Compounds > serine

serine and tamoxifen

serine has been researched along with tamoxifen in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.33)18.7374
1990's3 (6.98)18.2507
2000's20 (46.51)29.6817
2010's17 (39.53)24.3611
2020's2 (4.65)2.80

Authors

AuthorsStudies
Bolan, G; Lippman, M; Monaco, ME1
Chambon, P; Endoh, H; Gotoh, Y; Kato, S; Kawashima, H; Kitamoto, T; Masuhiro, Y; Masushige, S; Metzger, D; Nishida, E; Sasaki, H; Uchiyama, S1
Ali, S; Bornert, JM; Chambon, P; Metzger, D1
Enmark, E; Gustafsson, JA; Katzenellenbogen, BS; Kushner, PJ; Kwok, GR; Lopez, GN; McInerney, E; Nguyen, P; Nilsson, S; Valentine, C; Webb, P1
Ali, S; Bhat-Nakshatri, P; Campbell, RA; Constantinidou, D; Nakshatri, H; Patel, NM1
Feng, W; Karin, M; Kushner, PJ; Li, J; Liu, X; Nguyen, P; Webb, P1
Greenberg, AS; Kraemer, FB; Muliro, K; Patel, S; Roth, RA; Shen, WJ; Souza, SC1
Coulombe, P; Di Marcotullio, L; Draetta, GF; Meloche, S; Montagnoli, A; Pagano, M; Rodier, G1
Ali, S; Bates, GJ; Chen, D; Coombes, RC; Egly, JM; Epstein, RJ; Fuller-Pace, FV; Pace, PE; Sarwar, N; Taylor, J; Thirunuvakkarasu, V; Washbrook, E1
Kataoka, K; Nishizawa, M; Vogt, PK1
Auberger, P; Cagnol, S; Colosetti, P; Herrant, M; Jacquel, A; Luciano, F; Pages, G1
Balkenende, A; Floore, A; Griekspoor, A; Jalink, K; Janssen, L; Michalides, R; Neefjes, J; van't Veer, L; Velds, A; Verwoerd, D1
Murphy, LC; Niu, Y; Snell, L; Watson, P1
Rowan, BG; Shah, YM1
Bhatnagar, S; Blankenship, KA; Brey, DM; Keynton, RS; Klinge, CM; Noisin, EL; Risinger, KE; Sumanasekera, WK; Zhao, L1
Aldaz, CM; Balasenthil, S; Barnes, CJ; Khan, S; Kumar, R; Rayala, SK; Talukder, AH; Tharakan, R; Wang, RA1
Atanaskova, N; Glaros, S; Reddy, KB; Skafar, DF; Zhao, C1
Jordan, VC1
Kumar, R; Rayala, SK1
Band, H; Cook, SJ; Wiggins, CM1
Andre, F; Bouaziz, J; Corley, L; Delaloge, S; Drusche, F; Geha, S; Liedtke, C; Mathieu, MC; Mazouni, C; Spielmann, M; Symmans, WF; Zoubir, M1
Fles, R; Hauptmann, M; Holm, C; Kok, M; Koornstra, RH; Landberg, G; Linn, SC; Michalides, R; Neefjes, J; Peterse, JL; Stål, O; Wesseling, J1
Ando, S; Barone, I; Berno, V; Cui, Y; Fuqua, SA; Giordano, C; Mancini, MA1
Heveker, N; Lepage, J; Sanchez, M; Sauvé, K; Tremblay, A1
Cheng, JQ; Coppola, D; Esposito, NN; Guo, JP; Koomen, JM; Shu, SK1
Hauptmann, M; Holm-Wigerup, C; Kok, M; Landberg, G; Linn, S; Michalides, R; Stål, O1
Byrne, C; Donley, C; Hirst, DG; Jithesh, PV; McCarthy, HO; McKeen, HD; O'Rourke, M; Robson, T; Swanton, C; Valentine, A; Yakkundi, A1
Bostner, J; Fornander, T; Nordenskjöld, B; Skoog, L; Stål, O1
Fles, R; Hauptmann, M; Holm, C; Kok, M; Landberg, G; Linn, SC; Michalides, R; Neefjes, J; Stål, O; Van't Veer, LJ; Wessels, LF; Zwart, W1
Inaji, H; Ishitobi, M; Komoike, Y; Koyama, H; Motomura, K; Nagase, H; Noguchi, S1
Gritsch, D; Komina, O; Maurer, M; Węsierska-Gądek, J; Zulehner, N1
de Leeuw, R; Houtman, R; Martens, JW; Melchers, D; Michalides, R; Neefjes, J; Rondaij, M; Ruijtenbeek, R; Verwoerd, D1
Baldwin, MA; Benz, CC; Britton, DJ; Gibson, BW; Held, JM; Lee, EL; Schilling, B; Scott, GK1
Bostner, J; Fornander, T; Karlsson, E; Nordenskjöld, B; Pandiyan, MJ; Skoog, L; Stål, O; Westman, H1
Brychtova, V; Fabian, P; Hrstka, R; Hupp, TR; Murray, E; Vojtesek, B1
Boska, MD; Dunaevsky, A; Padmashri, R; Suresh, A1
Abdel-Fatah, TM; Ali, S; Canisius, S; Carroll, JS; Chan, S; Coombes, RC; Droog, M; Ellis, IO; Flach, KD; Gojis, O; Hofland, I; Moore, D; Nevedomskaya, E; Opdam, M; Palmieri, C; Rudraraju, B; Shaw, J; Zwart, W1
Alayev, A; Berger, SM; Cuesta, R; Holz, MK; Salamon, RS; Schwartz, NS; Snyder, RB1
Bezzi, P; Bischofberger, J; Cassé, F; Gebara, E; Li, L; Lopatar, J; Moss, J; Petrelli, F; Pfrieger, FW; Sultan, S; Toni, N1
Ali, S; Buluwela, L; Castellano, L; Coombes, RC; de Giorgio, A; Fulton, J; Gomez, PJ; Harrod, A; Lai, CF; Lin, ML; Magnani, L; Metodiev, MV; Metodieva, G; Nguyen, VTM; Periyasamy, M; Ramos-Garcia, L; Santos, DB; Stebbing, J; Williams, RL1
Gordon, B; Kastrati, I; Semina, S; Smart, E1
Clem, BF; Dougherty, S; Green, B; Klinge, CM; Kruer, T; Metcalf, S; Petri, BJ; Wittliff, JL1
Barker, O; Boyd, C; Feutren-Burton, S; Gavory, G; Gibson, H; Harrison, T; Jordan, L; McLean, E; O'Dowd, CR; O'Rourke, M; Page, N; Rountree, JSS; Trevitt, G; Wappett, M; Zhang, L1

