serine has been researched along with n-methylaspartate in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (6.73) | 18.7374 |
| 1990's | 32 (30.77) | 18.2507 |
| 2000's | 39 (37.50) | 29.6817 |
| 2010's | 18 (17.31) | 24.3611 |
| 2020's | 8 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Li, M; Ryan, R; Wood, PL | 1 |
| Lazarewicz, JW; Puka, M; Salińska, E | 1 |
| Wayman, CP; Wilson, JF | 1 |
| Oles, RJ; Singh, L; Tricklebank, MD | 1 |
| Oles, RJ; Singh, L; Vass, CA; Woodruff, GN | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Cler, JA; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A | 1 |
| Salt, TE | 1 |
| Costa, E; Fadda, E; Lazarewicz, JW; Mazzetta, J; Wroblewski, JT | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Daly, MP; Demediuk, P; Faden, AI | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Botscheller, ML; DeKosky, ST; Marion, DW; Palmer, AM; Styren, SD; Swedlow, PE | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Raiteri, M; Vallebuona, F | 1 |
| Bowlby, MR | 1 |
| Lehmann, JC; Procureur, D; Wood, PL | 1 |
| Harmsworth, WL; Sofia, RD; White, HS; Wolf, HH | 1 |
| Woodward, JJ | 2 |
| Abe, K; Chu, PJ; Saito, H; Samejima, K; Shirahata, A | 1 |
| Jhamandas, JH; Zidichouski, JA | 1 |
| Cortinovis, S; Lucca, A; Lucini, V | 1 |
| Chouinard, ML; Gaitan, D; Wood, PL | 1 |
| Gebhart, GF; Kolhekar, R | 1 |
| Jane, DE; Thomas, NK; Tse, HW; Watkins, JC | 1 |
| Bisaglia, M; Fedele, E; Raiteri, M | 1 |
| Chaplan, SR; Partridge, BJ; Sakamoto, E; Yaksh, TL | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Gemignani, A; Paudice, P; Raiteri, M | 1 |
| D'Souza, DC; Krystal, JH | 1 |
| Allgeier, H; Angst, C; Benke, D; Heckendorn, R; Honer, M; Mohler, H; Pozza, MF | 1 |
| Blackshaw, S; Snyder, SH; Wolosker, H | 1 |
| Bennett, MV; Wang, AP; Zhang, L; Zheng, X; Zukin, RS | 1 |
| Fisone, G; Goiny, M; Goldstein, M; Haycock, J; Herrera-Marschitz, M; Hökfelt, T; Lindgren, N; Lindskog, M; Xu, ZQ | 1 |
| Hashimoto, A; Kanda, J; Oka, T | 1 |
| Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M | 1 |
| Bibb, JA; Czernik, AJ; Greengard, P; Hisanaga , S; Horiuchi, A; Lan, M; Nairn, AC; Nishi, A; O'Callaghan, JP; Saito, T; Snyder, GL; Ule, J | 1 |
| Jancarik, J; Kim, R; Kim, SH; Wang, W; Yokota, H | 1 |
| Mothet, JP | 1 |
| Shu, YS; Zhang, YH; Zhao, ZQ | 1 |
| Awobuluyi, M; Chatterton, JE; Cui, J; Lipton, SA; Nakanishi, N; Premkumar, LS; Sevarino, KA; Shin, Y; Takahashi, H; Talantova, M; Tong, G; Tu, S; Zhang, D | 1 |
| Chen, L; Muhlhauser, M; Yang, CR | 1 |
| Kawasaki, K; Ogawa, S | 1 |
| Choi, JI; Jeong, SW; Yoon, MH | 1 |
| Kennedy, MB; Manzerra, P; Oh, JS | 1 |
| Gemignani, A; Longordo, F; Paudice, P; Raiteri, M | 1 |
| Akaike, A; Katsuki, H; Kume, T; Nonaka, M; Shirakawa, H | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Chan, HH; Chan, LN; Chang, DC; Han, Y; Lee, NT; Li, M; Li, W; Pi, R; Pu, Y; Sucher, NJ | 1 |
