serine and levoleucovorin

serine has been researched along with levoleucovorin in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199010 (45.45)18.7374
1990's2 (9.09)18.2507
2000's6 (27.27)29.6817
2010's3 (13.64)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Altz-Smith, M; Baggott, JE; Morgan, SL1
Heinemann, M; Sloane, NH1
Konno, T; Narisawa, K; Tada, K; Yokoyama, Y; Yoshida, T1
Bertino, JR; McCullough, JL; O'Brien, P1
Appling, DR; Kastanos, E; Pasternack, LB; Woldman, YY1
Gao, F; Goldman, ID; Zhao, R1
Jones, GM; Narkewicz, MR; Thompson, HR1
Gupta, A; Jala, VR; Rao, GS; Rao, NA; Saravanan, P; Savithri, HS; Subramanya, HS; Trivedi, V1
LASCELLES, J; WOODS, DD1
AWAPARA, J; DOCTOR, VM1
MATSUYA, Y; YAMANE, I1
O'BARR, TP1
MARCHETTI, M; MORUZZI, G; VIVIANI, R1
CROSS, MJ; LASCELLES, J; WOODS, DD1
Breazeale, SD; Naismith, JH; Raetz, CR; Williams, GJ1
Collakova, E; Díaz de la Garza, R; Goyer, A; Gregory, JF; Hanson, AD; Quinlivan, EP; Shachar-Hill, Y; Williamson, J1
Chang, WN; Chen, BH; Fu, TF; Huang, HS; Tsai, JN1
De Brouwer, V; Gambonnet, B; Lambert, WE; Loizeau, K; Ravanel, S; Rébeillé, F; Renou, JP; Van Der Straeten, D; Yu, A1
Fan, J; Kamphorst, JJ; Rabinowitz, JD; Shlomi, T; Thompson, CB; Ye, J1
Baggott, JE; Tamura, T1
Chen, L; Ducker, GS; Esposito, M; Ghergurovich, JM; Kang, Y; Morscher, RJ; Rabinowitz, JD; Teng, X1
Dekhne, AS; Frühauf, J; Gangjee, A; Hou, Z; Hüttemann, M; Kalpage, H; Kim, S; Matherly, LH; Nayeen, MJ; Ning, C; O'Connor, C; Shah, K; Wallace-Povirk, A1

Reviews

1 review(s) available for serine and levoleucovorin

ArticleYear
Folate-Dependent Purine Nucleotide Biosynthesis in Humans.
    Advances in nutrition (Bethesda, Md.), 2015, Volume: 6, Issue:5

    Topics: Carbon; Circadian Rhythm; Folic Acid; Formates; Glycine; Humans; Leucovorin; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Purine Nucleotides; Serine; Uric Acid

2015

Other Studies

21 other study(ies) available for serine and levoleucovorin

ArticleYear
Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.
    Arthritis and rheumatism, 1987, Volume: 30, Issue:12

    Topics: Adult; Arthritis, Rheumatoid; Diet; Erythrocytes; Female; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Serine; Vitamins

1987
Hydroxymethylation of the benzene ring. V. NADPH requirement for aryl hydroxymethylation by a C-1 donor bound to a macromolecule.
    Biochimica et biophysica acta, 1970, Feb-24, Volume: 201, Issue:2

    Topics: Animals; Ascorbic Acid; Benzene; Cell-Free System; Folic Acid; Guinea Pigs; Leucovorin; Microsomes, Liver; NADP; Phenols; Resins, Plant; Serine; Tritium; Vibration

1970
Hyperglycinemia: a defect in glycine cleavage reaction.
    The Tohoku journal of experimental medicine, 1969, Volume: 98, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Autoanalysis; Carbohydrates; Carbon Dioxide; Carbon Isotopes; Chromatography, Thin Layer; Female; Glycine; Humans; In Vitro Techniques; Infant; Injections, Intravenous; L-Serine Dehydratase; Leucovorin; Liver; Serine; Time Factors; Transferases

1969
Inhibition of growth of leukemia cells by enzymic folate depletion.
    Science (New York, N.Y.), 1971, Apr-09, Volume: 172, Issue:3979

    Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine

1971
Use of 13C nuclear magnetic resonance to evaluate metabolic flux through folate one-carbon pools in Saccharomyces cerevisiae.
    Methods in enzymology, 1997, Volume: 281

    Topics: Carbon Isotopes; Choline; Folic Acid; Formates; Glycine; Leucovorin; Magnetic Resonance Spectroscopy; Purines; Saccharomyces cerevisiae; Serine

1997
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
    Biochemical pharmacology, 1999, Nov-15, Volume: 58, Issue:10

    Topics: Amino Acid Substitution; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Chlorides; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Drug Resistance, Neoplasm; Kinetics; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Phenotype; Phenylalanine; Reduced Folate Carrier Protein; Serine; Transfection; Tumor Cells, Cultured

1999
Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Amino Acid Oxidoreductases; Animals; Animals, Newborn; Brain; Carrier Proteins; Embryonic and Fetal Development; Female; Folic Acid; Glycine Hydroxymethyltransferase; Kidney; Leucovorin; Liver; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Oxidoreductases Acting on CH-NH Group Donors; Placenta; Pregnancy; Rabbits; Serine; Tetrahydrofolates; Transferases

2001
Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
    The Journal of biological chemistry, 2002, May-10, Volume: 277, Issue:19

    Topics: Aldehydes; Animals; Catalysis; Catalytic Domain; Crystallography, X-Ray; Dimerization; Escherichia coli; Geobacillus stearothermophilus; Glycine; Glycine Hydroxymethyltransferase; Histidine; Leucovorin; Mice; Models, Chemical; Models, Molecular; Protein Binding; Protein Conformation; Protein Structure, Secondary; Serine