Reviews

2 review(s) available for serine and tamoxifen

ArticleYear
Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2007, Volume: 61, Issue:7

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Nucleus; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; p21-Activated Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Tamoxifen

2007
Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer.
    Molecular and cellular endocrinology, 2019, 03-01, Volume: 483

    Topics: Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Receptors, Estrogen; Serine; Tamoxifen

2019

Trials

4 trial(s) available for serine and tamoxifen

ArticleYear
Estrogen receptor-alpha phosphorylation at serine-118 and tamoxifen response in breast cancer.
    Journal of the National Cancer Institute, 2009, Dec-16, Volume: 101, Issue:24

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Multivariate Analysis; Odds Ratio; Phosphorylation; Premenopause; Proportional Hazards Models; Serine; Tamoxifen

2009
Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Mar-01, Volume: 16, Issue:5

    Topics: Breast Neoplasms; Cell Nucleus; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Profiling; Humans; Immunohistochemistry; Middle Aged; p21-Activated Kinases; Phosphorylation; Postmenopause; Prognosis; Selective Estrogen Receptor Modulators; Serine; Tamoxifen; Tissue Array Analysis

2010
PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer.
    Breast cancer research and treatment, 2011, Volume: 125, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Chemotherapy, Adjuvant; Cyclic AMP-Dependent Protein Kinases; Disease-Free Survival; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Estrogen Receptor Modulators; Europe; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; p21-Activated Kinases; Patient Selection; Phosphorylation; Predictive Value of Tests; Proportional Hazards Models; Reproducibility of Results; Risk Assessment; Risk Factors; Serine; Tamoxifen; Time Factors; Tissue Array Analysis; Transfection; Treatment Outcome; Up-Regulation

