Data; Mutation; Neural Cell Adhesion Molecule L1; Phosphorylation; Protein Folding; Protein Kinase C-alpha; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Threonine; Tyrosine | 2009 |
Controlling peptide folding with repulsive interactions between phosphorylated amino acids and tryptophan.
Topics: Circular Dichroism; Glutamic Acid; Hydrogen-Ion Concentration; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphorylation; Phosphoserine; Protein Folding; Protein Processing, Post-Translational; Serine; Threonine; Tryptophan; Tyrosine | 2009 |
Cell biology. Evolving cell signals.
Topics: Animals; Binding Sites; Biological Evolution; CDC2 Protein Kinase; Evolution, Molecular; Fungi; Phosphorylation; Protein Binding; Protein Folding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proteins; Serine; Signal Transduction; Threonine; Tyrosine | 2009 |
Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.
Topics: Adenosine; Adenosine A3 Receptor Antagonists; Analgesics; Animals; Cell Line; Dihydropyridines; Gene Expression; Humans; Interferon-gamma; Janus Kinases; Macrophage Activation; Macrophages; Mice; Microarray Analysis; Phosphorylation; Quinazolines; Receptor, Adenosine A3; Serine; Signal Transduction; STAT1 Transcription Factor; Transcriptional Activation; Triazoles; Tyrosine | 2009 |
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Topics: Aging; alpha-Synuclein; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Humans; Neurons; Parkinson Disease; Phosphorylation; Serine; Tyrosine | 2009 |
AMINO ACID COMPOSITION OF HIGHLY PURIFIED VIRAL PARTICLES OF INFLUENZA A AND B.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Humans; Influenza, Human; Isoleucine; Leucine; Lysine; Methionine; Orthomyxoviridae; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine; Virion | 1947 |
Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
Topics: Blotting, Western; Cell Line, Tumor; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Immunoprecipitation; Interleukin-2; Janus Kinase 3; Lymphocytes; Oligonucleotides; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Phosphatase 1; Protein Phosphatase 2; Receptors, Interleukin-2; Serine; STAT5 Transcription Factor; Tumor Suppressor Proteins; Tyrosine | 2010 |
Synthesis of Lipoamino acids and their activity against cerebral ischemic injury.
Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Hydrogen Peroxide; Neuroprotective Agents; Rats; Serine; Threonine; Tyrosine | 2009 |
Effects of sulfur amino acids on tyrosyl or serine/threonine phosphorylation and translocation of cytosolic compounds to cell membrane in stimulus-treated human neutrophils.
Topics: Amino Acids, Sulfur; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Humans; Lipid Peroxidation; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; rac GTP-Binding Proteins; Respiratory Burst; Serine; Superoxides; Threonine; Tyrosine | 2009 |
FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex.
Topics: Actins; Animals; Animals, Newborn; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Intracellular Signaling Peptides and Proteins; Leucine; Matrix Metalloproteinase 2; Mechanotransduction, Cellular; Myocardium; Oligopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; RNA Interference; Serine; Sirolimus; Stress, Mechanical; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Tyrosine | 2010 |
The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold.
Topics: Amino Acid Sequence; Fibronectins; Humans; Immunoglobulin G; Peptide Library; Protein Engineering; Serine; Tyrosine | 2010 |
Kinetic and structural studies on roles of the serine ligand and a strictly conserved tyrosine residue in nitrile hydratase.
Topics: Biocatalysis; Hydro-Lyases; Kinetics; Ligands; Models, Molecular; Mutation; Protein Conformation; Rhodococcus; Serine; Spectrophotometry, Ultraviolet; Tyrosine | 2010 |
Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation.
Topics: Animals; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Lymphokines; Mice; Neovascularization, Pathologic; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Receptor, Platelet-Derived Growth Factor beta; Retinal Vessels; Serine; Tyrosine; Up-Regulation | 2010 |
DNA-catalyzed serine side chain reactivity and selectivity.
Topics: Catalysis; DNA, Catalytic; RNA; Serine; Tyrosine | 2010 |
Residual structure in a peptide fragment of the outer membrane protein X under denaturing conditions: a molecular dynamics study.
Topics: Aspartic Acid; Bacterial Outer Membrane Proteins; Escherichia coli Proteins; Hydrolases; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Peptide Fragments; Protein Denaturation; Protein Structure, Secondary; Serine; Time Factors; Tryptophan; Tyrosine; Urea | 2010 |
Two-dimensional network stability of nucleobases and amino acids on graphite under ambient conditions: adenine, L-serine and L-tyrosine.
Topics: Adenine; Amino Acids; Calibration; DNA; Graphite; Serine; Tyrosine | 2010 |
Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.
Topics: alpha-Synuclein; Animals; Dopamine; Humans; In Vitro Techniques; Lentivirus; Mice; Mice, Transgenic; Mutagenesis; Neurotransmitter Agents; Parkinson Disease; Phosphorylation; Protein Phosphatase 2; Serine; Tyrosine; Tyrosine 3-Monooxygenase | 2010 |
The functional capacity of the natural amino acids for molecular recognition.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antibodies; Antigens; Binding Sites; Binding, Competitive; Cell Line; Complementarity Determining Regions; Flow Cytometry; Humans; Molecular Sequence Data; Peptide Library; Protein Binding; Receptor, ErbB-2; Sequence Homology, Amino Acid; Serine; Tyrosine | 2010 |
Evaluation of toxicity and Stat3 activation induced by hydrogen peroxide exposure to the skin in healthy individuals.
Topics: Adult; Epidermis; Female; Humans; Hydrogen Peroxide; Male; Oxygen; Serine; Skin; Solubility; STAT3 Transcription Factor; Time Factors; Tyrosine | 2010 |
Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFkappaB activation via Src-dependent blockade of PP2A.
Topics: Cell Survival; Cells, Cultured; Genes, src; Humans; I-kappa B Kinase; I-kappa B Proteins; Mitogen-Activated Protein Kinase 3; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Serine; Signal Transduction; Tyrosine | 2010 |
Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis.
Topics: Animals; Cell Differentiation; Cells, Cultured; I-kappa B Kinase; Mice; Mice, Inbred C57BL; Mutation; Osteoclasts; Phosphorylation; Polymerase Chain Reaction; RANK Ligand; Serine; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Bacillus subtilis SSE4 produces subtulene A, a new lipopeptide antibiotic possessing an unusual C15 unsaturated beta-amino acid.
Topics: Adipates; Amino Acids; Anti-Bacterial Agents; Antifungal Agents; Asparagine; Bacillus subtilis; Lipids; Lipopeptides; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Serine; Tyrosine | 2010 |
Characterization of antimicrobial resistance of recent Salmonella enterica serovar Gallinarum isolates from chickens in South Korea.
Topics: Amino Acid Substitution; Animals; Anti-Bacterial Agents; Chickens; DNA Gyrase; DNA Primers; Drug Resistance, Bacterial; Glycine; Microbial Sensitivity Tests; Phenotype; Poultry Diseases; Quinolones; Republic of Korea; Salmonella enterica; Salmonella Infections, Animal; Serine; Sulfamethoxazole; Tyrosine | 2010 |
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Topics: Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Glioblastoma; Humans; Indoles; Maleimides; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 2010 |
Prevalence of H63D, S65C, and C282Y hereditary hemochromatosis gene variants in Madeira Island (Portugal).
Topics: Adolescent; Adult; Amino Acid Substitution; Aspartic Acid; Cysteine; Gene Frequency; Genotype; Hemochromatosis; Hemochromatosis Protein; Histidine; Histocompatibility Antigens Class I; Humans; Male; Membrane Proteins; Polymorphism, Single Nucleotide; Portugal; Prevalence; Serine; Tyrosine; Young Adult | 2011 |
Analysis of changes in tyrosine and serine phosphorylation of red cell membrane proteins induced by P. falciparum growth.
Topics: Erythrocyte Membrane; Host-Parasite Interactions; Humans; Malaria, Falciparum; Membrane Proteins; Phosphoproteins; Phosphorylation; Plasmodium falciparum; Serine; Tyrosine | 2010 |
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.
Topics: Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Cyclization; Dipeptides; Esterification; Glutamic Acid; Models, Molecular; Mycobacterium tuberculosis; Peptide Synthases; Peptides, Cyclic; Protein Conformation; RNA, Transfer, Tyr; Serine; Tyrosine; Tyrosine-tRNA Ligase | 2010 |
Acquisition of Raman spectra of amino acids using portable instruments: outdoor measurements and comparison.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; beta-Alanine; Glutamic Acid; Glutamine; Glycine; Methionine; Proline; Research Design; Robotics; Serine; Spectrum Analysis, Raman; Transportation; Tryptophan; Tyrosine; Workplace | 2010 |
Evolution of protein phosphorylation for distinct functional modules in vertebrate genomes.
Topics: Animals; Conserved Sequence; Evolution, Molecular; Gene Regulatory Networks; Genome; Humans; Phosphoproteins; Phosphorylation; Proteomics; Serine; Structure-Activity Relationship; Threonine; Tyrosine; Vertebrates | 2011 |
Tyrosine dephosphorylation is required for Bak activation in apoptosis.
Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Cell Line; Extracellular Signal-Regulated MAP Kinases; Humans; Mitochondria; Molecular Sequence Data; Phosphorylation; Protein Tyrosine Phosphatases, Non-Receptor; Serine; Threonine; Tyrosine | 2010 |
Serine phosphorylation of NPM-ALK, which is dependent on the auto-activation of the kinase activation loop, contributes to its oncogenic potential.
Topics: Cell Line, Tumor; Enzyme Activation; Humans; Neoplasm Invasiveness; Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Serine; Tyrosine | 2011 |
Phospho.ELM: a database of phosphorylation sites--update 2011.
Topics: Amino Acid Sequence; Animals; Conserved Sequence; Databases, Protein; Humans; Mice; Phosphoproteins; Phosphorylation; Protein Conformation; Sequence Analysis, Protein; Serine; Threonine; Tyrosine | 2011 |
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
Topics: Actins; Blotting, Western; Cell Line, Tumor; Cell Movement; Cortactin; Epidermal Growth Factor; Green Fluorescent Proteins; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Dynamics Simulation; Neoplasms; Phosphorylation; Protein Conformation; Pseudopodia; RNA Interference; Serine; Tyrosine; Wiskott-Aldrich Syndrome Protein | 2010 |
Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations.
