serine has been researched along with pyridoxal phosphate in 221 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 143 (64.71) | 18.7374 |
| 1990's | 22 (9.95) | 18.2507 |
| 2000's | 28 (12.67) | 29.6817 |
| 2010's | 21 (9.50) | 24.3611 |
| 2020's | 7 (3.17) | 2.80 |
| Authors | Studies |
|---|---|
| Reiber, H | 1 |
| Feldmann, K; Hull, WE | 1 |
| Inagaki, C; Tanaka, C | 1 |
| Araki, H; Inagaki, C; Ohmura, I; Tanaka, C | 1 |
| Carlson, GM; Carty, TJ; Graves, DJ; Parrish, RF; Skuster, JR; Tessmer, GW | 1 |
| Hayaishi, O; Shizuta, Y | 1 |
| Miles, EW | 3 |
| Feldmann, K; Helmreich, EJ; Hoerl, M; Schnackerz, KD | 1 |
| Anderson, WF; Katunuma, N; Kobayashi, K; Matthews, BW; Neurath, H; Titani, K; Woodbury, RG | 1 |
| Bhargava, A; Chauhan, YS; Garg, GK; Rathore, VS | 1 |
| Braunstein, AE; Goryachenkova, EV | 1 |
| Rando, RR | 1 |
| Fukushima, K; Masada, M; Tamura, G | 1 |
| DeMoss, RD; Fenske, JD | 1 |
| Kumagai, H; Yamada, H | 1 |
| Douce, R; Droux, M; Martin, J; Sajus, P | 1 |
| Cook, PF; Hara, S; Nalabolu, S; Schnackerz, KD | 1 |
| Paszkowski, A | 1 |
| Izumi, Y; Yamada, H; Yoshida, T | 1 |
| Niedzielska, A; Paszkowski, A | 1 |
| Luanvararat, M; O'Sullivan, WJ; Ruenwongsa, P | 1 |
| Brasch, MA; Snell, EE; Vaaler, GL | 1 |
| Kikuchi, G; Yoshida, T | 1 |
| Chatagner, F; de Billy, G; Ipaktchi, M; Lefauconnier, JM; Portemer, C | 1 |
| Bentley, CM; Dawes, EA | 1 |
| Suskind, SR; Tsai, H | 1 |
| Matchett, WH | 1 |
| Botsford, JL; Parks, LW | 1 |
| Kikuchi, G; Kochi, H; Sato, N; Sato, T | 1 |
| Fasella, P; John, RA | 1 |
| Brady, RN; Dimari, SJ; Snell, EE | 1 |
| Dempsey, WB; Ito, H | 1 |
| Dempsey, WB | 2 |
| Goriukhina, TA; Lebedeva, SB | 1 |
| Bruin, WJ; Frantz, BM; Sallach, HJ | 1 |
| Braun, PE; Snell, EE | 1 |
| Gräser, H | 1 |
| Kikuchi, G; Kochi, H | 1 |
| Braun, PE; Morell, P; Radin, NS | 1 |
| Turner, JM; Willetts, AJ | 1 |
| Lipsett, MN | 1 |
| Bridgers, WF; McClain, LD | 1 |
| York, SS | 1 |
| Elsässer, S; Holzer, H; Katsunuma, T; Schött, E | 1 |
| Balbinder, E; Dicamelli, RF; Lebowitz, J | 1 |
| Dempsey, WB; Tani, Y | 1 |
| Hayaishi, O; Inoue, K; Kurosawa, A; Shizuta, Y; Tanabe, T | 1 |
| Nakamura, KD; Parks, LW; Trewyn, RW | 1 |
| Kumagai, H; Miles, EW | 1 |
| McPhie, P; Miles, EW | 1 |
| Snell, EE | 1 |
| Thomas, P; Tudball, N | 1 |
| John, RA; Tudball, N | 1 |
| Blanck, TJ; Dunathan, HC; Hindenlang, DM; Kallen, RG; Ulevitch, RJ; Voet, JG | 1 |
| Ellegaard, J; Esmann, V | 1 |
| Conerly, EB; Mudd, SH; Uhlendorf, BW | 1 |
| Chen, MS; Edmiston, M; Schirch, LV | 1 |
| Florentiev, VL; Goryachenkova, EV; Polyakova, LA; Yefremova, LL | 1 |
| Beratis, NG; Fleisher, LD; Gaull, GE; Hirschhorn, K; Tallan, HH | 1 |
| Goldberg, ME; Raibaud, O | 1 |
| Cohn, MS; Phillips, AT | 1 |
| Baldwin, RL; Goldberg, ME | 1 |
| Crawford, IP; Hatanaka, M; Miles, EW | 1 |
| Goldberg, ME; Stryer, L; York, S | 1 |
| Fukui, S; Nakai, Y; Ohishi, N; Shimizu, S | 1 |
| Becker, MA; Kredich, NM; Tomkins, GM | 1 |
| Delmer, DP; Mills, S | 1 |
| Crawford, IP | 1 |
| Fischer, EH; Strausbauch, PH | 1 |
| Kumagai, H; Matsui, H; Ogata, K; Ohkishi, H; Yamada, H | 1 |
| Creighton, TE | 1 |
| Crawford, IP; Fluri, R; Jackson, LE; Lee, WE | 1 |
| Dunathan, HC | 1 |
| Conn, EE; Floss, HG; Hadwiger, L | 1 |
| Boyd, WL; Staley, JT | 1 |
| Crawford, IP; Maurer, R | 2 |
| Gupta, YP | 1 |
| Hathaway, GM | 1 |
| Martin, WG; Sass, NL | 1 |
| Hoshino, J; Kröger, H; Simon, D | 1 |
| Carter, JE; Sagers, RD | 1 |
| Broderick, DS; Candland, KL; Mangum, JH; North, JA | 1 |
| Nath, M; Sanwal, GG | 1 |
| Cheng, CF; Haslam, JL | 1 |
| Asmar, JA; Daghir, NJ; Sifri, M | 1 |
| Ebadi, M; Pfeiffer, R | 1 |
| Flavin, M; Posner, BI | 1 |
| Braunstein, AE; Goryachenkova, EV; Tolosa, EA; Willhardt, IH; Yefremova, LL | 1 |
| Creighton, TE; Yanofsky, C | 1 |
| Diven, WF; Johnston, MM | 1 |
| Akhtar, M; Jordan, PM | 1 |
| Abbott, EH; Martell, AE | 1 |
| Brock, BL; King, J; Wilkinson, DA | 1 |
| Kumagai, H; Nagate, T; Yamada, H; Yoshida, H | 1 |
| Gilmour, DG; Manowitz, P; Racevskis, J | 1 |
| Brown, MS; Edwards, WA; Laster, L; Loeb, PM; Mudd, SH | 1 |
| Thomas, JH; Tudball, N | 1 |
| Smith, IK; Thompson, JF | 1 |
| Diller, A; Schirch, LV | 1 |
| Giovanelli, J; Mudd, SH | 1 |
| Brown, FC; Gordon, PH | 1 |
| McLemore, WO; Metzler, DE | 1 |
| De Issaly, IS | 1 |
| Rabinowitz, JC; Uyeda, K | 1 |
| Flavin, M; Guggenheim, S | 1 |
| Kimura, H; Nakagawa, H | 1 |
| Dodgson, KS; Thomas, JH; Tudball, N | 1 |
| Bridgers, WF | 1 |
| Freedland, RA; Szepesi, B | 1 |
| Fowler, JA; Thmas, JH | 1 |
| Coghe, M; Fossa, T; Grillo, MA | 1 |
| Colonna, A; Grignani, F; Martelli, M; Tonato, M | 1 |
| Boll, M; Holzer, H | 1 |
| Belugina, OP; Paducheva, AL | 1 |
| Ikawa, M | 1 |
| Meister, A; Miles, EW | 1 |
| Kikuchi, G; Kochi, H; Motokawa, Y; Sato, T | 1 |
| Ireland, RJ; Joy, KW | 1 |
| Merrill, AH; Wang, E; Williams, RD | 1 |
| Bartholmes, P | 1 |
| Hinz, HJ; Wiesinger, H | 1 |
| Roise, D; Soda, K; Walsh, CT; Yagi, T | 1 |
| Kirschner, K; Tschopp, J | 1 |
| Korpela, TK; Mäkelä, MJ | 1 |
| Hoch, SO; Soldau, K | 1 |
| Korpela, T; Lönnberg, H; Mäkelä, M | 1 |
| Feldhaus, RW; Likos, JJ; Metzler, DE; Ueno, H | 1 |
| Cook, PF; Jacobson, TM; Nalabolu, SR; Simmons, JW; Tai, CH | 1 |
| Ahmed, SA; Banik, U; Miles, EW; Parris, KD; Ruvinov, SB; Sackett, DL; Yang, XJ | 1 |
| Bukovska, G; Kery, V; Kraus, JP | 1 |
| Cook, PF; McClure, GD | 1 |
| Winkler, ME; Zhao, G | 1 |
| Bettati, S; Dunn, MF; Miles, EW; Mozzarelli, A; Peracchi, A; Rossi, GL | 1 |
| Misono, H; Nagata, S; Okuda, H | 1 |
| Bertoldi, M; Castellani, S; Dominici, P; Moore, PS; Voltattorni, CB | 1 |
| Chait, BT; Erickson, SD; Haller, I; Manning, JM; Martinez del Pozo, A; Petsko, G; Ringe, D; Soda, K; van Ophem, PW; Yoshimura, T | 1 |
| Ahmed, SA; Jhee, KH; McPhie, P; Miles, EW; Rowlett, R; Yang, LH | 1 |
| Esaki, N; Shimizu, S; Uo, T; Yoshimura, T | 1 |
| Bossa, F; De Biase, D; Delle Fratte, S; di Salvo, ML; Schirch, V | 1 |
| Jhee, KH; McPhie, P; Miles, EW; Ro, HS | 1 |
| Brady, RO; Ferris, CD; Mothet, JP; Sheth, KN; Snyder, SH; Takahashi, M; Wolosker, H | 1 |
| Banerjee, R; Taoka, S; West, M | 1 |
| Banerjee, R; Taoka, S; Widjaja, L | 1 |
| Ro, HS; Wilson Miles, E | 1 |
| Cuskelly, GJ; Gregory, JF; Martinez, M; Toth, JP; Williamson, J | 1 |
| Prakash, V; Rao, JV; Rao, NA; Savithri, HS | 1 |
| Bruno, S; Burkhard, P; Janosik, M; Kraus, JP; Mozzarelli, A; Schiaretti, F | 1 |
| Banerjee, R; Kabil, O; LoBrutto, R; Shoemaker, R; Toaka, S | 1 |
| Basset, G; Hanson, AD; Nishida, I; Rontein, D; Tashiro, G; Voelker, DR; Wu, WI; Yoshioka, K | 1 |
| Dunn, MF; Jhee, KH; McPhie, P; Miles, EW; Niks, D | 1 |
| Cook, PF; Karsten, WE | 1 |
| Arac, D; Dunn, MF; Kulik, V; Niks, D; Schlichting, I; Seidel, R; Weyand, M | 1 |
| Cook, PF; Daum, S; Tai, CH | 1 |
| Hilvert, D; Seebeck, FP | 1 |
| AZARKH, RM; BRAUNSHTEIN, AE | 1 |
| BLAKLEY, RL | 2 |
| DELAVIER-KLUTCHKO, C; FLAVIN, M; SLAUGHTER, C | 1 |
| FROMAGEOT, P; POUZAT, J; RODERICK, UR | 1 |
| HARRINGTON, H; SAKAMI, W | 1 |
| NAIR, PM; VAIDYANATHAN, CS | 1 |
| LANGER, BW | 1 |
| NEWTON, WA; SNELL, EE | 1 |
| CRAWFORD, IP; ITO, J | 1 |
| DOBSON, MB; DURHAM, NN; FERGUSON, D; KUDLAC, JJ | 1 |
| FLAVIN, M; SLAUGHTER, C | 1 |
| FLAVIN, M; SEGAL, A | 1 |
| FROMAGEOT, P; SENTENAC, A | 1 |
| DURHAM, NN; FERGUSON, D; JACOBS, CD | 1 |
| AXELROD, AE; TRAKATELLIS, AC | 1 |
| Komoto, J; Ogawa, H; Pitot, HC; Takata, Y; Takusagawa, F; Yamada, T | 1 |
| REISSIG, JL | 1 |
| Coats, BS; Davis, SR; Gregory, JF; Quinlivan, EP; Scheer, JB; Stacpoole, PW | 1 |
| Feld, J; Kang, Y; Neary, JT; Tran, M | 1 |
| Goody, RS; Holtermann, G; Miles, EW; Phillips, RS | 1 |
| Bonner, ER; Cahoon, RE; Jez, JM; Knapke, SM | 1 |
| Fujitani, Y; Ishihara, K; Ito, K; Nakajima, N; Oikawa, T; Sugimoto, M | 1 |
| Amoreira, C; Baldridge, KK; Guainazzi, A; Hilvert, D; Seebeck, FP | 1 |
| Kasuya, T; Komoto, J; Mori, H; Ogawa, H; Takata, Y; Takusagawa, F; Yamada, T | 1 |
| Banerjee, R; Lin, A; Zhu, W | 1 |
| Yoshimura, T | 1 |
| Goto, M; Yoshimura, T | 1 |
| Rodríguez-Crespo, I | 1 |
| Ko, TP; Lee, CY; Wang, NC | 1 |
| Appaji Rao, N; Bhavani, BS; Bisht, S; Kaul, P; Murthy, MR; Prakash, V; Rajaram, V; Savithri, HS | 1 |
| Bowman, J; Gujjar, R; Hunter, JH; Mudeppa, DG; Pang, CK; Podutoori, R; Rathod, PK | 1 |
| Kuzuyama, T; Miyagawa, T; Nishiyama, M; Ouchi, T; Tomita, T | 1 |
| Ichiyama, A; Mugiya, S; Nagata, M; Oda, T; Ozono, S; Takayama, T | 1 |
| Liu, G; Liu, J; Nie, L; Qian, L; Wang, Z; Zheng, C | 1 |
| Barker, J; Cesura, A; Ebneth, A; Felicetti, B; Mack, V; Mather, O; Moraes, I; Schonfeld, D; Smith, MA; Wood, M | 1 |
| Carrasquero, LM; Delicado, EG; Iglesias, T; Miras-Portugal, MT; Sánchez-Ruiloba, L | 1 |
| Copley, SD; Kershner, JP; Kim, J; Novikov, Y; Shoemaker, RK | 1 |
| Ota, N; Romanova, EV; Sweedler, JV; Wang, L | 1 |