| Baptista, V; Varanda, WA | 1 |
| Guo, JD; Wang, H; Zhang, YQ; Zhao, ZQ | 1 |
| Kartvelishvily, E; Shleper, M; Wolosker, H | 1 |
| Derkach, VA; Guire, ES; Oh, MC; Soderling, TR | 1 |
| Cao, H; Guo, JD; Ji, RR; Ren, WH; Sha, H; Wang, H; Wang, PF; Zhang, YQ; Zhao, ZQ | 1 |
| Hashimoto, K; Hayashi, Y; Ishibashi, H; Nakanishi, H | 1 |
| Dell'Acqua, ML; Gibson, ES; Smith, KE | 1 |
| Dash, PK; Kobori, N; Moore, AN | 1 |
| Solís, JM; Suárez, LM | 1 |
| Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C; Tochikawa, Y | 1 |
| Di Luca, M; Gardoni, F; Marcello, E; Mauceri, D | 1 |
| Cattabeni, F; Di Luca, M; Gardoni, F; Polli, F | 1 |
| Akaike, A; Fujimoto, S; Katsuki, H; Kume, T; Watanabe, Y | 1 |
| Aiso, S; Chiba, T; Matsuoka, M; Nishimoto, I; Okamoto, K; Sasabe, J; Yamada, M | 1 |
| Cho, K; Futai, K; Hayashi, Y; Jo, J; Kim, MJ; Sheng, M | 1 |
| Aperia, A; Axehult, G; Bondar, A; Brismar, H; Gunnarson, E; Krieger, P; Song, Y; Zelenin, S; Zelenina, M | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kim, KW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Huganir, RL; Lavezzari, G; McBain, CJ; Pelkey, KA; Roche, KW; Roche, PA; Suh, YH | 1 |
| Harai, T; Hashimoto, K; Inoue, R; Mori, H | 1 |
| Kass-Simon, G; Kay, JC | 1 |
| Hu, XD; Liu, XH; Xie, QJ; Yang, HB; Yang, X | 1 |
| Hinoi, E; Hirai, T; Iemata, M; Takahata, Y; Takarada, T; Uno, K; Yamamoto, T; Yoneda, Y | 1 |
| Chen, BS; Roche, KW | 1 |
| Benedetti, B; Boresch, M; Kettenmann, H; Müller, J; Nolte, C; Pivneva, T; Reyes-Haro, D; Scheller, A | 1 |
| Jeong, HJ; Vandenberg, RJ; Vaughan, CW | 1 |
| Azuma, N; Esaki, K; Furuya, S; Hamase, K; Hirabayashi, Y; Itohara, S; Kinoshita, MO; Machida, T; Messing, A; Miyoshi, Y; Sayano, T; Tomonaga, S; Wada, A; Watanabe, M; Yang, JH; Yoshida, K; Zaitsu, K | 1 |
| Grant, SG; Indersmitten, T; Komiyama, NH; Moody, TD; O'Dell, TJ; Watabe, AM | 1 |
| Bateup, HS; Denefrio, CL; Sabatini, BL; Saulnier, JL; Takasaki, KT | 1 |
| Anderson, CM; Anderson, HD; Knox, JD; LeMaistre, JL; Lu, L; Sanders, SA; Stobart, MJ | 1 |
| Cameron, A; Gong, Z; Harrington, J; Lockridge, A; Newland, B; Romero, G; Yuan, LL | 1 |
| Bettio, LE; Budni, J; Colla, AR; Cunha, MP; Oliveira, Á; Pazini, FL; Rodrigues, AL | 1 |
| Kaster, MP; Machado, DG; Rodrigues, AL; Santos, AR | 1 |
| Chi, S; Park, D; Park, E | 1 |
| Chick, WS; Dell'Acqua, ML; Freund, RK; Gibson, ES; Gorski, JA; Lam, P; Sanderson, JL | 1 |
| Gao, M; Jiang, E; Weng, HR; Yan, X | 1 |
| Rozsa, E; Vigh, J | 1 |
| Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A | 1 |
| Chen, ZQ; Jiang, ZL; Li, X; Sun, L; Xu, LH; Yang, Y; Zhang, YF; Zhang, YY | 1 |
| Balu, DT; Coyle, JT; Ishiwata, S; Nishikawa, T; Umino, A | 1 |
| Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
