serine and sirolimus

serine has been researched along with sirolimus in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (13.83)	18.2507
2000's	50 (53.19)	29.6817
2010's	25 (26.60)	24.3611
2020's	6 (6.38)	2.80

Authors

Authors	Studies
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S	1
Cafferkey, R; Johnson, RK; Livi, GP; McLaughlin, MM; Rosenberg, M; Stan, R	1
Brown, EJ; Chen, J; Schreiber, SL; Zheng, XF	1
Ballou, LM; de Groot, RP; Sassone-Corsi, P	1
Adachi, M; Imai, K; Minami, Y; Miyazaki, T; Reed, JC; Sekiya, M; Takayama, S; Taniguchi, T; Torigoe, T	1
Fadden, P; Haystead, TA; Lawrence, JC	1
DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J	1
Brunn, GJ; Fadden, P; Haystead, TA; Lawrence, JC	1
Belkowski, SM; Prystowsky, MB; Rubin, CS	1
Avison, MB; Denton, RM; Diggle, TA; Heesom, KJ	1
Chen, J; Fang, Y; Nuzzi, P; Vilella-Bach, M	1
Frech, M; Hemmings, BA; Kelly, JJ; Le Good, JA; Parekh, DB; Parker, PJ; Whelan, RD; Ziegler, WH	1
Cichy, SC; Cohen, P; Guo, S; Rena, G; Unterman, TG	1
Hara, K; Parekh, D; Parker, PJ; Yonezawa, K; Ziegler, W	1
Avruch, J; Reeves, SA; Wakisaka, S; Yokogami, K	1
Beal, PA; Comb, MJ; Peterson, RT; Schreiber, SL	1
Fadden, P; Haystead, TA; Lawrence, JC; Mothe-Satney, I; Yang, D	1
Kar, S; Quirion, R; Zheng, WH	1
Choder, M; Weisman, R	1
Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J	1
Kramer, DL; Pederson, TM; Rondinone, CM	1
Chen, J; Freund, GG; Hartman, ME; Villela-Bach, M	1
Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Takano, A; Uno, T; Usui, I	1
Aebersold, R; Burley, SK; Gingras, AC; Gygi, SP; Miron, M; Niedzwiecka, A; Polakiewicz, RD; Raught, B; Sonenberg, N; Wyslouch-Cieszynska, A	1
Cox, TC; Hopwood, B; Short, KM; Yi, Z	1
Bodine, SC; Lawrence, JC; Reynolds, TH	1
Brennan, P; Cantrell, D; Dennis, PB; Pullen, N; Saitoh, M; Thomas, G	1
Bertrand, L; Hue, L; Krause, U	1
Abraham, RT; Choi, KM; Lawrence, JC; Lin, TA; McMahon, LP	1
Czubayko, F; Franke, TF; List, HJ; Martin, MB; Morgan, E; Reiter, R; Stoica, A; Stoica, GE; Wellstein, A	1
Broussard, SR; Burgess, W; Dantzer, R; Jesse, K; Kelley, KW; Tang, Q	1
Bruemmer, D; Fleck, E; Kiyono, T; Law, RE; Liu, J; Van Herle, AJ; Yin, F	1
Ito, T; Kubota, H; Obata, T; Ota, K; Sasaki, T	1
Kupferwasser, D; Lam, J; Lee-Fruman, KK; Phin, S	1
Barres, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF	1
Beugnet, A; Proud, CG; Wang, X	1
Ferguson, G; Lawrence, JC; Mothe-Satney, I	1
Giraud, J; Lee, YH; Leshan, R; White, MF	1
Carlson, CJ; Rondinone, CM; White, MF	1
Freund, GG; Godbout, JP; Hartman, ME; Mazzocco, VR; Minor, KD; O'Connor, JC	1
Asnaghi, L; Bevilacqua, A; Calastretti, A; Canti, G; Capaccioli, S; D'Agnano, I; Delia, D; Gatti, G; Nicolin, A	1
Gautier, N; Hinault, C; Lawrence, JC; Mothe-Satney, I; Van Obberghen, E	1
Brattain, MG; Cookson, MM; Hauser, J; Sawhney, RS; Sharma, B	1
Hay, N; Lal, L; Li, Y; Minucci, S; Parmar, S; Platanias, LC; Sassano, A; Smith, J; Tallman, MS; Uddin, S	1
Gagnon, A; Marette, A; Sorisky, A; Tremblay, F; Veilleux, A	1
Crisby, M; Högberg, J; Pääjärvi, G; Roudier, E; Stenius, U	1
Beugnet, A; Murakami, M; Proud, CG; Wang, X; Yamanaka, S	1
Dames, SA; Grzesiek, S; Hall, MN; Mulet, JM; Rathgeb-Szabo, K	1
Crépieux, P; Fontaine, I; Gauthier, C; Guillou, F; Kara, E; Lécureuil, C; Martinat, N; Reiter, E; Sow, A; Tesseraud, S	1
Abraham, RT; Chiang, GG	1
Blenis, J; Holz, MK	1
Beck, A; Fiedler, H; Häring, HU; Kellerer, M; Moeschel, K; Müssig, K; Staiger, H	1
Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P	1
Kandror, KV; Tzatsos, A	1
Clavé, C; Iraqui, I; Pinan-Lucarré, B	1
Henske, EP; Karbowniczek, M; Robertson, GP	1
Brûlé, S; Hee Um, S; Krebs, M; Li, Y; Marette, A; Masuda, K; Polakiewicz, RD; Roden, M; Sun, XJ; Thomas, G; Tremblay, F	1
Aebersold, R; Djouder, N; Gstaiger, M; Hess, D; Krek, W; Metzler, SC; Schmidt, A; Wirbelauer, C	1
Ceci, M; Condorelli, G; Ellingsen, O; Gallo, P; Grimaldi, S; Kemi, OJ; Smith, GL; Wisloff, U	1
Al-Younes, H; Braun, PR; Gussmann, J; Klein, J; Meyer, TF; Schneider, E	1
Bernath, A; Gera, J; Jo, OD; Lichtenstein, A; Martin, J; Masri, J	1
Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H	1
Albert, L; Gulati, N; Jhanwar-Uniyal, M; Karsy, M; Murali, R	1
Fan, GC; Jones, WK; Kranias, EG; Molkentin, JD; Qian, J; Ren, X; Wang, X; Zhang, P	1
An, D; Feener, EP; Goodyear, LJ; Hirshman, MF; Koh, HJ; Taylor, EB; Toyoda, T; Treebak, JT; Witczak, CA; Wojtaszewski, JF; Xie, J	1
Fujita, N; Harris, TE; Péterfy, M; Reue, K	1
Acosta-Jaquez, HA; Dunlop, EA; Ekim, B; Fingar, DC; Maj, NE; Soliman, GA; Tee, AR	1
Carvalheira, JB; Carvalho, HF; Clemente, CF; Dalla Costa, AP; Franchini, KG; Nadruz, W	1
Hoeffer, CA; Klann, E; McBride, SM; Miyawaki, T; Sharma, A; Takayasu, Y; Zukin, RS	1
Greene, LA; Jackson-Lewis, V; Jin, ZH; Malagelada, C; Przedborski, S	1
Diamant, M; Guigas, B; Jazet, IM; Kriek, J; Maassen, JA; Nascimento, EB; Ouwens, DM; Snel, M; van der Zon, GC	1
Dao-Feng, B; Wei, D; Xin-Long, C; Zhao-Fan, X	1
Bowers, DC; Brugarolas, J; Gargan, L; Kucejova, B; Margraf, L	1
Hers, I; Hunter, RW; Moore, SF	1
Chen, A; Chin, S; Cruz, J; Glass, DJ; Hu, SI; Ibebunjo, C; Katz, M; Qi, X; Zhao, S	1
Biagioni, F; Fabrizi, C; Fornai, F; Fumagalli, L; Lenzi, P; Pompili, E; Somma, F	1
Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL	1
Li, H; Liang, Z; Liu, Y; Qiao, X; Run, X; Su, Y; Sun, S; Wang, J; Wang, T	1
Guo, X; Hao, S; Li, J; Liu, Y; Wu, H; Zheng, Q	1
Proud, CG; Stead, RL	1
Krześniak, M; Matuszczyk, I; Rusin, M; Zajkowicz, A	1
Coughlan, KA; Ruderman, NB; Saha, AK; Valentine, RJ	1
Chen, S; Chen, Y; Dan, X; Deng, H; Feng, W; Gong, X; Li, L; Miao, D; Wu, T; Yu, L	1
Hatzoglou, M; Kazimierczak, U; Khoutorsky, A; Koromilas, AE; Krishnamoorthy, J; Kristof, AS; Mounir, Z; Staschke, KA; Tenkerian, C; Wang, S	1
