serine has been researched along with sphingosine in 92 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (20.65) | 18.7374 |
| 1990's | 18 (19.57) | 18.2507 |
| 2000's | 32 (34.78) | 29.6817 |
| 2010's | 16 (17.39) | 24.3611 |
| 2020's | 7 (7.61) | 2.80 |
| Authors | Studies |
|---|---|
| Lev, M | 1 |
| Lev, M; Milford, AF | 2 |
| Krisnangkura, K; Sweeley, CC | 1 |
| Merrill, AH; Norred, WP; Riley, RT; Wang, E; Yoo, H | 1 |
| Kanfer, JN; Massarelli, R; Singh, IN; Sorrentino, G | 1 |
| Kanfer, JN; McCartney, D | 1 |
| Birk, R; Brenner-Weiss, G; Sandhoff, K; Schmidt, RR; van Echten, G | 1 |
| Merrill, AH; Messmer, TO; Stevens, VL; Wang, E | 1 |
| Bankov, I; Barrett, J | 1 |
| Merrill, AH; Wang, E | 1 |
| Medlock, KA; Merrill, AH | 2 |
| Hammond, RK; Sweeley, CC | 1 |
| Carter, TP; Kanfer, J | 1 |
| Sakagami, T; Taniguchi, M | 1 |
| Kanfer, JN; Kurtz, DJ | 1 |
| Barenholz, Y; Gadot, N; Gatt, S; Valk, E | 1 |
| Kanfer, JN; Sargent, A | 1 |
| Merrill, AH; Wang, E; Williams, RD | 1 |
| Radin, NS | 1 |
| Merrill, AH; Smith, ER | 1 |
| Ridgway, ND | 1 |
| Merriam, DL; Ridgway, ND | 1 |
| Terrian, DM; Ways, DK | 1 |
| Kanfer, JN; McCartney, DG | 1 |
| Allin, J; Ladenson, RC; Monsey, JD; Silbert, DF | 1 |
| Hamanoue, M; Inokuchi, J; Kohsaka, S; Usuki, S | 1 |
| Badiani, K; Byers, DM; Cook, HW; Ridgway, ND | 1 |
| Gillard, BK; Harrell, RG; Marcus, DM | 1 |
| Bär, T; Heinemann, T; Raths, A; Sandhoff, K; Schmidt, RR; van Echten-Deckert, G; Zschoche, A | 1 |
| Chigorno, V; Negroni, E; Nicolini, M; Sonnino, S | 1 |
| Futerman, AH; Giannis, A; Sandhoff, K; Schwarz, A; van Echten-Deckert, G | 1 |
| Fukuta, N; Kawate, T; Nakagawa, M; Nishida, A | 1 |
| Csaba, G; Hegyesi, H; Köhidai, L; Kovács, P; Nemes, P | 1 |
| Mao, C; Obeid, LM | 1 |
| Bokoch, GM; Dawson, PE; Dutil, EM; Hemmings, BA; King, CC; Newton, AC; Zenke, FT | 1 |
| Hanada, K; Hara, T; Nishijima, M | 1 |
| Azuma, H; Ogino, K; Tamagaki, S | 1 |
| Bodennec, J; Brichon, G; Koul, O; Portoukalian, J; Zwingelstein, G | 1 |
| Sadeghlar, F; Sandhoff, K; van Echten-Deckert, G | 1 |
| Lingwood, CA; Mylvaganam, M | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Bassi, R; Giussani, P; Riboni, L; Tettamanti, G; Viani, P | 1 |
| Brunk, UT; Eaton, JW; Neuzil, J | 1 |
| Igarashi, J; Michel, T | 1 |
| Hara-Nishimura, I; Imai, H; Mitsuhashi, N; Tamura, K | 1 |
| Benaud, C; Dickson, RB; Hobson, JP; Lin, CY; Oberst, M; Spiegel, S | 1 |
| Hashemzadeh, M; Howell, AR; Ndakala, AJ; So, RC | 1 |
| Facchini, A; Flamigni, F; Ghelli, A; Hrelia, S; Porcelli, AM; Rugolo, M | 1 |
| Anelli, V; Bassi, R; Brioschi, L; Giussani, P; Riboni, L; Tettamanti, G; Viani, P | 1 |
| Arthur, G; Bittman, R; Byun, HS; Chun, J | 1 |
| Azuma, H; Niiro, H; Ogino, K; Shikata, K; Tachibana, T; Takao, R; Tamagaki, S | 1 |
| Calderón, V; Reynoso, R; Salgado, LM | 1 |
| WEISS, B | 1 |
| FAILLARD, H; KLENK, E | 1 |
| Coen, K; De Jonghe, P; De Vriendt, E; Jacobs, A; Martin, JJ; Pou-Serradell, A; Smouts, I; Timmerman, V; Van Gerwen, V; Verhoeven, K | 1 |
| Guerrera, RL; Howell, AR; Izmirian, DP; Ndonye, R; Richardson, SK; So, RC | 1 |
| Bhaket, P; Datta, A; Morris, K; Stauffer, CS | 1 |
| Hercus, T; Lopez, A; Ma, Y; Murphy, J; Pitson, S; Woodcock, J | 1 |
| Cho, W; Hwang, JH; Johnson, KR; Kim, JH; Obeid, LM; Park, ZY; Stahelin, RV | 1 |
| Chigorno, V; Mikulak, J; Prinetti, A; Sciannamblo, M; Sonnino, S | 1 |
