serine and piperidines

serine has been researched along with piperidines in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (6.67)	18.7374
1990's	5 (11.11)	18.2507
2000's	21 (46.67)	29.6817
2010's	14 (31.11)	24.3611
2020's	2 (4.44)	2.80

Authors

Authors	Studies
Cler, JA; Contreras, PC; Dilworth, VM; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL	1
Ferkany, JW; Kaplita, PV	1
Cler, J; Contreras, PC; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL	1
Broomfield, CA; Hackley, BE; Morrisett, JD	1
Broomfield, CA; Morrisett, JD	1
Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G	1
Cascieri, MA; Chicchi, G; Davies, S; Elliott, JM; Kelleher, FJ; Kurtz, M; Ladduwahetty, T; Lewis, RT; MacLeod, AM; Merchant, KJ; Sadowski, S; Stevenson, GI	1
Broughton, H; Cascieri, MA; Chicchi, G; Elliott, JM; Huscroft, IT; Kurtz, M; MacLeod, AM; Sadowski, S; Stevenson, GI	1
Chai, YG; Cho, GW; Gilmor, ML; Hersh, LB; Kim, MH; Levey, AI	1
Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M	1
Ho, L; Mirjany, M; Pasinetti, GM	1
Bordeleau, M; Brooks, KM; Corbett, TJ; de Lannoy, I; Hendrix, JA; Kafka, S; Kamboj, RK; Kapples, KJ; Laws-Ricker, L; Lee, DK; Owolabi, J; Palermo, MG; Rizkalla, G; Shimshock, SJ; Shutske, GM; Tomer, JD; Vargas, HM	1
Chapman, DE; Keefe, KA; Wilcox, KS	1
Das, S; Murthy, KS; Zhou, H	1
Bryckaert, M; Contreres, JO; Dupuy, E; Habib, A; Herbert, JM; Job, B; Levy-Toledano, S; Rosa, JP; Savi, P; Simoneau, G	1
Clark, S; Leever, JD; Partin, KM; Weeks, AM	1
Lis, JT; Ni, Z; Schwartz, BE; Suarez, JR; Werner, J	1
Ahmed, SM; Chase, TN; Dunbar, GL; Menniti, FS; Oh, JD; Wessell, RH	1
de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M	1
Gyepesová, D; Koós, M; Langer, V; Micová, J; Steiner, B	1
Didriksen, M; Kreilgaard, M; Olsen, CK	1
Chung, S; Do, H; Kornfeld, SA; Powe, A; Steet, RA; Wustman, B	1
Duffy, S; Labrie, V; Roder, JC	1
Ahn, K; Alexander, JP; Arendse, A; Cravatt, BF; Fitzgerald, LR; Johnson, DS; Liimatta, M; Lund, ET; Nomanbhoy, TK; Nugent, RA; Stevenson, T	1
Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH	1
Concellón, C; Concellón, JM; Díaz, MR; España, E; García-Granda, S; Rivero, IA; Rodríguez-Solla, H	1
Bertani, S; Bifone, A; Crestan, V; Gozzi, A; Herdon, H; Schwarz, A; Turrini, G	1
Cho, GW; Kim, HY; Kim, SH; Kim, Y; Koh, SH; Noh, MY	1
Christophersen, P; Dale, TJ; Davies, DJ; Eriksen, BL; Hougaard, C; Jensen, ML; Miller, DD; Strøbaek, D; Trezise, DJ	1
Bélanger, N; Di Paolo, T; Hadj Tahar, A; Morissette, M; Samadi, P	1
Acharya, HP; Clive, DL	1
Bhadel, S; Carey, MF; Conaway, M; Ficarro, SB; Gioeli, D; Gordon, V; Hahn, WC; Hunt, DF; Mollah, SA; Shabanowitz, J; Wunderlich, W; Xenarios, I; Zhang, J	1
Kudaj, A; Lasota, A; Olma, A	1
Caracciolo, V; Carnevale, V; Cimini, AM; Crozier-Fitzgerald, C; Gentile Warschauer, E; Giordano, A; Laurenti, G; Romano, G; Russo, G	1
Doucette, CD; Hilchie, AL; Hoskin, DW; Liwski, R	1
Burkholder, TP; Geeganage, S; Gillig, J; Huss, K; Kuo, MS; Lu, ZH; Meier, TI; Parthasarathy, S; Roth, K; Shepard, RL; Smith, MC; Tan, B; Wang, T; Young, DA; Zhai, Y; Zhao, G	1
Akahoshi, F; Ishii, S; Kadowaki, T; Kishida, H; Miyaguchi, I; Nabeno, M; Tanaka, Y	1
Ou, M; Sandri-Goldin, RM	1
Chen, ZQ; Jiang, ZL; Li, X; Sun, L; Xu, LH; Yang, Y; Zhang, YF; Zhang, YY	1
Sinha, G	1
Chinta, G; Klopčič, I; Periyasamy, L; Ramya Chandar Charles, M; Selvaraj Coumar, M; Sollner Dolenc, M	1
Song, HI; Yoon, MS	1
Al-Khrasani, M; Balogh, M; Barsi, S; Hajnal, B; Harsing, LG; Király, K; Köles, L; Mohammadzadeh, A; Zádori, ZS	1
Huang, Y; Li, D; Sun, N; Wang, C; Yu, Q; Zhang, YX; Zhou, WX	1
Bressan, GC; da Silva, EQG; de Almeida Lima, GD; de Melo Agripino, J; de Oliveira Mendes, TA; de Oliveira, LL; de Paiva, JC; de Souza, APM; Fietto, JLR; Machado-Neves, M; Mendes, FC; Moreira, GA; Santos, MR; Silva, LVG; Silva-Júnior, A; Teixeira, RR	1