Chai, J; Chen, D; Guo, H; Kou, B; Shi, Y; Yan, X; Zhu, Z	1
Albac, C; Allinquant, B; Dorard, E; Gorisse-Hussonnois, L; Guihenneuc-Jouyaux, C; Potier, MC	1
Chatterjee, B; Cropper, J; Jiang, S; Mirkheshti, N; Park, S; Song, CS; Werner, SL	1
Beggs, RE; Bose, S; Crapuchettes, ME; D'Abronzo, LS; deVere White, RW; Durbin-Johnson, BP; Ghosh, PM; Melgoza, FU; Mudryj, M; Siddiqui, S; Tepper, CG; Vinall, RL	1
Alharthi, ASM; Batistel, F; Helmbrecht, A; Loor, JJ; Parys, C; Shen, X; Trevisi, E; Xu, T	1
Altea-Manzano, P; Broekaert, D; Doglioni, G; Fendt, SM; Funk, CM; Geldhof, V; Grünewald, TGP; Hunter, KW; Lunt, SY; Planque, M; Pranzini, E; Rinaldi, G; Ross, C; Rossi, M; Teoh, ST; Van Elsen, J	1
Alain, T; Anton, L; Berman, AJ; Celucci, G; Chaker-Margot, M; Dajadian, C; Damgaard, CK; Fonseca, BD; Graber, TE; Hearnden, J; Hoang, HD; Hollensen, AK; Jia, JJ; Lahr, RM; Livingstone, M; Maier, T; Moraes, BJ; Niklaus, MR; Pena, IA; Pointet, R; Smith, EM; Solgaard, MT; Wang, XD; Yang, AD; Yu, Y	1
Dai, J; Hong, Y; Hu, Y; Jiang, P; Li, R; Liu, D; Lv, H; Song, M; Wang, H; Wang, Z; Yao, S; Zhang, X; Zhao, G; Zhou, Z	1
Chan, MH; Chang, WT; Chen, HH; Kuo, TH; Sung, CW	1
Baskaran, P; Bateman, JM; Granat, L; Mihaylov, SR; Murn, J; Shah, K; Tee, AR; Ultanir, SK; Vinsland, E	1

Other Studies

94 other study(ies) available for serine and sirolimus

Article	Year
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones	2022
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. The Journal of biological chemistry, 1994, Dec-23, Volume: 269, Issue:51 Topics: Amino Acid Sequence; Antifungal Agents; Carrier Proteins; Cell Cycle Proteins; Conserved Sequence; DNA-Binding Proteins; Fungal Proteins; Heat-Shock Proteins; Humans; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Sirolimus; Tacrolimus; Tacrolimus Binding Proteins	1994
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proceedings of the National Academy of Sciences of the United States of America, 1995, May-23, Volume: 92, Issue:11 Topics: Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Circular Dichroism; Cloning, Molecular; DNA-Binding Proteins; Heat-Shock Proteins; Humans; Immunosuppressive Agents; Kinetics; Mammals; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Peptide Fragments; Polyenes; Protein Biosynthesis; Protein Conformation; Rats; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Serine; Sirolimus; Tacrolimus; Tacrolimus Binding Proteins; Transcription, Genetic	1995
Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell, 1994, Oct-07, Volume: 79, Issue:1 Topics: Amino Acid Sequence; Animals; Blood Proteins; Cell Line; Cyclic AMP Response Element Modulator; DNA; DNA-Binding Proteins; DNA, Complementary; Enzyme Activation; Mitogens; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Polyenes; Protein Binding; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Repressor Proteins; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Transcriptional Activation; Transfection; Up-Regulation	1994
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. Blood, 1996, Dec-01, Volume: 88, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Carrier Proteins; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Hematopoietic Stem Cells; Humans; Interleukin-2; Isoflavones; Janus Kinase 3; Lymphocytes; Mice; Phosphorylation; Phytohemagglutinins; Polyenes; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-2; RNA, Messenger; Serine; Signal Transduction; Sirolimus; Stimulation, Chemical; Tacrolimus; Transcription Factors; Transfection	1996
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. The Journal of biological chemistry, 1997, Apr-11, Volume: 272, Issue:15 Topics: Adipocytes; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Eukaryotic Initiation Factor-4E; Immunosuppressive Agents; Insulin; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Polyenes; Rats; Repressor Proteins; Serine; Sirolimus; Structure-Activity Relationship	1997
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. The Journal of biological chemistry, 1997, Jun-13, Volume: 272, Issue:24 Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin	1997
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. The Journal of biological chemistry, 1997, Dec-19, Volume: 272, Issue:51 Topics: Amino Acid Sequence; Animals; Antibodies; Binding Sites; Carrier Proteins; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Polyenes; Proline; Rats; Serine; Sirolimus; Substrate Specificity; Threonine	1997
Isolation and analysis of a T cell clone variant exhibiting constitutively phosphorylated Ser133 cAMP response element-binding protein. Journal of immunology (Baltimore, Md. : 1950), 1998, Jul-15, Volume: 161, Issue:2 Topics: Cell Separation; Cellular Senescence; Clone Cells; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Induction; Humans; Interleukin-2; Phosphorylation; Polyenes; Proliferating Cell Nuclear Antigen; Serine; Sirolimus; T-Lymphocytes, Helper-Inducer	1998
Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111). The Biochemical journal, 1998, Nov-15, Volume: 336 ( Pt 1) Topics: Adipose Tissue; Amino Acid Sequence; Animals; Carrier Proteins; Chromatography, Ion Exchange; Chromatography, Thin Layer; Insulin; Intracellular Signaling Peptides and Proteins; Male; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein Kinases; Rats; Rats, Wistar; Serine; Sirolimus; Trypsin	1998
The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression. The Journal of biological chemistry, 1999, Feb-12, Volume: 274, Issue:7 Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Carrier Proteins; Catalysis; Cell Line; G1 Phase; Humans; Immunophilins; Immunosuppressive Agents; Microinjections; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; S Phase; Sequence Homology, Amino Acid; Serine; Sirolimus; Tacrolimus Binding Proteins; TOR Serine-Threonine Kinases; Tryptophan; Tumor Cells, Cultured	1999