| Alcon, C; Altafaj, X; Armstrong, J; Bayés, À; Chu-Van, E; Ciruela, F; Colsch, B; Fernández-Dueñas, V; García-Cazorla, À; García-Díaz, R; Gasull, X; Gómez de Salazar, M; Gratacòs-Batlle, E; Grau, C; Locubiche, S; López-Sala, A; Olivella, M; Ramos-Vicente, D; Santos-Gómez, A; Sindreu, C; Soto, D | 1 |
| Ma, J; Si, P; Sun, X; Wu, J; Yan, LJ; Yang, X; Yin, L; Zhang, C; Zhang, Y | 1 |
| Borczyk, M; Nowacka, A; Radwanska, K; Salamian, A; Wójtowicz, T; Włodarczyk, J | 1 |
| Alejandro, EU; Gustafson, E; Lockridge, A; Miller, RF; Wong, A | 1 |
| Aziz, O; Bell, JA; Bhat, S; Bloomfield, DE; Bochevarov, A; Chapman, RSL; Chauhan, A; Dahlgren, MK; Day, T; Dechaux, EA; Ellard, JM; Fraser, IJ; Frye, L; Gallati, C; Gordon, JA; Hirst, KL; Houang, E; Janssens, HB; Jensen, K; Jones, DR; Ladha, S; Lewis, JH; McRobb, FM; Osborne, JD; Palomero, MA; Sephton, M; Sharpe, A; Skene, RJ; Svensson, M; Tang, H; Tardia, P; Taylor, A; Tierney, JP; Valentine, A; Waddell, RD | 1 |
| Barger, SW; Wu, S; Zhang, H; Zhou, J | 1 |
| Agarwal, D; Croset, V; Meschi, E; Otto, N; Park, A; Sims, D; Treiber, CD; Waddell, S | 1 |
| Carlson, M; Choo, TH; De Baun, HM; Dias, E; Gangwisch, J; Girgis, RR; Iosifescu, DV; Kantrowitz, JT; Kegeles, LS; Mayer, MR; Medalia, A; Saperstein, AM; Sehatpour, P; Shope, C; Sobeih, T; Wall, MM | 1 |
| Bassi, MS; Buttari, F; Carta, M; Centonze, D; De Rosa, A; Di Maio, A; Errico, F; Gilio, L; Morelli, M; Nuzzo, T; Sasabe, J; Serra, M; Sulzer, D; Usiello, A | 1 |
2 review(s) available for serine and n-methylaspartate
| Article | Year |
|---|---|
Physiological relevance of endogenous free D-serine in the mammalian brain: are scientists on a royal road for the treatment of glutamatergic-related brain disorders?
Topics: Animals; Astrocytes; Brain Chemistry; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 2001 |
Serine Racemase Expression Differentiates Aging from Alzheimer's Brain.
Topics: Aging; Alzheimer Disease; Brain; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine | 2022 |
1 trial(s) available for serine and n-methylaspartate
| Article | Year |
|---|---|
Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine.
Topics: Antipsychotic Agents; Double-Blind Method; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2023 |
101 other study(ies) available for serine and n-methylaspartate
| Article | Year |
|---|---|
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
NMDA-, but not kainate- or quisqualate-dependent increases in cerebellar cGMP are dependent upon monoaminergic innervation.
Topics: Animals; Cerebellum; Cyclic GMP; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Glycine enhances extracellular 45Ca2+ response to NMDA application investigated with microdialysis of rabbit hippocampus in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Dialysis; Drug Synergism; Extracellular Space; Glycine; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Characteristics of NMDA receptors that stimulate release of hypothalamic alpha-MSH.
