serine has been researched along with methotrexate in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (51.28) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 5 (12.82) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Karasek, M; Liu, SC | 2 |
| Muñoz, M; Perán, S; Saiz, MT | 1 |
| Booth, CL; Howell, EE; Kraut, J; Villafranca, JE; Warren, MS | 1 |
| Cashmore, AR; Dreyer, RN; Kashani-Sabet, M; Moroson, BA; Pallai, M; Saketos, M; Scanlon, KJ | 1 |
| Altz-Smith, M; Baggott, JE; Morgan, SL | 1 |
| Harrap, KR; Jackson, RC | 1 |
| Albrecht, AM; Hutchison, DJ; Pearce, FK | 1 |
| Chu, MY; Hoovis, ML | 1 |
| Bertino, JR; Hillcoat, BL | 1 |
| Hutchison, DJ; Rader, JI | 1 |
| Ellegaard, J; Esmann, V; Henriksen, L | 1 |
| Bertino, JR; McCullough, JL; O'Brien, P | 1 |
| Lin, MS; Winchell, HS | 1 |
| Aunio, R; Hakala, MT | 1 |
| Belousova, AK; Gerasimova, GK; Greshilov, MM; Vorontsov, IN | 2 |
| Lejeune, J | 1 |
| Banerjee, D; Bertino, JR; Flasshove, M; Moore, MA | 1 |
| Banerjee, D; Bertino, JR; Li, MX; Mineishi, S; Schweitzer, BI; Volkenandt, M; Waltham, M; Zhao, SC | 1 |
| Adams, J; Evenson, DA; McIvor, RS; Wagner, CR | 1 |
| Abrams, GD; Chatson, KB; King, J; Prabhu, V | 1 |
| Gao, F; Goldman, ID; Zhao, R | 1 |
| Grosse-Wilde, H; Jacob, JR; Kreuzfelder, E; Maschke, J; Menne, S; Roggendorf, M; Tennant, BC | 1 |
| HUTCHISON, DJ; JOHNSON, AH | 1 |
| MORSE, PA; POTTER, VR | 1 |
| Abali, EE; Banerjee, D; Bertino, JR; Menon, LG; Mishra, PJ; Peters, R; Skacel, N | 1 |
| Barnes, NC; Bradford, TM; Cambier, JC; Hogarth, PM; Musgrave, IF; Powell, MS; Wines, BD | 1 |
| Chang, WN; Chen, BH; Fu, TF; Huang, HS; Tsai, JN | 1 |
| De Brouwer, V; Gambonnet, B; Lambert, WE; Loizeau, K; Ravanel, S; Rébeillé, F; Renou, JP; Van Der Straeten, D; Yu, A | 1 |
| Bertino, JR; Tedeschi, PM; Vazquez, A | 1 |
| Bertino, JR; Boros, LG; Chan, LL; DiPaola, RS; Dolfi, SC; Dvorzhinski, D; Gounder, M; Hirshfield, KM; Lin, H; Markert, EK; Oltvai, ZN; Qiu, J; Tedeschi, PM; Vazquez, A | 1 |
| Calise, SJ; Chan, EK; Krueger, C; Nguyen, T; Purich, DL; Saleem, DA; Yin, JD | 1 |
| Raichaudhuri, A | 1 |
| Athineos, D; Blyth, K; Burgos-Barragan, G; Dhayade, S; Dornier, E; Mackay, GM; Meiser, J; Morton, JP; Niclou, SP; Oizel, K; Patel, KJ; Pietzke, M; Schuster, A; Sumpton, D; Vande Voorde, J; Vazquez, A; Wit, N | 1 |
| Bolok, Y; Brunengraber, H; Hoppe, G; McCollum, L; Sears, JE; Sharma, A; Singh, C; Song, W; Tran, V | 1 |
| Elledge, SJ; Fang, Y; Gentili, M; Gewurz, BE; Guo, R; Hung, DT; Kim, SH; Leary, CNO; Liang, JH; Mootha, VK; Shah, H; Zhang, S; Zhang, Y | 1 |
| Hosokawa, S; Itoh, T; Narawa, T; Narita, Y | 1 |
2 review(s) available for serine and methotrexate
| Article | Year |
|---|---|
Folate status of patients on low-dose methotrexate therapy.