Topics: Adolescent; Anodontia; Arginine; Child; Child, Preschool; Cleft Lip; Cleft Palate; Cohort Studies; Conserved Sequence; DNA-Binding Proteins; Exons; Female; Genetic Variation; Glutamine; Humans; Labial Frenum; Leucine; Male; Mutation, Missense; Phenotype; Polymorphism, Genetic; Proline; Promoter Regions, Genetic; Serine; T-Box Domain Proteins; Tongue Diseases; Transcription, Genetic; Tryptophan; Tyrosine | 2011 |
Phosphoproteomics characterization of novel phosphorylated sites of lens proteins from normal and cataractous human eye lenses.
Topics: Adult; Aged; Cataract; Chromatography, Liquid; Crystallins; Humans; Lens, Crystalline; Phosphoproteins; Phosphorylation; Proteomics; Serine; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2011 |
Rampant purifying selection conserves positions with posttranslational modifications in human proteins.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Evolution, Molecular; Humans; Models, Genetic; Phylogeny; Protein Processing, Post-Translational; Proteins; Selection, Genetic; Sequence Alignment; Serine; Threonine; Tyrosine | 2011 |
Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.
Topics: Antibodies, Phospho-Specific; Artifacts; Biocatalysis; Blotting, Western; Circular Dichroism; Cyanogen Bromide; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Halogenation; HL-60 Cells; Humans; Isoenzymes; Models, Molecular; Mutation; Phosphorylation; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Threonine; Trypsin; Tyrosine | 2011 |
Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum.
Topics: Adult; Biomarkers; Blood Glucose; Blotting, Western; Diabetes, Gestational; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Infant, Newborn; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Phosphorylation; Postpartum Period; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA; Serine; Signal Transduction; Tyrosine | 2011 |
Importance of serine727 phosphorylated STAT1 in IFNγ-induced signaling and apoptosis of human salivary gland cells.
Topics: Apoptosis; Cells, Cultured; Gene Expression Regulation; Humans; Interferon-gamma; Mutation; Phosphorylation; Salivary Glands; Serine; Signal Transduction; Sjogren's Syndrome; STAT1 Transcription Factor; Transfection; Tyrosine | 2011 |
Tumor necrosis factor-α induces increased lung vascular permeability: a role for GSK3α/β.
Topics: Animals; beta Catenin; Biomarkers; Capillary Permeability; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Lung; Male; Maleimides; Nitric Oxide Synthase Type III; Oxidation-Reduction; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Serine; Thiadiazoles; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Purification, characterization and kinetic studies of a novel poly(β) hydroxybutyrate (PHB) depolymerase PhaZ(Pen) from Penicillium citrinum S2.
Topics: Carboxylic Ester Hydrolases; Catalytic Domain; Chromatography, Affinity; Concanavalin A; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Stability; Hydrogen-Ion Concentration; Metals; Molecular Weight; Penicillium; Serine; Substrate Specificity; Temperature; Tyrosine | 2011 |
PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation.
Topics: A Kinase Anchor Proteins; Animals; beta-Transducin Repeat-Containing Proteins; Blotting, Western; Cell Line; Cyclic AMP-Dependent Protein Kinases; Endothelial Cells; Humans; Immunoprecipitation; MAP Kinase Kinase 6; Mutagenesis, Site-Directed; Neovascularization, Physiologic; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Stability; RNA, Small Interfering; Serine; Signal Transduction; Swine; Tyrosine; Ubiquitination; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
The preservation of in vivo phosphorylated and activated uncoupling protein 3 (UCP3) in isolated skeletal muscle mitochondria following administration of 3,4-methylenedioxymethamphetamine (MDMA aka ecstasy) to rats/mice.
Topics: Animals; Female; Hallucinogens; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Muscle, Skeletal; N-Methyl-3,4-methylenedioxyamphetamine; Phosphorylation; Rats; Rats, Wistar; Serine; Tyrosine; Uncoupling Protein 3 | 2012 |
Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry.
Topics: Adenosine Monophosphate; Amino Acid Sequence; Biochemical Phenomena; Mass Spectrometry; Peptides; Serine; Threonine; Tyrosine | 2011 |
Generation of mice with a conditional Stat1 null allele.
Topics: Animals; Cloning, Molecular; Gene Expression Regulation; Integrases; Interferon-beta; Interferon-gamma; Liver; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Phenotype; Phosphorylation; Serine; Spleen; STAT1 Transcription Factor; Tyrosine | 2012 |
Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.
Topics: Androstadienes; Animals; Cyclic AMP Response Element-Binding Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Indoles; Maleimides; Mice; Mice, Inbred C57BL; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; RNA, Messenger; Serine; src-Family Kinases; tau Proteins; Transcription, Genetic; Tyrosine; Wortmannin | 2011 |
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Chromatography, Liquid; Glycosylation; Humans; Molecular Sequence Data; Proteomics; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine | 2011 |
The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Confounding Factors, Epidemiologic; Cyclin-Dependent Kinase Inhibitor p27; Dasatinib; Drug Synergism; Female; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Genes, bcl-1; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Research Design; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Serine; src-Family Kinases; Thiazoles; Threonine; Tyrosine; Xenograft Model Antitumor Assays | 2011 |
Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.
Topics: Amino Acid Sequence; Animals; Bone Marrow Cells; Cell Differentiation; Cell Separation; Cytoplasm; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoblotting; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Phosphorylation; Plasma Cells; Receptors, Antigen, B-Cell; Serine; Signal Transduction; Threonine; Tyrosine | 2011 |
Frequency Determination of α-1,3 Glucosyltransferase p.Y131H and p.F304S Polymorphisms in the Croatian Population Revealed Five Novel Single Nucleotide Polymorphisms in the hALG6 Gene.
Topics: Adult; Amino Acid Substitution; Base Sequence; Croatia; Female; Gene Frequency; Genetic Predisposition to Disease; Genetics, Population; Glucosyltransferases; Humans; Male; Membrane Proteins; Middle Aged; Phenylalanine; Polymorphism, Single Nucleotide; Serine; Tryptophan; Tyrosine; Young Adult | 2012 |
Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Differentiation; Cell Movement; Cell Proliferation; Class Ia Phosphatidylinositol 3-Kinase; Curcuma; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Furans; Green Fluorescent Proteins; Heterocyclic Compounds, 2-Ring; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Medicine, Chinese Traditional; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Physiologic; Phosphorylation; Plants, Medicinal; Proto-Oncogene Protein c-fli-1; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Threonine; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing; Zebrafish | 2012 |
A novel sequence-based method for phosphorylation site prediction with feature selection and analysis.
Topics: Binding Sites; Computational Biology; Data Mining; Databases, Protein; Peptides; Phosphoproteins; Phosphorylation; Predictive Value of Tests; Protein Processing, Post-Translational; Sequence Analysis, Protein; Serine; Support Vector Machine; Threonine; Tyrosine | 2012 |
Synthetic Fab fragments that bind the HIV-1 gp41 heptad repeat regions.
Topics: Amino Acid Sequence; Antibody Affinity; Enzyme-Linked Immunosorbent Assay; HIV Envelope Protein gp41; HIV-1; Humans; Immunoglobulin Fab Fragments; Molecular Sequence Data; Peptide Library; Protein Structure, Secondary; Repetitive Sequences, Nucleic Acid; Serine; Tyrosine | 2011 |
Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Cells, Cultured; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Losartan; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Serine; Signal Transduction; Tyrosine | 2011 |
Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle.
Topics: Animals; Caffeine; Dose-Response Relationship, Drug; I-kappa B Kinase; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Tyrosine | 2011 |
Analysis of the serine/threonine/tyrosine phosphoproteome of the pathogenic bacterium Listeria monocytogenes reveals phosphorylated proteins related to virulence.
Topics: Amino Acid Sequence; Bacterial Proteins; Listeria monocytogenes; Molecular Sequence Data; Phosphopeptides; Phosphoproteins; Phosphorylation; Proteomics; Serine; Threonine; Tyrosine; Virulence | 2011 |
Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
Topics: Animals; Antioxidants; Aorta; Biopterins; Catalase; Cyclic GMP; GTP Cyclohydrolase; Hydrogen Peroxide; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Serine; Superoxide Dismutase; Superoxides; Tyrosine | 2011 |
Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.
Topics: Acetyl-CoA Carboxylase; Aldehydes; AMP-Activated Protein Kinases; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Berberine; Blood Glucose; Cholesterol; Enzyme Activation; Humans; Intercellular Adhesion Molecule-1; Ion Channels; Mice; Mitochondrial Proteins; Phosphorylation; Plaque, Atherosclerotic; Protein Transport; Serine; Threonine; Transcription, Genetic; Triglycerides; Tyrosine; Uncoupling Protein 2; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2011 |
Biphasic stress response in the soleus during reloading after hind limb unloading.
Topics: Animals; DNA-Binding Proteins; Heat Shock Transcription Factors; Hindlimb Suspension; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Insulin-Like Growth Factor I; Male; Muscle, Skeletal; Muscular Atrophy; NF-kappa B; Nitric Oxide Synthase Type II; Organ Size; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Stress, Physiological; Transcription Factors; Tyrosine | 2012 |
Phosphoproteome analysis of Streptomyces development reveals extensive protein phosphorylation accompanying bacterial differentiation.
Topics: Amino Acid Motifs; Bacterial Proteins; Computational Biology; Fractional Precipitation; Phosphoproteins; Phosphorylation; Phylogeny; Protein Kinases; Regulatory Elements, Transcriptional; Serine; Software; Spores, Bacterial; Streptomyces coelicolor; Threonine; Tyrosine | 2011 |
Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation.
Topics: Cysteine; Disulfides; Endoplasmic Reticulum; HEK293 Cells; Humans; Models, Biological; Mutation; Plasmids; Protein Conformation; Protein Folding; Protein Multimerization; Protein Subunits; Serine; Transfection; Tyrosine; von Willebrand Diseases; von Willebrand Factor; Weibel-Palade Bodies | 2012 |
Translation initiation factor eIF-5A, the hypusine-containing protein, is phosphorylated on serine and tyrosine and O-glycosylated in Trichomonas vaginalis.