| Horiike, K; Ishida, T; Murakami, M; Nagata, Y; Suzuki, C; Tanaka, H; Yokobori, H | 1 |
| Baldassarre, M; Scirè, A; Tanfani, F | 1 |
| Adrover, M; Caldés, C; Donoso, J; Gallardo, JM; Muñoz, F; Ortega-Castro, J; Vilanova, B | 1 |
| Goto, M; Hayashi, S; Hemmi, H; Ito, T; Maekawa, M; Maki, M; Murase, H; Saito, H; Yoshimura, T | 1 |
| D'Auria, S; Dell'Angelo, V; Di Giovanni, S; di Mase, DS; Labella, T; Pellecchia, C; Ruggiero, G; Staiano, M; Strianese, M; Varriale, A | 1 |
| Ambili, M; Jala, VR; Prakash, V; Rao, NA; Savithri, HS | 1 |
| Beattie, AE; Campopiano, DJ; Clarke, DJ; Lowther, J; Sin, HL; Wadsworth, JM | 1 |
| Chi, YY; Coats, B; da Silva, VR; Garrett, TJ; Gregory, JF; Lamers, Y; Midttun, Ø; Muller, KE; Percival, SS; Quinlivan, EP; Ralat, MA; Rios-Avila, L; Shankar, MN; Stacpoole, PW; Ueland, PM | 1 |
| Hemmi, H; Ito, T; Koga, K; Matsuoka, M; Yoshimura, T | 1 |
| Major, DT; Nitoker, N | 1 |
| Ahmed, MH; Chowdhury, N; Contestabile, R; di Salvo, ML; Gandhi, A; Ghatge, MS; Kellogg, GE; Musayev, FN; Remesh, SG; Safo, MK; Schirch, V | 1 |
| Gruber, K; Mink, D; Oberdorfer, G; Riegler-Berket, L; Schürmann, M; Steinkellner, G; Uhl, MK; van Assema, F | 1 |
| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Ralat, M; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
| Abe, K; Akagi, Y; Dehara, Y; Mizobata, K; Moe, LA; Radkov, AD; Saigan, M; Sogawa, N; Uda, K | 1 |
| Genchi, G | 1 |
| Burgering, B; Gerrits, J; Jans, JJ; Pras-Raves, ML; Prinsen, H; Ramos, RJ; van der Ham, M; Verhoeven-Duif, NM; Willemsen, M | 1 |
| Gleeson, D; Gleeson, MP; Santatiwongchai, J | 1 |
| Gong, X; Li, S; Liu, P; Wang, L; Xie, T | 1 |
| Hakamata, M; Hemmi, H; Ito, T; Saito, C; Sezutsu, H; Sumitani, M; Tanaka, Y; Yoshimura, T | 1 |
| Bingman, CA; Buller, AR; Harrison, IM; Smith, JL | 1 |
| El Baze, A; Knizia, D; Lakhssassi, A; Lakhssassi, N; Meksem, J; Meksem, K | 1 |
| Goto, H; Ikushiro, H; Kamiya, N; Katayama, A; Miyahara, I; Murakami, T; Sawai, T; Takahashi, A; Yano, T | 1 |
| Bettati, S; Bianchera, A; Bruno, S; Campanini, B; Cavazzini, D; Marchesani, F; Michielon, A; Mozzarelli, A; Murtas, G; Peracchi, A; Pollegioni, L; Viale, E | 1 |
| Gao, J; Hai, Y; Zhou, C | 1 |
10 review(s) available for serine and pyridoxal phosphate
| Article | Year |
|---|---|
Regulation of biodegradative threonine deaminase.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Amino Acid Sequence; Butyrates; Clostridium; Cyclic AMP; Enzyme Activation; Escherichia coli; Glucose; Hydro-Lyases; Keto Acids; Kinetics; Models, Biological; Molecular Conformation; Molecular Weight; Oxygen; Pyridoxal Phosphate; Pyruvates; Serine; Threonine; Threonine Dehydratase | 1976 |
The pyridoxal-phosphate-dependent enzymes exclusively catalyzing reactions of beta-replacement.
Topics: Amino Acids; Animals; Carboxy-Lyases; Chick Embryo; Chloromercuribenzoates; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Cystine; Kinetics; Lyases; Nitriles; Pyridoxal Phosphate; Rats; Serine; Sulfhydryl Compounds; Thiocyanates | 1976 |
Some interrelationships of pyridoxal phosphate, folic acid, and serine metabolism in brain.
Topics: Animals; Brain; Cell Fractionation; Centrifugation, Density Gradient; Folic Acid; Mice; Mitochondria; Organ Size; Pyridoxal Phosphate; Rats; Serine; Synaptosomes; Transferases | 1972 |
Relation of chemical structure to metabolic activity of vitamin B 6 .
Topics: Animals; Apoproteins; Aspartate Aminotransferases; Body Weight; Catalysis; Chemical Phenomena; Chemistry; Enterococcus faecalis; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Pyridoxal Phosphate; Pyridoxine; Pyruvates; Rats; Serine; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays | 1972 |
[Tryptophan synthetase of . coli. Recent studies on the beta-2 subunits].
Topics: Electrophoresis; Escherichia coli; Genes; Genetics, Microbial; Hydro-Lyases; Mutation; Pyridoxal Phosphate; Serine; Tryptophan | 1969 |
Stereochemical aspects of pyridoxal phosphate catalysis.
Topics: 5-Aminolevulinate Synthetase; Alanine Transaminase; Allosteric Regulation; Amino Acids; Aspartic Acid; Binding Sites; Carboxy-Lyases; Catalysis; Cystathionine; Glycine; Homoserine; Kinetics; Lyases; Models, Biological; Molecular Conformation; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Schiff Bases; Serine; Structure-Activity Relationship; Threonine; Transaminases; Transferases | 1971 |
AMINO ACID METABOLISM.
Topics: Amino Acid Oxidoreductases; Amino Acids; Carboxy-Lyases; Glutamates; Glycine; Hydroxyproline; Lysine; Peroxidases; Phenylalanine; Proline; Proteins; Pyridoxal Phosphate; Research; Serine; Threonine; Transaminases; Tryptophan; Tyrosine; Urea | 1963 |
[Structure and function of amino acid racemases].
Topics: Alanine Racemase; Amino Acid Isomerases; Amino Acids; Animals; Brain; Isomerism; Protein Conformation; Pyridoxal Phosphate; Racemases and Epimerases; Serine | 2008 |
D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases.
Topics: Alanine Racemase; Amino Acid Isomerases; Animals; Bacteria; Brain; Isomerism; Pyridoxal Phosphate; Racemases and Epimerases; Serine | 2008 |
An overview on D-amino acids.
Topics: Amino Acid Isomerases; Amphibian Venoms; Animals; Antimicrobial Cationic Peptides; Bacteria; D-Amino-Acid Oxidase; D-Aspartic Acid; Diet; Glyceraldehyde; Humans; Plants; Pyridoxal Phosphate; Schiff Bases; Serine; Stereoisomerism | 2017 |
211 other study(ies) available for serine and pyridoxal phosphate
| Article | Year |
|---|---|
Vitamin B-6-catalyzed beta-elimination of serine and O-phosphoserine. Qualitative and quantitative aspects of catalytic influences at the rate-limiting step, a comparison with the rate of enzymatic beta-elimination.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mathematics; Organophosphorus Compounds; Pyridoxal Phosphate; Schiff Bases; Serine | 1976 |
31P nuclear magnetic resonance studies of glycogen phosphorylase from rabbit skeletal muscle: ionization states of pyridoxal 5'-phosphate.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Allosteric Regulation; Animals; Arsenates; Binding Sites; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Ligands; Magnetic Resonance Spectroscopy; Muscles; Phosphorylases; Protein Conformation; Pyridoxal Phosphate; Rabbits; Serine | 1977 |
Characteristics of enzymic decarboxylation of L-threo-3,4-dihydroxyphenylserine using hog renal L-aromatic amino acid decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Decarboxylation; Dopa Decarboxylase; Droxidopa; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kinetics; Pyridoxal Phosphate; Serine; Stereoisomerism; Swine; Temperature; Time Factors | 1978 |
Enzymatic decarboxylation of L-threo-3,4-dihydroxyphenylserine in rat heart.
Topics: Animals; Carboxy-Lyases; Decarboxylation; Dihydroxyphenylalanine; Droxidopa; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Myocardium; Norepinephrine; Pyridoxal Phosphate; Pyrogallol; Rats; Serine; Temperature; Time Factors | 1978 |
Pyridoxal phosphate-dependent conformational states of glycogen phosphorylase as probed by interconverting enzymes.
Topics: Apoenzymes; Glucose; Glucosephosphates; Kinetics; Muscles; Phosphoric Monoester Hydrolases; Phosphorylase Kinase; Phosphorylases; Protein Conformation; Protein Kinases; Pyridoxal Phosphate; Serine; Structure-Activity Relationship; Trypsin | 1975 |
Effects of modification of the beta 2 subunit and of the alpha2beta2 complex of tryptophan synthase by alpha-cyanoglycine, a substrate analog.
Topics: Catalysis; Dialysis; Enzyme Activation; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Mathematics; Nitriles; Pyridoxal Phosphate; Serine; Spectrophotometry; Temperature; Tryptophan Synthase; Urea | 1975 |
Ionization of pyridoxal 5'-phosphate and the interactions of AMP-S and thiophosphoseryl residues in native and succinylated rabbit muscle glycogen phosphorylase b and a as inferred from 31P NMR spectra.
Topics: Adenosine Monophosphate; Anhydrides; Animals; Binding Sites; Magnetic Resonance Spectroscopy; Muscles; Phosphorylase a; Phosphorylase b; Phosphorylases; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Rabbits; Serine; Succinates; Thionucleotides | 1979 |
Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine.
Topics: Amino Acid Sequence; Amino Acids; Animals; Apoenzymes; Binding Sites; Biological Evolution; Chymotrypsin; Disulfides; Endopeptidases; Intestine, Small; Peptide Fragments; Pyridoxal Phosphate; Rats; Serine; Serine Endopeptidases; Trypsin; X-Ray Diffraction | 1978 |
Detection of an indole oxidizing system in maize leaves.
Topics: Chelating Agents; Copper; Indoles; Oxidation-Reduction; Oxygenases; Pyridoxal Phosphate; Serine; Tryptophan; Zea mays | 1978 |
On the mechanism of action of antibiotics which act as irreversible enzyme inhibitors.
