serine has been researched along with penicillanic acid in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knott-Hunziker, V; Orlek, BS; Sammes, PG; Waley, SG | 1 |
| Dunbar, B; Horrocks, AJ; Lindsay, CD; Slade, A; Virden, R | 1 |
| Dusart, J; Frère, JM; Jacob, F; Joris, B; Lepage, S | 1 |
| Day, RA; Heckler, TG | 1 |
| Frère, JM; Joris, B; Ledent, P; Raquet, X; Van Beeumen, J | 1 |
| Aplin, RT; Brown, RP; Schofield, CJ | 1 |
| Amicosante, G; Bianchi, C; Bonfiglio, G; Franceschini, N; Nicoletti, G; Perez, MM; Perilli, M; Segatore, B; Stefani, S; Zollo, A | 1 |
| Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM | 1 |
| Anderson, VE; Bethel, CR; Bonomo, RA; Guo, B; Helfand, MS; Hujer, AM; Jin, Z; Ng, LM; Pagan-Rodriguez, D; Simmons, R; Zhou, X | 1 |
| Bethel, CR; Bonomo, RA; Knox, JR; Sun, T | 1 |
| Bonomo, RA; Carey, MP; Carey, PR; Helfand, MS; Padayatti, PS; Totir, MA; van den Akker, F | 1 |
| Fisher, JF; Meroueh, SO; Mobashery, S; Schlegel, HB | 1 |
| Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F | 1 |
| Bonomo, RA; Buynak, JD; Carey, MP; Carey, PR; Helfand, MS; Sheri, A; Totir, MA | 1 |
| Adediran, SA; Dzhekieva, L; Pratt, RF | 1 |
15 other study(ies) available for serine and penicillanic acid
| Article | Year |
|---|---|
Penicillinase active sites: labelling of serine-44 in beta-lactamase I by 6beta-bromopenicillanic acid.
Topics: Affinity Labels; beta-Lactamases; Binding Sites; Penicillanic Acid; Penicillinase; Peptide Fragments; Serine; Spectrophotometry, Ultraviolet | 1979 |
Site-directed chemical conversion of serine to cysteine in penicillin acylase from Escherichia coli ATCC 11105. Effect on conformation and catalytic activity.
Topics: Amino Acid Sequence; Circular Dichroism; Cysteine; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Penicillanic Acid; Penicillin Amidase; Phenylmethylsulfonyl Fluoride; Protein Conformation; Pyridines; Serine; Sulfur Radioisotopes | 1991 |
Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; beta-Lactamases; Binding Sites; Chemical Phenomena; Chemistry, Physical; Enzyme Stability; Hot Temperature; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Penicillanic Acid; Serine; Streptomyces; Structure-Activity Relationship; Thermodynamics | 1990 |
Bacillus cereus 569/H penicillinase serine-44 acylation by diazotized 6-aminopenicillanic acid.
Topics: Acylation; Affinity Labels; Amino Acids; Bacillus cereus; beta-Lactamases; Chemical Phenomena; Chemistry; Mass Spectrometry; Penicillanic Acid; Penicillinase; Peptide Fragments; Protein Binding; Serine; Spores, Bacterial | 1983 |
A comparative study of class-D beta-lactamases.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Catalysis; Chromatography, Affinity; Chromatography, Ion Exchange; Cloning, Molecular; Kinetics; Penicillanic Acid; Plasmids; Serine; Substrate Specificity | 1993 |
Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Clavulanic Acids; Dithiothreitol; Enzyme Inhibitors; Escherichia coli; Kinetics; Mass Spectrometry; Models, Chemical; Molecular Structure; Penicillanic Acid; Serine; Serine Endopeptidases; Trypsin | 1996 |
A kinetic study on the interaction between tazobactam (a penicillanic acid sulphone derivative) and active-site serine beta-lactamases.
Topics: Acinetobacter; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Citrobacter; Enzyme Inhibitors; Escherichia coli; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Morganella; Mycobacterium fortuitum; Penicillanic Acid; Providencia; Pseudomonas aeruginosa; Serine; Serratia marcescens; Tazobactam | 2000 |
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors | 2003 |
Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition.
Topics: beta-Lactamases; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Kinetics; Mass Spectrometry; Models, Chemical; Penicillanic Acid; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tazobactam; Trypsin | 2004 |
Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant.
Topics: Alanine; Amino Acid Substitution; Apoenzymes; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Binding Sites; Catalysis; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli Proteins; Genetic Variation; Glutamic Acid; Glycine; Hydrolysis; Models, Molecular; Mutagenesis, Site-Directed; Penicillanic Acid; Serine; Tazobactam | 2004 |
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.
Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Binding Sites; Clavulanic Acid; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Klebsiella pneumoniae; Models, Chemical; Models, Molecular; Mutation; Penicillanic Acid; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam; Time Factors; X-Rays | 2005 |
Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.
Topics: Acylation; beta-Lactamases; Glutamic Acid; Lysine; Models, Molecular; Penicillanic Acid; Serine; Thermodynamics | 2005 |
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam | 2007 |
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.
Topics: Acrylates; Amino Acid Substitution; beta-Lactamases; Catalytic Domain; Clavulanic Acid; Crystallization; Enzyme Inhibitors; Imines; Kinetics; Molecular Structure; Penicillanic Acid; Recombinant Proteins; Serine; Spectrum Analysis, Raman; Sulbactam; Tazobactam | 2007 |
Interactions of "bora-penicilloates" with serine β-lactamases and DD-peptidases.
Topics: Acylation; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Biocatalysis; Boronic Acids; Catalytic Domain; Drug Design; Isoenzymes; Kinetics; Membrane Proteins; Models, Molecular; Molecular Conformation; Penicillanic Acid; Penicillin-Binding Proteins; Serine; Serine Endopeptidases; Serine Proteinase Inhibitors | 2014 |