serine has been researched along with nutlin-3a in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carvajal, D; Heimbrook, DC; Thompson, T; Tovar, C; Vassilev, LT; Vu, BT; Wahl, GM; Xu, Q; Yang, H | 1 |
| Chang, NS; Doherty, J; Ensign, A; Hong, Q; Hsu, LJ; Schultz, L | 1 |
| Cox, ML; Meek, DW | 1 |
| Ichwan, SJ; Ikeda, MA; Iseki, S; Ma, T; Ohtani, K; Otsu, M; Yamada, S | 1 |
| Cox, M; Loughery, J; Meek, DW; Smith, LM | 1 |
| Gu, W; Jiang, L; Ou, Y; Wang, SJ; Zheng, B | 1 |
| Gdowicz-Kłosok, A; Krześniak, M; Rusin, M; Ścieglińska, D; Zajkowicz, A | 1 |
| Aiken, J; Birot, O; Ciccone, J; Drouin, G; Grenier, G; Gustafsson, T; Haas, T; Olfert, IM; Roudier, E; Stromberg, A; Vojnovic, J | 1 |
| Gdowicz-Kłosok, A; Krześniak, M; Rusin, M; Zajkowicz, A; Łasut, B | 1 |
9 other study(ies) available for serine and nutlin-3a
| Article | Year |
|---|---|
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis.
Topics: Annexin A5; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Coloring Agents; DNA; Dose-Response Relationship, Drug; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Etoposide; Humans; Imidazoles; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Transcriptional Activation; Tumor Suppressor Protein p53 | 2004 |
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
Topics: Active Transport, Cell Nucleus; Animals; Anisomycin; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Etoposide; Fibroblasts; Genes, Dominant; Humans; Hypoxia; Imidazoles; Immunoprecipitation; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Oxidoreductases; Phosphorylation; Piperazines; Proteasome Endopeptidase Complex; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Staurosporine; Time Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; U937 Cells; Ultraviolet Rays; WW Domain-Containing Oxidoreductase | 2005 |
Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli.
Topics: ADP-Ribosylation Factors; Casein Kinase II; Cell Line; Enzyme Inhibitors; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-mdm2; RNA, Small Interfering; Serine; Signal Transduction; Tumor Suppressor Protein p53; Ultraviolet Rays | 2010 |
Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Furans; Genes, p53; Humans; Imidazoles; Phosphorylation; Piperazines; Poly(ADP-ribose) Polymerases; Serine; Transduction, Genetic; Tumor Suppressor Protein p53 | 2012 |
Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.
Topics: Cell Line, Tumor; Chromatin; DNA Damage; Etoposide; Humans; Imidazoles; Mutation; Phosphorylation; Piperazines; Promoter Regions, Genetic; Serine; Transcriptional Activation; Tumor Suppressor Protein p53 | 2014 |
p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.
Topics: Activating Transcription Factor 4; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Imidazoles; Melanocytes; Molecular Sequence Data; Phosphoglycerate Dehydrogenase; Piperazines; RNA, Small Interfering; Serine; Signal Transduction; Tumor Suppressor Protein p53 | 2015 |
Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.
Topics: Cell Line, Tumor; Dactinomycin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-mdm2; Serine; Tumor Suppressor Protein p53 | 2015 |
Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression.
Topics: Animals; Cell Movement; Cells, Cultured; Endothelial Cells; Female; Forkhead Transcription Factors; Gene Expression; Humans; Imidazoles; Male; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphorylation; Physical Conditioning, Animal; Piperazines; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Serine; Vascular Endothelial Growth Factor A | 2016 |
PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a.
Topics: Amino Acid Sequence; Apoptosis; bcl-Associated Death Protein; Camptothecin; Cell Line, Tumor; Dactinomycin; Drug Synergism; Gene Knockdown Techniques; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Phosphorylation; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Long Noncoding; RNA, Messenger; Serine; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53; Up-Regulation | 2018 |