2011
Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit.
    Breast cancer research and treatment, 2013, Volume: 137, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Middle Aged; Phosphorylation; Postmenopause; Predictive Value of Tests; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Retrospective Studies; Serine; Tamoxifen; TOR Serine-Threonine Kinases; Treatment Outcome

2013

Other Studies

37 other study(ies) available for serine and tamoxifen

ArticleYear
Effects of estrone, estradiol, and estriol on hormone-responsive human breast cancer in long-term tissue culture.
    Cancer research, 1977, Volume: 37, Issue:6

    Topics: Binding, Competitive; Breast Neoplasms; Cell Nucleus; Culture Techniques; Cytoplasm; Drug Interactions; Estradiol; Estriol; Estrone; Humans; Receptors, Estrogen; Serine; Tamoxifen; Thymidine

1977
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase.
    Science (New York, N.Y.), 1995, Dec-01, Volume: 270, Issue:5241

    Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Humans; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; Phosphorylation; Polyunsaturated Alkamides; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Receptors, Estrogen; Recombinant Fusion Proteins; Serine; Somatomedins; Tamoxifen; Transcriptional Activation; Transfection

1995
Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.
    The EMBO journal, 1993, Volume: 12, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Estradiol; Estrogen Antagonists; Humans; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Polyunsaturated Alkamides; Receptors, Estrogen; Sequence Deletion; Serine; Tamoxifen; Transcription, Genetic

1993
The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:10

    Topics: Binding Sites; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; HeLa Cells; Humans; Phenotype; Receptors, Estrogen; Recombinant Proteins; Response Elements; Selective Estrogen Receptor Modulators; Sequence Deletion; Serine; Tamoxifen; Transcription Factor AP-1; Transcriptional Activation

1999
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Division; Cell Survival; Chloramphenicol O-Acetyltransferase; Chromones; COS Cells; Cytokines; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Growth Differentiation Factor 15; Humans; Models, Biological; Morpholines; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; Plasmids; Precipitin Tests; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Receptors, Estrogen; Serine; Signal Transduction; Tamoxifen; Time Factors; Transfection; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins; Up-Regulation

2001
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:1

    Topics: CREB-Binding Protein; Drug Synergism; Enzyme Activation; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nuclear Proteins; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivators; Oncogene Protein pp60(v-src); Phosphorylation; Protein-Tyrosine Kinases; Proteins; Receptors, Estrogen; Response Elements; Serine; Signal Transduction; Structure-Activity Relationship; Tamoxifen; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tyrosine; Vitellogenins

2001
Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: 3T3 Cells; Animals; Binding Sites; Cell Differentiation; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Isoproterenol; Lipolysis; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Plasmids; Serine; Signal Transduction; Sterol Esterase; Tamoxifen; Time Factors; Transfection

2001
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
    The EMBO journal, 2001, Dec-03, Volume: 20, Issue:23

    Topics: Alanine; Animals; Antifungal Agents; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Enzyme Activation; Estradiol; Estrogen Antagonists; Fatty Acids, Unsaturated; Fibroblasts; Immunoblotting; Microscopy, Fluorescence; Mutation; Phosphorylation; Protein Binding; Protein Transport; Rats; Serine; Tamoxifen; Time Factors; Transfection; Tumor Suppressor Proteins; Ubiquitin

2001
Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera.
    Oncogene, 2002, Jul-25, Volume: 21, Issue:32

    Topics: Amino Acid Sequence; Animals; Antibodies; Breast Neoplasms; COS Cells; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fulvestrant; Humans; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Estrogen; Serine; Signal Transduction; Tamoxifen

2002
MafA has strong cell transforming ability but is a weak transactivator.
    Oncogene, 2003, Sep-11, Volume: 22, Issue:39

    Topics: Amino Acid Sequence; Animals; Avian Proteins; Binding Sites; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chickens; Cloning, Molecular; Conserved Sequence; DNA; DNA-Binding Proteins; Estradiol; MafB Transcription Factor; Molecular Sequence Data; Mutation; Oncogene Proteins; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptors, Estrogen; Recombinant Proteins; Serine; Tamoxifen; Trans-Activators; Transcription Factors

2003
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
    Oncogene, 2003, Oct-02, Volume: 22, Issue:43