Topics: Folic Acid; Humans; Lymphocytes; Methotrexate; Serine | 1989 |
Regulation of dihydrofolate reductase and other folate-requiring enzymes.
Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Guinea Pigs; Homocysteine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia; Leukocytes; Ligases; Methotrexate; Oxidoreductases; Rats; Salmonella typhimurium; Serine; Streptococcus; Tetrahydrofolate Dehydrogenase | 1968 |
37 other study(ies) available for serine and methotrexate
| Article | Year |
|---|---|
Isolation and serial cultivation of rabbit skin epithelial cells.
Topics: Animals; Cell Division; Cells, Cultured; Collagen; Culture Media; Cytological Techniques; Edetic Acid; Egtazic Acid; Epithelial Cells; Epithelium; Female; Male; Methotrexate; Phosphates; Rabbits; Serine; Skin; Thymidine; Trypsin | 1978 |
Isolation and growth of adult human epidermal keratinocytes in cell culture.
Topics: Adult; Cell Division; Cells, Cultured; Collagen; Dexamethasone; Humans; Keratins; Methotrexate; Serine; Skin | 1978 |
Rapid and steady-state amino acid transport in perfused human fibroblasts and colon adenocarcinoma cells: effects of methotrexate.
Topics: Adenocarcinoma; Amino Acids; Biological Transport; Colonic Neoplasms; Fibroblasts; Humans; Methotrexate; Phenylalanine; Serine; Tumor Cells, Cultured | 1990 |
Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli; Genes; Genes, Bacterial; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Mathematics; Methotrexate; Mutation; Protein Binding; Protons; Serine; Tetrahydrofolate Dehydrogenase | 1987 |
Inhibition of methionine uptake by methotrexate in mouse leukemia L1210 cells.
Topics: Animals; Biological Transport, Active; Cell Line; Depression, Chemical; Leukemia L1210; Methionine; Methotrexate; Mice; Serine | 1987 |
Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.
Topics: Adult; Arthritis, Rheumatoid; Diet; Erythrocytes; Female; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Serine; Vitamins | 1987 |
Studies with a mathematical model of folate metabolism.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Folic Acid; Formates; Glycine; Hydrolases; Kinetics; Leukemia L1210; Mathematics; Methotrexate; Models, Biological; Oxidoreductases; Pentosephosphates; Purines; Serine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Transferases | 1973 |
Methylenetetrahydrofolate dehydrogenase of the amethopterin-resistant strain Streptococcus faecium var. durans A and its repressibility by serine.
Topics: Aminohydrolases; Culture Media; Enzyme Repression; Kinetics; Ligases; Methotrexate; NADP; Protein Hydrolysates; Serine; Spectrophotometry; Streptococcus; Tetrahydrofolate Dehydrogenase; Transferases | 1968 |
Enhancement of the antiproliferative action of 1- -D-arabinofuranosylcytosine by methotrexate in murine leukemic cells (L5178Y).
Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Cytarabine; Drug Synergism; Furans; Hypoxanthines; Leukemia, Experimental; Methotrexate; Mice; Mitosis; Phosphates; Serine; Time Factors; Tritium | 1973 |
Selection and characterization of mutant strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin.
Topics: Culture Media; Depression, Chemical; Drug Antagonism; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Genetics, Microbial; Methotrexate; Mutation; Purines; Quinazolines; Serine; Streptococcus; Tetrahydrofolates; Thymine Nucleotides | 1972 |
Deficient folate activity during treatment of psoriasis with methotrexate diagnosed by determination of serine synthesis in lymphocytes.
Topics: Adult; Aged; Carbon Isotopes; Female; Folic Acid Deficiency; Formates; Humans; In Vitro Techniques; Intestinal Absorption; Lymphocytes; Male; Methotrexate; Middle Aged; Psoriasis; RNA; Serine; Vitamin B 12 | 1972 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Kinetics of amino acid transport across bone marrow cell membranes.