Topics: alpha-MSH; Animals; Hypothalamus; In Vitro Techniques; Ketamine; Kinetics; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Piperazines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1990 |
A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Spermidine | 1991 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
6,7-Dinitroquinoxaline-2,3-dione and 6-nitro,7-cyanoquinoxaline-2,3-dione antagonize responses mediated by N-methyl-D-aspartate and NMDA-associated glycine recognition sites in vivo: measurements of cerebellar cyclic-GMP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebellum; Cyclic AMP; Glycine; Harmaline; Kinetics; Male; Mice; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Serine | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Conductivity; Female; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Synapses; Tetrodotoxin | 1990 |
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine | 1989 |
Modulation of NMDA receptor-mediated responses by glycine and D-serine in the rat thalamus in vivo.
Topics: Action Potentials; Animals; Aspartic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine; Thalamus | 1989 |
Glycine and D-serine act as positive modulators of signal transduction at N-methyl-D-aspartate sensitive glutamate receptors in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Glycine; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Signal Transduction; Strychnine | 1989 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Laminectomy; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Serine; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine | 1989 |
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine; Strychnine | 1988 |
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glycine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Synaptic Membranes | 1988 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Male; Microdialysis; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Serine | 1993 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Extracellular Space; Guanylate Cyclase; Hippocampus; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Serine; Vasodilator Agents | 1995 |
Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Felbamate modulates the strychnine-insensitive glycine receptor.
Topics: Animals; Anticonvulsants; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Felbamate; Glycine; Mice; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Receptors, Glycine; Serine; Strychnine | 1995 |
A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serine | 1994 |
The effects of thiol reduction and oxidation on the inhibition of NMDA-stimulated neurotransmitter release by ethanol.
Topics: Animals; Dithionitrobenzoic Acid; Dithiothreitol; Ethanol; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Serine; Sulfhydryl Compounds | 1994 |
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
Topics: Animals; Cyclohexylamines; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Putrescine; Seizures; Serine; Spermidine; Spermine | 1994 |
Electrophysiological characterization of excitatory amino acid responses in rat lateral parabrachial neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Evoked Potentials; In Vitro Techniques; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Neurons; Pons; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Serine; Time Factors | 1993 |
Serine and glycine metabolism in schizophrenic patients.
Topics: Adult; Glycine; Glycine Hydroxymethyltransferase; Humans; Male; N-Methylaspartate; Schizophrenia; Serine | 1993 |
Presence of the N-methyl-D-aspartate-associated glycine receptor agonist, D-serine, in human temporal cortex: comparison of normal, Parkinson, and Alzheimer tissues.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Gas Chromatography-Mass Spectrometry; Humans; Middle Aged; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Reference Values; Serine; Temporal Lobe | 1993 |
Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Colon; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Serine; Skin; Spinal Cord; Synaptic Transmission | 1996 |
alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Motor Neurons; N-Methylaspartate; Rats; Receptors, Metabotropic Glutamate; Serine | 1996 |
D-serine modulates the NMDA receptor/nitric oxide/cGMP pathway in the rat cerebellum during in vivo microdialysis.
Topics: Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1997 |
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glutamate; Serine; Stereoisomerism; Substance P | 1998 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Evidence for functional native NMDA receptors activated by glycine or D-serine alone in the absence of glutamatergic coagonist.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Dose-Response Relationship, Drug; Drug Synergism; Glutamic Acid; Glycine; Male; N-Methylaspartate; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Somatostatin; Stereoisomerism; Synaptosomes | 1998 |
D-serine and the therapeutic challenge posed by the N-methyl-D-aspartate antagonist model of schizophrenia.
Topics: Glycine; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 1998 |
[3H]CGP 61594, the first photoaffinity ligand for the glycine site of NMDA receptors.
Topics: Affinity Labels; Animals; Azides; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Agonists; Glycine; Hippocampus; In Vitro Techniques; Kinetics; Ligands; Male; N-Methylaspartate; Neocortex; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Tritium | 1999 |
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.
