serine has been researched along with okadaic acid in 124 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 40 (32.26) | 18.2507 |
| 2000's | 64 (51.61) | 29.6817 |
| 2010's | 20 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lerea, KM | 1 |
| Miyasaka, J; Miyasaka, T; Saltiel, AR | 1 |
| Mimnaugh, EG; Neckers, LM; Whitesell, L; Worland, PJ | 1 |
| Bagrodia, S; Chackalaparampil, I; Shalloway, D | 1 |
| Ku, NO; Omary, MB | 1 |
| Aperia, A; Celsi, G; da Cruz e Silva, EF; Durbeej, M; Ekblom, P; Laestadius, A; Svennilson, J | 1 |
| Hisanaga, S; Hosoi, T; Ishiguro, K; Kishimoto, T; Okumura, E; Okuyama, A; Saito, T; Uchida, T; Uchiyama, M | 1 |
| Guy, GR; Menon, SD; Tan, YH | 1 |
| Baeuerle, PA; Henkel, T; Pahl, HL; Schmidt, KN; Traenckner, EB; Wilk, S | 1 |
| Terrian, DM; Ways, DK | 1 |
| Brautigan, DL; Pinault, FM | 1 |
| Cormont, M; Le Marchand-Brustel, Y; Tanti, JF; Van Obberghen, E; Zahraoui, A | 1 |
| Grémeaux, T; Le Marchand-Brustel, Y; Tanti, JF; van Obberghen, E | 1 |
| Baggio, B; Bordin, L; Clari, G; Gambaro, G; Moret, V | 1 |
| Erikson, RL; Hill, DE; Johnson, KA; Paige, LA; Schievella, AR | 1 |
| Agnew, WS; Bendahhou, S; Cummins, TR; Potts, JF; Tong, J | 1 |
| Mothe, I; Van Obberghen, E | 1 |
| Baeuerle, PA; Traenckner, EB | 1 |
| Artçanuthurry, V; Grelac, F; Levy-Tolédano, S; Maclouf, J; Martin-Cramer, E | 1 |
| de Cingolani, GC; Mattiazzi, A; Mundiña-Weilenmann, C; Ortale, M; Vittone, L | 1 |
| Londos, C; Rondinone, CM; Smith, UP; Zarnowski, MJ | 1 |
| da-Costa-Maia, JC; da-Silva, AM; Terenzi, HF; Zapella, PD | 1 |
| Ku, NO; Liao, J; Omary, MB | 1 |
| Lee, VM; Merrick, SE; Trojanowski, JQ | 1 |
| Ferreri, NR; Mahboubi, K; Young, W | 1 |
| Ha, KS; Jung, HI; Kang, KW; Park, YM; Shin, I | 1 |
| Aizman, O; Aizman, R; Aperia, A; Cheng, XJ; Fisone, G; Greengard, P; Levenson, R | 1 |
| Lau, LF; Li, Y | 1 |
| Badiani, K; Byers, DM; Cook, HW; Ridgway, ND | 1 |
| Chrispeels, MJ; Johansson, I; Karlsson, M; Kjellbom, P; Larsson, C; Shukla, VK | 1 |
| Chun, RF; Jeang, KT; Neuveut, C; Semmes, OJ | 1 |
| Berggren, PO; Bertorello, AM; Chibalin, AV; Féraille, E; Katz, AI; Pedemonte, CH | 1 |
| Basu, A; Croce, CM; Haldar, S | 1 |
| Hanada, M; Ikeda, S; Kobayashi, T; Kusuda, K; Ohnishi, M; Tamura, S; Wang, H; Yanagawa, Y | 1 |
| Hayashi, H; Inoue, R; Kagamiyama, H; Nishito, Y; Shimizu, M; Takeda, M; Tanabe, O; Usui, H | 1 |
| Bragado, MJ; Ernst, SA; Groblewski, GE; Leykam, J; Williams, JA; Yoshida, M | 1 |
| Carr, B; Deng, X; Ito, T; May, WS; Mumby, M | 1 |
| Nayler, O; Schnorrer, F; Stamm, S; Ullrich, A | 1 |
| Cengel, KA; Freund, GG | 1 |
| Bize, I; Brugnara, C; Buchbinder, G; Güvenç, B; Robb, A | 1 |
| Kanaho, Y; Watanabe, H | 1 |
| Chang, SJ; Chen, JY; Chen, MR; Huang, H | 1 |
| Ball, KL; Morrice, N; Scott, MT | 1 |
| Brunati, AM; Donella-Deana, A; Marin, O; Pinna, LA; Ruzzene, M; Sarno, S | 1 |
| Fisone, G; Goiny, M; Goldstein, M; Haycock, J; Herrera-Marschitz, M; Hökfelt, T; Lindgren, N; Lindskog, M; Xu, ZQ | 1 |
| Allen, PB; Fienberg, AA; Greengard, P; Huganir, RL; Nairn, AC; Snyder, GL; Valle, CG | 1 |
| Bonventre, JV; Gijón, MA; Leslie, CC; Siddiqi, AR; Spencer, DM | 1 |
| Hayashi, Y; Komeima, K; Naito, Y; Watanabe, Y | 1 |
| Davare, MA; Hell, JW; Horne, MC | 1 |
| Bartel, S; Karczewski, P; Krause, EG; Schlegel, WP; Vetter, D; Wallukat, G | 1 |
| Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J | 1 |
| Kramer, DL; Pederson, TM; Rondinone, CM | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Bennecib, M; Gong, CX; Grundke-Iqbal, I; Iqbal, K | 1 |
| Borchers, CH; Jeyarajah, S; Martin, KJ; Merrick, BA; Parker, CE; Selkirk, JK; Tomer, KB; Zhou, W | 1 |
| Anguissola, S; Comoglio, PM; Giordano, S; Gual, P; Parker, PJ | 1 |
| Correia, MA; Maltby, D; Medzihradszky, KF; Wang, X | 1 |
| Halestrap, AP; Lockyer, PJ; Moule, SK; O'toole, A | 1 |
| Chung, HJ; Huganir, RL; Kim, CH; Lee, HK | 1 |
| Kumar, R; Mandal, M; Mazumdar, A; Mishra, SK | 1 |
| Abraham, D; Baccarini, M; Eulitz, M; Kubicek, M; Pacher, M; Podar, K | 1 |
| Jin, P; Levitan, IB; Weiger, TM; Wu, Y | 1 |
| Bakó, E; Bíró, T; Czifra, G; Felszeghy, S; Gergely, P; Módis, L; Szucs, K; Zákány, R | 1 |
| Cenni, V; Döppler, H; Maraldi, N; Newton, AC; Sonnenburg, ED; Toker, A | 1 |