    Topics: Amino Acid Sequence; Antineoplastic Agents, Hormonal; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Binding Sites; Carrier Proteins; Caspases; Cell Line; Cell Survival; Cysteine Endopeptidases; Gene Expression Regulation; Glutathione Transferase; Humans; K562 Cells; Lymphoma; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Isoforms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Serine; Tamoxifen; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured

2003
Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.
    Cancer cell, 2004, Volume: 5, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Fluorescence Resonance Energy Transfer; Fulvestrant; Humans; Luciferases; Microscopy, Confocal; Models, Biological; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Conformation; Protein Structure, Tertiary; Receptors, Estrogen; RNA Interference; Serine; Tamoxifen; Time Factors; Transcriptional Activation; Transfection

2004
Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-01, Volume: 10, Issue:17

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; Female; Humans; Ligands; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Phosphorylation; Protein Binding; Receptors, Progesterone; Serine; Survival Rate; Tamoxifen; Treatment Outcome

2004
The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity.
    Molecular endocrinology (Baltimore, Md.), 2005, Volume: 19, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyclic AMP; Endometrial Neoplasms; Estradiol; Female; Genes, Dominant; Genes, Reporter; HeLa Cells; Histone Acetyltransferases; Humans; Luciferases; Models, Biological; Nuclear Receptor Coactivator 1; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Serine; src-Family Kinases; Tamoxifen; Time Factors; Transcription Factors; Transcription, Genetic

2005
Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Aorta; Blotting, Western; Cattle; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Flavonoids; Fulvestrant; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Microcirculation; Models, Biological; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenols; Phosphorylation; Polyphenols; Resveratrol; Serine; Signal Transduction; Stilbenes; Tamoxifen; Time Factors; Transfection; Umbilical Veins; Wine

2005
P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation.
    Cancer research, 2006, Feb-01, Volume: 66, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; HeLa Cells; Humans; p21-Activated Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Tamoxifen; Transcriptional Activation; Up-Regulation

2006
Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen.
    Molecular endocrinology (Baltimore, Md.), 2006, Volume: 20, Issue:5

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Green Fluorescent Proteins; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Proteins v-erbB; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Serine; Tamoxifen; Transfection

2006
Pak up your breast tumor--and grow!
    Journal of the National Cancer Institute, 2006, May-17, Volume: 98, Issue:10

    Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Recurrence, Local; p21-Activated Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Tamoxifen

2006
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
    Cellular signalling, 2007, Volume: 19, Issue:12

    Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Fibroblasts; Humans; Membrane Proteins; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Serine; Tamoxifen; Tyrosine; Ubiquitin; Vanadates

2007
Modulation of ER phosphorylation on serine 118 by endocrine therapy: a new surrogate marker for efficacy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:8

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; MAP Kinase Signaling System; Middle Aged; Phosphorylation; Receptor, IGF Type 1; Receptors, Estrogen; Serine; Tamoxifen

2008
Phosphorylation of the oestrogen receptor alpha at serine 305 and prediction of tamoxifen resistance in breast cancer.
    The Journal of pathology, 2009, Volume: 217, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Immunohistochemistry; Phosphorylation; Retrospective Studies; Serine; Tamoxifen; Tissue Array Analysis; Treatment Outcome

2009
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305.
    Breast cancer research and treatment, 2010, Volume: 119, Issue:1

    Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estrogen Receptor alpha; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Lysine; Mutation; Neuregulin-1; Phosphorylation; Serine; Signal Transduction; Tamoxifen; Time Factors

2010
Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway.
    Cancer research, 2009, Jul-15, Volume: 69, Issue:14

    Topics: Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Chemokine CXCL12; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Gene Expression Regulation, Neoplastic; Humans; Phosphorylation; Receptors, CXCR4; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Serine; Signal Transduction; Tamoxifen; Time Factors; Transcription Factor AP-1

2009
IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer.
    The Journal of biological chemistry, 2010, Feb-05, Volume: 285, Issue:6

    Topics: Amino Acid Substitution; Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; Cyclin D1; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Humans; I-kappa B Kinase; Immunoblotting; Phosphorylation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; Tamoxifen; Transcriptional Activation; Transfection

2010
FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.
    Cancer research, 2010, Feb-01, Volume: 70, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cathepsin D; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Estradiol; Estrogen Receptor alpha; Estrogens; Fulvestrant; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunophilins; Immunoprecipitation; Kaplan-Meier Estimate; Meta-Analysis as Topic; Phosphorylation; Protein Binding; RNA Interference; Serine; Signal Transduction; Tacrolimus Binding Proteins; Tamoxifen; Transfection