Topics: Amino Acids; Animals; Biological Transport, Active; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Membrane; DNA; Dogs; Extracellular Space; Glucagon; Glutamates; Histidine; Imidazoles; Insulin; Kinetics; Methionine; Methotrexate; Models, Biological; Serine; Time Factors; Tryptophan | 1970 |
Tetrahydrofolate-dependent enzymes in sarcoma 180 cells sensitive and resistant to amethopterin.
Topics: Aminohydrolases; Animals; Culture Techniques; Folic Acid; Formates; Ligases; Methotrexate; Mice; Oxidoreductases; Sarcoma 180; Serine; Transferases; Ultracentrifugation | 1968 |
[Evaluation of biochemical criteria for sensitivity of tumor cells to methotrexate by means of mathematic simulation].
Topics: Animals; Carcinoma, Ehrlich Tumor; Folic Acid; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Models, Biological; Purines; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
[Fragile site Xq27 and metabolism of monocarbons].
Topics: Amino Acids; Aminolevulinic Acid; Female; Formyltetrahydrofolates; Humans; Hydroxyproline; Intellectual Disability; Lymphocytes; Methotrexate; Serine; Sex Chromosomes; X Chromosome | 1980 |
[Mathematical description and study of the folic acid cycle reactions].
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Folic Acid; Humans; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Mice; Purines; Rats; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
Increased resistance to methotrexate in human hematopoietic cells after gene transfer of the Ser31 DHFR mutant.
Topics: Antigens, CD34; Colony-Forming Units Assay; Drug Resistance; Fetal Blood; Genetic Therapy; Hematopoietic Stem Cells; Humans; Infant, Newborn; Interleukin-1; Interleukin-3; Kinetics; Methotrexate; Recombinant Proteins; Retroviridae; Serine; Tetrahydrofolate Dehydrogenase; Time Factors; Transfection | 1995 |
Transfection with a cDNA encoding a Ser31 or Ser34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance.
Topics: Animals; Arginine; Base Sequence; Blotting, Northern; Blotting, Southern; Bone Marrow; CHO Cells; Colony-Forming Units Assay; Cricetinae; DNA, Complementary; Drug Resistance; Gene Amplification; Gene Transfer Techniques; Genetic Markers; Humans; Methotrexate; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenotype; Plasmids; Retroviridae; Serine; Stem Cells; Tetrahydrofolate Dehydrogenase; Transfection | 1994 |
Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan.
Topics: Animals; Crystallography, X-Ray; Folic Acid Antagonists; Kinetics; Methotrexate; Mice; Mutagenesis, Site-Directed; Phenylalanine; Serine; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 1996 |
13C nuclear magnetic resonance detection of interactions of serine hydroxymethyltransferase with C1-tetrahydrofolate synthase and glycine decarboxylase complex activities in Arabidopsis.
Topics: Amino Acid Oxidoreductases; Aminohydrolases; Arabidopsis; Binding Sites; Carbon Isotopes; Formate-Tetrahydrofolate Ligase; Glycine; Glycine Decarboxylase Complex; Glycine Dehydrogenase (Decarboxylating); Glycine Hydroxymethyltransferase; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Multienzyme Complexes; Serine; Sulfanilamide; Sulfanilamides | 1996 |
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
Topics: Amino Acid Substitution; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Chlorides; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Drug Resistance, Neoplasm; Kinetics; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Phenotype; Phenylalanine; Reduced Folate Carrier Protein; Serine; Transfection; Tumor Cells, Cultured | 1999 |
Thymidine utilization abnormality in proliferating lymphocytes and hepatocytes of the woodchuck.
Topics: 3T3 Cells; Adenine; Animals; Blotting, Northern; Blotting, Southern; Cell Division; Humans; Liver; Lymphocytes; Marmota; Methotrexate; Mice; Models, Biological; Serine; Thymidine; Thymidine Kinase; Thymidine Monophosphate | 2001 |
FOLIC ACID METABOLISM IN ANTIFOLIC-RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS.