| Becker, S; Klenk, HD; Modrof, J; Mühlberger, E | 1 |
| Bertrand, L; Hue, L; Krause, U | 1 |
| Greif, DM; Kou, R; Michel, T | 1 |
| Armstrong, DL; Birnbaumer, L; Darden, T; Erxleben, C; Gomez-Alegria, C; Mori, Y | 1 |
| Akhand, AA; Ishikawa, N; Itoigawa, M; Kato, M; Kawamoto, Y; Liu, W; Nakashima, I; Suzuki, H; Takeda, K | 1 |
| Griendling, KK; Rocic, P; Seshiah, P | 1 |
| Corces, VG; Nowak, SJ; Pai, CY | 1 |
| Brady, JN; Dohoney, KM; Elbi, C; Guillerm, C; Hager, GL; Lambert, PF; Whiteford, C | 1 |
| Kinoshita, K; McConnell, SK; Schaar, BT | 1 |
| Pestell, RG; Pradeep, A; Rana, B; Sharma, C | 1 |
| Bui, HT; Miyano, T; Yamaoka, E | 1 |
| Carlson, CJ; Rondinone, CM; White, MF | 1 |
| Donini, M; Dusi, S; Margotto, D; Mazzi, P; Wientjes, F | 1 |
| Gautier, N; Hinault, C; Lawrence, JC; Mothe-Satney, I; Van Obberghen, E | 1 |
| Douglas, P; Goodarzi, AA; Jonnalagadda, JC; Khanna, KK; Lees-Miller, SP; Moorhead, GB; Ye, R; Young, D | 1 |
| Arora, A; Choe, ES; Fibuch, EE; Liu, Z; Mao, L; Wang, JQ; Yang, L; Zhang, G | 1 |
| Bai, RY; Bassermann, F; Duyster, J; Münch, S; Peschel, C; Urschel, S | 1 |
| Kikuchi, K; Mitsuhashi, S; Onoe, K; Sasa, S; Shima, H; Tanuma, N; Ubukata, M | 1 |
| Baran, V; Kalous, J; Kubelka, M; Motlik, J; Schultz, RM; Solc, P | 1 |
| Kato, H; Ohne, Y; Toyoshima, Y | 1 |
| Matts, RL; Yun, BG | 1 |
| Coleman, KG; Du, P; Geoghegan, KF; LeMotte, PK; Loulakis, P; Luo, C; Mistry, A; Rafidi, K; Rajamohan, F; Simons, SP; Xie, Z | 1 |
| Bhattacharya, S; Johnson, LR; Ray, RM | 1 |
| Dietrich, P; Peng, X; Peng, XM; Perez, RG; Stefanis, L; Tehranian, R | 1 |
| Fukazawa, Y; Gao, Y; Hamabe, W; Kishioka, S; Kumamoto, K; Maeda, T; Ozaki, M | 1 |
| Ballard, DW; Carter, RS; Gomez, RJ; Khan, WN; Kray, AE; Llanes, JM; Pennington, KN; Sanders, LE; Wadzinski, BE | 1 |
| Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P | 1 |
| Chen, CS; Lin, HP; Tseng, PH; Weng, SC | 1 |
| Frolkis, M; Gong, X; Ku, NO; Nakamichi, I; Omary, MB; Pytela, R; Tao, GZ; Wang, J; Zhu, W | 1 |
| McKeown-Longo, PJ; Zheng, M | 1 |
| Aglipay, JA; Lee, SW; Martin, SA; Ouchi, T; Tawara, H | 1 |
| Michie, SA; Omary, MB; Strnad, P; Tao, GZ; Toivola, DM; Xu, B; Zhou, Q | 1 |
| Arora, A; Fibuch, EE; Kingston, S; Mao, L; Wang, JQ; Yang, L | 1 |
| Bednorz, A; Didié, M; Ditz, D; Dobrev, D; El-Armouche, A; Eschenhagen, T; Pamminger, T | 1 |
| Amorim, BR; Haneji, T; Morimoto, H; Okamura, H; Ozaki, A; Tanaka, H; Yoshida, K | 1 |
| Albigès-Rizo, C; Block, MR; Garcia, A; Horn, V; Thélu, J; Viallet, J | 1 |
| Brancolini, C; Cernotta, N; Dello Russo, C; Foti, C; Gallinari, P; Orsatti, L; Pallaoro, M; Paroni, G; Steinkühler, C; Talamo, F | 1 |
| Ares, IR; Botana, LM; Cagide, E; Louzao, MC; Vieytes, MR; Vilariño, N; Yasumoto, T | 1 |
| Minchin, RF; Mitchell, DJ | 1 |
| Hivert, V; Pierre, J; Raingeaud, J | 1 |
| Azarkeivan, A; Hayat, P; Kazemi, A; Safa, M; Zaker, F; Zand, H | 1 |
| Amezcua-Romero, JC; Pantoja, O; Vera-Estrella, R | 1 |
| Choe, H; Choi, JE; Kim, DH; Kim, SM; Lee, HS; Lee, SC; Lim, YW; Yoon, SY | 1 |
| Hashimoto, YK; Horike, N; Takemori, H; Tamura, M; Uebi, T | 1 |
| Chathoth, S; Galadari, S; Hago, A; Kizhakkayil, J; Patel, M; Shahin, A; Thayyullathil, F | 1 |
| Doll, C; Pöll, F; Schulz, S | 1 |
| Bassell, GJ; Gross, C; Muddashetty, RS; Nalavadi, VC | 1 |
| Diamond, MI; Shao, J | 1 |
| Huber, KM; Niere, F; Wilkerson, JR | 1 |
| Corbin, KD; Eichler, DC; Haines, RJ; Pendleton, LC | 1 |
| Kahn-Perlès, B; Kasai, S; Kikuchi, H; Shimoyama, S | 1 |
| Amsailale, R; Beyaert, M; Bontemps, F; Janssens, V; Smal, C; Van Den Neste, E | 1 |
| Gray, EE; Guglietta, R; Khakh, BS; O'Dell, TJ | 1 |
| Bhowmik, A; Chatterjee, A; Chatterjee, S; Chatterjee, U; Ghosh, MK; Mandal, T | 1 |
| Craig, RW; Kasof, G; Nifoussi, SK; Ornstein, DL; Ratcliffe, NR; Strack, S | 1 |
| Chang, RC; Ho, YS; Huang, C; Irwin, MG; Ng, OT; Wong, GT | 1 |
| Arias, EB; Cartee, GD; Sharma, P | 1 |
| Li, J; Tang, DD; Wang, R | 1 |
| Chen, F; Gong, CX; Gu, J; Hu, W; Iqbal, K; Liu, F; Miao, S; Wang, W; Wu, F | 1 |
| Boudreau, CG; Brown, CM; Khadra, A; Tang, K | 1 |
124 other study(ies) available for serine and okadaic acid
| Article | Year |
|---|---|
Thrombin-induced effects are selectively inhibited following treatment of intact human platelets with okadaic acid.