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. Current biology : CB, 1999, May-20, Volume: 9, Issue:10 Topics: Animals; Binding Sites; Cell Line; Chromones; Enzyme Inhibitors; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Serine; Sirolimus; Substrate Specificity	1999
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. The Journal of biological chemistry, 1999, Jun-11, Volume: 274, Issue:24 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Androstadienes; Antibody Specificity; bcl-Associated Death Protein; Caenorhabditis elegans Proteins; Carrier Proteins; Consensus Sequence; DNA-Binding Proteins; Enzyme Activation; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Sirolimus; Threonine; Transcription Factors; Wortmannin	1999
Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon. The Journal of biological chemistry, 1999, Dec-03, Volume: 274, Issue:49 Topics: Allosteric Regulation; Amino Acids; Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoenzymes; Leucine; Morpholines; Naphthalenes; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Kinases; Serine; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases; Transfection	1999
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Current biology : CB, 2000, Jan-13, Volume: 10, Issue:1 Topics: Cell Line; Ciliary Neurotrophic Factor; DNA-Binding Proteins; Humans; MAP Kinase Signaling System; Peptide Fragments; Phosphorylation; Phosphoserine; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Trans-Activators	2000
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. The Journal of biological chemistry, 2000, Mar-10, Volume: 275, Issue:10 Topics: Amino Acid Sequence; Androstadienes; Animals; Humans; Immunization; Jurkat Cells; Molecular Sequence Data; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rabbits; Serine; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin	2000
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. Molecular and cellular biology, 2000, Volume: 20, Issue:10 Topics: Amino Acids; Carrier Proteins; Eukaryotic Initiation Factor-4E; Insulin; Mutation; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Repressor Proteins; RNA Caps; Serine; Sirolimus; Threonine	2000
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50 Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin	2000
The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine. The Journal of biological chemistry, 2001, Mar-09, Volume: 276, Issue:10 Topics: Amino Acid Sequence; Antifungal Agents; Arginine; Blotting, Western; Cell Cycle Proteins; Cloning, Molecular; Cold Temperature; Conserved Sequence; Drug Resistance; Epitopes; Flow Cytometry; Fungal Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Osmosis; Oxidative Stress; Peptidylprolyl Isomerase; Phenotype; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Kinases; Protein Structure, Tertiary; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Serine; Sirolimus; Tacrolimus Binding Protein 1A; Time Factors	2001
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage. The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13 Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection	2001
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation. Diabetes, 2001, Volume: 50, Issue:1 Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin	2001
Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation. Biochemical and biophysical research communications, 2001, Jan-26, Volume: 280, Issue:3 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Line; Humans; Immunophilins; Insulin Receptor Substrate Proteins; Interferon-alpha; Janus Kinase 1; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Rats; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine	2001
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Molecular and cellular biology, 2001, Volume: 21, Issue:15 Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cytosol; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Glucose; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tyrosine	2001
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes & development, 2001, Nov-01, Volume: 15, Issue:21 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA Mutational Analysis; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Isoelectric Focusing; Mass Spectrometry; Molecular Sequence Data; Mutation; Peptide Mapping; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Ribosomes; RNA, Messenger; Sequence Homology, Amino Acid; Serine; Sirolimus; Spectrometry, Fluorescence; Threonine; Transfection	2001
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. BMC cell biology, 2002, Volume: 3 Topics: Amino Acid Motifs; Binding Sites; Dimerization; Genetic Diseases, X-Linked; Humans; Ligases; Microtubule Proteins; Microtubule-Associated Proteins; Microtubules; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Subunits; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Serine; Signal Transduction; Sirolimus; Smith-Lemli-Opitz Syndrome; Threonine; Transcription Factors; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases	2002
Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. The Journal of biological chemistry, 2002, May-17, Volume: 277, Issue:20 Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Animals; Diaphragm; HIV Envelope Protein gp120; Insulin; Muscle, Skeletal; Phosphorylation; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Serine; Sirolimus; TOR Serine-Threonine Kinases; Weight-Bearing	2002