Topics: Amino Acid Sequence; Animals; Astrocytes; Base Sequence; Cell Line; DNA Primers; Humans; Immunohistochemistry; Molecular Sequence Data; N-Methylaspartate; Racemases and Epimerases; Rats; Sequence Homology, Amino Acid; Serine | 1999 |
Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Ion Channels; Long-Term Potentiation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Peptide Fragments; Phosphorylation; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Xenopus | 1999 |
Regulation of tyrosine hydroxylase activity and phosphorylation at Ser(19) and Ser(40) via activation of glutamate NMDA receptors in rat striatum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibody Specificity; Catalytic Domain; Caudate Nucleus; Colforsin; Dihydroxyphenylalanine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Okadaic Acid; Oxidopamine; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Sympatholytics; Tyrosine 3-Monooxygenase | 2000 |
Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Perfusion; Rats; Rats, Wistar; Serine; Time Factors; Veratridine | 2000 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc | 2001 |
Phosphorylation of protein phosphatase inhibitor-1 by Cdk5.
Topics: Animals; Binding Sites; Brain; Calcineurin; Carrier Proteins; CDC2 Protein Kinase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; N-Methylaspartate; Phosphoprotein Phosphatases; Phosphorylation; Proline; Protein Phosphatase 1; Rabbits; Rats; Recombinant Proteins; RNA-Binding Proteins; Serine; Time Factors | 2001 |
Crystal structure of phosphoserine phosphatase from Methanococcus jannaschii, a hyperthermophile, at 1.8 A resolution.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Humans; Magnesium; Methanococcus; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Phosphates; Phosphoric Monoester Hydrolases; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine | 2001 |
Substance P potentiates thermal hyperalgesia induced by intrathecal administration of D-serine in rats.
Topics: Animals; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; N-Methylaspartate; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Serine; Substance P | 2001 |
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.
Topics: Animals; Calcium; Cations, Divalent; Central Nervous System; Cloning, Molecular; Electrophysiology; Glutamic Acid; Glycine; Immunohistochemistry; In Situ Hybridization; Ion Transport; Magnesium; Molecular Sequence Data; N-Methylaspartate; Neurons; Oocytes; Protein Subunits; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology; Serine; Substrate Specificity; Xenopus laevis | 2002 |
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.
Topics: Amino Acid Transport Systems, Neutral; Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Plasma Membrane Transport Proteins; Iontophoresis; Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine | 2003 |
[The role of glycine binding site in NMDA receptor--interactions between NMDA and D-serine in artificial anoxia/agycemia rat hippocampus].
Topics: Animals; Binding Sites; Glycine; Hippocampus; Hypoxia; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2003 |
Spinal gabapentin and antinociception: mechanisms of action.
Topics: Acetates; Adrenergic alpha-Antagonists; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amines; Analgesics; Animals; Atropine; Cyclohexanecarboxylic Acids; Dihydroergocristine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Leucine; Male; Mecamylamine; Muscarinic Antagonists; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nicotinic Antagonists; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Thapsigargin; Triazoles | 2003 |
Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II.
Topics: Animals; Apoptosis; Binding Sites; Blotting, Western; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, High Pressure Liquid; Cytoplasm; Dose-Response Relationship, Drug; Glutathione Transferase; GTPase-Activating Proteins; Insecta; Mass Spectrometry; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Phosphopeptides; Phosphorylation; Rats; Recombinant Fusion Proteins; Serine; Signal Transduction; Time Factors; Trypsin | 2004 |
External pH changes affect NMDA-evoked and spontaneous release of cholecystokinin, somatostatin and noradrenaline from rat cerebrocortical nerve endings.
Topics: Animals; Botulinum Toxins; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cholecystokinin; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; N-Methylaspartate; Nerve Endings; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Norepinephrine; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Serine; Somatostatin; Synaptosomes | 2004 |
Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices.
Topics: Animals; Cell Death; Cerebral Cortex; Excitatory Amino Acid Agonists; Female; In Vitro Techniques; Ischemia; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Serine | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Cell Count; Cell Survival; Cells, Cultured; Cerebellum; Chromatin; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Humans; Membrane Potentials; Microscopy, Confocal; Minocycline; N-Methylaspartate; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factors | 2004 |
Glycine binding site of the synaptic NMDA receptor in subpostremal NTS neurons.