Reviews

1 review(s) available for serine and piperidines

Article	Year
Glycine transporter inhibitors: A new avenue for managing neuropathic pain. Brain research bulletin, 2019, Volume: 152 Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Neuralgia; Neuroglia; Neurons; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord Dorsal Horn; Synapses; Synaptic Transmission	2019

Other Studies

44 other study(ies) available for serine and piperidines

Article	Year
Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation of N-methyl-D-aspartate (NMDA) receptor complex-mediated events by sigma ligands. Brain research, 1991, Oct-04, Volume: 561, Issue:1 Topics: Animals; Cerebellum; Cyclic GMP; Dopamine Agents; Harmaline; Ligands; Male; Methamphetamine; Mice; Pentylenetetrazole; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Serine	1991
Evidence for direct interactions between the NMDA and glycine recognition sites in brain. European journal of pharmacology, 1990, Mar-13, Volume: 188, Issue:2-3 Topics: Amino Acids; Animals; Brain Chemistry; In Vitro Techniques; Kynurenic Acid; Male; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine	1990
Ifenprodil and SL 82.0715 antagonize N-methyl-D-aspartate (NMDA)-coupled glycine receptor responses in vivo. European journal of pharmacology, 1989, Sep-01, Volume: 168, Issue:1 Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Cyclic GMP; Glycine; Injections; Male; Mice; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Time Factors	1989
A new spin label specific for the active site of serine enzymes. The Journal of biological chemistry, 1969, Oct-25, Volume: 244, Issue:20 Topics: Acetylcholinesterase; Animals; Binding Sites; Brain Chemistry; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Fluorine; Free Radicals; Humans; Nerve Endings; Organophosphonates; Piperidines; Rats; Serine	1969
A comparative study of spin-labeled serine enzymes: acetylcholinesterase, trypsin, -chymotrypsin, elastase, and subtilisin. The Journal of biological chemistry, 1972, Nov-25, Volume: 247, Issue:22 Topics: Acetylcholinesterase; Binding Sites; Chymotrypsin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Endopeptidases; Fluorine; Hydrogen-Ion Concentration; Indicators and Reagents; Organophosphorus Compounds; Pancreatic Elastase; Piperidines; Protein Binding; Serine; Subtilisins; Trypsin	1972
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. Journal of neurochemistry, 1998, Volume: 70, Issue:3 Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis	1998
Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents. Bioorganic & medicinal chemistry letters, 1998, Jul-21, Volume: 8, Issue:14 Topics: Neurokinin-1 Receptor Antagonists; Piperidines; Serine; Stereoisomerism; Structure-Activity Relationship	1998
Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding. Bioorganic & medicinal chemistry letters, 1998, Jul-21, Volume: 8, Issue:14 Topics: Models, Chemical; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Serine; Structure-Activity Relationship; Sulfonamides	1998
Phosphorylation of the rat vesicular acetylcholine transporter. The Journal of biological chemistry, 2000, Jun-30, Volume: 275, Issue:26 Topics: Acetylcholine; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Carrier Proteins; Cell Nucleus; Centrifugation, Density Gradient; Cytoplasm; Immunoblotting; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuromuscular Depolarizing Agents; PC12 Cells; Phosphorylation; Piperidines; Precipitin Tests; Protein Kinase C; Protein Structure, Tertiary; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Synaptophysin; Transfection; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	2000
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition. Journal of neurochemistry, 2001, Volume: 76, Issue:1 Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc	2001
Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2 Topics: Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cerebral Cortex; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinases; Cyclooxygenase 2; Enzyme Inhibitors; Excitatory Amino Acid Agents; Female; Flavonoids; Glutamic Acid; Isoenzymes; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Retinoblastoma Protein; RNA, Messenger; Serine; Sulfonamides; Tumor Suppressor Proteins	2002
Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists. Chembiochem : a European journal of chemical biology, 2002, Oct-04, Volume: 3, Issue:10 Topics: Administration, Oral; Animals; Apomorphine; Benzyl Compounds; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Indoles; Infusions, Parenteral; Isoxazoles; Piperidines; Prazosin; Rats; Receptors, Dopamine D4; Serine; Spiperone; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity	2002
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Journal of neurophysiology, 2003, Volume: 89, Issue:1 Topics: Age Factors; Animals; Animals, Newborn; Corpus Striatum; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Kinetics; Limbic System; Male; Motor Neurons; Neurons, Afferent; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synapses	2003
Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 284, Issue:3 Topics: Acetylcholine; Animals; cdc42 GTP-Binding Protein; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phospholipase D; Phospholipases A; Phosphorylation; Piperidines; Protein Serine-Threonine Kinases; Rabbits; rac1 GTP-Binding Protein; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Serine; Signal Transduction	2003
Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP. British journal of haematology, 2003, Volume: 120, Issue:4 Topics: Adenosine Diphosphate; Adolescent; Adult; Benzylamines; Blood Platelets; Clopidogrel; Electrophoresis, Polyacrylamide Gel; Humans; Male; Membrane Proteins; Phosphorylation; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serine; Signal Transduction; Thiazoles; Thionucleotides; Threonine; Ticlopidine; Tyrosine	2003
Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization. Molecular pharmacology, 2003, Volume: 64, Issue:1 Topics: Amino Acid Substitution; Animals; Benzothiadiazines; Binding Sites; Dioxoles; Glutamic Acid; Kinetics; Models, Molecular; Oocytes; Piperidines; Point Mutation; Receptors, AMPA; Serine; Threonine; Transfection; Xenopus laevis	2003
Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes. Molecular cell, 2004, Jan-16, Volume: 13, Issue:1 Topics: Animals; Cells, Cultured; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Flavonoids; Heat-Shock Proteins; Hot Temperature; HSP70 Heat-Shock Proteins; Models, Genetic; Phosphorylation; Piperidines; Positive Transcriptional Elongation Factor B; Protein Structure, Tertiary; RNA; RNA Polymerase II; RNA Processing, Post-Transcriptional; RNA, Small Interfering; Serine; Transcription, Genetic	2004
NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemi-parkinsonian rats. Neuropharmacology, 2004, Volume: 47, Issue:2 Topics: Animals; Excitatory Amino Acid Antagonists; Functional Laterality; Levodopa; Locomotion; Male; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rotation; Serine; Stereotyped Behavior; Sympathectomy, Chemical	2004
Structural determinants of HERG channel block by clofilium and ibutilide. Molecular pharmacology, 2004, Volume: 66, Issue:2 Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis	2004
Synthesis and structure determination of some nonanomerically C-C-linked serine glycoconjugates structurally related to mannojirimycin. Carbohydrate research, 2004, Sep-13, Volume: 339, Issue:13 Topics: Crystallography, X-Ray; Glycoconjugates; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Serine; Structure-Activity Relationship	2004
Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:2 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Conditioning, Psychological; Dioxoles; Drug Synergism; Isoxazoles; Male; Olanzapine; Paliperidone Palmitate; Piperidines; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Risperidone; Serine; Stereoisomerism	2006
The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-12, Volume: 103, Issue:37 Topics: Asparagine; Binding Sites; Catalysis; Cells, Cultured; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gaucher Disease; Glucosylceramidase; Humans; Hydrogen-Ion Concentration; Imino Pyranoses; Lysosomes; Mutation; Piperidines; Protein Folding; Serine; Sodium Dodecyl Sulfate	2006