| Hakogi, T; Hasegawa, H; Katsumura, S; Yamamoto, T | 1 |
| Cowart, LA; Hannun, YA | 1 |
| Ham, WH; Joo, JE; Oh, CY; Pham, VT; Tian, YS | 1 |
| Liebeskind, LS; Yang, H | 1 |
| Fujii, S; Hayashi, H; Hoseki, J; Ikushiro, H; Islam, MM; Miyahara, I; Murakawa, T; Okamoto, A | 1 |
| Ernst, D; Hornemann, T; Kivrak-Pfiffner, F; Penno, A; Rohrer, L; Rütti, MF; von Eckardstein, A | 1 |
| Akiyama, M; Bahtiar, A; Ishida-Kitagawa, N; Matsumoto, T; Nakamura, T; Ogawa, T; Takeya, T; Yogo, K | 1 |
| Dunn, TM; Gable, K; Gupta, SD; Han, G; Harmon, JM; Niranjanakumari, S | 1 |
| Bertea, M; Hersberger, M; Hornemann, T; Marti-Jaun, J; Othman, A; Rütti, MF; von Eckardstein, A | 1 |
| Chathoth, S; Galadari, S; Hago, A; Kizhakkayil, J; Patel, M; Shahin, A; Thayyullathil, F | 1 |
| Li, R; Reiser, G | 1 |
| Kim, SY; Lee, CH; Lee, HJ; Noh, M; Park, MK; Shin, J | 1 |
| Scherer, SS | 1 |
| Brown, RH; Eichler, FS; Frosch, MP; Garofalo, K; Hornemann, T; Lee, HJ; Penno, A; Schmidt, BP; von Eckardstein, A | 1 |
| Andrea, H; Boles, E; Köhler, T; Schorsch, C | 1 |
| Armacki, M; Busch, T; Eiseler, T; Jansen, J; Joodi, G; Omary, MB; Seufferlein, T; Spatz, J; Temme, C; von Wichert, G | 1 |
| Bell, RD; Chow, N; Davis, TP; Goldman, SA; Griffin, JH; Guo, H; Wang, M; Wang, S; Yang, Q; Zhao, Z; Zlokovic, BV | 1 |
| Barattucci, A; Bonaccorsi, P; Di Gioia, ML; Leggio, A; Minuti, L; Romio, E; Siciliano, C; Temperini, A | 1 |
| Alecu, I; Bianchi, R; Cavaletti, G; Chiorazzi, A; Hornemann, T; Lauria, G; Lombardi, R; Meregalli, C; Oggioni, N; Othman, A; Porretta-Serapiglia, C; von Eckardstein, A; Wei, Y | 1 |
| Akagi, T; Esaki, K; Furuya, S; Hirabayashi, Y; Ogawa, T; Okamoto, M; Sayano, T; Sonoda, C; Suzuki, T; Yoshikawa, T | 1 |
| Jang, Y; Jiang, Q; Rao, X | 1 |
| Caiazzo, E; Cicala, C; d'Emmanuele di Villa Bianca, R; Gurgone, D; Mitidieri, E; Sorrentino, R; Tramontano, T | 1 |
| Allikmets, R; Badur, MG; Bahlo, M; Baldini, M; Bernstein, PS; Bonelli, R; Cai, C; Dorrell, MI; Eade, K; Egan, C; Eichler, F; Fallon, R; Friedlander, M; Fruttiger, M; Gantner, ML; Giles, S; Gillies, M; Guymer, R; Handzlik, MK; Harkins-Perry, S; Hart, BJ; Heeren, TFC; Ideguchi, Y; Kitano, M; Metallo, CM; Nagasaki, T; Okada, M; Sauer, L; Scheppke, L; Trombley, J; Wallace, M; Woods, SM | 1 |
| Chai, JF; Chew, WS; Ching, J; Herr, DR; Khoo, CM; Khor, IW; Kovalik, JP; Raichur, S; Sim, X; Tai, ES; Torta, F; Wenk, MR | 1 |
| Becker, KA; Bieberich, E; Bielawski, J; Doolen, S; Goins, L; Gulbins, E; McQuerry, KJ; Spassieva, SD; Sure, U; Taylor, BK; Uerschels, AK | 1 |
| Bae, JS; Choi, MK; Han, SH; Jin, HK; Kim, HJ; Kim, SH; Lee, JY; Park, CM; Park, MH; Schuchman, EH; Song, IS; Yu, E | 1 |
| Abegg, D; Adibekian, A; Gentina, S; Gomez, L; Guex, N; Hannich, JT; Haribowo, AG; Martinou, JC; Ovize, M; Paillard, M; Pillot, B; Riezman, H; Thibault, H; Zumbuehl, A | 1 |
| Armando, AM; Carlisle, AE; Doshi, MB; Gao, J; Greer, PL; Hwang, S; Kim, D; Lee, N; Li, R; Park, SJ; Quehenberger, O; Simin, K; Spears, ME; Torres, EM; Zhu, LJ | 1 |
| Aldrovandi, GM; Clark, JL; D'Aquila, R; Elliott, J; Fulcher, JA; Gorbach, PM; Kipke, MD; Li, F; Mustanski, B; Shoptaw, S; Tobin, NH; Zabih, S | 1 |
| Du, J; Huang, J; Lai, Y; Tian, Y; You, X | 1 |
5 review(s) available for serine and sphingosine
| Article | Year |
|---|---|
Sphingolipid biosynthesis and vitamin K metabolism in Bacteroides melaninogenicus.