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. The Journal of biological chemistry, 2002, May-31, Volume: 277, Issue:22 Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Binding Sites; Cell Line; Enzyme Inhibitors; Genes, Dominant; Glutathione Transferase; Humans; Immunoblotting; Insulin; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transfection; Wortmannin	2002
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. European journal of biochemistry, 2002, Volume: 269, Issue:15 Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamine; Hepatocytes; Male; Marine Toxins; Multienzyme Complexes; Okadaic Acid; Oligomycins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Serine; Sirolimus	2002
The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin. Molecular and cellular biology, 2002, Volume: 22, Issue:21 Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Kinetics; Models, Biological; Mutagenesis, Site-Directed; Mutation; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Sirolimus; Substrate Specificity; Threonine; Time Factors; TOR Serine-Threonine Kinases; Transfection	2002
Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:5 Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Fulvestrant; Genistein; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Serine; Signal Transduction; Sirolimus; Tumor Cells, Cultured; Tyrphostins; Wortmannin	2003
Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms. Journal of neuroimmunology, 2003, Volume: 135, Issue:1-2 Topics: Androstadienes; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Survival; Cells, Cultured; Chromones; Hematopoietic Stem Cells; Insulin-Like Growth Factor I; Interleukin-3; Interleukin-4; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Sirolimus; Wortmannin	2003
Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells. Biochemical and biophysical research communications, 2003, Mar-28, Volume: 303, Issue:1 Topics: Animals; Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Cell Cycle Proteins; Cell Division; Cells, Cultured; DNA; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; Endothelium, Vascular; Muscle, Smooth; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Serine; Sirolimus; Transcription Factors; Transcriptional Activation; Transfection	2003
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. The Journal of biological chemistry, 2003, Jun-06, Volume: 278, Issue:23 Topics: Antifungal Agents; DNA-Binding Proteins; Eukaryotic Initiation Factor-2; Histidine; Phosphorylation; Protein Biosynthesis; Protein Kinases; RNA, Messenger; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Signal Transduction; Sirolimus	2003
Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1. The Biochemical journal, 2003, Jul-15, Volume: 373, Issue:Pt 2 Topics: 3-Phosphoinositide-Dependent Protein Kinases; Androstadienes; Antineoplastic Agents; Cells, Cultured; Humans; Immunosuppressive Agents; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Mutation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Proline; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Sirolimus; Threonine; Transfection; Wortmannin	2003
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes. The Journal of biological chemistry, 2003, Jul-18, Volume: 278, Issue:29 Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptor, Insulin; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine	2003
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. The Journal of biological chemistry, 2003, Oct-17, Volume: 278, Issue:42 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Binding Sites; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA, Complementary; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Mutation; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Rats; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection	2003
Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E. The Journal of biological chemistry, 2003, Nov-28, Volume: 278, Issue:48 Topics: Adaptor Proteins, Signal Transducing; Alanine; Binding Sites; Carrier Proteins; Cell Cycle Proteins; Cell Line; DNA, Complementary; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Genetic Vectors; Humans; Insulin; Mutation; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Structure, Tertiary; Serine; Sirolimus; Threonine; Transfection	2003
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. The Journal of biological chemistry, 2004, Jan-30, Volume: 279, Issue:5 Topics: Amino Acid Sequence; Amino Acids; Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Line; CHO Cells; Cricetinae; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphoproteins; Phosphorylation; Point Mutation; Precipitin Tests; Rats; Serine; Signal Transduction; Sirolimus; Time Factors; Wortmannin	2004
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochemical and biophysical research communications, 2004, Apr-02, Volume: 316, Issue:2 Topics: Adipocytes; Amino Acids; Animals; Anisomycin; Cell Line; Cytosol; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2004
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus. The Journal of biological chemistry, 2004, Jul-02, Volume: 279, Issue:27 Topics: Amino Acid Motifs; Animals; Blood Glucose; Blotting, Western; Cell Line; Diabetes Mellitus, Type 2; Glucose; Heterozygote; Humans; Insulin; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells	2004
Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene, 2004, Jul-29, Volume: 23, Issue:34 Topics: Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; G2 Phase; Microtubules; Mitosis; Mutation; Nocodazole; Paclitaxel; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2004