Topics: Aminoquinolines; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Solitary Nucleus; Strychnine; Synapses | 2005 |
Alterations of membrane properties and effects of D-serine on NMDA-induced current in rat anterior cingulate cortex neurons after monoarthritis.
Topics: Action Potentials; Animals; Arthralgia; Arthritis, Experimental; Cell Membrane; Differential Threshold; Electric Conductivity; Gyrus Cinguli; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2005 |
D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.
Topics: Animals; Excitatory Amino Acid Agonists; Hippocampus; N-Methylaspartate; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2005 |
Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation.
Topics: Animals; Binding Sites; Biotinylation; Blotting, Western; Colforsin; Electrophysiology; Hippocampus; Long-Term Potentiation; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Phosphorylation; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Rolipram; Serine; Synaptic Transmission; Time Factors | 2006 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission | 2006 |
Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors.
Topics: Animals; Animals, Newborn; Cell Communication; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Microglia; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 2006 |
cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bacterial Proteins; Blotting, Western; Calcineurin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Dendrites; Disks Large Homolog 4 Protein; Drug Interactions; Enzyme Activation; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Synaptic Depression; Luminescent Proteins; Male; Membrane Proteins; Mutagenesis; N-Methylaspartate; Neurons; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Time Factors; Transfection; Valine | 2006 |
GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activity.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cells, Cultured; Culture Media, Serum-Free; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation, Neoplastic; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Mesencephalon; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Rats; Serine; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine | 2006 |
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine | 2006 |
Dual role of CaMKII-dependent SAP97 phosphorylation in mediating trafficking and insertion of NMDA receptor subunit NR2A.
Topics: Adaptor Proteins, Signal Transducing; Animals; Caffeine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cricetinae; Cricetulus; Drug Interactions; Embryo, Mammalian; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Hippocampus; Immunoprecipitation; In Vitro Techniques; Membrane Proteins; N-Methylaspartate; Neurons; Phosphodiesterase Inhibitors; Phosphorylation; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Transfection | 2007 |
Calcium-calmodulin-dependent protein kinase II phosphorylation modulates PSD-95 binding to NMDA receptors.
Topics: Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chlorocebus aethiops; Disks Large Homolog 4 Protein; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Immunoprecipitation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mutagenesis; N-Methylaspartate; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Sulfonamides; Transfection | 2006 |
Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures.
Topics: Animals; Animals, Newborn; Cell Death; Cell Survival; Cerebral Cortex; Excitatory Amino Acid Agonists; Glucose; Glycine; In Vitro Techniques; Ischemia; N-Methylaspartate; Oxygen; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 2007 |
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Motor Neurons; Mutation; N-Methylaspartate; Neuroglia; p38 Mitogen-Activated Protein Kinases; Racemases and Epimerases; Serine; Spinal Cord; Superoxide Dismutase; Up-Regulation | 2007 |
Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95.
Topics: Animals; Animals, Newborn; Cells, Cultured; Disks Large Homolog 4 Protein; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hippocampus; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Long-Term Synaptic Depression; Membrane Proteins; Mutation; N-Methylaspartate; Organ Culture Techniques; Phosphorylation; rac1 GTP-Binding Protein; Rats; Receptors, AMPA; Serine; Signal Transduction; Synaptic Membranes; Synaptic Transmission | 2007 |
Identification of a molecular target for glutamate regulation of astrocyte water permeability.
Topics: Animals; Animals, Newborn; Aquaporin 4; Astrocytes; Benzylamines; Calcium; Cell Line, Transformed; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Methoxyhydroxyphenylglycol; N-Methylaspartate; Permeability; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Serine; Sulfonamides; Transfection; Water | 2008 |
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Pain; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Signal Processing, Computer-Assisted; Signal Transduction; Spinal Cord; Time Factors | 2008 |
Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acids; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Mutation; N-Methylaspartate; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Serine; Transfection | 2008 |
NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.
Topics: Amyloid beta-Peptides; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurotoxicity Syndromes; Neurotoxins; Peptide Fragments; Racemases and Epimerases; Serine | 2008 |
Glutamatergic transmission in hydra: NMDA/D-serine affects the electrical activity of the body and tentacles of Hydra vulgaris (Cnidaria, Hydrozoa).