D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:5 Topics: Analysis of Variance; Animals; Aspartic Acid; Avoidance Learning; Behavior, Animal; Carrier Proteins; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Serine; Spatial Behavior	2008
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry, 2007, Nov-13, Volume: 46, Issue:45 Topics: Amidohydrolases; Anilides; Animals; Benzamides; Binding Sites; Carbamates; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mice; Piperazines; Piperidines; Serine; Time Factors	2007
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular pharmacology, 2008, Volume: 74, Issue:3 Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan	2008
Totally selective synthesis of enantiopure (3S,5S)- and (3R,5R)-4-amino-3,5-dihydroxypiperidines from aminodiepoxides derived from serine. The Journal of organic chemistry, 2008, Aug-01, Volume: 73, Issue:15 Topics: Amines; Epoxy Compounds; Molecular Structure; Piperidines; Serine; Stereoisomerism	2008
Pharmacological stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat. Psychopharmacology, 2008, Volume: 201, Issue:2 Topics: Animals; Benzamides; Binding Sites; Blood Volume; Brain; Dose-Response Relationship, Drug; Glycine; Glycine Plasma Membrane Transport Proteins; Injections, Intravenous; Magnetic Resonance Imaging; Male; Models, Theoretical; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Time Factors	2008
Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. Journal of neurochemistry, 2009, Volume: 108, Issue:5 Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Embryo, Mammalian; Glycogen Synthase Kinase 3; Indans; Indoles; Mecamylamine; Morpholines; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Serine; Sincalide	2009
Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Molecular pharmacology, 2009, Volume: 76, Issue:3 Topics: Amino Acid Substitution; Carbamates; Cell Line; Humans; Mutation; Piperidines; Serine; Small-Conductance Calcium-Activated Potassium Channels	2009
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys. Progress in neuro-psychopharmacology & biological psychiatry, 2010, Apr-16, Volume: 34, Issue:3 Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cabergoline; Corpus Striatum; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Ergolines; Female; Glycogen Synthase Kinase 3; Levodopa; Macaca fascicularis; Oncogene Protein v-akt; Parkinsonian Disorders; Phosphorylation; Piperidines; Serine; Signal Transduction; Statistics as Topic	2010
2,6-Disubstituted and 2,2,6-trisubstituted piperidines from serine: asymmetric synthesis and further elaboration. The Journal of organic chemistry, 2010, Aug-06, Volume: 75, Issue:15 Topics: Magnetic Resonance Spectroscopy; Oxidation-Reduction; Piperidines; Serine; Spectroscopy, Fourier Transform Infrared	2010
CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation. Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:12 Topics: Androgen Receptor Antagonists; Androgens; Animals; Cell Growth Processes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cyclin T; Cyclin-Dependent Kinase 9; Dichlororibofuranosylbenzimidazole; Flavonoids; Gene Knockdown Techniques; HeLa Cells; Humans; Phosphorylation; Piperidines; Promoter Regions, Genetic; Receptors, Androgen; RNA, Small Interfering; Serine; Serine Endopeptidases; Transfection	2010
A convenient route to optically pure α-alkyl-β-(sec-amino)alanines. Amino acids, 2012, Volume: 42, Issue:6 Topics: Alanine; Cyclization; Lactones; Morpholines; Piperidines; Pyrrolidines; Serine; Stereoisomerism	2012
Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development. Cell cycle (Georgetown, Tex.), 2012, Mar-15, Volume: 11, Issue:6 Topics: Blotting, Western; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drug Design; Enzyme Activation; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Humans; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; RNA Polymerase II; RNA, Small Interfering; Serine; Signal Transduction; Time Factors	2012