Topics: Adenine; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Guanine; Metabolism; Methotrexate; Mutation; Purines; Research; Serine; Thymine; Xanthines | 1964 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
Topics: Amino Acids; Animals; Binding Sites; Blotting, Western; Catalysis; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; DNA Primers; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutathione Transferase; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Kinetics; Leucine; Methotrexate; Microscopy, Fluorescence; Models, Biological; Mutagenesis, Site-Directed; Mutation; NADP; Protein Biosynthesis; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2005 |
Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding.
Topics: Animals; Antigens, CD; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Dimerization; Down-Regulation; Humans; Immunoglobulin G; Ligands; Methotrexate; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Proline; Receptors, IgG; Serine; Signal Transduction; Tetrahydrofolate Dehydrogenase | 2006 |
Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression Profiling; Glycine Hydroxymethyltransferase; Green Fluorescent Proteins; Humans; Isoenzymes; Leucovorin; Methotrexate; Microscopy, Confocal; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine; Tetrahydrofolates; Zebrafish; Zebrafish Proteins | 2007 |
A genome-wide and metabolic analysis determined the adaptive response of Arabidopsis cells to folate depletion induced by methotrexate.
Topics: Adaptation, Biological; Arabidopsis; Carbon; Cell Division; Energy Metabolism; Folic Acid; Gene Expression; Gene Expression Profiling; Genome, Plant; Homeostasis; Leucovorin; Methotrexate; Nucleotides; Plastids; Serine; Sulfates; Xenobiotics | 2008 |
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondria; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serine; Transcriptome | 2013 |
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Cell Line, Tumor; Embryonic Stem Cells; Energy Metabolism; Fatty Acids; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Glycine; Humans; Male; Metabolic Flux Analysis; Metabolic Networks and Pathways; Methotrexate; Mice; Multienzyme Complexes; NADP; Neoplasms; Protein Biosynthesis; Purines; Serine; Transferases | 2013 |
'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.
Topics: Aminopterin; Carbon; Culture Media; Gene Knockdown Techniques; Glycine; Glycine Hydroxymethyltransferase; Guanosine; HeLa Cells; Humans; Hypoxanthine; IMP Dehydrogenase; Metabolic Networks and Pathways; Methotrexate; RNA, Small Interfering; Serine; Tetrahydrofolate Dehydrogenase | 2016 |
Arabidopsis thaliana MRP1 (AtABCC1) nucleotide binding domain contributes to arsenic stress tolerance with serine triad phosphorylation.
Topics: Arabidopsis; Arabidopsis Proteins; Arsenic; Arsenites; ATP-Binding Cassette Transporters; Binding Sites; Casein Kinase II; Folic Acid Antagonists; Methotrexate; Phosphorylation; Protein Domains; Serine; Stress, Physiological; Vacuoles | 2016 |
Increased formate overflow is a hallmark of oxidative cancer.
Topics: Adenoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Female; Formates; Gene Expression Regulation, Neoplastic; Glycine Hydroxymethyltransferase; Intestinal Mucosa; Intestinal Neoplasms; Intestines; Isoenzymes; Male; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Methotrexate; Mice; Mice, Inbred C57BL; Mitochondria; Oxidation-Reduction; Serine; Tumor Microenvironment | 2018 |
Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity.
Topics: Animals; Carbon; Disease Models, Animal; Glycine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoquinolines; Liver; Metabolic Networks and Pathways; Methotrexate; Mice; Mice, Knockout; Oxygen; Protein Stability; Retina; Retinopathy of Prematurity; Serine; Tissue Culture Techniques; Up-Regulation | 2019 |
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication.
Topics: A549 Cells; Animals; Carbon; Chlorocebus aethiops; COVID-19; Cytopathogenic Effect, Viral; Folic Acid; Folic Acid Antagonists; Glucose; Humans; Methotrexate; RNA, Viral; SARS-CoV-2; Serine; Transcription, Genetic; Vero Cells; Viral Proteins; Virus Replication | 2021 |
Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport.
Topics: Folic Acid; HeLa Cells; Humans; Methotrexate; Proton-Coupled Folate Transporter; Serine | 2021 |