2010
Expression of estrogen receptor beta and phosphorylation of estrogen receptor alpha serine 167 correlate with progression-free survival in patients with metastatic breast cancer treated with aromatase inhibitors.
    Oncology, 2010, Volume: 79, Issue:1-2

    Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Estrogen Receptor alpha; Estrogen Receptor beta; Fadrozole; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Nitriles; Phosphorylation; Predictive Value of Tests; Prognosis; Retrospective Studies; Serine; Tamoxifen; Triazoles

2010
Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:4

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drug Synergism; Estrogen Receptor alpha; Flow Cytometry; G2 Phase; HeLa Cells; Humans; Immunoblotting; Membrane Potential, Mitochondrial; Phosphorylation; Protein Kinase Inhibitors; Purines; Roscovitine; Selective Estrogen Receptor Modulators; Serine; Tamoxifen; Time Factors

2011
Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:4

    Topics: Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Humans; Microarray Analysis; Osteosarcoma; Phosphorylation; Serine; Tamoxifen; Transfection

2012
Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.
    Molecular cancer research : MCR, 2012, Volume: 10, Issue:8

    Topics: Breast Neoplasms; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Estradiol; Estrogen Receptor alpha; Female; Humans; Ligands; MCF-7 Cells; Neoplasms, Hormone-Dependent; Phosphorylation; Serine; Tamoxifen; Transcriptional Activation

2012
Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2.
    Cancer letters, 2013, Jun-10, Volume: 333, Issue:2

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Antineoplastic Agents, Hormonal; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MicroRNAs; Molecular Sequence Data; Mucoproteins; Oncogene Proteins; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins c-akt; Ribonucleosides; Serine; Signal Transduction; Tamoxifen

2013
Motor-Skill Learning Is Dependent on Astrocytic Activity.
    Neural plasticity, 2015, Volume: 2015

    Topics: Animals; Antimetabolites; Astrocytes; Citrates; Estrogen Antagonists; Forelimb; In Vitro Techniques; Injections, Intraventricular; Inositol 1,4,5-Trisphosphate Receptors; Learning; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Motor Skills; Mutation; Psychomotor Performance; Receptors, AMPA; Serine; Synaptic Transmission; Tamoxifen

2015
SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Jan-15, Volume: 22, Issue:2

    Topics: Animals; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Chromatin; Cricetulus; Disease-Free Survival; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Nuclear Receptor Coactivator 3; Phosphorylation; Prognosis; Promoter Regions, Genetic; Serine; Tamoxifen

2016
mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.
    Oncogene, 2016, 07-07, Volume: 35, Issue:27

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Microscopy, Fluorescence; Multiprotein Complexes; Phosphorylation; Protein Binding; Regulatory-Associated Protein of mTOR; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; Signal Transduction; Tamoxifen; TOR Serine-Threonine Kinases

2016
Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.
    Neuron, 2015, Dec-02, Volume: 88, Issue:5

    Topics: Animals; Astrocytes; Clostridium botulinum type B; Dendritic Spines; Excitatory Amino Acid Transporter 1; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Hippocampus; Membrane Potentials; Mice; Mice, Transgenic; Neurogenesis; Neurons; Phosphopyruvate Hydratase; Receptors, N-Methyl-D-Aspartate; Serine; SNARE Proteins; Sodium Chloride; Synapses; Synaptic Transmission; Tamoxifen

2015
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
    Oncogene, 2017, 04-20, Volume: 36, Issue:16

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; CRISPR-Cas Systems; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Gene Knock-In Techniques; Histones; Humans; MCF-7 Cells; Mutation; Phosphorylation; Serine; Tamoxifen

2017
Serine synthesis influences tamoxifen response in ER+ human breast carcinoma.
    Endocrine-related cancer, 2021, Volume: 28, Issue:1

    Topics: Breast Neoplasms; Female; Humans; Serine; Tamoxifen; Transfection

2021
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.
    Scientific reports, 2022, 09-20, Volume: 12, Issue:1

    Topics: Angiogenesis Inhibitors; Humans; Isoenzymes; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Serine; Tamoxifen; Threonine

2022