Topics: Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Glycosylation; Isoelectric Point; Peptide Initiation Factors; Phosphorylation; Protein Processing, Post-Translational; RNA-Binding Proteins; Serine; Trichomonas vaginalis; Tyrosine | 2012 |
[Determination of amino acid contents in cottonseeds using near infrared reflectance spectroscopy].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Calibration; Cottonseed Oil; Cystine; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Serine; Spectroscopy, Near-Infrared; Threonine; Tyrosine; Valine | 2011 |
Model studies on iTRAQ modification of peptides: sequence-dependent reaction specificity.
Topics: Acylation; Amino Acid Sequence; Escherichia coli Proteins; Hydroxylamine; Oligopeptides; Peptide Fragments; Peptide Mapping; Reference Standards; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staining and Labeling; Tandem Mass Spectrometry; Threonine; Tyrosine | 2012 |
Interactions of organophosphates with keratins in the cornified epithelium of human skin.
Topics: Binding Sites; Chemical Warfare Agents; Cysteine; Humans; Keratins; Organophosphates; Organothiophosphorus Compounds; Paraoxon; Peptide Fragments; Pronase; Serine; Skin; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2012 |
Reversible Ser/Thr SHIP phosphorylation: a new paradigm in phosphoinositide signalling?: Targeting of SHIP1/2 phosphatases may be controlled by phosphorylation on Ser and Thr residues.
Topics: Animals; Cell Differentiation; Cell Membrane; Cell Nucleus; Enzyme Activation; Humans; Inositol Polyphosphate 5-Phosphatases; Mice; Mice, Knockout; Phosphatidylinositol Phosphates; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Interaction Mapping; PTEN Phosphohydrolase; Serine; Signal Transduction; Substrate Specificity; Threonine; Tyrosine | 2012 |
Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; eIF-2 Kinase; Extracellular Signal-Regulated MAP Kinases; Insulin Resistance; Male; Muscle, Skeletal; Obesity; Phosphorylation; Rats; Rats, Zucker; Serine; Signal Transduction; Threonine; Tyrosine; Ubiquitination | 2012 |
EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung cancer cell growth.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Serine; Tandem Mass Spectrometry; Tyrosine | 2012 |
N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells.
Topics: Amino Acid Substitution; Animals; Caveolin 2; Cell Proliferation; Cells, Cultured; Endothelial Cells; Gene Knockout Techniques; Humans; Mice; Mutagenesis, Site-Directed; Mutant Proteins; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Tyrosine Phosphatases; Recombinant Proteins; Serine; Serpin E2; Smad3 Protein; Transcriptional Activation; Transforming Growth Factor beta; Tyrosine | 2012 |
Genistein promotes insulin action through adenosine monophosphate-activated protein kinase activation and p70 ribosomal protein S6 kinase 1 inhibition in the skeletal muscle of mice fed a high energy diet.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Down-Regulation; Energy Intake; Fructose; Genistein; Glycine max; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred Strains; Muscle, Skeletal; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Ribosomal Protein S6 Kinases, 70-kDa; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tyrosine | 2012 |
Cell signaling, post-translational protein modifications and NMR spectroscopy.
Topics: Acetylation; Acylation; Alkylation; Amino Acids; Arginine; Cell Communication; Eukaryotic Cells; Glycosylation; Histidine; Lysine; Magnetic Resonance Spectroscopy; Methylation; Phosphorylation; Protein Processing, Post-Translational; Proteins; Serine; Threonine; Tyrosine | 2012 |
CDPKs are dual-specificity protein kinases and tyrosine autophosphorylation attenuates kinase activity.
Topics: Arabidopsis Proteins; Calcium; Calcium-Binding Proteins; Immunoblotting; Mass Spectrometry; Mutagenesis, Site-Directed; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Proteins; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine | 2012 |
Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote.
Topics: Amino Acid Sequence; Anticodon; Arginine; Base Sequence; Codon; Cytoplasm; Isoenzymes; Molecular Sequence Data; Mutation; RNA Editing; RNA, Transfer; RNA, Transfer, Thr; Saccharomyces cerevisiae; Sequence Alignment; Serine; Threonine; Threonine-tRNA Ligase; Transfer RNA Aminoacylation; Tyrosine | 2013 |
CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Gα(14/16) signaling and IL-6 release.
Topics: Antibodies; Cell Nucleus; Chemokines, CC; Cytosol; Gene Expression; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Interleukin-6; Interleukin-8; K562 Cells; Macrophage Inflammatory Proteins; Macrophages; Pertussis Toxin; Phosphorylation; Plasmids; Protein Isoforms; Receptors, CCR1; Serine; Signal Transduction; STAT3 Transcription Factor; Transfection; Tyrosine | 2012 |
Novel Phosphorylations of IKKγ/NEMO.
Topics: Amino Acid Substitution; Herpesvirus 8, Human; Humans; I-kappa B Kinase; NF-kappa B; Phosphorylation; Protein Processing, Post-Translational; Serine; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice.
Topics: Animals; Antioxidants; Dietary Supplements; Hyperglycemia; Hypoglycemic Agents; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Liver Glycogen; Male; Mice; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Random Allocation; Serine; Signal Transduction; Tyrosine; Xanthophylls | 2012 |
Influence of the O-phosphorylation of serine, threonine and tyrosine in proteins on the amidic ¹⁵N chemical shielding anisotropy tensors.
Topics: Anisotropy; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphates; Phosphorylation; Proteins; Serine; Solvents; Threonine; Tyrosine | 2013 |
Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.
Topics: Carrier Proteins; Histones; Humans; Kinetics; mRNA Cleavage and Polyadenylation Factors; Mutagenesis, Site-Directed; Mutant Proteins; Nuclear Proteins; Peptide Fragments; Phosphorylation; Point Mutation; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Processing, Post-Translational; Recombinant Proteins; RNA Folding; RNA-Binding Proteins; RNA, Messenger; Serine; Threonine; Tyrosine | 2013 |
The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation.
Topics: 14-3-3 Proteins; Endopeptidases; Endosomal Sorting Complexes Required for Transport; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Mutagenesis; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Serine; src-Family Kinases; Transforming Growth Factor alpha; Tyrosine; Ubiquitin Thiolesterase | 2013 |
Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Eukaryotic Translation Initiation Factor 5A; Molecular Sequence Data; Peptide Initiation Factors; Phosphorylation; Polyribosomes; Protein Biosynthesis; RNA-Binding Proteins; Serine; Trypanosoma cruzi; Tyrosine | 2013 |
Amino acid building blocks for Fmoc solid-phase synthesis of peptides phosphocholinated at serine, threonine, and tyrosine.
Topics: Amino Acids; Fluorenes; Peptides; Phosphorylcholine; Serine; Solid-Phase Synthesis Techniques; Threonine; Tyrosine | 2013 |
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Mice; Muscle, Skeletal; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Signal Transduction; Tyrosine | 2012 |
The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Cerebellum; Guanine Nucleotide Exchange Factors; Long-Term Synaptic Depression; Mice; Mice, Knockout; Models, Neurological; Neuronal Plasticity; Patch-Clamp Techniques; Phosphorylation; Protein Interaction Domains and Motifs; Protein Subunits; Protein Tyrosine Phosphatase, Non-Receptor Type 4; Purkinje Cells; Receptors, AMPA; Receptors, Glutamate; Serine; Signal Transduction; Tyrosine | 2013 |
Global phosphoproteomic analysis reveals diverse functions of serine/threonine/tyrosine phosphorylation in the model cyanobacterium Synechococcus sp. strain PCC 7002.
Topics: Bacteria; Bacterial Proteins; Gene Ontology; Phosphoproteins; Phosphorylation; Photosynthesis; Proteomics; Serine; Signal Transduction; Synechococcus; Threonine; Tyrosine | 2013 |
PTPα-mediated Src activation by EGF in human breast cancer cells.
Topics: Acetophenones; Benzopyrans; Biocatalysis; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Humans; Immunoblotting; Mutation; Phosphorylation; Protein Binding; Protein Kinase C-delta; Proto-Oncogene Proteins pp60(c-src); Receptor-Like Protein Tyrosine Phosphatases, Class 4; RNA Interference; Serine; Signal Transduction; Tyrosine | 2013 |
Periapical lesions decrease insulin signal and cause insulin resistance.
Topics: Adipose Tissue, White; Animals; Dental Pulp Exposure; Dental Pulp Necrosis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leukocytes, Mononuclear; Male; Neutrophils; Periapical Diseases; Phosphorylation; Rats; Rats, Wistar; Receptor, Insulin; Serine; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Topics: Animals; Astrocytes; Cell Line, Tumor; Ciliary Neurotrophic Factor; Coculture Techniques; Focal Adhesion Protein-Tyrosine Kinases; Mice, Inbred C57BL; Neurogenesis; Neuroglia; Neurons; Phosphorylation; Quinolones; Rats; Receptors, Vitronectin; Serine; Signal Transduction; STAT3 Transcription Factor; Sulfones; Thy-1 Antigens; Tyrosine | 2013 |
Probing the recognition of post-translational modifications by combining sortase-mediated ligation and phage-assisted selection.
Topics: Amino Acid Sequence; Aminoacyltransferases; Bacterial Proteins; Bacteriophages; Cysteine Endopeptidases; Molecular Probes; Peptide Library; Peptides; Phosphorylation; Protein Processing, Post-Translational; Proteins; Serine; Tyrosine | 2013 |
Structural evidence for the involvement of the residues Ser187 and Tyr422 in substrate recognition in the 3-methylcrotonyl-coenzyme A carboxylase from Pseudomonas aeruginosa.
Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Carbon-Carbon Ligases; Catalytic Domain; Escherichia coli; Gene Expression; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Data; Mutagenesis, Site-Directed; Pseudomonas aeruginosa; Recombinant Proteins; Serine; Substrate Specificity; Tyrosine | 2013 |
Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase 5; Dendrites; Dentate Gyrus; Female; Fluorescent Antibody Technique; Focal Adhesion Protein-Tyrosine Kinases; Hippocampus; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuropilin-1; Neuropilin-2; Phosphorylation; Purines; Rats; Rats, Sprague-Dawley; Retroviridae; RNA, Small Interfering; Roscovitine; Semaphorins; Serine; Signal Transduction; Stem Cells; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Topics: Angiotensin II; Animals; Cattle; Cell Line; Endothelial Cells; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Zucker; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2013 |
Mechanism of dual specificity kinase activity of DYRK1A.