Piperine, a dietary phytochemical, inhibits angiogenesis. The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:1 Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Aorta; Benzodioxoles; Breast Neoplasms; Cell Movement; Cell Proliferation; Chick Embryo; Chromones; Drug Screening Assays, Antitumor; Female; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Male; Morpholines; Neovascularization, Pathologic; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats, Wistar; S Phase; Serine; Threonine; TRPV Cation Channels	2013
Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. The Journal of biological chemistry, 2013, Feb-01, Volume: 288, Issue:5 Topics: Acrylamides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Death; Cell Line, Tumor; Citric Acid Cycle; Enzyme Inhibitors; Female; Glycolysis; Humans; Isotope Labeling; Mice; Mice, SCID; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Pentose Phosphate Pathway; Piperidines; Serine; Xenograft Model Antitumor Assays	2013
A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site. Biochemical and biophysical research communications, 2013, May-03, Volume: 434, Issue:2 Topics: Adamantane; Catalytic Domain; Crystallography, X-Ray; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Multiprotein Complexes; Nitriles; Oligopeptides; Piperidines; Protein Binding; Protein Interaction Mapping; Pyrazines; Pyrazoles; Pyrrolidines; Serine; Sitagliptin Phosphate; Structure-Activity Relationship; Thiazolidines; Triazoles; Uracil; Vildagliptin; X-Ray Diffraction	2013
Inhibition of cdk9 during herpes simplex virus 1 infection impedes viral transcription. PloS one, 2013, Volume: 8, Issue:10 Topics: Cyclin-Dependent Kinase 9; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Flavonoids; Genes, Viral; HeLa Cells; Herpesvirus 1, Human; Humans; Phosphorylation; Piperidines; Protein Structure, Tertiary; RNA Polymerase II; RNA-Binding Proteins; Serine; Transcription Factors; Transcription, Genetic; Virus Replication	2013
D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent. CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:11 Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine	2014
Overcoming mantle cell lymphoma's ibrutinib resistance. Journal of the National Cancer Institute, 2014, Volume: 106, Issue:11 Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclin-Dependent Kinases; Cysteine; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; Mutation; Piperazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Serine	2014
In Silico and In Vitro Investigation of the Piperine's Male Contraceptive Effect: Docking and Molecular Dynamics Simulation Studies in Androgen-Binding Protein and Androgen Receptor. Planta medica, 2015, Volume: 81, Issue:10 Topics: Alkaloids; Androgen-Binding Protein; Benzodioxoles; Catalytic Domain; Cell Line; Computer Simulation; Contraceptive Agents, Male; Dihydrotestosterone; Humans; Hydrogen Bonding; Male; Metribolone; Molecular Docking Simulation; Molecular Dynamics Simulation; Piperidines; Polyunsaturated Alkamides; Protein Conformation; Receptors, Androgen; Serine	2015
PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639. Scientific reports, 2016, 11-22, Volume: 6 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Benzimidazoles; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Phosphatidic Acids; Phospholipase D; Phosphorylation; Piperidines; RNA Interference; RNA, Small Interfering; Serine; TOR Serine-Threonine Kinases	2016
Reduced D-Serine Release May Contribute to Impairment of Long-Term Potentiation by Corticosterone in the Perforant Path-Dentate Gyrus. Neurochemical research, 2021, Volume: 46, Issue:9 Topics: Animals; Corticosterone; Dentate Gyrus; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Open Field Test; Perforant Pathway; Phenols; Piperidines; Quinolones; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Serine	2021
Immunomodulatory activity of trifluoromethyl arylamides derived from the SRPK inhibitor SRPIN340 and their potential use as vaccine adjuvant. Life sciences, 2022, Oct-15, Volume: 307 Topics: Adjuvants, Immunologic; Adjuvants, Vaccine; Animals; Antibodies, Neutralizing; Antiviral Agents; Arginine; Dipeptides; Immunity; Mice; Niacinamide; Piperidines; Protein Isoforms; Protein Serine-Threonine Kinases; RNA Splicing Factors; Serine; Vaccines	2022