Topics: Animals; Bacteroides; Electron Transport; Mutation; Oxo-Acid-Lyases; Palmitoyl Coenzyme A; Prevotella melaninogenica; Serine; Spheroplasts; Sphingolipids; Sphingomyelins; Sphingosine; Vitamin K | 1979 |
[Quantitative determination of phospholipids in human blood and organs].
Topics: Amino Alcohols; Choline; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Fatty Acids; Glycerol; Humans; Indicators and Reagents; Inositol; Methods; Phospholipids; Serine; Sphingosine | 1972 |
Biosynthesis of the sphingoid bases: a provocation.
Topics: Animals; Ceramides; Humans; Ketones; Models, Chemical; Oxidation-Reduction; Serine; Sphingolipids; Sphingosine | 1984 |
Lysosomal involvement in apoptosis.
Topics: Acridine Orange; Amides; Animals; Apoptosis; Caspases; Cathepsins; Detergents; Fluorescent Dyes; Iron; Lysosomes; Oxidation-Reduction; Oxidative Stress; Serine; Signal Transduction; Sphingosine; Vacuoles | 2001 |
Effects of sphingolipid metabolism disorders on endothelial cells.
Topics: Ceramides; Endothelial Cells; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Serine; Sphingolipids; Sphingosine | 2022 |
1 trial(s) available for serine and sphingosine
| Article | Year |
|---|---|
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Female; Hereditary Sensory and Autonomic Neuropathies; Humans; Infertility, Male; Lipids; Male; Mice; Mice, Transgenic; Middle Aged; Mutation, Missense; Neurotoxins; Pain Perception; Pilot Projects; Point Mutation; Psychomotor Performance; Sciatic Nerve; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Stereoisomerism; Young Adult | 2011 |
86 other study(ies) available for serine and sphingosine
| Article | Year |
|---|---|
Dihydrosphingosine growth inhibition and repression of 3-ketodihydrosphingosine synthetase activity in Bacteroides melaninogenicus.
Topics: Bacteroides; Dose-Response Relationship, Drug; Enzyme Repression; Kinetics; Oxo-Acid-Lyases; Palmitoyl Coenzyme A; Serine; Sphingosine | 1978 |
Studies on the mechanism of 3-ketosphinganine synthetase.
Topics: Animals; Ascomycota; Carbon-Carbon Ligases; Ligases; Microsomes, Liver; Palmitic Acids; Pichia; Rats; Serine; Species Specificity; Sphingosine | 1976 |
In vitro toxicology of fumonisins and the mechanistic implications.
Topics: Animals; Cell Death; Cell Division; Cells, Cultured; Ceramides; DNA; Epithelial Cells; Epithelium; Fumonisins; Kidney; Liver; Mycotoxins; Protein Biosynthesis; Rats; Serine; Sphingolipids; Sphingosine; Swine | 1992 |
Oleoylamine and sphingosine stimulation of phosphatidylserine synthesis by LA-N-2 cells is protein kinase C independent.
Topics: Amines; Choline; Diglycerides; Down-Regulation; Ethanolamines; Humans; Neuroblastoma; Oleic Acids; Phosphatidylserines; Protein Kinase C; Serine; Sphingosine; Tumor Cells, Cultured | 1992 |
Sphingosine and unsaturated fatty acids modulate the base exchange enzyme activities of rat brain membranes.
Topics: Animals; Brain; Cell Membrane; Choline; Diglycerides; Ethanolamine; Ethanolamines; Fatty Acids, Unsaturated; Models, Biological; Nucleotides; Phospholipids; Rats; Serine; Sphingosine | 1991 |
Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases.