Topics: Blood Platelets; Carrier Proteins; Endoribonucleases; Ethers, Cyclic; Humans; Intracellular Signaling Peptides and Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Proteins; RNA-Binding Proteins; Serine; Serotonin; Threonine; Thrombin | 1991 |
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; Ethers, Cyclic; Nerve Growth Factors; Okadaic Acid; Pheochromocytoma; Phosphorylation; Protein Kinases; Serine; Swine; Threonine; Tumor Cells, Cultured | 1990 |
Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase.
Topics: 3T3 Cells; Animals; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Ethers, Cyclic; HSP90 Heat-Shock Proteins; Mice; Okadaic Acid; Oncogene Protein pp60(v-src); Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Serine; Threonine | 1995 |
Tyrosine dephosphorylation of pp60c-src is stimulated by a serine/threonine phosphatase inhibitor.
Topics: 3T3 Cells; Animals; Enzyme Activation; Ethers, Cyclic; Fibroblasts; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Serine; Threonine; Tyrosine | 1994 |
Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Ethers, Cyclic; Humans; Intermediate Filaments; Keratins; Mice; Molecular Sequence Data; Mutation; Okadaic Acid; Peptide Mapping; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Spodoptera | 1994 |
Evidence for a role of protein phosphatases 1 and 2A during early nephrogenesis.
Topics: Animals; Base Sequence; Carrier Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Enzyme Inhibitors; Ethers, Cyclic; Female; Immunoblotting; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Kidney; Molecular Sequence Data; Morphogenesis; Okadaic Acid; Phosphoprotein Phosphatases; Pregnancy; Proteins; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1995 |
Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract.
Topics: 4-Butyrolactone; Adenosine Triphosphate; Animals; Blotting, Western; Brain; Brain Chemistry; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Electrophoresis; Enzyme Inhibitors; Ethers, Cyclic; Guanosine Triphosphate; Microtubules; Okadaic Acid; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Serine; Swine; tau Proteins; Tissue Extracts | 1995 |
Involvement of a putative protein-tyrosine phosphatase and I kappa B-alpha serine phosphorylation in nuclear factor kappa B activation by tumor necrosis factor.
Topics: Amino Acid Sequence; Base Sequence; Cell Line, Transformed; DNA; DNA-Binding Proteins; Ethers, Cyclic; Humans; I-kappa B Proteins; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Phosphorylation; Protein Tyrosine Phosphatases; Serine; Serine Proteinase Inhibitors; Tumor Necrosis Factor-alpha | 1995 |
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.
Topics: Base Sequence; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Humans; I-kappa B Proteins; Molecular Sequence Data; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oligopeptides; Phosphoprotein Phosphatases; Phosphorylation; Point Mutation; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Serine; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Necrosis Factor-alpha | 1995 |
Persistent enhancement of sustained calcium-dependent glutamate release by phorbol esters: role of calmodulin-independent serine/threonine phosphorylation and actin disassembly.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Barium; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cytochalasin D; Ethers, Cyclic; Glutamates; Guinea Pigs; Hippocampus; Isoquinolines; Male; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Serine; Sphingosine; Staurosporine; Subcellular Fractions; Sulfonamides; Synaptosomes; Threonine | 1995 |
Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid.
Topics: Amino Acid Sequence; Blotting, Western; Cell Membrane; Chromatography, Gel; Cyanogen Bromide; Cyclic AMP; Diglycerides; Ethers, Cyclic; Female; HeLa Cells; Humans; Macromolecular Substances; Molecular Sequence Data; Okadaic Acid; Peptide Fragments; Phosphopeptides; Phosphorylation; Phosphoserine; Placenta; Pregnancy; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Serine; Thionucleotides | 1993 |
Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; GTP-Binding Proteins; Insulin; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Molecular Weight; Okadaic Acid; Phosphorylation; rab4 GTP-Binding Proteins; Serine | 1994 |
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Topics: 3T3 Cells; Adipocytes; Animals; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Receptor, Insulin; Serine; Signal Transduction; Threonine; Tyrosine | 1994 |
Functional correlation between the Ser/Thr-phosphorylation of band-3 and band-3-mediated transmembrane anion transport in human erythrocytes.
Topics: Anion Exchange Protein 1, Erythrocyte; Biological Transport; Erythrocytes; Ethers, Cyclic; Humans; Okadaic Acid; Oxalates; Phosphoprotein Phosphatases; Phosphorylation; Serine; Threonine | 1993 |
Protein tyrosine phosphatase 1B undergoes mitosis-specific phosphorylation on serine.
Topics: CDC2 Protein Kinase; Cell Cycle; Ethers, Cyclic; HeLa Cells; Humans; Mitosis; Okadaic Acid; Phosphorylation; Protein Tyrosine Phosphatases; Serine | 1993 |
Serine-1321-independent regulation of the mu 1 adult skeletal muscle Na+ channel by protein kinase C.