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41 Topics: Amino Acids; Animals; Binding Sites; Biological Transport; Blotting, Western; Carrier Proteins; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Hepatocytes; Immunoprecipitation; Insulin; Intracellular Signaling Peptides and Proteins; Male; Okadaic Acid; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Recombinant Proteins; Serine; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases	2004
Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells. The Journal of biological chemistry, 2004, Nov-05, Volume: 279, Issue:45 Topics: Autocrine Communication; Binding Sites; Biotinylation; Blotting, Western; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genes, Dominant; Humans; Immunoblotting; Indoles; Integrin alpha2; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Plasmids; Protein Kinase C; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Sirolimus; Threonine; Time Factors; Transfection; Transforming Growth Factor alpha	2004
Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood, 2005, Feb-15, Volume: 105, Issue:4 Topics: Cell Differentiation; Cell Line, Tumor; Enzyme Activation; Eukaryotic Initiation Factor-4E; Growth Inhibitors; Humans; Leukemia, Promyelocytic, Acute; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA Caps; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tretinoin	2005
Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology, 2005, Volume: 146, Issue:3 Topics: 3-O-Methylglucose; 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Cell Membrane; Deoxyglucose; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Humans; Immunoblotting; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Time Factors; TOR Serine-Threonine Kinases	2005
HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:3 Topics: Animals; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Enzyme Inhibitors; Female; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Insulin; Liver; Liver Neoplasms; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pravastatin; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2005
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Molecular and cellular biology, 2005, Volume: 25, Issue:7 Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amino Acids; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chromones; Cricetinae; Eukaryotic Initiation Factor-4E; Humans; Insulin; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Morpholines; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Rats; Ribosomal Protein S6 Kinases; Sequence Alignment; Serine; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases	2005
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability. The Journal of biological chemistry, 2005, May-27, Volume: 280, Issue:21 Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Cysteine; Disulfides; Drug Stability; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Mutagenesis; Oxidation-Reduction; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Structure, Secondary; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Serine; Sirolimus; Structure-Activity Relationship; Temperature	2005
Follicle-stimulating hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/Ser 424 in primary Sertoli cells. Molecular endocrinology (Baltimore, Md.), 2005, Volume: 19, Issue:7 Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Follicle Stimulating Hormone; Male; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Sertoli Cells; Sirolimus; Threonine; TOR Serine-Threonine Kinases	2005
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27 Topics: Anti-Bacterial Agents; Blood Proteins; Breast Neoplasms; Drug Resistance; HeLa Cells; Humans; In Vitro Techniques; Kidney; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Serine; Sirolimus; TOR Serine-Threonine Kinases	2005
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. The Journal of biological chemistry, 2005, Jul-15, Volume: 280, Issue:28 Topics: Alleles; Androstadienes; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Inhibitors; Genetic Vectors; Humans; Immunoblotting; Immunoprecipitation; Insulin; Models, Biological; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; RNA, Small Interfering; Serine; Signal Transduction; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases; Wortmannin	2005
Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1. The Journal of biological chemistry, 2005, Sep-23, Volume: 280, Issue:38 Topics: Androstadienes; Animals; Anthracenes; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Densitometry; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Gene Transfer Techniques; Glutathione Transferase; Immunoassay; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Peptides; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Rats; Retroviridae; Serine; Signal Transduction; Sirolimus; Transfection; Tumor Necrosis Factor-alpha; Wortmannin	2005
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. The Journal of biological chemistry, 2005, Oct-14, Volume: 280, Issue:41 Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Middle Aged; Okadaic Acid; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Time Factors; Tyrosine	2005
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Molecular and cellular biology, 2006, Volume: 26, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Receptor Substrate Proteins; Leucine; Mice; Monomeric GTP-Binding Proteins; Mutation; Neuropeptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; Ras Homolog Enriched in Brain Protein; Rats; Regulatory-Associated Protein of mTOR; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2006