Topics: Animals; Antigens, CD; Carbohydrate Sequence; Cell Survival; Cells, Cultured; Cerebellum; Galactose; Gangliosides; Glycosphingolipids; Lactosylceramides; Mice; Molecular Sequence Data; Neurons; Serine; Sphingolipids; Sphingosine | 1990 |
Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins.
Topics: Acyltransferases; Animals; Cells, Cultured; Fatty Acids; Lipoproteins; Liver; Male; Palmitic Acid; Palmitic Acids; Rats; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 1989 |
Sphingomyelin synthesis in Hymenolepis diminuta (Cestoda).
Topics: Acyltransferases; Alcohol Oxidoreductases; Animals; Ceramides; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Hymenolepis; Oxidoreductases; Palmitic Acid; Palmitic Acids; Palmitoyl Coenzyme A; Serine; Serine C-Palmitoyltransferase; Sphingomyelins; Sphingosine; Sphingosine N-Acyltransferase | 1985 |
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).
Topics: Acylation; Animals; Carbon Radioisotopes; Cells, Cultured; Mice; Serine; Sphingolipids; Sphingosine | 1986 |
Rapid turnover of sphingosine synthesized de novo from [14C]serine by Chinese hamster ovary cells.
Topics: Cell Line; Ceramides; Chromatography, Thin Layer; Serine; Sphingolipids; Sphingomyelins; Sphingosine | 1988 |
Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine.
Topics: Acyltransferases; Alanine; Animals; beta-Alanine; Biological Transport, Active; Cells, Cultured; Cricetinae; Female; In Vitro Techniques; Lipids; Microsomes, Liver; Rats; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 1988 |
Biosynthesis of unsaturated sphingolipid bases by microsomal preparations from oysters.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chromatography, Gas; Coenzyme A; Digestive System; Fatty Acids, Unsaturated; Glycols; Ketones; Mass Spectrometry; Microsomes; NADP; Ostreidae; Palmitic Acids; Serine; Spectrophotometry, Infrared; Sphingolipids; Sphingosine; Stereoisomerism | 1973 |
Observations on the biosynthesis of rat brain sphingolipids in vivo: formation of fatty acid amides.
Topics: Amides; Animals; Brain; Carbon Radioisotopes; Ceramides; Cerebrosides; Fatty Acids; Galactose; Glycosides; Rats; Serine; Sphingolipids; Sphingosine; Time Factors | 1974 |
Composition of myelin lipids and synthesis of 3-ketodihydrosphingosine in the vitamin B 6 -deficient developing rat.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Carbon Isotopes; Cerebrosides; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids; Female; Organ Size; Phospholipids; Pregnancy; Pyridoxine; Rats; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Vitamin B Deficiency | 1973 |
Identification of the enzymatic lesions responsible for the accumulation of acetylated sphingosine bases in the yeast Hansenula ciferri.
Topics: Acetyl Coenzyme A; Acetylation; Acetyltransferases; Ascomycota; Carbon Isotopes; Coenzyme A; Coenzyme A Ligases; Fatty Alcohols; Ketone Oxidoreductases; Ketones; Microsomes; Oxo-Acid-Lyases; Palmitic Acids; Serine; Species Specificity; Sphingosine; Tritium | 1973 |
The 3-ketodihydrosphingosine synthetase of Bacteroides melaninogenicus: induction by vitamin K.
Topics: Bacteroides; Carbon Isotopes; Cell-Free System; Chromatography, Thin Layer; Coenzyme A; Enzyme Induction; Kinetics; Oxo-Acid-Lyases; Palmitic Acids; Puromycin; Rifampin; Serine; Sphingosine; Time Factors; Vibration; Vitamin K | 1973 |
Sphingolipid biosynthesis by particulate fractions of normal and "quaking" mouse brain.
Topics: Animals; Brain; Carbon Isotopes; Ceramides; Choline; Chromatography, Thin Layer; Coenzyme A; Cytosine Nucleotides; Mice; Mice, Inbred Strains; Palmitic Acids; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Stearic Acids; Subcellular Fractions | 1971 |
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes.
Topics: Acyl Coenzyme A; Acyltransferases; Animals; Female; Microsomes, Liver; Pyridoxal Phosphate; Rats; Rats, Inbred BUF; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Subcellular Fractions; Substrate Specificity | 1984 |
Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture.
Topics: Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Culture Media; Mice; Palmitic Acid; Palmitic Acids; Phosphatidylethanolamines; Serine; Sphingolipids; Sphingosine | 1995 |
25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.
Topics: Animals; Ceramides; CHO Cells; Cholesterol Esters; Choline; Cricetinae; Culture Media; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Palmitic Acid; Palmitic Acids; Receptors, LDL; RNA, Messenger; Serine; Sphingomyelins; Sphingosine; Transferases (Other Substituted Phosphate Groups); Tritium | 1995 |
Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells.
Topics: Animals; Cell Membrane; Ceramides; CHO Cells; Choline; Cricetinae; Glucosylceramides; Kinetics; Serine; Sphingomyelins; Sphingosine; Tritium | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Modulation of the serine base exchange enzyme activity of rat brain membranes by amphiphilic cations and amphiphilic anions.