Topics: Animals; Biocatalysis; Dyrk Kinases; Escherichia coli; HeLa Cells; Humans; Kinetics; Models, Molecular; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Serine; Substrate Specificity; Thermodynamics; Threonine; Transfection; Tyrosine | 2013 |
Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity.
Topics: Animals; Cardiomegaly; Echocardiography; Immunohistochemistry; Leptin; Mice; Mice, Transgenic; Mutation; Obesity; Phenotype; Receptors, Leptin; Serine; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2013 |
Serine 9 and tyrosine 216 phosphorylation of GSK-3β differentially regulates autophagy in acquired cadmium resistance.
Topics: Aged; Animals; Autophagy; Cadmium; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred C57BL; Phosphorylation; Serine; Tyrosine | 2013 |
Evolutionary conservation of mammalian sperm proteins associates with overall, not tyrosine, phosphorylation in human spermatozoa.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Conserved Sequence; Electrophoresis, Gel, Two-Dimensional; Evolution, Molecular; Fertility; Gene Expression Regulation; Humans; Male; Molecular Sequence Annotation; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Serine; Spermatozoa; Threonine; Tyrosine | 2013 |
Casein kinase 2 associates with the yeast chromatin reassembly factor Spt2/Sin1 to regulate its function in the repression of spurious transcription.
Topics: Casein Kinase II; Catalytic Domain; Chromatin; Chromatography, Affinity; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Open Reading Frames; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Subunits; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Transcription, Genetic; Tyrosine | 2013 |
Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication.
Topics: Animals; Apoptosis; Calnexin; Cell Line; Cell Proliferation; Endoplasmic Reticulum; fms-Like Tyrosine Kinase 3; Glycosylation; Heat-Shock Proteins; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-pim-1; Serine; Signal Transduction; STAT5 Transcription Factor; Tyrosine | 2013 |
Phosphorylation of cystic fibrosis transmembrane conductance regulator (CFTR) serine-511 by the combined action of tyrosine kinases and CK2: the implication of tyrosine-512 and phenylalanine-508.
Topics: Casein Kinase II; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Phenylalanine; Phosphorylation; Protein-Tyrosine Kinases; Serine; Tyrosine | 2013 |
Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons.
Topics: 4-Aminopyridine; Action Potentials; Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cells, Cultured; Hippocampus; Neurons; Phosphorylation; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Serine; src-Family Kinases; STAT3 Transcription Factor; Tyrosine | 2014 |
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; Class Ia Phosphatidylinositol 3-Kinase; COS Cells; Female; Mice, Inbred Strains; Mice, Nude; Morpholines; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Quinazolines; RNA Interference; Serine; Tyrosine | 2014 |
Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.
Topics: Adenosine Triphosphatases; Multiprotein Complexes; Nuclear Proteins; Phosphorylation; Ribonucleoproteins; RNA Polymerase II; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Transcription Factors; Transcription, Genetic; Tyrosine | 2013 |
Newly identified phosphorylation site in the vesicular stomatitis virus P protein is required for viral RNA synthesis.
Topics: Amino Acid Motifs; Humans; Mass Spectrometry; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; RNA, Viral; Serine; Tyrosine; Vesicular Stomatitis; Vesicular stomatitis Indiana virus; Viral Structural Proteins; Virus Replication | 2014 |
Evidence of multimeric forms of HSP70 with phosphorylation on serine and tyrosine residues--implications for roles of HSP70 in detection of GI cancers.
Topics: Antibodies, Monoclonal; Cross Reactions; Gastrointestinal Neoplasms; HSP70 Heat-Shock Proteins; Humans; Phosphorylation; Serine; Tyrosine | 2013 |
Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Signal Transduction; Stearic Acids; Tyrosine | 2013 |
STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates.
Topics: Amino Acid Substitution; Animals; Benzamides; Blotting, Western; Cell Differentiation; Cell Proliferation; Cells, Cultured; Diphenylamine; Embryonic Stem Cells; Fluorescent Antibody Technique; Gene Expression; Leukemia Inhibitory Factor; Mice, Knockout; Mice, Transgenic; Nestin; Neurons; Phosphorylation; Pluripotent Stem Cells; Reverse Transcriptase Polymerase Chain Reaction; Serine; STAT3 Transcription Factor; Tyrosine | 2014 |
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
Topics: Amino Acid Substitution; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Binding Sites; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Hydrogen Bonding; Leucine; Meloxicam; Mice; Mutation; Piroxicam; Protein Structure, Secondary; Serine; Thiazines; Thiazoles; Tyrosine; Water | 2014 |
Global phosphoproteomic analysis of Daphnia pulex reveals evolutionary conservation of Ser/Thr/Tyr phosphorylation.
Topics: Amino Acid Sequence; Animals; Arthropod Proteins; Biological Evolution; Conserved Sequence; Daphnia; Gene Expression Regulation; Humans; Molecular Sequence Annotation; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Proteomics; Serine; Threonine; Titanium; Tyrosine | 2014 |
A "SYDE" effect of hierarchical phosphorylation: possible relevance to the cystic fibrosis basic defect.
Topics: Amino Acid Sequence; Aspartic Acid; Casein Kinase II; Consensus Sequence; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dictyostelium; Glutamic Acid; Humans; Molecular Sequence Data; Phosphorylation; Protein Interaction Domains and Motifs; Serine; Tyrosine | 2014 |
Insights into the coassembly of hydrogelators and surfactants based on aromatic peptide amphiphiles.
Topics: Circular Dichroism; Fluorenes; Gels; Hydrogels; Leucine; Microscopy, Atomic Force; Peptides; Pyrenes; Serine; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Tyrosine | 2014 |
The nucleotide-binding oligomerization domain-containing protein 1 (NOD1) polymorphism S7N does not affect receptor function.
Topics: Amino Acid Sequence; Binding Sites; Black or African American; HEK293 Cells; Humans; Immunoblotting; Luciferases; Models, Molecular; Molecular Sequence Data; Mutation; NF-kappa B; Nod1 Signaling Adaptor Protein; Phosphorylation; Polymorphism, Genetic; Protein Structure, Tertiary; Serine; Signal Transduction; Threonine; Tyrosine; White People | 2014 |
Phosphoregulation of the human SMN complex.
Topics: Amino Acid Sequence; Coiled Bodies; HeLa Cells; Humans; Molecular Sequence Data; Mutation; Phosphoproteins; Phosphorylation; Proteome; Ribonucleoproteins, Small Nuclear; Serine; SMN Complex Proteins; Threonine; Tyrosine | 2014 |
Traceless chemical ligation from S-, O-, and N-acyl isopeptides.
Topics: Acylation; Biochemistry; Cysteine; Homocysteine; Peptides; Peptides, Cyclic; Serine; Solid-Phase Synthesis Techniques; Tryptophan; Tyrosine | 2014 |
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.
Topics: Animals; Anisomycin; Antigens, CD; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Receptor, Insulin; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Thapsigargin; Threonine; TOR Serine-Threonine Kinases; Tunicamycin; Tyrosine | 2014 |
Ser/Thr/Tyr phosphoproteome characterization of Acinetobacter baumannii: comparison between a reference strain and a highly invasive multidrug-resistant clinical isolate.
Topics: Acinetobacter baumannii; Amino Acid Sequence; Chromatography; Drug Resistance, Multiple, Bacterial; Glycolysis; Mass Spectrometry; Molecular Sequence Data; Peptides; Phenotype; Phosphorylation; Proteome; Proteomics; Serine; Tandem Mass Spectrometry; Threonine; Titanium; Tyrosine | 2014 |
Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction.
Topics: Animals; Diaphragm; Interleukin-6; Janus Kinases; Male; Mitochondria; Muscle Weakness; Muscular Atrophy; Oxidative Stress; Phosphorylation; Proteolysis; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Serine; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2014 |
Chk2 prevents mitotic exit when the majority of kinetochores are unattached.
Topics: Anaphase; Animals; Aurora Kinase B; Birds; CDC2 Protein Kinase; Cell Cycle Proteins; Checkpoint Kinase 2; Chromosome Segregation; Gene Expression Regulation; HCT116 Cells; Humans; Kinetochores; Mad2 Proteins; Microtubules; Mitosis; Mutagenesis, Site-Directed; Nocodazole; Phosphorylation; Point Mutation; Prometaphase; Protein Serine-Threonine Kinases; Protein Stability; Protein-Tyrosine Kinases; RNA Interference; Serine; Time Factors; Transfection; Tubulin Modulators; Tyrosine | 2014 |
Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K.
Topics: Animals; Leptin; Mice; Mitogen-Activated Protein Kinase 3; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Serine; Signal Transduction; STAT3 Transcription Factor; Tyrosine | 2014 |
Reaction mechanism of Zn2+-dependent d-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate.
Topics: Binding Sites; Biocatalysis; Catalytic Domain; Hydro-Lyases; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Mutation, Missense; Nitrogen; Protein Binding; Proteins; Pyridines; Pyridoxal Phosphate; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Spectrophotometry; Tyrosine; Zinc | 2014 |
Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Erlotinib Hydrochloride; Female; Fibroblasts; Humans; Interleukin-6; Lung Neoplasms; Mice; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; Serine; STAT3 Transcription Factor; Tyrosine | 2014 |
Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD.
Topics: Amino Acid Sequence; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Phosphorylation; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Serine; Transcription Factors; Transcription, Genetic; Tyrosine | 2014 |
[Plasma amino acid profiling of "same symptom for different disease" in Uyghur medicine based on high-performance liquid chromatography].
Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography, High Pressure Liquid; Cystine; Humans; Isoleucine; Leucine; Medicine, Chinese Traditional; Neoplasms; Serine; Tyrosine; Valine | 2014 |
Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity.
Topics: Apoptosis; Catalysis; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Jurkat Cells; Neoplasms; Nitrogen; Oxidation-Reduction; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Serine; Superoxide Dismutase; Superoxide Dismutase-1; Tyrosine | 2014 |
Rationalization of the pKa values of alcohols and thiols using atomic charge descriptors and its application to the prediction of amino acid pKa's.