Podospora anserina target of rapamycin. Current genetics, 2006, Volume: 50, Issue:1 Topics: Alanine; Alleles; Amino Acid Motifs; Amino Acid Sequence; Antifungal Agents; Base Sequence; Consensus Sequence; Fungal Proteins; Genes, Fungal; Growth; Hyphae; Molecular Sequence Data; Molecular Weight; Mutation, Missense; Open Reading Frames; Podospora; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Sirolimus; Vacuoles	2006
Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization. The Journal of biological chemistry, 2006, Sep-01, Volume: 281, Issue:35 Topics: Cell Line; Dimerization; Gene Expression Regulation; Humans; Monomeric GTP-Binding Proteins; Neuropeptides; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Ras Homolog Enriched in Brain Protein; Serine; Signal Transduction; Sirolimus	2006
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, 2007, Aug-28, Volume: 104, Issue:35 Topics: Animals; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Nutritional Status; Obesity; Phosphoproteins; Phosphorylation; RNA, Messenger; RNA, Small Interfering; Serine; Sirolimus	2007
S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Molecular cell, 2007, Oct-12, Volume: 28, Issue:1 Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-Associated Death Protein; Cell Line; Cell Survival; Feedback, Physiological; Humans; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mitochondria; Molecular Chaperones; Molecular Sequence Data; Multiprotein Complexes; Protein Phosphatase 1; Protein Structure, Tertiary; Recombinant Fusion Proteins; Repressor Proteins; Ribosomal Protein S6 Kinases; RNA, Small Interfering; Sequence Alignment; Serine; Signal Transduction; Sirolimus	2007
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. Journal of cellular physiology, 2008, Volume: 214, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta, Thoracic; Cardiomegaly; Carrier Proteins; Cell Cycle Proteins; Cell Size; Constriction, Pathologic; Echocardiography; Enzyme Activation; Eukaryotic Initiation Factors; Exercise Test; Female; Heart Ventricles; Hypertrophy; Mice; Mice, Inbred C57BL; Models, Biological; Myocardium; Myocytes, Cardiac; Phosphoproteins; Phosphorylation; Physical Conditioning, Animal; Protein Kinases; Proto-Oncogene Proteins c-akt; Random Allocation; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases	2008
Competitive inhibition of amino acid uptake suppresses chlamydial growth: involvement of the chlamydial amino acid transporter BrnQ. Journal of bacteriology, 2008, Volume: 190, Issue:5 Topics: Amino Acid Transport Systems; Amino Acids; Bacterial Proteins; Biological Transport; Cell Survival; Chlamydia; Chromatography, High Pressure Liquid; Cycloheximide; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Glycine; HeLa Cells; Humans; Isoleucine; Leucine; Methionine; Microscopy, Confocal; Microscopy, Electron, Transmission; Oligonucleotide Array Sequence Analysis; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Serine; Sirolimus; Threonine	2008
Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling. The Journal of biological chemistry, 2008, Aug-22, Volume: 283, Issue:34 Topics: Animals; Antibiotics, Antineoplastic; Binding Sites; Cell Line; Cell Line, Tumor; Cyclin D1; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Ribosomes; Serine; Sirolimus	2008
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424. Journal of cellular physiology, 2009, Volume: 219, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin	2009
Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility. International journal of oncology, 2009, Volume: 35, Issue:4 Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Enzyme Activation; Fibronectins; Glioblastoma; Humans; Morpholines; Multiprotein Complexes; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Regulatory-Associated Protein of mTOR; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Serine; Signal Transduction; Sirolimus; STAT3 Transcription Factor; Threonine; Time Factors; TOR Serine-Threonine Kinases	2009
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation research, 2009, Dec-04, Volume: 105, Issue:12 Topics: Alanine; Animals; Apoptosis; Autophagy; Base Sequence; Disease Models, Animal; Heart Failure; HSP20 Heat-Shock Proteins; Humans; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Myocardial Contraction; Myocardium; Necrosis; Phosphorylation; Recovery of Function; Reperfusion Injury; Serine; Sirolimus; Time Factors; Ventricular Function, Left; Ventricular Pressure	2009
Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:2 Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Androstadienes; Animals; Electric Stimulation; Electroporation; Female; Gene Transfer Techniques; Glucose; GTPase-Activating Proteins; Humans; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Muscle Contraction; Muscle, Skeletal; Mutation; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quadriceps Muscle; Recombinant Proteins; Ribonucleotides; Serine; Sirolimus; Tandem Mass Spectrometry; Time Factors; Wortmannin; Young Adult	2010
Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. The Journal of biological chemistry, 2010, Feb-05, Volume: 285, Issue:6 Topics: 14-3-3 Proteins; 3T3-L1 Cells; Active Transport, Cell Nucleus; Adipocytes; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Nucleus; Cytoplasm; Humans; Immunoprecipitation; Insulin; Mice; Microscopy, Confocal; Mutation; Nuclear Localization Signals; Nuclear Proteins; Phosphatidate Phosphatase; Phosphorylation; Protein Binding; Serine; Sirolimus	2010