Topics: Amines; Animals; Anions; Brain; Cations; Cell Membrane; Choline; Ethanolamine; Ethanolamines; Hydrogen-Ion Concentration; Kinetics; Nitrogenous Group Transferases; Phosphatidylethanolamines; Rats; Serine; Sphingosine; Transferases | 1993 |
Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts.
Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Cell Division; CHO Cells; Choline; Cricetinae; Kinetics; L Cells; Mice; Palmitic Acid; Palmitic Acids; Phospholipids; Radioisotope Dilution Technique; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Tritium | 1993 |
Induction of ganglioside biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Ceramides; Embryo, Mammalian; Enzyme Inhibitors; Female; Galactose; Gangliosides; Glycosphingolipids; Humans; Kinetics; Morpholines; Neurites; Neurons; Pregnancy; Radioisotope Dilution Technique; Rats; Rats, Wistar; Serine; Sphingomyelins; Sphingosine; Stereoisomerism; Tritium | 1996 |
Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells.
Topics: Animals; Carboxy-Lyases; CHO Cells; Cricetinae; Ethanolamine; Ethanolamines; Fumonisins; Mycotoxins; Nitrogenous Group Transferases; Phosphatidylethanolamines; Phosphatidylserines; Serine; Sphingomyelins; Sphingosine; Transferases | 1996 |
Pathways of glycosphingolipid biosynthesis in SW13 cells in the presence and absence of vimentin intermediate filaments.
Topics: Acylation; Adrenal Cortex Neoplasms; Animals; Carcinoma, Small Cell; Ceramides; Endosomes; G(M1) Ganglioside; Galactose; Glucosamine; Glycosphingolipids; Golgi Apparatus; Humans; Mice; Serine; Sphingosine; Tumor Cells, Cultured; Vimentin | 1996 |
cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons.
Topics: Acyltransferases; Animals; Cells, Cultured; Mice; Neurons; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 1997 |
Activity of 3-ketosphinganine synthase during differentiation and aging of neuronal cells in culture.
Topics: Acyl Coenzyme A; Animals; Carbon-Carbon Ligases; Cells, Cultured; Cerebellum; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Ligases; Magnetic Resonance Spectroscopy; Neurons; Osmolar Concentration; Palmitoyl Coenzyme A; Proteins; Rats; Rats, Sprague-Dawley; Serine; Sphingosine; Time Factors | 1997 |
1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis.
Topics: Animals; Cells, Cultured; Ceramides; Hippocampus; Hydrolysis; Mice; Neurons; Serine; Sphingolipids; Sphingosine | 1998 |
Synthesis of sphingosine analogues: stereoselective synthesis of 3-deoxysphingosine and cis-isomers.
Topics: DNA Primase; Serine; Sphingosine; Stereoisomerism; Structure-Activity Relationship | 1997 |
Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena.
Topics: Animals; Apoptosis; Chromatin; DNA Fragmentation; Kinetics; Palmitic Acid; Phosphatidylinositols; Phosphorus Radioisotopes; Serine; Sphingosine; Tetrahymena; Tritium | 1999 |
Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging.
Topics: Cell Compartmentation; Cloning, Molecular; Genes, Fungal; Heat-Shock Response; Mutagenesis; Oligopeptides; Palmitic Acid; Peptides; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sphingolipids; Sphingosine; Tritium | 2000 |
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Animals; COS Cells; Enzyme Activation; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine | 2000 |
D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis.
Topics: Acyltransferases; Animals; Binding, Competitive; CHO Cells; Cricetinae; Palmitoyl Coenzyme A; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Tritium | 2000 |
Stereospecific total syntheses of sphingosine and its analogues from L-serine.
Topics: Serine; Sphingosine; Stereoisomerism | 2000 |
Differential labelling of sphingolipids by [3H]serine and ([3H]methyl)-methionine in fish leukocytes.
Topics: Animals; Bass; Isotope Labeling; Leukocytes; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Tritium; Vitamin U | 2000 |
Cell type specific localization of sphingomyelin biosynthesis.
Topics: Animals; Brefeldin A; Cell Membrane; Cells, Cultured; Ceramides; Fibroblasts; Gangliosides; Golgi Apparatus; Humans; Mice; Mice, Inbred Strains; Neuroblastoma; Neurons; Organ Specificity; Serine; Sphingomyelins; Sphingosine | 2000 |
Oxidation of aglycone of glycosphingolipids: serine and ceramide acid precursors for soluble glycoconjugates.
Topics: Animals; Ceramides; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Glycoconjugates; Glycolipids; Glycoproteins; Glycosphingolipids; Humans; Oxidation-Reduction; Serine; Solubility; Sphingosine | 2000 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Basic fibroblast growth factor-induced proliferation of primary astrocytes. evidence for the involvement of sphingomyelin biosynthesis.