Topics: Adult; Alkaloids; Amino Acid Sequence; Base Sequence; Cell Line; Consensus Sequence; Conserved Sequence; DNA Primers; Enzyme Inhibitors; Ethers, Cyclic; Humans; Ion Channel Gating; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Multiple Sclerosis; Muscle, Skeletal; Mutagenesis, Site-Directed; Naphthalenes; Okadaic Acid; Phosphorylation; Polymerase Chain Reaction; Polyradiculoneuropathy; Protein Kinase C; Recombinant Proteins; Serine; Sodium Channels; Staurosporine; Transfection | 1995 |
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; Enzyme Inhibitors; Ethers, Cyclic; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Rats; Recombinant Proteins; Serine; Threonine; Transfection | 1996 |
Appearance of apparently ubiquitin-conjugated I kappa B-alpha during its phosphorylation-induced degradation in intact cells.
Topics: Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Humans; I-kappa B Proteins; Molecular Weight; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oligopeptides; Phosphorylation; Proteasome Endopeptidase Complex; Serine; Ubiquitins | 1995 |
Serine/threonine dephosphorylation may be involved in tyrosine phosphorylation: a new mode of signal transduction in platelets.
Topics: Blood Platelets; Humans; Okadaic Acid; Phosphorylation; Platelet Aggregation; Serine; Signal Transduction; Threonine; Tyrosine | 1996 |
Immunodetection of phosphorylation sites gives new insights into the mechanisms underlying phospholamban phosphorylation in the intact heart.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Isoproterenol; Male; Myocardium; Okadaic Acid; Phosphorylation; Rats; Rats, Wistar; Serine; Threonine | 1996 |
The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects.
Topics: Animals; Biological Transport; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Male; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Phosphatase 1; Rats; Receptor, Insulin; Serine; Staurosporine; Threonine; Tyrosine | 1996 |
Serine/threonine protein phosphatases and a protein phosphatase 1 inhibitor from Neurospora crassa.
Topics: Animals; Chromatography; Neurospora crassa; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Serine; Substrate Specificity; Threonine | 1996 |
Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells.
Topics: Animals; Antifungal Agents; Aphidicolin; Apoptosis; Cells, Cultured; Cricetinae; Cross Reactions; Enzyme Inhibitors; Griseofulvin; Humans; Keratins; Liver; Mice; Mice, Inbred BALB C; Mitosis; Okadaic Acid; Phosphorylation; Sequence Alignment; Serine; Stress, Physiological | 1997 |
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
Topics: Axons; Enzyme Inhibitors; Humans; Marine Toxins; Microtubules; Neurons; Okadaic Acid; Oxazoles; Serine; Threonine; Tumor Cells, Cultured | 1997 |
Induction of prostaglandin endoperoxide synthase-2 by serine-threonine phosphatase inhibition.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Isoenzymes; Mice; Mice, Inbred C57BL; NF-kappa B; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins; RNA, Messenger; Serine; Threonine; Transcription Factor RelB; Transcription Factors | 1997 |
Colchicine activates actin polymerization by microtubule depolymerization.
Topics: 3T3 Cells; Actins; Animals; Biopolymers; Cell Line; Colchicine; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mice; Microtubules; Okadaic Acid; Oxazoles; Phospholipase D; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rats; Serine; Threonine; Type C Phospholipases | 1997 |
PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Alanine; Animals; Cell Line; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Isoproterenol; Isoquinolines; Macromolecular Substances; Mutagenesis, Site-Directed; Okadaic Acid; Phosphorylation; Point Mutation; Rats; Recombinant Proteins; Rubidium; Serine; Sodium-Potassium-Exchanging ATPase; Spodoptera; Sulfonamides; Transfection | 1997 |
Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Affinity; DNA; DNA-Binding Proteins; Gene Expression Regulation; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Okadaic Acid; Phosphorylation; Protein Processing, Post-Translational; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Serine; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1997 |
Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A.
Topics: Animals; Brefeldin A; CHO Cells; Cricetinae; Cyclopentanes; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Golgi Apparatus; Hydroxycholesterols; Molecular Weight; Okadaic Acid; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Rabbits; Rats; Receptors, Steroid; Serine; Staurosporine | 1998 |
Water transport activity of the plasma membrane aquaporin PM28A is regulated by phosphorylation.
Topics: Animals; Aquaporins; Biological Transport; Cloning, Molecular; In Vitro Techniques; Membrane Proteins; Mutagenesis, Site-Directed; Okadaic Acid; Phosphorylation; Plant Proteins; Serine; Spinacia oleracea; Water; Xenopus | 1998 |
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.
Topics: Androstadienes; Binding Sites; Cell Nucleus; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Gene Products, tat; HeLa Cells; HIV Long Terminal Repeat; HIV-1; Humans; Jurkat Cells; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Sp1 Transcription Factor; tat Gene Products, Human Immunodeficiency Virus; Transcription, Genetic; Wortmannin | 1998 |
Phosphorylation of the catalyic alpha-subunit constitutes a triggering signal for Na+,K+-ATPase endocytosis.
Topics: Animals; Cell Membrane; Cells, Cultured; Cyclic AMP; Endocytosis; Endosomes; Genes, myc; Kidney Tubules, Proximal; Macromolecular Substances; Male; Mutagenesis, Site-Directed; Okadaic Acid; Opossums; Phosphorylation; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Serine; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Transfection | 1998 |
Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells.
Topics: Alanine; Antineoplastic Agents; Apoptosis; Depsipeptides; Humans; Mutagenesis, Site-Directed; Nocodazole; Okadaic Acid; Oligopeptides; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Serine; Tumor Cells, Cultured | 1998 |
Isoform specific phosphorylation of protein phosphatase 2C expressed in COS7 cells.
Topics: Animals; Casein Kinase II; COS Cells; Cyclosporine; Enzyme Inhibitors; Isoenzymes; Mice; Mutagenesis, Site-Directed; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Phosphatase 2C; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae Proteins; Serine | 1998 |
Activation of protein phosphatase 2A by cAMP-dependent protein kinase-catalyzed phosphorylation of the 74-kDa B'' (delta) regulatory subunit in vitro and identification of the phosphorylation sites.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Humans; Kinetics; Okadaic Acid; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Sequence Analysis; Serine; Substrate Specificity | 1998 |
Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcineurin; Calcineurin Inhibitors; DNA; DNA-Binding Proteins; Edetic Acid; Humans; Immune Sera; Immunosuppressive Agents; Molecular Sequence Data; Okadaic Acid; PC12 Cells; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Sequence Homology, Amino Acid; Serine; Substrate Specificity; Transcription Factors | 1998 |
Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A.