2002
The synthesis of serine and Leuconostoc citrovorum factor by cell suspensions of Streptococcus faecalis R.
    The Biochemical journal, 1954, Volume: 58, Issue:3

    Topics: Antimetabolites; Enterococcus faecalis; Folic Acid; Leuconostoc; Leucovorin; Serine; Streptococcus; Suspensions

1954
The incorporation of serine-3-C14 into citrovorum factor.
    The Journal of biological chemistry, 1956, Volume: 220, Issue:1

    Topics: Antimetabolites; Folic Acid; Leucovorin; Serine

1956
CULTURE OF SINGLE MAMMALIAN CELLS.
    Nature, 1963, Jul-20, Volume: 199

    Topics: Animals; Cattle; Cholesterol; Corrinoids; Culture Media; Insulin; Leucovorin; Research; Research Design; Serine; Thymidine; Tissue Culture Techniques; Vitamin B 12

1963
EFFECT OF ALANINE AND THREONINE ON THE SYNTHESIS OF SERINE BY LEUCONOSTOC MESENTEROIDES.
    Journal of bacteriology, 1963, Volume: 86

    Topics: Alanine; Amino Acids; Bacterial Proteins; Benzoates; Formates; Glutamine; Glycine; Histidine; Leuconostoc; Leucovorin; Proteins; Research; Serine; Threonine

1963
OROTIC ACID AND METABOLISM OF ONE CARBON UNIT: CONVERSION OF FOLIC ACID TO CITROVORUM FACTOR AND METHIONINE SYNTHESIS IN CHICK LIVER.
    Archives italiennes de biologie, 1963, Oct-05, Volume: 101

    Topics: Animals; Carbon; Chickens; Folic Acid; Homocysteine; Leuconostoc; Leucovorin; Liver; Metabolism; Methionine; Orotic Acid; Poultry; Proteins; Research; Serine; Vitamin B 12; Vitamin B 12 Deficiency

1963
Leuconostoc citrovorum factor and the synthesis of serine by micro-organisms.
    The Biochemical journal, 1951, Volume: 49, Issue:5

    Topics: Antimetabolites; Bacteria; Folic Acid; Leuconostoc; Leucovorin; Serine

1951
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
    The Journal of biological chemistry, 2005, Jun-17, Volume: 280, Issue:24

    Topics: Amino Acid Sequence; Amino Sugars; Antimicrobial Cationic Peptides; Binding Sites; Carboxy-Lyases; Chromatography, Gel; Crystallography, X-Ray; Escherichia coli; Glutamic Acid; Kinetics; Leucovorin; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; Oxygen; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Selenomethionine; Sequence Homology, Amino Acid; Serine; Uridine Diphosphate; Uridine Diphosphate Glucuronic Acid

2005
5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves.
    The Journal of biological chemistry, 2005, Jul-15, Volume: 280, Issue:28

    Topics: Arabidopsis; Carbon Dioxide; Carbon-Nitrogen Ligases; Catalysis; DNA, Bacterial; Flowers; Formate-Tetrahydrofolate Ligase; Formyltetrahydrofolates; Glycine; Glycine Hydroxymethyltransferase; Hydrolysis; Leucovorin; Mitochondria; Models, Biological; Models, Chemical; Models, Genetic; Mutagenesis, Site-Directed; Mutation; Phenotype; Photosynthesis; Plant Leaves; Protein Isoforms; RNA; Serine; Temperature; Tetrahydrofolates; Time Factors

2005
Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11

    Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression Profiling; Glycine Hydroxymethyltransferase; Green Fluorescent Proteins; Humans; Isoenzymes; Leucovorin; Methotrexate; Microscopy, Confocal; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Serine; Tetrahydrofolates; Zebrafish; Zebrafish Proteins

2007
A genome-wide and metabolic analysis determined the adaptive response of Arabidopsis cells to folate depletion induced by methotrexate.
    Plant physiology, 2008, Volume: 148, Issue:4

    Topics: Adaptation, Biological; Arabidopsis; Carbon; Cell Division; Energy Metabolism; Folic Acid; Gene Expression; Gene Expression Profiling; Genome, Plant; Homeostasis; Leucovorin; Methotrexate; Nucleotides; Plastids; Serine; Sulfates; Xenobiotics

2008
Quantitative flux analysis reveals folate-dependent NADPH production.
    Nature, 2014, Jun-12, Volume: 510, Issue:7504

    Topics: Animals; Carbon; Cell Line; Cell Line, Tumor; Cytosol; Folic Acid; Glutathione; Glycine; HEK293 Cells; Humans; Isoenzymes; Leucovorin; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mitochondria; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Serine; Tetrahydrofolates

2014
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
    Cell metabolism, 2016, 06-14, Volume: 23, Issue:6

    Topics: Aminoimidazole Carboxamide; Carbon; Cell Compartmentation; Cell Proliferation; Colonic Neoplasms; CRISPR-Cas Systems; Cytosol; Folic Acid; Formates; Gene Knockout Techniques; Gene Library; Glycine; Glycine Hydroxymethyltransferase; HCT116 Cells; HEK293 Cells; Humans; Leucovorin; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Mutation; NADP; Ribonucleotides; Serine; Xenograft Model Antitumor Assays

2016
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-
    Molecular pharmacology, 2020, Volume: 97, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Membrane; Cytosol; Drug Screening Assays, Antitumor; Gene Knockout Techniques; Glutathione; Glycine Hydroxymethyltransferase; Humans; Leucovorin; Mitochondria; Pancreatic Neoplasms; Purine Nucleotides; Pyrimidines; Pyrroles; Reactive Oxygen Species; Serine; Tetrahydrofolates

2020