Topics: Animals; Animals, Newborn; Astrocytes; Brefeldin A; Cell Division; Cells, Cultured; Ceramides; Cerebellum; Enzyme Activation; Fibroblast Growth Factor 2; Protein Processing, Post-Translational; Rats; Serine; Sphingomyelins; Sphingosine; Transferases (Other Substituted Phosphate Groups); Tritium | 2001 |
Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways.
Topics: Animals; Blotting, Western; Bradykinin; Cattle; Cell Line; COS Cells; DNA, Complementary; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Lymphokines; Lysophospholipids; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Sphingosine; Time Factors; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis.
Topics: Acyltransferases; Amino Acid Sequence; Arabidopsis; DNA, Complementary; DNA, Plant; Endoplasmic Reticulum; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Mutagenesis; Nicotiana; Open Reading Frames; Palmitoyl Coenzyme A; Protein Conformation; Saccharomyces cerevisiae; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 2001 |
Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase.
Topics: Blotting, Western; Breast; Calcium; Cell Line; Cell Membrane; Cells, Cultured; Ceramides; Chromatography, Affinity; Chromatography, Liquid; Chromatography, Thin Layer; Culture Media, Serum-Free; Enzyme Activation; Epithelial Cells; Ethanolamines; Humans; Lipoproteins; Lipoproteins, LDL; Lipoproteins, VLDL; Lysophospholipids; Microscopy, Fluorescence; Phospholipids; Protein Binding; Serine; Serine Endopeptidases; Sphingosine; Suramin; Time Factors; Trypsin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2002 |
Synthesis of D-erythro-dihydrosphingosine and D-xylo-phytosphingosine from a serine-derived 1,5-dioxaspiro[3.2]hexane template.
Topics: Animals; Heterocyclic Compounds; Immunosuppressive Agents; Indicators and Reagents; Porifera; Serine; Sphingosine; Spiro Compounds; Stereoisomerism; Templates, Genetic | 2002 |
Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.
Topics: Acetophenones; Benzopyrans; Cell Line; Cell Membrane; Cytosol; Enzyme Inhibitors; Epithelial Cells; Genistein; Glycerophospholipids; Humans; Isoenzymes; Lysophospholipids; Nasal Cavity; Oligonucleotides, Antisense; Phosphatidic Acids; Phospholipase D; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Proto-Oncogene Proteins pp60(c-src); Respiratory Mucosa; Serine; Sphingosine; Subcellular Fractions; Threonine; Time Factors | 2002 |
Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Brefeldin A; Cell Division; Cell Line; Ceramides; Choline; Cytosol; Endoplasmic Reticulum; Glioma; Golgi Apparatus; Insecta; Microscopy, Fluorescence; Nitric Oxide; Rats; Serine; Signal Transduction; Sphingomyelins; Sphingosine; Time Factors; Tumor Cells, Cultured | 2003 |
Synthesis and growth inhibitory activity of chiral 5-hydroxy-2-N-acyl-(3E)-sphingenines: ceramides with an unusual sphingoid backbone.
Topics: Antineoplastic Agents; Brain Chemistry; Breast Neoplasms; Catalysis; Ceramides; Chemistry, Organic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Serine; Sphingosine; Stereoisomerism; Tumor Cells, Cultured | 2003 |
Total syntheses of symbioramide derivatives from l-serine and their antileukemic activities.
Topics: Animals; Antineoplastic Agents; Catalysis; Combinatorial Chemistry Techniques; HL-60 Cells; Humans; Indicators and Reagents; Leukemia; Mice; Molecular Structure; Serine; Sphingosine; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Topics: Animals; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Muscle, Skeletal; Palmitic Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptor, Insulin; Serine; Sphingosine; Tyrosine | 2003 |
The biosynthesis of sphingosine. I. A study of the reaction with tritium-labeled serine.
Topics: Humans; Lipids; Serine; Sphingosine; Tritium | 1963 |
[On sphingosine].
Topics: Amino Alcohols; Butyrates; Serine; Sphingosine | 1955 |
SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I.
Topics: Acyl Coenzyme A; Acyltransferases; Belgium; Chromosome Mapping; Chromosomes, Human, Pair 9; Disease Progression; DNA Mutational Analysis; Exons; Female; Genes, Dominant; Hereditary Sensory and Autonomic Neuropathies; Humans; Middle Aged; Mutation; Pedigree; Protein Subunits; Serine; Serine C-Palmitoyltransferase; Sphingosine | 2004 |
Straightforward synthesis of sphinganines via a serine-derived Weinreb amide.
Topics: Amides; Ketones; Organometallic Compounds; Serine; Sphingosine; Stereoisomerism | 2004 |
Total synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B).
Topics: Animals; Antineoplastic Agents; Molecular Structure; Porifera; Serine; Sphingosine; Stereoisomerism | 2005 |
Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism.