Topics: Alanine; Anti-Bacterial Agents; Asparagine; Azaserine; Azo Compounds; Carbamates; Catalysis; Cell Wall; Cephalosporins; Cycloserine; Diazooxonorleucine; Enzyme Inhibitors; Glutamine; Models, Chemical; Models, Molecular; Penicillins; Purines; Pyridoxal Phosphate; Pyrimidines; Racemases and Epimerases; Serine | 1975 |
Cysteine synthase from rape leaves.
Topics: Chromatography, Gel; Cysteine; Kinetics; Lyases; Macromolecular Substances; Molecular Weight; Plants; Protein Conformation; Pyridoxal Phosphate; Serine; Subcellular Fractions | 1975 |
Substrate-protein interaction in tryptophanase from Bacillus alvei. Kinetic and spectral evaluations.
Topics: Amino Acids; Bacillus; Binding Sites; Binding, Competitive; Circular Dichroism; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Kinetics; Lyases; Mathematics; Models, Molecular; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tryptophanase | 1975 |
Synthesis of L-tyrosine-related amino acids by beta-tyrosinase.
Topics: Amino Acids; Ammonia; Catalysis; Catechols; Cell-Free System; Chemical Phenomena; Chemistry; Crystallization; Dihydroxyphenylalanine; Enzyme Induction; Erwinia; Escherichia; Lyases; Molecular Weight; Phenols; Pyridoxal Phosphate; Pyruvates; Sepharose; Serine; Stereoisomerism; Tyrosine; Tyrosine Phenol-Lyase | 1975 |
Purification and characterization of O-acetylserine (thiol) lyase from spinach chloroplasts.
Topics: Acetyltransferases; Amino Acids; Blotting, Western; Chloroplasts; Chromatography, Liquid; Cross Reactions; Cysteine; Cysteine Synthase; Electrophoresis, Polyacrylamide Gel; Epitopes; Mitochondria; Plants; Pyridoxal Phosphate; Serine; Serine O-Acetyltransferase; Spectrometry, Fluorescence | 1992 |
pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Topics: Acetylation; Binding Sites; Cysteine Synthase; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Serine; Spectrophotometry; Substrate Specificity | 1992 |
Some properties of serine: glyoxylate aminotransferase from rye seedlings (Secale cereale L.).
Topics: Binding Sites; Binding, Competitive; Formaldehyde; Glyoxylates; Kinetics; Plants; Pyridoxal Phosphate; Secale; Serine; Substrate Specificity; Sulfhydryl Reagents; Transaminases | 1991 |
Purification and characterization of serine-glyoxylate aminotransferase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2.
Topics: Bacteria; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Glyoxylates; Kinetics; Molecular Weight; Pyridoxal Phosphate; Serine; Spectrophotometry; Substrate Specificity; Transaminases | 1990 |
Serine:glyoxylate aminotransferase from the seedlings of rye (Secale cereale L.).
Topics: Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Glyoxylates; Hydrogen-Ion Concentration; Mercaptoethanol; Molecular Weight; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Secale; Seeds; Serine; Substrate Specificity; Sucrose; Transaminases | 1990 |
Serine hydroxymethyltransferase from pyrimethamine-sensitive and -resistant strains of Plasmodium chabaudi.
Topics: Animals; Drug Resistance; Glycine Hydroxymethyltransferase; Hydrogen-Ion Concentration; Kinetics; Plasmodium; Pyridoxal Phosphate; Pyrimethamine; Serine; Temperature; Tetrahydrofolates; Transferases | 1989 |
Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Nucleotide sequence of the hdc gene and the corresponding amino acid sequence.
Topics: Amino Acid Sequence; Base Sequence; Carboxy-Lyases; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; Genes; Histidine Decarboxylase; Protein Conformation; Proteus; Pyridoxal Phosphate; Serine | 1986 |
Significance of the glycine cleavage system in glycine and serine catabolism in avian liver.
Topics: Ammonium Chloride; Animals; Arylformamidase; Bicarbonates; Carbon Dioxide; Carbon Isotopes; Chickens; Columbidae; Cycloserine; Cysteine; Enzyme Activation; Folic Acid; Glycine; Hydroxylamines; Hypoxanthines; L-Serine Dehydratase; Liver; Male; Mitochondria, Liver; NAD; NADP; Oxidoreductases; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Semicarbazides; Serine; Species Specificity; Subcellular Fractions; Transferases; Uric Acid | 1971 |
Redistribution of pyridoxal phosphate in the male rat liver as a result of repeated injections of hydrocortisone.
Topics: Alanine Transaminase; Animals; Aspartic Acid; Carboxy-Lyases; Cystathionine; Cysteine; Dose-Response Relationship, Drug; Homocysteine; Homoserine; Hydro-Lyases; Hydrocortisone; L-Serine Dehydratase; Liver; Lyases; Male; Pyridoxal Phosphate; Rats; Seasons; Serine; Time Factors; Tyrosine Transaminase | 1973 |
The energy-yielding reactions of Peptococcus prévotii, their behaviour on starvation and the role and regulation of threonine dehydratase.
Topics: Acyltransferases; Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Anaerobiosis; Binding Sites; Energy Metabolism; Hot Temperature; Hydro-Lyases; Hydrogen-Ion Concentration; Keto Acids; Kinetics; L-Serine Dehydratase; NADH, NADPH Oxidoreductases; Nitrogen; Oxidation-Reduction; Peptococcus; Pyridoxal Phosphate; Serine; Starvation; Threonine | 1974 |
Enzymic properties of a mutant tryptophan synthase from Neurospora crassa.
Topics: Apoproteins; Buffers; Catalysis; Chromatography; Colorimetry; Drug Stability; Enzyme Activation; Genetics, Microbial; Hot Temperature; Hydro-Lyases; Hydroxyapatites; Indoles; Mutation; Neurospora; Neurospora crassa; Protamines; Pyridoxal Phosphate; Serine; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry; Sulfonic Acids; Tryptophan Synthase | 1972 |
Indole channeling by tryptophan synthase of neurospora.
Topics: Binding Sites; Biological Evolution; Carbon Radioisotopes; Glycerophosphates; Indoles; Kinetics; Mathematics; Neurospora; Neurospora crassa; Pyridoxal Phosphate; Serine; Time Factors; Tryptophan; Tryptophan Synthase | 1974 |
Role of S-adenosylmethionine in methionine biosynthesis in yeast.
Topics: Adenine Nucleotides; Carbon Isotopes; Cell-Free System; Culture Media; Escherichia coli; Ethanol; Flavin-Adenine Dinucleotide; Hexosephosphates; Homocysteine; Magnesium; Methionine; NAD; Nucleosides; Pyridoxal Phosphate; Saccharomyces; Serine | 1967 |
Glycine metabolism by rat liver mitochondria. 3. The glycine cleavage and the exchange of carboxyl carbon of glycine with bicarbonate.
Topics: Ammonia; Animals; Arsenic; Bicarbonates; Carbon Dioxide; Carbon Isotopes; Folic Acid; Glycine; In Vitro Techniques; Kinetics; Mitochondria, Liver; NAD; Pyridoxal Phosphate; Rats; Serine; Sulfhydryl Compounds; Transferases | 1969 |
The reaction of L-serine O-sulfate with aspartate aminotransferase.
Topics: Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Binding Sites; Chemical Phenomena; Chemistry; Dialysis; Fluorometry; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Malates; Myocardium; NAD; Protons; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Spectrophotometry; Sulfates; Swine | 1969 |
Biosynthesis of sphingosine and dihydrosphingosine by cell-free systems from Hansenula ciferri.
Topics: Carbon Isotopes; Cell-Free System; Chromatography; Chromatography, Gas; Coenzyme A; Gels; Ketones; Lipids; Palmitic Acids; Pyridoxal Phosphate; Serine; Silicon Dioxide; Yeasts | 1970 |
Characterization of pyridoxine auxotrophs of Escherichia coli: serine and pdxF mutants.
Topics: Culture Media; Densitometry; Escherichia coli; Genetics, Microbial; Glycerolphosphate Dehydrogenase; Mutation; Phenotype; Phosphoric Monoester Hydrolases; Pyridoxal Phosphate; Pyridoxine; Serine; Transaminases | 1970 |
One-carbon metabolism and pyridoxal 5'-phosphate biosynthesis.
Topics: Carbon; Carbon Isotopes; Chromatography; Escherichia coli; Mutation; Phosphoric Monoester Hydrolases; Phosphorus; Pyridoxal Phosphate; Serine | 1970 |
[Isoenzyme spectrum of serine transoxymethylase in the liver and in hepatomas].
Topics: Agar; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Electrophoresis; Gels; Glycine; Isoenzymes; Liver; Liver Neoplasms; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Proteins; Pyridoxal Phosphate; Rats; Serine; Spectrophotometry; Tetrahydrofolates; Transferases | 1973 |
The occurrence of a glycine cleavage system in mammalian brain.
Topics: Animals; Brain; Carbon Dioxide; Carbon Isotopes; Cats; Cattle; Digitonin; Dithiothreitol; Dogs; Enzyme Activation; Glycine; Male; Mitochondria; Multienzyme Complexes; NAD; Pyridoxal Phosphate; Rabbits; Rats; Serine; Subcellular Fractions; Swine; Tetrahydrofolates | 1973 |
The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri.
Topics: Aldehydes; Amino Alcohols; Ascomycota; Carbon Isotopes; Chromatography, Thin Layer; Coenzyme A; Lipids; NADP; Palmitic Acids; Pyridoxal Phosphate; Serine | 1967 |
[The cofactors of serine synthesis in primary root homogenates of Zea mays].
Topics: Adenosine Triphosphate; Biotin; Buffers; Chromatography; Electrophoresis; Folic Acid; NADP; Poaceae; Pyridoxal Phosphate; Serine; Vitamin B 12 | 1966 |
Reactions of glycine synthesis and glycine cleavage catalyzed by extracts of Arthrobacter globiformis grown on glycine.
Topics: Ammonium Chloride; Arthrobacter; Bicarbonates; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Folic Acid; Formaldehyde; Glutathione; Glycine; Ion Exchange Resins; Kinetics; Mitochondria, Liver; NAD; NADP; Pyridoxal Phosphate; Serine; Sulfhydryl Compounds | 1969 |
Synthesis of C18- and C20-dihydrosphingosines, ketodihydrosphingosines, and ceramides by microsomal preparations from mouse brain.
Topics: Amino Alcohols; Animals; Autoradiography; Borates; Brain; Carbon Isotopes; Cerebrosides; Chromatography, Thin Layer; Coenzyme A; Ketones; Lipids; Methods; Mice; Microsomes; NADP; Palmitic Acids; Pyridoxal Phosphate; Serine; Stearic Acids | 1970 |
L-Threonine acetaldehyde-lyase in a strain of Bacillus subtilis.
Topics: Acetates; Aldehyde-Lyases; Bacillus subtilis; Carboxy-Lyases; Chromatography, Gel; Folic Acid; Glycine; Hydrazines; Hydrogen-Ion Concentration; Isoniazid; Kinetics; L-Serine Dehydratase; NAD; NADP; Phosphoric Acids; Pyridoxal Phosphate; Serine; Stereoisomerism; Threonine; Transferases | 1971 |
Biosynthesis of 4-thiouridylate. Participation of a sulfurtransferase containing pyridoxal 5'-phosphate.
Topics: Alanine; Aldehydes; Borohydrides; Chromatography; Cysteine; Enzyme Activation; Escherichia coli; Hydroxyapatites; Hydroxylamines; Kinetics; Organophosphorus Compounds; Picolines; Pyridoxal Phosphate; Pyruvates; RNA, Transfer; Serine; Sulfhydryl Compounds; Sulfur Isotopes; Sulfurtransferases; Thiouridine; Uridine | 1972 |
Incorporation of radioactivity into pyridoxal phosphate by Escherichia coli B.
Topics: Acetates; Amino Acids; Bicarbonates; Biological Assay; Borohydrides; Carbon Isotopes; Chromatography, Ion Exchange; Escherichia coli; Formates; Glucose; Glutamates; Hydrolysis; Methods; Oxidation-Reduction; Pyridoxal Phosphate; Pyridoxine; Pyruvates; Serine; Yeasts | 1972 |
Kinetic spectroscopic studies of substrate and subunit interactions of tryptophan synthetase.
Topics: Alcohols; Catalysis; Cysteine; Deamination; Escherichia coli; Hydro-Lyases; Kinetics; Macromolecular Substances; Mercaptoethanol; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Serine; Spectrometry, Fluorescence; Spectrophotometry; Tryptophan Synthase | 1972 |
Purification and properties of tryptophan-synthase-inactivating enzymes from yeast.