Topics: Animals; bcl-2-Associated X Protein; Bryostatins; Cell Line; Enzyme Activation; Interleukin-3; Kinetics; Lactones; Macrolides; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Serine; Transfection | 1998 |
The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation.
Topics: Alternative Splicing; Animals; Cell Nucleus; Cloning, Molecular; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Okadaic Acid; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Tumor Cells, Cultured | 1998 |
JAK1-dependent phosphorylation of insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation.
Topics: Animals; Humans; Insulin Receptor Substrate Proteins; Interferon Type I; Janus Kinase 1; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Recombinant Proteins; Serine; Substrate Specificity; Tumor Cells, Cultured | 1999 |
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes.
Topics: Anemia, Sickle Cell; Biological Transport; Carrier Proteins; Cell Size; Cytosol; Dehydration; Enzyme Inhibitors; Erythrocytes; Humans; Ionophores; K Cl- Cotransporters; Marine Toxins; Membrane Proteins; Nystatin; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Serine; Symporters; Threonine; Water-Electrolyte Balance | 1999 |
Inhibition of phosphatidylinositol 4,5-bisphosphate-stimulated phospholipase D2 activity by Ser/Thr phosphorylation.
Topics: Animals; COS Cells; Enzyme Inhibitors; HeLa Cells; Humans; Okadaic Acid; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Phosphorylation; Serine; Threonine; Transfection | 2000 |
A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro.
Topics: Amino Acid Sequence; Antigens, Viral; Cloning, Molecular; Cytoplasm; Enzyme Inhibitors; Escherichia coli; Heparin; Herpesvirus 4, Human; Immune Sera; Kinetics; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Sequence Homology, Amino Acid; Serine; Threonine; Viral Proteins | 2000 |
Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding.
Topics: Amino Acid Sequence; Animals; Cyclic AMP-Dependent Protein Kinases; Cyclin D; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Humans; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Kinase C; Proto-Oncogene Proteins; Serine; Spodoptera | 2000 |
Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Blood Platelets; Blood Proteins; Blotting, Western; Casein Kinase II; Enzyme Inhibitors; Humans; Kinetics; Molecular Sequence Data; Okadaic Acid; Phosphates; Phosphorylation; Polylysine; Precipitin Tests; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Serine; Threonine | 2000 |
Regulation of tyrosine hydroxylase activity and phosphorylation at Ser(19) and Ser(40) via activation of glutamate NMDA receptors in rat striatum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibody Specificity; Catalytic Domain; Caudate Nucleus; Colforsin; Dihydroxyphenylalanine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Okadaic Acid; Oxidopamine; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Sympatholytics; Tyrosine 3-Monooxygenase | 2000 |
Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo.
Topics: Animals; Benzazepines; Central Nervous System Stimulants; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; In Vitro Techniques; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microwaves; Neostriatum; Nerve Tissue Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Recombinant Fusion Proteins; Serine | 2000 |
Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that Do and Do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation.
Topics: Animals; Anisomycin; Arachidonic Acid; Calcimycin; Calcium; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ionophores; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NADPH Oxidases; Okadaic Acid; Phospholipase D; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Synthesis Inhibitors; Serine; Tetradecanoylphorbol Acetate; Time Factors; Zymosan | 2000 |
Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glioma; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Okadaic Acid; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Serine | 2000 |
Protein phosphatase 2A is associated with class C L-type calcium channels (Cav1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase.
Topics: Amino Acids; Animals; Brain; Calcium Channels, L-Type; Catalytic Domain; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Escherichia coli; Glutathione Transferase; Humans; Immunoblotting; Inhibitory Concentration 50; Ionophores; Microcystins; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Phosphatase 2; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Serine; Threonine | 2000 |
Phosphorylation of phospholamban at threonine-17 in the absence and presence of beta-adrenergic stimulation in neonatal rat cardiomyocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium Channel Agonists; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ionophores; Isoproterenol; Myocardium; Okadaic Acid; Phosphorylation; Rats; Rats, Wistar; Ryanodine; Sarcoplasmic Reticulum; Serine; Signal Transduction; Thapsigargin; Threonine; Time Factors | 2000 |
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection | 2001 |
Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation.
Topics: 3T3 Cells; Androstadienes; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Serine; Sirolimus; Threonine; Time Factors; Tyrosine; Vanadates; Wortmannin | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation | 2001 |
Site-specific phosphorylation of human p53 protein determined by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Chromatography, High Pressure Liquid; Chromatography, Liquid; Enzyme Inhibitors; Humans; Hydrolysis; Molecular Sequence Data; Okadaic Acid; Peptide Fragments; Phosphopeptides; Phosphorylation; Recombinant Proteins; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spodoptera; Trypsin; Tumor Suppressor Protein p53 | 2001 |
Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Communication; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Hepatocyte Growth Factor; Humans; Isoenzymes; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins c-met; Serine; Signal Transduction; src Homology Domains; Staurosporine; Threonine | 2001 |
Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Inhibitors; Heme; Humans; Kinetics; Liver; Mass Spectrometry; Mixed Function Oxygenases; Models, Molecular; Mutagenesis; Okadaic Acid; Peptide Fragments; Phenylalanine; Phosphopeptides; Phosphorylation; Protein Conformation; Protein Kinase C; Protein Structure, Secondary; Rats; Recombinant Proteins; Sequence Deletion; Serine; Staurosporine | 2001 |
Tumour necrosis factor-alpha activation of protein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Antineoplastic Agents; Cell Line; Cell Membrane; Cell Survival; Enzyme Activation; Enzyme Inhibitors; GTPase-Activating Proteins; Humans; Insulin-Like Growth Factor I; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Serine; Signal Transduction; Threonine; Transfection; Tumor Necrosis Factor-alpha | 2001 |
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbazoles; Dendrites; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Indoles; Long-Term Potentiation; Male; Neuronal Plasticity; Okadaic Acid; Phorbol Esters; Phosphorylation; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine | 2001 |
Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells.
Topics: Acetylation; Base Sequence; Breast Neoplasms; Chromatin; DNA Primers; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Okadaic Acid; Phosphorylation; Promoter Regions, Genetic; Serine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Dephosphorylation of Ser-259 regulates Raf-1 membrane association.