Topics: Analysis of Variance; Animals; Electrophysiology; Extremities; Glutamic Acid; Hydra; Motor Activity; N-Methylaspartate; Serine; Synaptic Transmission | 2009 |
Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Inflammation; Isoquinolines; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Pain Measurement; Posterior Horn Cells; Protein Kinase Inhibitors; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord; Subcellular Fractions; Sulfonamides; Synapses | 2009 |
Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Calcification, Physiologic; Calcium; Cell Differentiation; Chlorocebus aethiops; Chondrocytes; Chondrogenesis; Core Binding Factor Alpha 1 Subunit; COS Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Glycine; Humans; Membrane Glycoproteins; Metatarsal Bones; Mice; Mice, Knockout; N-Methylaspartate; Osteopontin; Racemases and Epimerases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine; Time Factors; Tissue Culture Techniques; Transfection | 2009 |
Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C.
Topics: 14-3-3 Proteins; Alanine; Animals; Biotinylation; Cell Line, Transformed; Cells, Cultured; Cerebellum; Dendrites; Excitatory Amino Acid Antagonists; Gene Expression; Green Fluorescent Proteins; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Insulin-Like Growth Factor I; Luminescent Proteins; Mice; Mutation; N-Methylaspartate; Neurons; Oncogene Protein v-akt; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Transfection; Valine | 2009 |
Neuron-astrocyte interactions in the medial nucleus of the trapezoid body.
Topics: Amino Acid Transport System X-AG; Animals; Anthozoa; Astrocytes; Brain Stem; Calcium; Cell Communication; Chelating Agents; Electric Stimulation; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Synapses; Synaptic Transmission; Time Factors | 2010 |
N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
Topics: Animals; Arachidonic Acids; Glycine; Inhibitory Postsynaptic Potentials; Miniature Postsynaptic Potentials; N-Methylaspartate; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sarcosine; Serine; Spinal Cord; Synaptic Transmission | 2010 |
Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Female; Gene Deletion; Hippocampus; Humans; Male; Mice; Mice, Knockout; N-Methylaspartate; Phosphoglycerate Dehydrogenase; Phosphorylation; Schizophrenia; Serine | 2010 |
Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits.
Topics: Adrenergic beta-Agonists; Animals; Biophysical Phenomena; Electric Stimulation; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Isoproterenol; Long-Term Potentiation; Mice; Mitogen-Activated Protein Kinase 1; Mutation; N-Methylaspartate; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Pyramidal Cells; Receptors, Adrenergic, beta; Receptors, N-Methyl-D-Aspartate; Serine | 2011 |
Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; CA1 Region, Hippocampal; Dendritic Spines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Long-Term Synaptic Depression; Mice; Mice, Transgenic; Microscopy, Confocal; N-Methylaspartate; Neurons; Organ Culture Techniques; Receptors, Glutamate; Serine; Symporters; Synapses | 2011 |
Coactivation of NMDA receptors by glutamate and D-serine induces dilation of isolated middle cerebral arteries.
Topics: Animals; Blotting, Western; Cells, Cultured; Denervation; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Cells; Endothelium, Vascular; Fluorescent Antibody Technique; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Middle Cerebral Artery; Myography; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Serine; Stereoisomerism; Vasodilation | 2012 |
Timing-dependent reduction in ethanol sedation and drinking preference by NMDA receptor co-agonist d-serine.
Topics: Alcohol Drinking; Alcoholic Intoxication; Analysis of Variance; Animals; Ethanol; Glutamic Acid; Glycine; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Time Factors | 2012 |
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide-cGMP and PI3K/mTOR pathways.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Freezing Reaction, Cataleptic; Guanosine; Hindlimb Suspension; Immunosuppressive Agents; Male; Mice; N-Methylaspartate; Nitric Oxide; Phosphatidylinositol 3-Kinases; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sirolimus; Swimming; TOR Serine-Threonine Kinases | 2012 |
Involvement of NMDA receptors in the antidepressant-like action of adenosine.