Topics: Alcohols; Cysteine; Models, Chemical; Phenols; Proteins; Quantum Theory; Serine; Static Electricity; Sulfhydryl Compounds; Thermodynamics; Tyrosine; Water | 2014 |
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Topics: Alleles; Animals; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Myeloid Cells; Myeloproliferative Disorders; Phosphorylation; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Serine; STAT3 Transcription Factor; Stem Cells; Tyrosine | 2014 |
Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling.
Topics: Algorithms; HeLa Cells; Humans; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Proteome; Sequence Analysis, Protein; Serine; Signal Transduction; Threonine; Tyrosine | 2014 |
PP2A inactivation by ROS accumulation.
Topics: Apoptosis; Gene Expression Regulation, Neoplastic; Humans; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Serine; Tyrosine | 2014 |
Efficient modification of alpha-synuclein serine 129 by protein kinase CK1 requires phosphorylation of tyrosine 125 as a priming event.
Topics: alpha-Synuclein; Casein Kinase I; Cell Line, Transformed; Green Fluorescent Proteins; Humans; Magnetic Resonance Spectroscopy; Phosphorylation; Serine; Transfection; Tyrosine | 2014 |
The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1.
Topics: Arabidopsis; Arabidopsis Proteins; Chitin; Models, Molecular; Mutation; Phosphorylation; Plant Immunity; Protein Binding; Protein Kinases; Protein Multimerization; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Receptors, Cell Surface; Serine; Signal Transduction; Tyrosine | 2014 |
Quantitative proteome analyses identify PrfA-responsive proteins and phosphoproteins in Listeria monocytogenes.
Topics: Bacterial Proteins; Binding Sites; Chromatography, Liquid; Culture Media; Glucose; Listeria monocytogenes; Mutation; Peptide Termination Factors; Peptides; Phosphoproteins; Phosphorylation; Proteome; Proteomics; Purines; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine; Virulence | 2014 |
Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.
Topics: Amino Acid Motifs; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholesterol; Conserved Sequence; Gene Expression; HEK293 Cells; Humans; Molecular Sequence Data; Mutation; Neoplasm Proteins; Phenylalanine; Protein Folding; Recombinant Proteins; Serine; Sf9 Cells; Spodoptera; Tyrosine | 2015 |
Using support vector machines to identify protein phosphorylation sites in viruses.
Topics: Amino Acid Sequence; Databases, Protein; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Serine; Support Vector Machine; Threonine; Tyrosine; Viral Proteins | 2015 |
Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1.
Topics: Animals; Carrageenan; GATA2 Transcription Factor; Gene Expression; GRB10 Adaptor Protein; Hep G2 Cells; Humans; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Models, Statistical; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Serine; Signal Transduction; Tyrosine | 2015 |
Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity.
Topics: Animals; Cardiomegaly; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Humans; Ligands; Mutation; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Rats; Receptors, Adrenergic, beta; Serine; Signal Transduction; src Homology Domains; Threonine; Tyrosine | 2015 |
Phosphorylation site prediction in plants.
Topics: Binding Sites; Computational Biology; Databases, Protein; Internet; Machine Learning; Models, Statistical; Phosphorylation; Plant Proteins; Plants; Serine; Software; Threonine; Tyrosine | 2015 |
Regulatory role of guanine nucleotide exchange factor (GEF) Dock180 phosphorylation on Tyr/Ser in mediation of gastric mucosal Rac1 activation in response to Helicobacter pylori and ghrelin.
Topics: Animals; Gastric Mucosa; Ghrelin; Guanine Nucleotide Exchange Factors; Helicobacter Infections; Helicobacter pylori; Inflammation; Lipopolysaccharides; Phosphorylation; Protein Kinase C-delta; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rats; Serine; src-Family Kinases; Tyrosine; Up-Regulation | 2015 |
[Identifying phosphopeptide by searching a site annotated protein database].
Topics: Databases, Protein; Phosphopeptides; Phosphorylation; Proteomics; Reproducibility of Results; Serine; Threonine; Tyrosine | 2015 |
Useful agents against aflatoxin B1 - antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine.
Topics: Aflatoxin B1; Anti-Bacterial Agents; Antidotes; Azo Compounds; Bacteria; Female; Humans; Male; Manganese; Serine; Thiosemicarbazones; Threonine; Tyrosine | 2016 |
Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Connexin 43; Endothelial Cells; Endothelium, Vascular; Female; MAP Kinase Signaling System; Phosphorylation; Pre-Eclampsia; Pregnancy; Protein Processing, Post-Translational; Serine; Sheep, Domestic; src-Family Kinases; Tyrosine; Uterine Artery; Vascular Endothelial Growth Factor A | 2015 |
Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Renal Cell; Catenins; Cell Transformation, Neoplastic; Delta Catenin; Female; Humans; Immunoenzyme Techniques; Immunoprecipitation; Kidney Neoplasms; Phosphoproteins; Phosphorylation; Protein Binding; Serine; Threonine; Tissue Array Analysis; Tumor Cells, Cultured; Tyrosine | 2015 |
A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells.
Topics: Acetates; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; MAP Kinase Signaling System; Phosphorylation; Resveratrol; Serine; STAT3 Transcription Factor; Stilbenes; Tyrosine | 2015 |
Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
Topics: Amino Acid Sequence; Cell Line; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-2 Receptor beta Subunit; Janus Kinase 3; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; Phosphorylation; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Serine; Signal Transduction; STAT5 Transcription Factor; Threonine; Tyrosine | 2015 |
Theoretical study of inhibition efficiencies of some amino acids on corrosion of carbon steel in acidic media: green corrosion inhibitors.
Topics: Acids; Carbon; Corrosion; Models, Molecular; Serine; Steel; Tryptophan; Tyrosine | 2016 |
Site-Specific Ser/Thr/Tyr Phosphoproteome of Sinorhizobium meliloti at Stationary Phase.
Topics: Bacterial Proteins; Computational Biology; Phosphoproteins; Phosphorylation; Proteome; Sequence Analysis, Protein; Serine; Sinorhizobium meliloti; Subcellular Fractions; Tandem Mass Spectrometry; Threonine; Tyrosine | 2015 |
Arabidopsis Yak1 protein (AtYak1) is a dual specificity protein kinase.
Topics: Annexins; Arabidopsis; Arabidopsis Proteins; Electrophoresis, Gel, Two-Dimensional; Mutation; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Threonine; Tyrosine | 2015 |
Stereoselective recognition of the Ac-Glu-Tyr-OH dipeptide by pseudopeptidic cages.
Topics: Amides; Cyclohexanes; Dipeptides; Glutamine; Models, Biological; Molecular Structure; Serine; Stereoisomerism; Threonine; Tyrosine | 2015 |
The Sensor Histidine Kinases AHK2 and AHK3 Proceed into Multiple Serine/Threonine/Tyrosine Phosphorylation Pathways in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Histidine Kinase; Phosphorylation; Protein Kinases; Serine; Threonine; Tyrosine | 2016 |
Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain.
Topics: Amino Acid Sequence; Binding Sites; Cell Cycle Proteins; Gamma Rays; Gene Expression Regulation; HeLa Cells; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasm Proteins; Peptides; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Proteomics; RNA Polymerase II; Sequence Alignment; Serine; Signal Transduction; Tyrosine | 2015 |
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
Topics: Animals; Cell Line, Tumor; Cytoplasm; E1A-Associated p300 Protein; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Heparin-binding EGF-like Growth Factor; Humans; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Membrane Glycoproteins; Mice, Nude; Multiprotein Complexes; Neoplasm Proteins; Phosphorylation; Prognosis; Proline; Protein Serine-Threonine Kinases; Protein Stability; Protein-Tyrosine Kinases; RNA Interference; RNA, Long Noncoding; Serine; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Triple Negative Breast Neoplasms; Tyrosine | 2016 |
Identification of Connexin43 Phosphorylation and S-Nitrosylation in Cultured Primary Vascular Cells.
Topics: Biotin; Blotting, Western; Cells, Cultured; Connexin 43; Cysteine; Fluorescent Antibody Technique; Human Umbilical Vein Endothelial Cells; Humans; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; S-Nitrosothiols; Serine; Threonine; Tyrosine | 2016 |
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Autophagy; Globins; Humans; Lewy Bodies; Nerve Tissue Proteins; Neuroglobin; Oxidation-Reduction; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Serine; Tyrosine | 2016 |
Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses.
Topics: Capsid; Dependovirus; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Genome, Human; HEK293 Cells; Humans; Lysine; Serine; Serogroup; Threonine; Transduction, Genetic; Tyrosine | 2016 |
High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach.
Topics: Animals; Apoptosis; Cell Line, Transformed; Forkhead Box Protein O1; Forkhead Box Protein O3; Gene Expression Regulation; Glucose; Humans; Hyperglycemia; Insulin; Insulin Receptor Substrate Proteins; Male; Phosphatidylinositol 3-Kinases; Phosphorylation; Podocytes; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Serine; Signal Transduction; Tissue Culture Techniques; Tyrosine | 2016 |
Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins.
Topics: Amino Acid Motifs; Animals; Antigen Presentation; Cytoplasm; H-2 Antigens; HLA Antigens; Humans; Immunologic Surveillance; Immunological Synapses; Mice; Nervous System; PDZ Domains; Phosphorylation; Protein Interaction Domains and Motifs; Sequence Analysis, Protein; Serine; Signal Transduction; Tyrosine | 2016 |
Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD).