Topics: Animals; Blotting, Western; Cell Line; Cell Membrane; Cells, Cultured; COS Cells; Cytosol; Enzyme Activation; Humans; Models, Biological; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Phosphatase 2; Proto-Oncogene Proteins c-raf; Serine; Time Factors; Transfection | 2002 |
Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit.
Topics: Animals; Binding Sites; Blotting, Western; Cell Line; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Humans; Kinetics; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Potassium Channels; Potassium Channels, Calcium-Activated; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Serine; Threonine; Time Factors | 2002 |
Protein phosphatase 2A is involved in the regulation of protein kinase A signaling pathway during in vitro chondrogenesis.
Topics: Animals; Cartilage; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Chondrocytes; Chondrogenesis; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoquinolines; Limb Buds; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; Sulfonamides; Threonine; Time Factors | 2002 |
Regulation of novel protein kinase C epsilon by phosphorylation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; Amino Acid Sequence; Animals; Enzyme Inhibitors; Humans; Isoenzymes; Mice; Molecular Sequence Data; Okadaic Acid; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases; Sequence Alignment; Serine; Threonine | 2002 |
Phosphorylation of VP30 impairs ebola virus transcription.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; Cloning, Molecular; Dose-Response Relationship, Drug; Ebolavirus; Enzyme Inhibitors; HeLa Cells; Humans; Mutation; Nucleocapsid Proteins; Okadaic Acid; Phosphorylation; Plasmids; Protein Binding; Serine; Transcription, Genetic; Transcriptional Activation; Transfection; Vero Cells; Viral Proteins | 2002 |
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamine; Hepatocytes; Male; Marine Toxins; Multienzyme Complexes; Okadaic Acid; Oligomycins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Serine; Sirolimus | 2002 |
Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.
Topics: Animals; Cattle; Cell Line; COS Cells; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; Threonine; Transfection | 2002 |
Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Cricetinae; Dihydropyridines; Electrophysiology; Enzyme Inhibitors; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Serine; Threonine; Time Factors; Transfection | 2003 |
Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal.
Topics: Aldehydes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Down-Regulation; Enzyme Inhibitors; Feedback, Physiological; Humans; Jurkat Cells; Okadaic Acid; Oligopeptides; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; src-Family Kinases | 2003 |
Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.
Topics: Acetylcysteine; Angiotensin II; Animals; Aorta; Azoles; Blotting, Western; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Genes, Dominant; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Muscle, Smooth, Vascular; Okadaic Acid; Onium Compounds; Organoselenium Compounds; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Pyridines; Rats; Reactive Oxygen Species; Serine; Threonine; Time Factors | 2003 |
Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster.
Topics: Animals; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Gene Expression Regulation; Heat-Shock Response; Histones; Larva; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Proteins; RNA Polymerase II; Salivary Glands; Serine; Transcription Factors; Transcription, Genetic | 2003 |
Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage.
Topics: Catalytic Domain; Cell Line; DNA Damage; Gamma Rays; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Serine; Transcription, Genetic; Tumor Suppressor Protein p53 | 2004 |
Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons.
Topics: Animals; Cell Membrane; Cell Movement; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytoskeleton; Doublecortin Domain Proteins; Doublecortin Protein; Enzyme Inhibitors; Humans; Immunohistochemistry; Microtubule-Associated Proteins; Microtubules; Mutation; Nerve Tissue Proteins; Neurites; Neurons; Neuropeptides; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine | 2004 |
Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes.
Topics: Animals; beta Catenin; Blotting, Western; Cell Division; Cell Line; Chromans; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclin D1; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Genes, Reporter; Hepatocytes; Humans; Hypoglycemic Agents; Ligands; Liver; Luciferases; Mice; Mutation; Okadaic Acid; Plasmids; Receptors, Cytoplasmic and Nuclear; Serine; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone | 2004 |
Involvement of histone H3 (Ser10) phosphorylation in chromosome condensation without Cdc2 kinase and mitogen-activated protein kinase activation in pig oocytes.
Topics: Animals; CDC2 Protein Kinase; Chromosomes; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Histones; Marine Toxins; Models, Biological; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Serine; Sus scrofa | 2004 |
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation.
Topics: Adipocytes; Amino Acids; Animals; Anisomycin; Cell Line; Cytosol; Enzyme Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Serine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2004 |
IFN-gamma induces gp91phox expression in human monocytes via protein kinase C-dependent phosphorylation of PU.1.
Topics: Active Transport, Cell Nucleus; Cell Nucleus; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; Humans; Interferon-gamma; Isoenzymes; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Okadaic Acid; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins; Serine; Threonine; Trans-Activators | 2004 |
In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.
Topics: Amino Acids; Animals; Binding Sites; Biological Transport; Blotting, Western; Carrier Proteins; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Hepatocytes; Immunoprecipitation; Insulin; Intracellular Signaling Peptides and Proteins; Male; Okadaic Acid; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Recombinant Proteins; Serine; Sirolimus; Threonine; Time Factors; TOR Serine-Threonine Kinases | 2004 |
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Catalytic Domain; Cell Cycle Proteins; Cell Line; Comet Assay; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Gene Deletion; Gene Expression Regulation; Genes, Dominant; Green Fluorescent Proteins; Humans; Hydrazines; Microscopy, Confocal; Models, Biological; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Radiation, Ionizing; Serine; Signal Transduction; Tumor Suppressor Proteins; Two-Hybrid System Techniques | 2004 |
Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons.
Topics: Animals; Blotting, Western; Brain; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Immunoprecipitation; MAP Kinase Kinase 1; Marine Toxins; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Okadaic Acid; Oxazoles; Peptides; Phenylacetates; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Serine; Signal Transduction; Threonine; Time Factors; Up-Regulation | 2005 |
Phosphorylation of grb10 regulates its interaction with 14-3-3.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Androstadienes; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Membrane; COS Cells; Cytosol; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glutathione Transferase; GRB10 Adaptor Protein; HeLa Cells; Humans; Immunoprecipitation; Models, Biological; Mutation; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Biosynthesis; Proteins; Serine; Signal Transduction; Time Factors; Two-Hybrid System Techniques; Wortmannin | 2005 |
Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.