Topics: 14-3-3 Proteins; Animals; Catalytic Domain; Cattle; Cell Membrane; Chromatography, Ion Exchange; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Ethanolamines; Fibroblasts; Gene Expression Regulation, Enzymologic; Immunoblotting; Kinetics; Lipid Metabolism; Lysophospholipids; Mice; Mice, Inbred BALB C; Myocardium; NIH 3T3 Cells; Phosphatidylserines; Phospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Structure, Tertiary; Serine; Signal Transduction; Sphingosine; Substrate Specificity | 2005 |
The mechanism of membrane targeting of human sphingosine kinase 1.
Topics: Amino Acid Sequence; Asparagine; Cell Line; Cell Membrane; DNA Mutational Analysis; Green Fluorescent Proteins; Humans; Kinetics; Lipids; Lysophospholipids; Mass Spectrometry; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Mutation; Peptides; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Phospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pressure; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Sphingosine; Surface Plasmon Resonance; Threonine; Time Factors; Transfection | 2005 |
Efflux of sphingolipids metabolically labeled with [1-3H]sphingosine, L-[3- 3H]serine and [9,10- 3H]palmitic acid from normal cells in culture.
Topics: Animals; Carbohydrate Sequence; Cells, Cultured; Cerebellum; Culture Media; Fibroblasts; G(M3) Ganglioside; Humans; Molecular Sequence Data; Palmitic Acid; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Reference Values; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Tritium | 2006 |
Versatile synthetic method for sphingolipids and functionalized sphingosine derivatives via olefin cross metathesis.
Topics: Alkenes; Amino Alcohols; Indicators and Reagents; Serine; Sphingolipids; Sphingosine | 2006 |
Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.
Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Gene Deletion; Gene Expression Regulation; Gene Expression Regulation, Fungal; Hot Temperature; Hydrogen-Ion Concentration; Membrane Proteins; Models, Biological; Mutagenesis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sphingolipids; Sphingosine; Substrate Specificity; Time Factors | 2007 |
A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine.
Topics: Amides; Chemistry, Pharmaceutical; Ketones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Protein Kinase C; Protein Kinase Inhibitors; Serine; Spectroscopy, Fourier Transform Infrared; Sphingosine; Stereoisomerism; Technology, Pharmaceutical | 2007 |
A concise and scalable synthesis of high enantiopurity (-)-D-erythro-sphingosine using peptidyl thiol ester-boronic acid cross-coupling.
Topics: Boronic Acids; Catalysis; Copper; Esters; Molecular Structure; Palladium; Serine; Sphingosine; Stereoisomerism; Sulfhydryl Compounds | 2007 |
Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum.
Topics: Catalysis; Crystallography, X-Ray; Models, Molecular; Palmitoyl Coenzyme A; Protein Conformation; Protein Structure, Tertiary; Serine; Serine C-Palmitoyltransferase; Sphingobacterium; Sphingosine | 2009 |
The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.
Topics: Catalysis; Cell Line; Chromatography, High Pressure Liquid; Gene Expression; Humans; Kinetics; Mass Spectrometry; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 2009 |
Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo.
Topics: Animals; Antigens, CD; Bone and Bones; Bone Density; Bone Marrow Cells; Esters; Female; Gene Expression Regulation; Giant Cells; In Vitro Techniques; Lactosylceramides; Membrane Microdomains; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; RANK Ligand; Serine; Serine C-Palmitoyltransferase; Sphingosine | 2009 |
A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity.
Topics: Alanine; Animals; Biocatalysis; Catalytic Domain; CHO Cells; Cricetinae; Cricetulus; Extracellular Space; Hereditary Sensory and Autonomic Neuropathies; Humans; Isoenzymes; Kinetics; Mice; Mutation; Protein Multimerization; Protein Structure, Quaternary; Serine; Serine C-Palmitoyltransferase; Sphingosine; Substrate Specificity | 2010 |
Deoxysphingoid bases as plasma markers in diabetes mellitus.
Topics: Aged; Alanine; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Progression; Female; Humans; Lipoproteins; Male; Middle Aged; Serine; Sphingolipids; Sphingosine; Statistics as Topic | 2010 |
Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoprecipitation; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Pyrans; Serine; Signal Transduction; Sphingosine; Spiro Compounds | 2011 |
Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sphingosine; Staurosporine | 2011 |
Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Movement; Cystamine; Cytoskeleton; Gene Expression Regulation, Neoplastic; Gene Silencing; GTP-Binding Proteins; Humans; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Keratin-8; MAP Kinase Signaling System; Pancreatic Neoplasms; Phosphorylation; Phosphorylcholine; Protein Glutamine gamma Glutamyltransferase 2; Protein Kinase Inhibitors; RNA, Small Interfering; Serine; Sphingosine; Transglutaminases | 2011 |
The debut of a rational treatment for an inherited neuropathy?
Topics: Animals; Female; Hereditary Sensory and Autonomic Neuropathies; Humans; Lipids; Male; Neurotoxins; Serine; Sphingosine | 2011 |
High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii.