Topics: Adenosine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Chlorides; Depression; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Imipramine; Immobilization; Ketamine; Male; Mice; N-Methylaspartate; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Serine; Swimming; Time Factors; Zinc Compounds | 2012 |
Activity-dependent modulation of the interaction between CaMKIIα and Abi1 and its involvement in spine maturation.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Calcium Ionophores; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Catalytic Domain; Cells, Cultured; Cerebral Cortex; Dendritic Spines; Embryo, Mammalian; Excitatory Amino Acid Agents; Glucose Transporter Type 1; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Immunoprecipitation; Iodine Isotopes; Ionomycin; N-Methylaspartate; Neurons; Phosphorylation; Protein Binding; Qa-SNARE Proteins; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Serine; SNARE Proteins; Synapses; Transfection; Vesicular Glutamate Transport Protein 1 | 2012 |
AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors.
Topics: A Kinase Anchor Proteins; Action Potentials; Analysis of Variance; Animals; Biophysics; Calcineurin; Calcium; Cells, Cultured; Dendritic Spines; Disks Large Homolog 4 Protein; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Guanylate Kinases; Hippocampus; Immunoprecipitation; In Vitro Techniques; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Phosphorylation; Quinoxalines; Receptors, AMPA; Serine; Silver Staining; Sodium Channel Blockers; Subcellular Fractions; Synapses; Tetrodotoxin | 2012 |
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Excitatory Postsynaptic Potentials; Glutamic Acid; Ligation; Male; N-Methylaspartate; Neuralgia; Posterior Horn Cells; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Nerves; Synapses | 2013 |
Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.
Topics: Amacrine Cells; Animals; Axons; Binding Sites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fish Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Goldfish; Inhibitory Postsynaptic Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2013 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ligands; Male; Maze Learning; Mice; N-Methylaspartate; Quinolones; Receptors, N-Methyl-D-Aspartate; Serine | 2013 |
D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2014 |
Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Space; Glutamic Acid; Glycine; Hippocampus; Mice, Knockout; Microdialysis; N-Methylaspartate; Neurons; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Serine; Taurine | 2015 |
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Nerve Tissue Proteins; Neuralgia; Phosphorylation; Physical Stimulation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Spinal Cord | 2017 |
L-Serine dietary supplementation is associated with clinical improvement of loss-of-function
Topics: Animals; Brain Diseases; Child; Cognition; Dietary Supplements; Humans; Loss of Function Mutation; Male; Mice; Models, Molecular; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Rett Syndrome; Serine | 2019 |
Regulation of the SIRT1 signaling pathway in NMDA-induced Excitotoxicity.
Topics: Calcium; Calcium Signaling; Cell Death; Cell Line, Tumor; Down-Regulation; ELAV-Like Protein 1; Excitatory Amino Acid Agonists; Humans; N-Methylaspartate; Neurons; Neurotoxicity Syndromes; Phosphorylation; Protein Kinase C; RNA Stability; RNA, Messenger; Serine; Sirtuin 1 | 2020 |
PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Disks Large Homolog 4 Protein; Down-Regulation; Hippocampus; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Phosphorylation; Post-Synaptic Density; Primary Cell Culture; Rats; Serine; Synaptic Potentials | 2020 |
Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity.
Topics: Animals; Blood Glucose; Disease Models, Animal; Female; Glucose; Glucose Intolerance; Homeostasis; Insulin Secretion; Insulin-Secreting Cells; Male; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Phenotype; Receptors, N-Methyl-D-Aspartate; Serine; Sex Characteristics | 2021 |
Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform.
Topics: D-Amino-Acid Oxidase; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Structure-Activity Relationship | 2022 |
Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.
Topics: Animals; Astrocytes; Drosophila; Glutamic Acid; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Thirst; Water | 2022 |
Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients.
Topics: Alzheimer Disease; Amino Acids; Amyotrophic Lateral Sclerosis; Homeostasis; Humans; N-Methylaspartate; Parkinson Disease; Putamen; Receptors, N-Methyl-D-Aspartate; Serine | 2023 |