Topics: Alcohol Oxidoreductases; Apoproteins; Aspartate Aminotransferases; Cell Fractionation; Chromatography, Ion Exchange; Glucosephosphate Dehydrogenase; Hexokinase; Hot Temperature; Hydro-Lyases; Kinetics; Peptide Hydrolases; Protein Denaturation; Pyridoxal Phosphate; Saccharomyces; Saccharomyces cerevisiae; Serine; Threonine; Tryptophan Synthase | 1972 |
Reaction of 5 -pyridoxal methyl chloride, an analog of pyridoxal 5'-phosphate, with the B protein of Escherichia coli tryptophan synthetase.
Topics: Amino Acids; Apoproteins; Bacterial Proteins; Binding Sites; Chlorine; Circular Dichroism; Electrophoresis, Paper; Escherichia coli; Hydro-Lyases; Imines; Macromolecular Substances; Naphthols; Optical Rotation; Picolines; Pyridoxal; Pyridoxal Phosphate; Pyridoxine; Serine; Spectrometry, Fluorescence; Spectrophotometry; Tryptophan Synthase | 1972 |
Pressure effects on the association of the and 2 subunits of tryptophan synthetase from Escherichia coli and Salmonella typhimurium.
Topics: Binding Sites; Calcium; Cations, Divalent; Cations, Monovalent; Centrifugation, Density Gradient; Chlorides; Escherichia coli; Ethanol; Hydro-Lyases; Magnesium; Peptides; Pressure; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Salmonella typhimurium; Serine; Sodium; Spectrophotometry, Ultraviolet; Temperature; Tryptophan Synthase | 1973 |
Glycolaldehyde is a precursor of pyridoxal phosphate in Escherichia coli B.
Topics: Aldehydes; Carbon Radioisotopes; Escherichia coli; Glycols; Mutation; Pyridoxal Phosphate; Pyridoxine; Serine | 1973 |
Regulation of biodegradative threonine deaminase. 3. Effects of beta substituents of substrate on absorption spectrum and circular dichroism of the enzyme-bound pyridoxal phosphate.
Topics: Alanine; Binding Sites; Chlorine; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Circular Dichroism; Escherichia coli; Hydro-Lyases; Hydroxylation; Kinetics; Molecular Conformation; Protein Binding; Pyridoxal Phosphate; Schiff Bases; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Threonine; Time Factors; Valine | 1974 |
Purification and characterization of serine transhydroxy-methylase from Saccharomyces cerevisiae.
Topics: Carbon Radioisotopes; Cations, Divalent; Cations, Monovalent; Chromatography, Gel; Chromatography, Ion Exchange; Drug Stability; Electrophoresis, Disc; Glycerol; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Protamines; Pyridoxal Phosphate; Saccharomyces cerevisiae; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Tetrahydrofolates; Transferases | 1973 |
Evidence that the essential, photosensitive histidyl residue in the beta2 subunit of tryptophan synthetase is in the pyridoxyl peptide.
Topics: Amino Acid Sequence; Amino Acids; Binding Sites; Chromatography, Gel; Chromatography, Paper; Electrophoresis, Paper; Escherichia coli; Histidine; Peptide Fragments; Photochemistry; Protein Binding; Pyridoxal; Pyridoxal Phosphate; Serine; Spectrophotometry, Ultraviolet; Trypsin; Tryptophan Synthase | 1974 |
Modification of essential histidyl residues of the beta 2 subunit of tryptophan synthetase by photo-oxidation in the presence of pyridoxal 5'-phosphate and L-serine and by diethylpyrocarbonate.
Topics: Amino Acids; Enzyme Activation; Escherichia coli; Esters; Formates; Histidine; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; Macromolecular Substances; Models, Chemical; Oxidation-Reduction; Photochemistry; Protein Binding; Protons; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Schiff Bases; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Time Factors; Tryptophan Synthase | 1974 |
Evidence for a rate-determining proton abstraction in the serine deaminase reaction of the beta 2 subunit of tryptophan synthetase.
Topics: Deuterium; Escherichia coli; Kinetics; L-Serine Dehydratase; Macromolecular Substances; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mathematics; Models, Chemical; Protons; Pyridoxal Phosphate; Schiff Bases; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan Synthase | 1974 |
The enzymic degradation of L-serine O-sulphate. Mechanism of the reaction.
Topics: Ammonia-Lyases; Animals; Hydrogen-Ion Concentration; Liver; Methane; Nitro Compounds; Oxidation-Reduction; Photolysis; Protons; Pyridoxal Phosphate; Serine; Sulfuric Acids; Swine; Time Factors; Tritium; Water | 1972 |
Evidence for induced fit of a pseudo-substrate of aspartate aminotransferase.
Topics: Alanine; Animals; Aspartate Aminotransferases; Binding Sites; Catalysis; Chemical Phenomena; Chemistry; Chlorine; Copper; Cytoplasm; Depression, Chemical; Formates; Glutamates; Kinetics; Myocardium; Pyridoxal Phosphate; Serine; Stimulation, Chemical; Sulfuric Acids; Swine | 1972 |
The stereochemistry of pyridoxal phosphate enzymes. The absolute stereochemistry of cofactor C' 4 protonation in the transamination of holoserine hydroxymethylase by D-alanine.
Topics: Alanine; Aldehydes; Amination; Amino Acids; Animals; Chemical Phenomena; Chemistry; Glycine; Isomerism; Liver; Phosphoric Acids; Protons; Pyridoxal Phosphate; Pyridoxamine; Pyruvates; Serine; Sheep; Tetrahydrofolates; Transaminases; Transferases; Tritium | 1973 |
Folate activity of human lymphocytes determined by measurement of serine synthesis.
Topics: Carbon Dioxide; Carbon Isotopes; Chromatography, Thin Layer; Citric Acid Cycle; Folic Acid; Folic Acid Deficiency; Formates; Glucose; Glycine; Humans; In Vitro Techniques; Lymphocytes; Methionine; Methods; Protein Binding; Pyridoxal Phosphate; RNA; Serine; Tetrahydrofolates | 1973 |
Homocystinuria: studies in tissue culture.
Topics: Culture Techniques; Fibroblasts; Heterozygote; Homocysteine; Homocystine; Homocystinuria; Humans; Hydro-Lyases; L-Serine Dehydratase; Methionine; Methyltransferases; Oxidoreductases; Parents; Proteins; Pyridoxal Phosphate; Pyridoxine; Serine; Skin; Stimulation, Chemical; Tetrahydrofolates | 1973 |
Serine transhydroxymethylase. Subunit structure and the involvement of sulfhydryl groups in the activity of the enzyme.
Topics: Amino Acid Sequence; Amino Acids; Animals; Apoproteins; Benzoates; Chromatography, Gel; Chromatography, Paper; Disulfides; Dithiothreitol; Electrophoresis, Disc; Kinetics; Liver; Nitro Compounds; Oxidation-Reduction; Peptides; Protein Conformation; Protein Denaturation; Pyridoxal Phosphate; Rabbits; Serine; Spectrophotometry; Sulfhydryl Compounds; Sulfhydryl Reagents; Time Factors; Transferases | 1973 |
Interaction of pyridoxal phosphate analogues with apoenzymes of gamma-cystathionase and serine sulphhydrase.
Topics: Animals; Apoproteins; Binding Sites; Borohydrides; Chickens; Circular Dichroism; Cystathionine; Homocysteine; Hydro-Lyases; Hydrogen Sulfide; Kinetics; Liver; Lyases; Methylation; Penicillamine; Protein Binding; Pyridoxal Phosphate; Rats; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1973 |
Cystathionine synthase deficiency: heterozygote detection using cultured skin fibroblasts.
Topics: Amino Acid Metabolism, Inborn Errors; Biopsy; Cells, Cultured; Fibroblasts; Heterozygote; Homocysteine; Homozygote; Humans; Hydro-Lyases; Hydrogen-Ion Concentration; Kinetics; Pyridoxal Phosphate; Serine; Skin | 1973 |
Characterization of two complementary polypeptide chains obtained by proteolysis of rabbit muscle phosphorylase.
Topics: Alkylation; Amino Acids; Animals; Binding Sites; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Kinetics; Lysine; Macromolecular Substances; Molecular Weight; Muscles; Organophosphorus Compounds; Peptide Fragments; Phosphorus Radioisotopes; Phosphorylases; Protein Binding; Pyridoxal Phosphate; Rabbits; Serine; Sodium Dodecyl Sulfate; Solubility; Subtilisins; Trypsin | 1973 |
Purification and characterization of a B6-independent threonine dehydratase from Pseudomonas putida.
Topics: Amino Acids; Ammonium Sulfate; Binding Sites; Carbon Radioisotopes; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gas; Chromatography, Gel; Culture Media; Electrophoresis, Polyacrylamide Gel; Hydro-Lyases; Hydrogen-Ion Concentration; Isoleucine; Protamines; Pseudomonas; Pyridoxal Phosphate; Serine; Threonine; Tritium; Ultracentrifugation | 1974 |
Interactions between the subunits of the tryptophan synthetase of Escherichia coli. Optical properties of an intermediate bound to the alpha-2 beta-2 complex.
Topics: Acrylates; Amino Acids; Catalysis; Centrifugation, Density Gradient; Centrifugation, Zonal; Chemical Phenomena; Chemistry, Physical; Cysteine; Escherichia coli; Hydro-Lyases; Mercaptoethanol; Protein Binding; Pyridoxal Phosphate; Serine; Spectrophotometry | 1967 |
A new thiol-dependent transamination reaction catalyzed by the B protein of Escherichia coli tryptophan synthetase.
Topics: Amino Acids; Aspartate Aminotransferases; Bacterial Proteins; Carbon Isotopes; Chromatography, Paper; Dialysis; Electrophoresis; Escherichia coli; Hydro-Lyases; Keto Acids; Kinetics; Mercaptoethanol; Pyridoxal Phosphate; Pyruvates; Serine; Spectrophotometry; Sulfhydryl Compounds; Time Factors; Tryptophan | 1968 |
Fluorescence studies of substrate and subunit interactions of the beta-2 protein of Escherichia coli tryptophan synthetase.
Topics: Bacterial Proteins; Binding Sites; Chemical Phenomena; Chemistry; Escherichia coli; Fluorescence; Fluorometry; Hydrogen-Ion Concentration; Indoles; Ligases; Pyridoxal Phosphate; Serine; Spectrophotometry; Threonine; Tryptophan | 1968 |
Properties and catalytic activities of vitamin B6 N-oxide.
Topics: Amines; Aspartate Aminotransferases; Catalysis; Chelating Agents; Coenzymes; Escherichia coli; Hot Temperature; Hydro-Lyases; Ketoglutaric Acids; Kinetics; Magnetic Resonance Spectroscopy; Optical Rotatory Dispersion; Oxides; Phosphates; Pyridines; Pyridoxal Phosphate; Pyridoxine; Serine; Spectrum Analysis; Tryptophan | 1969 |
The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Topics: Amino Acids; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Thin Layer; Cysteine; Electrophoresis, Disc; Hydro-Lyases; Kinetics; Methods; Molecular Weight; Peptides; Pyridoxal Phosphate; Salmonella typhimurium; Serine; Spectrophotometry; Trypsin; Ultracentrifugation | 1969 |
Tryptophan synthase from Nicotiana tabacum.
Topics: Animals; Antigen-Antibody Reactions; Biological Evolution; Centrifugation, Density Gradient; Chemical Precipitation; Culture Techniques; Escherichia coli; Glycerophosphates; Hot Temperature; Hydro-Lyases; Hydrogen-Ion Concentration; Indoles; Kinetics; Nicotiana; Plants; Plants, Toxic; Pyridoxal Phosphate; Rabbits; Serine; Tritium; Tryptophan | 1968 |
Structure of the binding site of pyridoxal 5'-phosphate to Escherichia coli glutamate decarboxylase.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Amino Acids; Benzoates; Binding Sites; Boron Compounds; Carboxy-Lyases; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Escherichia coli; Fluorescence; Freeze Drying; Glutamates; Hydrogen-Ion Concentration; Methods; Peptides; Pyridoxal Phosphate; Serine; Spectrophotometry; Sulfhydryl Compounds; Sulfides; Sulfonic Acids; Trypsin; Ultraviolet Rays | 1970 |
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
Topics: Alanine; Amino Acids; Ammonia; Catechols; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Culture Media; Cysteine; Electrophoresis; Escherichia coli; Feedback; Kinetics; Lyases; Methods; Molecular Weight; Phenols; Protamines; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Stereoisomerism; Sulfates; Tyrosine; Ultracentrifugation | 1970 |
A steady-state kinetic investigation of the reaction mechanism of the tryptophan synthetase of Escherichia coli.