Topics: Gene Deletion; Glycine Hydroxymethyltransferase; Humans; Metabolic Engineering; Pichia; Serine; Sphingolipids; Sphingosine | 2012 |
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.
Topics: Cell Line, Tumor; Cell Movement; Cytoskeleton; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Intermediate Filaments; Keratin-8; MAP Kinase Kinase Kinases; Pancreatic Neoplasms; Phosphorylation; Phosphorylcholine; Protein Kinase Inhibitors; Serine; Signal Transduction; Sphingosine; Stomach Neoplasms | 2012 |
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Blood Coagulation Factors; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cell Differentiation; Cell Movement; Cells, Cultured; Cerebral Ventricles; Dactinomycin; Enzyme-Linked Immunosorbent Assay; Female; Fetus; Flow Cytometry; Humans; Intermediate Filament Proteins; Ki-67 Antigen; Lysophospholipids; Male; Mutation; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurogenesis; Oligopeptides; Oncogene Protein v-akt; Receptors, Cell Surface; Receptors, Lysosphingolipid; Receptors, Proteinase-Activated; RNA Interference; RNA, Small Interfering; Serine; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors | 2013 |
Synthesis of D-erythro-sphinganine through serine-derived α-amino epoxides.
Topics: Epoxy Compounds; Serine; Sphingosine; Stereoisomerism | 2014 |
Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats.
Topics: Animals; Body Weight; Diabetic Neuropathies; Eating; Electrophysiology; Hereditary Sensory and Autonomic Neuropathies; Male; Rats; Rats, Sprague-Dawley; Serine; Sphingosine | 2015 |
L-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Animals; Brain; Cells, Cultured; Female; Gene Knockout Techniques; Lipid Droplets; Lipids; Mice; Phosphoglycerate Dehydrogenase; Serine; Sphingolipids; Sphingosine | 2015 |
Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment.
Topics: Antineoplastic Agents; Carbon Isotopes; Cell Death; Cell Line, Tumor; Ceramides; Chromans; Chromatography, Liquid; Fatty Acid Desaturases; HCT116 Cells; Humans; MCF-7 Cells; Nitrogen Isotopes; Oxidative Stress; Oxidoreductases; Serine; Sphingolipids; Sphingosine; Tandem Mass Spectrometry; Vitamin E | 2017 |
L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway.
Topics: Animals; Aorta; Cystathionine; Cystathionine beta-Synthase; Cysteine; Humans; Lysophospholipids; Mice; Serine; Sphingosine | 2020 |
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.
Topics: Adult; Aged; Animals; Disease Models, Animal; DNA Mutational Analysis; Exome; Female; Hereditary Sensory and Autonomic Neuropathies; Humans; Lipid Metabolism; Macula Lutea; Male; Mice; Middle Aged; Mutation; Pedigree; Retinal Telangiectasis; Risk Factors; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Young Adult | 2019 |
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.
Topics: Alzheimer Disease; Asian People; ATP-Binding Cassette Transporters; Carnitine; China; DNA-Binding Proteins; Female; Galactosyltransferases; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Glutathione Transferase; Glycosphingolipids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Lysophospholipids; Male; Membrane Proteins; Middle Aged; Parkinson Disease; Phosphoric Monoester Hydrolases; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Tandem Mass Spectrometry; Transcription Factors | 2020 |
Role of 1-Deoxysphingolipids in docetaxel neurotoxicity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Ceramides; Docetaxel; Female; Ganglia, Spinal; Lipids; Lysophospholipids; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes; Sensory Receptor Cells; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 2020 |
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Topics: Acetyl Coenzyme A; Acetylation; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Brain; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Humans; Male; Memory; Mice; Mice, Transgenic; Microglia; Mutagenesis; Neurons; Phagocytosis; Phosphotransferases (Alcohol Group Acceptor); Presenilin-1; Primary Cell Culture; Recombinant Proteins; Serine; Sphingosine | 2020 |
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding.
Topics: Alanine; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cell Division; Chaperonins; Feeding Behavior; Hypoxia; Ion Channels; Mice; Mice, Inbred C57BL; Mutation; Myocardial Reperfusion Injury; Protein Folding; Saccharomyces cerevisiae; Serine; Sphingosine | 2019 |
De novo sphingolipid biosynthesis necessitates detoxification in cancer cells.
Topics: Lipogenesis; Neoplasms; Oxidoreductases; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine | 2022 |
Gut dysbiosis and inflammatory blood markers precede HIV with limited changes after early seroconversion.
Topics: B-Cell Activating Factor; Bile Acids and Salts; Biomarkers; Cross-Sectional Studies; Cysteine; Dysbiosis; HIV Infections; Humans; Interleukin-8; Lipids; Lithocholic Acid; Serine; Seroconversion; Sphingosine; Sulfates; Tumor Necrosis Factor-alpha | 2022 |