Topics: Animals; Asparagine; Crystallography, X-Ray; Drug Design; Enzyme Assays; Humans; Hydrogen Bonding; MAP Kinase Kinase Kinases; Mice; Microsomes, Liver; Molecular Structure; Protein Kinase Inhibitors; Pyrimidinones; Serine; Solubility; Structure-Activity Relationship; Thiophenes; Tyrosine | 2016 |
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acid Substitution; Anemia, Aplastic; Athletes; Athletic Performance; Bone Marrow Transplantation; Carcinoma, Non-Small-Cell Lung; Catalytic Domain; Cell Count; Child; Child, Preschool; Escherichia coli; Female; Gene Expression; Graft Survival; Graft vs Host Disease; Histocompatibility Testing; Humans; Hydrogen Bonding; Immunosuppression Therapy; Inosine Monophosphate; Integrin alphaVbeta3; Kinetics; Knee Joint; Lung Neoplasms; Lymphatic Metastasis; Male; Mediastinal Neoplasms; Middle Aged; Molecular Dynamics Simulation; Muscle, Skeletal; Mutation; Organotechnetium Compounds; Pentosyltransferases; Peptides, Cyclic; Phenylalanine; Plasmodium falciparum; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Protozoan Proteins; Radiopharmaceuticals; Recombinant Proteins; Running; Sensitivity and Specificity; Serine; Siblings; Single Photon Emission Computed Tomography Computed Tomography; Soccer; Structure-Activity Relationship; Substrate Specificity; Thermodynamics; Threonine; Time Factors; Torque; Treatment Outcome; Tryptophan; Tyrosine; Young Adult | 2016 |
The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1.
Topics: Arsenites; Binding Sites; Membrane Proteins; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Tyrosine | 2016 |
Helicobacter pylori-induced changes in microtubule dynamics conferred by α-tubulin phosphorylation on Ser/Tyr mediate gastric mucosal secretion of matrix metalloproteinase-9 (MMP-9) and its modulation by ghrelin.
Topics: Animals; Gastric Mucosa; Ghrelin; Helicobacter pylori; Matrix Metalloproteinase 9; Microtubules; Phosphorylation; Rats; Serine; Tubulin; Tyrosine | 2016 |
Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.
Topics: Animals; Calcineurin; Cells, Cultured; Mice; Microfilament Proteins; Phosphorylation; Podocytes; Receptor Cross-Talk; rhoA GTP-Binding Protein; Serine; Signal Transduction; Threonine; Tyrosine | 2017 |
Podocyte biology: Dynamic control of actin remodelling.
Topics: Actins; Phosphorylation; Podocytes; Serine; Threonine; Tyrosine | 2016 |
Understanding the Phosphorylation Mechanism by Using Quantum Chemical Calculations and Molecular Dynamics Simulations.
Topics: ADP Ribose Transferases; Antigens, Nuclear; Autoantigens; GPI-Linked Proteins; Humans; Immediate-Early Proteins; Molecular Dynamics Simulation; Phosphorylation; Quantum Theory; Serine; Tumor Suppressor Proteins; Tyrosine | 2017 |
Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors.
Topics: Anthocyanins; Antioxidants; Cells, Cultured; Endothelium, Vascular; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Palmitic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Tyrosine | 2017 |
Modulation of long-term endothelial-barrier integrity is conditional to the cross-talk between Akt and Src signaling.
Topics: Angiopoietin-1; Capillary Permeability; Cells, Cultured; Endothelial Cells; Humans; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Serine; Signal Transduction; src-Family Kinases; Time Factors; Transfection; Transforming Growth Factor beta1; Tyrosine; Vascular Endothelial Growth Factor A | 2017 |
ERK1/2, JNK and STAT3 activation and correlation with tumor differentiation in oral SCC.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Differentiation; Female; Humans; Immunohistochemistry; Male; MAP Kinase Signaling System; Middle Aged; Mitogen-Activated Protein Kinases; Mouth Neoplasms; Neoplasm Grading; Phosphorylation; Serine; STAT3 Transcription Factor; Tyrosine | 2017 |
GC-MS Metabolomics Identifies Metabolite Alterations That Precede Subclinical Mastitis in the Blood of Transition Dairy Cows.
Topics: Animal Feed; Animals; Biomarkers; Cattle; Cell Count; Dairying; Early Diagnosis; Female; Gas Chromatography-Mass Spectrometry; Lactation; Mastitis, Bovine; Metabolomics; Milk; Parturition; Phenylalanine; Principal Component Analysis; Prognosis; Serine; Tyrosine; Valine | 2017 |
Specific interactions between vitamin-D receptor and its ligands: Ab initio molecular orbital calculations in water.
Topics: Arginine; Binding Sites; Bone Density Conservation Agents; Calcitriol; Computer Simulation; Databases, Protein; Energy Transfer; Humans; Isomerism; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Protein Conformation; Quantum Theory; Receptors, Calcitriol; Recombinant Proteins; Serine; Tetrazoles; Tyrosine | 2017 |
Fascin phosphorylation sites combine to regulate esophageal squamous cancer cell behavior.
Topics: Actins; Carrier Proteins; Cell Line, Tumor; Cell Movement; Epithelial Cells; Esophagus; Humans; Microfilament Proteins; Mutation; Phosphorylation; Protein Processing, Post-Translational; Pseudopodia; Serine; Tyrosine | 2017 |
Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries.
Topics: Animals; Blotting, Western; Class Ia Phosphatidylinositol 3-Kinase; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Homocysteine; Hypoxia; In Vitro Techniques; Myosin Light Chains; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Swine; Time Factors; Tyrosine; Vasoconstriction | 2017 |
Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p.
Topics: Phosphorylation; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Proteolysis; RNA Polymerase II; Saccharomyces cerevisiae Proteins; Serine; Threonine; Transcription Factors; Transcription, Genetic; Tyrosine | 2017 |
Characterization and application studies of ProxyPhos, a chemosensor for the detection of proximally phosphorylated peptides and proteins in aqueous solutions.
Topics: Fluorescent Dyes; Peptides; Phosphorylation; Proteins; Serine; Spectrometry, Fluorescence; Threonine; Tyrosine | 2017 |
iMulti-HumPhos: a multi-label classifier for identifying human phosphorylated proteins using multiple kernel learning based support vector machines.
Topics: Benchmarking; Computational Biology; Datasets as Topic; Humans; Internet; Phosphorylation; Protein Processing, Post-Translational; Proteins; Serine; Software; Support Vector Machine; Threonine; Tyrosine | 2017 |
Dietary methionine source and level affect hepatic sulfur amino acid metabolism of broiler breeder hens.
Topics: Adenosine Deaminase; Alanine; Amino Acids, Sulfur; Animals; Butyrates; Chickens; Diet; Dietary Supplements; Female; Gene Expression; Glycine; Liver; Methionine; Methionine Adenosyltransferase; Serine; Tyrosine; Valine | 2017 |
Topics: Amino Acids; Anaplasma phagocytophilum; Anaplasmosis; Animals; Apoptosis; Bacterial Proteins; Carbohydrate Metabolism; Cell Line; Citric Acid Cycle; Genome, Bacterial; Gluconeogenesis; Glycolysis; Host-Pathogen Interactions; Ixodes; Metabolic Networks and Pathways; Mitochondria; Oxaloacetic Acid; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxykinase (ATP); Proteomics; RNA, Messenger; Serine; Transcriptome; Tyrosine | 2017 |
FPD: A comprehensive phosphorylation database in fungi.
Topics: Animals; Databases, Factual; Fungal Proteins; Fungi; Humans; Phosphorylation; Plants; Protein Processing, Post-Translational; Serine; Threonine; Tyrosine | 2017 |
Prediction of phosphorylation sites based on Krawtchouk image moments.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Area Under Curve; Computational Biology; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; ROC Curve; Serine; Support Vector Machine; Threonine; Tyrosine | 2017 |
STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line, Tumor; Female; HEK293 Cells; Humans; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-beta; Kynurenine; MCF-7 Cells; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Phosphorylation; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Serine; Signal Transduction; STAT3 Transcription Factor; Tumor Suppressor Protein p53; Tyrosine | 2018 |
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.
Topics: alpha-Synuclein; Autopsy; Binding Sites; Brain; Humans; Parkinson Disease; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Serine; Single-Domain Antibodies; Tyrosine | 2018 |
Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation.
Topics: Binding Sites; Crystallography, X-Ray; Harmine; Humans; Models, Molecular; Molecular Docking Simulation; Phosphorylation; Protein Serine-Threonine Kinases; Protein Stability; Protein Structure, Secondary; Protein-Tyrosine Kinases; Serine; Tyrosine | 2018 |
Endoplasmic reticulum stress induces spatial memory deficits by activating GSK-3.
Topics: Activating Transcription Factor 6; Alzheimer Disease; Animals; Brain; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Stress; Glycogen Synthase Kinase 3; Male; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Serine; Spatial Memory; Tunicamycin; Tyrosine; Unfolded Protein Response | 2018 |
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Male; Middle Aged; Phosphorylation; Psychiatric Status Rating Scales; Serine; Statistics, Nonparametric; tau Proteins; Threonine; Tyrosine | 2018 |
Toxoplasma gondii stabilises tetrameric complexes of tyrosine-phosphorylated signal transducer and activator of transcription-1 and leads to its sustained and promiscuous DNA binding.
Topics: Animals; Cell Nucleus; DNA; Host-Parasite Interactions; Interferon-gamma; Mice; Oligonucleotides; Phosphorylation; Protein Multimerization; Protozoan Proteins; RAW 264.7 Cells; Serine; STAT1 Transcription Factor; Toxoplasma; Toxoplasmosis; Tyrosine | 2018 |
Conditional accumulation of toxic tRNAs to cause amino acid misincorporation.
Topics: Amino Acid Substitution; Anticodon; Protein Biosynthesis; RNA Stability; RNA, Transfer, Ser; RNA, Transfer, Tyr; Saccharomyces cerevisiae; Serine; Tyrosine | 2018 |
AMBER and CHARMM Force Fields Inconsistently Portray the Microscopic Details of Phosphorylation.
Topics: Hydrogen Bonding; Molecular Dynamics Simulation; Phosphorylation; Protein Conformation; Serine; Threonine; Tyrosine | 2019 |
The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Cardiomyopathy, Hypertrophic; Carrier Proteins; Male; Mice; Mice, 129 Strain; Mice, Knockout; Mutant Proteins; Mutation, Missense; Myocardial Contraction; Myocardium; Protein Domains; Sarcomeres; Serine; Tyrosine | 2019 |
Structure of a serine-type glutathione S-transferase of Ceriporiopsis subvermispora and identification of the enzymatically important non-canonical residues by functional mutagenesis.
Topics: Amino Acids; Asparagine; Coriolaceae; Crystallography, X-Ray; Fungal Proteins; Glutathione; Glutathione Transferase; Ligands; Mutagenesis; Serine; Tyrosine | 2019 |
A chemoenzymatic approach enables the site-specific conjugation of recombinant proteins.