Topics: Binding Sites; Chromatography, Gel; Escherichia coli; Feedback; Fluorescence; Glyceraldehyde; Glycerides; Hydro-Lyases; Indoles; Kinetics; Models, Biological; Models, Chemical; Models, Structural; Phosphoric Acids; Pyridoxal Phosphate; Serine; Tryptophan | 1970 |
Tryptophan synthetase 2 subunit. Primary structure of the pyridoxyl peptide from the Escherichia coli enzyme.
Topics: Amino Acid Sequence; Amino Acids; Borohydrides; Carboxypeptidases; Chromatography, Ion Exchange; Dansyl Compounds; Electrophoresis, Paper; Escherichia coli; Formates; Glycerophosphates; Hydro-Lyases; Indoles; Lysine; Macromolecular Substances; Oxidation-Reduction; Peptides; Pyridoxal Phosphate; Serine; Tritium; Trypsin | 1971 |
Enzymatic formation of beta-cyanoalanine from cyanide.
Topics: Adenosine Triphosphate; Alanine; Chemical Phenomena; Chemistry; Chloromercuribenzoates; Cyanides; Cysteine; Edetic Acid; Hydroxylamines; Indicators and Reagents; Isoniazid; Magnesium; Mercury; Plants; Pyridoxal Phosphate; Semicarbazides; Serine | 1965 |
L-serine dehydratase (deaminase) of psychrophiles and mesophiles from polar and temperate habitats.
Topics: Adenine Nucleotides; Cell-Free System; Coenzymes; Cold Temperature; Escherichia coli; Glutathione; Hydro-Lyases; L-Serine Dehydratase; Phosphatidylcholines; Plants; Pseudomonas; Pseudomonas aeruginosa; Pyridoxal Phosphate; Pyruvates; Serine; Temperature | 1967 |
Properties and subunit structure of the B component of Pseudomonas putida tryptophan synthetase.
Topics: Alanine; Amino Acids; Borohydrides; Carboxypeptidases; Catalysis; Chemical Precipitation; Chromatography, Gel; Cross Reactions; Detergents; Drug Stability; Electrophoresis, Disc; Escherichia coli; Formates; Glycerophosphates; Hot Temperature; Hydro-Lyases; Immune Sera; Immunodiffusion; Indoles; Kinetics; Macromolecular Substances; Mercaptoethanol; Molecular Weight; Oxidation-Reduction; Pseudomonas; Pyridoxal Phosphate; Serine; Spectrophotometry; Sulfuric Acids; Tryptophan; Ultracentrifugation; Urea | 1971 |
Threonine deaminase (dehydratase) in Azotobacter chroococcum.
Topics: Adenosine Monophosphate; Ammonia; Arsenic; Aspartic Acid; Azotobacter; Butyrates; Chromatography; Cyanides; Edetic Acid; Enzyme Activation; Fluorides; Glutamates; Hydro-Lyases; Hydrogen-Ion Concentration; Keto Acids; Kinetics; Potassium; Pyridoxal Phosphate; Quinolines; Serine; Sulfites; Thiocarbamates; Threonine | 1971 |
Studies on biosynthetic conversion of cholesterol into pregnenolone. Side chain cleavage of a t-butyl analog of 20-hydroxycholesterol, (20R t-butyl-5-pregnene-3, 20-diol, a compound completely substituted at C-22).
Topics: Apoproteins; Benzoates; Borohydrides; Chemical Phenomena; Chemistry, Physical; Densitometry; Disulfides; Glycerophosphates; Hydro-Lyases; Indoles; Macromolecular Substances; Mathematics; Mercaptoethanol; Molecular Weight; Nitro Compounds; Oxidation-Reduction; Protein Binding; Protein Denaturation; Pyridoxal Phosphate; Serine; Spectrophotometry; Sulfhydryl Compounds; Tryptophan Synthase; Ultracentrifugation; Ultraviolet Rays | 1972 |
The synthesis of taurine from sulfate. 3. Further evidence for the enzymatic pathway in chick liver.
Topics: Adenine Nucleotides; Alanine; Animals; Carbon Isotopes; Carboxy-Lyases; Chickens; Chromatography, Ion Exchange; L-Serine Dehydratase; Liver; Pyridoxal Phosphate; Serine; Sulfates; Sulfonic Acids; Sulfurtransferases; Taurine | 1972 |
Influence of monovalent cations on the activity of L-serine (L-threonine) dehydratase from rat liver. The control of threonine-serine activity ratio.
Topics: Ammonium Chloride; Ammonium Sulfate; Animals; Apoproteins; Binding Sites; Chloromercuribenzoates; Drug Stability; Enzyme Induction; Hot Temperature; Hydro-Lyases; Kinetics; L-Serine Dehydratase; Liver; Male; Potassium Chloride; Protein Binding; Pyridoxal Phosphate; Rats; Serine; Threonine | 1972 |
Ferrous ion-dependent L-serine dehydratase from Clostridium acidiurici.
Topics: Ammonium Sulfate; Buffers; Catalysis; Cell-Free System; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Clostridium; Coenzymes; Culture Media; Dialysis; Dithiothreitol; Enzyme Activation; Fluorescence; Hydrogen-Ion Concentration; Iron; L-Serine Dehydratase; Molecular Weight; Pyridoxal Phosphate; Serine; Spectrophotometry; Stereoisomerism; Ultraviolet Rays | 1972 |
The isolation of serine transhydroxymethylase from bovine brain.
Topics: Ammonium Sulfate; Animals; Brain; Carbon Isotopes; Cattle; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Activation; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Pyridoxal Phosphate; Serine; Transferases | 1972 |
Threonine dehydratase from goat liver.
Topics: Ammonium Sulfate; Animals; Chloromercuribenzoates; Chromatography, DEAE-Cellulose; Cysteine; Goats; Hydro-Lyases; Hydrogen-Ion Concentration; Kinetics; Liver; Pyridoxal Phosphate; Serine; Threonine | 1972 |
A kinetic investigation of the interaction of serine transhydroxymethylase with glycine.
Topics: Animals; Glycine; Kinetics; Liver; Models, Chemical; Oscillometry; Pyridoxal Phosphate; Rabbits; Serine; Spectrophotometry; Temperature; Tetrahydrofolates; Transferases; Ultraviolet Rays | 1972 |
Serum aminotransferase activities and plasma free amino acid concentration as criteria for pyridoxine nutritional status of chicks.
Topics: Alanine Transaminase; Amino Acids; Aminobutyrates; Ammonia; Animal Nutritional Physiological Phenomena; Animals; Asparagine; Aspartate Aminotransferases; Body Weight; Chickens; Cysteine; Diet; Feeding Behavior; Glutamine; Glycine; Male; Ornithine; Pyridoxal Phosphate; Pyridoxine; Serine; Taurine; Vitamin B 6 Deficiency | 1972 |
On the mechanism of the nullification of CNS effects of L-DOPA by pyridoxine in Parkinsonian patients.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Basal Ganglia; Benzyl Compounds; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Hydrazines; Male; Parkinson Disease; Pyridoxal Phosphate; Pyridoxine; Rats; Serine | 1972 |
Cystathionine -synthase. Studies of hydrogen exchange reactions.
Topics: Alanine; Aminobutyrates; Catalysis; Chemical Phenomena; Chemistry; Cystathionine; Cysteine; Deuterium; Homoserine; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Salmonella; Serine; Succinates; Tritium | 1972 |
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine -synthase.
Topics: Acetates; Alanine; Amino Acids; Animals; Catalysis; Chickens; Chlorine; Chromatography, Gel; Chromatography, Paper; Cycloserine; Cysteamine; Cysteine; Electrophoresis, Paper; Glycolates; Homocysteine; Hydro-Lyases; Hydroxylamines; Isoelectric Focusing; Kinetics; L-Serine Dehydratase; Liver; Mercaptoethanol; Nitriles; Penicillamine; Propionates; Pyridoxal Phosphate; Rats; Serine; Species Specificity; Sulfhydryl Compounds; Sulfides; Sulfuric Acids; Thioglycolates | 1971 |
Tryptophan synthetase 2 subunit. Primary structure of the pyridoxyl peptide from the Pseudomonas putida enzyme.
Topics: Amino Acid Sequence; Amino Acids; Borohydrides; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Dansyl Compounds; Formates; Glycerophosphates; Hydro-Lyases; Indoles; Oxidation-Reduction; Peptides; Pseudomonas; Pyridoxal Phosphate; Serine; Thermolysin; Tritium; Trypsin | 1971 |
Association of the alpha and beta-2 subunits of the tryptophan synthetase of Escherichia coli.
Topics: Bacterial Proteins; Chromatography, Gel; Escherichia coli; Hydro-Lyases; In Vitro Techniques; Indoles; Molecular Biology; Mutation; Pyridoxal Phosphate; Serine; Sodium Chloride; Tryptophan; Ultracentrifugation | 1966 |
Studies on amino acid racemases. I. Partial purification and properties of the alanine racemase from Lactobacillus fermenti.
Topics: Acetates; Alanine; Aminobutyrates; Aspartic Acid; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Computers; Cysteine; Drug Stability; Glutamates; Glutathione; Hydrogen-Ion Concentration; Isomerases; Kinetics; Lactobacillus; Mercaptoethanol; Methods; Models, Biological; Models, Chemical; Pyridoxal Phosphate; Serine; Stereoisomerism; Temperature | 1969 |
The mechanism of action of serine transhydroxymethylase.
Topics: Folic Acid; Formaldehyde; Glycine; Models, Chemical; Pyridoxal Phosphate; Serine; Transferases; Tritium | 1970 |
Pyridoxine and pyridoxal analogs. 13. A nuclear magnetic resonance study of the condensation of polyfunctional amino acids with pyridoxal.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Cycloserine; Histidine; Homocysteine; Homocystine; Imidazoles; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Serine; Threonine | 1970 |
Glyoxylate aminotansferases from oat leaves.
Topics: Edible Grain; Enzyme Activation; Glyoxylates; Kinetics; Metals; Plants; Pyridoxal Phosphate; Serine; Sulfhydryl Compounds; Transaminases | 1970 |
Crystalline threonine aldolase from Candida humicola.
Topics: Acetaldehyde; Aldehyde-Lyases; Candida; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Electrophoresis, Disc; Glycine; Hydrogen-Ion Concentration; Methods; Molecular Weight; Pyridoxal Phosphate; Serine; Spectrum Analysis; Threonine; Ultracentrifugation; Ultraviolet Rays | 1970 |
A modified assay for cystathionine synthase.
Topics: Adult; Aged; Amino Acids; Animals; Carbon Isotopes; Chromatography, Paper; Homocysteine; Humans; Hydro-Lyases; L-Serine Dehydratase; Liver; Male; Methods; Pyridoxal Phosphate; Pyruvates; Rats; Serine; Taurine | 1970 |
Homocystinuria due to cystathionine synthase deficiency: the effect of pyridoxine.
Topics: Adult; Aldehydes; Autoanalysis; Carbon Isotopes; Chromatography; Cysteine; Diet; Diet Therapy; Enzyme Activation; Female; Fibroblasts; Homocystine; Homocystinuria; Humans; Hydro-Lyases; Keto Acids; L-Serine Dehydratase; Liver; Male; Methionine; Pyridoxal Phosphate; Pyridoxine; Serine; Sulfates; Trypsin | 1970 |
The alpha beta-elimination of L-serylglycine O-sulphate and related dipeptides.
Topics: Catalysis; Copper; Dipeptides; Glycine; Pyridoxal Phosphate; Serine; Sulfates | 1970 |
Purification and characterization of L-serine transacetylase and O-acetyl-L-serine sulfhydrylase from kidney bean seedlings (Phaseolus vulgaris).
Topics: Acetates; Acyltransferases; Carbon Isotopes; Chemical Precipitation; Chloromercuribenzoates; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cysteine; Ethylmaleimide; Hydrogen-Ion Concentration; Lyases; Plants; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Serine; Sulfates; Sulfhydryl Reagents | 1971 |
Serine transhydroxymethylase. Affinity of the active site for substrates, substrate analogues, and anions.
Topics: Alanine; Aldehydes; Aminoisobutyric Acids; Animals; Benzoates; Binding Sites; Chlorides; Cysteamine; Cysteine; Electrophoresis; Folic Acid; Glycine; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Models, Biological; Organophosphonates; Phosphates; Potassium; Propionates; Pyridoxal Phosphate; Rabbits; Serine; Spectrophotometry; Stereoisomerism; Sulfates; Sulfhydryl Compounds; Sulfonic Acids; Thermodynamics; Threonine; Transferases; Ultracentrifugation | 1971 |
Transsulfuration in higher plants. Partial purification and properties of beta-cystathionase of spinach.