Topics: Antigens, CD; Cytokine Receptor gp130; Gene Expression; Humans; Interleukin-6; Leupeptins; Membrane Glycoproteins; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protease Inhibitors; Proteasome Inhibitors; RNA, Messenger; Serine; Tumor Cells, Cultured | 2005 |
PKB/AKT is involved in resumption of meiosis in mouse oocytes.
Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Centrosome; Chromones; Enzyme Activation; Female; In Vitro Techniques; Meiosis; Mice; Morpholines; Nuclear Envelope; Okadaic Acid; Oocytes; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Serine; Threonine | 2006 |
Disruption of the availability of amino acids induces a rapid reduction of serine phosphorylation of insulin receptor substrate-1 in vivo and in vitro.
Topics: Amino Acids; Animals; Cells, Cultured; Insulin Receptor Substrate Proteins; Male; Muscle, Skeletal; Okadaic Acid; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Rats, Wistar; Serine | 2005 |
Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.
Topics: Animals; Benzoquinones; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Mice; Myoblasts; Novobiocin; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction | 2005 |
Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: a cause of heterogeneity in mass and complications in function.
Topics: Acetylation; Alkaline Phosphatase; Animals; Aurora Kinases; Baculoviridae; Catalytic Domain; Cell Line; Escherichia coli; Focal Adhesion Kinase 2; Gas Chromatography-Mass Spectrometry; Gluconates; Histidine; Humans; Light; Molecular Weight; Okadaic Acid; Oligopeptides; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Recombinant Proteins; Scattering, Radiation; Serine; Spodoptera; Thrombin | 2005 |
Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspase 3; Caspase 9; Caspases; Cytochromes c; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Polyamines; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Small Interfering; Serine; Signal Transduction; Tumor Necrosis Factor-alpha | 2005 |
Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells.
Topics: Animals; Cell Line; Dopamine; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Okadaic Acid; PC12 Cells; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Serine; Tyrosine 3-Monooxygenase | 2005 |
Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.
Topics: Animals; Area Under Curve; Blotting, Western; Brain; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotics; Nuclear Proteins; Okadaic Acid; Pain; Phosphoprotein Phosphatases; Phosphorylation; Serine; Threonine; Time Factors | 2005 |
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Alkenes; Animals; B-Lymphocytes; Catalysis; Cell Line; Chromatography, Liquid; Cytoplasm; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Humans; I-kappa B Kinase; Immunoblotting; Immunoprecipitation; Inflammation; Jurkat Cells; Mice; Mice, Inbred C57BL; Mutation; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Pyrones; Sepharose; Serine; Signal Transduction; Spleen; Threonine; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Middle Aged; Okadaic Acid; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Time Factors; Tyrosine | 2005 |
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositols; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Phosphatase 1; Protein Phosphatase 2; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Pyrans; RNA, Small Interfering; Serine; Signal Transduction; Spiro Compounds; Subcellular Fractions; Threonine; Time Factors | 2005 |
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies.
Topics: Animals; Antibodies, Bispecific; Antibodies, Monoclonal; Brain; Brain Chemistry; Cell Line; Colonic Neoplasms; Cricetinae; Enzyme Inhibitors; Epitopes; HT29 Cells; Humans; Immunoblotting; Immunohistochemistry; Keratin-18; Keratin-8; Keratins; Kidney; Liver; Liver Diseases; Mice; Mutation; Okadaic Acid; Phosphorylation; Rabbits; Serine; Stomach Neoplasms; Transfection; Vaccination; Vanadates | 2006 |
Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Cell Adhesion; Cell Line; Colchicine; Cytochalasin D; Enzyme Inhibitors; Humans; Intermediate Filaments; Marine Toxins; Microtubules; Nocodazole; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Phosphatase 2; Pyrans; Serine; Signal Transduction; Spiro Compounds; Threonine; Tubulin Modulators | 2006 |
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Topics: Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Breast Neoplasms; Carcinogens; Cell Cycle Proteins; DNA Damage; DNA Repair; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Genes, BRCA1; HeLa Cells; Humans; Nuclear Proteins; Okadaic Acid; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Radiation, Ionizing; RNA, Small Interfering; Serine; Tumor Cells, Cultured; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Ubiquitin Thiolesterase | 2006 |
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.
Topics: Caco-2 Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; HT29 Cells; Humans; Hypotonic Solutions; Keratins; Microscopy, Confocal; Models, Biological; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 2; Serine; Stress, Physiological; Substrate Specificity; Xanthenes | 2006 |
Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons.
Topics: Animals; Calcium; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tyrosine | 2006 |
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.
Topics: Animals; Animals, Newborn; Calcineurin; Cells, Cultured; Cyclosporine; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Myocytes, Cardiac; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Serine; Threonine | 2006 |
Okadaic acid induces phosphorylation of p65NF-kappaB on serine 536 and activates NF-kappaB transcriptional activity in human osteoblastic MG63 cells.
Topics: Cell Line; Enzyme Inhibitors; Humans; Okadaic Acid; Osteoblasts; Phosphorylation; Promoter Regions, Genetic; Serine; Transcription Factor RelA; Transcription, Genetic | 2006 |
Functional interaction of Aurora-A and PP2A during mitosis.
Topics: Animals; Aurora Kinases; Catalytic Domain; Centrosome; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Humans; Mitosis; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Subunits; Serine | 2007 |
PP2A regulates HDAC4 nuclear import.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Caspases; Cell Line; Cell Nucleus; Electrophoresis, Gel, Two-Dimensional; Histone Deacetylases; Humans; Molecular Sequence Data; Mutant Proteins; Myogenic Regulatory Factors; Okadaic Acid; Phosphorylation; Protein Binding; Protein Interaction Mapping; Protein Phosphatase 2; Repressor Proteins; Serine | 2008 |
Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid.