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. The Journal of biological chemistry, 2010, Mar-12, Volume: 285, Issue:11 Topics: 3T3-L1 Cells; Animals; Antibiotics, Antineoplastic; Antibodies; Catalysis; Cell Line, Transformed; Fibroblasts; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Rabbits; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors	2010
FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex. Cardiovascular research, 2010, Jun-01, Volume: 86, Issue:3 Topics: Actins; Animals; Animals, Newborn; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Intracellular Signaling Peptides and Proteins; Leucine; Matrix Metalloproteinase 2; Mechanotransduction, Cellular; Myocardium; Oligopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; RNA Interference; Serine; Sirolimus; Stress, Mechanical; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Tyrosine	2010
Dysregulation of mTOR signaling in fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-13, Volume: 30, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; CA1 Region, Hippocampal; Carrier Proteins; Cell Cycle Proteins; Cognition Disorders; Disease Models, Animal; Eukaryotic Initiation Factor-4A; Eukaryotic Initiation Factors; Excitatory Postsynaptic Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression Regulation; Immunoprecipitation; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Receptors, Metabotropic Glutamate; Serine; Signal Transduction; Sirolimus	2010
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-20, Volume: 30, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Death; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Serine; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase	2010
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cellular signalling, 2010, Volume: 22, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Mice; Muscle, Skeletal; NIH 3T3 Cells; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Serine; Sirolimus; Threonine; Transcription Factors; Wortmannin	2010
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn. Burns : journal of the International Society for Burn Injuries, 2011, Volume: 37, Issue:1 Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Burns; C-Peptide; Disease Models, Animal; Glucose Clamp Technique; Immunohistochemistry; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Serine; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2011
mTORC1 activation in childhood ependymoma and response to sirolimus. Journal of neuro-oncology, 2011, Volume: 103, Issue:3 Topics: Brain Neoplasms; Child, Preschool; Ependymoma; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Ribosomal Protein S6; Serine; Sirolimus; TOR Serine-Threonine Kinases	2011
mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. The Journal of biological chemistry, 2011, Jul-15, Volume: 286, Issue:28 Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Blood Platelets; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Naphthyridines; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Sirolimus; Thrombin; Transcription Factors; Type C Phospholipases	2011
MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle. Science signaling, 2012, Feb-14, Volume: 5, Issue:211 Topics: Animals; Arginine; Blotting, Western; Cell Line; Dexamethasone; Eukaryotic Initiation Factor-4G; Insulin-Like Growth Factor I; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy; Myoblasts; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Serine; Signal Transduction; Sirolimus; Starvation; TOR Serine-Threonine Kinases	2012
Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures. Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:11 Topics: Adenine; Adjuvants, Immunologic; Aldehydes; Analysis of Variance; Animals; Asparagine; Autophagy; Brain; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; L-Lactate Dehydrogenase; Lithium Chloride; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphorylation; Serine; Sirolimus; Tetrazolium Salts; Thiazoles; Trimethyltin Compounds; Vacuoles	2012
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways. Behavioural brain research, 2012, Oct-01, Volume: 234, Issue:2 Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Freezing Reaction, Cataleptic; Guanosine; Hindlimb Suspension; Immunosuppressive Agents; Male; Mice; N-Methylaspartate; Nitric Oxide; Phosphatidylinositol 3-Kinases; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sirolimus; Swimming; TOR Serine-Threonine Kinases	2012
Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase. Neurochemistry international, 2013, Volume: 62, Issue:4 Topics: Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Humans; Phosphorylation; Serine; Sirolimus; tau Proteins	2013
Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. Acta biochimica et biophysica Sinica, 2013, Volume: 45, Issue:4 Topics: Antibiotics, Antineoplastic; Blotting, Western; Butadienes; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Isoquinolines; Nitriles; Oxygen; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Serine; Sirolimus; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A	2013
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a). FEBS letters, 2013, Aug-19, Volume: 587, Issue:16 Topics: Alanine; Amino Acid Sequence; Animals; Cell Line, Tumor; Enzyme Activation; Eukaryotic Initiation Factor-4E; Fibroblasts; Gene Expression Regulation, Enzymologic; Guanosine Triphosphate; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Serine; Sirolimus	2013
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. Mechanisms of ageing and development, 2014, Volume: 139 Topics: Aging; Antibiotics, Antineoplastic; Cell Line, Tumor; Dactinomycin; Humans; Lung Neoplasms; Nuclear Proteins; Phosphorylation; Promyelocytic Leukemia Protein; Serine; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins	2014
Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Archives of biochemistry and biophysics, 2014, Nov-15, Volume: 562 Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Hep G2 Cells; Hepatocytes; Humans; Insulin; Insulin-Like Growth Factor I; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; Sirolimus	2014
Phosphorylation of Atg31 is required for autophagy. Protein & cell, 2015, Volume: 6, Issue:4 Topics: Alanine; Amino Acid Motifs; Aspartic Acid; Autophagy; Autophagy-Related Proteins; Carrier Proteins; Gene Expression Regulation, Fungal; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Nitrogen; Phagosomes; Phosphorylation; Protein Transport; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Signal Transduction; Sirolimus	2015
mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress. Molecular cancer research : MCR, 2015, Volume: 13, Issue:10 Topics: Animals; Cell Line, Tumor; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Fibrosarcoma; Humans; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Phosphorylation; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection; Up-Regulation	2015
[Keratin 18 phosphorylation increases autophagy of colorectal cancer HCT116 cells and enhanced its sensitivity to oxaliplatin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2016, Volume: 32, Issue:1 Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Colorectal Neoplasms; Flow Cytometry; HCT116 Cells; Humans; Keratin-18; Microscopy, Fluorescence; Mutation; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Serine; Sirolimus; Transfection	2016
Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice. Neurobiology of aging, 2016, Volume: 46 Topics: Amyloid beta-Protein Precursor; Animals; Brain; CA1 Region, Hippocampal; Cytoplasm; Disease Models, Animal; DNA-Binding Proteins; Down Syndrome; Gene Expression; Histone Chaperones; Male; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; Oncogene Proteins; Phosphorylation; Protein Phosphatase 2; Protein Transport; Serine; Sirolimus; tau Proteins; Threonine	2016
Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer. Oncotarget, 2016, Sep-20, Volume: 7, Issue:38 Topics: AMP-Activated Protein Kinases; Androgen Receptor Antagonists; Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor alpha; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphorylation; Progesterone Reductase; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrans; Receptors, Androgen; Serine; Signal Transduction; Sirolimus; Steroid 17-alpha-Hydroxylase; Steroid Isomerases; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2016
The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer. Oncogene, 2017, 11-16, Volume: 36, Issue:46 Topics: Anilides; Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Eukaryotic Initiation Factor-4E; Everolimus; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice, Nude; Nitriles; Phosphorylation; Prostatic Neoplasms, Castration-Resistant; Protein Serine-Threonine Kinases; Purines; Receptors, Androgen; Serine; Sirolimus; TOR Serine-Threonine Kinases; Tosyl Compounds; Xenograft Model Antitumor Assays	2017
Hepatic phosphorylation status of serine/threonine kinase 1, mammalian target of rapamycin signaling proteins, and growth rate in Holstein heifer calves in response to maternal supply of methionine. Journal of dairy science, 2018, Volume: 101, Issue:9 Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Cattle; Diet; Female; Methionine; Phosphorylation; Pregnancy; Protein Serine-Threonine Kinases; Serine; Sirolimus	2018
In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition. Molecular cell, 2021, 01-21, Volume: 81, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Ketoglutaric Acids; Lung Neoplasms; Mammary Neoplasms, Experimental; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; Mice, Nude; Monocarboxylic Acid Transporters; Phosphoglycerate Dehydrogenase; Pyruvic Acid; RNA, Small Interfering; Serine; Signal Transduction; Sirolimus	2021
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Nucleic acids research, 2021, 04-06, Volume: 49, Issue:6 Topics: Amino Acid Motifs; Autoantigens; HEK293 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Naphthyridines; Phosphorylation; Protein Binding; Protein Biosynthesis; Ribonucleoproteins; Serine; Sirolimus; SS-B Antigen; Threonine; Tyrosine	2021
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions. Autophagy, 2022, Volume: 18, Issue:10 Topics: Actins; Adenosine; AMP-Activated Protein Kinases; Animals; Autophagy; Cadherins; Cathepsin D; Chloroquine; Endometrium; Epithelial-Mesenchymal Transition; Female; Fibronectins; Fibrosis; Iodide Peroxidase; Lipopolysaccharides; Lysosomal-Associated Membrane Protein 1; Mice; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Phosphates; Proto-Oncogene Proteins c-akt; Sequestosome-1 Protein; Serine; Sirolimus; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Triiodothyronine	2022
L-4-Fluorophenylglycine produces antidepressant-like effects and enhances resilience to stress in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 155 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems, Neutral; Animals; Antidepressive Agents; Depression; Hippocampus; Mammals; Mice; Mice, Inbred C57BL; Serine; Sirolimus; Stress, Psychological; TOR Serine-Threonine Kinases	2022
Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis. The Journal of biological chemistry, 2023, Volume: 299, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Growth Processes; Cell Line; Mechanistic Target of Rapamycin Complex 1; Mice; Morphogenesis; Phosphorylation; Regulatory-Associated Protein of mTOR; Serine; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors	2023