Topics: Alanine; Amino Acids; Benzoates; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Cysteine; Drug Stability; Edible Grain; Ethylmaleimide; Homocysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; Models, Structural; Plants; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Species Specificity; Spectrophotometry; Stereoisomerism; Sulfates; Sulfides; Sulfur; Triticum | 1971 |
Cystathionine synthase from rat liver: partial purification and properties.
Topics: Amino Acids; Animals; Benzoates; Boron Compounds; Calcium Phosphates; Carbon Isotopes; Chromatography, Gel; Cysteine; Drug Stability; Electrophoresis; Enzyme Activation; Homocysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; L-Serine Dehydratase; Liver; Mercury; Oxidation-Reduction; Protamines; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Rats; Serine; Spectrophotometry; Sulfates; Sulfides; Temperature | 1971 |
The reversible inactivation of L-threonine hydratase of sheep liver by L-serine.
Topics: Animals; Binding Sites; Coenzymes; Dialysis; Hydro-Lyases; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoglutaric Acids; Kinetics; Liver; Oxazoles; Phosphates; Potassium; Potassium Chloride; Pyridoxal Phosphate; Pyruvates; Quaternary Ammonium Compounds; Serine; Sheep; Threonine; Time Factors | 1968 |
Cysteine biosynthesis in Pasteurella multocida. Cysteine synthase, purification and properties.
Topics: Adsorption; Aspartate Aminotransferases; Calcium Phosphates; Cell-Free System; Cellulose; Centrifugation, Zonal; Chemical Precipitation; Chromatography, Ion Exchange; Colorimetry; Cysteine; Hydro-Lyases; Hydrogen-Ion Concentration; Ions; Kinetics; Oxidoreductases; Pasteurella; Pyridoxal Phosphate; Serine; Sulfides; Sulfur Isotopes | 1968 |
Enzymes of the clostridial purine fermentation. Serine hydroxymethyltransferase.
Topics: Cellulose; Chemical Precipitation; Chromatography, Ion Exchange; Clostridium; Freeze Drying; Hydrogen-Ion Concentration; Kinetics; Purines; Pyridoxal Phosphate; Serine; Spectrophotometry; Transferases | 1968 |
Proton retention in the gamma-elimination reaction catalysed by cystathionine gamma-synthase.
Topics: Cysteine; Deuterium; Dinitrophenols; Hydrazines; Hydro-Lyases; Hydrogen; Keto Acids; Magnetic Resonance Spectroscopy; Protons; Pyridoxal Phosphate; Serine; Succinates; Tritium; Water | 1968 |
Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase.
Topics: Amino Acids; Animals; Chemistry Techniques, Analytical; Hydro-Lyases; Hydroxylamines; Liver; Male; Methods; Pyridoxal Phosphate; Rats; Serine | 1968 |
The pyridoxal- and pyridoxal 5'-phosphate-catalysed non-enzymic degradations of l-serine o-sulphate and related compounds.
Topics: Aluminum; Ammonia; Catalysis; Copper; Gallium; Hydrogen-Ion Concentration; Keto Acids; Methanol; Picolines; Pyridoxal Phosphate; Serine; Sulfates; Threonine | 1968 |
Serine transhydroxymethylase in developing mouse brain.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Carbon Isotopes; Folic Acid; Formaldehyde; Glycine; Mice; Pyridoxal Phosphate; Serine; Tissue Extracts; Transferases | 1968 |
Reversibility of the thyroxine effect on rat liver glutamic-pyruvic transaminase and serine dehydrase by dietary supplementation of vitamin B6.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diet; Hydro-Lyases; Liver; Pyridoxal Phosphate; Pyridoxine; Rats; Serine; Thyroxine | 1969 |
A rat liver system that catalyses a pyridoxal phosphate-independent alpha beta-eliminto.
Topics: Alanine Transaminase; Animals; Enzymes; Isoniazid; Liver; Protein Binding; Pyridoxal Phosphate; Rats; Serine; Sulfates; Sulfur Isotopes; Tritium; Vitamin B 6 Deficiency | 1969 |
D-serine dehydratase of chicken kidney.
Topics: Animals; Dialysis; Hydro-Lyases; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kinetics; Magnesium; Manganese; Poultry; Pyridoxal Phosphate; Serine; Sulfhydryl Compounds; Temperature | 1965 |
Purification and properties of serine hydroxymethylase from human leukaemic leukocytes.
Topics: Humans; Leukemia; Leukocytes; Mixed Function Oxygenases; Pyridoxal Phosphate; Serine | 1965 |
[Studies on serine dehydratase reaction in yeast].
Topics: Chromatography, Gel; Chromatography, Ion Exchange; Enzymes; Hydro-Lyases; Kinetics; Leucine; Pyridoxal Phosphate; Saccharomyces; Serine; Threonine | 1965 |
[Synthesis of cysteine in skin homogenates].
Topics: Animals; Autoradiography; Culture Techniques; Cysteine; Liver; Pyridoxal Phosphate; Rabbits; Serine; Sheep; Skin; Sulfur Isotopes | 1966 |
Synthesis and properties of some N-pyridoxyl-L-amino acids and N-(5-phosphopyridoxyl)-L-amino acids.
Topics: Alanine; Aldehydes; Arginine; Aspartic Acid; Chemistry, Organic; Chromatography, Paper; Glutamates; Organic Chemistry Phenomena; Pyridines; Pyridoxal Phosphate; Pyrrolidinones; Serine; Tryptophan; Tyrosine | 1967 |
The mechanism of the reaction of beta-hydroxyaspartate with L-aspartate beta-decarboxylase. A new type of pyridoxal 5'-phosphate-enzyme inhibition.
Topics: Alcaligenes; Aldehydes; Amino Acids; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Chromatography, Gel; Cysteine; Enzymes; Hydrazones; Phenylhydrazines; Pyridoxal Phosphate; Serine; Spectrophotometry; Sulfinic Acids | 1967 |
Glycine synthesis by extracts of acetone powder of rat-liver mitochondria.
Topics: Acetone; Animals; Carbon Isotopes; Dialysis; Folic Acid; Glycine; Liver; Mitochondria; Pyridoxal Phosphate; Rats; Serine; Transferases | 1967 |
Purification and properties of an asparagine aminotransferase from Pisum sativum leaves.
Topics: Asparagine; Fabaceae; Glyoxylates; Hydrogen-Ion Concentration; Plants, Medicinal; Pyridoxal Phosphate; Serine; Substrate Specificity; Transaminases | 1983 |
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes.
Topics: Acyl Coenzyme A; Acyltransferases; Animals; Female; Microsomes, Liver; Pyridoxal Phosphate; Rats; Rats, Inbred BUF; Serine; Serine C-Palmitoyltransferase; Sphingolipids; Sphingosine; Subcellular Fractions; Substrate Specificity | 1984 |
Structural and functional alterations of E. coli tryptophan synthase upon binding of pyridoxal 5'-phosphate.
Topics: Binding Sites; Escherichia coli; Indoles; Kinetics; Pyridoxal Phosphate; Serine; Tryptophan; Tryptophan Synthase | 1984 |
Kinetic and thermodynamic parameters for Schiff base formation of vitamin B6 derivatives with amino acids.
Topics: Amino Acids; Aminocaproic Acid; Kinetics; Pyridoxal; Pyridoxal Phosphate; Pyridoxine; Schiff Bases; Serine; Thermodynamics | 1984 |
Inactivation of the Pseudomonas striata broad specificity amino acid racemase by D and L isomers of beta-substituted alanines: kinetics, stoichiometry, active site peptide, and mechanistic studies.
Topics: Alanine; Amino Acid Isomerases; Amino Acids; beta-Alanine; Binding Sites; Borates; Isomerism; Kinetics; Molecular Weight; NAD; Pseudomonas; Pyridoxal Phosphate; Serine; Trypsin | 1984 |
Kinetics of cooperative ligand binding to the apo beta 2 subunit of tryptophan synthase and its modulation by the alp ha subunit.
Topics: Apoenzymes; Binding Sites; Escherichia coli; Kinetics; Macromolecular Substances; Mathematics; Protein Binding; Pyridoxal Phosphate; Pyridoxine; Serine; Trypsin; Tryptophan Synthase | 1980 |
Spectrophotometric measurement of hydroxylamine and its O-alkyl derivatives.
Topics: Aminobutyrates; Aminooxyacetic Acid; Arginase; Ethers; Hydrolysis; Hydroxylamines; Kinetics; Pyridoxal Phosphate; Serine; Spectrophotometry; Spectrophotometry, Ultraviolet | 1981 |
Studies on the association of the alpha and beta 2 subunits of the tryptophan synthase of Bacillus subtilis.
Topics: Ammonium Chloride; Bacillus subtilis; Chemical Phenomena; Chemistry; Glycerol; Hydrogen-Ion Concentration; Potassium; Pyridoxal Phosphate; Serine; Sodium; Temperature; Tryptophan Synthase | 1981 |
Spectroscopic and kinetic evidence for a cyclic geminal diamine intermediate in the reaction of O-aminoserine with pyridoxal 5'-phosphate in alkali.
Topics: Chemical Phenomena; Chemistry; Diamines; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Serine; Spectrophotometry, Ultraviolet | 1981 |
A novel reaction of the coenzyme of glutamate decarboxylase with L-serine O-sulfate.
Topics: Carboxy-Lyases; Chemical Phenomena; Chemistry; Escherichia coli; Glutamate Decarboxylase; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Serine; Spectrophotometry | 1982 |
Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Topics: Acetates; Binding Sites; Catalysis; Cysteine Synthase; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lysine; Models, Chemical; Nitrobenzoates; Pyridoxal Phosphate; Salmonella typhimurium; Schiff Bases; Serine; Spectrophotometry; Sulfhydryl Compounds; Thermodynamics; Titrimetry | 1995 |
Ligand-mediated changes in the tryptophan synthase indole tunnel probed by nile red fluorescence with wild type, mutant, and chemically modified enzymes.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Codon; Computer Graphics; Computer Simulation; Cysteine; Escherichia coli; Fluorescent Dyes; Indoles; Iodides; Kinetics; Ligands; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oxazines; Phenylalanine; Point Mutation; Protein Conformation; Pyridoxal Phosphate; Recombinant Proteins; Salmonella typhimurium; Serine; Spectrometry, Fluorescence; Tryptophan; Tryptophan Synthase | 1995 |
Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Escherichia coli; Heme; Hemeproteins; Homocysteine; Humans; Kinetics; Liver; Pyridoxal Phosphate; Rats; Recombinant Proteins; Serine; Spectrophotometry; Sulfur | 1994 |
Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Topics: Acetates; Binding Sites; Circular Dichroism; Cysteine; Cysteine Synthase; Hydrogen-Ion Concentration; Protein Conformation; Pyridoxal Phosphate; Regression Analysis; Salmonella typhimurium; Schiff Bases; Serine; Spectrometry, Fluorescence; Tryptophan | 1994 |
A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.
Topics: Alcohol Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Carbohydrate Dehydrogenases; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Glutarates; Glyceric Acids; Glycine; Humans; Ketoglutaric Acids; Kinetics; Models, Chemical; Oxidation-Reduction; Phosphoglycerate Dehydrogenase; Pyridoxal Phosphate; Pyruvates; Serine | 1996 |
Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.
Topics: Allosteric Regulation; Hydrogen-Ion Concentration; Ligands; Protein Conformation; Protons; Pyridoxal Phosphate; Salmonella typhimurium; Schiff Bases; Serine; Temperature; Tryptophan Synthase | 1996 |
A novel phenylserine dehydratase from Pseudomonas pickettii PS22: purification, characterization, and sequence of its phosphopyridoxyl peptide.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Enzyme Stability; Hydro-Lyases; Isoelectric Point; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Pseudomonas; Pyridoxal Phosphate; Sequence Analysis; Serine; Substrate Specificity; Trypsin | 1996 |
Mutation of cysteine 111 in Dopa decarboxylase leads to active site perturbation.
Topics: 5-Hydroxytryptophan; Alanine; Animals; Base Sequence; Binding Sites; Circular Dichroism; Cysteine; Dopa Decarboxylase; Hydrogen-Ion Concentration; Kidney; Kinetics; Levodopa; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry; Structure-Activity Relationship; Swine | 1997 |
Substrate inhibition of D-amino acid transaminase and protection by salts and by reduced nicotinamide adenine dinucleotide: isolation and initial characterization of a pyridoxo intermediate related to inactivation.
Topics: Alanine; Catalysis; Chromatography, High Pressure Liquid; D-Alanine Transaminase; Enzyme Inhibitors; NAD; Pyridoxal Phosphate; Pyridoxamine; Pyruvic Acid; Salts; Serine; Transaminases | 1998 |
Mutation of an active site residue of tryptophan synthase (beta-serine 377) alters cofactor chemistry.