Topics: Actins; Calcium; Cell Line; Cytoskeleton; Cytosol; Ethers, Cyclic; Humans; Membrane Potentials; Okadaic Acid; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Serine; Threonine | 2008 |
Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Calpain; Cysteine Proteinase Inhibitors; Cytosol; Escherichia coli; Escherichia coli Proteins; Glutathione Transferase; Half-Life; HeLa Cells; Humans; Leupeptins; Molecular Sequence Data; NIMA-Interacting Peptidylprolyl Isomerase; Okadaic Acid; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Binding; Recombinant Proteins; Serine; Sulfotransferases; Threonine; Transfection; Two-Hybrid System Techniques | 2009 |
Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Cell Line, Tumor; Cycloheximide; Enzyme Inhibitors; HCT116 Cells; HT29 Cells; Humans; Indoles; Keratinocytes; Mutation; Okadaic Acid; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; RNA, Messenger; RNA, Small Interfering; Serine; Sulfonamides; Time Factors; Transfection | 2009 |
Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 2; Cyclic AMP; DNA Damage; DNA-Binding Proteins; Doxorubicin; Gene Expression Regulation, Leukemic; Humans; Intracellular Space; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Phosphatase 1; Protein Phosphatase 2; Protein Phosphatase 2C; Protein Serine-Threonine Kinases; Serine; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2010 |
Ser123 is essential for the water channel activity of McPIP2;1 from Mesembryanthemum crystallinum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Animals; Aquaporins; Mesembryanthemum; Molecular Sequence Data; Mutagenesis, Site-Directed; Okadaic Acid; Oocytes; Permeability; Plant Proteins; Serine; Tetradecanoylphorbol Acetate; Water; Xenopus laevis | 2010 |
Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.
Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Lithium Chloride; Neurons; Okadaic Acid; Oximes; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 2; Rats; Serine | 2010 |
Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP Response Element-Binding Protein; Cyclosporine; Diabetes Mellitus; Enzyme Inhibitors; Insulin Resistance; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Mutagenesis, Site-Directed; Okadaic Acid; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Trans-Activators; Transcription Factors | 2010 |
Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoprecipitation; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Pyrans; Serine; Signal Transduction; Sphingosine; Spiro Compounds | 2011 |
Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arrestins; beta-Arrestins; Biocatalysis; Cell Membrane; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Receptors, Somatostatin; Serine; Signal Transduction; Time Factors | 2011 |
Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.
Topics: Analysis of Variance; Animals; Boronic Acids; Bortezomib; Cells, Cultured; Dendrites; Disks Large Homolog 4 Protein; Drosophila Proteins; Embryo, Mammalian; Enzyme Inhibitors; Female; Fragile X Mental Retardation Protein; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Leupeptins; Male; Membrane Proteins; Methoxyhydroxyphenylglycol; Mutation; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger; Serine; Signal Transduction; Synapses; Transfection; Ubiquitination | 2012 |
Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137.
Topics: Animals; Blotting, Western; Dicarboxylic Acids; Dose-Response Relationship, Drug; HEK293 Cells; HeLa Cells; Humans; Immunohistochemistry; Mice; NIH 3T3 Cells; Okadaic Acid; Phosphorylation; Profilins; Protein Binding; Protein Phosphatase 1; Protein Phosphatase 2; RNA Interference; Serine | 2012 |
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cytoskeletal Proteins; Dendrites; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fragile X Mental Retardation Protein; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Humans; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Nerve Tissue Proteins; Neurons; Okadaic Acid; Patch-Clamp Techniques; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Serine; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Transfection | 2012 |
Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
Topics: Acetophenones; Amino Acid Substitution; Animals; Aorta; Argininosuccinate Synthase; Benzopyrans; Bradykinin; Calcium; Calcium Signaling; Cattle; Cells, Cultured; Endothelial Cells; Enzyme Activation; Gene Knockdown Techniques; Indoles; Isoenzymes; Maleimides; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Synthase Type III; Okadaic Acid; Phosphorylation; Protein Kinase C-alpha; Protein Phosphatase 1; Protein Phosphatase 2; Protein Processing, Post-Translational; RNA Interference; Serine | 2012 |
Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole.
Topics: Blotting, Western; Caco-2 Cells; Chelating Agents; Cytochrome P-450 CYP1A1; Egtazic Acid; Enzyme Inhibitors; Hep G2 Cells; Humans; MCF-7 Cells; Models, Genetic; Okadaic Acid; Omeprazole; Phosphorylation; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Protein Binding; Protein Phosphatase 2; Proton Pump Inhibitors; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; Sp1 Transcription Factor; Transcriptional Activation | 2014 |
Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Deoxycytidine Kinase; HEK293 Cells; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Protein Processing, Post-Translational; Serine | 2014 |
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Topics: Animals; Binding Sites; Blotting, Western; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Hippocampus; Humans; Male; Marine Toxins; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Protein Phosphatase 2; Protein Subunits; Receptors, AMPA; Serine; Threonine | 2014 |
Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Topics: Animals; bcl-X Protein; Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Cyclin D1; Glioma; HEK293 Cells; Humans; Okadaic Acid; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Serine; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transplantation, Heterologous | 2014 |
Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.
Topics: Binding Sites; Burkitt Lymphoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Marine Toxins; Myeloid Cell Leukemia Sequence 1 Protein; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 2; Proteolysis; Serine; Tetradecanoylphorbol Acetate; Threonine | 2014 |
Dexmedetomidine directly increases tau phosphorylation.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Brain; Cells, Cultured; Cerebral Cortex; Dexmedetomidine; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Male; Neurons; Okadaic Acid; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; tau Proteins; Threonine; Time Factors | 2015 |
Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle.
Topics: Animals; Benzophenanthridines; Cell Line; GTPase-Activating Proteins; Immunoblotting; Immunoprecipitation; Isoquinolines; Male; Muscle, Skeletal; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Wistar; Rats, Zucker; RNA, Small Interfering; Serine; Tacrolimus | 2016 |
Vimentin dephosphorylation at ser-56 is regulated by type 1 protein phosphatase in smooth muscle.
Topics: Actins; Animals; Crk-Associated Substrate Protein; Dose-Response Relationship, Drug; Female; Male; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Okadaic Acid; Phosphorylation; Protein Binding; Protein Phosphatase 1; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-abl; RNA Interference; Serine; Time Factors; Tissue Culture Techniques; Trachea; Transfection; Vimentin | 2016 |
Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion.
Topics: Alternative Splicing; DNA-Binding Proteins; Exons; HEK293 Cells; HeLa Cells; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Serine; tau Proteins; Up-Regulation | 2018 |
Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics.
Topics: Animals; Cell Movement; Cell Polarity; CHO Cells; Cricetulus; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; Focal Adhesions; Models, Biological; Okadaic Acid; p21-Activated Kinases; Paxillin; Phosphorylation; rac GTP-Binding Proteins; rho GTP-Binding Proteins; Serine; Signal Transduction | 2018 |