Topics: Aldehydes; Biotechnology; Endopeptidases; Hydrazones; Immobilized Proteins; Phosphopeptides; Recombinant Proteins; Serine; Tyrosine | 2019 |
Genetic code ambiguity modulates the activity of a C. albicans MAP kinase linked to cell wall remodeling.
Topics: Candida albicans; Cell Wall; Fungal Proteins; Genetic Code; Leucine; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Biosynthesis; Serine; Signal Transduction; Tyrosine; Virulence | 2019 |
L-Tyr-Induced Phosphorylation of Tyrosine Hydroxylase at Ser40: An Alternative Route for Dopamine Synthesis and Modulation of Na+/K+-ATPase in Kidney Cells.
Topics: Animals; Cell Line; Dopa Decarboxylase; Dopamine; Kidney; Phosphorylation; Receptors, Dopamine D1; Serine; Sodium-Potassium-Exchanging ATPase; Swine; Tyrosine; Tyrosine 3-Monooxygenase | 2019 |
Efficient Building Blocks for Solid-Phase Peptide Synthesis of Spin Labeled Peptides for Electron Paramagnetic Resonance and Dynamic Nuclear Polarization Applications.
Topics: Amino Acids; Electron Spin Resonance Spectroscopy; Fluorenes; Hydroxyproline; Oligopeptides; Proton Magnetic Resonance Spectroscopy; Pyrrolidines; Serine; Solid-Phase Synthesis Techniques; Spin Labels; Tyrosine | 2019 |
Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Coumarins; Drug Discovery; Fluorescence; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Docking Simulation; Phosphorylation; Reactive Oxygen Species; Serine; STAT3 Transcription Factor; Thiophenes; Tyrosine | 2019 |
Redox-Dependent Metastability of the Nitrogenase P-Cluster.
Topics: Azotobacter vinelandii; Bacterial Proteins; Gluconacetobacter; Iron-Sulfur Proteins; Mutation; Nitrogenase; Oxidation-Reduction; Protein Conformation; Protein Stability; Serine; Tyrosine | 2019 |
Covalent Labeling with Diethylpyrocarbonate: Sensitive to the Residue Microenvironment, Providing Improved Analysis of Protein Higher Order Structure by Mass Spectrometry.
Topics: beta 2-Microglobulin; Diethyl Pyrocarbonate; Human Growth Hormone; Humans; Mass Spectrometry; Peptide Fragments; Protein Conformation; Serine; Threonine; Tyrosine; Ubiquitin | 2019 |
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures.
Topics: Cytosol; Enterobacteriaceae Infections; Enteropathogenic Escherichia coli; HeLa Cells; Humans; Molecular Weight; NF-kappa B; Phosphorylation; Receptor-Interacting Protein Serine-Threonine Kinase 2; Serine; Shigella flexneri; Signal Transduction; Tyrosine; Ubiquitination; X-Linked Inhibitor of Apoptosis Protein | 2019 |
Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb.
Topics: Humans; Phosphorylation; Positive Transcriptional Elongation Factor B; Protein Processing, Post-Translational; RNA Polymerase II; Serine; Transcription, Genetic; Tyrosine | 2019 |
Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Topics: Amino Acid Substitution; Amino Acids; Carrier Proteins; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cysteine; Enzyme Inhibitors; Humans; Isoenzymes; Ligands; Membrane Proteins; Models, Molecular; Mutant Proteins; Phosphoenolpyruvate; Protein Binding; Protein Conformation; Serine; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Tyrosine | 2019 |
Boosting phosphorylation site prediction with sequence feature-based machine learning.
Topics: Algorithms; Animals; Binding Sites; Computational Biology; Databases, Protein; Humans; Machine Learning; Models, Molecular; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Proteins; Reproducibility of Results; Sequence Analysis, Protein; Serine; Species Specificity; Threonine; Tyrosine | 2020 |
Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.
Topics: Cell Cycle Proteins; Fragile X Mental Retardation Protein; Humans; Nuclear Magnetic Resonance, Biomolecular; Phase Transition; Phosphorylation; Polyadenylation; Protein Biosynthesis; RNA, Messenger; Serine; Signal Transduction; Threonine; Tyrosine | 2019 |
Phospho-Ser727 triggers a multistep inactivation of STAT3 by rapid dissociation of pY705-SH2 through C-terminal tail modulation.
Topics: Cells, Cultured; HEK293 Cells; Hep G2 Cells; Humans; Phosphorylation; Serine; src Homology Domains; STAT3 Transcription Factor; Tyrosine | 2020 |
Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range.
Topics: Amino Acids; Hydrogen-Ion Concentration; Intrinsically Disordered Proteins; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Protein Structure, Secondary; Serine; Temperature; Threonine; Tyrosine | 2019 |
Silk sericin intake leads to increases in L-serine and L-tyrosine levels in the mouse brain and the simultaneous facilitation of brain noradrenergic turnover.
Topics: Animals; Brain; Male; Metallothionein 3; Mice; Mice, Inbred C57BL; Norepinephrine; Sericins; Serine; Silk; Tyrosine | 2020 |
Syntheses of Atypically Fluorinated Peptidyl Macrocycles through Sequential Vinylic Substitutions.
Topics: Cysteine; Histidine; Humans; Macrocyclic Compounds; Peptides; Serine; Tyrosine; Vinyl Compounds | 2020 |
The tyrosine 73 and serine 83 dephosphorylation of H1N1 swine influenza virus NS1 protein attenuates virus replication and induces high levels of beta interferon.
Topics: Animals; Cytokines; Dogs; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunologic Factors; Influenza A Virus, H1N1 Subtype; Interferon-beta; Madin Darby Canine Kidney Cells; Mutant Proteins; Phosphorylation; Protein Processing, Post-Translational; Serine; Tyrosine; Viral Nonstructural Proteins; Virulence Factors; Virus Replication | 2019 |
Regulation of PTP1B activation through disruption of redox-complex formation.
Topics: 14-3-3 Proteins; Biotinylation; Enzyme Activation; ErbB Receptors; HEK293 Cells; Humans; Oxidation-Reduction; Phosphorylation; Protein Interaction Maps; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Reactive Oxygen Species; Serine; Tyrosine | 2020 |
Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancer.
Topics: Benzophenanthridines; Cell Line, Tumor; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoquinolines; Phosphorylation; Protein Binding; Serine; STAT3 Transcription Factor; Triple Negative Breast Neoplasms; Tyrosine | 2020 |
Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression.
Topics: Adolescent; Autonomic Nervous System; Depression; Fatigue; Female; Glycine; Heart Rate; Humans; Metabolomics; Monitoring, Physiologic; Pyrimidines; Serine; Steroids; Stress, Physiological; Students; Threonine; Tyrosine; Ubiquinone; Urine; Young Adult | 2020 |
Nonclassical nuclear localization signals mediate nuclear import of CIRBP.
Topics: Active Transport, Cell Nucleus; Arginine; beta Karyopherins; Cell Nucleus; Cytoplasm; Glycine; HeLa Cells; Humans; Nuclear Localization Signals; Peptide Fragments; Protein Binding; Protein Conformation; RNA-Binding Proteins; Serine; Tyrosine | 2020 |
Immunolocalization of corneous proteins including a serine-tyrosine-rich beta-protein in the adhesive pads in the tokay gecko.
Topics: Animals; beta-Keratins; Epidermis; Foot; Lipid Metabolism; Lizards; Proteins; Serine; Tyrosine | 2020 |
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Animals; Female; Humans; Lewy Body Disease; Male; Mice; Phosphorylation; Protein Processing, Post-Translational; Serine; Tyrosine | 2020 |
Binding interaction of allethrin with esterase: Bioremediation potential and mechanism.
Topics: Alanine; Allethrins; Arginine; Biodegradation, Environmental; Esterases; Glutamates; Histidine; Leucine; Lysine; Methionine; Pseudomonas; Serine; Tyrosine | 2020 |
Improved GROMOS 54A7 Charge Sets for Phosphorylated Tyr, Ser, and Thr to Deal with pH-Dependent Binding Phenomena.
Topics: Binding Sites; Hydrogen-Ion Concentration; Molecular Dynamics Simulation; Phosphorylation; Serine; Threonine; Tyrosine | 2020 |
Intracellular Ser/Thr/Tyr phosphoproteome of the oral commensal Streptococcus gordonii DL1.
Topics: Bacterial Proteins; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Humans; Mouth; Phosphoproteins; Phosphorylation; Serine; Streptococcus gordonii; Tandem Mass Spectrometry; Threonine; Tyrosine | 2020 |
DeepPPSite: A deep learning-based model for analysis and prediction of phosphorylation sites using efficient sequence information.
Topics: Amino Acid Sequence; Animals; Computational Biology; Databases, Protein; Deep Learning; Models, Statistical; Phosphorylation; Protein Processing, Post-Translational; ROC Curve; Sequence Analysis, Protein; Serine; Threonine; Tyrosine | 2021 |
An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation.
Topics: ADP-Ribosylation; Amino Acid Sequence; Antibodies; Benzimidazoles; Carrier Proteins; Cell Line, Tumor; Cell Surface Display Techniques; DNA Damage; Glycoside Hydrolases; Histones; Humans; Nuclear Proteins; Phosphates; Phosphoric Monoester Hydrolases; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Recombinant Proteins; Serine; Tyrosine | 2020 |
Exploring the structural significance of molecular switch mechanism alias motif phosphorylation in Wnt/β-catenin and their crucial role in triple-negative breast cancer.
Topics: beta Catenin; Humans; Molecular Dynamics Simulation; Phosphorylation; Protein Conformation; Protein Domains; Protein Processing, Post-Translational; Serine; Tyrosine | 2021 |
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Topics: Amino Acid Motifs; Autoantigens; HEK293 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Naphthyridines; Phosphorylation; Protein Binding; Protein Biosynthesis; Ribonucleoproteins; Serine; Sirolimus; SS-B Antigen; Threonine; Tyrosine | 2021 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models, Animal; Enzyme Activation; Glucose Transporter Type 4; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphorylation; Plant Extracts; Rats; Rosmarinus; Serine; TOR Serine-Threonine Kinases; Tyrosine | 2021 |
Composition of Amino Acids in Foodstuffs for Humans and Animals.