Topics: Aspartic Acid; Bacterial Proteins; Binding Sites; Glutamates; Hydrogen-Ion Concentration; Macromolecular Substances; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Schiff Bases; Serine; Spectrum Analysis; Structure-Activity Relationship; Tryptophan; Tryptophan Synthase | 1998 |
Occurrence of pyridoxal 5'-phosphate-dependent serine racemase in silkworm, Bombyx mori.
Topics: Animals; Bombyx; Enzyme Inhibitors; Hydrogen-Ion Concentration; Hydroxylamine; Kinetics; Mammals; Pupa; Pyridoxal Phosphate; Racemases and Epimerases; Serine; Stereoisomerism; Substrate Specificity | 1998 |
Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase.
Topics: Animals; Asparagine; Aspartic Acid; Cloning, Molecular; Cytosol; Escherichia coli; Glycine Hydroxymethyltransferase; Isoelectric Focusing; Isomerism; Kinetics; Pyridoxal Phosphate; Rabbits; Recombinant Proteins; Serine; Spectrophotometry; Tetrahydrofolates | 1998 |
Tryptophan synthase mutations that alter cofactor chemistry lead to mechanism-based inactivation.
Topics: Alanine; Aspartic Acid; Bacterial Proteins; Catalysis; Circular Dichroism; Enzyme Activation; Multienzyme Complexes; Mutagenesis, Site-Directed; Peptide Fragments; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Substrate Specificity; Tryptophan Synthase | 1998 |
Purification of serine racemase: biosynthesis of the neuromodulator D-serine.
Topics: Amino Acid Isomerases; Aminooxyacetic Acid; Animals; Cerebral Cortex; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Neuroglia; Pyridoxal Phosphate; Racemases and Epimerases; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Spectrophotometry; Substrate Specificity; Temperature | 1999 |
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites.
Topics: Binding Sites; Carbon Monoxide; Catalysis; Cyanides; Cystathionine beta-Synthase; Enzyme Activation; Heme; Humans; Ligands; Pyridoxal Phosphate; Recombinant Proteins; Serine; Spectrometry, Fluorescence | 1999 |
Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase.
Topics: Amino Acid Sequence; Binding Sites; Cystathionine beta-Synthase; Hemeproteins; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Pyridoxal Phosphate; Recombinant Proteins; S-Adenosylmethionine; Sequence Homology, Amino Acid; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1999 |
Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands.
Topics: Alanine; Allosteric Regulation; Catalytic Domain; Deuterium; Glycine; Hydrogen-Ion Concentration; Indoles; Ligands; Models, Chemical; Oxindoles; Pyridoxal Phosphate; Salmonella typhimurium; Serine; Tryptophan Synthase | 1999 |
Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration.
Topics: Animals; Chromatography, High Pressure Liquid; Cystathionine beta-Synthase; Diet; Glycine Hydroxymethyltransferase; Homocysteine; Liver; Male; Methylation; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Serine; Sulfurtransferases; Vitamin B 6 Deficiency | 2000 |
The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase.
Topics: Alanine; Amino Acid Substitution; Animals; Apoenzymes; Binding Sites; Calorimetry, Differential Scanning; Catalysis; Cytosol; Formaldehyde; Glutamic Acid; Glycine Hydroxymethyltransferase; Humans; Kinetics; Liver; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Rabbits; Recombinant Fusion Proteins; Serine; Sheep; Structure-Activity Relationship; Tetrahydrofolates; Tyrosine | 2000 |
Functional properties of the active core of human cystathionine beta-synthase crystals.
Topics: Binding Sites; Carbon Monoxide; Cystathionine beta-Synthase; Heme; Homocysteine; Humans; Microspectrophotometry; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Serine; Structure-Activity Relationship | 2001 |
Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.
Topics: Amino Acid Sequence; Binding Sites; Cystathionine beta-Synthase; Dithiothreitol; Electron Spin Resonance Spectroscopy; Heme; Humans; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Oxygen; Pyridoxal Phosphate; Serine; Yeasts | 2001 |
Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme.
Topics: Amino Acid Sequence; Arabidopsis; Carboxy-Lyases; Cloning, Molecular; DNA, Complementary; Ethanolamine; Genetic Complementation Test; Molecular Sequence Data; Plant Leaves; Pyridoxal Phosphate; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Serine | 2001 |
Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine.
Topics: Circular Dichroism; Cystathionine; Cystathionine beta-Synthase; Homocysteine; Kinetics; Magnetic Resonance Spectroscopy; Pyridoxal Phosphate; Saccharomyces cerevisiae; Serine; Spectrophotometry; Substrate Specificity; Threonine | 2002 |
Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.
Topics: Bacterial Proteins; Binding Sites; Cysteine; Cysteine Synthase; Genes, Bacterial; Isoenzymes; Molecular Structure; Pyridoxal Phosphate; Schiff Bases; Serine; Spectrum Analysis; Transaminases | 2002 |
On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase.
Topics: Allosteric Regulation; Catalysis; Conserved Sequence; Crystallography, X-Ray; Glycerophosphates; Hydrogen Bonding; Indoles; Kinetics; Ligands; Models, Chemical; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridoxal Phosphate; Serine; Stereoisomerism; Structure-Activity Relationship; Threonine; Tryptophan Synthase; Valine | 2002 |
Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Cysteine Synthase; Deuterium; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Pyridines; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substrate Specificity | 2003 |
Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation.
Topics: Alanine Racemase; Amino Acid Substitution; Benzaldehydes; Binding Sites; Fructose-Bisphosphate Aldolase; Glycine; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Serine | 2003 |
[Role of pyridoxal phosphate in anaerobic deamination of homoserine and serine].
Topics: Biochemical Phenomena; Coenzymes; Deamination; Homoserine; Pyridoxal Phosphate; Serine; Streptococcus | 1952 |
Participation of pyridoxal phosphate in the enzymic synthesis of serine.
Topics: Biochemical Phenomena; Coenzymes; Pyridoxal Phosphate; Serine | 1954 |
The interconversion of serine and glycine: participation of pyridoxal phosphate.
Topics: Coenzymes; Fabaceae; Glycine; Pyridoxal Phosphate; Serine | 1955 |
SUCCINIC ESTER AND AMIDE OF HOMOSERINE: SOME SPONTANEOUS AND ENZYMATIC REACTIONS.
Topics: Amides; Amino Acids; Cysteine; Escherichia coli; Homoserine; Methionine; Pyridoxal Phosphate; Research; Salmonella; Serine; Succinates | 1964 |
[NON-ENZYMIC SYNTHESIS OF CYSTEIC ACID FROM SOME BETA-SUBSTITUTED AMINO ACIDS, PYRUVATE, SULPHITE, AND COPPER IONS].
Topics: Amino Acid Substitution; Amino Acids; Catalysis; Chelating Agents; Chemical Phenomena; Chemistry; Copper; Cysteic Acid; Cysteine; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Research; Serine; Sulfites; Sulfur | 1963 |
A STUDY OF THE PURIFICATION AND PROPERTIES OF TRYPTOPHAN SYNTHETASE OF BENGAL GRAM (CICER ARIETINUM).
Topics: Chemistry Techniques, Analytical; Cicer; Enzyme Inhibitors; Indoles; Isoniazid; Ligases; Penicillamine; Plants; Propionates; Pyridoxal Phosphate; Research; Serine; Tryptophan; Tryptophan Synthase | 1964 |
ORGAN AND INTRACELLULAR LOCATION OF THE METHIONINE METHYL GROUP SYNTHESIZING SYSTEM OF THE RAT.
Topics: Adenosine Triphosphate; Brain; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Folic Acid; Glucose; Homocysteine; Kidney; Leuconostoc; Liver; Magnesium; Methionine; Muscles; NAD; Pectoralis Muscles; Proteins; Pyridoxal Phosphate; Rats; Research; Serine; Spectrophotometry | 1964 |
CATALYTIC PROPERTIES OF TRYPTOPHANASE, A MULTIFUNCTIONAL PYRIDOXAL PHOSPHATE ENZYME.
Topics: Aminohydrolases; Ammonia; Animals; Catalysis; Cattle; Cysteine; Electrophoresis; Escherichia coli; Indoles; Leuconostoc; Manometry; Multifunctional Enzymes; Mutation; Potassium; Pyridoxal Phosphate; Pyruvates; Research; Serine; Serum Albumin; Serum Albumin, Bovine; Tryptophan | 1964 |
SERINE DEAMINATION BY THE B PROTEIN OF ESCHERICHIA COLI TRYPTOPHAN SYNTHETASE.
Topics: Bacterial Proteins; Chromatography; Deamination; Electrophoresis; Enzyme Inhibitors; Escherichia coli; Glycerophosphates; Hydro-Lyases; Indoles; Ligases; Membrane Glycoproteins; Oxidoreductases; Pyridoxal Phosphate; Research; Serine; Spectrophotometry; Threonine; Tryptophan; Tryptophan Synthase | 1964 |
RESPONSE OF 1-ASPARTIC-4-CARBOXYLASE TO SELECTED INHIBITORS.
Topics: Alanine; Aspartic Acid; Carbon Dioxide; Carboxy-Lyases; Enzyme Inhibitors; Flavobacterium; Keto Acids; Ketoglutaric Acids; Mitomycin; Mitomycins; Penicillins; Proteins; Pyridoxal Phosphate; Pyruvates; Research; Serine; Vancomycin | 1964 |
CYSTATHIONINE CLEAVAGE ENZYMES OF NEUROSPORA.
Topics: Amino Acid Oxidoreductases; Amino Acids; Butyrates; Cystathionine; Cysteine; Homocysteine; Iodoacetates; L-Lactate Dehydrogenase; Maleates; Neurospora; Pyridoxal Phosphate; Pyruvates; Research; Serine; Sulfhydryl Compounds | 1964 |
PURIFICATION AND PROPERTIES OF THE CYSTATHIONINE GAMMA-CLEAVAGE ENZYME OF NEUROSPORA.
Topics: Amino Acid Oxidoreductases; Amino Acids; Butyrates; Cystathionine; Cysteine; Cystine; Enzyme Inhibitors; Ethers; Gamma Rays; Neurospora; Pyridoxal Phosphate; Research; Serine; Sulfides | 1964 |
[ENZYMATIC BETA SUBSTITUTION OF PHOSPHOSERINE AND CYSTEINE BY SULFITE. SOME REMARKS ON THE MECHANISM OF BETA SUBSTITUTION IN THE PRESENCE OF PYRIDOXAL PHOSPHATE ENZYMES].
Topics: Cysteine; Extraembryonic Membranes; Hydro-Lyases; Lyases; Phosphates; Phosphoserine; Pyridoxal Phosphate; Serine; Sulfites; Sulfonic Acids; Sulfur Isotopes; Vitelline Membrane | 1964 |
RELATIONSHIP OF A BETA-ALANINE-PYRUVIC AMINOTRANSFERASE TO REVERSAL OF D-SERINE INHIBITION OF GROWTH.
Topics: Alanine; Alanine Transaminase; Aspartic Acid; beta-Alanine; Cycloserine; Flavobacterium; Ketoglutaric Acids; Mitomycin; Mitomycins; Pantothenic Acid; Penicillins; Pharmacology; Pyridoxal Phosphate; Pyruvates; Research; Serine; Transaminases; Vancomycin | 1964 |
EFFECT OF PYRIDOXINE DEFICIENCY ON NUCLEIC ACID METABOLISM IN THE RAT.
Topics: Adenine; DNA; Formates; Liver; Metabolism; Methionine; Nucleic Acids; Nucleosides; Pyridoxal Phosphate; Rats; Research; RNA; Serine; Spleen; Thymidine; Transferases; Vitamin B 6 Deficiency | 1965 |
Crystal structure of serine dehydratase from rat liver.
Topics: Animals; Apoenzymes; Binding Sites; Catalysis; Computer Simulation; Crystallization; Crystallography, X-Ray; L-Serine Dehydratase; Light; Liver; Models, Molecular; Molecular Weight; Pyridoxal Phosphate; Rats; Scattering, Radiation; Serine; Substrate Specificity | 2003 |
Pyridoxal phosphate as a cofactor for serine and threonine deaminase of neurospora.
Topics: Amidohydrolases; Coenzymes; Fungi; Neurospora; Organic Chemicals; Pyridoxal Phosphate; Serine; Threonine Dehydratase | 1952 |
Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.