Topics: Amino Acids; Animals; Humans; Isoleucine; Leucine; Methionine; Serine; Swine; Threonine; Tyrosine | 2021 |
Extensive regulation of enzyme activity by phosphorylation in Escherichia coli.
Topics: Binding Sites; Enzymes; Escherichia coli; Escherichia coli Proteins; Mass Spectrometry; Metabolomics; Mutation; Phosphorylation; Protein Processing, Post-Translational; Proteome; Proteomics; Serine; Threonine; Tyrosine | 2021 |
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Amino Acid Substitution; Autopsy; Brain; Casein Kinase II; Cells, Cultured; Female; Humans; Lewy Body Disease; Male; Mutation; Phosphorylation; Serine; Tyrosine | 2021 |
Discerning Tyrosine Phosphorylation from Multiple Phosphorylations Using a Nanofluidic Logic Platform.
Topics: Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Serine; Threonine; Tyrosine | 2021 |
Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells.
Topics: Apoptosis; Benzophenanthridines; Berberine Alkaloids; Cell Line, Tumor; Humans; Interleukin-6; Melanoma; Microtubules; Phosphorylation; Serine; Signal Transduction; STAT3 Transcription Factor; Tyrosine; Uveal Neoplasms | 2021 |
Clostridioides difficile Phosphoproteomics Shows an Expansion of Phosphorylated Proteins in Stationary Growth Phase.
Topics: Clostridioides; Clostridioides difficile; Serine; Threonine; Tyrosine | 2022 |
Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system.
Topics: Animals; Aromatase; Central Nervous System; Estrogen Receptor alpha; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Rats; Serine; Tyrosine | 2022 |
Comprehensively understanding metabolic pathways of protein during the anaerobic digestion of waste activated sludge.
Topics: Acetyl Coenzyme A; Alanine; Amino Acids; Anaerobiosis; Arginine; Glutamates; Glycine; Histidine; Leucine; Lysine; Metabolic Networks and Pathways; Methionine; Phenylalanine; Pyruvic Acid; Serine; Sewage; Threonine; Tyrosine | 2022 |
Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome.
Topics: Angelica sinensis; Animals; Drugs, Chinese Herbal; Fatigue Syndrome, Chronic; Glycine; Metabolomics; Rats; Serine; Threonine; Tyrosine | 2022 |
Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Topics: Adenosine Triphosphate; Animals; Catalysis; Racemases and Epimerases; Serine; Tyrosine | 2022 |
Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway.
Topics: Berberine; Humans; Insulin; Insulin Resistance; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Molecular Docking Simulation; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Tumor Necrosis Factor-alpha; Tyrosine | 2022 |
STAT3 suppresses the AMPKα/ULK1-dependent induction of autophagy in glioblastoma cells.
Topics: AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Glioblastoma; Humans; Intracellular Signaling Peptides and Proteins; Phosphorylation; Serine; STAT3 Transcription Factor; Tyrosine | 2022 |
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.
Topics: ADP-Ribosylation; Animals; Histones; Rats; Resveratrol; Serine; Tyrosine; Tyrosine-tRNA Ligase | 2022 |
Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer.
Topics: Cell Line, Tumor; Humans; Phenotype; Phosphorylation; Serine; STAT3 Transcription Factor; Triple Negative Breast Neoplasms; Tyrosine | 2022 |
The amino acid profile of Camelina sativa seeds correlates with the strongest immune response in dairy ewes.
Topics: Amino Acids; Animal Feed; Animals; Brassicaceae; Diet; Fatty Acids; Fatty Acids, Unsaturated; Female; Immunity, Innate; Interferon Regulatory Factors; Interferon-beta; Interleukin-10; Interleukin-1beta; Interleukin-8; Lysine; Mitogen-Activated Protein Kinases; Seeds; Serine; Sheep; Threonine; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Tyrosine | 2022 |
The combination of microbiome and metabolome to analyze the cross-cooperation mechanism of
Topics: Alanine; Animals; Echinacea; Fatty Acids, Volatile; Gastrointestinal Microbiome; Glycine; Glycosphingolipids; Humans; Leucine; Metabolome; Mice; Microbiota; Ornithine; Phenylalanine; Polysaccharides; Porphyrins; Serine; Threonine; Tryptophan; Tyrosine | 2022 |
HM-Chromanone, a Major Homoisoflavonoid in
Topics: Glucose; Glucose Transporter Type 4; Glycogen; Glycogen Synthase Kinase 3; Humans; I-kappa B Kinase; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoflavones; JNK Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Muscle, Skeletal; Palmitates; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphorylation; Portulaca; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Serine; Tyrosine | 2022 |
[Determination of free amino acids in Eriocheir sinensis by ultra-high performance liquid chromatography-high resolution mass spectrometry].
Topics: Acetonitriles; Alanine; Amino Acids; Animals; Arginine; Aspartic Acid; Brachyura; Chromatography, High Pressure Liquid; Cystine; Formates; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Mass Spectrometry; Methionine; Perchlorates; Phenylalanine; Polypropylenes; Proline; Serine; Solvents; Threonine; Tyrosine; Valine; Water | 2022 |
DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Receptor-Interacting Protein Serine-Threonine Kinases; Serine; T-Lymphocytes; Threonine; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Tyrosine | 2022 |
Inhibition of 26S proteasome enhances AKAP3-mediated cAMP-PKA signaling during boar sperm capacitation.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Male; Phosphorylation; Proteasome Endopeptidase Complex; Semen; Serine; Sperm Capacitation; Spermatozoa; Swine; Threonine; Tyrosine; Ubiquitins | 2022 |
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
Topics: Adipocytes; Animals; Diabetes Mellitus, Type 2; Homeostasis; Insulin; Insulin Resistance; Male; Mice; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Serine; Threonine; Tyrosine | 2022 |
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
Topics: Adipocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mechanistic Target of Rapamycin Complex 1; Phosphoproteins; Pyruvaldehyde; Serine; Signal Transduction; Tyrosine | 2022 |
Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns.
Topics: Alanine; Amino Acids; Animals; Antihypertensive Agents; Antioxidants; Aspartic Acid; Cucurbitaceae; Glycine; Hypertension; Phenylalanine; Plant Extracts; Rats; Rats, Inbred Dahl; Renal Insufficiency; Serine; Sodium Chloride; Sodium Chloride, Dietary; Threonine; Tyrosine | 2022 |
Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation.
Topics: Animals; Apoptosis; Inflammation; Mice; Phosphorylation; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 2022 |
Dissecting the potential mechanism of antihypertensive effects of RVPSL on spontaneously hypertensive rats via widely targeted kidney metabolomics.
Topics: 3-Hydroxybutyric Acid; Animals; Antihypertensive Agents; Arachidonic Acid; Biomarkers; Blood Pressure; Carbon; Citric Acid; Hypertension; Kidney; Metabolomics; Rats; Rats, Inbred SHR; Serine; Thyronines; Tyramine; Tyrosine | 2023 |
Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Topics: Animals; Cardiomegaly; Cardiomyopathy, Hypertrophic; Mice; Phosphorylation; Proteome; Serine; Threonine; Tyrosine | 2022 |
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
Topics: alpha-Synuclein; Animals; Humans; Mice; Mice, Transgenic; Mutation; Neurotoxicity Syndromes; Phenylalanine; Serine; Tyrosine | 2022 |
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.
Topics: Autophagic Cell Death; Ciclopirox; Humans; Phosphorylation; Serine; STAT3 Transcription Factor; Stomach Neoplasms; Tyrosine | 2022 |
Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases.
Topics: Molecular Dynamics Simulation; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Serine; Threonine; Tyrosine | 2022 |
Metabolic pathway analysis of hyperuricaemia patients with hyperlipidaemia based on high-throughput mass spectrometry: a case‒control study.
Topics: Alanine; Aspartic Acid; Biomarkers; Case-Control Studies; Glycine; Humans; Hyperlipidemias; Hyperuricemia; Linoleic Acid; Mass Spectrometry; Metabolic Diseases; Metabolic Networks and Pathways; Phenylalanine; Serine; Threonine; Tryptophan; Tyrosine | 2022 |
Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia.
Topics: Animals; Apoptosis; Cell Line, Tumor; Dasatinib; DNA; DNA-Activated Protein Kinase; Leukemia, Myeloid, Acute; Mice; Mutation; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; Serine; Signal Transduction; Threonine; TOR Serine-Threonine Kinases; Tyrosine | 2023 |
Embryonic poly(A)-binding protein interacts with translation-related proteins and undergoes phosphorylation on the serine, threonine, and tyrosine residues in the mouse oocytes and early embryos.
Topics: Animals; Humans; Mice; Oocytes; Phosphorylation; Poly(A)-Binding Proteins; Serine; Threonine; Tyrosine | 2023 |
Metabolomics profiling of seminal plasma in obesity-induced asthenozoospermia.
Topics: Aconitic Acid; Alanine; Asthenozoospermia; Citrulline; Glucose; Glutamic Acid; Glycine; Humans; Leucine; Lysine; Male; Metabolomics; Phenylalanine; Proline; Semen; Serine; Succinic Acid; Threonine; Tyrosine; Valine | 2023 |
Standardized ileal digestibility of amino acids in cottonseed meal fed to pregnant and non-pregnant sows.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Aspartic Acid; Cottonseed Oil; Cysteine; Diet; Digestion; Female; Glycine max; Ileum; Methionine; Pregnancy; Serine; Swine; Threonine; Tyrosine | 2023 |
Effect of Photobiomodulation on Protein Kinase Cδ, Cytochrome C, and Mitochondria in U87 MG Cells.
Topics: Cytochromes c; Humans; Low-Level Light Therapy; Mitochondria; Protein Kinase C-delta; Serine; Tyrosine | 2023 |
Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Hippocampus; Humans; Mice; Neurons; Phosphorylation; Protein Tyrosine Phosphatases; Receptors, Nicotinic; Serine; Threonine; Tyrosine | 2023 |
Detection and identification of amino acids and proteins using their intrinsic fluorescence in the visible light spectrum.
Topics: Alanine; Amino Acids; Arginine; Cystine; Fluorescence; Glycine; Leucine; Methionine; Proteins; Serine; Threonine; Tyrosine; Valine | 2023 |