Topics: Adult; Carbon Isotopes; Deuterium; Female; Glycine; Homocysteine; Humans; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pyridoxal Phosphate; Serine; Vitamin B 6 | 2005 |
Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Brain Injuries; Calcium Channels; Cell Survival; Cells, Cultured; Cerebral Cortex; Extracellular Fluid; Gliosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Serine; Signal Transduction; Stress, Mechanical | 2005 |
Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase.
Topics: Bacterial Proteins; Hydrostatic Pressure; Imines; Kinetics; Protein Conformation; Pyridoxal Phosphate; Salmonella typhimurium; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tryptophan; Tryptophan Synthase | 2005 |
Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana.
Topics: Amino Acid Sequence; Arabidopsis; Asparagine; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Cysteine Synthase; Cytosol; Databases, Protein; Glutamine; Kinetics; Ligands; Methionine; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plant Proteins; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Serine; Serine O-Acetyltransferase; Threonine | 2005 |
Molecular and biochemical characterization of a serine racemase from Arabidopsis thaliana.
Topics: Alanine; Arabidopsis; Arginine; Catalysis; Cations, Divalent; Dimerization; Escherichia coli; Glutamine; Hydro-Lyases; Hydrogen-Ion Concentration; In Situ Hybridization, Fluorescence; Metals; Molecular Sequence Data; Pyridoxal Phosphate; Racemases and Epimerases; Sequence Homology, Amino Acid; Serine; Stereoisomerism; Substrate Specificity | 2006 |
Stereoselectivity and expanded substrate scope of an engineered PLP-dependent aldolase.
Topics: Aldehyde-Lyases; Models, Molecular; Molecular Structure; Protein Engineering; Pyridoxal Phosphate; Serine; Substrate Specificity | 2006 |
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Topics: Amino Acid Substitution; Catalysis; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Humans; Hydrogen Bonding; Isoenzymes; Kinetics; L-Serine Dehydratase; Lung Neoplasms; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Pyridoxal Phosphate; Recombinant Proteins; Serine; Static Electricity | 2008 |
Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.
Topics: Crystallography, X-Ray; Cystathionine gamma-Lyase; Genetic Variation; Humans; Isoleucine; Kinetics; Models, Molecular; Molecular Conformation; Mutation; Polymorphism, Single Nucleotide; Pyridoxal Phosphate; Recombinant Proteins; Serine; Spectrophotometry; Templates, Genetic | 2008 |
D-amino acids in the brain: pyridoxal phosphate-dependent amino acid racemases and the physiology of D-serine.
Topics: Amino Acids; Animals; Brain; Isomerism; Pyridoxal Phosphate; Racemases and Epimerases; Rats; Serine | 2008 |
Inactive S298R disassembles the dodecameric L-aspartate 4-decarboxylase into dimers.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Bacterial Proteins; Binding Sites; Carboxy-Lyases; Computer Simulation; Dimerization; Escherichia coli; Models, Chemical; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Pseudomonas; Pyridoxal Phosphate; Serine | 2008 |
Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Geobacillus stearothermophilus; Glycine; Glycine Hydroxymethyltransferase; Models, Molecular; Protein Binding; Pyridoxal Phosphate; Serine; Stereoisomerism; Tetrahydrofolates; Threonine; Tyrosine | 2008 |
Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase.
Topics: Animals; Chromatography, Affinity; Cloning, Molecular; Coenzymes; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Gene Expression; Glycine Hydroxymethyltransferase; Plasmodium falciparum; Protein Binding; Pyridoxal Phosphate; Recombinant Fusion Proteins; RNA, Messenger; Serine; Substrate Specificity; Tetrahydrofolates | 2009 |
Dual roles of a conserved pair, Arg23 and Ser20, in recognition of multiple substrates in alpha-aminoadipate aminotransferase from Thermus thermophilus.
Topics: 2-Aminoadipate Transaminase; 2-Aminoadipic Acid; Arginine; Conserved Sequence; Crystallography, X-Ray; Glutamates; Protein Structure, Secondary; Pyridines; Pyridoxal Phosphate; Serine; Substrate Specificity; Thermus thermophilus | 2009 |
Assay of alanine:glyoxylate aminotransferase in human liver by its serine: glyoxylate aminotransferase activity.
Topics: Alanine; Animals; Biological Assay; Humans; Liver; Pyridoxal Phosphate; Serine; Tissue Extracts; Transaminases | 2009 |
K30, H150, and H168 are essential residues for coordinating pyridoxal 5'-phosphate of O-acetylserine sulfhydrylase from Acidithiobacillus ferrooxidans.
Topics: Acidithiobacillus; Amino Acid Sequence; Catalytic Domain; Cloning, Molecular; Coenzymes; Conserved Sequence; Cysteine Synthase; Escherichia coli; Molecular Sequence Data; Protein Binding; Pyridoxal Phosphate; Recombinant Proteins; Schiff Bases; Serine | 2010 |
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
Topics: Animals; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Malonates; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Pyridoxal Phosphate; Racemases and Epimerases; Rats; Receptors, N-Methyl-D-Aspartate; Serine | 2010 |
Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Nucleotides; Phosphorylation; Platelet Aggregation Inhibitors; Protein Kinase C; Pyridoxal Phosphate; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Receptors, Purinergic P2Y2; Serine; Transfection | 2010 |
Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis.
Topics: Carbohydrate Dehydrogenases; Epistasis, Genetic; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genes, Bacterial; Glucose; Metabolic Networks and Pathways; Microbiological Techniques; Models, Biological; Organisms, Genetically Modified; Oxidoreductases; Pyridoxal Phosphate; Serine | 2010 |
A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the Aplysia californica central nervous system.
Topics: Amino Acid Isomerases; Animals; Aplysia; Aspartic Acid; Nervous System; Pyridoxal Phosphate; Serine | 2011 |
Rapid determination of free D-serine with chicken D-serine dehydratase.
Topics: Animals; Bombyx; Chickens; Chromatography, High Pressure Liquid; Colorimetry; Enzyme Assays; Hydro-Lyases; Larva; Linear Models; Organ Specificity; Pyridoxal Phosphate; Pyruvic Acid; Serine | 2011 |
Turning pyridoxal-5'-phosphate-dependent enzymes into thermostable binding proteins: D-Serine dehydratase from baker's yeast as a case study.
Topics: Amino Acid Sequence; Catalysis; Enzyme Stability; Escherichia coli; Holoenzymes; Hot Temperature; Hydro-Lyases; Kinetics; Molecular Sequence Data; Protein Engineering; Protein Structure, Secondary; Pyridoxal Phosphate; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Zinc | 2012 |
Formation of Schiff bases of O-phosphorylethanolamine and O-phospho-D,L-serine with pyridoxal 5'-phosphate. experimental and theoretical studies.
Topics: Ethanolamines; Molecular Structure; Pyridoxal Phosphate; Quantum Theory; Schiff Bases; Serine; Stereoisomerism | 2012 |
Metal ion dependency of serine racemase from Dictyostelium discoideum.
Topics: Calcium; Cations, Divalent; Cations, Monovalent; Cloning, Molecular; Dictyostelium; Escherichia coli; Kinetics; Magnesium; Mutation; Pyridoxal Phosphate; Racemases and Epimerases; Recombinant Proteins; Schizosaccharomyces; Sequence Homology, Amino Acid; Serine; Sodium; Stereoisomerism; Water | 2012 |
D-serine-dehydratase from Saccaromyces cerevisiae: a pyridoxal 5'- phosphate-dependent enzyme for advanced biotech applications.
Topics: Absorption; Biosensing Techniques; Fluorescein; Fluorescent Dyes; Hydro-Lyases; Models, Molecular; Pyridoxal Phosphate; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Spectrometry, Fluorescence | 2012 |
Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.
Topics: Animals; Arginine; Biocatalysis; Cytosol; Enzyme Stability; Glycine Hydroxymethyltransferase; Liver; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Binding; Pyridoxal Phosphate; Serine; Sheep; Temperature | 2003 |
Reconstitution of the pyridoxal 5'-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis.
Topics: Biocatalysis; Kinetics; Pyridoxal Phosphate; Serine; Serine C-Palmitoyltransferase; Sphingomonas; Substrate Specificity | 2013 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2013 |
Reaction mechanism of Zn2+-dependent d-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate.
Topics: Binding Sites; Biocatalysis; Catalytic Domain; Hydro-Lyases; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Mutation, Missense; Nitrogen; Protein Binding; Proteins; Pyridines; Pyridoxal Phosphate; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Spectrophotometry; Tyrosine; Zinc | 2014 |
Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations.
Topics: Alanine Racemase; Animals; Catalytic Domain; Humans; Malonates; Molecular Dynamics Simulation; Pyridoxal Phosphate; Racemases and Epimerases; Rats; Serine; Thermodynamics | 2015 |
Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH.
Topics: Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Glycine Hydroxymethyltransferase; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Protein Binding; Pyridoxal Phosphate; Serine; Threonine | 2015 |
The crystal structure of D-threonine aldolase from Alcaligenes xylosoxidans provides insight into a metal ion assisted PLP-dependent mechanism.
Topics: Acetaldehyde; Alanine Racemase; Alcaligenes; Aldehyde-Lyases; Bacterial Proteins; Binding Sites; Catalysis; Catalytic Domain; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Escherichia coli; Glycine; Manganese; Models, Molecular; Molecular Docking Simulation; Molecular Sequence Data; Multigene Family; Protein Conformation; Protein Structure, Tertiary; Protons; Pyridoxal Phosphate; Recombinant Proteins; Serine; Structure-Activity Relationship; Threonine | 2015 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary Supplements; Female; Glycine; Homocysteine; Humans; Kynurenine; Leucine; Methionine; Methylamines; Multivariate Analysis; Pyridoxal Phosphate; Pyridoxine; Serine; Tryptophan; Vitamin B 6 Deficiency; Young Adult | 2015 |
Distribution and evolution of the serine/aspartate racemase family in invertebrates.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Cloning, Molecular; Escherichia coli; Invertebrates; Phylogeny; Pyridoxal Phosphate; Racemases and Epimerases; Sequence Alignment; Sequence Analysis, DNA; Serine | 2016 |
Vitamin B6 is essential for serine de novo biosynthesis.
Topics: Brain; Cells, Cultured; Glycine; Humans; Pyridoxal Phosphate; Pyridoxine; Serine; Vitamin B 6; Vitamin B 6 Deficiency | 2017 |
Theoretical Evaluation of the Reaction Mechanism of Serine Hydroxymethyltransferase.
Topics: Biocatalysis; Catalytic Domain; Glycine Hydroxymethyltransferase; Models, Chemical; Molecular Dynamics Simulation; Plasmodium vivax; Pyridoxal Phosphate; Quantum Theory; Serine; Tetrahydrofolates | 2019 |
Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
Topics: Acyl Coenzyme A; Binding Sites; Biocatalysis; Cryoelectron Microscopy; Humans; Membrane Proteins; Models, Molecular; Multiprotein Complexes; Mutation; Pyridoxal Phosphate; Reproducibility of Results; Serine; Serine C-Palmitoyltransferase; Substrate Specificity | 2021 |
Identification and characterization of a serine racemase in the silkworm Bombyx mori.
Topics: Animals; Bombyx; Dehydration; Mammals; Pupa; Pyridoxal Phosphate; Racemases and Epimerases; Serine | 2022 |
Investigation of β-Substitution Activity of O-Acetylserine Sulfhydrolase from Citrullus vulgaris.
Topics: Citrullus; Cysteine Synthase; Mimosine; Pyridoxal Phosphate; Serine | 2022 |
Proteomic, Transcriptomic, Mutational, and Functional Assays Reveal the Involvement of Both THF and PLP Sites at the GmSHMT08 in Resistance to Soybean Cyst Nematode.
Topics: Animals; Carbon; Cysts; Glycine; Glycine Hydroxymethyltransferase; Glycine max; Glyoxylates; Heme; Methionine; Nematoda; Plant Diseases; Proteomics; Purines; Pyridoxal Phosphate; Serine; Tetrahydrofolates; Transcriptome | 2022 |
Crystal structure of Sphingobacterium multivorum serine palmitoyltransferase complexed with tris(hydroxymethyl)aminomethane.
Topics: Crystallography, X-Ray; Pyridoxal Phosphate; Serine; Serine C-Palmitoyltransferase; Tromethamine | 2022 |
Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization.
Topics: Brain; Humans; Pyridoxal Phosphate; Serine; Transaminases | 2023 |
Stereoselective Biocatalytic α-Deuteration of L-Amino Acids by a Pyridoxal 5'-Phosphate-Dependent Mannich Cyclase.
Topics: Amino Acids; Phosphates; Phylogeny; Pyridoxal; Pyridoxal Phosphate; Serine | 2023 |